318:
295:
192:
217:
576:
569:
1209:
324:
223:
1200:, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.
1833:
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cécillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, Cabanis EA, Ruchoux MM, Weissenbach J, Bach JF, Bousser MG, Tournier-Lasserve E (1996). "Notch3 mutations in CADASIL, a hereditary adult-onset
1341:
Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (September 15, 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human
1230:). Mutations in NOTCH3 have also been identified in families with Alzheimer's disease. Adult Notch3 knock-out mice show incomplete neuronal maturation in the spinal cord dorsal horn, resulting in permanently increased nociceptive sensitivity. Mutations in NOTCH3 are associated to
63:
1795:
Tournier-Lasserve E, Joutel A, Melki J, Weissenbach J, Lathrop GM, Chabriat H, Mas JL, Cabanis EA, Baudrimont M, Maciazek J (1993). "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12".
1879:
Joutel A, Vahedi K, Corpechot C, Troesch A, Chabriat H, Vayssière C, Cruaud C, Maciazek J, Weissenbach J, Bousser MG, Bach JF, Tournier-Lasserve E (1997). "Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients".
2040:
Joutel A, Chabriat H, Vahedi K, Domenga V, Vayssière C, Ruchoux MM, Lucas C, Leys D, Bousser MG, Tournier-Lasserve E (2000). "Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL".
2224:"A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings"
1765:
Larsson C, Lardelli M, White I, Lendahl U (1994). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation".
2107:
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (2000). "MAML1, a human homologue of
Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors".
2222:
Oliveri RL, Muglia M, De
Stefano N, Mazzei R, Labate A, Conforti FL, Patitucci A, Gabriele AL, Tagarelli G, Magariello A, Zappia M, Gambardella A, Federico A, Quattrone A (2001).
331:
230:
2333:
1394:
Guerreiro RJ, Lohmann E, Kinsella E, Brás JM, Luu N, Gurunlian N, Dursun B, Bilgic B, Santana I, Hanagasi H, Gurvit H, Gibbs JR, Oliveira C, Emre M, Singleton A (2012).
1226:
Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (
904:
885:
153:
1492:
Gripp KW, Robbins KM, Sobreira NL, Witmer PD, Bird LM, Avela K, Makitie O, Alves D, Hogue JS, Zackai EH, Doheny KF, Stabley DL, Sol-Church K (2014).
2433:
2078:
Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors".
1685:
Guidetti D, Casali B, Mazzei RL, Dotti MT (2006). "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy".
2454:
2326:
1558:
1323:
1242:
Notch3 is being investigated as a target for anti-cancer drugs, as it is overexpressed in several types of cancers. Early clinical trials of
1305:
2003:
Joutel A, Dodick DD, Parisi JE, Cecillon M, Tournier-Lasserve E, Bousser MG (2000). "De novo mutation in the Notch3 gene causing CADASIL".
317:
1104:
1111:
294:
2319:
1917:
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999).
1380:
1396:"Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease"
1292:
1271:
2257:
Dichgans M, Herzog J, Gasser T (2001). "NOTCH3 mutation involving three cysteine residues in a family with typical CADASIL".
216:
191:
2146:"The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity"
2016:
1288:
1960:
Joutel A, Andreux F, Gaulis S, Domenga V, Cecillon M, Battail N, Piga N, Chapon F, Godfrain C, Tournier-Lasserve E (2000).
60:
1267:
1231:
133:
330:
229:
323:
222:
2305:
949:
141:
2354:
2346:
930:
1246:'s PF-06650808, an anti-Notch3 antibody linked to a cytotoxic drug, showed efficacy against solid tumors.
2386:
205:
1962:"The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients"
1843:
120:
2342:
2301:
2282:
2175:
2132:
2066:
2028:
1905:
1867:
1821:
1753:
1710:
1673:
1636:
165:
1087:
1066:
1040:
1019:
575:
568:
2274:
2245:
2210:
2167:
2124:
2095:
2058:
2020:
1991:
1948:
1897:
1859:
1813:
1783:
1745:
1702:
1665:
1628:
1574:
1554:
1523:
1474:
1425:
1359:
113:
53:
2311:
1592:
2266:
2235:
2200:
2157:
2116:
2087:
2050:
2012:
1981:
1973:
1938:
1930:
1889:
1851:
1805:
1775:
1735:
1694:
1657:
1620:
1564:
1546:
1513:
1505:
1464:
1456:
1415:
1407:
1351:
410:
341:
285:
240:
161:
1445:"Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord"
385:
1411:
1847:
1208:
1943:
1918:
1569:
1518:
1493:
1469:
1444:
1420:
1395:
1193:
2162:
2145:
1986:
1961:
1934:
1893:
1624:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
713:
708:
703:
698:
693:
688:
683:
678:
673:
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663:
658:
642:
637:
632:
627:
622:
617:
2448:
1740:
1723:
604:
2286:
2136:
2070:
2032:
1909:
1825:
1757:
1677:
1494:"Truncating mutations in the last exon of NOTCH3 cause lateral meningocele syndrome"
2366:
2179:
1871:
1640:
403:
182:
1714:
1545:. Advances in Experimental Medicine and Biology. Vol. 727. pp. 305–319.
