Knowledge (XXG)

Nidogen-1

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Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (September 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules".
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McNiven, Vanda; Ito, Yoko A.; Hartley, Taila; Kernohan, Kristin; Miller, Elka; Care4Rare Canada; Armour, Christine M. (May 2019). "NID1 variant associated with occipital cephaloceles in a family expressing a spectrum of phenotypes".
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Ockleford CD, Bright N, Hubbard A, D'Lacey C, Smith J, Gardiner L, Sheikh T, Albentosa M, Turtle K (October 1993). "Micro-Trabeculae, Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes?".
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Smith J, Ockleford CD (January 1994). "Laser scanning confocal examination and comparison of nidogen (entactin) with laminin in term human amniochorion".
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Yi XY, Wayner EA, Kim Y, Fish AJ (March 1998). "Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors".
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Zimmermann K, Hoischen S, Hafner M, Nischt R (May 1995). "Genomic sequences and structural organization of the human nidogen gene (NID)".
301: 1008: 1015: 278: 1476: 1231: 1210: 1653:"The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains" 1694:"Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands" 1227: 1162: 200: 175: 52: 1890: 1206: 117: 1178: 1133:
glycoproteins. The protein interacts with several other components of basement membranes. Structurally it (along with
1905: 314: 213: 1863: 307: 206: 1821: 1526:"OMIM Entry - % 609222 - DANDY-WALKER MALFORMATION WITH OCCIPITAL CEPHALOCELE, AUTOSOMAL DOMINANT; ADDWOC" 853: 125: 1939: 834: 1944: 1595: 1856: 1146: 189: 1280:
Olsen DR, Nagayoshi T, Fazio M, Mattei MG, Passage E, Weil D, Timpl R, Chu ML, Uitto J (June 1989).
104: 1798: 1583: 149: 991: 970: 944: 923: 1828: 1790: 1755: 1715: 1674: 1633: 1575: 1567: 1507: 1458: 1409: 1373: 1338: 1303: 1282:"Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43" 1130: 1106: 1094: 97: 45: 1780: 1747: 1705: 1664: 1625: 1559: 1499: 1448: 1440: 1401: 1365: 1330: 1293: 1098: 559: 394: 325: 269: 224: 552: 369: 145: 1710: 1693: 1453: 1428: 1298: 1281: 1369: 723: 718: 713: 708: 703: 698: 693: 677: 672: 667: 662: 657: 652: 647: 631: 626: 621: 616: 611: 606: 601: 28: 1928: 1837: 1166: 1102: 588: 1802: 1587: 1817: 387: 166: 129: 153: 1267:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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to each other. It may also play a role in cell interactions with the
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Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML (August 1993).
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Chung AE, Durkin ME (1990). "Entactin: structure and function".
