276:
2409:
2430:
255:
51:
266:
560:
Nitrates mainly differ in speed and duration of their action. Glyceryl trinitrate acts fast and short (10 to 30 minutes), while most other nitrates have a slower onset of action, but are effective for up to six hours. Molsidomine, as has been mentioned, not only acts slowly but also differs from the
344:
depends on its speed of action: Fast acting substances such as glyceryl trinitrate and nitroprusside can be helpful for controlling blood pressure and consequently the amount of blood the heart has to pump, if the application is monitored continuously. Slow acting substances would hold the danger of
896:
Cheitlin, M. D.; Hutter Jr, A. M.; Brindis, R. G.; Ganz, P.; Kaul, S.; Russell Jr, R. O.; Zusman, R. M.; Forrester, J. S.; Douglas, P. S.; Faxon, D. P.; Fisher, J. D.; Gibbons, R. J.; Halperin, J. L.; Hutter, A. M.; Hochman, J. S.; Kaul, S.; Weintraub, W. S.; Winters, W. L.; Wolk, M. J. (1999).
816:
Tanaka, Y.; Tang, G.; Takizawa, K.; Otsuka, K.; Eghbali, M.; Song, M.; Nishimaru, K.; Shigenobu, K.; Koike, K.; Stefani, E.; Toro, L. (2005). "Kv
Channels Contribute to Nitric Oxide- and Atrial Natriuretic Peptide-Induced Relaxation of a Rat Conduit Artery".
529:, meaning that repeated application results in a fast decrease of effect, usually within 24 hours. A pause of six to eight hours restores the original effectiveness. This phenomenon was originally thought to be a consequence of depletion of
349:
due to an uncontrollably low blood pressure and are therefore contraindicated. Depending on the circumstances, even fast acting substances can be contraindicated – for example, glyceryl trinitrate in patients with obstructive heart failure.
533:(–SH) groups necessary for the reduction of nitrates. While this theory would fit the fact that molsidomine (which is not reduced) does not exhibit tachyphylaxis, it has meanwhile been refuted. Newer theories include increase of
1239:
327:
Nitrovasodilators are contraindicated under circumstances where lowering of blood pressure can be dangerous. This includes, with some variation between the individual substances, severe hypotension (low blood pressure),
860:
Webb, D. J.; Freestone, S.; Allen, M. J.; Muirhead, G. J. (1999). "Sildenafil citrate and blood-pressure-lowering drugs: Results of drug interaction studies with an organic nitrate and a calcium antagonist".
955:
369:
Most side effects are direct consequences of the vasodilation and the resultant low blood pressure. They include headache ("nitrate headache") resulting from the widening of blood vessels in the brain,
1232:
517:. In combination with the increased cGMP production caused by nitrovasodilators, this leads to high concentrations of cGMP, extensive venous pooling, and potentially life-threatening hypotension.
3071:
561:
nitrates in exhibiting no tolerance. Nitroprusside, given intravenously, acts immediately, and after stopping the infusion blood pressure returns to its previous level within ten minutes.
1225:
2361:
1441:
82:
2467:
948:
3064:
2418:
784:
941:
899:"ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association"
456:
by various mechanisms. Nitrates undergo chemical reduction, likely mediated by enzymes. Molsidomine and nitroprusside already contain nitrogen in the right
4204:
1431:
3057:
2212:
2690:
1409:
2460:
506:. Lower preload and afterload result in the heart needing less energy and thus less oxygen. Besides, NO donated by nitrovasodilators can reduce
1785:
1375:
1183:
727:
691:
661:
2072:
2065:
575:
2172:
3833:
1815:
4259:
2453:
1678:
570:
258:
3518:
1360:
494:, which increases their capacity to hold blood ("venous pooling") and reduces the pressure of the blood returning to the heart (the
3684:
381:
Occasionally, severe hypotension occurs shortly after beginning of treatment, possibly resulting in intensified angina symptoms or
3871:
3197:
289:, while molsidomine acts too slowly to be useful for the treatment of acute angina. For quick action in the treatment of angina,
3488:
1968:
1424:
3593:
4391:
4273:
596:"Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase"
468:
3955:
3823:
2603:
2980:
1667:
4361:
3523:
3347:
2735:
2713:
1449:
1026:
989:
206:
2975:
4209:
4020:
3493:
3233:
2720:
2278:
1392:
1200:
286:
171:
4092:
3978:
3911:
3778:
3357:
2801:
1928:
1417:
3243:
3131:
3005:
2962:
2952:
2828:
2808:
2772:
2695:
2655:
2476:
402:
294:
4050:
3924:
3841:
3483:
378:, dizziness, nausea and vomiting. These effects usually subside after a few days if the treatment is continued.
2823:
2813:
2703:
1325:
200:
3738:
397:
A number of drugs add to the low blood pressure caused by nitrovasodilators: for example, other vasodilators,
4030:
3861:
3728:
722:(in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. pp. 5417–8, 5426–9, 5784–5.
4290:
3901:
3818:
3550:
3362:
3238:
3010:
2942:
2887:
2788:
2708:
2592:
2570:
1983:
1661:
1512:
1380:
1349:
1188:
4190:
4097:
3846:
3578:
2550:
4287:
3991:
3937:
3800:
3787:
3545:
3248:
2947:
2937:
2851:
2597:
2555:
2020:
1775:
1001:
472:
182:
3906:
3508:
3478:
4396:
4386:
4214:
3896:
3711:
3498:
2796:
1705:
1641:
1486:
1217:
778:
398:
341:
155:
3851:
3555:
3503:
3327:
3322:
4136:
3733:
3473:
3342:
3332:
3748:
3743:
3573:
3560:
3513:
3337:
3263:
3253:
2545:
2528:
1780:
1760:
1629:
1285:
1274:
995:
495:
279:
243:
186:
176:
4224:
4154:
2892:
2730:
2725:
2560:
2533:
2389:
2125:
1911:
1690:
1517:
514:
410:
329:
312:
290:
3172:
2429:
4381:
3891:
3876:
3654:
3634:
3603:
3455:
3412:
3177:
3157:
3152:
3147:
3086:
3000:
2865:
2618:
2423:
2288:
2147:
1601:
842:
382:
375:
371:
4159:
3950:
3881:
3629:
3608:
216:
4035:
3768:
3162:
3142:
933:
4070:
4065:
3679:
3674:
3598:
3432:
3293:
3288:
3283:
3278:
3122:
2636:
2608:
2588:
2384:
2167:
2157:
2060:
1890:
1846:
1830:
1634:
1624:
1567:
1557:
920:
878:
834:
766:
723:
687:
657:
656:(in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 554–558.
