304:
281:
178:
203:
569:
562:
555:
2615:
31:
310:
209:
1238:) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In
1244:, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
1471:
Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, Brain CE, Burton BK, Kim KH, Pauli RM, Aftimos S, Stewart H, Kim CA, Holder-Espinasse M, Robertson SP, Drake WM, Trembath RC (2011-03-06). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and
1435:
Samejima H, Torii C, Kosaki R, Kurosawa K, Yoshihashi H, Muroya K, Okamoto N, Watanabe Y, Kosho T, Kubota M, Matsuda O, Goto M, Izumi K, Takahashi T, Kosaki K (2007). "Screening for
Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography".
1573:
Isidor B, Lindenbaum P, Pichon O, Bézieau S, Dina C, Jacquemont S, Martin-Coignard D, Thauvin-Robinet C, Le Merrer M, Mandel JL, David A, Faivre L, Cormier-Daire V, Redon R, Le
Caignec C (2011). "Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis".
57:
2054:
Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci".
1399:
Larsson C, Lardelli M, White I, Lendahl U (May 1995). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation".
1529:
Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, et al. (2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss".
2371:
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (2001). "MAML1, a human homologue of
Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors".
2017:
Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (1993). "Human homologs of a
Drosophila Enhancer of split gene product define a novel family of nuclear proteins".
1248:, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
317:
216:
2655:
1617:
Majewski J, Schwartzentruber JA, Caqueret A, Patry L, Marcadier J, Fryns JP, Boycott KM, Ste-Marie LG, McKiernan FE, Marik I, Van Esch H, Michaud JL, Samuels ME (2011).
2408:
Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW (2001). "Notch signaling induces cell cycle arrest in small cell lung cancer cells".
2614:
922:
903:
139:
2755:
1980:
Schwarzmeier JD, Hubmann R, Düchler M, Jäger U, Shehata M (2005). "Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia".
2213:
Berezovska O, Xia MQ, Hyman BT (1998). "Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in
Alzheimer disease".
2648:
2594:
1381:
1363:
2776:
2431:"Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"
1671:"Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"
2330:"Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2"
1717:"Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2"
1130:
303:
1137:
280:
2641:
2250:
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999).
1515:
1350:
1329:
1234:
family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (
2546:
1346:
1900:
Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). "Notch signaling: cell fate control and signal integration in development".
202:
177:
54:
1325:
1260:
1231:
119:
1276:
316:
215:
1815:"Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways"
309:
208:
1264:
1215:
2587:
967:
127:
2295:"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods"
1856:"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods"
2541:
2676:
2668:
1235:
1227:
948:
1854:
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (November 1999).
1715:
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000).
2708:
2580:
1909:
191:
106:
2664:
1088:
1037:
2293:
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (2000).
2396:
2238:
2158:
2042:
2005:
1933:
1795:
1648:
1599:
1555:
1497:
151:
2328:
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000).
1113:
1092:
1062:
1041:
568:
561:
554:
2552:
2522:
2487:
2452:
2417:
2388:
2359:
2316:
2281:
2230:
2201:
2150:
2115:
2072:
2034:
1997:
1968:
1925:
1877:
1836:
1787:
1746:
1692:
1640:
1591:
1547:
1489:
1453:
1417:
1211:
99:
47:
2633:
2512:
2477:
2442:
2380:
2349:
2341:
2306:
2271:
2263:
2222:
2191:
2183:
2140:
2105:
2097:
2064:
2026:
1989:
1958:
1917:
1867:
1826:
1777:
1736:
1728:
1682:
1630:
1583:
1539:
1481:
1445:
1409:
396:
327:
271:
226:
147:
2086:"Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation"
2129:"Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane"
1766:"Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane"
1245:
371:
1913:
30:
2276:
2251:
2501:"Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation"
2267:
2196:
2172:"Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines"
2171:
2145:
2128:
2110:
2085:
1963:
1946:
1782:
1765:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
620:
615:
610:
2770:
2561:
2354:
2345:
2329:
2226:
1741:
1732:
1716:
1603:
1559:
1501:
1256:
597:
2400:
2242:
2162:
2101:
2046:
2009:
1937:
1799:
1652:
2688:
1283:
389:
168:
131:
1921:
155:
1386:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1368:
National Center for
Biotechnology Information, U.S. National Library of Medicine
472:
1993:
1240:
288:
185:
135:
2311:
2294:
1872:
1855:
867:
532:
410:
355:
342:
254:
241:
143:
2526:
2517:
2500:
2491:
2482:
2465:
2456:
2447:
2430:
2421:
2392:
2363:
2320:
2285:
2068:
2001:
1972:
1929:
1881:
1840:
1831:
1814:
1750:
1696:
1687:
1670:
1644:
1595:
1551:
1493:
1457:
1413:
2234:
2205:
2187:
2154:
2119:
2076:
2038:
1791:
1449:
1421:
1177:
1172:
1669:
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001).