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Overview of all the structural information available in the
377: 542: 1651:Tran H, VanDusen WJ, Argraves WS (September 1997). 984: 963: 937: 916: 1223: 1221: 1219: 1202: 1200: 1198: 324: 223: 16:Protein-coding gene in the species Homo sapiens 1769:"Molecular architecture of basement membranes" 1228:GRCm38: Ensembl release 89: ENSMUSG00000005397 724:positive regulation of cell-substrate adhesion 1864: 8: 1552:American Journal of Medical Genetics. Part A 1600:: CS1 maint: numeric names: authors list ( 1207:GRCh38: Ensembl release 89: ENSG00000116962 632:extracellular matrix structural constituent 1871: 1857: 1849: 749: 584: 365: 264: 161: 63: 1820:at the U.S. National Library of Medicine 1784: 1709: 1668: 1452: 1297: 714:glomerular basement membrane development 678:collagen-containing extracellular matrix 1886: 1194: 1593: 18: 329: 290: 285: 228: 187: 182: 7: 481:endothelial cell of lymphatic vessel 1899:: NIDOGEN-1 G2/PERLECAN IG3 COMPLEX 1097:alongside other components such as 1767:Yurchenco PD, Schittny JC (1990). 1711:10.1111/j.1432-1033.1993.tb18086.x 1137:) connects the networks formed by 981: 960: 934: 913: 889: 870: 844: 825: 799: 780: 547: 465: 403: 382: 14: 1082:that in humans is encoded by the 704:extracellular matrix organization 1904: 1889: 1427:Yurchenco PD, Patton BL (2009). 1093:are essential components of the 699:extracellular matrix disassembly 558: 551: 313: 306: 300: 277: 212: 205: 199: 174: 27: 1914:: DOMAIN G2 OF MOUSE NIDOGEN-1 719:basement membrane organization 569:More reference expression data 531:More reference expression data 1: 1950:Extracellular matrix proteins 1740:Am. J. Respir. Cell Mol. Biol 1477:"Entrez Gene: NID1 nidogen 1" 1370:10.1016/S0143-4004(05)80240-1 1125:Nidogen-1 is a member of the 298: 197: 1394:Phil. Trans. R. Soc. Lond. B 1177:Nidogen-1 has been shown to 622:extracellular matrix binding 1935:Genes on human chromosome 1 455:subcutaneous adipose tissue 419:stromal cell of endometrium 1966: 1786:10.1096/fasebj.4.6.2180767 1445:10.2174/138161209787846766 108:, NID, nidogen 1, entactin 1884: 1841:(Mouse Nidogen-1) at the 1504:10.3109/15419069809040294 1263:"Mouse PubMed Reference:" 1245:"Human PubMed Reference:" 1163:Dandy–Walker malformation 1161:cause autosomal dominant 1054: 1049: 1045: 1038: 1022: 1009:Chr 1: 235.98 – 236.07 Mb 1003: 988: 967: 956: 941: 920: 909: 896: 892: 877: 873: 864: 851: 847: 832: 828: 819: 806: 802: 787: 783: 774: 759: 752: 748: 732: 587: 583: 566: 550: 541: 528: 477: 468: 415: 406: 376: 368: 364: 347: 334: 297: 276: 267: 263: 246: 233: 196: 173: 164: 160: 115: 112: 102: 95: 90: 71: 66: 49: 44: 39: 35: 26: 21: 1822:Medical Subject Headings 1670:10.1074/jbc.272.36.22600 1016:Chr 13: 13.61 – 13.69 Mb 497:internal carotid artery 493:external