318:
295:
3122:
192:
217:
324:
223:
29:
55:
1341:
Kawano T, Indo Y, Nakazato H, Shimadzu M, Matsuda I (June 1998). "Oculocerebrorenal syndrome of Lowe: three mutations in the OCRL1 gene derived from three patients with different phenotypes".
331:
230:
124:, LOCR, NPHL2, OCRL-1, OCRL1, oculocerebrorenal syndrome of Lowe, inositol polyphosphate-5-phosphatase, OCRL inositol polyphosphate-5-phosphatase, INPP5F, Dent-2, DENT2
913:
1748:
Tosetto E, Addis M, Caridi G, et al. (2009). "Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations".
894:
153:
2489:
1787:"Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology"
3163:
2736:
1309:
1705:"Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase"
1820:
Shrimpton AE, Hoopes RR, Knohl SJ, et al. (2009). "OCRL1 mutations in Dent 2 patients suggest a mechanism for phenotypic variability".
1291:
3182:
2650:
2751:
2745:
2546:
2296:
1375:
1354:
1129:
317:
2594:
1917:"Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network"
2705:
2494:
1136:
1666:
Wu F, Reed AA, Williams SE, et al. (2009). "Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease".
294:
1327:
2271:
provides an overview of all the structure information available in the PDB for Human
Inositol polyphosphate 5-phosphatase OCRL-1
2812:
2700:
1278:
1257:
2621:
2531:
2484:
1274:
216:
191:
52:
3043:
2984:
1253:
3088:
2655:
2645:
133:
3187:
3048:
2940:
2565:
1857:
Sekine T, Nozu K, Iyengar R, et al. (2007). "OCRL1 mutations in patients with Dent disease phenotype in Japan".
330:
229:
3156:
2634:
2630:
2626:
2542:
2375:
1225:
1958:
Sethi SK, Bagga A, Gulati A, et al. (2008). "Mutations in OCRL1 gene in Indian children with Lowe syndrome".
2896:
2842:
2802:
2761:
2665:
2504:
2472:
2358:
2322:
323:
222:
2550:
2399:
2313:
2262:
958:
141:
2419:
2289:
939:
2975:
2614:
1213:
This gene encodes an inositol polyphosphate 5-phosphatase. The responsible gene locus is at Xq26.1. This
2253:
3149:
2910:
2807:
2599:
2560:
2424:
2346:
1584:"A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism"
3093:
2928:
2923:
2856:
2516:
2341:
2203:
1458:
205:
120:
2948:
2918:
2722:
2717:
2641:
2577:
2363:
1087:
1036:
2040:"All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding"
3081:
2933:
2414:
2404:
2282:
2258:
1983:
1882:
1845:
1773:
1691:
1654:
165:
1112:
1091:
1083:
1057:
1032:
1028:
2882:
2827:
2795:
2670:
2389:
2231:
2178:
2133:
2112:
2069:
2026:
1975:
1946:
1903:
1874:
1837:
1808:
1765:
1736:
1683:
1646:
1613:
1570:
1527:
1484:
1422:
1358:
1229:
113:
45:
3133:
3121:
2958:
2538:
2443:
2438:
2394:
2221:
2211:
2168:
2158:
2102:
2094:
2059:
2051:
2016:
2008:
1967:
1936:
1928:
1866:
1829:
1798:
1757:
1726:
1716:
1675:
1638:
1627:"Abnormal bradykinin signalling in fibroblasts deficient in the PIP(2) 5-phosphatase, ocrl1"
1603:
1595:
1560:
1552:
1517:
1509:
1474:
1466:
1412:
1404:
1350:
410:
341:
285:
240:
3060:
2874:
2790:
2785:
2780:
2693:
2688:
2448:
2326:
2192:"Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1"
385:
161:
2207:
1462:
1221:
polymerization, and is located in several subcellular parts of the trans-Golgi network.
