33:
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Buchdunger, E.; Cioffi, C. L.; Law, N.; Stover, D.; Ohno-Jones, S.; Druker, B. J.; Lydon, N. B. (2000). "Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors".
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Druker, B. J.; Tamura, S.; Buchdunger, E.; Ohno, S.; Segal, G. M.; Fanning, S.; Zimmermann, J.; Lydon, N. B. (1996). "Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells".
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that is the molecular cause of a specific cancer, the defective cancer cells can be killed without any major side effects on normal cells. The remarkable efficacy of
Gleevec profoundly changed the perception of
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505:
Druker, B. J.; Talpaz, M.; Resta, D. J.; Peng, B.; Buchdunger, E.; Ford, J. M.; Lydon, N. B.; Kantarjian, H.; Capdeville, R.; Ohno-Jones, S.; Sawyers, C. L. (2001).
1727:
318:
397:. The international prizes that Nick Lydon has received include, most recently, the Lasker-DeBakey Clinical Medical Research Award from The Lasker Foundation.
1737:
1732:
393:" in 1994, they have become the pharmaceutical industry's most popular class of drug target today, accounting for over 50% of cancer drug discovery
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in 2000, with whom he worked until 2002. Thereafter, he established several companies that continue to develop drugs to treat various conditions.
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507:"Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia"
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by changing rapidly fatal diseases into easily treatable conditions, and showed that, by targeting an
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212:(born 27 February 1957) is a British scientist and entrepreneur. In 2009, he was awarded the
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as Chargé de Récherche. Three years later, he moved to
Switzerland to work with
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224:, also known as Imatinib, a selective BCR-ABL inhibitor for the treatment of
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Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum
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Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum
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228:(CML), which converted a fatal cancer into a manageable chronic condition.
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442:"Lasker – DeBakey Clinical Medical Research Award: Award Description"
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Recipients of the Lasker–DeBakey
Clinical Medical Research Award
368:, a drug that has saved the lives of thousands of patients with
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as therapeutic targets. From being considered to be virtually "
608:
The
Journal of Pharmacology and Experimental Therapeutics
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Nick Lydon played a decisive role in the development of
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in 1978 and received his PhD in biochemistry from the
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314:, General Motors Cancer Research Foundation, 2002.
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350:Royal Society GlaxoSmithKline Prize and Lecture
319:Lasker-DeBakey Clinical Medical Research Award
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758:
376:. Gleevec revolutionised the field of cancer
8:
645:. University of Dundee. 2011. Archived from
248:. He earned a Bachelor of Science degree in
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272:In 1982, Lydon accepted a position with
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374:gastrointestinal stromal tumours (GIST)
1728:People educated at Strathallan School
7:
370:chronic myelogenous leukaemia (CML)
1738:Alumni of the University of Dundee
14:
1733:Alumni of the University of Leeds
305:AACR-Bruce F. Cain Memorial Award
1192:/ John Frederick Grassle (2013)
511:New England Journal of Medicine
480:"Laureates of the Japan Prize"
298:Warren Alpert Foundation Prize
1:
902:Ernest John Christopher Polge
1758:Fellows of the Royal Society
1697:Prince Andrew, Duke of York
524:10.1056/NEJM200104053441401
356:Lydon's nomination for the
344:Fellow of the Royal Society
1779:
1748:British cancer researchers
484:The Japan Prize Foundation
282:Ciba-Geigy Pharmaceuticals
918:William Hayward Pickering
793:Ephraim Katchalski-Katzir
226:chronic myeloid leukaemia
182:
131:
30:
1753:British company founders
1574:Maria Grazia Spillantini
1554:Christopher J. Schofield
548:publications indexed by
336:, with Brian Druker and
1059:/ Keith J. Sainsbury /
725:"GlaxoSmithKline prize"
684:(subscription required)
220:for the development of
1230:Emmanuelle Charpentier
849:Frank Sherwood Rowland
399:
236:Lydon was educated at
1534:William D. Richardson
420:www.scienceheroes.com
214:Lasker Clinical Award
110:Lasker Clinical Award
1335:John Michael Wallace
679:University of Dundee
303:Twenty First Annual
264:, Scotland in 1982.
262:University of Dundee
71:University of Dundee
1743:British biochemists
1646:Margaret Buckingham
1584:Brigitta Stockinger
1319:/ Kazuo Hagimoto /
1158:Tadamitsu Kishimoto
888:Jacques-Louis Lions
699:"Dr Nicholas Lydon"
643:"Dr Nicholas Lydon"
254:University of Leeds
95:BluePrint Medicines
65:University of Leeds
1297:Robert A. Weinberg
1279:Robert G. Gallager
1224:Steven D. Tanksley
1210:Theodore Friedmann
1113:Victor A. McKusick
1071:Masatoshi Takeichi
1019:Timothy R. Parsons
1015:John B. Goodenough
1009:Kimishige Ishizaka
984:Jack L. Strominger
980:W. Wesley Peterson
960:Hiroyuki Yoshikawa
956:Joseph Engelberger
932:Edward F. Knipling
669:Lydon, Nicholas B.
576:10.1038/nm0596-561
550:Microsoft Academic
366:Gleevec (Imatinib)
292:Honours and awards
238:Strathallan School
16:British biochemist
1705:
1704:
1594:Jean-Paul Vincent
1484:Gillian Griffiths
1348:
1347:
1317:Masataka Nakazawa
1311:Christopher Field
1196:Yasuharu Suematsu
1140:Shun-ichi Iwasaki
1099:Peter Shaw Ashton
1039:Benoit Mandelbrot
1033:Andrzej Tarkowski
853:Elias James Corey
517:(14): 1031–1037.
