376:
353:
250:
275:
3654:
3684:
627:
3699:
3714:
3624:
3639:
3669:
31:
382:
281:
2105:, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
3341:
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JW, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M (April 2019). "Deubiquitinase USP10 regulates Notch signaling in the endothelium".
57:
2091:-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an
2400:
Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate".
3653:
2755:
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (December 2000). "MAML1, a human homologue of
Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors".
3141:
Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity".
3094:"Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription"
2898:"T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells"
3683:
389:
288:
3754:
2996:"The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway"
2109:, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
3698:
1795:
211:
1776:
2178:
3854:
3713:
3623:
3638:
3668:
3747:
3603:
2300:
3522:
Aster JC (2006). "Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities".
2282:
3875:
3294:"Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch"
1995:
375:
2002:
2849:"Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3"
352:
3740:
2343:
2269:
2248:
2265:
3407:
Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). "Notch signaling: cell fate control and signal integration in development".
3045:"Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex"
274:
249:
54:
2244:
2084:
191:
2152:
388:
287:
3186:"SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function"
381:
280:
3596:
2947:"Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain"
2319:"NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene & protein"
3662:: The Crystal Structure of a Partial Mouse Notch-1 Ankyrin Domain: Repeats 4 Through 7 Preserve an Ankyrin Fold
3570:
2363:
2092:
1840:
199:
2994:
Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (August 2002).
3775:
3767:
2088:
2068:
1821:
1321:
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
2800:"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors"
3807:
2512:
2113:
2708:"The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells"
2507:
3589:
3416:
3351:
3246:
2662:
2359:"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms"
263:
178:
3763:
3566:
2549:"Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1"
2106:
3547:
3510:
3385:
3323:
3166:
3123:
3074:
3025:
2976:
2780:
2737:
2688:
2488:
2437:
2087:
family share structural characteristics including an extracellular domain consisting of multiple
976:
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
223:
1978:
1957:
1931:
1910:
2847:
Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, Ibáñez CF (November 2003).
3539:
3502:
3467:
3432:
3377:
3315:
3274:
3215:
3158:
3115:
3066:
3017:
2968:
2927:
2878:
2829:
2772:
2729:
2680:
2631:
2581:
2529:
2480:
2429:
2382:
2096:
171:
47:
3732:
3531:
3492:
3457:
3424:
3367:
3359:
3305:
3264:
3254:
3205:
3197:
3150:
3105:
3056:
3007:
2958:
2917:
2909:
2868:
2860:
2819:
2811:
2764:
2719:
2670:
2621:
2613:
2571:
2561:
2521:
2508:"Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors"
2470:
2461:
2419:
2411:
2402:
2372:
626:
468:
399:
343:
298:
219:
182:, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
1551:
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
2080:
443:
3184:
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000).
3420:
3355:
3250:
2666:
30:
3269:
3234:
2922:
2897:
2873:
2848:
2626:
2600:
2576:
2553:
2548:
3154:
2824:
2799:
2675:
2650:
2475:
2456:
2415:
1710:
1705:
1700:
1695:
1690:
1685:
1680:
1675:
1670:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
3869:
3389:
3210:
3185:
2815:
2357:
McKellar SH, Tester DJ, Yagubyan M, Majumdar R, Ackerman MJ, Sundt TM (August 2007).
2140:
655:
3551:
3327:
3201:
3127:
3078:
3029:
2980:
2784:
2741:
2692:
2492:
2441:
3787:
3692:: Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
3514:
3170:
2617:
2605:
461:
240:
1391:
regulation of epithelial cell proliferation involved in prostate gland development
203:
3428:
3259:
3092:
Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997).
227:
2377:
2358:
2305:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2287:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2207:
2128:
2963:
2946:
2457:"Radial glial identity is promoted by Notch1 signaling in the murine forebrain"
1671:
negative regulation of cell proliferation involved in heart valve morphogenesis
544:
2189:
2139:
in an unidentified way. Reelin and Notch1 cooperate in the development of the
2101:
916:
epithelial to mesenchymal transition involved in endocardial cushion formation
360:
257:
207:
3372:
3110:
3093:
3363:
2344:"Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila)"
2132:
2124:
1740:
604:
482:
427:
414:
326:
313:
215:
3543:
3506:
3471:
3462:
3445:
3436:
3381:
3319:
3310:
3293:
3278:
3219:
3162:
3070:
3061:
3044:
3021:
3012:
2995:
2972:
2913:
2882:
2833:
2776:
2733:
2724:
2707:
2684:
2635:
2585:
2566:
2533:
2484:
2433:
2386:
3119:
2931:
2896:
Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T (May 1996).
2864:
2525:
2042:
2037:
3576:
3235:"AIP4/Itch regulates Notch receptor degradation in the absence of ligand"
2506:
Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS (March 2001).
2318:
2026:
1885:
1866:
3707:: Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.
