2041:
1309:
532:
509:
1298:
51:
42:
6345:
2092:
The nitroprusside reaction is used for the identification of ketones in urine testing. Sodium nitroprusside was found to give a reaction with acetone or creatine under basic conditions in 1882. Rothera refined this method by the use of ammonia in place of sodium or potassium hydroxide. The reaction
1042:
deficiency, anaemia, severe renal disease, or hypovolaemia. Patients with conditions associated with a higher cyanide/thiocyanate ratio (e.g. congenital (Leber's) optic atrophy, tobacco amblyopia) should only be treated with sodium nitroprusside with great caution. Its use in patients with acute
818:
The medication is extremely beneficial for use in medical patients because the effects of the medication will directly stop the second that it stops being infused. This is due to the metabolism of the drug, and the rapid inactivation to thiocyanate once conversion of the drug stops.
1376:
Due to the linear Fe-N-O angle, the relatively short N-O distance of 113 pm and the relatively high stretching frequency of 1947 cm, the complex is formulated as containing an NO ligand. Consequently, iron is assigned an oxidation state of 2+. The iron center has a diamagnetic
1050:
Its use in pregnant women is advised against, although the available evidence suggests it may be safe, provided maternal pH and cyanide levels are closely monitored. Some evidence suggests sodium nitroprusside use in critically ill children may be safe, even without monitoring of
1034:
Sodium nitroprusside should not be used for compensatory hypertension (e.g. due to an arteriovenous stent or coarctation of the aorta). It should not be used in patients with inadequate cerebral circulation or in patients who are near death. It should not be used in patients with
1288:
has been proposed and supported by several clinical findings. These findings may also implicate the potential of drugs that alter NO signalling such as SNP in their treatment. Such a role is also supported by the findings of the recent SNP clinical trial.
2059:, for example, allows local administration of the drug, preventing the systemic effects listed above but still inducing local microvascular vasodilation. Sodium nitroprusside is also used in microbiology, where it has been linked with the dispersal of
2052:. Sodium nitroprusside crystals are also of interest for optical storage. For this application, sodium nitroprusside can be reversibly promoted to a metastable excited state by blue-green light, and de-excited by heat or red light.
4841:
3813:
Fontoura PC, Pinto VL, Matsuura C, Resende Ade C, et al. (October 2012). "Defective Nitric Oxide–Cyclic
Guanosine Monophosphate Signaling in Patients With Bipolar Disorder: A Potential Role for Platelet Dysfunction".
2147:
Sodium nitroprusside is used in a separate urinalysis test known as the cyanide nitroprusside test or Brand's test. In this test, sodium cyanide is added first to urine and let stand for about 10 minutes. In this time,
2948:"Influence of preoperative pulmonary artery pressure on mortality after heart transplantation: testing of potential reversibility of pulmonary hypertension with nitroprusside is useful in defining a high risk group"
4710:
Finocchiaro R, D'Eufemia P, Celli M, Zaccagnini M, et al. (1998). "Usefulness of cyanide-nitroprusside test in detecting incomplete recessive heterozygotes for cystinuria: a standardized dilution procedure".
3903:
Gałecki P, Maes M, Florkowski A, Lewiński A, Gałecka E, Bieńkiewicz M, Szemraj J (March 2011). "Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder".
1645:
2379:
2030:
1043:
congestive heart failure associated with reduced peripheral resistance is also not recommended. Its use in hepatically impaired individuals is also not recommended, as is its use in cases of pre-existing
4834:
1836:
217:
3858:
Bielau H, Brisch R, Bernard-Mittelstaedt J, Dobrowolny H, et al. (June 2012). "Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorder".
5033:
2176:). Cysteine, cystine, homocysteine, and homocystine all react when present in the urine when this test is performed. This test can indicate inborn errors of amino acid transporters such as
3770:
121:
4827:
6390:
2280:
2865:
Sirinek KR, Adcock DK, Levine BA (January 1989). "Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting".
172:
4106:
Navaza A, Chevrier G, Alzari PM, Aymonino PJ (1989). "Single-crystal neutron diffraction structure of sodium pentacyanonitrosylferrate(2-) (sodium nitroprusside) dihydrate".
2782:
2251:
Sodium nitroprusside is primarily used as a vasodilator. It was first used in human medicine in 1928. By 1955, data on its safety during short-term use in people with severe
812:
1261:
light chains are involved in smooth muscle contraction. The result is vascular smooth muscle relaxation, which allow vessels to dilate. This mechanism is similar to that of
601:
3768:
Yanik M, Vural H, Tutkun H, Zoroğlu SS, et al. (February 2004). "The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder".
2686:
2901:
Yusuf S, Collins R, MacMahon S, Peto R (May 1988). "Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials".
4173:
Tritt-Goc J, Piślewski N, Hoffmann SK (1997). "EPR evidence of the paramagnetism of a long-living metastable excited state of a sodium nitroprusside single crystal".
3696:
Bernstein HG, Keilhoff G, Steiner J, Dobrowolny H, et al. (November 2011). "Nitric oxide and schizophrenia: present knowledge and emerging concepts of therapy".
5026:
4313:
3558:
2952:
84:
3207:
2306:
635:
6166:
5019:
1392:
ion to produces the violet colour ion, which is the basis for a sensitive test for S ions. An analogous reaction also exists with OH ions, giving .
4754:
3648:
Silberberg G, Ben-Shachar D, Navon R (October 2010). "Genetic analysis of nitric oxide synthase 1 variants in schizophrenia and bipolar disorder".
4028:"Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: A randomized, double-blind, placebo-controlled trial"
4977:
4694:
4667:
4632:
4490:
4157:
3508:
3370:
2813:
2732:
2659:
2405:
2389:
761:
4210:
Coppens P, Novozhilova I, Kovalevsky A (2002). "Photoinduced
Linkage Isomers of Transition-Metal Nitrosyl Compounds and Related Complexes".
3981:
Savaş HA, Herken H, Yürekli M, Uz E, et al. (2002). "Possible role of nitric oxide and adrenomedullin in bipolar affective disorder".
839:
1100:
is ineffective for removing cyanide from the body but it can be used to remove most of the thiocyanate produced from the above procedure.
2172:
groups. The test will turn a red/purple colour if the test is positive, indicating significant amounts of amino acids were in the urine (
1075:
Due to its cyanogenic nature, overdose may be particularly dangerous. Treatment of sodium nitroprusside overdose includes the following:
1067:
in nature, that is it is possible for other antihypertensive drugs to reduce the threshold for dangerous hypotensive effects to be seen.
5795:
2259:
FDA until 1974 for the treatment of severe hypertension. By 1993, its popularity had grown such that total sales in the US had totalled
2353:
6221:
2831:
1442:
5480:
4962:
4597:
4517:
4249:
2570:
2483:
655:
117:
5646:
2771:
2093:
was now specific for methyl ketones. Addition of ammonium salts (e.g. ammonium sulfate) improved the sensitivity of the test, too.
1851:
5833:
3392:
Zerbe NF, Wagner BK (March 1993). "Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity".
3056:
Palhares DB, Figueiredo CS, Moura AJ (January 1998). "Endotracheal inhalatory sodium nitroprusside in severely hypoxic newborns".
2084:, and thiols. It is also used as a catalyst in the quantitative determination of ammonia in water samples via the phenate method.
5159:
3816:
2527:
808:
4277:
2439:
5450:
2076:
Sodium nitroprusside is also used as an analytical reagent under the name sodium nitroferricyanide for the detection of methyl
1002:
346:
202:
102:
5555:
6235:
4788:
3906:
3017:"Sildenafil vs. sodium before nitroprusside for the pulmonary hypertension reversibility test before cardiac transplantation"
2698:
1250:
745:
2829:
Ikram H, Low CJ, Crozier IG, Shirlaw T (February 1992). "Hemodynamic effects of nitroprusside on valvular aortic stenosis".
4317:
1651:
5917:
5785:
4786:
O'Neala CL, Croucha DJ, Fatahb AA (2000). "Validation of twelve chemical spot tests for the detection of drugs of abuse".
3272:
1352:
1262:
6335:
6375:
6323:
5485:
5309:
3270:
Thomas C, Svehla L, Moffett BS (September 2009). "Sodium nitroprusside induced cyanide toxicity in pediatric patients".
2255:
had become available. Despite this, due to difficulties in its chemical preparation, it was not finally approved by the
804:
448:
6370:
6171:
5982:
5455:
5195:
4994:
2867:
2140:
in proteins. Proteins with the free thiol group give a red colour when added to a solution of sodium nitroprusside in
488:
803:. It is sometimes also used to induce hypotension (to reduce bleeding) for surgical procedures (for which it is also
3199:
2040:
6054:
5940:
5873:
5740:
5319:
3449:
1235:
1388:
The chemical reactions of sodium nitroprusside are mainly associated with the NO ligand. For example, addition of
1245:(NO). It does this by binding to oxyhaemoglobin to release cyanide, methaemoglobin and nitric oxide. NO activates
740:
due to concerns of side effects. High doses are not recommended for more than ten minutes. It works by increasing
6380:
5205:
5093:
4539:
4247:
Reihlen H, von
Friedolsheim A (1927). "Über komplexe Stickoxydverbindungen und das sogenannte einwertige Eisen".
3603:
Bernstein HG, Bogerts B, Keilhoff G (October 2005). "The many faces of nitric oxide in schizophrenia. A review".
3317:
3108:
2614:
2586:
2461:
2193:
2049:
1285:
749:
6012:
5886:
5803:
5445:
2227:. The most common secondary amines encountered in forensic chemistry include 3,4-methylenedioxymethamphetamine (
6365:
4927:
4175:
2256:
1329:
792:
5700:
4432:"Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles"
2055:
In physiology research, sodium nitroprusside is frequently used to test endothelium-independent vasodilation.
760:
Sodium nitroprusside was discovered as early as 1850 and found to be useful in medicine in 1928. It is on the
5992:
5823:
5690:
3200:"Nipride RTU, Nitropress (nitroprusside sodium) dosing, indications, interactions, adverse effects, and more"
6252:
5863:
5780:
5512:
5324:
5200:
4982:
4951:
4385:
4344:
1416:) are related iron nitrosyl complexes. The former was first prepared by treating nitroprusside with sulfur.
1401:
158:
6152:
6059:
5808:
5540:
527:
6249:
5953:
5899:
5762:
5749:
5507:
5210:
4108:
3946:
3605:
2061:
1425:
1308:
1297:
835:
694:
5868:
5470:
5440:
4761:
764:. Sodium nitroprusside is light sensitive, so it needs to be shielded from light to prevent degradation.
477:
6385:
6176:
5858:
5673:
5460:
4819:
4436:
3315:
Rindone JP, Sloane EP (April 1992). "Cyanide toxicity from sodium nitroprusside: Risks and management".