446:Lasker Foundation
207:Nicholas B. Lydon
204:
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133:Scientific career
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1681:Eli Yablonovitch
1504:Gideon Henderson
1375:
1368:
1361:
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1186:C. Grant Willson
974:Marc Van Montagu
948:Takashi Sugimura
882:Xavier Le Pichon
827:Donald Henderson
823:Georges Vendryes
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416:"Nicholas Lydon"
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216:and in 2012 the
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50:27 February 1957
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1564:Stephen Simpson
1514:Stephen P. Long
1509:Guy Lloyd-Jones
1439:Michael Burrows
1434:Gilles Brassard
1392:
1379:
1349:
1344:
1339:Ronald M. Evans
1325:Karl Deisseroth
1321:Gero Miesenböck
1293:Bert Vogelstein
1289:Martin A. Green
1267:
1248:Max Dale Cooper
1234:Jennifer Doudna
1206:Yutaka Takahasi
1128:
1075:Erkki Ruoslahti
1057:Akira Fujishima
1025:Tim Berners-Lee
993:
988:Don Craig Wiley
874:W. Jason Morgan
858:
817:Theodore Maiman
803:Willem J. Kolff
777:
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727:. Royal Society
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387:protein kinases
327:Charles Sawyers
312:Kettering Prize
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274:Schering-Plough
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198:/nicholas-lydon
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151:Schering-Plough
127:
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58:Alma mater
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1539:Gareth Roberts
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1519:Nicholas Lydon
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1474:Melvyn Goodale
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1258:Yoshio Okamoto
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1252:Jacques Miller
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1200:C. David Allis
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1176:Nicholas Lydon
1165:
1154:Dennis Ritchie
1147:
1144:Peter Vitousek
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1119:Dennis Meadows
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1109:Robert E. Kahn
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1095:Peter GrĂĽnberg
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1061:John H. Lawton
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1043:James A. Yorke
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839:Luc Montagnier
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809:Henry Beachell
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799:David Turnbull
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789:John R. Pierce
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677:(PhD thesis).
660:
649:on 17 May 2013
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614:(1): 139–145.
597:
570:(5): 561–566.
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546:Nicholas Lydon
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378:drug discovery
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1666:Elliott Lieb
1614:Robert Young
1529:Paul O'Brien
1518:
1494:Phil Hawkins
1489:Joanna Haigh
1479:Martin Green
1464:Nigel Glover
1283:Svante Pääbo
1220:Hideo Hosono
1190:Jean Fréchet
1175:
1172:Brian Druker
1168:Janet Rowley
1150:Ken Thompson
1067:Makoto Nagao
1029:Anne McLaren
970:Jozef Schell
898:Gerhard Ertl
892:John J. Wild
878:Dan McKenzie
843:Robert Gallo
835:Frank Fenner
813:Gurdev Khush
731:12 September
729:. Retrieved
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338:Janet Rowley
323:Brian Druker
271:
250:biochemistry
235:
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192:royalsociety
170:
139:Institutions
132:
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1718:1957 births
1661:Eric Kandel
1630:Bill Bryson
1604:Terry Wyatt
1569:Terry Speed
1549:John Savill
1499:Edith Heard
1424:Mervyn Bibb
1091:Albert Fert
1047:Seiji Ogawa
908:Frank Press
774:Japan Prize
653:13 February
490:13 February
426:13 February
391:undruggable
334:Japan Prize
310:Charles F.
218:Japan Prize
116:Japan Prize
1712:Categories
1559:Paul Sharp
1544:Kerry Rowe
1524:Anne Mills
1419:Mike Bevan
1414:Keith Ball
1262:Rattan Lal
1238:Adi Shamir
1085:Akira Endo
1005:Ian McHarg
952:Bruce Ames
831:Isao Arita
776:recipients
402:References
156:Ciba-Geigy
92:AnaptysBio
46:1957-02-27
1449:Ara Darzi
1105:Vint Cerf
966:Leo Esaki
942:Masao Ito
451:16 August
276:based in
252:from the
232:Education
1651:Chen Zhu
1623:Honorary
1388:elected
671:(1982).
620:10991971
592:36102747
533:11287972
382:oncogene
246:Scotland
1639:Foreign
1397:Fellows
1390:in 2013
1384:of the
1382:Fellows
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395:R&D
360:reads:
346:, 2013.
340:, 2012.
329:, 2009.
321:, with
307:, 2002.
300:, 2000.
258:England
222:Gleevec
196:/people
187:Website
88:Gleevec
1341:(2024)
1327:(2023)
1313:(2022)
1299:(2021)
1285:(2020)
1264:(2019)
1254:(2018)
1240:(2017)
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1021:(2001)
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930:Jr. /
924:(1994)
914:(1993)
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795:(1985)
709:29 May
705:. 2013
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486:. 2012
422:. 2010
352:, 2014
278:France
268:Career
177:(1982)
175:
166:Thesis
124:(2013)
118:(2012)
112:(2009)
103:Awards
1690:Royal
1272:2020s
1133:2010s
998:2000s
863:1990s
782:1980s
588:S2CID
286:Amgen
242:Perth
240:near
146:Amgen
73:(PhD)
67:(BSc)
733:2013
711:2013
655:2013
616:PMID
580:PMID
529:PMID
492:2013
453:2010
428:2013
372:and
332:The
325:and
317:The
194:.org
40:Born
612:295
572:doi
519:doi
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210:FRS
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