3535:
3497:
3480:
2651:"Glycogen synthase kinase-3beta modulates notch signaling and stability"
1341:
negative regulation of cell migration involved in sprouting angiogenesis
739:
DNA-binding transcription activator activity, RNA polymerase II-specific
3849:
3844:
2945:
Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (July 2001).
2424:
2120:
1852:
1807:
1111:
negative regulation of inner ear auditory receptor cell differentiation
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
2601:"Reelin and Notch1 cooperate in the development of the dentate gyrus"
2136:
2010:
1762:
734:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
1706:
positive regulation of cardiac epithelial to mesenchymal transition
2768:
2219:
2183:
2172:
2160:
2131:
differentiation, but postnatally induces the differentiation into
2099:
that regulates interactions between physically adjacent cells. In
1701:
positive regulation of apoptotic process involved in morphogenesis
1725:
1721:
1676:
negative regulation of extracellular matrix constituent secretion
3823:
3818:
3797:
3792:
2599:
Sibbe M, Förster E, Basak O, Taylor V, Frotscher M (July 2009).
2201:
2195:
2064:
1576:
cellular response to vascular endothelial growth factor stimulus
195:
3736:
3585:
635:
3581:
2213:
2166:
1411:
positive regulation of receptor signaling pathway via JAK-STAT
1241:
regulation of inner ear auditory receptor cell differentiation
2798:
Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (November 2002).
1651:
positive regulation of transcription of Notch receptor target
3722:: Crystal structure of a human Notch1 ankyrin domain mutant
3632:: NMR Structure of a Prototype LNR Module from Human Notch1
1431:
apoptotic process involved in embryonic digit morphogenesis
1326:
positive regulation of epithelial to mesenchymal transition
3647:: NMR structure of the human NOTCH-1 ligand binding region
1101:
cellular response to follicle-stimulating hormone stimulus
1041:
vasculogenesis involved in coronary vascular morphogenesis
1601:
positive regulation of transcription by RNA polymerase II
1311:
negative regulation of transcription by RNA polymerase II
961:
negative regulation of photoreceptor cell differentiation
2649:
Foltz DR, Santiago MC, Berechid BE, Nye JS (June 2002).
1226:
cell migration involved in endocardial cushion formation
1211:
transcription initiation from RNA polymerase II promoter
996:
positive regulation of cardiac muscle cell proliferation
451:
3677:: Crystal structure of the human Notch 1 ankyrin domain
2135:. One study shows that Notch-1 cascade is activated by
1521:
negative regulation of calcium ion-dependent exocytosis
881:
positive regulation of endothelial cell differentiation
1641:
positive regulation of Ras protein signal transduction
1046:
negative regulation of canonical Wnt signaling pathway
991:
negative regulation of oligodendrocyte differentiation
3479:
Allenspach EJ, Maillard I, Aster JC, Pear WS (2003).
616:
1696:
negative regulation of biomineral tissue development
1536:
positive regulation of cell population proliferation
1261:
positive regulation of epithelial cell proliferation
1056:
negative regulation of cell population proliferation
3832:
3806:
3774:
3292:Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003).
3043:Nam Y, Weng AP, Aster JC, Blacklow SC (June 2003).
1971:
1950:
1924:
1903:
1396:
negative regulation of transcription, DNA-templated
1281:
positive regulation of keratinocyte differentiation
1166:
positive regulation of transcription, DNA-templated
2261:
2259:
2257:
2240:
2238:
2236:
1466:negative regulation of endothelial cell chemotaxis
2123:promote differentiation of progenitor cells into
1711:negative regulation of cold-induced thermogenesis
1681:negative regulation of cardiac muscle hypertrophy
1286:positive regulation of glial cell differentiation
1026:negative regulation of pro-B cell differentiation
941:negative regulation of osteoblast differentiation
398:
297:
2127:. Notch 1, when activated before birth, induces
1256:positive regulation of astrocyte differentiation
946:negative regulation of stem cell differentiation
921:regulation of transcription by RNA polymerase II
1386:positive regulation of viral genome replication
1086:negative regulation of myoblast differentiation
1066:positive regulation of neuroblast proliferation
911:negative regulation of glial cell proliferation
866:cardiac vascular smooth muscle cell development
16:Protein-coding gene in the species Homo sapiens
2266:GRCm38: Ensembl release 89: ENSMUSG00000026923
1691:homeostasis of number of cells within a tissue
1656:positive regulation of Notch signaling pathway
1541:negative regulation of myotube differentiation
1331:ventricular trabecula myocardium morphogenesis
1221:negative regulation of cell-substrate adhesion
3748:
3597:
2119:There is evidence that activated Notch 1 and
1421:Notch signaling involved in heart development
1406:branching morphogenesis of an epithelial tube
896:negative regulation of neuron differentiation
8:
1646:positive regulation of ERK1 and ERK2 cascade
1606:cardiac epithelial to mesenchymal transition
1476:negative regulation of BMP signaling pathway
1371:positive regulation of BMP signaling pathway
2706:Sade H, Krishna S, Sarin A (January 2004).
