275:(1888–1969) told of his first meeting, when Spatz applied for a position in Nissl's laboratory. Nissl was busy that morning and asked the student to come to his home at twelve. When Spatz came to the house at noon, Nissl was not there, and the housekeeper finally opined that the Professor must have meant twelve midnight, so Spatz returned that night. Nissl was at home then, but Spatz had to wait in the anteroom for half an hour until Nissl had finished the piano sonata that he was playing. The conversation lasted until daybreak.
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remained in that post from 1885 until 1888. There was a small laboratory at the castle, which enabled Nissl to continue with his neuropathological research. In 1888 Nissl moved to the
Institution Blankenheim. In 1889 he went to Frankfurt as second in position under Emil Sioli (1852–1922) at the Städtische Irrenanstalt. There he met neurologist
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Professor von Gudden was the judge in Nissl's college-essay competition, and he was so impressed with the study that he offered Nissl an assistantship at the
Furstenried castle southwest of Munich, where one of his responsibilities would be to care for the mad Prince Otto. Nissl accepted, and
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in 1884, Nissl undertook the brain-cortex study. He used alcohol as a fixative and developed a staining technique that allowed the demonstration of several new nerve-cell constituents. Nissl won the prize, and wrote his doctoral dissertation on the same topic in 1885.
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One day, for a practical joke, Nissl (who was an active campaigner against human consumption of alcohol) placed a row of empty beer bottles outside his laboratory and made sure that
Kraepelin heard that he could be found lying under his desk, dead drunk.
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In 1918 Kraepelin again invited Nissl to accept a research position at the
Deutsche Forschungsanstalt für Psychiatrie in Munich. After one year at that position, where he performed research alongside
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As soon as we agree to see in all mental derangements the clinical expression of definite disease processes in the cortex, we remove the obstacles that make impossible agreement among alienists.
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The burden of teaching and administration, combined with poor research facilities, forced Nissl to leave many scientific projects unfinished. He also suffered from a kidney disease. During
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Nissl was possibly the greatest neuropathologist of his day and also a fine clinician who popularised the use of spinal puncture, which had been introduced by
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suggested that Nissl write an essay on the pathology of the cells of the cortex of the brain. When the medical faculty offered a competition for a prize in
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Nissl was of small stature, with poor posture. He had a birthmark on his left face. He never married, and his life revolved entirely around his work.
357:) appears dark blue due to the staining of ribosomal RNA, giving the cytoplasm a mottled appearance. Individual granules of extranuclear RNA are named
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Theodor Nissl and Maria Haas. Theodor taught Latin in a Catholic school and wanted Franz to become a priest. However Franz entered the
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blue, and is used to highlight important structural features of neurons. The
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Nissl's nickname among medical students of the day was "punctator maximus"
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Nissl also examined the neural connections between the human cortex and
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An example of his research philosophy is taken from his 1896 writings:
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Nissl was
Alzheimer's best man at the latter's wedding in April 1894
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he was charged with administering a large military hospital.
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More information from the
University of Illinois at Chicago
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Image of a Nissl-stained histological section through the
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is the staining of the cell body, and in particular
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413:Biography of Franz Nissl, accessed 1 November 2009
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212:In Frankfurt Nissl became acquainted with
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27:German psychiatrist and medical researcher
163:One of Nissl's university professors was
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472:Nissl staining method and protocol link
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160:. Later, he specialized in Psychiatry.
154:Ludwig Maximilian University of Munich
403:from the original on 28 February 2014
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265:Nissl was a competent pianist.
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463:Works by or about Franz Nissl
355:rough endoplasmic reticulum
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397:"Whonamedit - Franz Nissl"
169:Sigbert Josef Maria Ganser
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369:stains a similar color.
321:Named histology concepts
225:University of Heidelberg
502:History of neuroscience
497:German neuroscientists
365:). DNA present in the
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120:(9 September 1860, in
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331:endoplasmic reticulum
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189:and neuropathologist
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55:Franz Alexander Nissl
231:Later life and death
165:Bernhard von Gudden
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248:Walther Spielmeyer
244:Korbinian Brodmann
167:. His assistant,
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314:hippocampus
237:World War I
195:glial cells
150:Frankenthal
122:Frankenthal
69:Frankenthal
36:Franz Nissl
18:Nissl stain
481:Categories
383:References
273:Hugo Spatz
144:Early life
61:1860-09-09
432:Biography
363:ribosomes
270:physician
173:neurology
156:to study
102:Signature
407:19 April
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373:See also
339:thionine
254:Personal
219:In 1895
158:medicine
465:at the
367:nucleus
335:aniline
311:rodent
279:Legacy
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