831:
823:
5813:
5517:
5465:
5289:
5284:
1393:
6098:
5695:
5435:
5304:
5294:
5710:
5705:
5535:
5475:
5299:
5225:
5215:
4887:
4445:
4353:
4184:
4117:
3650:
3363:"Nitropress (Nitroprusside Sodium) Drug Information: Clinical Pharmacology – Prescribing Information"
2260:
1378:
1341:
784:
706:
302:
1340:
O. This red-colored sodium salt dissolves in water or ethanol to give solutions containing the free
6186:
6116:
1381:
d electron configuration, although a paramagnetic long-lived metastable state has been observed by
1302:
1012:
843:
827:
777:
773:
504:
363:
5134:
4334:
Woike T, Krasser W, Bechthold PS, Haussühl S (1984). "Extremely Long-Living
Metastable State of Na
3362:
5853:
5838:
5616:
5596:
5565:
5417:
5374:
5139:
5119:
5114:
5109:
5048:
4736:
4008:
3983:
3885:
3840:
3795:
3675:
3630:
3554:"Cyclic Guanosine Monophosphate Signaling and Phosphodiesterase-5 Inhibitors in Cardioprotection"
3417:
3341:
3297:
3081:
2928:
1317:
1113:
1090:
1007:
725:
713:
132:
6121:
5912:
5843:
5591:
5570:
4306:
NBS Misc. Publ. 260-13: Mossbauer
Spectroscopy Standard for the Chemical Shift of Iron Compounds
2205:
2192:, including those in illicit drugs. This compound is thus used as a stain to indicate amines in
5997:
5730:
5124:
5104:
6032:
6027:
5641:
5636:
5560:
5394:
5255:
5250:
5245:
5240:
5084:
4805:
4728:
4690:
4663:
4638:
4628:
4603:
4593:
4566:
4513:
4486:
4463:
4412:
4285:
4229:
4153:
4148:
Housecroft CE, Sharpe AG (2008). "Chapter 22: d-Block metal chemistry: the first row metals".
4085:
4049:
4000:
3963:
3923:
3877:
3832:
3787:
3750:
3713:
3667:
3622:
3585:
3534:
3409:
3333:
3289:
3252:
3178:
3152:
3128:
3073:
3038:
2997:
2970:
2920:
2883:
2847:
2809:
2728:
2655:
2566:
2560:
2541:
2479:
2385:
2113:
1246:
1017:
783:
Nitric oxide reduces both total peripheral resistance and venous return, thus decreasing both
733:
437:
254:
241:
229:
66:
50:
6022:
6017:
6007:
5987:
5720:
5235:
4684:
4657:
4507:
1234:(arterial more than venous), whereas other nitrates exhibit more selectivity for veins (e.g.
6068:
5662:
5631:
5545:
5496:
5389:
5340:
5220:
4867:
4854:
4797:
4720:
4556:
4548:
4453:
4402:
4394:
4361:
4258:
4221:
4212:
4192:
4125:
4077:
4069:
4039:
3992:
3955:
3915:
3869:
3824:
3779:
3742:
3705:
3659:
3614:
3575:
3567:
3524:
3516:
3401:
3325:
3281:
3242:
3168:
3160:
3120:
3065:
3028:
2988:
Knapp E, Gmeiner R (February 1977). "Reduction of pulmonary hypertension by nitroprusside".
2960:
2912:
2903:
2875:
2839:
2647:
2622:
2594:
2531:
2469:
2349:
2224:
2220:
2201:
1433:
1382:
1321:
1281:
1254:
1121:
729:
622:
544:
315:
264:
94:
5818:
5430:
2559:
Nichols DG, Greeley WJ, Lappe DG, Ungerleider RM, Cameron DE, Spevak PJ, Wetzel RC (2006).
457:
372:
6349:
6256:
5927:
5715:
5550:
5314:
3733:
3148:"Ergot intoxication: historical review and description of unusual clinical manifestations"
3103:
3015:
Freitas AF Jr, Bacal F, Oliveira Júnior Jde L, Fiorelli AI, et al. (September 2012).
2236:
2232:
2213:
2144:. Some proteins test positive when denatured, indicating that thiol groups are liberated.
2141:
1064:
887:
872:
531:
508:
292:
282:
272:
3102:
Benitz WE, Malachowski N, Cohen RS, Stevenson DK, Ariagno RL, Sunshine P (January 1985).
2168:. Next, sodium nitroprusside is added to the solution and it reacts with the newly freed
1124:
can be administered to reduce the risk of thiocyanate toxicity induced by nitroprusside.
1120:. In the absence of sufficient thiosulfate, cyanide ions can quickly reach toxic levels.
4449:
4357:
4188:
4121:
41:
6276:
5935:
5828:
5725:
5425:
5412:
5399:
5045:
4988:
4561:
4534:
4407:
4380:
3860:
3580:
3553:
3474:
3173:
3147:
3116:
2651:
2149:
1083:
1044:
800:
796:
690:
4801:
4196:
3529:
3503:
3124:
2916:
6359:
6217:
5966:
5775:
5404:
5384:
5379:
5364:
4902:
4044:
4027:
3679:
3405:
3164:
2965:
2947:
2879:
2843:
2536:
2515:
2431:
2173:
2152:
will be broken by the released cyanide. The destruction of disulfide bonds liberates
2129:
2101:
2056:
1277:
1097:
698:
520:
397:
33:
5011:
4740:
3889:
3844:
3799:
3746:
3634:
3421:
3345:
3247:
3230:
3085:
3033:
3016:
2932:
6294:
6270:
5601:
5369:
5069:
5056:
5042:
4917:
4858:
4851:
4552:
4012:
3873:
3301:
2252:
2209:
2196:. Sodium nitroprusside is similarly used as a presumptive test for the presence of
2161:
1360:
1242:
1223:
1222:
As a result of its breakdown to nitric oxide (NO), sodium nitroprusside has potent
1086:
to convert haemoglobin to methaemoglobin as much as the patient can safely tolerate
741:
185:
180:
2281:"Nitroprusside Rmb, Nitroprusside Sxp, Nitroprusside Tlb (Southern XP IP Pty Ltd)"
2048:
Sodium nitroprusside is often used as a reference compound for the calibration of
1273:(Cialis), which elevate cGMP concentration by inhibiting its degradation by PDE5.
4622:
4304:
3828:
3618:
6307:
6078:
6002:
5611:
5606:
5491:
5332:
5230:
5074:
4912:
4907:
4896:
4365:
2165:
1429:
1364:
1145:
1036:
1022:
997:
878:
165:
3959:
3709:
3571:
3329:
3069:
55:
Molecular structure of this compound (top), and a picture of a sample (bottom).
6280:
6260:
6194:
5848:
5265:
5260:
5149:
5129:
4642:
4129:
3919:
3783:
3285:
2177:
2169:
1266:
1227:
908:
577:
428:
4585:
4262:
4026:
Hallak JE, Maia-de-Oliveira JP, Abrao J, Evora PR, et al. (8 May 2013).
3731:
Coyle JT (July 2013). "Nitric Oxide and
Symptom Reduction in Schizophrenia".
2619:
World Health
Organization model list of essential medicines: 22nd list (2021)
17:
6266:
6225:
6088:
6083:
5144:
4941:
4936:
4381:"Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa"
2240:
2208:, is performed by adding 1 volume of a solution of sodium nitroprusside and
2105:
1270:
1117:
788:
737:
325:
88:
4809:
4607:
4570:
4467:
4416:
4233:
4089:
4053:
4004:
3967:
3927:
3881:
3836:
3791:
3754:
3717:
3671:
3626:
3589:
3293:
3256:
3042:
2591:
World Health
Organization model list of essential medicines: 21st list 2019
6300:
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
4732:
4724:
3538:
3413:
3337:
3182:
3132:
3077:
2974:
2924:
2887:
2851:
2545:
2044:
Sodium nitroprusside spectrum is used to calibrate Mössbauer spectrometers
6287:
6243:
6229:
6144:
6046:
5735:
5626:
5173:
5064:
3663:
3001:
2808:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
2197:
2153:
2137:
2109:
931:
925:
847:
702:
408:
4398:
3438:
2627:
2599:
2180:, which results from pathology in the transport of dibasic amino acids.
799:. In situations where cardiac output is normal, the effect is to reduce
417:
6207:
6073:
5586:
5581:
5530:
5349:
5344:
5270:
5190:
5179:
4458:
4431:
3944:
Dhir A, Kulkarni SK (April 2011). "Nitric oxide and major depression".
2694:
2474:
2217:
2157:
2100:
C(=O)-) under alkaline conditions give bright red coloration (see also
2065:
1842:
1389:
1356:
1052:
612:
383:
4284:. Vol. 2 (2nd ed.). New York: Academic Press. p. 1768.
4225:
4081:
3996:
3520:
6303:
6199:
6093:
5656:
2077:
1258:
1231:
1109:
468:
330:
287:
By haemoglobin being converted to cyanmethaemoglobin and cyanide ions
4590:
Clinical
Methods: The History, Physical, and Laboratory Examinations
3229:
Sass N, Itamoto CH, Silva MP, Torloni MR, et al. (March 2007).
2687:"NITROPRESS (sodium nitroprusside) injection, solution, concentrate"
1249:
in vascular smooth muscle and increases intracellular production of
709:. Onset is nearly immediate and effects last for up to ten minutes.
4485:. American Public Health Association. pp. 4500-NH3 F., 4–114.
4067:
Butler AR, Megson IL (2002). "Non-Heme Iron
Nitrosyls in Biology".
3475:"Nitropress- sodium nitroprusside injection, solution, concentrate"
1424:
Sodium nitroprusside can be synthesized by digesting a solution of
1257:
which activates phosphatases which inactivate myosin light chains.
2189:
2133:
2112:) in urine samples. This reaction is now exploited in the form of
2081:
2039:
1348:
1307:
1301:
Structure of sodium nitroprusside in the solid state, obtained by
1296:
989:
600:
591:
2239:. Sodium nitroprusside is also useful in the identification the
2216:
to a suspected drug, followed by the addition of 2 volumes of an
1640:{\textstyle {\ce {K4 + 6 HNO3 -> H2 + CO2 + NH4NO3 + 4 KNO3}}}
6181:
6108:
5682:
4289:
2228:
1276:
A role for NO in various common psychiatric disorders including
235:
5015:
4823:
4430:
Chua SL, Liu Y, Yam JKH, Tolker-Nielsen T, et al. (2014).
1363:
ligand (Fe-N-O angle = 176.2 °). The anion possesses idealized
248:
111:
4379:
Barraud N, Hassett DJ, Hwang SH, Rice SA, et al. (2006).