2245:GRCh38: Ensembl release 89: ENSG00000148400
1586:regulation of epithelial cell proliferation
1531:regulation of cell population proliferation
1251:inflammatory response to antigenic stimulus
1126:negative regulation of cell differentiation
901:regulation of extracellular matrix assembly
3755:
3741:
3733:
3604:
3590:
3582:
1736:
1616:positive regulation of aorta morphogenesis
1096:regulation of transcription, DNA-templated
651:
575:transitional epithelium of urinary bladder
439:
338:
235:
65:
3569:at the U.S. National Library of Medicine
3496:
3461:
3371:
3309:
3268:
3258:
3209:
3109:
3060:
3011:
2962:
2921:
2872:
2823:
2723:
2674:
2625:
2575:
2565:
2474:
2423:
2376:
2179:Mothers against decapentaplegic homolog 3
2067:. Notch 1 is a single-pass transmembrane
1336:neuronal stem cell population maintenance
1246:negative regulation of catalytic activity
966:arterial endothelial cell differentiation
724:transmembrane signaling receptor activity
674:DNA-binding transcription factor activity
2455:Gaiano N, Nye JS, Fishell G (May 2000).
2055:Neurogenic locus notch homolog protein 1
1546:positive regulation of apoptotic process
3619:
3233:Chastagner P, Israël A, Brou C (2008).
2232:
1236:venous endothelial cell differentiation
1176:prostate gland epithelium morphogenesis
1031:regulation of cardioblast proliferation
3446:"Notch signaling: from the outside in"
2060:is a protein encoded in humans by the
1686:positive regulation of gene expression
1631:negative regulation of gene expression
1496:auditory receptor cell fate commitment
1186:growth involved in heart morphogenesis
20:
1591:regulation of Notch signaling pathway
1451:positive regulation of cell migration
1296:glomerular mesangial cell development
403:
364:
359:
302:
261:
256:
7:
2112:A deficiency can be associated with
1511:determination of left/right symmetry
1376:skeletal muscle cell differentiation
1366:epithelial to mesenchymal transition
1141:cardiac left ventricle morphogenesis
971:atrioventricular valve morphogenesis
591:vestibular membrane of cochlear duct
1461:cardiac muscle tissue morphogenesis
1291:negative regulation of neurogenesis
1001:regulation of developmental process
951:negative regulation of ossification
891:cell differentiation in spinal cord
714:protein heterodimerization activity
2079:This gene encodes a member of the
1968:
1947:
1921:
1900:
1876:
1857:
1831:
1812:
1786:
1767:
1666:coronary sinus valve morphogenesis
1636:negative regulation of growth rate
1491:multicellular organism development
1216:cardiac right atrium morphogenesis
621:
539:
477:
456:
14:
2547:Keilani S, Sugaya K (July 2008).
1621:venous blood vessel morphogenesis
1481:endocardial cushion morphogenesis
1351:compartment pattern specification
1316:cardiac muscle cell proliferation
1266:cardiac right ventricle formation
1151:negative regulation of cell death
1081:atrioventricular node development
3712:
3697:
3682:
3667:
3652:
3637:
3622:
2816:10.1128/mcb.22.21.7688-7700.2002
1611:embryonic hindlimb morphogenesis
1156:endocardial cell differentiation
1121:ventricular septum morphogenesis
625:
387:
380:
374:
351:
286:
279:
273:
248:
29:
3202:10.1128/mcb.20.7.2400-2410.2000
1401:cardiac ventricle morphogenesis
1271:endocardial cushion development
931:oligodendrocyte differentiation
2618:10.1523/JNEUROSCI.0958-09.2009
1416:negative regulation of anoikis
1346:response to lipopolysaccharide
1146:in utero embryonic development
835:endoplasmic reticulum membrane
825:MAML1-RBP-Jkappa- ICN1 complex
800:integral component of membrane
636:More reference expression data
605:More reference expression data
1:
3155:10.1016/s0925-4773(01)00373-2
2676:10.1016/s0960-9822(02)00888-6
2476:10.1016/S0896-6273(00)81172-1
2416:10.1016/S0896-6273(01)00179-9
1596:left/right axis specification
1381:regulation of gene expression
1136:response to muramyl dipeptide
1131:coronary artery morphogenesis
1076:heart trabecula morphogenesis
876:pulmonary valve morphogenesis
709:sequence-specific DNA binding
559:vestibular sensory epithelium
372:
271:
3429:10.1126/science.284.5415.770
3260:10.1371/journal.pone.0002735
2085:type 1 transmembrane protein
1471:keratinocyte differentiation
1436:regulation of cell migration
1206:cardiac atrium morphogenesis
1181:embryonic limb morphogenesis
1161:transcription, DNA-templated
1116:cardiac septum morphogenesis
1006:mesenchymal cell development
3876:Genes on human chromosome 9
3481:"Notch signaling in cancer"
2378:10.1016/j.jtcvs.2007.02.041
1661:outflow tract morphogenesis
1426:coronary vein morphogenesis
1061:collecting duct development
1036:hair follicle morphogenesis
886:regulation of somitogenesis
729:signaling receptor activity
521:superficial temporal artery
3892:
3833:Receptor on receiving cell
2964:10.4049/jimmunol.167.1.289
1501:response to corticosteroid
1456:somatic stem cell division
1306:glial cell differentiation
1051:regulation of neurogenesis
926:aortic valve morphogenesis
3617:
3444:Mumm JS, Kopan R (2001).