3033:
3028:
3023:
2409:
2384:
2380:
2353:
2336:
2226:
2191:
2173:
2146:
2107:
2082:
2064:
2039:
2021:
1996:
1941:
1916:
1731:
1704:
1608:
1583:
1565:
1540:
1522:
1497:
1479:
1446:
1417:
1392:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
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747:
742:
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682:
677:
672:
667:
662:
657:
641:
636:
631:
626:
621:
616:
611:
606:
601:
3176:
2774:
2683:
2433:
2268:
2147:"Differential clathrin binding and subcellular localization of OCRL1 splice isoforms"
1541:"Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases"
588:
1886:
1849:
1777:
1695:
1658:
3129:
2901:
2832:
2555:
2476:
1987:
1207:
403:
182:
145:
1498:"A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway"
1513:
169:
3076:
2847:
2741:
2604:
2570:
2508:
2274:
2012:
1314:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1296:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1214:
2055:
486:
3053:
1971:
1870:
1761:
1642:
302:
199:
149:
1556:
2966:
2765:
2678:
2305:
2216:
1932:
858:
546:
424:
369:
356:
268:
255:
157:
2235:
2182:
2163:
2137:
2116:
2073:
2030:
1979:
1950:
1907:
1878:
1841:
1812:
1769:
1740:
1687:
1650:
1617:
1599:
1574:
1531:
1488:
1426:
1355:
10.1002/(SICI)1096-8628(19980605)77:5<348::AID-AJMG2>3.0.CO;2-J
1362:
1176:
1171:
28:
3011:
3006:
3001:
2822:
2457:
2309:
1803:
1786:
1721:
1160:
1003:
984:
1470:
3018:
2996:
2991:
2609:
970:
925:
1833:
1679:
90:
86:
82:
78:
74:
3038:
2971:
2864:
2462:
2370:
1196:
1144:
880:
1626:
2098:
1408:
2980:
2731:
2727:
1218:
1217:
enzyme is in part responsible for regulating membrane trafficking
843:
839:
2712:
2582:
2526:
2521:
1391:
Hoopes RR, Shrimpton AE, Knohl SJ, et al. (February 2005).
1379:
1203:
137:
2278:
2124:
Levtchenko EN, Monnens LA, Bökenkamp A, Knoers NV (2007). "".
637:
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
602:
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
627:
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
2190:
Swan LE, Tomasini L, Pirruccello M, et al. (2010).
2145:
Choudhury R, Noakes CJ, McKenzie E, et al. (2009).
393:
3137:
2081:
Hoopes RR, Shrimpton AE, Knohl SJ, et al. (2005).
2038:
McCrea HJ, Paradise S, Tomasini L, et al. (2008).
1995:
Cui S, Guerriero CJ, Szalinski CM, et al. (2010).
799:
regulation of small GTPase mediated signal transduction
1894:
Chabaâ L, Monnier N, Dahri S, et al. (2006). "".
1785:
Faucherre A, Desbois P, Nagano F, et al. (2005).
1997:"OCRL1 function in renal epithelial membrane traffic"
814:
phosphatidylinositol-3-phosphate biosynthetic process
632:
phosphatidylinositol phosphate 4-phosphatase activity
558:
1703:
Coon BG, Mukherjee D, Hanna CB, et al. (2009).
1445:
Ross MT, Grafham DV, Coffey AJ, et al. (2005).
3069:
2957:
2909:
2895:
2873:
2855:
2841:
2821:
2760:
2664:
2503:
2471:
2321:
1105:
1076:
1050:
1021:
622:
inositol-1,4,5-trisphosphate 5-phosphatase activity
521:
dentate gyrus of hippocampal formation granule cell
1915:Choudhury R, Diao A, Zhang F, et al. (2005).
1539:Hyvola N, Diao A, McKenzie E, et al. (2006).
1496:Erdmann KS, Mao Y, McCrea HJ, et al. (2007).
1270:
1268:
1266:
1249:
1247:
1245:
2600:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1328:"Entrez Gene: oculocerebrorenal syndrome of Lowe"
340:
239:
1582:Mao Y, Balkin DM, Zoncu R, et al. (2009).
