321:
298:
195:
220:
586:
579:
572:
327:
226:
1890:
50:
1333:
Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM (March 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination".
1149:
gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.
1368:
Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL".
334:
233:
1445:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1505:"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"
844:
156:
825:
1137:
from branched poly-ubiquitin chains, being specific for lysine -linked polyubiquitin but not lysine -linked polyubiquitin. It interacts with another
1474:
Makarova KS, Aravind L, Koonin EV (2000). "A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and
Chlamydia pneumoniae".
1959:
1935:
1246:
1954:
1228:
1416:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
320:
1044:
297:
1792:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1051:
1316:
1839:"Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry"
1215:
1194:
219:
194:
1211:
47:
1190:
136:
1158:
333:
232:
1928:
1634:
Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL".
326:
225:
889:
144:
1751:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1138:
870:
1921:
208:
1801:
1594:
123:
1548:"Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family"
1868:
1825:
1659:
1393:
168:
1583:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1027:
1006:
980:
959:
1860:
1817:
1780:
1737:
1694:
1651:
1622:
1569:
1534:
1491:
1462:
1433:
1385:
1350:
1295:
585:
578:
116:
40:
1905:
1850:
1809:
1770:
1762:
1727:
1719:
1684:
1643:
1612:
1602:
1559:
1524:
1516:
1483:
1454:
1425:
1377:
1342:
1285:
1277:
1142:
413:
344:
288:
243:
164:
571:
388:
1133:
proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves
1805:
1598:
1290:
1265:
1775:
1750:
1732:
1707:
1617:
1582:
1564:
1547:
1529:
1504:
1487:
1458:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
698:
693:
688:
683:
678:
662:
657:
652:
647:
642:
637:
632:
627:
1948:
1901:
1429:
614:
1872:
1663:
1397:
148:
1829:
406:
185:
1855:
1838:
172:
1251:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1233:
National Center for
Biotechnology Information, U.S. National Library of Medicine
489:
1281:
305:
202:
152:
1673:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1134:
789:
549:
427:
372:
359:
271:
258:
160:
1864:
1821:
1784:
1741:
1698:
1655:
1626:
1607:
1573:
1538:
1495:
1389:
1354:
1299:
1466:
1437:
1129:
Otubain-1 is a member of the OTU (ovarian tumor) superfamily of predicted
1091:
1086:
1146:
1130:
1075:
934:
915:
1813:
1766:
1723:
1346:
1266:"Otubains: a new family of cysteine proteases in the ubiquitin pathway"
901:
856:
127:, OTB1, OTU1, HSPC263, OTU deubiquitinase, ubiquitin aldehyde binding 1
1520:
93:
89:
85:
81:
77:
73:
69:
1166:
1162:
1111:
1059:
811:
1889:
1689:
1672:
1647:
1381:
1264:
Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003).
774:
770:
1897:
1121:. Alternative splicing results in multiple transcript variants.
1118:
594:
140:
1317:"Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1"
1708:"Functional proteomics mapping of a human signaling pathway"
745:
negative regulation of histone H2A K63-linked ubiquitination
1581:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
396:
1909:
1749:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
561:
1706:Colland F, Jacq X, Trouplin V, et al. (2004).
1546:Borodovsky A, Ovaa H, Kolli N, et al. (2003).
1020:
999:
973:
952:
500:
dentate gyrus of hippocampal formation granule cell
1671:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1207:
1205:
1203:
1186:
1184:
1182:
740:negative regulation of double-strand break repair
343:
242:
1837:Juris SJ, Shah K, Shokat K, et al. (2006).
16:Protein-coding gene in the species Homo sapiens
1328:
1326:
1212:GRCm38: Ensembl release 89: ENSMUSG00000024767
1929:
8:
1503:Zhang QH, Ye M, Wu XY, et al. (2001).