2301:"Mouse PubMed Reference:"
2283:"Human PubMed Reference:"
2151:NOTCH1 has been shown to
2041:
2036:
2032:
2025:
2009:
1996:Chr 9: 136.49 – 136.55 Mb
1990:
1975:
1954:
1943:
1928:
1907:
1896:
1883:
1879:
1864:
1860:
1851:
1838:
1834:
1819:
1815:
1806:
1793:
1789:
1774:
1770:
1761:
1746:
1739:
1735:
1719:
1566:cardiac chamber formation
1516:astrocyte differentiation
1196:pericardium morphogenesis
1011:animal organ regeneration
936:endocardium morphogenesis
906:distal tubule development
684:enzyme inhibitor activity
654:
650:
633:
624:
615:
602:
551:
542:
489:
480:
450:
442:
438:
421:
408:
371:
350:
341:
337:
320:
307:
270:
247:
238:
234:
189:
186:
176:
169:
164:
73:
68:
51:
46:
41:
37:
28:
23:
3571:Medical Subject Headings
3111:10.1074/jbc.272.17.11336
2364:J Thorac Cardiovasc Surg
2143:, according to another.
2093:evolutionarily conserved
2083:family. Members of this
567:Rostral migratory stream
505:external globus pallidus
3768:notch signaling pathway
3364:10.1126/science.aat0778
2089:epidermal growth factor
2003:Chr 2: 26.35 – 26.41 Mb
1626:Notch signaling pathway
1486:endocardium development
1276:cell fate specification
1191:neural tube development
981:humoral immune response
3463:10.1006/dbio.2000.9960
3311:10.1074/jbc.M304353200
3062:10.1074/jbc.M301567200
3013:10.1074/jbc.M203727200
2914:10.1084/jem.183.5.2025
2725:10.1074/jbc.M309924200
2567:10.1186/1471-213X-8-69
1581:neuron fate commitment
1556:mitral valve formation
1361:neuron differentiation
1301:sprouting angiogenesis
790:apical plasma membrane
3567:NOTCH1+protein,+human
2865:10.1083/jcb.200305112
2526:10.1242/dev.128.5.689
2114:bicuspid aortic valve
1571:forebrain development
1201:epidermis development
986:foregut morphogenesis
795:endoplasmic reticulum
719:chromatin DNA binding
1231:cell differentiation
1091:cell fate commitment
871:endoderm development
775:extracellular region
563:vasculature of trunk
405:2 A3|2 18.91 cM
366:Chromosome 2 (mouse)
264:Chromosome 9 (human)
69:List of PDB id codes
42:Available structures
3536:10.1532/IJH97.05096
3498:10.4161/cbt.1.5.159
3421:1999Sci...284..770A
3356:2019Sci...364..188L
3251:2008PLoSO...3.2735C
2667:2002CBio...12.1006F
2107:trans-Golgi network
1446:tissue regeneration
850:cytoplasmic vesicle
669:calcium ion binding
579:conjunctival fornix
517:gingival epithelium
509:ganglionic eminence
497:epithelium of colon
1841:ENSMUSG00000026923
859:Biological process
748:Cellular component
662:Molecular function
228:NOTCH1 - orthologs
3863:
3862:
3778:on signaling cell
3764:Signaling pathway
3730:
3729:
3485:Cancer Biol. Ther
3373:20.500.12105/9685
3350:(6436): 188–193.
3006:(33): 29399–405.
2097:signaling pathway
2052:
2051:
2048:
2047:
2021:
2020:
1986:
1985:
1965:
1964:
1939:
1938:
1918:
1917:
1892:
1891:
1873:
1872:
1847:
1846:
1828:
1827:
1802:
1801:
1783:
1782:
1731:
1730:
1561:liver development
1526:brain development
1171:heart development
845:acrosomal vesicle
770:adherens junction
699:chromatin binding
689:metal ion binding
646:
645:
642:
641:
611:
610:
598:
597:
536:
535:
434:
433:
333:
332:
160:
159:
156:
155:
52:Ortholog search:
3883:
3757:
3750:
3743:
3734:
3716:
3701:
3686:
3671:
3656:
3641:
3626:
3606:
3599:
3592:
3583:
3555:
3518:
3500:
3475:
3465:
3440:
3394:
3393:
3375:
3338:
3332:
3331:
3313:
3289:
3283:
3282:
3272:
3262:
3230:
3224:
3223:
3213:
3181:
3175:
3174:
3138:
3132:
3131:
3113:
3104:(17): 11336–43.