16:Protein-coding gene in the species Homo sapiens
2254:GeneReviews/NCBI/NIH/UW entry on Lowe Syndrome
1275:GRCm38: Ensembl release 89: ENSMUSG00000001173
3157:
2290:
8:
1447:"The DNA sequence of the human X chromosome"
1254:GRCh38: Ensembl release 89: ENSG00000122126
1189:Inositol polyphosphate 5-phosphatase OCRL-1
3164:
3150:
2906:
2852:
2838:
2297:
2283:
2275:
854:
584:
381:
280:
177:
63:
2261:at the U.S. National Library of Medicine
2225:
2215:
2172:
2162:
2106:
2063:
2020:
1940:
1802:
1730:
1720:
1625:Suchy SF, Cronin JC, Nussbaum RL (2009).
1607:
1564:
1521:
1478:
1416:
794:phosphatidylinositol biosynthetic process
2490:Ubiquitin carboxy-terminal hydrolase L1
1241:
1193:Lowe oculocerebrorenal syndrome protein
642:inositol phosphate phosphatase activity
2083:"Dent Disease with mutations in OCRL1"
1393:"Dent Disease with mutations in OCRL1"
1224:Deficiencies in OCRL-1 may cause with
809:positive regulation of GTPase activity
789:phosphatidylinositol dephosphorylation
18:
3070:either deoxy- or ribo-
345:
306:
301:
244:
203:
198:
7:
3118:
3116:
2651:Protein serine/threonine phosphatase
829:inositol phosphate dephosphorylation
779:inositol phosphate metabolic process
2752:Cyclic nucleotide phosphodiesterase
2746:Clostridium perfringens alpha toxin
2547:Tartrate-resistant acid phosphatase
1376:Online Mendelian Inheritance in Man
3136:. You can help Knowledge (XXG) by
2595:Pyruvate dehydrogenase phosphatase
1102:
1073:
1047:
1018:
994:
975:
949:
930:
904:
885:
563:
481:
419:
398:
14:
2495:4-hydroxybenzoyl-CoA thioesterase
3120:
329:
322:
316:
293:
228:
221:
215:
190:
27:
2813:N-acetylglucosamine-6-sulfatase
2701:Sphingomyelin phosphodiesterase
2622:Inositol-phosphate phosphatase
2485:Palmitoyl protein thioesterase
774:in utero embryonic development
547:More reference expression data
1:
2985:RNA-induced silencing complex
2044:Biochem. Biophys. Res. Commun
2001:Am. J. Physiol. Renal Physiol
1228:and also have been linked to
769:regulation of GTPase activity
314:
213:
3089:Serratia marcescens nuclease
2656:Dual-specificity phosphatase
2646:Protein tyrosine phosphatase
2196:Proc. Natl. Acad. Sci. U.S.A
1514:10.1016/j.devcel.2007.08.004
784:cell projection organization
3183:Genes on human chromosome X
2566:Fructose 1,6-bisphosphatase
2013:10.1152/ajprenal.00453.2009
748:photoreceptor outer segment
673:phagocytic vesicle membrane
3204:
3115:
2056:10.1016/j.bbrc.2008.02.067
1226:oculocerebrorenal syndrome
2803:Galactosamine-6 sulfatase
2359:6-phosphogluconolactonase
1972:10.1007/s10157-008-0059-0
1871:10.1007/s00467-007-0454-x
1762:10.1007/s00467-009-1228-4
1643:10.1007/s10545-009-1058-3
1310:"Mouse PubMed Reference:"
1292:"Human PubMed Reference:"
1175:
1170:
1166:
1159:
1143:
1130:Chr X: 129.54 – 129.59 Mb
1124:
1109:
1080:
1069:
1054:
1025:
1014:
1001:
997:
982:
978:
969:
956:
952:
937:
933:
924:
911:
907:
892:
888:
879:
864:
857:
853:
837:
617:GTPase activator activity
587:
583:
571:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
2551:Purple acid phosphatases
2263:Medical Subject Headings
1896:Ann. Biol. Clin. (Paris)
1557:10.1038/sj.emboj.7601274
708:Golgi-associated vesicle
2217:10.1073/pnas.0914658107
1933:10.1091/mbc.E05-02-0120
1137:Chr X: 47.91 – 47.97 Mb
743:clathrin-coated vesicle
688:early endosome membrane
2976:Microprocessor complex
2615:Beta-propeller phytase
2164:10.1074/jbc.M807442200
1631:J. Inherit. Metab. Dis
1600:10.1038/emboj.2009.155
513:superior frontal gyrus
2911:Endodeoxyribonuclease
2808:Iduronate-2-sulfatase
2561:Glucose 6-phosphatase
2347:Butyrylcholinesterase
2126:Ned Tijdschr Geneeskd
824:membrane organization
509:primary visual cortex
3094:Micrococcal nuclease
2929:Deoxyribonuclease IV
2924:Deoxyribonuclease II
2857:Exodeoxyribonuclease
2517:Alkaline phosphatase
2342:Acetylcholinesterase
525:ventromedial nucleus
455:right adrenal cortex
308:X chromosome (mouse)
206:X chromosome (human)
67:List of PDB id codes
40:Available structures
2949:UvrABC endonuclease
2919:Deoxyribonuclease I
2642:Protein phosphatase
2578:Protein phosphatase
2376:Bile salt-dependent
2364:PAF acetylhydrolase
2259:OCRL+protein,+human
2208:2010PNAS..107.3511S
1471:10.1038/nature03440
1463:2005Natur.434..325R
804:signal transduction
733:cytoplasmic vesicle
728:clathrin-coated pit
713:trans-Golgi network
467:left adrenal cortex
447:islet of Langerhans
3188:Biochemistry stubs
3082:Mung bean nuclease
2941:Restriction enzyme
2934:Restriction enzyme
1960:Clin. Exp. Nephrol
1804:10.1093/hmg/ddi153
1722:10.1093/hmg/ddp407
959:ENSMUSG00000001173
757:Biological process
651:Cellular component
612:hydrolase activity
595:Molecular function
463:left adrenal gland
459:anterior pituitary
3145:
3144:
3110:
3109:
3106:
3105:
3102:
3101:
2891:
2890:
2883:Oligonucleotidase
2828:deoxyribonuclease
2796:Steroid sulfatase
2671:Phosphodiesterase
2400:Hormone-sensitive
2087:Am. J. Hum. Genet
1834:10.1159/000213506
1680:10.1159/000225944
1397:Am. J. Hum. Genet
1343:Am. J. Med. Genet
1186:
1185:
1182:
1181:
1155:
1154:
1120:
1119:
1099:
1098:
1065:
1064:
1044:
1043:
1010:
1009:
991:
990:
965:
964:
946:
945:
920:
919:
901:
900:
849:
848:
579:
578:
575:
574:
553:
552:
540:
539:
478:
477:
376:
375:
275:
274:
102:
101:
98:
97:
50:Ortholog search:
3195:
3166:
3159:
3152:
3124:
3117:
2959:Endoribonuclease
2945:
2939:
2907:
2853:
2839:
2539:Acid phosphatase
2420:Monoacylglycerol
2330:ester hydrolases
2299:
2292:
2285:
2276:
2239:
2229:
2219:
2186:
2176:
2166:
2141:
2120:
2110:
2077:
2067:
2034:
2024:
1991:
1954:
1944:
1911:
1890:
1859:Pediatr. Nephrol
1853:
1816:
1806:
1781:
1750:Pediatr. Nephrol
1744:
1734:
1724:
1699:
1662:
1621:
1611:
1578:
1568:
1535:
1525:
1492:
1482:
1457:(7031): 325–37.