carotid artery 1752:10.1165/ajrcmb/3.4.275 1630:10.1006/jmbi.1997.1244 1406:10.1098/rstb.1993.0142 1335:10.1006/geno.1995.1038 1153:Clinical significance 1105:(heparan sulfate and 1089:. Both nidogen-1 and 1074:), formerly known as 663:extracellular exosome 331:13 A1|13 5.26 cM 292:Chromosome 13 (mouse) 1564:10.1002/ajmg.a.61095 1147:extracellular matrix 694:cell-matrix adhesion 653:extracellular region 648:extracellular matrix 627:proteoglycan binding 190:Chromosome 1 (human) 67:List of PDB id codes 40:Available structures 673:extracellular space 607:calcium ion binding 447:canal of the cervix 1492:Cell Adhes. Commun 1107:glycosaminoglycans 854:ENSMUSG00000005397 687:Biological process 641:Cellular component 595:Molecular function 485:epithelium of lens 427:lower lobe of lung 1922: 1921: 1400:(1300): 121–136. 1286:Am. J. Hum. Genet 1131:basement membrane 1095:basement membrane 1065: 1064: 1061: 1060: 1034: 1033: 999: 998: 978: 977: 952: 951: 931: 930: 905: 904: 886: 885: 860: 859: 841: 840: 815: 814: 796: 795: 744: 743: 658:basement membrane 602:laminin-1 binding 579: 578: 575: 574: 537: 536: 524: 523: 462: 461: 431:left uterine tube 360: 359: 259: 258: 86: 85: 82: 81: 50:Ortholog search: 1957: 1908: 1893: 1873: 1866: 1859: 1850: 1806: 1788: 1763: 1724: 1723: 1713: 1689: 1683: 1682: 1672: 1648: 1642: 1641: 1612: 1606: 1605: 1599: 1591: 1546: 1540: 1539: 1537: 1536: 1522: 1516: 1515: 1487: 1481: 1480: 1473: 1467: 1466: 1456: 1433:Curr. Pharm. Des 1424: 1418: 1417: 1388: 1382: 1381: 1353: 1347: 1346: 1318: 1312: 1311: 1301: 1277: 1271: 1270: 1259: 1253: 1252: 1241: 1235: 1225: 1214: 1204: 1099:type IV collagen 1047: 1046: 1018: 1011: 994: 982: 973: 961: 957:RefSeq (protein) 947: 935: 926: 914: 890: 871: 845: 826: 800: 781: 750: 617:collagen binding 585: 571: 562: 555: 548: 533: 509:trophoblast cell 501:efferent ductule 473: 471:Top expressed in 466: 411: 409:Top expressed in 404: 383: 366: 356: 343: 332: 317: 310: 304: 293: 281: 265: 255: 242: 231: 216: 209: 203: 192: 178: 162: 156: 154:NID1 - orthologs 107: 100: 77: 64: 58: 37: 36: 31: 19: 1965: 1964: 1960: 1959: 1958: 1956: 1955: 1954: 1925: 1924: 1923: 1918: 1915: 1909: 1900: 1894: 1880: 1877: 1814: 1809: 1766: 1737: 1733: 1731:Further reading 1728: 1727: 1698:Eur. J. Biochem 1691: 1690: 1686: 1663:(36): 22600–6. 1650: 1649: 1645: 1614: 1613: 1609: 1592: 1548: 1547: 1543: 1534: 1532: 1524: 1523: 1519: 1489: 1488: 1484: 1475: 1474: 1470: 1439:(12): 1277–94. 