363:
340:
38:
29:
1437:
626:
larvae, as a molluscide, and as a general purpose piscicide in aquaculture. Niclosamide has a short half-life in water in field conditions; this makes it valuable in ridding commercial fish ponds of unwanted fish; it loses its activity soon enough to permit re-stocking within a few days of
621:
Niclosamide's metabolic effects are relevant to a wide ranges of organisms, and accordingly it has been applied as a control measure to organisms other than tapeworms. For example, it is an active ingredient in some formulations such as
Bayluscide for killing
592:
is a preferable and equally effective treatment for tapeworm infestation. Important Note: Niclosamide kills the pork tapeworm and results in its digestion. This then may cause a multitude of viable eggs to be released and may result in
2224:
1061:
90:
506:
60:
462:
438:
597:. Therefore, a purge should be given 1 or two hours after treatment. CNS cysticercosis is a life-threatening condition and may require brain surgery.
960:
1469:
1937:
1753:
1604:
2160:
1335:
892:
795:
764:
573:
1410:
770:
1069:
801:
588:, and itchiness. Rarely, dizziness, skin rash, drowsiness, perianal itching, or an unpleasant taste occur. For some of these reasons,
2209:
2214:
1372:
735:
482:
1029:
1984:
1899:
133:
1555:
561:
Side effects include nausea, vomiting, abdominal pain, and itchiness. It may be used during pregnancy. It works by blocking
1427:
1090:
686:
639:
Niclosamide is under investigation for applications against types of cancer, bacterial infections, or viral infections.
239:
2177:
2101:
1462:
1274:"The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1"
319:
1354:
815:
713:
566:
2219:
1503:
1447:
908:
Weinbach EC, Garbus J (March 1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation".
627:
eradicating the previous population. Researchers have found that niclosamide is effective in killing invasive
2165:
78:
967:
843:
358:
2204:
1455:
1115:
Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, et al. (April 2015). Planet PJ (ed.).
1966:
37:
308:
2109:
1993:
1228:
1128:
1000:
917:
490:
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
2229:
2142:
1830:
335:
154:
2059:
1693:
1418:
991:
Verdel K.Dawson (2003). "Environmental Fate and
Effects of the Lampricide Bayluscide: a Review".
941:
539:
2030:
2021:
752:
2026:
1368:
1331:
1303:
1254:
1197:
1156:
1117:"Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus"
933:
888:
866:
791:
785:
760:
731:
50:
1272:
Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, et al. (March 2018).
288:
2004:
1972:
1494:
1358:
1293:
1285:
1244:
1236:
1187:
1146:
1136:
1008:
925:
823:
721:
375:
1390:
1346:
887:(14th ed.). Rahway: Merck Sharp & Dohme Research Laboratories. 1982. p. 176.
248:
2127:
1836:
1776:
1564:
1543:
1517:
1441:
610:
228:
113:
1402:
1232:
1132:
1036:
1004:
921:
362:
339:
163:
2171:
2137:
2095:
1882:
1762:
1595:
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1273:
1249:
1216:
1151:
1116:
562:
543:
1012:
2198:
1903:
1856:
1790:
1718:
1677:
1537:
1478:
594:
449:
351:
1215:
Braga L, Ali H, Secco I, Chiavacci E, Neves G, Goldhill D, et al. (June 2021).
1192:
1176:"Niclosamide inhibits hepatitis E virus through suppression of NF-kappaB signalling"
1175:
1933:
1887:
1877:
1872:
1810:
1804:
1749:
1646:
1600:
1490:
1486:
1482:
945:
628:
589:
585:
531:
108:
103:
98:
751:
Lanusse CE, Alvarez LI, Sallovitz JM, Mottier ML, Sanchez Bruni SF (13 May 2013).
1141:
662:
188:
2081:
1867:
1862:
1724:
1610:
1570:
1240:
1030:"WHO Specifications And Evaluations. For Public Health Pesticides. Niclosamide"
2122:
2073:
2054:
1962:
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1912:
1796:
1782:
1698:
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1652:
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414:
219:
70:
870:
2087:
1928:
1918:
1743:
1672:
1624:
1589:
1512:
1217:"Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia"
551:
547:
535:
64:
20:
1307:
1289:
1258:
1201:
1160:
820:
World Health
Organization model list of essential medicines: 21st list 2019
937:
2132:
2067:
2016:
1999:
1665:
1632:
1351:
WHO model prescribing information : drugs used in parasitic diseases
555:
199:
828:
208:
28:
2115:
2011:
1847:
1709:
1528:
1363:
726:
666:
623:
606:
174:
1174:
Li Y, Li P, He Q, Zhang R, Li Y, Kamar N, et al. (January 2022).
929:
1618:
299:
576:. Niclosamide is not available for human use in the United States.