1431:
1430:
1420:
1388:
1382:
1373:
1367:
1366:
1338:
1332:
1331:
1324:
1318:
1317:
1306:
1300:
1299:
1288:
1282:
1272:
1261:
1251:
1191:, also known as
1168:
1167:
1139:
1132:
1115:
1103:
1094:
1074:
1070:RefSeq (protein)
1060:
1048:
1039:
1019:
995:
976:
950:
931:
905:
886:
855:
764:lipid metabolism
585:
564:
549:
529:genital tubercle
489:
487:Top expressed in
482:
435:Brodmann area 10
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
170:OCRL - orthologs
123:
116:
93:
64:
58:
37:
36:
31:
19:
3203:
3202:
3198:
3197:
3196:
3194:
3193:
3192:
3173:
3172:
3171:
3170:
3113:
3111:
3098:
3065:
2953:
2943:
2937:
2900:
2887:
2875:Exoribonuclease
2869:
2846:
2830:
2826:
2817:
2791:Arylsulfatase L
2786:Arylsulfatase B
2781:Arylsulfatase A
2756:
2669:
2660:
2499:
2467:
2329:
2317:
2303:
2250:
2244:
2242:
2189:
2157:(15): 9965–73.
2144:
2132:(43): 2377–80.
2123:
2080:
2037:
1994:
1957:
1921:Mol. Biol. Cell
1914:
1893:
1856:
1822:Nephron Physiol
1819:
1791:Hum. Mol. Genet
1784:
1756:(10): 1967–73.
1747:
1715:(23): 4478–91.
1709:Hum. Mol. Genet
1702:
1668:Nephron Physiol
1665:
1624:
1594:(13): 1831–42.
1581:
1551:(16): 3750–61.
1538:
1495:
1444:
1440:
1438:Further reading
1435:
1434:
1390:
1389:
1385:
1374:
1370:
1340:
1339:
1335:
1326:
1325:
1321:
1308:
1307:
1303:
1290:
1289:
1285:
1273:
1264:
1252:
1243:
1238:
1206:located on the
1199:encoded by the
1177:View/Edit Mouse
1172:View/Edit Human
1135:
1128:
1125:Location (UCSC)
1111:
1090:
1086:
1082:
1056:
1035:
1031:
1027:
940:ENSG00000122126
833:
819:cilium assembly
752:
698:plasma membrane
683:cell projection
678:Golgi apparatus
646:
607:protein binding
545:
536:
531:
527:
523:
519:
517:muscle of thigh
515:
511:
507:
503:
499:
485:
474:
469:
465:
461:
457:
453:
449:
445:
441:
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
73:
51:
17:
12:
11:
5:
3201:
3199:
3191:
3190:
3185:
3175:
3174:
3169:
3168:
3161:
3154:
3146:
3143:
3142:
3125:
3108:
3107:
3104:
3103:
3100:
3099:
3097:
3096:
3091:
3086:
3085:
3084:
3073:
3071:
3067:
3066:
3064:
3063:
3058:
3057:
3056:
3051:
3046:
3041:
3031:
3026:
3021:
3016:
3015:
3014:
3009:
3004:
2999:
2989:
2988:
2987:
2978:
2963:
2961:
2955:
2954:
2952:
2951:
2946:
2931:
2926:
2921:
2915:
2913:
2904:
2893:
2892:
2889:
2888:
2886:
2885:
2879:
2877:
2871:
2870:
2868:
2867:
2861:
2859:
2850:
2836:
2819:
2818:
2816:
2815:
2810:
2805:
2800:
2799:
2798:
2793:
2788:
2783:
2770:
2768:
2758:
2757:
2755:
2754:
2749:
2739:
2734:
2725:
2720:
2715:
2710:
2709:
2708:
2698:
2697:
2696:
2691:
2681:
2675:
2673:
2662:
2661:
2659:
2658:
2653:
2648:
2639:
2638:
2637:
2619:
2618:
2617:
2607:
2602:
2597:
2592:
2587:
2586:
2585:
2575:
2574:
2573:
2563:
2558:
2553:
2536:
2535:
2534:
2529:
2524:
2513:
2511:
2501:
2500:
2498:
2497:
2492:
2487:
2481:
2479:
2469:
2468:
2466:
2465:
2460:
2454:
2453:
2452:
2451:
2446:
2441:
2430:
2429:
2428:
2427:
2425:Diacylglycerol
2422:
2417:
2412:
2407:
2402:
2397:
2392:
2387:
2378:
2367:
2366:
2361:
2356:
2354:Pectinesterase
2351:
2350:
2349:
2344:
2337:Cholinesterase
2333:
2331:
2319:
2318:
2304:
2302:
2301:
2294:
2287:
2279:
2273:
2272:
2266:
2256:
2249:
2248:External links
2246:
2241:
2240:
2187:
2142:
2121:
2099:10.1086/427887
2078:
2035:
2007:(2): F335-45.