3504:"Cyclic Guanosine Monophosphate as a Mediator of Vasodilation"
3104:"Use of sodium nitroprusside in neonates: efficacy and safety"
2990:
International Journal of Clinical Pharmacology and Biopharmacy
2381:
Goodman and Gilman's The Pharmacological Basis of Therapeutics
2025:{\textstyle {\ce {^4- + H2O + NO_2^- -> ^2- + CN- + 2OH-}}}
4624:
Textbook of Biochemistry for Dental/Nursing/Pharmacy Students
4483:
Standard Methods for the Examination of Water and Wastewater
3231:"Does sodium nitroprusside kill babies? A systematic review"
493:
1841:
Alternatively, the nitrosyl ligand can be introduced using
1241:
Sodium nitroprusside breaks down in circulation to release
211:
143:
4760:. École Polytechnique Fédérale de Lausanne. Archived from
3771:
European Archives of Psychiatry and Clinical Neuroscience
2307:"Sodium nitroprusside Baxter (Baxter Healthcare Pty Ltd)"
2096:
In this test, known as Rothera's test, methyl ketones (CH
1964:
1911:
1882:
1821:
1805:
1774:
1746:
1730:
1717:
1694:
1666:
1633:
1613:
1600:
1584:
1553:
1525:
1509:
1485:
1457:
4535:"Note on the sodium nitro-prusside reaction for acetone"
2603:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
224:
762:
World Health Organization's List of Essential Medicines
5065:
Nitroxyl anion (NO; oxonitrate(1-), hyponitrite anion)
3439:"Material Safety Data Sheet Sodium nitroprusside, ACS"
1854:
1831:{\textstyle {\ce {H2 + Na2CO3 -> Na2 + CO2 + H2O}}}
1654:
1445:
795:
where this combination of effects can act to increase
6333:
2565:(2 ed.). Elsevier Health Sciences. p. 192.
2384:(12th ed.). New York: McGraw-Hill Professional.
2352:. The American Society of Health-System Pharmacists.
2104:). Rothera's test was initially applied to detecting
780:. Its effects are usually seen within a few minutes.
695:
blood pressure is very high and resulting in symptoms
2432:"Nitroprusside Pregnancy and Breastfeeding Warnings"
822:
This compound has also been used as a treatment for
663:
InChI=1S/5CN.Fe.NO.2Na/c5*1-2;;1-2;;/q;;;;;2*-1;2*+1
6134:
6107:
6045:
5975:
5926:
5794:
5681:
5672:
5655:
5556:
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
5172:
5092:
5083:
5055:
4950:
4926:
4886:
4866:
2727:(65th ed.). London, UK: Pharmaceutical Press.
621:
611:
589:
576:
543:
538:
519:
487:
467:
447:
427:
407:
382:
362:
337:
324:
314:
301:
291:
281:
271:
263:
201:
196:
171:
157:
131:
101:
83:
75:
65:
60:
2204:) common in illicit substances. The test, called
2024:
1830:
1639:
5370:Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
4627:. India: Jaypee Brothers Publishers. p. 51.
2516:"Sodium nitroprusside: twenty years and counting"
1355:iron(II) centre surrounded by five tightly bound
1108:The cyanide can be detoxified by reaction with a
1079:Discontinuing sodium nitroprusside administration
310:<2 minutes (3 days for thiocyanate metabolite)
4481:Rice EW, Bridgewater L, Easton AD, eds. (2017).
4303:Spijkerman JJ, Snediker DK, Ruegg FC, DeVoe JR.
396:
5231:Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
2464:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
371:
4314:National Institute of Standards and Technology
2562:Critical Heart Disease in Infants and Children
2243:(thiol groups) in the nitroprusside reaction.
116:
6391:World Health Organization essential medicines
5647:N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
5206:Ethylene glycol dinitrate (EGDN; nitroglycol)
5027:
4835:
4506:Kaneko JJ, Harvey JW, Bruss ML, eds. (2008).
3698:CNS & Neurological Disorders Drug Targets
3559:Journal of the American College of Cardiology
8:
4512:(6th ed.). Academic Press. p. 98.
4143:
4141:
4139:
2946:Costard-Jäckle A, Fowler MB (January 1992).
2781:. Hospira Australia Pty Ltd. 22 April 2010.
2772:"DBL® SODIUM NITROPRUSSIDE FOR INJECTION BP"
2188:Sodium nitroprusside is also used to detect
840:respiratory distress syndrome in the newborn
689:among others, is a medication used to lower
32:
4282:Handbook of Preparative Inorganic Chemistry
2514:Friederich JA, Butterworth JF (July 1995).
1312:Space filling model of sodium nitroprusside
5678:
5669:
5089:
5034:
5020:
5012:
4842:
4828:
4820:
4588:. In Walker HK, Hall WD, Hurst JW (eds.).
3552:Kukreja RC, Salloum FN, Das A (May 2012).
2509:
2507:
2505:
2503:
2501:
2499:
2497:
2495:
2468:. World Health Organization. p. 283.
2344:
2342:
2340:
2338:
2336:
2334:
2332:
2330:
2328:
530:
507:
436:
5390:Isobutyl nitrite (2-methylpropyl nitrite)
5300:Nitroglycerin (glyceryl trinitrate (GTN))
4560:
4509:Clinical Biochemistry of Domestic Animals
4457:
4406:
4101:
4099:
4043:
3579:
3528:
3497:
3495:
3246:
3172:
3032:
2964:
2626:
2598:
2535:
2473:
2378:Brunton L, Chabner B, Knollman B (2010).
2015:
2010:
1998:
1982:
1967:
1963:
1958:
1947:
1939:
1929:
1924:
1910:
1905:
1889:
1881:
1876:
1865:
1857:
1855:
1853:
1820:
1815:
1804:
1799:
1777:
1773:
1768:
1757:
1749:
1745:
1740:
1729:
1724:
1716:
1711:
1693:
1688:
1677:
1669:
1665:
1660:
1655:
1653:
1632:
1627:
1622:
1612:
1607:
1599:
1594:
1583:
1578:
1556:
1552:
1547:
1536:
1528:
1524:
1519:
1508:
1503:
1498:
1484:
1479:
1468:
1460:
1456:
1451:
1446:
1444:
860:Adverse effects by incidence and severity
736:. It is not generally recommended during
456:
3691:
3689:
2223:solution. The test turns blue for some
1126:
6340:
5466:S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
5456:S-Nitroso-N-valerylpenicillamine (SNVP)
3433:
3431:
3146:Merhoff GC, Porter JM (November 1974).
2766:
2764:
2272:
660:
640:
503:
416:
354:Sodium pentacyanidonitrosylferrate(III)
351:
5451:S-Nitroso-N-acetylpenicillamine (SNAP)
5325:Sodium trioxodinitrate (Angeli's salt)
4592:(3rd ed.). Boston: Butterworths.
4152:(3rd ed.). Pearson. p. 721.
3939:
3937:
3455:from the original on 24 September 2015
3357:
3355:
3194:
3192:
2785:from the original on 10 September 2017
2762:
2760:
2758:
2756:
2754:
2752:
2750:
2748:
2746:
2744:
2718:
2716:
2311:Therapeutic Goods Administration (TGA)
2285:Therapeutic Goods Administration (TGA)
1093:to convert the cyanide to thiocyanate.
521:
31:
27:Medication for lowering blood pressure
4689:. New Age International. p. 64.
3097:
3095:
2681:
2679:
2677:
2675:
2673:
2671:
2621:. Geneva: World Health Organization.
2593:. Geneva: World Health Organization.
2442:from the original on 21 December 2016
2356:from the original on 21 December 2016
2231:, the main component in ecstasy) and
1263:phosphodiesterase 5 (PDE5) inhibitors
1063:The only known drug interactions are
744:levels in the blood, which increases
732:. Other serious side effects include
476:
93:
7:
6286:non-selective PDE inhibitors (e.g.,
5070:Nitric oxide (NO; nitrogen monoxide)
3210:from the original on 3 December 2013
2373:
2371:
184:
5310:Pentaerithrityl tetranitrate (PETN)
5196:Diethylene glycol dinitrate (DEGDN)
4662:. Academic Publishers. p. 56.
3448:. Berlin Packaging. 1 August 2006.
3021:Arquivos Brasileiros de Cardiologia
2068:by acting as a nitric oxide donor.
387:
6215:Indirect/downstream NO modulators:
5983:Asymmetric dimethylarginine (ADMA)
4323:from the original on 4 March 2016.
3373:from the original on 21 April 2014
2723:Joint Formulary Committee (2013).
2652:10.1016/B978-0-323-03961-1.X5001-6
1432:, followed by neutralization with
25:
6013:Nitroarginine methyl ester (NAME)
5476:S-Nitrosoglutathione (GSNO, SNOG)
5446:S-Nitroso-N-acetylcysteine (SNAC)
5320:Propylene glycol dinitrate (PGDN)
5075:Nitrosonium (NO; nitrosyl cation)
4250:Justus Liebigs Annalen der Chemie
2528:Lippincott Williams & Wilkins
2410:U.S. Food and Drug Administration
701:, and during surgery to decrease
6343:
4621:Chatterjea MN (1 January 2004).
4045:10.1001/jamapsychiatry.2013.1292
3406:10.1097/00003246-199303000-00027
3165:10.1097/00000658-197411000-00011
2725:British National Formulary (BNF)
2537:10.1213/00000539-199507000-00031
1155:(mg/kg) for skin administration
707:continuous injection into a vein
558:
49:
40:
5541:Diethylenetriamine/NO (DETA/NO)
4713:Journal of Urology and Research
4584:Comstock JP, Garber AJ (1990).
3747:10.1001/jamapsychiatry.2013.210
3248:10.1590/S1516-31802007000200008
3034:10.1590/S0066-782X2012005000076
2132:used to detect the presence of
1137:(mg/kg) for oral administration
1082:Buffering the cyanide by using
1003:Increased intracranial pressure
791:. So, it can be used in severe
668:Key:FPWUWQVZUNFZQM-UHFFFAOYSA-N
5741:N-(1-Iminoethyl)-L-ornithine (
4789:Forensic Science International
4553:10.1113/jphysiol.1908.sp001285
4278:"Sodium Nitrosyl Cyanoferrate"
3907:Journal of Affective Disorders
3874:10.1016/j.brainres.2012.04.022
2697:. January 2011. Archived from
2406:"First Generic Drug Approvals"
1978:
1974:
1968:
1954:
1948:
1940:
1935:
1885:
1872:
1866:
1858:
1788:
1784:
1778:
1764:
1758:
1750:
1733:
1700:
1684:
1678:
1670:
1567:
1563:
1557:
1543:
1537:
1529:
1512:
1488:
1475:
1469:
1461:
570:
564:
549:
1:
6324:Receptor/signaling modulators
5993:Guanidinoethyldisulfide (GED)
5211:Isosorbide mononitrate (ISMN)
5201:Erythritol tetranitrate (ETN)
4802:10.1016/S0379-0738(99)00235-2
4686:Question Bank of Biochemistry
4342:O Single Crystals: Optical".