1541:
Purow B (2012). "Notch
Inhibition as a Promising New Approach to Cancer Therapy".
145:
1661:
1550:
169:
1328:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1310:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1220:
2240:
2223:
486:
1698:
1212:
302:
199:
149:
849:
546:
424:
369:
356:
268:
255:
157:
2278:
2249:
2214:
2205:
2188:
2171:
2128:
2099:
2091:
2062:
2024:
1995:
1952:
1779:
1706:
1669:
1578:
1527:
1478:
1429:
1355:
2270:
2054:
1901:
1863:
1817:
1787:
1749:
1632:
1363:
1151:
1146:
1509:
1135:
994:
975:
2428:
2423:
2418:
2189:"Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis"
1809:
1460:
1227:
1216:
1170:
961:
916:
17:
90:
86:
82:
1855:
1243:
1119:
871:
1977:
1593:"Pfizer Oncology: ADC Development Overview (2016) » ADC Review"
2017:
10.1002/1531-8249(200003)47:3<388::AID-ANA19>3.0.CO;2-Q
2120:
1207:
834:
830:
124:, CADASIL, CASIL, IMF2, LMNS, CADASIL1, notch 3, notch receptor 3
2402:
2397:
2376:
2371:
1724:"Comparison of male and female kidney transplant survival rates"
1611:
Lewis J (1996). "Neurogenic genes and vertebrate neurogenesis".
1177:
137:
2315:
584:
2144:
Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (2001).
1188:
This gene encodes the third discovered human homologue of the
810:
positive regulation of transcription of Notch receptor target
795:
positive regulation of transcription by RNA polymerase II
760:
negative regulation of transcription by RNA polymerase II
790:
transcription initiation from RNA polymerase II promoter
393:
800:
positive regulation of smooth muscle cell proliferation
558:
2411:
2385:
2353:
1080:
1059:
1033:
1012:
2187:Saxena MT, Schroeter EH, Mumm JS, Kopan R (2001).
1381:"Entrez Gene: NOTCH3 Notch homolog 3 (Drosophila)"
1284:
1282:
1280:
1263:
1261:
1259:
340:
239:
1342:counterpart of mouse mammary tumor gene int-3".
1289:GRCm38: Ensembl release 89: ENSMUSG00000038146
820:negative regulation of Notch signaling pathway
2327:
745:negative regulation of neuron differentiation
8:
1268:GRCh38: Ensembl release 89: ENSG00000074181
815:Notch receptor processing, ligand-dependent
750:negative regulation of cell differentiation
2334:
2320:
2312:
1722:Beleil OM, Mickey MR, Terasaki PI (1972).
1648:Joutel A, Tournier-Lasserve E (2002). "".
845:
740:regulation of transcription, DNA-templated
600:
381:
280:
177:
71:
2304:at the U.S. National Library of Medicine
2239:
2204:
2161:
1985:
1942:
1739:
1568:
1517:
1468:
1419:
1834:condition causing stroke and dementia".
1543:Notch Signaling in Embryology and Cancer
1375:
1373:
1164:Neurogenic locus notch homolog protein 3
1255:
31:
1919:"Human ligands of the Notch receptor"
345:
306:
301:
244:
203:
198:
7:
1412:10.1016/j.neurobiolaging.2011.10.009
805:regulation of developmental process
1077:
1056:
1030:
1009:
985:
966:
940:
921:
895:
876:
770:multicellular organism development
563:
481:
419:
398:
25:
1173:that in humans is encoded by the
1741:10.1097/00007890-197205000-00008
574:
567:
329:
322:
316:
293:
228:
221:
215:
190:
755:glomerular capillary formation
664:endoplasmic reticulum membrane
659:integral component of membrane
585:More reference expression data
547:More reference expression data
1:
2163:10.1016/S0925-4773(01)00373-2
2080:Biochem. Biophys. Res. Commun
1935:10.1016/S0002-9440(10)65325-4
1894:10.1016/S0140-6736(97)08083-5
1625:10.1016/S0959-4388(96)80002-X
314:
213:
29:Protein-coding gene in humans
2455:Genes on human chromosome 19
1551:10.1007/978-1-4614-0899-4_23
1232:lateral meningocele syndrome
765:transcription, DNA-templated
1443:Rusanescu G, Mao J (2014).