1161:
1012:
993:
2750:
2740:
2566:
2556:
2466:"Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis"
2030:
1635:
1618:
1197:
979:
934:
76:
2623:: Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
1145:
889:
2429:
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (2001).
1764:
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997).
2499:
Inglés-Esteve J, Espinosa L, Milner LA, Caelles C, Bigas A (2002).
1587:
1543:
1485:
2384:
1288:
852:
848:
2724:
2719:
2698:
2693:
1813:
Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A (August 2003).
1300:
1294:
1204:
123:
2637:
2576:
2127:
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997).
577:
2572:
2551:
Overview of all the structural information available in the
1619:"Mutations in NOTCH2 in families with Hajdu-Cheney syndrome"
2084:
Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (1997).
788:
transcription initiation from RNA polymerase II promoter
379:
733:
positive regulation of Ras protein signal transduction
110:, AGS2, HJCYS, hN2, Notch-2, notch 2, notch receptor 2
544:
2733:
2707:
2675:
1106:
1081:
1055:
1030:
2565:(Neurogenic locus notch homolog protein 2) at the
2542:GeneReviews/NCBI/UW/NIH entry on Alagille syndrome
2464:Saxena MT, Schroeter EH, Mumm JS, Kopan R (2001).
1516:"Entrez Gene: NOTCH2 Notch homolog 2 (Drosophila)"
1342:
1340:
1338:
1321:
1319:
1317:
833:positive regulation of keratinocyte proliferation
326:
225:
1710:
1708:
1706:
1664:
1662:
838:regulation of actin cytoskeleton reorganization
1347:GRCm38: Ensembl release 89: ENSMUSG00000027878
2649:
2588:
793:Notch signaling involved in heart development
8:
1263:have been shown to be the main cause of the
823:positive regulation of ERK1 and ERK2 cascade
1326:GRCh38: Ensembl release 89: ENSG00000134250
2656:
2642:
2634:
2595:
2581:
2573:
863:
728:regulation of transcription, DNA-templated
593:
367:
266:
163:
65:
2516:
2481:
2446:
2353:
2310:
2275:
2195:
2144:
2109:
1962:
1871:
1830:
1781:
1740:
1686:
1634:
1251:Mutations within the last coding exon of
1190:Neurogenic locus notch homolog protein 2
808:intracellular receptor signaling pathway
738:negative regulation of apoptotic process
2610:
1313:
2170:Bigas A, Martin DI, Milner LA (1998).
813:negative regulation of gene expression
20:
2252:"Human ligands of the Notch receptor"
672:integral component of plasma membrane
331:
292:
287:
230:
189:
184:
7:
828:regulation of osteoclast development
743:marginal zone B cell differentiation
1947:"Notch receptors and hematopoiesis"
773:regulation of developmental process
1103:
1078:
1052:
1027:
1003:
984:
958:
939:
913:
894:
818:negative regulation of growth rate
763:multicellular organism development
549:
467:
405:
384:
14:
2547:OMIM entries on Alagille syndrome
1200:that in humans is encoded by the
2613:
2346:10.1128/MCB.20.18.6913-6922.2000
2227:10.1097/00005072-199808000-00003
1733:10.1128/mcb.20.18.6913-6922.2000
758:stem cell population maintenance
567:
560:
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
2102:10.1128/JVI.71.3.1938-1945.1997
647:endoplasmic reticulum membrane
642:integral component of membrane
578:More reference expression data
533:More reference expression data
1:
2268:10.1016/S0002-9440(10)65325-4
2146:10.1016/S0092-8674(00)80336-0
1964:10.1016/S0301-472X(01)00676-2
1945:Kojika S, Griffin JD (2001).