4197:10.1016/S0009-2614(97)00217-0
3273:Expert Opinion on Drug Safety
3125:10.1016/S0022-3476(85)80477-7
3058:Journal of Perinatal Medicine
2917:10.1016/S0140-6736(88)91906-X
2806:Australian Medicines Handbook
1328:, usually encountered as the
685:), sold under the brand name
5461:S-Nitrosocaptopril (SNO-Cap)
5290:Nitroflurbiprofen (HCT-1026)
5285:Nitroatorvastatin (NCX-6560)
4755:"TLC Visualization Reagents"
3829:10.1097/PSY.0b013e3182689460
3619:10.1016/j.schres.2005.05.019
2966:10.1016/0735-1097(92)90050-W
2880:10.1016/0002-9610(89)90416-9
2844:10.1016/0002-9149(92)90234-P
994:Reduced platelet aggregation
756:History, society and culture
748:levels in cells, and causes
724:Common side effects include
643:..O=N(C#N)(C#N)(C#N)(C#N)C#N
555:
5936:Aminoguanidine (pimagedine)
5829:Aminoguanidine (pimagedine)
5726:Aminoguanidine (pimagedine)
5490:N-Nitroso compounds (e.g.,
5305:Nitropravastatin (NCX-6550)
5216:Isosorbide dinitrate (ISDN)
4610:– via NCBI Bookshelf.
4366:10.1103/PhysRevLett.53.1767
3369:. RxList Inc. 4 July 2009.
2646:. Mosby. pp. 761–774.
1347:Nitroprusside is a complex
627:100 mg/mL (20 °C)
71:Nipride, Nitropress, others
6407:
6222:AT-II receptor antagonists
5967:Nitroarginine (NNA, NOARG)
5804:1-Amino-2-hydroxyguanidine
5776:Nitroarginine (NNA, NOARG)
5523:Sodium nitroprusside (SNP)
3960:10.1016/j.niox.2011.02.002
3710:10.2174/187152711798072392
3572:10.1016/j.jacc.2011.09.086
3330:10.1177/106002809202600413
3070:10.1515/jpme.1998.26.3.219
2644:Comprehensive Hypertension
2631:. WHO/MHP/HPS/EML/2021.02.
1116:, catalysed by the enzyme
776:infused in cases of acute
720:Side effects and mechanism
693:. This may be done if the
539:Chemical and physical data
6317:
4972:
4928:Potassium channel openers
4130:10.1107/S0108270188013691
3920:10.1016/j.jad.2010.09.005
3784:10.1007/s00406-004-0453-x
3286:10.1517/14740330903081717
3235:Sao Paulo Medical Journal
2615:World Health Organization
2587:World Health Organization
2462:World Health Organization
2194:thin layer chromatography
1286:major depressive disorder
750:dilation of blood vessels
651:
631:
342:
48:
39:
5701:3-Chloro-5-nitroindazole
5536:Diethylamine/NO (DEA/NO)
5508:Metal nitrosyl complexes
5436:S-Nitrosoalbumin (SNALB)
5130:Cinaciguat (BAY 58-2667)
4952:Calcium channel blockers
4870:(arterioles and venules)
4586:"Chapter 140. Ketonuria"
4263:10.1002/jlac.19274570103
4176:Chemical Physics Letters
2520:Anesthesia and Analgesia
2466:WHO Model Formulary 2008
1293:Structure and properties
978:Injection site streaking
793:congestive heart failure
772:Sodium nitroprusside is
6293:PDE9 inhibitors (e.g.,
5781:Pentamidine isethionate
5691:3-Bromo-7-nitroindazole
5578:Heterocyclic compounds:
5102:Activators/stimulators:
4386:Journal of Bacteriology
4345:Physical Review Letters
2050:Mössbauer spectrometers
1359:ligands and one linear
975:Injection site erythema
963:Orthostatic hypotension
6250:L-Type calcium channel
4276:Brauer G, ed. (1963).
3606:Schizophrenia Research
3394:Critical Care Medicine
2779:TGA eBusiness Services
2350:"Sodium Nitroprusside"
2126:nitroprusside reaction
2062:Pseudomonas aeruginosa
2045:
2026:
1832:
1641:
1426:potassium ferrocyanide
1313:
1305:
836:pulmonary hypertension
697:, in certain types of
333:(100%; as thiocyanate)
5854:Cindunistat (SD-6010)
5809:2-Ethylaminoguanidine
5566:Spermine/NO (SPER/NO)
5363:O-Nitroso compounds (
4888:Hydrazinophthalazines
4725:10.1007/s002400050076
4437:Nature Communications
3502:Murad F (July 1986).
2953:J. Am. Coll. Cardiol.
2804:Rossi S, ed. (2013).
2043:
2027:
1833:
1642:
1311:
1300:
832:myocardial infarction
824:aortic valve stenosis
712:It is available as a
189:) QC02DD01 (vet)
6240:receptor antagonists
5913:Ronopterin (VAS-203)
5612:Molsidomine (SIN-10)
5533:(diazeniumdiolates):
5513:Roussin's black salt
5226:Mannitol hexanitrate
3664:10.1002/ajmg.b.31112
3651:Am. J. Med. Genet. B
1852:
1652:
1443:
1402:Roussin's black salt
1316:Nitroprusside is an
957:Paraesthesial warmth
881:(low blood pressure)
679:Sodium nitroprusside
34:Sodium nitroprusside
6376:Iron(III) compounds
5607:Linsidomine (SIN-1)
5504:Nitrosyl compounds:
5471:S-Nitrosodiclofenac
5441:S-Nitrosated AR545C
5426:S-Nitroso compounds
4540:J. Physiol. (Lond.)
4533:Rothera AC (1908).
4450:2014NatCo...5.4462C
4399:10.1128/JB.00779-06
4358:1984PhRvL..53.1767W
4189:1997CPL...268..471T
4150:Inorganic Chemistry
4122:1989AcCrC..45..839N
4109:Acta Crystallogr. C
3479:labeling.pfizer.com
2120:Thiols and cysteine
2116:(e.g. "Ketostix").
1966:
1934:
1913:
1884:
1823:
1807:
1776:
1748:
1732:
1719:
1696:
1668:
1635:
1615:
1602:
1586:
1555:
1527:
1511:
1487:
1459:
1303:neutron diffraction
1218:Mechanism of action
1013:Methaemoglobinaemia
919:Thyroid suppression
828:oesophageal varices
778:hypertensive crises
623:Solubility in water
244:(Prescription only)
220:(Prescription only)
36:
6371:Nitrosyl complexes
5518:Roussin's red salt
5375:Cyclohexyl nitrite
5266:Nipradilol (K-351)
4999:Never to phase III
4459:10.1038/ncomms5462
3984:Neuropsychobiology
3509:J. Clin. Investig.
3318:Ann. Pharmacother.
3204:Medscape Reference
2701:on 3 December 2013
2200:(amine-containing
2072:Analytical reagent
2046:
2022:
1946:
1920:
1901:
1864:
1828:
1811:
1795:
1756:
1736:
1720:
1707:
1676:
1656:
1637:
1623:
1603:
1590:
1574:
1535:
1515:
1499:
1467:
1447:
1394:Roussin's red salt
1318:inorganic compound
1314:
1306:
1091:sodium thiosulfate
1008:Metabolic acidosis
726:low blood pressure
714:generic medication
316:Duration of action
277:100% (intravenous)
6331:
6330:
6156:
6147:
6130:
6129:
6063:
6041:
6040:
5961:
5957:
5948:
5944:
5941:N-(1-Iminoethyl)-
5907:
5903:
5894:
5890:
5887:N-(1-Iminoethyl)-
5881:
5877:
5874:N-(1-Iminoethyl)-
5814:2-Iminopiperidine
5770:
5766:
5757:
5753:
5744:
5666:
5395:Isopropyl nitrite
5341:Nitroso compounds
5183:
5168:
5167:
5009:
5008:
4855:antihypertensives
4850:Nonsympatholytic
4696:978-81-224-1736-4
4683:Joshi RA (2006).
4669:978-93-80599-17-5
4634:978-81-8061-204-6
4492:978-0-87553-287-5
4352:(18): 1767–1770.
4226:10.1021/cr000031c
4159:978-0-13-175553-6
4082:10.1021/cr000076d
3997:10.1159/000048677
3566:(22): 1921–1927.
3521:10.1172/JCI112536
2911:(8594): 1088–92.
2815:978-0-9805790-9-3
2734:978-0-85711-084-8
2661:978-0-323-03961-1
2412:. 17 October 2022
2391:978-0-07-162442-8
2287:. 5 December 2022
2114:urine test strips
2014:
1997:
1973:
1953:
1945:
1923:
1916:
1904:
1871:
1863:
1826:
1814:
1798:
1783:
1763:
1755:
1739:
1723:
1710:
1699:
1683:
1675:
1659:
1626:
1606:
1593:
1577:
1562:
1542:
1534:
1518:
1502:
1474:
1466:
1450:
1351:that features an
1253:. cGMP activates
1247:guanylate cyclase
1215:
1214:
1030:Contraindications
1018:Cyanide poisoning
939:Unknown frequency
890:(high heart rate)
734:methemoglobinemia
676:
675:
602:Interactive image
489:CompTox Dashboard
252:
239:
227:
215:
147:
114:
16:(Redirected from
6398:
6381:Sodium compounds
6348:
6347:
6346:
6339:
6257:dihydropyridines
6157:-arginine (NOHA)
6154:
6145:
6099:alpha aminoacids
6069:chlorogenic acid
6064:-arginine (NOHA)
6061:
5959:
5955:
5946:
5942:
5905:
5901:
5892:
5888:
5879:
5875:
5768:
5764:
5755:
5751:
5742:
5696:3-Chloroindazole
5679:
5670:
5660:
5358:
5357:
5295:Nitrofluvastatin
5279:
5278:
5221:Itramin tosilate
5177:
5090:
5036:
5029:
5022:
5013:
4868:Nitrovasodilator
4844:
4837:
4830:
4821:
4814:
4813:
4783:
4777:
4776:
4774:
4772:
4766:
4759:
4751:
4745:
4744:
4707:
4701:
4700:
4680:
4674:
4673:
4653:
4647:
4646:
4618:
4612:
4611:
4581:
4575:
4574:
4564:
4547:(5–6): 491–494.