1426: 1425: 1421: 1390: 1389: 1385: 1355: 1354: 1350: 1320: 1319: 1315: 1279: 1278: 1274: 1261: 1260: 1256: 1243: 1242: 1238: 1226: 1217: 1205: 1196: 1191: 1175: 1165:with occipital 1155: 1123: 1056:View/Edit Mouse 1051:View/Edit Human 1014: 1007: 1004:Location (UCSC) 990: 969: 943: 922: 835:ENSG00000116962 728: 682: 636: 612:laminin binding 567: 557: 556: 529: 520: 515: 511: 507: 503: 499: 495: 491: 487: 483: 469: 458: 453: 449: 445: 441: 437: 433: 429: 425: 421: 407: 351: 338: 330: 320: 319: 318: 311: 291: 268:Gene location ( 250: 237: 229: 219: 218: 217: 210: 188: 165:Gene location ( 116: 103: 96: 73: 51: 17: 12: 11: 5: 1963: 1961: 1953: 1952: 1947: 1942: 1940:Human proteins 1937: 1927: 1926: 1920: 1919: 1917: 1916: 1910: 1903: 1901: 1895: 1888: 1885: 1882: 1881: 1878: 1876: 1875: 1868: 1861: 1853: 1847: 1846: 1825: 1813: 1812:External links 1810: 1808: 1807: 1779:(6): 1577–90. 1764: 1734: 1732: 1729: 1726: 1725: 1684: 1643: 1607: 1558:(5): 837–841. 1541: 1517: 1482: 1468: 1419: 1383: 1348: 1313: 1272: 1254: 1236: 1215: 1193: 1192: 1190: 1187: 1174: 1171: 1154: 1151: 1122: 1119: 1063: 1062: 1059: 1058: 1053: 1043: 1042: 1036: 1035: 1032: 1031: 1029: 1027: 1020: 1019: 1012: 1005: 1001: 1000: 997: 996: 986: 985: 979: 976: 975: 965: 964: 958: 954: 953: 950: 949: 939: 938: 932: 929: 928: 918: 917: 911: 907: 906: 903: 902: 894: 893: 887: 884: 883: 875: 874: 868: 862: 861: 858: 857: 849: 848: 842: 839: 838: 830: 829: 823: 817: 816: 813: 812: 804: 803: 797: 794: 793: 785: 784: 778: 772: 771: 766: 761: 757: 756: 746: 745: 742: 741: 730: 729: 727: 726: 721: 716: 711: 706: 701: 696: 690: 688: 684: 683: 681: 680: 675: 670: 668:cell periphery 665: 660: 655: 650: 644: 642: 638: 637: 635: 634: 629: 624: 619: 614: 609: 604: 598: 596: 592: 591: 581: 580: 577: 576: 573: 572: 564: 563: 545: 539: 538: 535: 534: 526: 525: 522: 521: 519: 518: 514: 510: 506: 505:left lung lobe 502: 498: 494: 490: 486: 482: 478: 475: 474: 463: 460: 459: 457: 456: 452: 448: 444: 440: 436: 432: 428: 424: 423:gastric mucosa 420: 416: 413: 412: 400: 399: 391: 380: 374: 373: 370:RNA expression 362: 361: 358: 357: 349: 345: 344: 336: 333: 328: 322: 321: 312: 305: 299: 295: 294: 289: 283: 282: 274: 273: 261: 260: 257: 256: 248: 244: 243: 235: 232: 227: 221: 220: 211: 204: 198: 194: 193: 186: 180: 179: 171: 170: 158: 157: 114: 110: 109: 101: 93: 92: 88: 87: 84: 83: 80: 79: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1962: 1951: 1948: 1946: 1945:Glycoproteins 1943: 1941: 1938: 1936: 1933: 1932: 1930: 1913: 1907: 1902: 1898: 1892: 1887: 1883: 1874: 1869: 1867: 1862: 1860: 1855: 1854: 1851: 1844: 1840: 1839: 1834: 1830: 1826: 1823: 1819: 1816: 1815: 1811: 1804: 1800: 1796: 1792: 1787: 1782: 1778: 1774: 1770: 1765: 1761: 1757: 1753: 1749: 1746:(4): 275–82. 1745: 1741: 1736: 1735: 1730: 1721: 1717: 1712: 1707: 1704:(3): 733–40. 1703: 1699: 1695: 1688: 1685: 1680: 1676: 1671: 1666: 1662: 1658: 1657:J. Biol. Chem 1654: 1647: 1644: 1639: 1635: 1631: 1627: 1624:(2): 226–36. 1623: 1619: 1611: 1608: 1603: 1597: 1589: 1585: 1581: 1577: 1573: 1569: 1565: 1561: 1557: 1553: 1545: 1542: 1531: 1527: 1521: 1518: 1513: 1509: 1505: 1501: 1498:(3): 237–48. 