1783:10.1016/s0092-8674(00)80336-0
723:pulmonary valve morphogenesis
503:vestibular sensory epithelium
300:
199:
1922:10.1126/science.284.5415.770
1261:nonsense-mediated mRNA decay
1232:type 1 transmembrane protein
748:transcription, DNA-templated
2777:Genes on human chromosome 1
2215:J. Neuropathol. Exp. Neurol
1226:Notch 2 is a member of the
768:atrial septum morphogenesis
621:signaling receptor activity
2793:
2734:Receptor on receiving cell
1210:NOTCH2 is associated with
783:animal organ morphogenesis
753:nervous system development
487:retinal pigment epithelium
421:retinal pigment epithelium
2608:
1994:10.1080/10428190400010742
1382:"Mouse PubMed Reference:"
1364:"Human PubMed Reference:"
1275:NOTCH2 has been shown to
1176:
1171:
1167:
1160:
1144:
1125:
1110:
1085:
1074:
1059:
1034:
1023:
1010:
1006:
991:
987:
978:
965:
961:
946:
942:
933:
920:
916:
901:
897:
888:
873:
866:
862:
846:
596:
592:
575:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
2312:10.1074/jbc.274.46.32961
1873:10.1074/jbc.274.46.32961
1472:progressive bone loss".
1230:family. Members of this
1131:Chr 1: 119.91 – 120.1 Mb
2669:notch signaling pathway
1138:Chr 3: 97.92 – 98.06 Mb
803:cell fate determination
708:Notch signaling pathway
18:Protein found in humans
2518:10.1074/jbc.M104703200
2483:10.1074/jbc.M107234200
2448:10.1074/jbc.M103473200
2069:10.1006/geno.1996.0328
1832:10.1074/jbc.M304001200
1688:10.1074/jbc.M103473200
1414:10.1006/geno.1994.1613
1259:domain and escape the
333:3 F2.2|3 42.42 cM
2188:10.1128/mcb.18.4.2324
1450:10.1089/gte.2006.0519
1265:Hajdu–Cheney syndrome
1216:Hajdu–Cheney syndrome
713:cell differentiation
682:extracellular region
294:Chromosome 3 (mouse)
192:Chromosome 1 (human)
69:List of PDB id codes
42:Available structures
1914:1999Sci...284..770A
1246:trans-Golgi network
611:calcium ion binding
511:conjunctival fornix
2031:10.1038/ng1092-119
1636:10.1002/humu.21546
968:ENSMUSG00000027878
701:Biological process
630:Cellular component
604:Molecular function
515:epithelium of lens
453:tail of epididymis
156:NOTCH2 - orthologs
2764:
2763:
2679:on signaling cell
2665:Signaling pathway
2631:
2630:
1255:that remove the
1212:Alagille syndrome
1187:
1186:
1183:
1182:
1156:
1155:
1121:
1120:
1100:
1099:
1070:
1069:
1049:
1048:
1019:
1018:
1000:
999:
974:
973:
955:
954:
929:
928:
910:
909:
858:
857:
798:apoptotic process
588:
587:
584:
583:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
2784:
2658:
2651:
2644:
2635:
2617:
2597:
2590:
2583:
2574:
2530:
2520:
2511:(48): 44873–80.
2495:
2485:
2476:(43): 40268–73.
2460:
2450:
2425:
2404:
2367:
2357:
2324:
2314:
2289:
2279:
2246:
2209:
2199:
2166:
2148:
2123:
2113:
2080:
2050:
2013:
1976:
1966:
1941:
1886:
1885:
1875:
1851:
1845:
1844:
1834:
1825:(34): 32227–35.