4530:
4524:
4523:
4503:
4497:
4496:
4478:
4472:
4471:
4461:
4427:
4421:
4420:
4410:
4376:
4370:
4369:
4331:
4325:
4324:
4322:
4311:
4300:
4294:
4293:
4273:
4267:
4266:
4244:
4238:
4237:
4213:Chemical Reviews
4207:
4201:
4200:
4183:(5–6): 471–474.
4170:
4164:
4163:
4145:
4134:
4133:
4103:
4094:
4093:
4076:(4): 1155–1165.
4064:
4058:
4057:
4047:
4023:
4017:
4016:
3978:
3972:
3971:
3941:
3932:
3931:
3900:
3894:
3893:
3855:
3849:
3848:
3810:
3804:
3803:
3765:
3759:
3758:
3728:
3722:
3721:
3693:
3684:
3683:
3658:(7): 1318–1328.
3645:
3639:
3638:
3600:
3594:
3593:
3583:
3549:
3543:
3542:
3532:
3499:
3490:
3489:
3487:
3485:
3471:
3465:
3464:
3462:
3460:
3454:
3443:
3435:
3426:
3425:
3389:
3383:
3382:
3380:
3378:
3359:
3350:
3349:
3312:
3306:
3305:
3267:
3261:
3260:
3250:
3226:
3220:
3219:
3217:
3215:
3196:
3187:
3186:
3176:
3143:
3137:
3136:
3099:
3090:
3089:
3053:
3047:
3046:
3036:
3012:
3006:
3005:
2985:
2979:
2978:
2968:
2943:
2937:
2936:
2898:
2892:
2891:
2862:
2856:
2855:
2826:
2820:
2819:
2801:
2795:
2794:
2792:
2790:
2776:
2768:
2739:
2738:
2720:
2711:
2710:
2708:
2706:
2683:
2666:
2665:
2639:
2633:
2632:
2630:
2611:
2605:
2604:
2602:
2583:
2577:
2576:
2556:
2550:
2549:
2539:
2511:
2490:
2489:
2477:
2458:
2452:
2451:
2449:
2447:
2428:
2422:
2421:
2419:
2417:
2402:
2396:
2395:
2375:
2366:
2365:
2363:
2361:
2346:
2323:
2322:
2320:
2318:
2303:
2297:
2296:
2294:
2292:
2277:
2225:secondary amines
2221:sodium carbonate
2202:natural products
2031:
2029:
2028:
2023:
2021:
2020:
2019:
2012:
2003:
2002:
1995:
1990:
1989:
1981:
1977:
1971:
1965:
1962:
1957:
1951:
1943:
1933:
1928:
1921:
1914:
1912:
1909:
1902:
1897:
1896:
1888:
1883:
1880:
1875:
1869:
1861:
1837:
1835:
1834:
1829:
1827:
1824:
1822:
1819:
1812:
1806:
1803:
1796:
1791:
1787:
1781:
1775:
1772:
1767:
1761:
1753:
1747:
1744:
1737:
1731:
1728:
1721:
1718:
1715:
1708:
1703:
1697:
1695:
1692:
1687:
1681:
1673:
1667:
1664:
1657:
1646:
1644:
1643:
1638:
1636:
1634:
1631:
1624:
1614:
1611:
1604:
1601:
1598:
1591:
1585:
1582:
1575:
1570:
1566:
1560:
1554:
1551:
1546:
1540:
1532:
1526:
1523:
1516:
1510:
1507:
1500:
1491:
1486:
1483:
1478:
1472:
1464:
1458:
1455:
1448:
1434:sodium carbonate
1383:EPR spectroscopy
1322:chemical formula
1282:bipolar disorder
1255:protein kinase G
1127:
1122:Hydroxocobalamin
954:Chest discomfort
875:(low heart rate)
730:cyanide toxicity
705:. It is used by
604:
584:
572:
566:
560:
557:
551:
534:
523:
512:
511:
497:
495:
480:
460:
440:
420:
400:
390:
389:
375:
306:
297:nearly immediate
250:
247:
237:
234:
226:
223:
213:
210:
188:
145:
142:
124:
113:
110:
97:
53:
44:
37:
35:
21:
6406:
6405:
6401:
6400:
6399:
6397:
6396:
6395:
6366:Cyano complexes
6356:
6355:
6354:
6344:
6342:
6334:
6332:
6327:
6313:
6277:PDE5 inhibitors
6239:
6203:
6190:
6126:
6103:
6037:
5971:
5922:
5790:
5716:7-Nitroindazole
5711:6-Nitroindazole
5706:5-Nitroindazole
5659:
5651:
5428:(thionitrites):
5356:
5353:
5352:
5351:
5315:Propatylnitrate
5277:
5274:
5273:
5272:
5176:
5164:
5079:
5051:
5040:
5010:
5005:
5004:
4989:Clinical trials
4968:
4946:
4922:
4882:
4862:
4848:
4818:
4817:
4785:
4784:
4780:
4770:
4768:
4764:
4757:
4753:
4752:
4748:
4709:
4708:
4704:
4697:
4682:
4681:
4677:
4670:
4655:
4654:
4650:
4635:
4620:
4619:
4615:
4600:
4583:
4582:
4578:
4532:
4531:
4527:
4520:
4505:
4504:
4500:
4493:
4480:
4479:
4475:
4429:
4428:
4424:
4393:(21): 7344–53.
4378:
4377:
4373:
4341:
4337:
4333:
4332:
4328:
4320:
4309:
4302:
4301:
4297:
4275:
4274:
4270:
4246:
4245:
4241:
4209:
4208:
4204:
4172:
4171:
4167:
4160:
4147:
4146:
4137:
4105:
4104:
4097:
4066:
4065:
4061:
4032:JAMA Psychiatry
4025:
4024:
4020:
3980:
3979:
3975:
3943:
3942:
3935:
3914:(1–3): 175–82.
3902:
3901:
3897:
3857:
3856:
3852:
3817:Psychosom. Med.
3812:
3811:
3807:
3767:
3766:
3762:
3734:JAMA Psychiatry
3730:
3729:
3725:
3695:
3694:
3687:
3647:
3646:
3642:
3602:
3601:
3597:
3551:
3550:
3546:
3501:
3500:
3493:
3483:
3481:
3473:
3472:
3468:
3458:
3456:
3452:
3441:
3437:
3436:
3429:
3391:
3390:
3386:
3376:
3374:
3361:
3360:
3353:
3314:
3313:
3309:
3269:
3268:
3264:
3228:
3227:
3223:
3213:
3211:
3198:
3197:
3190:
3145:
3144:
3140:
3101:
3100:
3093:
3055:
3054:
3050:
3014:
3013:
3009:
2987:
2986:
2982:
2945:
2944:
2940:
2900:
2899:
2895:
2864:
2863:
2859:
2832:Am. J. Cardiol.
2828:
2827:
2823:
2816:
2803:
2802:
2798:
2788:
2786:
2774:
2770:
2769:
2742:
2735:
2722:
2721:
2714:
2704:
2702:
2685:
2684:
2669:
2662:
2641:
2640:
2636:
2613:
2612:
2608:
2585:
2584:
2580:
2573:
2558:
2557:
2553:
2513:
2512:
2493:
2486:
2460:
2459:
2455:
2445:
2443:
2430:
2429:
2425:
2415:
2413:
2404:
2403:
2399:
2392:
2377:
2376:
2369:
2359:
2357:
2348:
2347:
2326:
2316:
2314:
2305:
2304:
2300:
2290:
2288:
2279:
2278:
2274:
2269:
2249:
2237:methamphetamine
2233:phenethylamines
2214:deionized water
2186:
2150:disulfide bonds
2142:aqueous ammonia
2122:
2099:
2090:
2074:
2038:
2011:
1994:
1938:
1856:
1850:
1849:
1650:
1649:
1441:
1440:
1422:
1415:
1411:
1407:
1399:
1370:
1339:
1335:
1327:
1295:
1220:
1154:
1143:
1136:
1112:-donor such as
1106:
1073:
1065:pharmacodynamic
1061:
1040:
1032:
981:
969:Skin irritation
936:
888:Tachyarrhythmia
873:Bradyarrhythmia
861:
856:
854:Adverse effects
770:
758:
722:
672:
669:
664:
659:
658:
647:
644:
639:
638:
607:
582:
569:
563:
554:
515:
491:
483:
463:
443:
423:
403:
386:
378:
358:
355:
350:
349:
320:1 to 10 minutes
304:
293:Onset of action
273:Bioavailability
265:Pharmacokinetic
259:
192:
160:
153:
134:
127:
56:
28:
23:
22:
15:
12:
11:
5:
6404:
6402:
6394:
6393:
6388:
6383:
6378:
6373:
6368:
6358:
6357:
6353:
6352:
6329:
6328:
6318:
6315:
6314:
6312:
6311:
6301:
6298:
6291:
6284:
6274:
6264:
6247:
6237:
6233:
6218:ACE inhibitors
6211:
6210:
6205:
6201:
6197:
6192:
6188:
6184:
6179:
6174:
6169:
6160:
6159:
6150:
6138:
6136:
6132:
6131:
6128:
6127:
6125:
6124:
6119:
6113:
6111:
6105:
6104:
6102:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6066:
6057:
6051:
6049:
6043:
6042:
6039:
6038:
6036:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5995:
5990:
5985:
5979:
5977:
5973:
5972:
5970:
5969:
5964:
5951:
5938:
5932:
5930:
5924:
5923:
5921:
5920:
5915:
5910:
5897:
5884:
5871:
5866:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5826:
5821:
5816:
5811:
5806:
5800:
5798:
5792:
5791:
5789:
5788:
5783:
5778:
5773:
5760:
5747:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5698:
5693:
5687:
5685:
5676:
5667:
5653:
5652:
5650:
5649:
5644:
5639:
5634:
5629:
5620:
5619:
5614:
5609:
5604:
5589:
5574:
5573:
5568:
5563:
5558:
5553:
5548:
5543:
5538:
5526:
5525:
5520:
5515:
5500:
5499:
5483:
5478:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5421:-Butyl nitrite
5415:
5413:Pentyl nitrite
5410:
5408:-Butyl nitrite
5402:
5400:Methyl nitrite
5397:
5392:
5387:
5382:
5377:
5372:
5365:alkyl nitrites
5354:
5336:
5335:
5330:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5275:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5186:
5184:
5170:
5169:
5166:
5165:
5163:
5162:
5153:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5098:
5096:
5087:
5081:
5080:
5078:
5077:
5072:
5067:
5061:
5059:
5053:
5052:
5041:
5039:
5038:
5031:
5024:
5016:
5007:
5006:
5003:
5002:
5001:
5000:
4997:
4986:
4980:
4974:
4973:
4970:
4969:
4967:
4966:
4957:
4955:
4948:
4947:
4945:
4944:
4939:
4933:
4931:
4924:
4923:
4921:
4920:
4915:
4910:
4905:
4900:
4893:
4891:
4884:
4883:
4881:
4880:
4873:
4871:
4864:
4863:
4849:
4847:
4846:
4839:
4832:
4824:
4816:
4815:
4796:(3): 189–201.