617:
464:
429:
333:
236:
99:
94:
4060:
4055:
4045:
4025:
3758:
3273:
4106:
3700:
3669:
3583:
3534:
3427:
3378:
3258:
2985:
2580:
2394:
2217:
2142:
2130:
2055:
1921:
1800:
1589:
1252:
1006:
910:
870:
826:
802:
756:
607:
534:
476:
437:
191:
3856:
3468:
4294:
3965:
3753:
3588:
3352:
2835:
2565:
2445:
2434:
2379:
2248:
2243:
2082:
2015:
2010:
1896:
1842:
1683:
1574:
1527:
1031:
968:
542:
457:
425:
211:
136:
71:
487:
levels, leading to relaxation of the muscle cells and thus to dilation of blood vessels.
421:(Viagra), is contraindicated because potentially life-threatening hypotension may occur.
275:
4314:
3973:
3866:
3763:
3463:
3450:
3437:
3083:
2995:
2920:
2912:
2506:
2493:
2413:
2313:
2308:
2162:
2152:
2102:
2087:
2077:
1978:
1973:
1963:
1901:
1873:
1825:
1820:
1552:
1507:
1503:
1386:
1194:
545:
507:
433:
354:
87:
915:
898:
874:
4375:
4255:
4004:
3813:
3442:
3422:
3417:
3402:
2613:
2523:
2516:
2501:
2345:
2318:
2177:
1995:
1906:
1886:
1882:
1745:
1673:
1562:
1477:
1300:
761:
744:
538:
526:
480:
406:
316:
304:
143:
128:
3049:
846:
4332:
4308:
3639:
3407:
3107:
3094:
3080:
3027:
3017:
2990:
2879:
2870:
2667:
2641:
2303:
2222:
1958:
1916:
1750:
1740:
1656:
1651:
1315:
1256:
1249:
1129:
1074:
972:
453:
298:
132:
124:
75:
55:
1861:
17:
4345:
4116:
4040:
3649:
3644:
3529:
3370:
3268:
3112:
3032:
3022:
2750:
2745:
2740:
2651:
2187:
2097:
1837:
1790:
1735:
1618:
1584:
1310:
1305:
1294:
1154:
1119:
1079:
1058:
1039:
1016:
1011:
964:
386:
308:
269:
239:
232:
224:
151:
4318:
4298:
4232:
3886:
3303:
3298:
3187:
3167:
2970:
2755:
2645:
2628:
2511:
2365:
2336:
2294:
2263:
2258:
2197:
2192:
2182:
2120:
2106:
2046:
2001:
1949:
1869:
1865:
1806:
1766:
1721:
1717:
1607:
1543:
1493:
1458:
1454:
1169:
1149:
1144:
1139:
1134:
1114:
1109:
1089:
1021:
549:
418:
358:
196:
50:
41:
4304:
4263:
4126:
4121:
3182:
2902:
2673:
2540:
2273:
2253:
2227:
2202:
2137:
2115:
1943:
1856:
1730:
1339:
1334:
1159:
1124:
1104:
1084:
1049:
830:
612:
595:
503:
346:
882:
838:
621:
254:
4338:
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
924:
770:
353:
These drugs are also contraindicated in patients that have recently taken
4325:
4281:
4267:
4182:
4084:
3773:
3664:
3211:
3102:
2930:
2661:
2374:
2238:
2234:
2207:
1646:
1579:
1498:
1164:
1099:
499:
467:
in the smooth muscle cells of blood vessels. Guanylate cyclase produces
265:
166:
Here is a list of examples of the nitrate type (in alphabetical order):
111:
4245:
4111:
3624:
3619:
3568:
3387:
3382:
3308:
3228:
3217:
2925:
2350:
2268:
1933:
1700:
1522:
1472:
1094:
484:
449:
440:. This interaction is not described for non-nitrate nitrovasodilators.
414:
340:. Whether a specific drug is useful or harmful under heart failure and
337:
594:
Brandes RP, Kim D, Schmitz-Winnenthal FH, et al. (January 2000).
4341:
4237:
4131:
3694:
2765:
2760:
2032:
1695:
686:(in German). Stuttgart: Deutscher Apotheker Verlag. pp. 257–61.
285:
The nitrates are used for the treatment and prevention of angina and
502:
also reduces the pressure against which the heart has to pump, the
2897:
2484:
2332:
2042:
1537:
530:
274:
264:
253:
147:
4219:
4146:
3720:
2036:
525:
Nitrates exhibit development of tolerance, or more specifically
491:
3053:
2449:
1413:
1221:
937:
483:
various proteins that play a role in decreasing intracellular
135:(NO), and is mostly used for the treatment and prevention of
552:
as the blood vessels' reaction to NO-mediated vasodilation.
246:. These substances do not need to be reduced to donate NO.
475:(GTP). cGMP in turn activates cyclic nucleotide-dependent
796:
794:
513:
PDE5 inhibitors block deactivation of cGMP by the enzyme
682:
Steinhilber, D; Schubert-Zsilavecz, M; Roth, HJ (2005).
490:
The most important effect in angina is the widening of
27:
Drug that causes vasodilation by releasing nitric oxide
3103:
Nitroxyl anion (NO; oxonitrate(1-), hyponitrite anion)
1442:
819:
158:
to NO in the body, as well as some other substances.
4172:
4145:
4083:
4013:
3964:
3832:
3719:
3710:
3693:
3594:
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
3210:
3130:
3121:
3093:
2961:
2911:
2878:
2864:
2844:
2781:
2683:
2627:
2579:
2492:
2483:
2359:
2331:
2287:
2096:
2031:
1994:
1942:
1855:
1799:
1759:
1716:
1600:
1536:
1448:
1348:
1324:
1284:
1264:
1067:
1048:
980:
105:
93:
81:
67:
62:
34:
652:Mutschler, Ernst; Schäfer-Korting, Monika (2001).
3408:Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
745:"Sodium Nitroprusside: Twenty Years and Counting"
743:Friederich, JA; Butterworth, JF 4th (July 1995).
460:(+2) and liberate NO without the aid of enzymes.
319:, and lowering of blood pressure during surgery.