3089:
3083:
3082:
3064:
3040:
3034:
3033:
3015:
2991:
2985:
2984:
2966:
2942:
2936:
2935:
2925:
2893:
2887:
2886:
2876:
2844:
2838:
2837:
2827:
2810:(21): 7688–700.
2795:
2789:
2788:
2752:
2746:
2745:
2727:
2703:
2697:
2696:
2678:
2646:
2640:
2639:
2629:
2596:
2590:
2589:
2579:
2569:
2544:
2538:
2537:
2503:
2497:
2496:
2478:
2452:
2446:
2445:
2427:
2397:
2391:
2390:
2380:
2354:
2348:
2347:
2340:
2334:
2333:
2331:
2329:
2315:
2309:
2308:
2297:
2291:
2290:
2279:
2273:
2263:
2252:
2242:
2034:
2033:
2005:
1998:
1981:
1969:
1960:
1948:
1944:RefSeq (protein)
1934:
1922:
1913:
1901:
1877:
1858:
1832:
1813:
1787:
1768:
1737:
1106:lung development
810:receptor complex
652:
638:
629:
622:
607:
547:
545:Top expressed in
540:
493:ventricular zone
485:
483:Top expressed in
478:
457:
440:
430:
417:
406:
391:
384:
378:
367:
355:
339:
329:
316:
305:
290:
283:
277:
266:
252:
236:
230:
181:
174:
151:
66:
60:
39:
38:
33:
21:
3891:
3890:
3886:
3885:
3884:
3882:
3881:
3880:
3866:
3865:
3864:
3859:
3828:
3802:
3770:
3761:
3731:
3726:
3723:
3717:
3708:
3702:
3693:
3687:
3678:
3672:
3663:
3657:
3648:
3642:
3633:
3627:
3613:
3610:
3563:
3558:
3524:Int. J. Hematol
3521:
3478:
3443:
3415:(5415): 770–6.
3406:
3402:
3400:Further reading
3397:
3340:
3339:
3335:
3304:(43): 41963–9.
3291:
3290:
3286:
3232:
3231:
3227:
3190:Mol. Cell. Biol
3183:
3182:
3178:
3140:
3139:
3135:
3091:
3090:
3086:
3055:(23): 21232–9.
3042:
3041:
3037:
2993:
2992:
2988:
2944:
2943:
2939:
2895:
2894:
2890:
2846:
2845:
2841:
2804:Mol. Cell. Biol
2797:
2796:
2792:
2754:
2753:
2749:
2705:
2704:
2700:
2661:(12): 1006–11.
2648:
2647:
2643:
2612:(26): 8578–85.
2598:
2597:
2593:
2546:
2545:
2541:
2505:
2504:
2500:
2454:
2453:
2449:
2399:
2398:
2394:
2356:
2355:
2351:
2342:
2341:
2337:
2327:
2325:
2323:www.uniprot.org
2317:
2316:
2312:
2299:
2298:
2294:
2281:
2280:
2276:
2264:
2255:
2243:
2234:
2230:
2225:
2149:
2077:
2043:View/Edit Mouse
2038:View/Edit Human
2001:
1994:
1991:Location (UCSC)
1977:
1956:
1930:
1909:
1822:ENSG00000148400
1715:
1356:immune response
1071:cilium assembly
1021:spermatogenesis
854:
815:plasma membrane
805:Golgi apparatus
743:
704:protein binding
634:
603:
594:
589:
585:
583:renal corpuscle
581:
577:
573:
569:
565:
561:
557:
543:
532:
527:
523:
519:
515:
511:
507:
503:
501:visceral pleura
499:
495:
481:
425:
412:
404:
394:
393:
392:
385:
365:
342:Gene location (
324:
311:
303:
293:
292:
291:
284:
262:
239:Gene location (
190:
177:
170:
75:
53:
17:
12:
11:
5:
3889:
3887:
3879:
3878:
3868:
3867:
3861:
3860:
3858:
3857:
3852:
3847:
3842:
3836:
3834:
3830:
3829:
3827:
3826:
3821:
3816:
3812:
3810:
3804:
3803:
3801:
3800:
3795:
3790:
3785:
3781:
3779:
3772:
3771:
3762:
3760:
3759:
3752:
3745:
3737:
3728:
3727:
3725:
3724:
3718:
3711:
3709:
3703:
3696:
3694:
3688:
3681:
3679:
3673:
3666:
3664:
3658:
3651:
3649:
3643:
3636:
3634:
3628:
3621:
3618:
3615:
3614:
3611:
3609:
3608:
3601:
3594:
3586:
3580:
3579:
3574:
3562:
3561:External links
3559:
3557:
3556:
3530:(4): 295–301.
3519:
3476:
3441:
3403:
3401:
3398:
3396:
3395:
3333:
3284:
3225:
3196:(7): 2400–10.
3176:
3133:
3084:
3035:
2986:
2937:
2908:(5): 2025–32.
2888:
2839:
2790:
2747:
2718:(4): 2937–44.