1992:
1955:
1927:(8): 3467–79.
1912:
1891:
1854:
1817:
1797:(11): 1441–8.
1782:
1745:
1700:
1663:
1622:
1579:
1536:
1493:
1441:
1439:
1436:
1433:
1432:
1409:10.1086/427887
1383:
1368:
1333:
1319:
1301:
1283:
1262:
1240:
1239:
1237:
1234:
1230:Dent's disease
1184:
1183:
1180:
1179:
1174:
1164:
1163:
1157:
1156:
1153:
1152:
1150:
1148:
1141:
1140:
1133:
1126:
1122:
1121:
1118:
1117:
1107:
1106:
1100:
1097:
1096:
1078:
1077:
1071:
1067:
1066:
1063:
1062:
1052:
1051:
1045:
1042:
1041:
1023:
1022:
1016:
1012:
1011:
1008:
1007:
999:
998:
992:
989:
988:
980:
979:
973:
967:
966:
963:
962:
954:
953:
947:
944:
943:
935:
934:
928:
922:
921:
918:
917:
909:
908:
902:
899:
898:
890:
889:
883:
877:
876:
871:
866:
862:
861:
851:
850:
847:
846:
835:
834:
832:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
760:
758:
754:
753:
751:
750:
745:
740:
735:
730:
725:
720:
718:early endosome
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
654:
652:
648:
647:
645:
644:
639:
634:
629:
624:
619:
614:
609:
604:
598:
596:
592:
591:
581:
580:
577:
576:
573:
572:
569:
568:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
510:
506:
505:tail of embryo
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
468:
464:
460:
456:
452:
448:
444:
440:
439:gastric mucosa
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3200:
3189:
3186:
3184:
3181:
3180:
3178:
3167:
3162:
3160:
3155:
3153:
3148:
3147:
3141:
3139:
3135:
3132:article is a
3131:
3126:
3123:
3119:
3114:
3095:
3092:
3090:
3087:
3083:
3080:
3079:
3078:
3075:
3074:
3072:
3068:
3062:
3059:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3036:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2994:
2993:
2990:
2986:
2982:
2979:
2977:
2973:
2970:
2969:
2968:
2965:
2964:
2962:
2960:
2956:
2950:
2947:
2942:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2916:
2914:
2912:
2908:
2905:
2903:
2898:
2894:
2884:
2881:
2880:
2878:
2876:
2872:
2866:
2863:
2862:
2860:
2858:
2854:
2851:
2849:
2844:
2840:
2837:
2834:
2829:
2824:
2820:
2814:
2811:
2809:
2806:
2804:
2801:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2778:
2777:
2776:
2775:arylsulfatase
2772:
2771:
2769:
2767:
2763:
2759:
2753:
2750:
2747:
2743:
2740:
2738:
2735:
2733:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2707:
2704:
2703:
2702:
2699:
2695:
2692:
2690:
2687:
2686:
2685:
2684:Phospholipase
2682:
2680:
2677:
2676:
2674:
2672:
2667:
2663:
2657:
2654:
2652:
2649:
2647:
2643:
2640:
2636:
2632:
2628:
2625:
2624:
2623:
2620:
2616:
2613:
2612:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2584:
2581:
2580:
2579:
2576:
2572:
2569:
2568:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2548:
2544:
2540:
2537:
2533:
2530:
2528:
2525:
2523:
2520:
2519:
2518:
2515:
2514:
2512:
2510:
2506:
2502:
2496:
2493:
2491:
2488:
2486:
2483:
2482:
2480:
2478:
2474:
2470:
2464:
2461:
2459:
2456:
2455:
2450:
2447:
2445:
2442:
2440:
2437:
2436:
2435:
2434:Phospholipase
2432:
2431:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2382:
2379:
2377:
2374:
2373:
2372:
2369:
2368:
2365:
2362:
2360:
2357:
2355:
2352:
2348:
2345:
2343:
2340:
2339:
2338:
2335:
2334:
2332:
2328:
2324:
2320:
2315:
2311:
2307:
2300:
2295:
2293:
2288:
2286:
2281:
2280:
2277:
2270:
2267:
2264:
2260:
2257:
2255:
2252:
2251:
2247:
2245:
2237:
2233:
2228:
2223:
2218:
2213:
2209:
2205:
2202:(8): 3511–6.