231:Nitrovasodilators which aren't nitrates include
3269:Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
713:
711:
709:
707:
705:
703:
417:. Combination with PDE5 inhibitors, including
3685:N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
3244:Ethylene glycol dinitrate (EGDN; nitroglycol)
3065:
2461:
1425:
1233:
949:
903:Journal of the American College of Cardiology
677:
675:
673:
463:NO stimulates the soluble form of the enzyme
8:
1440:Major chemical drug groups – based upon the
783:: CS1 maint: numeric names: authors list (
647:
645:
643:
641:
639:
637:
635:
633:
631:
3716:
3707:
3127:
3072:
3058:
3050:
2875:
2489:
2468:
2454:
2446:
1432:
1418:
1410:
1240:
1226:
1218:
956:
942:
934:
49:
3428:Isobutyl nitrite (2-methylpropyl nitrite)
3338:Nitroglycerin (glyceryl trinitrate (GTN))
914:
760:
611:
510:, increasing the heart's oxygen supply.
3504:S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
3494:S-Nitroso-N-valerylpenicillamine (SNVP)
2477:Physiology of the cardiovascular system
586:
3489:S-Nitroso-N-acetylpenicillamine (SNAP)
3363:Sodium trioxodinitrate (Angeli's salt)
2419:Pharmacological classification systems
1786:Selective estrogen receptor modulators
776:
123:is a pharmaceutical agent that causes
31:
2066:Non-steroidal anti-inflammatory drugs
801:
432:(DHE). High DHE levels may result in
7:
4324:non-selective PDE inhibitors (e.g.,
3108:Nitric oxide (NO; nitrogen monoxide)
576:Biological functions of nitric oxide
3348:Pentaerithrityl tetranitrate (PETN)
3234:Diethylene glycol dinitrate (DEGDN)
1679:Angiotensin II receptor antagonists
537:resulting in deactivation of NO to
4253:Indirect/downstream NO modulators:
4021:Asymmetric dimethylarginine (ADMA)
863:The American Journal of Cardiology
25:
4051:Nitroarginine methyl ester (NAME)
3514:S-Nitrosoglutathione (GSNO, SNOG)
3484:S-Nitroso-N-acetylcysteine (SNAC)
3358:Propylene glycol dinitrate (PGDN)
3113:Nitrosonium (NO; nitrosyl cation)
2428:
2408:
2407:
762:10.1213/00000539-199507000-00031
3579:Diethylenetriamine/NO (DETA/NO)
1816:Hypothalamic–pituitary hormones
556:Differences in pharmacokinetics
3779:N-(1-Iminoethyl)-L-ornithine (
571:History of glyceryl trinitrate
469:cyclic guanosine monophosphate
199:(which additionally acts as a
1:
4362:Receptor/signaling modulators
4031:Guanidinoethyldisulfide (GED)
3249:Isosorbide mononitrate (ISMN)
3239:Erythritol tetranitrate (ETN)
2604:Aortic valve area calculation
1568:Thrombolytics / fibrinolytics
916:10.1016/S0735-1097(98)00656-1
875:10.1016/S0002-9149(99)00044-2
142:This group of drugs includes
3499:S-Nitrosocaptopril (SNO-Cap)
3328:Nitroflurbiprofen (HCT-1026)
3323:Nitroatorvastatin (NCX-6560)
2279:Wakefulness-promoting agents
1027:Pentaerythritol tetranitrate
207:Pentaerithrityl tetranitrate
3974:Aminoguanidine (pimagedine)
3867:Aminoguanidine (pimagedine)
3764:Aminoguanidine (pimagedine)
3528:N-Nitroso compounds (e.g.,
3343:Nitropravastatin (NCX-6550)
3254:Isosorbide dinitrate (ISDN)
2721:Effective refractory period
2600:) / End-diastolic dimension
287:acute myocardial infarction
172:Diethylene glycol dinitrate
4413:
4260:AT-II receptor antagonists
4005:Nitroarginine (NNA, NOARG)
3842:1-Amino-2-hydroxyguanidine
3814:Nitroarginine (NNA, NOARG)
3561:Sodium nitroprusside (SNP)
1929:Intravenous immunoglobulin
718:Haberfeld, H, ed. (2007).
403:tricyclic antidepressantss
297:spray (nitro spray) or as
4355:
3006:Tubuloglomerular feedback
2953:Critical closing pressure
2773:Hexaxial reference system
2696:Cardiac electrophysiology
2403:
1370:
1326:Potassium channel openers
1178:
498:). Widening of the large
110:
48:
39:
3739:3-Chloro-5-nitroindazole
3574:Diethylamine/NO (DEA/NO)
3546:Metal nitrosyl complexes
3474:S-Nitrosoalbumin (SNALB)
3168:Cinaciguat (BAY 58-2667)
2981:Renin–angiotensin system
1984:Topoisomerase inhibitors
1668:renin–angiotensin system
1662:Calcium channel blockers
1350:Calcium channel blockers
1268:(arterioles and venules)
749:Anesthesia and Analgesia
541:, and liberation of the
201:potassium channel opener
4331:PDE9 inhibitors (e.g.,
3819:Pentamidine isethionate
3729:3-Bromo-7-nitroindazole
3616:Heterocyclic compounds:
3140:Activators/stimulators:
3011:Cerebral autoregulation
2976:Kinin–kallikrein system
2943:Jugular venous pressure
2593:End-diastolic dimension
2571:Pressure volume diagram
831:10.1124/jpet.105.096115
613:10.1161/01.hyp.35.1.231
4288:L-Type calcium channel
2948:Portal venous pressure
2938:Mean arterial pressure
2852:Ventricular remodeling
2598:End-systolic dimension
2556:Cardiac function curve
1776:Hormonal contraception
1706:Bile acid sequestrants
1487:Proton-pump inhibitors
1450:gastrointestinal tract
1002:Isosorbide mononitrate
800:Sodium nitroprusside:
473:guanosine triphosphate
448:Nitrovasodilators are
424:Nitrates increase the
399:antihypertensive drugs
282:
272:
262:
183:Isosorbide mononitrate
4392:Disulfiram-like drugs
3892:Cindunistat (SD-6010)
3847:2-Ethylaminoguanidine
3604:Spermine/NO (SPER/NO)
3401:O-Nitroso compounds (
2589:Fractional shortening
1286:Hydrazinophthalazines
654:Arzneimittelwirkungen
342:myocardial infarction
311:for the treatment of
293:is used in form of a
278:
268:
257:
4278:receptor antagonists
3951:Ronopterin (VAS-203)
3650:Molsidomine (SIN-10)
3571:(diazeniumdiolates):
3551:Roussin's black salt
3264:Mannitol hexanitrate
2529:End-diastolic volume
2385:Radiopharmaceuticals
2173:Antiparkinson agents
996:Isosorbide dinitrate
411:general anaesthetics
280:Sodium nitroprusside
244:sodium nitroprusside
3645:Linsidomine (SIN-1)
3542:Nitrosyl compounds:
3509:S-Nitrosodiclofenac
3479:S-Nitrosated AR545C
3464:S-Nitroso compounds
2893:Vascular resistance
2731:Electrocardiography
2726:Pacemaker potential
2656:Conduction velocity
2561:Venous return curve
2534:End-systolic volume
2168:Antimigraine agents
2158:Antidementia agents
2061:Anti-inflammatories
1751:Medicated dressings
1691:Antihyperlipidemics
1518:Diabetes medication
684:Medizinische Chemie
515:phosphodiesterase-5
444:Mechanism of action
389:(slow heart rate).