1810:
1804:
1803:
1785:
1761:
1755:
1754:
1744:
1712:
1701:
1700:
1690:
1666:
1657:
1656:
1638:
1614:
1608:
1607:
1570:
1564:
1563:
1526:
1520:
1519:
1512:
1506:
1505:
1468:
1462:
1461:
1432:
1426:
1425:
1396:
1390:
1389:
1378:
1372:
1371:
1360:
1354:
1344:
1333:
1323:
1169:
1168:
1140:
1133:
1116:
1104:
1095:
1079:
1075:RefSeq (protein)
1065:
1053:
1044:
1028:
1004:
985:
959:
940:
914:
895:
864:
662:receptor complex
594:
580:
571:
564:
557:
550:
535:
475:
473:Top expressed in
468:
449:lactiferous duct
441:caput epididymis
433:ventricular zone
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
2792:
2791:
2787:
2786:
2785:
2783:
2782:
2781:
2767:
2766:
2765:
2760:
2729:
2703:
2671:
2662:
2632:
2627:
2624:
2618:
2604:
2601:
2538:
2533:
2498:
2463:
2441:(28): 25753–8.
2428:
2407:
2370:
2340:(18): 6913–22.
2334:Mol. Cell. Biol
2327:
2305:(46): 32961–9.
2292:
2249:
2212:
2176:Mol. Cell. Biol
2169:
2126:
2083:
2053:
2016:
1979:
1944:
1908:(5415): 770–6.
1899:
1895:
1893:Further reading
1890:
1889:
1866:(46): 32961–9.
1853:
1852:
1848:
1812:
1811:
1807:
1763:
1762:
1758:
1727:(18): 6913–22.
1721:Mol. Cell. Biol
1714:
1713:
1704:
1681:(28): 25753–8.
1668:
1667:
1660:
1616:
1615:
1611:
1576:Nature Genetics
1572:
1571:
1567:
1532:Nature Genetics
1528:
1527:
1523:
1514:
1513:
1509:
1474:Nature Genetics
1470:
1469:
1465:
1434:
1433:
1429:
1398:
1397:
1393:
1380:
1379:
1375:
1362:
1361:
1357:
1345:
1336:
1324:
1315:
1310:
1273:
1224:
1178:View/Edit Mouse
1173:View/Edit Human
1136:
1129:
1126:Location (UCSC)
1112:
1091:
1087:
1061:
1040:
1036:
949:ENSG00000134250
842:
778:bone remodeling
696:
667:plasma membrane
625:
616:protein binding
576:
566:
565:
559:
558:
531:
522:
517:
513:
509:
505:
501:
497:
495:ascending aorta
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
19:
12:
11:
5:
2790:
2788:
2780:
2779:
2769:
2768:
2762:
2761:
2759:
2758:
2753:
2748:
2743:
2737:
2735:
2731:
2730:
2728:
2727:
2722:
2717:
2713:
2711:
2705:
2704:
2702:
2701:
2696:
2691:
2686:
2682:
2680:
2673:
2672:
2663:
2661:
2660:
2653:
2646:
2638:
2629:
2628:
2626:
2625:
2619:
2612:
2609:
2606:
2605:
2602:
2600:
2599:
2592:
2585:
2577:
2571:
2570:
2549:
2544:
2537:
2536:External links
2534:
2532:
2531:
2496:
2461:
2426:
2405:
2368:
2325:
2290:
2247:
2210:
2182:(4): 2324–33.
2167:
2124:
2096:(3): 1938–45.
2081:
2051:
2014:
1982:Leuk. Lymphoma
1977:
1957:(9): 1041–52.
1942:
1896:
1894:
1891:
1888:
1887:
1846:
1805:
1756:
1702:
1658:
1629:(10): 1114–7.
1609:
1588:10.1038/ng.778
1565:
1544:10.1038/ng.779
1538:(4): 303–305.