2698:
2641:
2591:
2554:BMC Dev. Biol.
2539:
2520:(5): 689–702.
2498:
2469:(2): 395–404.
2447:
2392:
2371:(2): 290–296.
2349:
2335:
2310:
2292:
2274:
2253:
2231:
2229:
2226:
2224:
2223:
2217:
2211:
2205:
2199:
2193:
2187:
2181:
2176:
2170:
2164:
2157:
2148:
2145:
2095:intercellular
2076:
2073:
2050:
2049:
2046:
2045:
2040:
2030:
2029:
2023:
2022:
2019:
2018:
2016:
2014:
2007:
2006:
1999:
1992:
1988:
1987:
1984:
1983:
1973:
1972:
1966:
1963:
1962:
1952:
1951:
1945:
1941:
1940:
1937:
1936:
1926:
1925:
1919:
1916:
1915:
1905:
1904:
1898:
1894:
1893:
1890:
1889:
1881:
1880:
1874:
1871:
1870:
1862:
1861:
1855:
1849:
1848:
1845:
1844:
1836:
1835:
1829:
1826:
1825:
1817:
1816:
1810:
1804:
1803:
1800:
1799:
1791:
1790:
1784:
1781:
1780:
1772:
1771:
1765:
1759:
1758:
1753:
1748:
1744:
1743:
1733:
1732:
1729:
1728:
1717:
1716:
1714:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1506:tube formation
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
862:
860:
856:
855:
853:
852:
847:
842:
840:Golgi membrane
837:
832:
830:cell periphery
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
751:
749:
745:
744:
742:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
694:enzyme binding
691:
686:
681:
676:
671:
665:
663:
659:
658:
648:
647:
644:
643:
640:
639:
631:
630:
619:
613:
612:
609:
608:
600:
599:
596:
595:
593:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
549:
548:
537:
534:
533:
531:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
487:
486:
474:
473:
465:
454:
448:
447:
444:RNA expression
436:
435:
432:
431:
423:
419:
418:
410:
407:
402:
396:
395:
386:
379:
373:
369:
368:
363:
357:
356:
348:
347:
335:
334:
331:
330:
322:
318:
317:
309:
306:
301:
295:
294:
285:
278:
272:
268:
267:
260:
254:
253:
245:
244:
232:
231:
188:
184:
183:
175:
167:
166:
162:
161:
158:
157:
154:
153:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3888:
3877:
3874:
3873:
3871:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3837:
3835:
3831:
3825:
3822:
3820:
3817:
3814:
3813:
3811:
3809:
3805:
3799:
3796:
3794:
3791:
3789:
3786:
3783:
3782:
3780:
3777:
3773:
3769:
3765:
3758:
3753:
3751:
3746:
3744:
3739:
3738:
3735:
3721:
3715:
3710:
3706:
3700:
3695:
3691:
3685:
3680:
3676:
3670:
3665:
3661:
3655:
3650:
3646:
3640:
3635:
3631:
3625:
3620:
3616:
3607:
3602:
3600:
3595:
3593:
3588:
3587:
3584:
3578:
3575:
3572:
3568:
3565:
3564:
3560:
3553:
3549:
3545:
3541:
3537:
3533:
3529:
3525:
3520:
3516:
3512:
3508:
3504:
3499:
3494:
3491:(5): 466–76.
3490:
3486:
3482:
3477:
3473:
3469:
3464:
3459:
3456:(2): 151–65.
3455:
3451:
3447:
3442:
3438:
3434:
3430:
3426:
3422:
3418:
3414:
3410:
3405:
3404:
3399:
3391:
3387:
3383:
3379:
3374:
3369:
3365:
3361:
3357:
3353:
3349:
3345:
3337:
3334:
3329:
3325:
3321:
3317:
3312:
3307:
3303:
3299:
3298:J. Biol. Chem
3295:
3288:
3285:
3280:
3276:
3271:
3266:
3261:
3256:
3252:
3248:
3244:
3240:
3236:
3229:
3226:
3221:
3217:
3212:
3207:
3203:
3199:
3195:
3191:
3187:
3180:
3177:
3172:
3168:
3164:
3160:
3156:
3152:
3149:(1–2): 3–20.
3148:
3144:
3137:
3134:
3129:
3125:
3121:
3117:
3112:
3107:
3103:
3099:
3098:J. Biol. Chem
3095:
3088:
3085:
3080:
3076:
3072:
3068:
3063:
3058:
3054:
3050:
3049:J. Biol. Chem
3046:
3039:
3036:
3031:
3027:
3023:
3019:
3014:
3009:
3005:
3001:
3000:J. Biol. Chem
2997:
2990:
2987:
2982:
2978:
2974:
2970:
2965:
2960:
2957:(1): 289–95.