374:(fast heart rate),
313:hypertensive crises
291:glyceryl trinitrate
259:Glyceryl trinitrate
177:Glyceryl trinitrate
3556:Roussin's red salt
3413:Cyclohexyl nitrite
3304:Nipradilol (K-351)
3001:Myogenic mechanism
2619:Left atrial volume
2551:Frank–Starling law
2021:Immunosuppressants
1891:Antimycobacterials
1847:Antithyroid agents
1831:Mineralocorticoids
1635:Cardiac stimulants
1625:Cardiac glycosides
1617:cardiac therapy /
1513:Anti-obesity drugs
1397:Never to phase III
1205:Never to phase III
372:reflex tachycardia
283:
273:
263:
18:Nitric oxide donor
4369:
4368:
4194:
4185:
4168:
4167:
4101:
4079:
4078:
3999:
3995:
3986:
3982:
3979:N-(1-Iminoethyl)-
3945:
3941:
3932:
3928:
3925:N-(1-Iminoethyl)-
3919:
3915:
3912:N-(1-Iminoethyl)-
3852:2-Iminopiperidine
3808:
3804:
3795:
3791:
3782:
3704:
3433:Isopropyl nitrite
3379:Nitroso compounds
3221:
3206:
3205:
3047:
3046:
3043:
3042:
2860:
2859:
2700:Action potential
2691:Conduction system
2637:Cardiac pacemaker
2609:Ejection fraction
2443:
2442:
2346:Ophthalmologicals
2056:Anabolic steroids
1959:Anticancer agents
1922:Ectoparasiticides
1642:Antihypertensives
1590:Antifibrinolytics
1407:
1406:
1253:antihypertensives
1248:Nonsympatholytic
1215:
1214:
982:Nitrovasodilators
729:978-3-85200-181-4
693:978-3-7692-3483-1
663:978-3-8047-1763-3
606:(1 Pt 2): 231–6.
521:Nitrate tolerance
465:guanylate cyclase
436:in patients with
430:dihydroergotamine
385:, sometimes with
334:cardiogenic shock
323:Contraindications
237:active metabolite
131:) by donation of
117:
116:
100:Guanylate cyclase
95:Biological target
63:Class identifiers
16:(Redirected from
4404:
4295:dihydropyridines
4195:-arginine (NOHA)
4192:
4183:
4137:alpha aminoacids
4107:chlorogenic acid
4102:-arginine (NOHA)
4099:
3997:
3993:
3984:
3980:
3943:
3939:
3930:
3926:
3917:
3913:
3806:
3802:
3793:
3789:
3780:
3734:3-Chloroindazole
3717:
3708:
3698:
3396:
3395:
3333:Nitrofluvastatin
3317:
3316:
3259:Itramin tosilate
3215:
3128:
3074:
3067:
3060:
3051:
2986:Vasoconstrictors
2963:Regulation of BP
2876:
2809:pulmonary artery
2782:Chamber pressure
2490:
2470:
2463:
2456:
2447:
2432:
2411:
2410:
2395:Senotherapeutics
2249:Neuroprotectives
2244:Mood stabilizers
2143:Anti-ADHD agents
2083:Muscle relaxants
2016:Immunostimulants
2011:Immunomodulators
1843:Thyroid hormones
1781:Fertility agents
1684:Renin inhibitors
1575:Antihemorrhagics
1542:forming organs (
1528:Dietary minerals
1434:
1427:
1420:
1411:
1266:Nitrovasodilator
1242:
1235:
1228:
1219:
1007:Itramin tosilate
969:cardiac diseases
958:
951:
944:
935:
929:
928:
918:
893:
887:
886:
857:
851:
850:
813:
807:
805:
798:
789:
788:
782:
774:
764:
740:
734:
733:
715:
698:
697:
679:
668:
667:
649:
626:
625:
615:
591:
543:vasoconstrictors
535:oxidative stress
477:protein kinase G
438:coronary disease
301:to be crunched.
261:(nitroglycerine)
192:Itramin tosilate
121:nitrovasodilator
53:
35:Nitrovasodilator
32:
21:
4412:
4411:
4407:
4406:
4405:
4403:
4402:
4401:
4372:
4371:
4370:
4365:
4351:
4315:PDE5 inhibitors
4277:
4241:
4228:
4164:
4141:
4075:
4009:
3960:
3828:
3754:7-Nitroindazole
3749:6-Nitroindazole
3744:5-Nitroindazole
3697:
3689:
3466:(thionitrites):
3394:
3391:
3390:
3389:
3353:Propatylnitrate
3315:
3312:
3311:
3310:
3214:
3202:
3117:
3089:
3078:
3048:
3039:
2957:
2907:
2869:
2866:Vascular system
2856:
2840:
2777:
2679:
2664:(Contractility)
2623:
2575:
2566:Wiggers diagram
2479:
2474:
2444:
2439:
2435:Medicine portal
2399:
2355:
2327:
2322:
2314:Cough medicines
2309:Bronchodilators
2290:
2283:
2163:Antidepressants
2153:Anticonvulsants
2101:
2092:
2088:Bisphosphonates
2078:Corticosteroids
2040:
2027:
1999:
1990:
1974:Spindle poisons
1964:Antimetabolites
1947:
1938:
1860:
1851:
1826:Glucocorticoids
1821:Corticosteroids
1802:
1795:
1762:
1755:
1712:
1630:Antiarrhythmics
1603:
1596:
1553:Antithrombotics
1541:
1532:
1508:Antipropulsives
1504:Antidiarrhoeals
1481:
1452:
1444:
1438:
1408:
1403:
1402:
1387:Clinical trials
1366:
1344:
1320:
1280:
1260:
1246:
1216:
1211:
1210:
1195:Clinical trials
1174:
1063:
1044:
1032:Propatylnitrate
976:
962:
932:
895:
894:
890:
869:(5A): 21C–28C.