4778:
4767:on 13 May 2015
4746:
4702:
4695:
4675:
4668:
4656:Das D (1980).
4648:
4633:
4613:
4598:
4576:
4525:
4518:
4498:
4491:
4473:
4422:
4371:
4339:
4335:
4326:
4295:
4268:
4239:
4220:(4): 861–883.
4202:
4165:
4158:
4135:
4116:(6): 839–841.
4095:
4059:
4018:
3973:
3954:(3): 125–131.
3933:
3895:
3861:Brain Research
3850:
3823:(8): 873–877.
3805:
3760:
3741:(7): 664–665.
3723:
3704:(7): 792–807.
3685:
3640:
3595:
3544:
3491:
3466:
3427:
3400:(3): 465–467.
3384:
3351:
3324:(4): 515–519.
3307:
3280:(5): 599–602.
3262:
3241:(2): 108–111.
3221:
3188:
3159:(5): 773–779.
3138:
3117:Elsevier Mosby
3091:
3064:(3): 219–224.
3048:
3007:
2980:
2938:
2893:
2857:
2838:(4): 361–366.
2821:
2814:
2796:
2740:
2733:
2712:
2667:
2660:
2642:Lip G (2007).
2634:
2606:
2578:
2571:
2551:
2491:
2484:
2453:
2423:
2397:
2390:
2367:
2324:
2298:
2271:
2270:
2268:
2265:
2248:
2245:
2185:
2182:
2121:
2118:
2108:(a symptom of
2097:
2089:
2086:
2073:
2070:
2037:
2034:
2033:
2032:
2018:
2009:
2006:
2001:
1993:
1988:
1985:
1980:
1976:
1970:
1961:
1956:
1950:
1942:
1937:
1932:
1927:
1919:
1908:
1900:
1895:
1892:
1887:
1879:
1874:
1868:
1860:
1839:
1838:
1818:
1810:
1802:
1794:
1790:
1786:
1780:
1771:
1766:
1760:
1752:
1743:
1735:
1727:
1714:
1706:
1702:
1691:
1686:
1680:
1672:
1663:
1647:
1630:
1621:
1618:
1610:
1597:
1589:
1581:
1573:
1569:
1565:
1559:
1550:
1545:
1539:
1531:
1522:
1514:
1506:
1497:
1494:
1490:
1482:
1477:
1471:
1463:
1454:
1428:in water with
1421:
1418:
1413:
1409:
1405:
1397:
1368:
1337:
1333:
1325:
1294:
1291:
1219:
1216:
1213:
1212:
1209:
1206:
1203:
1199:
1198:
1195:
1192:
1189:
1185:
1184:
1181:
1178:
1175:
1171:
1170:
1167:
1164:
1161:
1157:
1156:
1152:
1149:
1148:administration
1141:
1138:
1134:
1131:
1105:
1102:
1095:
1094:
1087:
1084:sodium nitrite
1080:
1072:
1069:
1060:
1057:
1045:hypothyroidism
1038:
1031:
1028:
1027:
1026:
1020:
1015:
1010:
1005:
1000:
995:
992:
980:
979:
976:
973:
970:
967:
964:
961:
960:Abdominal pain
958:
955:
952:
949:
946:
942:
935:
934:
928:
923:
920:
917:
914:
911:
906:
903:
900:
897:
894:
891:
885:
882:
876:
869:
859:
855:
852:
848:ergot toxicity
801:blood pressure
797:cardiac output
769:
766:
757:
754:
721:
718:
691:blood pressure
674:
673:
671:
670:
667:
665:
662:
654:
653:
652:
649:
648:
646:
645:
642:
634:
633:
632:
629:
628:
625:
619:
618:
617:1.72 g/cm
615:
609:
608:
606:
605:
597:
595:
587:
586:
580:
574:
573:
567:
561:
552:
547:
541:
540:
536:
535:
525:
517:
516:
514:
513:
500:
498:
485:
484:
482:
481:
473:
471:
465:
464:
462:
461:
453:
451:
445:
444:
442:
441:
433:
431:
425:
424:
422:
421:
413:
411:
405:
404:
402:
401:
393:
391:
380:
379:
377:
376:
368:
366:
360:
359:
357:
356:
353:
345:
344:
343:
340:
339:
335:
334:
328:
322:
321:
318:
312:
311:
308:
299:
298:
295:
289:
288:
285:
279:
278:
275:
269:
268:
261:
260:
258:
257:
245:
232:
221:
207:
205:
199:
198:
194:
193:
191:
190:
177:
175:
169:
168:
163:
161:administration
155:
154:
152:
151:
149:
139:
137:
129:
128:
126:
125:
107:
105:
99:
98:
91:
81:
80:
77:
73:
72:
69:
63:
62:
58:
57:
54:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6403:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6372:
6369:
6367:
6364:
6363:
6361:
6351:
6341:
6337:
6326:
6325:
6322:
6316:
6309:
6305:
6302:
6299:
6296:
6292:
6289:
6285:
6282:
6278:
6275:
6272:
6268:
6265:
6262:
6258:
6254:
6251:
6248:
6245:
6241:
6234:
6231:
6227:
6223:
6219:
6216:
6213:
6212:
6209:
6206:
6204:
6198:
6196:
6193:
6191:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6162:
6161:
6158:
6151:
6149:
6143:
6140:
6139:
6137:
6133:
6123:
6120:
6118:
6117:Calmidazolium
6115:
6114:
6112:
6110:
6106:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6058:
6056:
6053:
6052:
6050:
6048:
6044:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5980:
5978:
5974:
5968:
5965:
5963:
5952:
5950:
5939:
5937:
5934:
5933:
5931:
5929:
5925:
5919:
5916:
5914:
5911:
5909:
5898:
5896:
5885:
5883:
5872:
5870:
5867:
5865:
5862:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5801:
5799:
5797:
5793:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5761:
5759:
5748:
5746:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5688:
5686:
5684:
5680:
5677:
5675:
5671:
5668:
5664:
5658:
5654:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5622:
5621:
5618:
5615:
5613:
5610:
5608:
5605:
5603:
5600:
5598:
5593:
5590:
5588:
5585:
5583:
5579:
5576:
5575:
5572:
5569:
5567:
5564:
5562:
5559:
5557:
5554:
5552:
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5528:
5527:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5505:
5502:
5501:
5498:
5495:
5493:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5422:
5420:
5416:
5414:
5411:
5409:
5407:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5385:Hexyl nitrite
5383:
5381:
5380:Ethyl nitrite
5378:
5376:
5373:
5371:
5368:
5366:
5360:
5348:
5346:
5342:
5338:
5337:
5334:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5188:
5187:
5185:
5181:
5175:
5171:
5161:
5158:
5155:
5154:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5100:
5099:
5097:
5095:
5091:
5088:
5086:
5082:
5076:
5073:
5071:
5068:
5066:
5063:
5062:
5060:
5058:
5054:
5050:
5047:
5044:
5037:
5032:
5030:
5025:
5023:
5018:
5017:
5014:
4998:
4996:
4993:
4992:
4990:
4987:
4984:
4981:
4979:
4976:
4975:
4971:
4965:
4964:
4959:
4958:
4956:
4953:
4949:
4943:
4940:
4938:
4935:
4934:
4932:
4929:
4925:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4903:Dihydralazine
4901:
4898:
4895:
4894:
4892:
4889:
4885:
4878:
4877:Nitroprusside
4875:
4874:
4872:
4869:
4865:
4860:
4856:
4853:
4845:
4840:
4838:
4833:
4831:
4826:
4825:
4822:
4811:
4807:
4803:
4799:
4795:
4791:
4790:
4782:
4779:
4763:
4756:
4750:
4747:
4742:
4738:
4734:
4730:
4726:
4722:
4718:
4714:
4706:
4703:
4698:
4692:
4688:
4687:
4679:
4676:
4671:
4665:
4661:
4660:
4652:
4649:
4644:
4640:
4636:
4630:
4626:
4625:
4617:
4614:
4609:
4605:
4601:
4599:9780409900774
4595:
4591:
4587:
4580:
4577:
4572:
4568:
4563:
4558:
4554:
4550:
4546:
4542:
4541:
4536:
4529:
4526:
4521:
4519:9780080568829
4515:
4511:
4510:
4502:
4499:
4494:
4488:
4484:
4477:
4474:
4469:
4465:
4460:
4455:
4451:
4447:
4443:
4439:
4438:
4433:
4426:
4423:
4418:
4414:
4409:
4404:
4400:
4396:
4392:
4388:
4387:
4382:
4375:
4372:
4367:
4363:
4359:
4355:
4351:
4347:
4346:
4330:
4327:
4319:
4315:
4308:
4307:
4299:
4296:
4291:
4287:
4283:
4279:
4272:
4269:
4264:
4260:
4256:
4252:
4251:
4243:
4240:
4235:
4231:
4227:
4223:
4219:
4215:
4214:
4206:
4203:
4198:
4194:
4190:
4186:
4182:
4178:
4177:
4169:
4166:
4161:
4155:
4151:
4144:
4142:
4140:
4136:
4131:
4127:
4123:
4119:
4115:
4111:
4110:
4102:
4100:
4096:
4091:
4087:
4083:
4079:
4075:
4072:
4071:
4063:
4060:
4055:
4051:
4046:
4041:
4037:
4033:
4029:
4022:
4019:
4014:
4010:
4006:
4002:
3998:
3994:
3990:
3986:
3985:
3977:
3974:
3969:
3965:
3961:
3957:
3953:
3949:
3948:
3940:
3938:
3934:
3929:
3925:
3921:
3917:
3913:
3909:
3908:
3899:
3896:
3891:
3887:
3883:
3879:
3875:
3871:
3867:
3863:
3862:
3854:
3851:
3846:
3842:
3838:
3834:
3830:
3826:
3822:
3819:
3818:
3809:
3806:
3801:
3797:
3793:
3789:
3785:
3781:
3777:
3773:
3772:
3764:
3761:
3756:
3752:
3748:
3744:
3740:
3736:
3735:
3727:
3724:
3719:
3715:
3711:
3707:
3703:
3699:
3692:
3690:
3686:
3681:
3677:
3673:
3669:
3665:
3661:
3657:
3653:
3652:
3644:
3641:
3636:
3632:
3628:
3624:
3620:
3616:
3612:
3608:
3607:
3599:
3596:
3591:
3587:
3582:
3577:
3573:
3569:
3565:
3561:
3560:
3555:
3548:
3545:
3540:
3536:
3531:
3526:
3522:
3518:
3514:
3511:
3510:
3505:
3498:
3496:
3492:
3480:
3476:
3470:
3467:
3451:
3447:
3440:
3434:
3432:
3428:
3423:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3388:
3385:
3372:
3368:
3364:
3358:
3356:
3352:
3347:
3343:
3339:
3335:
3331:
3327:
3323:
3320:
3319:
3311:
3308:
3303:
3299:
3295:
3291:
3287:
3283:
3279:
3275:
3274:
3266:
3263:
3258:
3254:
3249:
3244:
3240:
3236:
3232:
3225:
3222:
3209:
3205:
3201:
3195:
3193:
3189:
3184:
3180:
3175:
3170:
3166:
3162:
3158:
3155:
3154:
3149:
3142:
3139:
3134:
3130:
3126:
3122:
3118:
3114:
3111:
3110:
3105:
3098:
3096:
3092:
3087:
3083:
3079:
3075:
3071:
3067:
3063:
3059:
3052:
3049:
3044:
3040:
3035:
3030:
3027:(3): 848–56.