1521:
1507:
1486:10.1038/ng.779
1463:
1427:
1391:
1373:
1355:
1334:
1312:
1311:
1309:
1306:
1305:
1304:
1298:
1292:
1286:
1272:
1269:
1223:
1220:
1185:
1184:
1181:
1180:
1175:
1165:
1164:
1158:
1157:
1154:
1153:
1151:
1149:
1142:
1141:
1134:
1127:
1123:
1122:
1119:
1118:
1108:
1107:
1101:
1098:
1097:
1083:
1082:
1076:
1072:
1071:
1068:
1067:
1057:
1056:
1050:
1047:
1046:
1032:
1031:
1025:
1021:
1020:
1017:
1016:
1008:
1007:
1001:
998:
997:
989:
988:
982:
976:
975:
972:
971:
963:
962:
956:
953:
952:
944:
943:
937:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
880:
875:
871:
870:
860:
859:
856:
855:
844:
843:
841:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
704:
702:
698:
697:
695:
694:
689:
684:
679:
674:
669:
664:
659:
657:Golgi membrane
654:
649:
644:
639:
633:
631:
627:
626:
624:
623:
618:
613:
607:
605:
601:
600:
590:
589:
586:
585:
582:
581:
573:
572:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
437:synovial joint
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2789:
2778:
2775:
2774:
2772:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2738:
2736:
2732:
2726:
2723:
2721:
2718:
2715:
2714:
2712:
2710:
2706:
2700:
2697:
2695:
2692:
2690:
2687:
2684:
2683:
2681:
2678:
2674:
2670:
2666:
2659:
2654:
2652:
2647:
2645:
2640:
2639:
2636:
2622:
2616:
2611:
2607:
2598:
2593:
2591:
2586:
2584:
2579:
2578:
2575:
2568:
2564:
2563:
2558:
2554:
2550:
2548:
2545:
2543:
2540:
2539:
2535:
2528:
2524:
2519:
2514:
2510:
2506:
2505:J. Biol. Chem
2502:
2497:
2493:
2489:
2484:
2479:
2475:
2471:
2470:J. Biol. Chem
2467:
2462:
2458:
2454:
2449:
2444:
2440:
2436:
2435:J. Biol. Chem
2432:
2427:
2423:
2419:
2416:(7): 3200–5.
2415:
2411:
2406:
2402:
2398:
2394:
2390:
2386:
2385:10.1038/82644
2382:
2378:
2374:
2369:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2335:
2331:
2326:
2322:
2318:
2313:
2308:
2304:
2300:
2299:J. Biol. Chem
2296:
2291:
2287:
2283:
2278:
2273:
2269:
2265:
2262:(3): 785–94.
2261:
2257:
2256:Am. J. Pathol
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2221:(8): 738–45.
2220:
2216:
2211:
2207:
2203:
2198:
2193:
2189:
2185:
2181:
2177:
2173:
2168:
2164:
2160:
2156:
2152:
2147:
2142:
2139:(2): 281–91.
2138:
2134:
2130:
2125:
2121:
2117:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2025:(2): 119–27.
2024:
2020:
2015:
2011:
2007:
2003:
1999:
1995:
1991:
1988:(2): 157–65.
1987:
1983:
1978:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1943:
1939:
1935:
1931:
1927:
1923:
1919:
1915:
1911:
1907:
1903:
1898:
1897:
1892:
1883:
1879:
1874:
1869:
1865:
1861:
1860:J. Biol. Chem
1857:
1850:
1847:
1842:
1838:
1833:
1828:
1824:
1820:
1819:J. Biol. Chem
1816:
1809:
1806:
1801:
1797:
1793:
1789:
1784:
1779:
1776:(2): 281–91.
1775:
1771:
1767:
1760:
1757:
1752:
1748:
1743:
1738:
1734:
1730:
1726:
1722:
1718:
1711:
1709:
1707:
1703:
1698:
1694:
1689:
1684:
1680:
1676:
1675:J. Biol. Chem
1672:
1665:
1663:
1659:
1654:
1650:
1646:
1642:
1637:
1632:
1628:
1624:
1620:
1613:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1569:
1566:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1525:
1522:
1517:
1511:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1467:
1464:
1459:
1455:
1451:
1447:
1444:(3): 216–27.