643:signaling receptor activity
471:stromal cell of endometrium
2471:
2412:Receptor on receiving cell
2241:10.1001/archneur.58.9.1418
1662:10.1051/jbio/2002196010109
1699:10.1080/10641960600549223
1324:"Mouse PubMed Reference:"
1306:"Human PubMed Reference:"
1150:
1145:
1141:
1134:
1118:
1099:
1084:
1063:
1052:
1037:
1016:
1005:
992:
988:
973:
969:
960:
947:
943:
928:
924:
915:
902:
898:
883:
879:
870:
855:
848:
844:
828:
638:identical protein binding
603:
599:
582:
566:
557:
544:
493:
484:
451:Descending thoracic aorta
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
79:
74:
57:
52:
47:
43:
39:
34:
2306:Medical Subject Headings
1192:type I membrane protein
1112:Chr 17: 32.34 – 32.39 Mb
2347:notch signaling pathway
1190:Drosophila melanogaster
1105:Chr 19: 15.16 – 15.2 Mb
730:Notch signaling pathway
505:internal carotid artery
497:external carotid artery
2206:10.1074/jbc.M107234200
2092:10.1006/bbrc.2000.3469
1780:10.1006/geno.1994.1613
1356:10.1006/geno.1994.1517
1223:
785:neuron fate commitment
347:17 B1|17 17.37 cM
2302:NOTCH3+protein,+human
2271:10.1212/wnl.57.9.1714
2055:10.1212/wnl.54.9.1874
1613:Curr. Opin. Neurobiol
1238:Pharmaceutical target
1211:
780:forebrain development
443:right coronary artery
308:Chromosome 17 (mouse)
206:Chromosome 19 (human)
1687:Clin. Exp. Hypertens
1510:10.1002/ajmg.a.36863
1498:Am. J. Med. Genet. A
775:artery morphogenesis
735:cell differentiation
694:extracellular region
459:left coronary artery
75:List of PDB id codes
48:Available structures
1848:1996Natur.383..707J
618:calcium ion binding
1810:10.1038/ng0393-256
1461:10.1111/jcmm.12362
1406:(5): 1008.e17–23.
1224:
950:ENSMUSG00000038146
723:Biological process
699:actin cytoskeleton
652:Cellular component
611:Molecular function
170:NOTCH3 - orthologs
2442:
2441:
2357:on signaling cell
2343:Signaling pathway
1560:978-1-4614-0898-7
1449:J. Cell. Mol. Med
1161:
1160:
1157:
1156:
1130:
1129:
1095:
1094:
1074:
1073:
1048:
1047:
1027:
1026:
1001:
1000:
982:
981:
956:
955:
937:
936:
911:
910:
892:
891:
840:
839:
595:
594:
591:
590:
553:
552:
540:
539:
529:lactiferous gland
478:
477:
376:
375:
275:
274:
102:
101:
98:
97:
58:Ortholog search:
16:(Redirected from
2462:
2336:
2329:
2322:
2313:
2290:
2253:
2243:
2218:
2208:
2199:(43): 40268–73.
2183:
2165:
2140:
2103:
2074:
2036:
1999:
1989:
1956:
1946:
1913:
1888:(9090): 1511–5.
1875:
1856:10.1038/383707a0
1842:(6602): 707–10.