2956:
2952:
2948:
2941:
2938:
2933:
2929:
2924:
2919:
2915:
2911:
2907:
2903:
2899:
2892:
2889:
2884:
2880:
2875:
2870:
2866:
2862:
2858:
2854:
2850:
2843:
2840:
2835:
2831:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2794:
2791:
2786:
2782:
2778:
2774:
2770:
2769:10.1038/82644
2766:
2762:
2758:
2751:
2748:
2743:
2739:
2735:
2731:
2726:
2721:
2717:
2713:
2712:J. Biol. Chem
2709:
2702:
2699:
2694:
2690:
2686:
2682:
2677:
2672:
2668:
2664:
2660:
2656:
2652:
2645:
2642:
2637:
2633:
2628:
2623:
2619:
2615:
2611:
2608:
2607:
2602:
2595:
2592:
2587:
2583:
2578:
2573:
2568:
2563:
2559:
2556:
2555:
2550:
2543:
2540:
2535:
2531:
2527:
2523:
2519:
2515:
2514:
2509:
2502:
2499:
2494:
2490:
2486:
2482:
2477:
2472:
2468:
2464:
2463:
2458:
2451:
2448:
2443:
2439:
2435:
2431:
2426:
2421:
2417:
2413:
2409:
2405:
2404:
2396:
2393:
2388:
2384:
2379:
2374:
2370:
2366:
2365:
2360:
2353:
2350:
2345:
2339:
2336:
2324:
2320:
2314:
2311:
2306:
2302:
2296:
2293:
2288:
2284:
2278:
2275:
2271:
2267:
2262:
2260:
2258:
2254:
2250:
2246:
2241:
2239:
2237:
2233:
2227:
2221:
2218:
2215:
2212:
2209:
2206:
2203:
2200:
2197:
2194:
2191:
2188:
2185:
2182:
2180:
2177:
2174:
2171:
2168:
2165:
2162:
2159:
2158:
2156:
2154:
2146:
2144:
2142:
2141:dentate gyrus
2138:
2134:
2130:
2126:
2122:
2117:
2115:
2110:
2108:
2104:
2103:
2098:
2094:
2090:
2086:
2082:
2074:
2072:
2070:
2066:
2063:
2059:
2056:
2044:
2039:
2035:
2031:
2028:
2024:
2017:
2015:
2012:
2008:
2004:
2000:
1997:
1993:
1989:
1982:
1980:
1974:
1970:
1967:
1961:
1959:
1953:
1949:
1946:
1942:
1935:
1933:
1927:
1923:
1920:
1914:
1912:
1906:
1902:
1899:
1897:RefSeq (mRNA)
1895:
1888:
1887:
1882:
1878:
1875:
1869:
1868:
1863:
1859:
1856:
1854:
1850:
1843:
1842:
1837:
1833:
1830:
1824:
1823:
1818:
1814:
1811:
1809:
1805:
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956:heart looping
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679:Notch binding
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656:Gene ontology
653:
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555:hair follicle
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3484:
3453:
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3408:
3347:
3343:
3336:
3301:
3297:
3287:
3245:(7): e2735.
3242:
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3228:
3193:
3189:
3179:
3146:
3142:
3136:
3101:
3097:
3087:
3052:
3048:
3038:
3003:
2999:
2989:
2954:
2950:
2940:
2905:
2901:
2891:
2859:(4): 723–8.
2856:
2853:J. Cell Biol
2852:
2842:
2807:
2803:
2793:
2763:(4): 484–9.
2760:
2756:
2750:
2715:
2711:
2701:
2658:
2654:
2644:
2609:
2606:J. Neurosci.
2604:
2594:
2557:
2552:
2542:
2517:
2511:
2501:
2466:
2460:
2450:
2410:(1): 45–55.
2407:
2401:
2395:
2368:
2362:
2352:
2338:
2326:. Retrieved
2322:
2313:
2304:
2295:
2286:
2277:
2150:
2147:Interactions
2118:
2111:
2100:
2078:
2061:
2057:
2054:
2053:
1976:
1955:
1929:
1908:
1884:
1865:
1839:
1820:
1794:
1775:
1755:
1750:
1441:axonogenesis
1016:angiogenesis
785:cell surface
587:skin of back
467:
460:
325:136,546,048
312:136,494,433
187:External IDs
74:
18:
3612:PDB gallery
2902:J. Exp. Med
2513:Development
2425:2433/150564
2208:Ubiquitin C
2129:radial glia
820:nucleoplasm
571:granulocyte
525:granulocyte
426:26,406,675
413:26,347,915
165:Identifiers
2951:J. Immunol
2757:Nat. Genet
2655:Curr. Biol
2272:, May 2017
2251:, May 2017
2228:References
2133:astrocytes
2102:Drosophila
471:(ortholog)
208:HomoloGene
3450:Dev. Biol
3390:109940358
3143:Mech. Dev
2560:(1): 69.