2201:
2197:
2193:
2188:
2184:
2180:
2175:
2170:
2165:
2160:
2156:
2152:
2151:J. Biol. Chem
2148:
2143:
2139:
2135:
2131:
2127:
2122:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2088:
2084:
2079:
2075:
2071:
2066:
2061:
2057:
2053:
2049:
2045:
2041:
2036:
2032:
2028:
2023:
2018:
2014:
2010:
2006:
2002:
1998:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1966:(5): 358–62.
1965:
1961:
1956:
1952:
1948:
1943:
1938:
1934:
1930:
1926:
1922:
1918:
1913:
1909:
1905:
1901:
1897:
1892:
1888:
1884:
1880:
1876:
1872:
1868:
1865:(7): 975–80.
1864:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1823:
1818:
1814:
1810:
1805:
1800:
1796:
1792:
1788:
1783:
1779:
1775:
1771:
1767:
1763:
1759:
1755:
1751:
1746:
1742:
1738:
1733:
1728:
1723:
1718:
1714:
1710:
1706:
1701:
1697:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1664:
1660:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1623:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1580:
1576:
1572:
1567:
1562:
1558:
1554:
1550:
1546:
1542:
1537:
1533:
1529:
1524:
1519:
1515:
1511:
1508:(3): 377–90.
1507:
1503:
1499:
1494:
1490:
1486:
1481:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1443:
1442:
1437:
1428:
1424:
1419:
1414:
1410:
1406:
1402:
1398:
1394:
1387:
1384:
1381:
1377:
1372:
1369:
1364:
1360:
1356:
1352:
1349:(5): 348–55.
1348:
1344:
1337:
1334:
1329:
1323:
1320:
1315:
1311:
1305:
1302:
1297:
1293:
1287:
1284:
1280:
1276:
1271:
1269:
1267:
1263:
1259:
1255:
1250:
1248:
1246:
1242:
1235:
1233:
1231:
1227:
1222:
1220:
1216:
1211:
1209:
1205:
1202:
1198:
1194:
1190:
1178:
1173:
1169:
1165:
1162:
1158:
1151:
1149:
1146:
1142:
1138:
1134:
1131:
1127:
1123:
1116:
1114:
1108:
1104:
1101:
1095:
1093:
1089:
1085:
1079:
1075:
1072:
1068:
1061:
1059:
1053:
1049:
1046:
1040:
1038:
1034:
1030:
1024:
1020:
1017:
1015:RefSeq (mRNA)
1013:
1006:
1005:
1000:
996:
993:
987:
986:
981:
977:
974:
972:
968:
961:
960:
955:
951:
948:
942:
941:
936:
932:
929:
927:
923:
916:
915:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
875:
872:
870:
867:
863:
860:
856:
852:
845:
841:
836:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
761:
759:
756:
755:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
590:
589:Gene ontology
586:
582:
570:
565:
562:
560:
556:
548:
543:
533:adrenal gland
532:
528:
524:
520:
516:
512:
508:
504:
500:
497:otolith organ
496:
495:
492:
488:
483:
480:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
395:
391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3138:expanding it
3130:biochemistry
3127:
3112:
2944:}}
2938:{{
2902:Endonuclease
2833:ribonuclease
2773:
2589:
2556:Nucleotidase
2477:Thioesterase
2243:
2199:
2195:
2154:
2150:
2129:
2125:
2093:(2): 260–7.