268:
643:
437:
428:
279:
259:
1451:
1417:. U.S. National Library of Medicine. 1995-06-23. Archived from
1062:"Researchers find new methods to combat invasive zebra mussels"
642:
In 2018, niclosamide was observed to be a potent activator of
324:
832:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
572:
Niclosamide was first synthesized in 1958. It is on the
584:
Side effects include nausea, vomiting, abdominal pain,
574:
513:
1347:"Helminths: Cestode (tapeworm) infection: Niclosamide"
790:. Springer Science & Business Media. p. 483.
679:"Niclosamide Advanced Patient Information - Drugs.com"
1425:
865:(16th ed.). Easton: Mack Pub. Co. p. 1182.
848:
U.S. Centers for
Disease Control and Prevention (CDC)
2042:
1983:
1898:
1845:
1829:
1735:
1707:
1692:
1581:
1554:
1526:
1511:
1502:
720:. World Health Organization. pp. 81, 87, 591.
448:
426:
413:
374:
369:
350:
318:
298:
278:
258:
238:
218:
198:
173:
153:
124:
89:
77:
59:
49:
44:
1411:"MedlinePlus Drug Information: Niclosamide (Oral)"
550:. It is not effective against other worms such as
844:"Dipylidium – Resources for Health Professionals"
187:
716:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
162:
2225:World Health Organization essential medicines
1463:
1330:(19th ed.). Philadelphia: F.A.Davis Co.
8:
613:, and anaerobic metabolism in the tapeworm.
145:-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
19:
1406:in the Pesticide Properties DataBase (PPDB)
112:
1842:
1704:
1523:
1508:
1470:
1456:
1448:
361:
338:
227:
36:
27:
1362:
1297:
1248:
1191:
1150:
1140:
1024:
1022:
885:The Merck Manual of Diagnosis and Therapy
827:
725:
708:
706:
704:
247:
757:Veterinary Pharmacology and Therapeutics
71:Micromedex Detailed Consumer Information
1432:
773:from the original on 10 September 2017.
759:. John Wiley & Sons. p. 1096.
655:
487:
467:
454:225 to 230 °C (437 to 446 °F)
334:
207:
138:
352:
18:
1328:Taber's Cyclopedic Medical Cictionary
1326:Taber CW, Venes D, Thomas CL (2001).
822:. Geneva: World Health Organization.
689:from the original on 20 December 2016
307:
287:
69:
7:
1397:. U.S. National Library of Medicine.
102:
55:Niclocide, Fenasal, Phenasal, others
1091:"Clinical Trials Using Niclosamide"
863:Remington's Pharmaceutical Sciences
861:Remington JP, Osol A, eds. (1980).
755:. In Riviere JE, Papich MG (eds.).
470:Clc2cc(ccc2NC(=O)c1cc(Cl)ccc1O)()=O
267:
178:
1345:World Health Organization (1995).
14:
787:Encyclopedia of Parasitology: A-M
1900:Glutamate-gated chloride channel
1435:
961:"Delivery Systems of Piscicides"
804:from the original on 2016-12-20.
398:
392:
386:
1193:10.1016/j.antiviral.2021.105228
993:Journal of Great Lakes Research
495:Key:RJMUSRYZPJIFPJ-UHFFFAOYSA-N
404:
380:
1:
1013:10.1016/S0380-1330(03)70509-7
646:in primary cortical neurons.
1142:10.1371/journal.pone.0124595
526:, sold under the brand name
1060:Blank L (30 October 2018).
2246:
1938:+esafoxolaner/praziquantel
1754:+esafoxolaner/eprinomectin
1605:+esafoxolaner/eprinomectin
1241:10.1038/s41586-021-03491-6
370:Chemical and physical data
2210:Chlorobenzene derivatives
2155:
1504:Antiplatyhelmintic agents
1355:World Health Organization
999:(Supplement 1): 475–492.
816:World Health Organization
714:World Health Organization
567:oxidative phosphorylation
534:medication used to treat
503:
478:
458:
129:
35:
26:
2215:Nitrobenzene derivatives
718:WHO Model Formulary 2008
558:. It is taken by mouth.
538:infestations, including
1395:Drug Information Portal
1290:10.1002/cbic.201700500
753:"Antinematodal Drugs"
644:PTEN-induced kinase 1
605:Niclosamide inhibits
2110:naphthalenesulfonate
1994:tetrahydropyrimidine
1831:Antinematodal agents
530:among others, is an
2143:Tetrachloroethylene
1233:2021Natur.594...88B
1133:2015PLoSO..1024595R
1066:The Minnesota Daily
1005:2003JGLR...29..475D
959:Boogaard, Michael.
922:1969Natur.221.1016W
916:(5185): 1016–1018.