859:
858:
854:
815:
814:
810:
799:
792:
775:
742:
741:
737:
730:
717:
716:
701:
694:
681:
680:
671:
664:
651:
650:
629:
593:
592:
588:
584:
567:
558:
523:
508:coronary spasms
458:oxidation state
446:
434:coronary spasms
426:bioavailability
395:
367:
365:Adverse effects
355:PDE5 inhibitors
325:
252:
229:
212:Propatylnitrate
179:(nitroglycerin)
164:
137:angina pectoris
72:Angina pectoris
58:
28:
23:
22:
15:
12:
11:
5:
4410:
4408:
4400:
4399:
4394:
4389:
4384:
4374:
4373:
4367:
4366:
4356:
4353:
4352:
4350:
4349:
4339:
4336:
4329:
4322:
4312:
4302:
4285:
4275:
4271:
4256:ACE inhibitors
4249:
4248:
4243:
4239:
4235:
4230:
4226:
4222:
4217:
4212:
4207:
4198:
4197:
4188:
4176:
4174:
4170:
4169:
4166:
4165:
4163:
4162:
4157:
4151:
4149:
4143:
4142:
4140:
4139:
4134:
4129:
4124:
4119:
4114:
4109:
4104:
4095:
4089:
4087:
4081:
4080:
4077:
4076:
4074:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4017:
4015:
4011:
4010:
4008:
4007:
4002:
3989:
3976:
3970:
3968:
3962:
3961:
3959:
3958:
3953:
3948:
3935:
3922:
3909:
3904:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3838:
3836:
3830:
3829:
3827:
3826:
3821:
3816:
3811:
3798:
3785:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3725:
3723:
3714:
3705:
3691:
3690:
3688:
3687:
3682:
3677:
3672:
3667:
3658:
3657:
3652:
3647:
3642:
3627:
3612:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3564:
3563:
3558:
3553:
3538:
3537:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3459:-Butyl nitrite
3453:
3451:Pentyl nitrite
3448:
3446:-Butyl nitrite
3440:
3438:Methyl nitrite
3435:
3430:
3425:
3420:
3415:
3410:
3403:alkyl nitrites
3392:
3374:
3373:
3368:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3313:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3224:
3222:
3208:
3207:
3204:
3203:
3201:
3200:
3191:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3136:
3134:
3125:
3119:
3118:
3116:
3115:
3110:
3105:
3099:
3097:
3091:
3090:
3079:
3077:
3076:
3069:
3062:
3054:
3045:
3044:
3041:
3040:
3038:
3037:
3036:
3035:
3030:
3025:
3015:
3014:
3013:
3008:
3003:
2996:Autoregulation
2993:
2988:
2983:
2978:
2973:
2967:
2965:
2959:
2958:
2956:
2955:
2950:
2945:
2940:
2935:
2934:
2933:
2928:
2921:Pulse pressure
2917:
2915:
2913:Blood pressure
2909:
2908:
2906:
2905:
2900:
2895:
2890:
2884:
2882:
2873:
2862:
2861:
2858:
2857:
2855:
2854:
2848:
2846:
2842:
2841:
2839:
2838:
2833:
2832:
2831:
2826:
2818:
2817:
2816:
2806:
2805:
2804:
2799:
2791:
2789:Central venous
2785:
2783:
2779:
2778:
2776:
2775:
2770:
2769:
2768:
2763:
2758:
2753:
2748:
2743:
2738:
2728:
2723:
2718:
2717:
2716:
2711:
2706:
2698:
2693:
2687:
2685:
2681:
2680:
2678:
2677:
2671:
2670:(Excitability)
2665:
2659:
2649:
2639:
2633:
2631:
2625:
2624:
2622:
2621:
2616:
2611:
2606:
2601:
2595:
2585:
2583:
2577:
2576:
2574:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2537:
2536:
2531:
2521:
2520:
2519:
2514:
2507:Cardiac output
2504:
2498:
2496:
2494:Cardiac output
2487:
2481:
2480:
2475:
2473:
2472:
2465:
2458:
2450:
2441:
2440:
2438:
2437:
2426:
2421:
2416:
2404:
2401:
2400:
2398:
2397:
2392:
2387:
2382:
2380:Contrast media
2377:
2371:
2369:
2357:
2356:
2354:
2353:
2348:
2342:
2340:
2333:sensory organs
2329:
2328:
2326:
2325:
2320:
2316:
2311:
2306:
2300:
2298:
2285:
2284:
2282:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2232:
2231:
2230:
2225:
2220:
2210:
2205:
2200:
2195:
2190:
2185:
2180:
2178:Antipsychotics
2175:
2170:
2165:
2160:
2155:
2150:
2148:Antiaddictives
2145:
2140:
2135:
2134:
2133:
2128:
2118:
2112:
2110:
2103:nervous system
2094:
2093:
2091:
2090:
2085:
2080:
2075:
2073:Antirheumatics
2070:
2069:
2068:
2058:
2052:
2050:
2029:
2028:
2026:
2025:
2024:
2023:
2018:
2007:
2005:
1992:
1991:
1989:
1988:
1987:
1986:
1981:
1979:Antineoplastic
1976:
1971:
1966:
1955:
1953:
1940:
1939:
1937:
1936:
1931:
1926:
1925:
1924:
1919:
1914:
1912:Antiprotozoals
1907:Antiparasitics
1904:
1899:
1894:
1887:Antibacterials
1883:Antimicrobials
1879:
1877:
1853:
1852:
1850:
1849:
1840:
1835:
1834:
1833:
1828:
1818:
1812:
1810:
1797:
1796:
1794:
1793:
1788:
1783:
1778:
1772:
1770:
1757:
1756:
1754:
1753:
1748:
1746:Antipsoriatics
1743:
1738:
1733:
1727:
1725:
1714:
1713:
1711:
1710:
1709:
1708:
1703:
1698:
1688:
1687:
1686:
1681:
1676:
1674:ACE inhibitors
1664:
1659:
1654:
1649:
1644:
1639:
1638:
1637:
1632:
1627:
1613:
1611:
1602:cardiovascular
1598:
1597:
1595:
1594:
1593:
1592:
1587:
1582:
1572:
1571:
1570:
1565:
1563:Anticoagulants
1560:
1549:
1547:
1534:
1533:
1531:
1530:
1525:
1520:
1515:
1510:
1501:
1496:
1491:
1490:
1489:
1484:
1479:
1475:
1464:
1462:
1446:
1445:
1439:
1437:
1436:
1429:
1422:
1414:
1405:
1404:
1401:
1400:
1399:
1398:
1395:
1384:
1378:
1372:
1371:
1368:
1367:
1365:
1364:
1355:
1353:
1346:
1345:
1343:
1342:
1337:
1331:
1329:
1322:
1321:
1319:
1318:
1313:
1308:
1303:
1298:
1291:
1289:
1282:
1281:
1279:
1278:
1271:
1269:
1262:
1261:
1247:
1245:
1244:
1237:
1230:
1222:
1213:
1212:
1209:
1208:
1207:
1206:
1203:
1192:
1186:
1180:
1179:
1176:
1175:
1173:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1071:
1069:
1065:
1064:
1062:
1061:
1055:
1053:
1046:
1045:
1043:
1042:
1037:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
993:
986:
984:
978:
977:
963:
961:
960:
953:
946:
938:
931:
930:
909:(1): 273–282.