3026:
3022:
3018:
3011:
3008:
3003:
2999:
2995:
2991:
2984:
2981:
2976:
2972:
2967:
2962:
2958:
2955:
2954:
2949:
2942:
2939:
2934:
2930:
2926:
2922:
2918:
2914:
2910:
2906:
2905:
2897:
2894:
2889:
2885:
2881:
2877:
2873:
2870:
2869:
2861:
2858:
2853:
2849:
2845:
2841:
2837:
2834:
2833:
2825:
2822:
2817:
2811:
2807:
2800:
2797:
2784:
2780:
2773:
2767:
2765:
2763:
2761:
2759:
2757:
2755:
2753:
2751:
2749:
2747:
2745:
2741:
2736:
2730:
2726:
2719:
2717:
2713:
2700:
2696:
2692:
2688:
2682:
2680:
2678:
2676:
2674:
2672:
2668:
2663:
2657:
2653:
2649:
2645:
2638:
2635:
2629:
2624:
2620:
2616:
2610:
2607:
2601:
2596:
2592:
2588:
2582:
2579:
2574:
2572:9780323070072
2568:
2564:
2563:
2555:
2552:
2547:
2543:
2538:
2533:
2529:
2525:
2521:
2517:
2510:
2508:
2506:
2504:
2502:
2500:
2498:
2496:
2492:
2487:
2485:9789241547659
2481:
2476:
2471:
2467:
2463:
2457:
2454:
2441:
2437:
2433:
2427:
2424:
2411:
2407:
2401:
2398:
2393:
2387:
2383:
2382:
2374:
2372:
2368:
2355:
2351:
2345:
2343:
2341:
2339:
2337:
2335:
2333:
2331:
2329:
2325:
2313:. 2 June 2023
2312:
2308:
2302:
2299:
2286:
2282:
2276:
2273:
2266:
2264:
2262:
2258:
2254:
2246:
2244:
2242:
2238:
2234:
2230:
2226:
2222:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2183:
2181:
2179:
2175:
2174:aminoaciduria
2171:
2167:
2163:
2159:
2155:
2151:
2145:
2143:
2139:
2135:
2131:
2130:chemical test
2127:
2119:
2117:
2115:
2111:
2107:
2103:
2102:iodoform test
2094:
2087:
2085:
2083:
2079:
2071:
2069:
2067:
2064:
2063:
2058:
2057:Iontophoresis
2053:
2051:
2042:
2035:
2016:
2007:
2004:
1999:
1991:
1986:
1983:
1959:
1930:
1925:
1917:
1906:
1898:
1893:
1890:
1877:
1848:
1847:
1846:
1844:
1816:
1808:
1800:
1792:
1769:
1741:
1725:
1712:
1704:
1689:
1661:
1648:
1628:
1619:
1616:
1608:
1595:
1587:
1579:
1571:
1548:
1520:
1504:
1495:
1492:
1480:
1452:
1439:
1438:
1437:
1435:
1431:
1427:
1419:
1417:
1403:
1395:
1391:
1386:
1384:
1380:
1374:
1372:
1367:
1362:
1358:
1354:
1350:
1345:
1343:
1331:
1323:
1319:
1310:
1304:
1299:
1292:
1290:
1287:
1283:
1279:
1278:schizophrenia
1274:
1272:
1269:(Viagra) and
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1239:
1237:
1236:nitroglycerin
1233:
1229:
1225:
1217:
1210:
1207:
1204:
1201:
1200:
1196:
1193:
1190:
1187:
1186:
1182:
1179:
1176:
1173:
1172:
1168:
1165:
1162:
1159:
1158:
1150:
1147:
1139:
1132:
1129:
1128:
1125:
1123:
1119:
1115:
1111:
1103:
1101:
1099:
1098:Haemodialysis
1092:
1088:
1085:
1081:
1078:
1077:
1076:
1070:
1068:
1066:
1058:
1056:
1054:
1048:
1046:
1041:
1029:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
993:
991:
988:
987:
986:
985:
977:
974:
971:
968:
965:
962:
959:
956:
953:
950:
947:
944:
943:
941:
940:
933:
929:
927:
924:
922:Muscle twitch
921:
918:
915:
912:
910:
907:
904:
901:
898:
895:
892:
889:
886:
883:
880:
877:
874:
871:
870:
868:
867:
863:
862:
853:
851:
849:
845:
841:
837:
833:
829:
825:
820:
816:
814:
810:
806:
802:
798:
794:
790:
786:
781:
779:
775:
774:intravenously
767:
765:
763:
755:
753:
751:
747:
743:
739:
735:
731:
727:
719:
717:
715:
710:
708:
704:
700:
699:heart failure
696:
692:
688:
684:
680:
666:
661:
657:
650:
641:
637:
630:
626:
624:
620:
616:
614:
610:
603:
599:
598:
596:
593:
588:
581:
579:
575:
548:
546:
542:
537:
533:
529:
526:
524:
522:ECHA InfoCard
518:
510:
506:
505:DTXSID7041126
502:
501:
499:
490:
486:
479:
475:
474:
472:
470:
466:
459:
455:
454:
452:
450:
446:
439:
435:
434:
432:
430:
426:
419:
415:
414:
412:
410:
406:
399:
395:
394:
392:
385:
381:
374:
370:
369:
367:
365:
361:
352:
348:
341:
336:
332:
329:
327:
323:
319:
317:
313:
309:
307:
300:
296:
294:
290:
286:
284:
280:
276:
274:
270:
266:
262:
256:
246:
243:
233:
231:
222:
219:
209:
208:
206:
204:
200:
195:
187:
182:
179:
178:
176:
174:
170:
167:
164:
162:
156:
150:
141:
140:
138:
136:
130:
123:
122:Nitroprusside
119:
109:
108:
106:
104:
100:
96:
92:
90:
86:
82:
78:
74:
70:
68:
64:
61:Clinical data
59:
52:
47:
43:
38:
30:
19:
18:Nitroprusside
6386:Vasodilators
6320:
6319:
6295:paraxanthine
6271:beta blocker
6214:
6163:
6141:
5945:-ornithine (
5878:-ornithine (
5623:
5602:Feprosidnine
5597:Sydnonimines
5595:
5580:
5577:
5529:
5522:
5506:
5503:
5492:nitrosamines
5489:
5424:
5418:
5405:
5362:
5339:
5189:
5156:
5135:GSK-2181236A
5101:
5043:Nitric oxide
4960:
4954:(arterioles)
4930:(arterioles)
4918:Pildralazine
4890:(arterioles)
4876:
4852:vasodilatory
4793:
4787:
4781:
4769:. Retrieved
4762:the original
4749:
4719:(6): 401–5.
4716:
4712:
4705:
4685:
4678:
4659:Biochemistry
4658:
4651:
4623:
4616:
4589:
4579:
4544:
4538:
4528:
4508:
4501:
4482:
4476:
4441:
4435:
4425:
4390:
4384:
4374:
4349:
4343:
4329:
4305:
4298:
4281:
4271:
4254:
4248:
4242:
4217:
4211:
4205:
4180:
4174:
4168:
4149:
4113:
4107:
4073:
4068:
4062:
4038:(7): E3–E5.
4035:
4031:
4021:
3991:(2): 57–61.
3988:
3982:
3976:
3951:
3947:Nitric Oxide
3945:
3911:
3905:
3898:
3865:
3859:
3853:
3820:
3815:
3808:
3778:(1): 43–47.
3775:
3769:
3763:
3738:
3732:
3726:
3701:
3697:
3655:
3649:
3643:
3613:(1): 69–86.
3610:
3604:
3598:
3563:
3557:
3547:
3512:
3507:
3482:. Retrieved
3478:
3469:
3457:. Retrieved
3445:
3397:
3393:
3387:
3375:. Retrieved
3366:
3321:
3316:
3310:
3277:
3271:
3265:
3238:
3234:
3224:
3212:. Retrieved
3203:
3156:
3151:
3141:
3112:
3107:
3061:
3057:
3051:
3024:
3020:
3010:
2996:(2): 75–80.
2993:
2989:
2983:
2959:(1): 48–54.
2956:
2951:
2941:
2908:
2902:
2896:
2874:(1): 33–37.
2871:
2868:Am. J. Surg.
2866:
2860:
2835:
2830:
2824:
2805:
2799:
2787:. Retrieved
2778:
2724:
2703:. Retrieved
2699:the original
2690:
2643:
2637:
2628:10665/345533
2618:
2609:
2600:10665/325771
2590:
2581:
2561:
2554:
2523:
2519:
2465:
2456:
2444:. Retrieved
2435:
2426:
2414:. Retrieved
2409:
2400:
2380:
2358:. Retrieved
2317:10 September
2315:. Retrieved
2310:
2301:
2289:. Retrieved
2284:
2275:
2253:hypertension
2250:
2210:acetaldehyde
2206:Simon's test
2187:
2162:homocysteine
2146:
2125:
2123:
2095:
2091:
2075:
2060:
2054:
2047:
1840:
1423:
1387:
1375:
1365:
1361:nitric oxide
1346:
1315:
1275:
1243:nitric oxide
1240:
1224:vasodilating
1221:
1144:(mg/kg) for
1107:
1096:
1074:
1062:
1059:Interactions
1049:
1033:
983:
982:
938:
937:
896:Restlessness
893:Apprehension
884:Palpitations
865:
864:
858:
857:
821:
817:
782:
771:
759:
742:nitric oxide
723:
711:
686:
682:
678:
677:
478:ChEMBL136478
303:Elimination
203:Legal status
197:Legal status
103:License data
29:
6308:simvastatin
6142:Precursors:
6079:epicatechin
6003:Indospicine
5958:-arginine (
5904:-arginine (
5839:AR-C 102222
5767:-arginine (
5754:-arginine (
5617:Sydnonimine
5350:Nitrite (NO
5333:Trolnitrate
5329:Tenitramine
5271:Nitrate (NO
5157:Inhibitors:
5140:Praliciguat
5120:BAY 60-4552
5115:BAY 41-8543
5110:BAY 41-2272
4985:from market
4913:Cadralazine
4908:Endralazine
4897:Hydralazine
4771:21 November
3459:21 November
3377:21 November
3214:20 November
3119:: 102–110.