784:Mehlhorn H (2008).
601:Mechanism of action
23:
2182:Never to phase III
2060:Diethylcarbamazine
1180:Antiviral Research
617:Other applications
609:uptake, oxidative
540:diphyllobothriasis
2192:
2191:
2151:
2150:
1825:
1824:
1821:
1820:
1688:
1687:
1337:978-0-8036-0655-5
930:10.1038/2211016a0
894:978-0-911910-03-2
797:978-3-540-48994-8
766:978-1-118-68590-7
521:
520:
439:Interactive image
320:CompTox Dashboard
16:Chemical compound
2237:
2005:pyrantel pamoate
1973:Milbemycin oxime
1843:
1837:macrofilaricides
1705:
1524:
1518:schistosomicides
1509:
1472:
1465:
1458:
1449:
1440:
1439:
1438:
1431:
1422:
1398:
1378:
1366:
1353:(2nd ed.).
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1101:
1087:
1081:
1080:
1078:
1077:
1068:. Archived from
1057:
1051:
1050:
1048:
1047:
1041:
1035:. Archived from
1034:
1026:
1017:
1016:
988:
982:
981:
979:
978:
972:
966:. Archived from
965:
956:
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858:
852:
851:
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675:
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631:in cool waters.
517:
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40:
31:
24:
22:
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2240:
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2234:
2220:Salicylanilides
2195:
2194:
2193:
2188:
2187:
2172:Clinical trials
2147:
2128:Hexylresorcinol
2038:
1979:
1894:
1835:
1833:
1817:
1731:
1696:
1684:
1577:
1565:phosphonic acid
1550:
1544:Triclabendazole
1515:
1513:Antitrematodals
1498:
1476:
1446:
1436:
1434:
1426:
1409:
1389:
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1344:
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1319:Further reading
1316:
1315:
1271:
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1266:
1227:(7861): 88–93.
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1127:(4): e0124595.
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611:phosphorylation
603:
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512:
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507:(what is this?)
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2138:Tribendimidine
2135:
2130:
2125:
2120:
2119:
2118:
2106:
2105:
2104:
2096:benzylammonium
2092:
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1883:Ciclobendazole
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1763:salicylanilide
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1596:Arpraziquantel
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1556:AChE inhibitor
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1500:
1499:
1479:Antiparasitics
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1460:
1452:
1445:
1444:
1424:
1423:
1421:on 2006-12-16.
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1384:External links
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1284:(5): 425–429.
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850:. 21 May 2020.
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544:hymenolepiasis
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2043:Other/unknown
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1904:GABA receptor
1901:
1897:
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1881:
1879:
1876:
1874:
1871:
1869:
1866:
1864:
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1858:
1857:benzimidazole
1854:
1853:
1851:
1849:
1844:
1841:
1838:
1832:
1828:
1812:
1809:
1808:
1807:
1806:
1802:
1798:
1795:
1794:
1793:
1792:
1791:butyrophenone
1788:
1784:
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1779:
1778:
1777:aminoacridine
1774:
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1767:
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1745:
1741:
1740:
1738:
1736:Other/unknown
1734:
1726:
1723:
1722:
1721:
1720:
1719:benzimidazole
1716:
1715:
1713:
1711:
1706:
1703:
1700:
1695:
1694:Anticestodals
1691:
1679:
1678:Tartar emetic
1676:
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1582:Other/unknown
1580:
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1568:
1567:
1566:
1562:
1561:
1559:
1557:
1553:
1545:
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1538:benzimidazole
1535:
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1483:Anthelmintics
1480:
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1461:
1459:
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1450:
1443:
1433:
1429:
1420:
1416:
1412:
1408:
1405:
1404:
1400:
1396:
1392:
1391:"Niclosamide"
1388:
1387:
1383:
1376:
1374:9789241401043
1370:
1365:
1360:
1356:
1352:
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1083:
1072:on 2018-11-21
1071:
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1042:on 2017-01-10
1038:
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737:9789241547659
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683:www.drugs.com
680:
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629:zebra mussels
625:
616:
614:
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608:
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596:
595:cysticercosis
591:
587:
579:
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569:by the worm.