888:
852:
825:(1): 341–354.
808:
790:
755:(1): 152–162.
735:
728:
699:
692:
669:
662:
627:
585:
583:
580:
579:
578:
573:
566:
563:
557:
554:
546:angiotensin II
522:
519:
481:phosphorylates
445:
442:
407:antipsychotics
394:
391:
366:
363:
324:
321:
251:
248:
228:
227:
222:
219:
214:
209:
204:
194:
189:
180:
174:
168:
163:
160:
115:
114:
108:
107:
103:
102:
97:
91:
90:
85:
79:
78:
69:
65:
64:
60:
59:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4409:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4379:
4377:
4364:
4363:
4360:
4354:
4347:
4343:
4340:
4337:
4334:
4330:
4327:
4323:
4320:
4316:
4313:
4310:
4306:
4303:
4300:
4296:
4292:
4289:
4286:
4283:
4279:
4272:
4269:
4265:
4261:
4257:
4254:
4251:
4250:
4247:
4244:
4242:
4236:
4234:
4231:
4229:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4200:
4199:
4196:
4189:
4187:
4181:
4178:
4177:
4175:
4171:
4161:
4158:
4156:
4155:Calmidazolium
4153:
4152:
4150:
4148:
4144:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4096:
4094:
4091:
4090:
4088:
4086:
4082:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4018:
4016:
4012:
4006:
4003:
4001:
3990:
3988:
3977:
3975:
3972:
3971:
3969:
3967:
3963:
3957:
3954:
3952:
3949:
3947:
3936:
3934:
3923:
3921:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3839:
3837:
3835:
3831:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3799:
3797:
3786:
3784:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3726:
3724:
3722:
3718:
3715:
3713:
3709:
3706:
3702:
3696:
3692:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3660:
3659:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3631:
3628:
3626:
3623:
3621:
3617:
3614:
3613:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3566:
3565:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3543:
3540:
3539:
3536:
3533:
3531:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3460:
3458:
3454:
3452:
3449:
3447:
3445:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3423:Hexyl nitrite
3421:
3419:
3418:Ethyl nitrite
3416:
3414:
3411:
3409:
3406:
3404:
3398:
3386:
3384:
3380:
3376:
3375:
3372:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3226:
3225:
3223:
3219:
3213:
3209:
3199:
3196:
3193:
3192:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3138:
3137:
3135:
3133:
3129:
3126:
3124:
3120:
3114:
3111:
3109:
3106:
3104:
3101:
3100:
3098:
3096:
3092:
3088:
3085:
3082:
3075:
3070:
3068:
3063:
3061:
3056:
3055:
3052:
3034:
3031:
3029:
3026:
3024:
3021:
3020:
3019:
3016:
3012:
3009:
3007:
3004:
3002:
2999:
2998:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2968:
2966:
2964:
2960:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2932:
2929:
2927:
2924:
2923:
2922:
2919:
2918:
2916:
2914:
2910:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2885:
2883:
2881:
2877:
2874:
2872:
2867:
2863:
2853:
2850:
2849:
2847:
2843:
2837:
2834:
2830:
2827:
2825:
2822:
2821:
2819:
2815:
2812:
2811:
2810:
2807:
2803:
2800:
2798:
2795:
2794:
2792:
2790:
2787:
2786:
2784:
2780:
2774:
2771:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2734:
2733:
2732:
2729:
2727:
2724:
2722:
2719:
2715:
2712:
2710:
2707:
2705:
2702:
2701:
2699:
2697:
2694:
2692:
2689:
2688:
2686:
2682:
2675:
2672:
2669:
2666:
2663:
2660:
2657:
2653:
2650:
2647:
2643:
2640:
2638:
2635:
2634:
2632:
2630:
2626:
2620:
2617:
2615:
2614:Cardiac index
2612:
2610:
2607:
2605:
2602:
2599:
2596:
2594:
2590:
2587:
2586:
2584:
2582:
2578:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2535:
2532:
2530:
2527:
2526:
2525:
2524:Stroke volume
2522:
2518:
2517:Stroke volume
2515:
2513:
2510:
2509:
2508:
2505:
2503:
2502:Cardiac cycle
2500:
2499:
2497:
2495:
2491:
2488:
2486:
2482:
2478:
2471:
2466:
2464:
2459:
2457:
2452:
2451:
2448:
2436:
2431:
2427:
2425:
2422:
2420:
2417:
2415:
2406:
2405:
2402:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2372:
2370:
2367:
2363:
2358:
2352:
2349:
2347:
2344:
2343:
2341:
2338:
2334:
2330:
2324:
2317:
2315:
2312:
2310:
2307:
2305:
2304:Decongestants
2302:
2301:
2299:
2296:
2292:
2286:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2236:
2233:
2229:
2226:
2224:
2223:Dissociatives
2221:
2219:
2216:
2215:
2214:
2213:Hallucinogens
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2144:
2141:
2139:
2136:
2132:
2129:
2127:
2124:
2123:
2122:
2119:
2117:
2114:
2113:
2111:
2108:
2104:
2099:
2095:
2089:
2086:
2084:
2081:
2079:
2076:
2074:
2071:
2067:
2064:
2063:
2062:
2059:
2057:
2054:
2053:
2051:
2048:
2044:
2038:
2034:
2030:
2022:
2019:
2017:
2014:
2013:
2012:
2009:
2008:
2006:
2003:
1997:
1993:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1961:
1960:
1957:
1956:
1954:
1951:
1945:
1941:
1935:
1932:
1930:
1927:
1923:
1920:
1918:
1917:Anthelmintics
1915:
1913:
1910:
1909:
1908:
1905:
1903:
1900:
1898:
1895:
1892:
1888:
1884:
1881:
1880:
1878:
1875:
1871:
1867:
1863:
1858:
1854:
1848:
1844:
1841:
1839:
1836:
1832:
1829:
1827:
1824:
1823:
1822:
1819:
1817:
1814:
1813:
1811:
1808:
1804:
1798:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1773:
1771:
1768:
1764:
1761:genitourinary
1758:
1752:
1749:
1747:
1744:
1742:
1741:Antipruritics
1739:
1737:
1734:
1732:
1729:
1728:
1726:
1723:
1719:
1715:
1707:
1704:
1702:
1699:
1697:
1694:
1693:
1692:
1689:
1685:
1682:
1680:
1677:
1675:
1672:
1671:
1670:
1669:
1665:
1663:
1660:
1658:
1657:Beta blockers
1655:
1653:
1650:
1648:
1645:
1643:
1640:
1636:
1633:
1631:
1628:
1626:
1623:
1622:
1621:
1620:
1615:
1614:
1612:
1609:
1605:
1599:
1591:
1588:
1586:
1583:
1581:
1578:
1577:
1576:
1573:
1569:
1566:
1564:
1561:
1559:
1558:Antiplatelets
1556:
1555:
1554:
1551:
1550:
1548:
1545:
1539:
1535:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1505:
1502:
1500:
1497:
1495:
1492:
1488:
1485:
1483:
1476:
1474:
1471:
1470:
1469:
1466:
1465:
1463:
1460:
1456:
1451:
1447:
1443:
1435:
1430:
1428:
1423:
1421:
1416:
1415:
1412:
1396:
1394:
1391:
1390:
1388:
1385:
1382:
1379:
1377:
1374:
1373:
1369:
1363:
1362:
1357:
1356:
1354:
1351:
1347:
1341:
1338:
1336:
1333:
1332:
1330:
1327:
1323:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1301:Dihydralazine
1299:
1296:
1293:
1292:
1290:
1287:
1283:
1276:
1275:Nitroprusside
1273:
1272:
1270:
1267:
1263:
1258:
1254:
1251:
1243:
1238:
1236:
1231:
1229:
1224:
1223:
1220:
1204:
1202:
1199:
1198:
1196:
1193:
1190:
1187:
1185:
1182:
1181:
1177:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1072:
1070:
1066:
1060:
1057:
1056:
1054:
1051:
1047:
1041:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
997:
994:
991:
990:Nitroglycerin
988:
987:
985:
983:
979:
974:
970:
966:
959:
954:
952:
947:
945:
940:
939:
936:
926:
922:
917:
912:
908:
904:
900:
892:
889:
884:
880:
876:
872:
868:
864:
856:
853:
848:
844:
840:
836:
832:
828:
824:
820:
812:
809:
804:
797:
795:
791:
786:
780:
772:
768:
763:
758:
754:
750:
746:
739:
736:
731:
725:
721:
720:Austria-Codex
714:
712:
710:
708:
706:
704:
700:
695:
689:
685:
678:
676:
674:
670:
665:
659:
655:
648:
646:
644:
642:
640:
638:
636:
634:
632:
628:
623:
619:
614:
609:
605:
601:
597:
590:
587:
581:
577:
574:
572:
569:
568:
564:
562:
555:
553:
551:
547:
544:
540:
539:peroxynitrite
536:
532:
528:
527:tachyphylaxis
520:
518:
516:
511:
509:
505:
501:
497:
493:
488:
486:
482:
478:
474:
470:
466:
461:
459:
455:
451:
443:
441:
439:
435:
431:
427:
422:
420:
416:
413:, as well as
412:
408:
404:
400:
392:
390:
388:
384:
379:
377:
373:
364:
362:
360:
356:
351:
348:
343:
339:
335:
331:
322:
320:
318:
317:heart failure
314:
310:
309:intravenously
306:
305:Nitroprusside
302:
300:
299:soft capsules
296:
292:
288:
281:
277:
271:
267:
260:
256:
249:
247:
245:
242:, as well as
241:
238:
234:
226:
223:
220:
218:
215:
213:
210:
208:
205:
202:
198:
195:
193:
190:
188:
184:
181:
178:
175:
173:
170:
169:
167:
161:
159:
157:
154:), which are
153:
149:
145:
140:
138:
134:
130:
129:blood vessels
127:(widening of
126:
122:
113:
109:
104:
101:
98:
96:
92:
89:
86:
84:
80:
77:
73:
70:
66:
61:
57:
52:
47:
44:
43:
38:
33:
30:
19:
4397:Vasodilators
4387:Antianginals
4358:
4357:
4333:paraxanthine
4309:beta blocker
4252:
4201:
4179:
3983:-ornithine (
3916:-ornithine (
3661:
3640:Feprosidnine
3635:Sydnonimines
3633:
3618:
3615:
3567:
3544:
3541:
3530:nitrosamines
3527:
3462:
3456:
3443:
3400:
3377:
3227:
3194:
3173:GSK-2181236A
3139:
3081:Nitric oxide
3028:Carotid body
2991:Vasodilators
2871:hemodynamics
2676:(Relaxation)
2668:Bathmotropic
2642:Chronotropic
2218:Psychedelics
2188:Aphrodisiacs
1862:infestations
1838:Sex hormones
1791:Sex hormones
1736:Cicatrizants
1666:
1652:Vasodilators
1619:antianginals
1616:
1468:stomach acid
1467:
1358:
1352:(arterioles)
1328:(arterioles)
1316:Pildralazine
1288:(arterioles)
1265:
1250:vasodilatory
1130:Levosimendan
1075:Benziodarone
1052:vasodilators
981:
965:Vasodilators
906:
902:
891:
866:
862:
855:
822:
818:
811:
779:cite journal
752:
748:
738:
719:
683:
653:
603:
600:Hypertension
599:
589:
559:
524:
512:
489:
471:(cGMP) from
462:
452:that donate
447:
423:
396:
393:Interactions
380:
368:
352:
326:
303:
284:
250:Medical uses
230:
165:
141:
133:nitric oxide
125:vasodilation
120:
118:
106:Legal status
76:vasodilation
56:Nitric oxide
40:
29:
4346:simvastatin
4180:Precursors:
4117:epicatechin
4041:Indospicine
3996:-arginine (
3942:-arginine (
3877:AR-C 102222
3805:-arginine (
3792:-arginine (
3655:Sydnonimine
3388:Nitrite (NO
3371:Trolnitrate
3367:Tenitramine
