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Oxysterol

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and cancers. The activities of oxysterols in these diseases could be due to their pro-oxidative and pro-inflammatory activities and their ability to act on cellular organelles (
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of proteins; the mode of action of oxysterols in these effects is still poorly understood. Several oxysterols are associated with age-related diseases such as
393: 106:) that can contribute to activate apoptosis and autophagy. There are arguments supporting that oxysterols have important roles in 121:) to modulate the biogenesis of these molecules and their biological activities is therefore of therapeutic interest. 386: 91: 208: 417: 136: 79: 379: 141: 87: 189: 329: 288: 239: 231: 181: 412: 319: 307: 278: 270: 223: 173: 55: 107: 50:. Such compounds play important roles in various biological processes such as cholesterol 363: 324: 130: 118: 283: 258: 177: 406: 193: 95: 59: 114: 227: 113:
Identifying molecules or mixtures of molecules, developing innovative approaches (
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progression which is involved in several cardiovascular diseases.
39: 162:"A Comprehensive Review on Oxysterols and Related Diseases" 367: 308:"Oxysterols: Friends, Foes, or Just Fellow Passengers?" 312:Arteriosclerosis, Thrombosis, and Vascular Biology 259:"Do oxysterols control cholesterol homeostasis?" 27:Derivative of cholesterol obtained by oxidation 387: 8: 394: 380: 323: 306:Ingemar Björkhem; Ulf Diczfalusy (2002). 282: 152: 263:The Journal of Clinical Investigation 7: 348: 346: 325:10.1161/01.ATV.0000013312.32196.49 25: 178:10.2174/0929867327666200316142659 350: 207:Schroepfer, Gj Jr (Jan 2000). 1: 228:10.1152/physrev.2000.80.1.361 366:. You can help Knowledge by 166:Current Medicinal Chemistry 434: 345: 92:neurodegenerative diseases 257:Björkhem, I (Sep 2002). 160:Samadi, A (Jan 2021). 137:24S-Hydroxycholesterol 133:(5,6-epoxycholesterol) 80:cardiovascular disease 358:This article about a 216:Physiological Reviews 142:27-Hydroxycholesterol 88:macular degeneration 34:is a derivative of 375: 374: 16:(Redirected from 425: 396: 389: 382: 354: 347: 338: 337: 327: 303: 297: 296: 286: 275:10.1172/JCI16388 254: 248: 247: 213: 212:(Free full text) 204: 198: 197: 157: 56:lipid metabolism 21: 433: 432: 428: 427: 426: 424: 423: 422: 403: 402: 401: 400: 343: 341: 305: 304: 300: 256: 255: 251: 211: 206: 205: 201: 159: 158: 154: 150: 127: 108:atherosclerosis 82:, eye disease ( 28: 23: 22: 15: 12: 11: 5: 431: 429: 421: 420: 415: 405: 404: 399: 398: 391: 384: 376: 373: 372: 355: 340: 339: 298: 249: 222:(1): 361–554. 199: 172:(1): 110–136. 151: 149: 146: 145: 144: 139: 134: 131:Oxycholesterol 126: 123: 119:bioremediation 86:, age-related 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 430: 419: 418:Steroid stubs 416: 414: 411: 410: 408: 397: 392: 390: 385: 383: 378: 377: 371: 369: 365: 361: 356: 353: 349: 344: 335: 331: 326: 321: 318:(5): 734–42. 317: 313: 309: 302: 299: 294: 290: 285: 280: 276: 272: 269:(6): 725–30. 268: 264: 260: 253: 250: 245: 241: 237: 233: 229: 225: 221: 217: 210: 203: 200: 195: 191: 187: 183: 179: 175: 171: 167: 163: 156: 153: 147: 143: 140: 138: 135: 132: 129: 128: 124: 122: 120: 116: 111: 109: 105: 101: 97: 93: 89: 85: 81: 77: 73: 69: 65: 61: 60:sphingolipids 57: 53: 49: 45: 41: 37: 33: 19: 368:expanding it 357: 342: 315: 311: 301: 266: 262: 252: 219: 215: 202: 169: 165: 155: 115:gene therapy 112: 96:mitochondria 48:pro-oxidants 38:obtained by 31: 29: 90:), certain 76:prenylation 64:fatty acids 52:homeostasis 36:cholesterol 407:Categories 148:References 100:peroxisome 42:involving 18:Oxysterols 236:0031-9333 194:212729018 72:autophagy 68:apoptosis 46:and / or 40:oxidation 32:oxysterol 334:12006384 293:12235099 244:10617772 186:32175830 104:lysosome 84:cataract 413:Sterols 360:steroid 125:Example 44:enzymes 332:  291:  284:151135 281:  242:  234:  192:  184:  74:, and 362:is a 190:S2CID 364:stub 330:PMID 289:PMID 240:PMID 232:ISSN 182:PMID 320:doi 279:PMC 271:doi 267:110 224:doi 174:doi 66:), 30:An 409:: 328:. 316:22 314:. 310:. 287:. 277:. 265:. 261:. 238:. 230:. 220:80 218:. 214:. 188:. 180:. 170:28 168:. 164:. 117:, 102:, 98:, 70:, 62:, 54:, 395:e 388:t 381:v 370:. 336:. 322:: 295:. 273:: 246:. 226:: 196:. 176:: 58:( 20:)

Index

Oxysterols
cholesterol
oxidation
enzymes
pro-oxidants
homeostasis
lipid metabolism
sphingolipids
fatty acids
apoptosis
autophagy
prenylation
cardiovascular disease
cataract
macular degeneration
neurodegenerative diseases
mitochondria
peroxisome
lysosome
atherosclerosis
gene therapy
bioremediation
Oxycholesterol
24S-Hydroxycholesterol
27-Hydroxycholesterol
"A Comprehensive Review on Oxysterols and Related Diseases"
doi
10.2174/0929867327666200316142659
PMID
32175830

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