1443:
1439:
1431:
1428:
1423:
1419:
1415:
1411:
1407:
1403:
1395:
1392:
1387:
1383:
1377:
1374:
1369:
1365:
1359:
1356:
1352:
1348:
1343:
1341:
1339:
1335:
1331:
1327:
1322:
1320:
1318:
1314:
1307:
1302:
1299:
1296:
1293:
1290:
1287:
1285:
1282:
1281:
1280:
1278:
1270:
1268:
1266:
1262:
1258:
1254:
1249:
1247:
1243:
1242:
1237:
1233:
1229:
1221:
1219:
1217:
1213:
1208:
1206:
1203:
1199:
1195:
1191:
1179:
1174:
1170:
1166:
1163:
1159:
1152:
1150:
1147:
1143:
1139:
1135:
1132:
1128:
1124:
1117:
1115:
1109:
1105:
1102:
1096:
1094:
1090:
1084:
1080:
1077:
1073:
1066:
1064:
1058:
1054:
1051:
1045:
1043:
1039:
1033:
1029:
1026:
1024:RefSeq (mRNA)
1022:
1015:
1014:
1009:
1005:
1002:
996:
995:
990:
986:
983:
981:
977:
970:
969:
964:
960:
957:
951:
950:
945:
941:
938:
936:
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
884:
881:
879:
876:
872:
869:
865:
861:
854:
850:
845:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
705:
703:
700:
699:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
634:
632:
629:
628:
622:
619:
617:
614:
612:
609:
608:
606:
603:
602:
599:
598:Gene ontology
595:
591:
579:
574:
570:
563:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
436:
432:
429:skin of thigh
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
2745:
2620:
2560:
2508:
2504:
2473:
2469:
2438:
2434:
2413:
2409:
2379:(4): 484–9.
2376:
2372:
2337:
2333:
2302:
2298:
2259:
2255:
2218:
2214:
2179:
2175:
2136:
2132:
2093:
2089:
2063:(1): 101–8.
2060:
2056:
2022:
2018:
1985:
1981:
1954:
1951:Exp. Hematol
1950:
1905:
1901:
1863:
1859:
1849:
1822:
1818:
1808:
1773:
1769:
1759:
1724:
1720:
1678:
1674:
1626:
1622:
1612:
1582:(4): 306–8.
1579:
1575:
1568:
1535:
1531:
1524:
1510:
1480:(4): 303–5.
1477:
1473:
1466:
1441:
1437:
1430:
1408:(2): 253–8.
1405:
1401:
1394:
1385:
1376:
1367:
1358:
1284:Delta-like 1
1274:
1271:Interactions
1252:
1250:
1239:
1225:
1209:
1201:
1193:
1189:
1188:
1111:
1089:NP_001186930
1086:
1060:
1038:NM_001200001
1035:
1011:
992:
966:
947:
921:
902:
882:
877:
687:cell surface
507:cumulus cell
499:vas deferens
491:aortic valve
483:ciliary body
395:
388:
253:120,100,779
240:119,911,553
115:External IDs
74:
15:
2603:PDB gallery
1438:Genet. Test
718:hemopoiesis
677:nucleoplasm
457:skin of arm
425:skin of hip
354:98,057,677
341:97,920,843
93:Identifiers
2410:Cancer Res
2373:Nat. Genet
2019:Nat. Genet
1353:, May 2017
1332:, May 2017
1308:References
1241:Drosophila
399:(ortholog)
136:HomoloGene
1623:Hum Mutat
1604:205357384
1560:205357391
1502:205357391
1114:NP_035058
1093:NP_077719
1063:NM_010928
1042:NM_024408
868:Orthologs
637:cytoplasm
144:GeneCards
2771:Category
2677:Receptor
2527:11577080
2492:11518718
2457:11346656
2422:11306509
2401:23335042
2393:11101851
2364:10958687
2321:10551863
2286:10079256
2243:23509744
2163:16544864
2090:J. Virol
2057:Genomics
2047:32142845
2010:36863790
2002:15621797
1973:11532344
1938:16790253
1930:10221902
1882:10551863
1841:12794074
1800:16544864
1751:10958687
1697:11346656
1653:39342783
1645:21681853
1596:21378989
1552:21378985
1494:21378985
1458:17949281
1402:Genomics
1349:–
1328:–
1277:interact