1497: 1493: 1486: 1483: 1478: 1472: 1469: 1464: 1460: 1455: 1450: 1446: 1442: 1438: 1434: 1430: 1423: 1420: 1415: 1411: 1407: 1403: 1399: 1395: 1387: 1384: 1379: 1375: 1371: 1367: 1364:(1): 95–106. 1363: 1359: 1352: 1349: 1344: 1340: 1336: 1332: 1329:(2): 245–50. 1328: 1324: 1317: 1314: 1309: 1305: 1300: 1295: 1292:(6): 876–85. 1291: 1287: 1283: 1276: 1273: 1268: 1264: 1258: 1255: 1250: 1246: 1240: 1237: 1233: 1229: 1224: 1222: 1220: 1216: 1212: 1208: 1203: 1201: 1199: 1195: 1188: 1186: 1184: 1180: 1172: 1170: 1168: 1167:encephalocele 1164: 1160: 1157:Mutations in 1152: 1150: 1148: 1144: 1140: 1136: 1132: 1128: 1120: 1118: 1116: 1112: 1108: 1104: 1103:proteoglycans 1100: 1096: 1092: 1088: 1085: 1081: 1077: 1073: 1069: 1057: 1052: 1048: 1044: 1041: 1037: 1030: 1028: 1025: 1021: 1017: 1013: 1010: 1006: 1002: 995: 993: 987: 983: 980: 974: 972: 966: 962: 959: 955: 948: 946: 940: 936: 933: 927: 925: 919: 915: 912: 910:RefSeq (mRNA) 908: 901: 900: 895: 891: 888: 882: 881: 876: 872: 869: 867: 863: 856: 855: 850: 846: 843: 837: 836: 831: 827: 824: 822: 818: 811: 810: 805: 801: 798: 792: 791: 786: 782: 779: 777: 773: 770: 767: 765: 762: 758: 755: 751: 747: 740: 736: 731: 725: 722: 720: 717: 715: 712: 710: 709:cell adhesion 707: 705: 702: 700: 697: 695: 692: 691: 689: 686: 685: 679: 676: 674: 671: 669: 666: 664: 661: 659: 656: 654: 651: 649: 646: 645: 643: 640: 639: 633: 630: 628: 625: 623: 620: 618: 615: 613: 610: 608: 605: 603: 600: 599: 597: 594: 593: 590: 589:Gene ontology 586: 582: 570: 565: 561: 554: 549: 546: 544: 540: 532: 527: 516: 513:Gonadal ridge 512: 508: 504: 500: 496: 492: 488: 484: 480: 479: 476: 472: 467: 464: 454: 450: 446: 442: 438: 434: 430: 426: 422: 418: 417: 414: 410: 405: 402: 401: 398: 396: 392: 390: 389: 385: 384: 381: 379: 375: 371: 367: 363: 355: 350: 346: 342: 337: 327: 323: 316: 309: 303: 296: 288: 284: 280: 275: 271: 266: 262: 254: 249: 245: 241: 236: 226: 222: 215: 208: 202: 195: 191: 185: 181: 177: 172: 168: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 111: 106: 99: 94: 89: 78: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 1911: 1896: 1836: 1776: 1772: 1743: 1739: 1701: 1697: 1687: 1660: 1656: 1646: 1621: 1618:J. Mol. Biol 1617: 1610: 1596:cite journal 1555: 1551: 1544: 1533:. Retrieved 1530:www.omim.org 1529: 1520: 1495: 1491: 1485: 1471: 1436: 1432: 1422: 1397: 1393: 1386: 1361: 1357: 1351: 1326: 1322: 1316: 1289: 1285: 1275: 1266: 1257: 1248: 1239: 1176: 1173:Interactions 1158: 1156: 1124: 1083: 1075: 1071: 1067: 1066: 989: 968: 942: 921: 897: 878: 852: 833: 807: 788: 768: 763: 393: 386: 251:236,065,109 238:235,975,830 113:External IDs 72: 1879:PDB gallery 1115:fibronectin 439:pericardium 352:13,686,854 339:13,612,136 91:Identifiers 1929:Categories 1535:2020-01-06 1234:, May 2017 1213:, May 2017 1189:References 1169:(ADDWOC). 