1829:
1791:
1761:
1743:
1718:
1681:
1644:
1597:
1596:
1589:
1583:
1582:
1572:
1538:
1532:
1531:
1521:
1489:
1483:
1482:
1472:
1440:
1434:
1433:
1423:
1400:Neurobiol. Aging
1391:
1385:
1384:
1377:
1368:
1367:
1338:
1332:
1331:
1320:
1314:
1313:
1302:
1296:
1286:
1275:
1265:
1143:
1142:
1114:
1107:
1090:
1078:
1069:
1057:
1053:RefSeq (protein)
1043:
1031:
1022:
1010:
986:
967:
941:
922:
896:
877:
846:
679:receptor complex
633:cadherin binding
601:
587:
578:
571:
564:
549:
489:
487:Top expressed in
482:
447:ventricular zone
435:popliteal artery
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
123:
116:
93:
72:
66:
45:
44:
32:
21:
2470:
2469:
2465:
2464:
2463:
2461:
2460:
2459:
2445:
2444:
2443:
2438:
2407:
2381:
2349:
2340:
2298:
2293:
2256:
2221:
2186:
2143:
2106:
2077:
2039:
2002:
1978:10.1172/JCI8047
1966:J. Clin. Invest
1959:
1916:
1878:
1832:
1794:
1764:
1728:Transplantation
1721:
1684:
1647:
1610:
1606:
1604:Further reading
1601:
1600:
1591:
1590:
1586:
1561:
1540:
1539:
1535:
1491:
1490:
1486:
1455:(10): 2103–16.
1442:
1441:
1437:
1393:
1392:
1388:
1379:
1378:
1371:
1340:
1339:
1335:
1322:
1321:
1317:
1304:
1303:
1299:
1287:
1278:
1266:
1257:
1252:
1240:
1219:with a Notch 3
1206:
1186:
1152:View/Edit Mouse
1147:View/Edit Human
1110:
1103:
1100:Location (UCSC)
1086:
1065:
1039:
1018:
931:ENSG00000074181
824:
718:
684:plasma membrane
647:
623:protein binding
583:
573:
572:
545:
536:
531:
527:
523:
519:
515:
511:
507:
503:
499:
485:
474:
469:
465:
461:
457:
455:ascending aorta
453:
449:
445:
441:
439:tibial arteries
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
81:
59:
30:
23:
22:
15:
12:
11:
5:
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2309:
2297:
2296:External links
2294:
2292:
2291:
2254:
2234:(9): 1418–22.
2219:
2184:
2141:
2104:
2075:
2037:
2000:
1972:(5): 597–605.
1957:
1914:
1876:
1830:
1792:
1762:
1734:(5): 493–500.
1719:
1693:(3–4): 271–7.
1682:
1645:
1607:
1605:
1602:
1599:
1598:
1584:
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674:Golgi membrane
671:
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653:
649:
648:
646:
645:
640:
635:
630:
628:enzyme binding
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579:
561:
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541:
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525:left lung lobe
522:
518:
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510:
506:
502:
501:corneal stroma
498:
494:
491:
490:
479:
476:
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468:
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463:saphenous vein
460:
456:
452:
448:
444:
440:
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2467:
2456:
2453:
2452:
2450:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2416:
2414:
2410:
2404:
2401:
2399:
2396:
2393:
2392:
2390:
2388:
2384:
2378:
2375:
2373:
2370:
2368:
2365:
2362:
2361:
2359:
2356:
2352:
2348:
2344:
2337:
2332:
2330:
2325:
2323:
2318:
2317:
2314:
2307:
2303:
2300:
2299:
2295:
2288:
2284:
2280:
2276:
2272:
2268:
2265:(9): 1714–7.
2264:
2260:
2255:
2251:
2247:
2242:
2237:
2233:
2229:
2225:
2220:
2216:
2212:
2207:
2202:
2198:
2194:
2193:J. Biol. Chem
2190:
2185:
2181:
2177:
2173:
2169:
2164:
2159:
2156:(1–2): 3–20.
2155:
2151:
2147:
2142:
2138:
2134:
2130:
2126:
2122:
2121:10.1038/82644
2118:
2114:
2110:
2105:
2101:
2097:
2093:
2089:
2085:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2052:
2049:(9): 1874–5.
2048:
2044:
2038:
2034:
2030:
2026:
2022:
2018:
2014:
2011:(3): 388–91.
2010:
2006:
2001:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1958:
1954:
1950:
1945:
1940:
1936:
1932:
1929:(3): 785–94.
1928:
1924:
1923:Am. J. Pathol
1920:
1915:
1911:
1907:
1903:
1899:
1895:
1891:
1887:
1883:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1763:
1759:
1755:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1656:(1): 109–15.
1655:
1651:
1646:
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1614:
1609:
1608:
1603:
1594:
1588:
1585:
1580:
1576:
1571:
1566:
1562:
1556:
1552:
1548:
1544:
1537:
1534:
1529:
1525:
1520:
1515:
1511:
1507:
1504:(2): 271–81.