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451:
450:Melting point
447:
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418:
416:
412:
379:
377:
373:
368:
364:
360:
357:
355:
353:ECHA InfoCard
349:
341:
337:
336:DTXSID7040362
333:
332:
330:
321:
317:
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68:
66:
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58:
54:
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48:
45:Clinical data
43:
39:
34:
30:
25:
2108:
2094:
2080:
2066:
2049:
1992:
1955:
1934:Eprinomectin
1911:
1888:Flubendazole
1878:Fenbendazole
1873:Tiabendazole
1855:
1811:Dichlorophen
1805:chlorophenol
1803:
1789:
1775:
1768:
1761:
1750:Praziquantel
1742:
1717:
1664:
1647:thioxanthone
1645:
1631:
1617:
1601:Praziquantel
1588:
1563:
1536:
1491:endectocides
1419:the original
1414:
1401:
1394:
1350:
1327:
1281:
1277:
1267:
1224:
1220:
1210:
1183:
1179:
1169:
1124:
1120:
1110:
1098:. Retrieved
1094:
1085:
1074:. Retrieved
1070:the original
1065:
1055:
1044:. Retrieved
1037:the original
996:
992:
986:
975:. Retrieved
968:the original
954:
913:
909:
903:
884:
879:
862:
856:
847:
838:
829:10665/325771
819:
810:
786:
779:
756:
746:
717:
691:. Retrieved
682:
673:
658:
641:
638:
620:
604:
590:praziquantel
586:constipation
583:
580:Side effects
571:
560:
532:anthelmintic
527:
523:
522:
511:
505:
142:
2168:from market
2082:quinolinium
1967:+fluralaner
1957:milbemycins
1913:avermectins
1868:Albendazole
1863:Mebendazole
1769:Niclosamide
1725:Albendazole
1699:taeniacides
1611:Oxamniquine
1571:Metrifonate
1415:MedlinePlus
1403:Niclosamide
1364:10665/41765
1278:ChemBioChem
727:10665/44053
524:Niclosamide
422: g·mol
359:100.000.052
125:Identifiers
51:Trade names
21:Niclosamide
2230:Pesticides
2199:Categories
2123:Ascaridole
2074:Levamisole
2055:Piperazine
2050:piperazine
1963:Moxidectin
1949:Selamectin
1944:Ivermectin
1924:Doramectin
1834:(including
1797:Desaspidin
1783:Quinacrine
1658:Lucanthone
1653:Hycanthone
1639:Niridazole
1186:: 105228.
1076:2018-11-19
1046:2019-08-07
977:2017-05-30
693:8 December
650:References
556:roundworms
427:3D model (
415:Molar mass
309:ChEMBL1448
289:CHEBI:7553
249:8KK8CQ2K8G
220:ChemSpider
155:CAS Number
134:IUPAC name
2178:Phase III
2166:Withdrawn
2102:Bephenium
2088:Pyrvinium
2031:felsantel
2022:Carbantel
1929:Emamectin
1919:Abamectin
1744:quinoline
1673:Stibophen
1668:compounds
1625:Bithionol
1590:quinoline
871:925174053
548:taeniasis
528:Niclocide
141:5-Chloro-
79:Routes of
65:Drugs.com
2133:Santonin
2068:thiazole
2027:Febantel
2017:Morantel
2000:Pyrantel
1666:antimony
1633:thiazole
1481: –
1442:Medicine
1308:29226533
1259:33827113
1202:34929248
1161:25897961
1121:PLOS ONE
1100:20 March
818:(2019).
802:Archived
771:Archived
687:Archived
663:CID 4477
635:Research
536:tapeworm
514:(verify)
200:DrugBank
109:QP52AG03
91:ATC code
85:By mouth
2116:Suramin
2012:Oxantel
1848:tubulin
1710:tubulin
1529:tubulin
1357:(WHO).
1299:5901409
1250:7611055
1229:Bibcode
1152:4405337
1129:Bibcode
1001:Bibcode
946:4209497
938:4180173
918:Bibcode
667:PubChem
624:lamprey
607:glucose
376:Formula
209:DB06803
175:PubChem
164:50-65-7
111: (
107:)
101: (
99:P02DA01
2161:WHO-EM
1846:Binds
1708:Binds
1619:phenol
1527:Binds
1489:) and
1428:Portal
1371:
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1221:Nature
1200:
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910:Nature
891:
869:
794:
763:
734:
552:flukes
546:, and
463:SMILES
420:327.12
300:ChEMBL
269:D00436
2029:(aka
1040:(PDF)
1033:(PDF)
971:(PDF)
964:(PDF)
942:S2CID
665:from
483:InChI
429:JSmol
280:ChEBI
1985:NMDA
1495:QP54
1369:ISBN
1332:ISBN
1304:PMID
1255:PMID
1198:PMID
1157:PMID
1102:2019
934:PMID
889:ISBN
867:OCLC
792:ISBN
761:ISBN
732:ISBN
695:2016
565:and
260:KEGG
240:UNII
229:4322
189:4477
61:AHFS
1487:P02
1359:hdl
1294:PMC
1286:doi
1245:PMC
1237:doi
1225:594
1188:doi
1184:197
1147:PMC
1137:doi
1095:NCI
1009:doi
926:doi
914:221
824:hdl
722:hdl
554:or
325:EPA
179:CID
114:WHO
104:WHO
2201::
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