2125:astroglia
2058:(Notch 1)
1979:NP_032740
1958:NP_060087
1932:NM_008714
1911:NM_017617
1741:Orthologs
755:cytoplasm
216:GeneCards
3870:Category
3776:Receptor
3552:32528011
3544:16298817
3507:12496471
3472:11112321
3437:10221902
3382:30975888
3328:23574059
3320:12913000
3279:18628966
3239:PLOS ONE
3220:10713164
3163:11404076
3128:36236215
3079:13637961
3071:12644465
3030:26465428
3022:12050162
2981:22399328
2973:11418662
2883:14638857
2834:12370315
2785:23335042
2777:11101851
2742:42454311
2734:14583609
2693:15884556
2685:12123574
2636:19571148
2586:18593473
2534:11171394
2493:15861936
2485:10839358
2442:17047028
2434:11182080
2387:17662764
2268:–
2247:–
2153:interact
2075:Function
2069:receptor
2027:Wikidata
1720:Sources:
765:membrane
3855:Notch 4
3850:Notch 3
3845:Notch 2
3840:Notch 1
3515:1328739
3417:Bibcode
3409:Science
3352:Bibcode
3344:Science
3270:2444042
3247:Bibcode
3171:9526831
3120:9111040
2932:8642313
2923:2192574
2874:2173673
2663:Bibcode
2627:6665659
2577:2447831
2270:Ensembl
2249:Ensembl
2121:Notch 3
1853:UniProt
1808:Ensembl
1747:Species
1726:QuickGO
780:nucleus
760:cytosol
446:pattern
172:Aliases
3815:Jagged
3808:Ligand
3577:NOTCH1
3573:(MeSH)
3550:
3542:
3513:
3505:
3470:
3435:
3388:
3380:
3326:
3318:
3277:
3267:
3218:
3208:
3169:
3161:
3126:
3118:
3077:
3069:
3028:
3020:
2979:
2971:
2930:
2920:
2881:
2871:
2832:
2825:135662
2822:
2783:
2775:
2740:
2732:
2691:
2683:
2634:
2624:
2584:
2574:
2532:
2491:
2483:
2462:Neuron
2440:
2432:
2403:Neuron
2385:
2328:23 May
2155:with:
2137:Reelin
2062:NOTCH1
2013:search
2011:PubMed
1886:Q01705
1867:P46531
1763:Entrez
617:BioGPS
304:9q34.3
220:NOTCH1
196:190198
179:NOTCH1
24:NOTCH1
3784:Delta
3548:S2CID
3511:S2CID
3386:S2CID
3324:S2CID
3211:85419
3167:S2CID
3124:S2CID
3075:S2CID
3026:S2CID
2977:S2CID
2781:S2CID
2738:S2CID
2689:S2CID
2489:S2CID
2438:S2CID
2220:USP10
2210:, and
2184:NFKB1
2173:MAML1
2161:GSK3B
2081:Notch
1796:18128
1756:Mouse
1751:Human
1722:Amigo
529:vulva
513:blood
469:Mouse
462:Human
409:Start
344:Mouse
308:Start
241:Human
212:32049
204:97363
3824:JAG2
3819:JAG1
3798:DLL4
3793:DLL3
3788:DLL1
3720:2he0
3705:2f8y
3690:2f8x
3675:1yyh
3660:1ymp
3645:1toz
3630:1pb5
3540:PMID
3503:PMID
3468:PMID
3433:PMID
3378:PMID
3316:PMID
3275:PMID
3216:PMID
3159:PMID
3116:PMID
3067:PMID
3018:PMID
2969:PMID
2928:PMID
2879:PMID
2830:PMID
2773:PMID
2730:PMID
2681:PMID
2632:PMID
2582:PMID
2530:PMID
2481:PMID
2430:PMID
2383:PMID
2330:2022
2202:SNW1
2196:RBPJ
2065:gene
1777:4851
452:Bgee
400:Band
361:Chr.
299:Band
258:Chr.
192:OMIM
149:5FMA
145:5FM9
141:4D0F
137:4D0E
133:4CUF
129:4CUE
125:4CUD
121:3V79
117:3NBN
113:3L95
109:3I08
105:3ETO
101:2VJ3
97:2HE0
93:2F8Y
89:2F8X
85:1YYH
81:1TOZ
77:1PB5
58:RCSB
55:PDBe
3532:doi
3493:doi
3458:doi
3454:228
3425:doi
3413:284
3368:hdl
3360:doi
3348:364
3306:doi
3302:278
3265:PMC
3255:doi
3206:PMC
3198:doi
3151:doi
3147:104
3106:doi
3102:272
3057:doi
3053:278
3008:doi
3004:277
2959:doi
2955:167
2918:PMC
2910:doi
2906:183
2869:PMC
2861:doi
2857:163
2820:PMC
2812:doi
2765:doi
2720:doi
2716:279
2671:doi
2622:PMC
2614:doi
2572:PMC
2562:doi
2522:doi
2518:128
2471:doi
2420:hdl
2412:doi
2373:doi
2369:134
2214:YY1
2190:NOV
2167:Lck
422:End
321:End
224:OMA
200:MGI
48:PDB
3872::
3766::
3546:.
3538:.
3528:82
3526:.
3509:.
3501:.
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2285:.
2256:^
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