1503:
1499:
1495:
1488:
1485:
1480:
1476:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1436:
1431:
1427:
1422:
1417:
1413:
1409:
1405:
1401:
1397:
1390:
1387:
1382:
1376:
1374:
1370:
1365:
1361:
1357:
1353:
1350:(2): 408–19.
1349:
1345:
1337:
1334:
1329:
1325:
1319:
1316:
1311:
1307:
1301:
1298:
1294:
1290:
1285:
1283:
1281:
1277:
1273:
1269:
1264:
1262:
1260:
1256:
1249:
1247:
1245:
1237:
1235:
1233:
1229:
1222:
1218:
1214:
1210:
1203:
1201:
1199:
1195:
1191:
1183:
1181:
1179:
1176:
1172:
1168:
1165:
1153:
1148:
1144:
1140:
1137:
1133:
1126:
1124:
1121:
1117:
1113:
1109:
1106:
1102:
1098:
1091:
1089:
1083:
1079:
1076:
1070:
1068:
1062:
1058:
1055:
1051:
1044:
1042:
1036:
1032:
1029:
1023:
1021:
1015:
1011:
1008:
1006:RefSeq (mRNA)
1004:
997:
996:
991:
987:
984:
978:
977:
972:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
907:
906:
901:
897:
894:
888:
887:
882:
878:
875:
873:
869:
866:
863:
861:
858:
854:
851:
847:
843:
836:
832:
827:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
727:
725:
722:
721:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
656:
654:
651:
650:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
615:
613:
610:
609:
606:
605:Gene ontology
602:
598:
586:
581:
577:
570:
565:
562:
560:
556:
548:
543:
532:
528:
524:
521:Gonadal ridge
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
27:
19:
2262:
2258:
2231:
2228:Arch. Neurol
2227:
2196:
2192:
2153:
2149:
2115:(4): 484–9.
2112:
2108:
2086:(1): 385–9.
2083:
2079:
2046:
2042:
2008:
2004:
1969:
1965:
1926:
1922:
1885:
1881:
1839:
1835:
1804:(3): 256–9.
1801:
1797:
1774:(2): 253–8.
1771:
1767:
1731:
1727:
1690:
1686:
1653:
1650:J. Soc. Biol
1649:
1616:
1612:
1587:
1542:
1536:
1501:
1497:
1487:
1452:
1448:
1438:
1403:
1399:
1389:
1347:
1343:
1336:
1327:
1318:
1309:
1300:
1241:
1225:
1197:
1189:
1187:
1174:
1166:
1163:
1162:
1085:
1064:
1038:
1017:
993:
974:
948:
929:
903:
884:
864:
859:
714:cell surface
533:carotid body
517:vas deferens
409:
402:
129:External IDs
80:
26:
2005:Ann. Neurol
1619:(1): 3–10.
1221:immunostain
689:nucleoplasm
509:ankle joint
467:skin of leg
368:32,385,826
355:32,339,794
267:15,200,995
254:15,159,038
107:Identifiers
2109:Nat. Genet
1798:Nat. Genet
1295:, May 2017
1274:, May 2017
1250:References
1213:Micrograph
1198:Drosophila
413:(ortholog)
150:HomoloGene
2259:Neurology
2150:Mech. Dev
2043:Neurology
1204:Pathology
1167:(Notch 3)
1088:NP_032742
1067:NP_000426
1041:NM_008716
1020:NM_000435
850:Orthologs
158:GeneCards
2449:Category
2355:Receptor
2287:21180235
2279:11706120
2250:11559313
2215:11518718
2172:11404076
2137:23335042
2129:11101851
2100:11006133
2071:19374887
2063:10802807
2033:11532027
2025:10716263
1996:10712431
1953:10079256
1910:38044421
1826:13031278
1768:Genomics
1758:32855236
1707:16833034
1678:86151374
1670:12134625
1579:22399357
1528:25394726
1479:25164209
1430:22153900
1344:Genomics
1291:–
1270:–
1215:showing
1184:Function
1136:Wikidata
829:Sources:
669:membrane
246:19p13.12
2434:Notch 4
2429:Notch 3
2424:Notch 2
2419:Notch 1
2180:9526831
1944:1866435
1902:9388399
1872:4351873
1864:8878478