3109:J. Pediatr.
2789:20 November
2705:20 November
2530:: 152–162.
2475:10665/44053
2446:14 December
2416:28 November
2263:2 million.
2166:homocystine
2160:as well as
1430:nitric acid
1420:Preparation
1226:effects on
1114:thiosulfate
1023:Thiocyanate
998:Haemorrhage
966:ECG changes
879:Hypotension
815:labelled).
768:Medical use
585: g·mol
528:100.119.126
338:Identifiers
166:Intravenous
76:Other names
67:Trade names
6360:Categories
6281:sildenafil
6261:nifedipine
6164:Cofactors:
6153:N-Hydroxy-
6060:N-Hydroxy-
5849:Canavanine
5844:BYK-191023
5663:inhibitors
5592:REC15/2739
5571:V-PYRRO/NO
5261:Nicorandil
5150:Vericiguat
5049:modulators
4643:1027921456
4070:Chem. Rev.
3515:(1): 1–5.
3153:Ann. Surg.
2360:8 December
2267:References
2241:mercaptans
2178:cystinuria
2170:sulfhydryl
2136:groups of
2036:Other uses
1353:octahedral
1344:dianion .
1267:sildenafil
1228:arterioles
1104:Toxicology
909:Somnolence
687:Nitropress
590:3D model (
578:Molar mass
458:EAO03PE1TC
429:ChemSpider
373:13755-38-9
364:CAS Number
347:IUPAC name
283:Metabolism
6321:See also:
6267:Nebivolol
6226:captopril
6148:-Arginine
6089:norvaline
6084:ornithine
5998:GW-273629
5954:N-Methyl-
5900:N-Methyl-
5891:-lysine (
5763:N-Propyl-
5750:N-Methyl-
5731:ARL-17477
5624:Unsorted:
5174:NO donors
5145:Riociguat
5125:BI-703704
5105:Ataciguat
5046:signaling
4995:Phase III
4983:Withdrawn
4942:Diazoxide
4937:Minoxidil
4257:: 71–82.
3868:: 91–99.
3680:205325558
3206:. WebMD.
2436:Drugs.com
2198:alkaloids
2106:ketonuria
2017:−
2000:−
1987:−
1936:⟶
1931:−
1894:−
1734:⟶
1513:⟶
1330:dihydrate
1320:with the
1271:tadalafil
1183:>2000
1118:rhodanese
1089:Infusing
1037:vitamin B
902:Dizziness
899:Confusion
789:afterload
738:pregnancy
326:Excretion
305:half-life
159:Routes of
133:Pregnancy
95:Monograph
89:Drugs.com
6350:Medicine
6288:caffeine
6253:blockers
6244:bosentan
6230:losartan
6047:Arginase
6033:VAS-2381
6028:ONO-1714
5976:Unsorted
5736:Indazole
5642:FR146881
5637:FR144220
5627:Cimlanod
5582:Furoxans
5561:PROLI/NO
5531:NONOates
5481:SNO-t-PA
5345:nitrites
5256:NCX-4215
5251:NCX 4040
5246:NCX-4016
5241:NCX-2216
5191:Nitrates
5180:prodrugs
4810:10725655
4741:28323457
4608:21250091
4571:16992945
4468:25042103
4444:: 4462.
4417:17050922
4338:·2H
4318:Archived
4290:63014307
4234:11942781
4090:11942790
4054:23699763
4005:11893860
3968:21335097
3928:20888049
3890:25790297
3882:22560594
3845:37347633
3837:23023680
3800:24592011
3792:14991378
3755:23699799
3718:21999729
3672:20645313
3635:42764954
3627:16005189
3590:22624832
3484:1 August
3450:Archived
3422:43866386
3371:Archived
3346:35273460
3294:19645589
3257:17625709
3208:Archived
3086:31630912
3043:22898992
2933:27098017
2783:Archived
2691:DailyMed
2617:(2021).
2589:(2019).
2440:Archived
2438:. 2018.
2354:Archived
2235:such as
2154:cysteine
2138:cysteine
2110:diabetes
2066:biofilms
1379:low-spin
1371:symmetry
1265:such as
1071:Overdose
1025:toxicity
972:Flushing
948:Retching
932:azotemia
926:Oliguria
916:Sweating
905:Headache
703:bleeding
438:21170789
409:DrugBank
398:11953895
173:ATC code
135:category
6306:(e.g.,
6304:Statins
6279:(e.g.,
6255:(e.g.,
6242:(e.g.,
6224:(e.g.,
6074:ginseng
6023:NXN-462
6018:NCX-456
6008:KD-7040
5988:CKD-712
5721:A-84643
5587:Furoxan
5486:SNO-vWF
5236:NCX-466
5085:Targets
4733:9879820
4562:1533603
4446:Bibcode
4408:1636254
4354:Bibcode
4185:Bibcode
4118:Bibcode
4013:7505572
3581:4230443
3539:2873150
3414:8440119
3338:1533553
3302:5334690
3183:4371616
3174:1343691
3133:3917495
3078:9773383
2975:1729345
2925:2896919
2888:2491934
2852:1734649
2695:Hospira
2546:7598246
2291:9 April
2247:History
2218:aqueous
2158:cystine
2088:Ketones
2078:ketones
1843:nitrite
1357:cyanide
1342:complex
1232:venules
1130:Species
1055:level.
1053:cyanide
984:Serious
951:Anxiety
785:preload
613:Density
583:261.921
545:Formula
418:DB00325
384:PubChem
228::
183: (
181:C02DD01
148: C
120::
6336:Portal
6135:Others
6094:lysine
5657:Enzyme
5632:FK-409
5546:GLO/NO
5497:SIN-1A
4978:WHO-EM
4808:
4739:
4731:
4693:
4666:
4641:
4631:
4606:
4596:
4569:
4559:
4516:
4489:
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4288:
4232:
4156:
4088:
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3880:
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3835:
3798:
3790:
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3670:
3633:
3625:
3588:
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3537:
3530:329522
3527:
3446:Qorpak
3420:
3412:
3367:RxList
3344:
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3292:
3255:
3181:
3171:
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3000:
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2904:Lancet
2886:
2850:
2812:
2731:
2658:
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2482:
2388:
2190:amines
2184:Amines
2082:amines
1400:) and
1259:Myosin
1188:Rabbit
1110:sulfur
945:Nausea
930:Renal
866:Common
846:, and
811:, and
636:SMILES
469:ChEMBL
331:kidney
255:℞-only
253:
240:
230:℞-only
216:
115:
6167:NADPH
5962:-NMA)
5949:-NIO)
5908:-NMA)
5895:-NIL)
5882:-NIO)
5824:AEITU
5819:1400W
5771:-NPA)
5758:-NMA)
5745:-NIO)
5431:LA810
5057:Forms
4765:(PDF)
4758:(PDF)
4737:S2CID
4321:(PDF)
4310:(PDF)
4009:S2CID
3886:S2CID
3841:S2CID
3796:S2CID
3676:S2CID
3631:S2CID
3453:(PDF)
3442:(PDF)
3418:S2CID
3342:S2CID
3298:S2CID
3115:(1).
3082:S2CID
2929:S2CID
2775:(PDF)
2526:(1).
2164:from
2156:from
2134:thiol
2128:is a
1404:(NaFe
1349:anion
1160:Mouse
990:Ileus
844:shock
656:InChI
592:JSmol
6182:Heme
6109:CAMK
5928:eNOS
5918:TRIM
5869:MITU
5864:IPTU
5859:EITU
5796:iNOS
5786:TRIM
5683:nNOS
5551:JS-K
5419:tert
4963:list
4961:see
4806:PMID
4773:2013
4729:PMID
4691:ISBN
4664:ISBN
4639:OCLC
4629:ISBN
4604:PMID
4594:ISBN
4567:PMID
4514:ISBN
4487:ISBN
4464:PMID
4413:PMID
4286:LCCN
4230:PMID
4154:ISBN
4086:PMID
4050:PMID
4001:PMID
3964:PMID
3924:PMID
3878:PMID
3866:1459
3833:PMID
3788:PMID
3751:PMID
3714:PMID
3668:PMID
3656:153B
3623:PMID
3586:PMID
3535:PMID
3486:2019
3461:2013
3410:PMID
3379:2013
3334:PMID
3290:PMID
3253:PMID
3216:2013
3179:PMID
3129:PMID
3074:PMID
3039:PMID
2998:PMID
2971:PMID
2921:PMID
2884:PMID
2848:PMID
2810:ISBN
2791:2013
2729:ISBN
2707:2013
2656:ISBN
2567:ISBN
2542:PMID
2480:ISBN
2448:2016
2418:2022
2386:ISBN
2362:2016
2319:2023
2293:2023
2261:US$
2229:MDMA
2124:The
1412:(NO)
1332:, Na
1284:and
1251:cGMP
1230:and
1180:11.2
913:Rash
813:MHRA
787:and
746:cGMP
728:and
449:UNII
267:data
85:AHFS
6195:CaM
6177:FMN
6172:FAD
6122:W-7
6055:ABH
5834:AMT
5674:NOS
5160:ODQ
5094:sGC
4859:C02
4798:doi
4794:109
4721:doi
4557:PMC
4549:doi
4454:doi
4403:PMC
4395:doi
4391:188
4362:doi
4259:doi
4255:457
4222:doi
4218:102
4193:doi
4181:268
4126:doi
4078:doi
4074:102
4040:doi
3993:doi
3956:doi
3916:doi
3912:129
3870:doi
3825:doi
3780:doi
3776:254
3743:doi
3706:doi
3660:doi
3615:doi
3576:PMC
3568:doi
3525:PMC
3517:doi
3402:doi
3326:doi
3282:doi
3243:doi
3239:125
3169:PMC
3161:doi
3157:180
3121:doi
3113:106
3066:doi
3029:doi
2961:doi
2913:doi
2909:331
2876:doi
2872:157
2840:doi
2648:doi
2623:hdl
2595:hdl
2532:doi
2470:hdl
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1336:·2H
1238:).
1202:Dog
1194:2.8
1177:300
1174:Rat
1166:8.4
809:TGA
805:FDA
683:SNP
494:EPA
388:CID
242:POM
186:WHO
118:FDA
79:SNP
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