3309:Nitrate (NO
3195:Inhibitors:
3178:Praliciguat
3158:BAY 60-4552
3153:BAY 41-8543
3148:BAY 41-2272
3033:Glomus cell
3023:Aortic body
3018:Paraganglia
2829:ventricular
2802:ventricular
2751:QT interval
2746:QRS complex
2741:PR interval
2714:ventricular
2652:Dromotropic
2351:Otologicals
2323:antagonists
2289:respiratory
2264:Orexigenics
2259:Neurotoxins
2208:Euphoriants
2198:Entactogens
2193:Depressants
2183:Anxiolytics
2121:Anesthetics
1897:Antifungals
1494:Antiemetics
1482:antagonists
1383:from market
1311:Cadralazine
1306:Endralazine
1295:Hydralazine
1191:from market
1155:Prenylamine
1120:Hexobendine
1080:Carbocromen
1059:Flosequinan
1040:Trolnitrate
1036:Tenitramine
1017:Molsidomine
1012:Linsidomine
387:bradycardia
270:Molsidomine
240:linsidomine
233:molsidomine
225:Trolnitrate
221:Tenitramine
152:nitric acid
112:In Wikidata
4376:Categories
4319:sildenafil
4299:nifedipine
4202:Cofactors:
4191:N-Hydroxy-
4098:N-Hydroxy-
3887:Canavanine
3882:BYK-191023
3701:inhibitors
3630:REC15/2739
3609:V-PYRRO/NO
3299:Nicorandil
3188:Vericiguat
3087:modulators
2971:Baroreflex
2888:Compliance
2880:Blood flow
2756:ST segment
2684:Conduction
2674:Lusitropic
2646:Heart rate
2629:Heart rate
2581:Ultrasound
2512:Heart rate
2274:Stimulants
2254:Nootropics
2228:Deliriants
2203:Entheogens
2138:Anorectics
2116:Analgesics
1969:Alkylating
1902:Antivirals
1857:infections
1731:Emollients
1585:Coagulants
1455:metabolism
1170:Vericiguat
1150:Pimobendan
1145:Oxyfedrine
1140:Nicorandil
1135:Nesiritide
1115:Heptaminol
1110:Gapicomine
1090:Cloridarol
1022:Nicorandil
582:References
550:endothelin
419:sildenafil
361:(Viagra).
359:sildenafil
332:including
295:sublingual
217:Sinitrodil
197:Nicorandil
42:Drug class
4382:Angiology
4359:See also:
4305:Nebivolol
4264:captopril
4186:-Arginine
4127:norvaline
4122:ornithine
4036:GW-273629
3992:N-Methyl-
3938:N-Methyl-
3929:-lysine (
3801:N-Propyl-
3788:N-Methyl-
3769:ARL-17477
3662:Unsorted:
3212:NO donors
3183:Riociguat
3163:BI-703704
3143:Ataciguat
3084:signaling
2931:Diastolic
2903:Perfusion
2662:Inotropic
2541:Afterload
2424:ATC codes
2390:Dressings
2375:Antidotes
2239:Sedatives
2235:Hypnotics
1944:malignant
1801:endocrine
1647:Diuretics
1580:Platelets
1540:and blood
1499:Laxatives
1393:Phase III
1381:Withdrawn
1340:Diazoxide
1335:Minoxidil
1201:Phase III
1189:Withdrawn
1160:Serelaxin
1125:Imolamine
1105:Etafenone
1085:Cinepazet
1050:Quinolone
803:Monograph
504:afterload
347:ischaemia
187:dinitrate
4326:caffeine
4291:blockers
4282:bosentan
4268:losartan
4085:Arginase
4071:VAS-2381
4066:ONO-1714
4014:Unsorted
3774:Indazole
3680:FR146881
3675:FR144220
3665:Cimlanod
3620:Furoxans
3599:PROLI/NO
3569:NONOates
3519:SNO-t-PA
3383:nitrites
3294:NCX-4215
3289:NCX 4040
3284:NCX-4016
3279:NCX-2216
3229:Nitrates
3218:prodrugs
2926:Systolic
2704:cardiac
2269:Serenics
1934:Vaccines
1701:Fibrates
1523:Vitamins
1473:Antacids
1165:Trapidil
1100:Efloxate
967:used in
883:10078539
847:14909302
839:16394199
622:10642303
565:See also
500:arteries
479:, which
450:prodrugs
357:such as
307:is used
235:and its
162:Examples
144:nitrates
83:ATC code
4344:(e.g.,
4342:Statins
4317:(e.g.,
4293:(e.g.,
4280:(e.g.,
4262:(e.g.,
4112:ginseng
4061:NXN-462
4056:NCX-456
4046:KD-7040
4026:CKD-712
3759:A-84643
3625:Furoxan
3524:SNO-vWF
3274:NCX-466
3123:Targets
2546:Preload
2126:General
2033:muscles
2002:L03–L04
1998:disease
1950:L01–L02
1946:disease
1696:Statins
1095:Dilazep
925:9935041
771:7598246
496:preload
485:calcium
415:ethanol
383:syncope
338:anaemia
156:reduced
4173:Others
4132:lysine
3695:Enzyme
3670:FK-409
3584:GLO/NO
3535:SIN-1A
2836:Aortic
2824:atrial
2797:atrial
2793:Right
2766:U wave
2761:T wave
2736:P wave
2709:atrial
2433:
2412:
2360:other
2291:system
2043:joints
1996:immune
1803:system
1763:system
1604:system
1376:WHO-EM
1184:WHO-EM
1068:Others
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769:
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336:, and
148:esters
4205:NADPH
4000:-NMA)
3987:-NIO)
3946:-NMA)
3933:-NIL)
3920:-NIO)
3862:AEITU
3857:1400W
3809:-NPA)
3796:-NMA)
3783:-NIO)
3469:LA810
3095:Forms
2898:Pulse
2845:Other
2820:Left
2814:wedge
2485:Heart
2414:Drugs
2131:Local
2098:brain
2037:bones
1538:blood
843:S2CID
531:thiol
492:veins
376:flush
330:shock
88:C01DA
4220:Heme
4147:CAMK
3966:eNOS
3956:TRIM
3907:MITU
3902:IPTU
3897:EITU
3834:iNOS
3824:TRIM
3721:nNOS
3589:JS-K
3457:tert
2041:and
1718:skin
1361:list
1359:see
973:C01D
921:PMID
879:PMID
835:PMID
785:link
767:PMID
724:ISBN
688:ISBN
658:ISBN
618:PMID
548:and
185:and
4233:CaM
4215:FMN
4210:FAD
4160:W-7
4093:ABH
3872:AMT
3712:NOS
3198:ODQ
3132:sGC
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