1844:Bibcode
1818:8485581
1788:7698746
1750:4557798
1641:2921624
1633:8794055
1570:3361718
1519:5589071
1470:4244024
1421:3306507
1364:7835890
1293:Ensembl
1272:Ensembl
1228:CADASIL
1217:CADASIL
1171:protein
962:UniProt
917:Ensembl
856:Species
835:QuickGO
709:cytosol
704:nucleus
388:pattern
114:Aliases
18:Notch 3
2394:Jagged
2387:Ligand
2308:(MeSH)
2285:
2277:
2248:
2213:
2178:
2170:
2135:
2127:
2098:
2069:
2061:
2031:
2023:
1994:
1987:289174
1984:
1951:
1941:
1908:
1900:
1882:Lancet
1870:
1862:
1836:Nature
1824:
1816:
1786:
1756:
1748:
1715:360190
1713:
1705:
1676:
1668:
1639:
1631:
1577:
1567:
1557:
1526:
1516:
1477:
1467:
1428:
1418:
1362:
1244:Pfizer
1175:NOTCH3
1122:search
1120:PubMed
995:Q61982
976:Q9UM47
872:Entrez
559:BioGPS
162:NOTCH3
138:600276
121:NOTCH3
35:NOTCH3
2363:Delta
2283:S2CID
2176:S2CID
2133:S2CID
2067:S2CID
2029:S2CID
1906:S2CID
1868:S2CID
1822:S2CID
1754:S2CID
1711:S2CID
1674:S2CID
1637:S2CID
1196:. In
1194:notch
1169:is a
905:18131
865:Mouse
860:Human
831:Amigo
513:molar
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
146:99460
2403:JAG2
2398:JAG1
2377:DLL4
2372:DLL3
2367:DLL1
2275:PMID
2246:PMID
2211:PMID
2168:PMID
2125:PMID
2096:PMID
2059:PMID
2021:PMID
1992:PMID
1949:PMID
1898:PMID
1860:PMID
1814:PMID
1784:PMID
1746:PMID
1703:PMID
1666:PMID
1629:PMID
1575:PMID
1555:ISBN
1524:PMID
1502:167A
1475:PMID
1426:PMID
1360:PMID
1178:gene
886:4854
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
134:OMIM
91:5CZV
87:5CZX
83:4ZLP
64:RCSB
61:PDBe
2267:doi
2236:doi
2201:doi
2197:276
2158:doi
2154:104
2117:doi
2088:doi
2084:276
2051:doi
2013:doi
1982:PMC
1974:doi
1970:105
1939:PMC
1931:doi
1927:154
1890:doi
1886:350
1852:doi
1840:383
1806:doi
1776:doi
1736:doi
1695:doi
1658:doi
1654:196
1621:doi
1565:PMC
1547:doi
1514:PMC
1506:doi
1465:PMC
1457:doi
1416:PMC
1408:doi
1352:doi
364:End
263:End
166:OMA
154:376
142:MGI
54:PDB
2451::
2345::
2281:.
2273:.
2263:57
2261:.
2244:.
2232:58
2230:.
2226:.
2209:.
2195:.
2191:.
2174:.
2166:.
2152:.
2148:.
2131:.
2123:.
2113:26
2111:.
2094:.
2082:.
2065:.
2057:.
2047:54
2045:.
2027:.
2019:.
2009:47
2007:.
1990:.
1980:.
1968:.
1964:.
1947:.
1937:.
1925:.
1921:.
1904:.
1896:.
1884:.
1866:.
1858:.
1850:.
1838:.
1820:.
1812:.
1800:.
1782:.
1772:24
1770:.
1752:.
1744:.
1732:13
1730:.
1726:.
1709:.
1701:.
1691:28
1689:.
1672:.
1664:.
1652:.
1635:.
1627:.
1615:.
1573:.
1563:.
1553:.
1522:.
1512:.
1500:.
1496:.
1473:.
1463:.
1453:18
1451:.
1447:.
1424:.
1414:.
1404:33
1402:.
1398:.
1372:^
1358:.
1348:23
1346:.
1326:.
1308:.
1279:^
1258:^
1234:.
1180:.
833:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
2335:e
2328:t
2321:v
2289:.
2269::
2252:.
2238::
2217:.
2203::
2182:.
2160::
2139:.
2119::
2102:.
2090::
2073:.
2053::
2035:.
2015::
1998:.
1976::
1955:.
1933::
1912:.
1892::
1874:.
1854::
1846::
1828:.
1808::
1802:3
1790:.
1778::
1760:.
1738::
1717:.
1697::
1680:.
1660::
1643:.
1623::
1617:6
1595:.
1581:.
1549::
1530:.
1508::
1481:.
1459::
1432:.
1410::
1383:.
1366:.
1354::
1330:.
1312:.
288:)
185:)
168::
20:)
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