2090:
2086:
2050:(2): 493–9.
2047:
2043:
2004:
2000:
1963:
1959:
1924:
1920:
1899:
1895:
1862:
1858:
1828:(2): 27–36.
1825:
1821:
1794:
1790:
1753:
1749:
1712:
1708:
1674:(4): 53–62.
1671:
1667:
1637:(2): 280–8.
1634:
1630:
1591:
1587:
1548:
1544:
1505:
1501:
1454:
1450:
1403:(2): 260–7.
1400:
1396:
1386:
1371:
1346:
1342:
1336:
1322:
1313:
1304:
1295:
1286:
1223:
1212:
1208:X chromosome
1200:
1192:
1188:
1187:
1110:
1088:NP_001305713
1081:
1055:
1037:NM_001318784
1026:
1002:
983:
957:
938:
912:
893:
873:
868:
471:right testis
443:frontal pole
409:
402:
267:129,592,561
254:129,539,849
129:External IDs
72:
3077:Nuclease S1
2848:Exonuclease
2742:Lecithinase
2571:Calcineurin
2509:Phosphatase
2415:Lipoprotein
2405:Endothelial
1902:(1): 53–9.
1215:phosphatase
1210:in humans.
723:Golgi stack
368:47,965,868
355:47,912,387
347:X|X A5
107:Identifiers
3177:Categories
2390:Pancreatic
2327:Carboxylic
1281:, May 2017
1260:, May 2017
1236:References
451:left ovary
413:(ortholog)
150:HomoloGene
2967:RNase III
2825:(includes
2766:Sulfatase
2679:Autotaxin
2543:Prostatic
2395:Lysosomal
2310:esterases
2306:Hydrolase
1502:Dev. Cell
1113:NP_796189
1092:NP_001578
1084:NP_000267
1058:NM_177215
1033:NM_001587
1029:NM_000276
859:Orthologs
658:cytoplasm
158:GeneCards
3061:RNase T1
2823:Nuclease
2458:Cutinase
2236:20133602
2183:19211563
2138:18019214
2117:15627218
2074:18307981
2031:19940034
1980:18500547
1951:15917292
1908:16420990
1887:20047399
1879:17384968
1850:21834343
1842:19390221
1813:15829501
1778:25741167
1770:19582483
1741:19700499
1696:24946606
1688:19546591
1659:31583330
1651:19172411
1618:19536138
1575:16902405
1532:17765681
1489:15772651
1427:15627218
1378:(OMIM):
1277:–
1256:–
1195:, is an
1161:Wikidata
838:Sources:
693:membrane
668:endosome
3034:RNase E
3029:RNase Z
3024:RNase A
3019:RNase P
2992:RNase H
2610:Phytase
2410:Hepatic
2385:Lingual
2381:Gastric
2269:PDBe-KB
2227:2840420
2204:Bibcode
2174:2665120
2108:1196371
2065:2442618
2022:2822509
1988:3458176
1942:1182289
1732:7289333
1609:2711190
1566:1553191
1523:2025683
1480:2665286
1459:Bibcode
1418:1196371
1363:9632163
1279:Ensembl
1258:Ensembl
971:UniProt
926:Ensembl
865:Species
844:QuickGO
738:nucleus
663:cytosol
501:utricle
388:pattern
114:Aliases
2972:Drosha
2897:3.1.21
2865:RecBCD
2843:3.1.11
2463:PETase
2371:Lipase
2265:(MeSH)
2234:
2224:
2181:
2171:
2136:
2115:
2105:
2072:
2062:
2029:
2019:
1986:
1978:
1949:
1939:
1906:
1885:
1877:
1848:
1840:
1811:
1776:
1768:
1739:
1729:
1694:
1686:
1657:
1649:
1616:
1606:
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