1222:Function
1162:Wikidata
847:Sources:
652:membrane
2756:Notch 4
2751:Notch 3
2746:Notch 2
2741:Notch 1
2567:PDBe-KB
2557:UniProt
2277:1866435
2235:9720489
2206:9528802
2155:9244302
2120:9032325
2077:8661110
2039:1303260
1910:Bibcode
1902:Science
1792:9244302
1422:7698746
1351:Ensembl
1330:Ensembl
1198:protein
1196:) is a
1194:Notch 2
980:UniProt
935:Ensembl
874:Species
853:QuickGO
692:nucleus
374:pattern
100:Aliases
2716:Jagged
2709:Ligand
2562:Q04721
2525:
2490:
2455:
2420:
2399:
2391:
2362:
2352:
2319:
2284:
2274:
2241:
2233:
2204:
2197:121486
2194:
2161:
2153:
2118:
2111:191274
2108:
2075:
2045:
2037:
2008:
2000:
1971:
1936:
1928:
1880:
1839:
1798:
1790:
1749:
1739:
1695:
1651:
1643:
1602:
1594:
1558:
1550:
1500:
1492:
1456:
1420:
1297:, and
1279:with:
1253:Notch2
1202:NOTCH2
1148:search
1146:PubMed
1013:O35516
994:Q04721
890:Entrez
545:BioGPS
148:NOTCH2
124:600275
107:NOTCH2
24:NOTCH2
2685:Delta
2397:S2CID
2355:88767
2239:S2CID
2159:S2CID
2043:S2CID
2006:S2CID
1934:S2CID
1796:S2CID
1742:88767
1649:S2CID
1600:S2CID
1556:S2CID
1498:S2CID
1289:GSK3B
1228:notch
923:18129
883:Mouse
878:Human
849:Amigo
519:molar
445:vulva
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
132:97364
2725:JAG2
2720:JAG1
2699:DLL4
2694:DLL3
2689:DLL1
2621:2oo4
2555:for
2523:PMID
2488:PMID
2453:PMID
2418:PMID
2389:PMID
2360:PMID
2317:PMID
2282:PMID
2231:PMID
2202:PMID
2151:PMID
2133:Cell
2116:PMID
2073:PMID
2035:PMID
1998:PMID
1969:PMID
1926:PMID
1878:PMID
1837:PMID
1788:PMID
1770:Cell
1747:PMID
1693:PMID
1641:PMID
1592:PMID
1548:PMID
1490:PMID
1454:PMID
1418:PMID
1301:JAG2
1295:JAG1
1257:PEST
1214:and
1205:gene
904:4853
380:Bgee
328:Band
289:Chr.
232:1p12
227:Band
186:Chr.
140:7865
120:OMIM
77:2OO4
58:RCSB
55:PDBe
2553:PDB
2513:doi
2509:276
2478:doi
2474:276
2443:doi
2439:276
2381:doi
2350:PMC
2342:doi
2307:doi
2303:274
2272:PMC
2264:doi
2260:154
2223:doi
2192:PMC
2184:doi
2141:doi
2106:PMC
2098:doi
2065:doi
2027:doi
1990:doi
1959:doi
1918:doi
1906:284
1868:doi
1864:274
1827:doi
1823:278
1778:doi
1737:PMC
1729:doi
1683:doi
1679:276
1631:doi
1584:doi
1540:doi
1482:doi
1446:doi
1410:doi
1236:EGF
350:End
249:End
152:OMA
128:MGI
48:PDB
2773::
2667::
2559::
2521:.
2507:.
2503:.
2486:.
2472:.
2468:.
2451:.
2437:.
2433:.
2414:61
2412:.
2395:.
2387:.
2377:26
2375:.
2358:.
2348:.
2338:20
2336:.
2332:.
2315:.
2301:.
2297:.
2280:.
2270:.
2258:.
2254:.
2237:.
2229:.
2219:57
2217:.
2200:.
2190:.
2180:18
2178:.
2174:.
2157:.
2149:.
2137:90
2135:.
2131:.
2114:.
2104:.
2094:71
2092:.
2088:.
2071:.
2061:35
2059:.
2041:.
2033:.
2021:.
2004:.
1996:.
1986:46
1984:.
1967:.
1955:29
1953:.
1949:.
1932:.
1924:.
1916:.
1904:.
1876:.
1862:.
1858:.
1835:.
1821:.
1817:.
1794:.
1786:.
1774:90
1772:.
1768:.
1745:.
1735:.
1725:20
1723:.
1719:.
1705:^
1691:.
1677:.
1673:.
1661:^
1647:.
1639:.
1627:32
1625:.
1621:.
1598:.
1590:.
1580:43
1578:.
1554:.
1546:.
1536:43
1534:.
1496:.
1488:.
1478:43
1476:.
1452:.
1442:11
1440:.
1416:.
1406:24
1404:.
1384:.
1366:.
1337:^
1316:^
1267:.
1218:.
1207:.
851:/
356:bp
343:bp
255:bp
242:bp
150:;
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