1129:family of 489:epididymis 435:right lung 397:(ortholog) 134:HomoloGene 1572:1552-4833 1139:collagens 1091:nidogen-2 1068:Nidogen-1 992:NP_035047 971:NP_002499 945:NM_010917 924:NM_002508 754:Orthologs 142:GeneCards 1803:18724722 1588:73507129 1580:30773799 1463:19355968 1358:Placenta 1323:Genomics 1230:– 1209:– 1179:interact 1143:laminins 1135:perlecan 1121:Function 1076:entactin 1040:Wikidata 733:Sources: 451:placenta 1843:PDBe-KB 1833:UniProt 1818:Nidogen 1795:2180767 1773:FASEB J 1760:2119632 1720:8354280 1679:9278415 1638:9299350 1512:9686320 1454:2978668 1414:7904354 1378:8208674 1343:7557988 1308:2471408 1299:1715653 1232:Ensembl 1211:Ensembl 1127:nidogen 1111:laminin 1080:protein 1078:, is a 866:UniProt 821:Ensembl 760:Species 739:QuickGO 443:pylorus 372:pattern 98:Aliases 1838:P10493 1824:(MeSH) 1801:  1793:  1758:  1718:  1677:  1636:  1586:  1578:  1570:  1510:  1461:  1451:  1412:  1376:  1341:  1306:  1296:  1026:search 1024:PubMed 899:P10493 880:P14543 776:Entrez 543:BioGPS 517:dermis 230:1q42.3 122:131390 1799:S2CID 1584:S2CID 1183:FBLN1 1181:with 1072:NID-1 809:18073 769:Mouse 764:Human 735:Amigo 395:Mouse 388:Human 335:Start 270:Mouse 234:Start 167:Human 130:97342 1912:1h4u 1897:1gl4 1831:for 1791:PMID 1756:PMID 1716:PMID 1675:PMID 1634:PMID 1602:link 1576:PMID 1568:ISSN 1508:PMID 1459:PMID 1410:PMID 1374:PMID 1339:PMID 1304:PMID 1159:NID1 1141:and 1113:and 1087:gene 1084:NID1 790:4811 378:Bgee 326:Band 287:Chr. 225:Band 184:Chr. 146:NID1 138:1878 118:OMIM 105:NID1 75:1NDX 56:RCSB 53:PDBe 22:NID1 1829:PDB 1781:doi 1748:doi 1706:doi 1702:215 1665:doi 1661:272 1626:doi 1622:272 1560:doi 1556:179 1500:doi 1449:PMC 1441:doi 1402:doi 1398:342 1366:doi 1331:doi 1294:PMC 1109:), 348:End 247:End 150:OMA 126:MGI 46:PDB 1931:: 1835:: 1797:. 1789:. 1775:. 1771:. 1754:. 1742:. 1714:. 1700:. 1696:. 1673:. 1659:. 1655:. 1632:. 1620:. 1598:}} 1594:{{ 1582:. 1574:. 1566:. 1554:. 1528:. 1506:. 1494:. 1457:. 1447:. 1437:15 1435:. 1431:. 1408:. 1396:. 1372:. 1362:15 1360:. 1337:. 1327:27 1325:. 1302:. 1290:44 1288:. 1284:. 1265:. 1247:. 1218:^ 1197:^ 1185:. 1149:. 1117:. 1101:, 737:/ 354:bp 341:bp 253:bp 240:bp 148:; 144:: 140:; 136:: 132:; 128:: 124:; 120:: 1872:e 1865:t 1858:v 1845:. 1805:. 1783:: 1777:4 1762:. 1750:: 1744:3 1722:. 1708:: 1681:. 1667:: 1640:. 1628:: 1604:) 1590:. 1562:: 1538:. 1514:. 1502:: 1496:5 1479:. 1465:. 1443:: 1416:. 1404:: 1380:. 1368:: 1345:. 1333:: 1310:. 1269:. 1251:. 1070:( 272:) 169:) 152::

Index


PDB
PDBe
RCSB
1NDX
Aliases
NID1
OMIM
131390
MGI
97342
HomoloGene
1878
GeneCards
NID1
OMA
NID1 - orthologs
Human
Chromosome 1 (human)
Chr.
Chromosome 1 (human)
Chromosome 1 (human)
Genomic location for NID1
Genomic location for NID1
Band
bp
bp
Mouse
Chromosome 13 (mouse)
Chr.

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