1191:GRCh38: Ensembl release 89: ENSG00000167770
1936:
1922:
785:
610:
384:
283:
180:
58:
1854:
1774:
1731:
1688:
1616:
1606:
1563:
1528:
1289:
1311:
1309:
735:cellular response to DNA damage stimulus
1178:
18:
348:
309:
304:
247:
206:
201:
7:
1886:
1884:
720:protein K48-linked deubiquitination
1908:. You can help Knowledge (XXG) by
1017:
996:
970:
949:
925:
906:
880:
861:
835:
816:
750:cellular response to interleukin-1
566:
484:
422:
401:
14:
1114:that in humans is encoded by the
1888:
663:ubiquitin protein ligase binding
633:NEDD8-specific protease activity
628:cysteine-type peptidase activity
584:
577:
570:
332:
325:
319:
296:
231:
224:
218:
193:
1960:Human chromosome 11 gene stubs
638:thiol-dependent deubiquitinase
595:More reference expression data
550:More reference expression data
446:right hemisphere of cerebellum
1:
1856:10.1016/j.febslet.2005.11.071
1565:10.1016/S1074-5521(02)00248-X
1488:10.1016/S0968-0004(99)01530-3
1459:10.1016/S0378-1119(97)00411-3
317:
216:
1955:Genes on human chromosome 11
1587:Proc. Natl. Acad. Sci. U.S.A
1430:10.1016/0378-1119(94)90802-8
1104:Ubiquitin thioesterase OTUB1
1976:
1883:
1282:10.1038/sj.embor.embor824
1247:"Mouse PubMed Reference:"
1229:"Human PubMed Reference:"
1090:
1085:
1081:
1074:
1058:
1039:
1024:
1003:
992:
977:
956:
945:
932:
928:
913:
909:
900:
887:
883:
868:
864:
855:
842:
838:
823:
819:
810:
795:
788:
784:
768:
613:
609:
592:
569:
560:
547:
496:
487:
458:anterior cingulate cortex
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
66:
61:
44:
39:
34:
30:
26:
21:
1157:OTUB1 has been shown to
760:protein deubiquitination
715:adaptive immune response
1608:10.1073/pnas.242603899
1052:Chr 19: 7.18 – 7.18 Mb
516:neural layer of retina
504:superior frontal gyrus
466:pancreatic ductal cell
1045:Chr 11: 63.99 – 64 Mb
725:immune system process
684:extracellular exosome
532:primary visual cortex
311:Chromosome 19 (mouse)
209:Chromosome 11 (human)
62:List of PDB id codes
35:Available structures
1814:10.1038/nature04209
1806:2005Natur.437.1173R
1599:2002PNAS...9916899M
1476:Trends Biochem. Sci
1896:This article on a
1767:10.1101/gr.2596504
1724:10.1101/gr.2334104
1347:10.1042/BJ20081318
1139:ubiquitin protease
890:ENSMUSG00000024767
708:Biological process
672:Cellular component
658:hydrolase activity
643:peptidase activity
621:Molecular function
438:right frontal lobe
1917:
1916:
1593:(26): 16899–903.
1521:10.1101/gr.140200
1101:
1100:
1097:
1096:
1070:
1069:
1035:
1034:
1014:
1013:
988:
987:
967:
966:
941:
940:
922:
921:
896:
895:
877:
876:
851:
850:
832:
831:
780:
779:
648:ubiquitin binding
605:
604:
601:
600:
556:
555:
543:
542:
481:
480:
442:prefrontal cortex
379:
378:
278:
277:
173:OTUB1 - orthologs
105:
104:
101:
100:
45:Ortholog search:
1967:
1938:
1931:
1924:
1892:
1885:
1876:
1858:
1833:
1800:(7062): 1173–8.
1788:
1778:
1745:
1735:
1702:
1692:
1667:
1630:
1620:
1610:
1577:
1567:
1542:
1532:
1499:
1470:
1441:
1402:
1401:
1365:
1359:
1358:
1330:
1321:
1320:
1313:
1304:
1303:
1293:
1261:
1255:
1254:
1243:
1237:
1236:
1225:
1219:
1209:
1198:
1188:
1143:ubiquitin ligase
1083:
1082:
1054:
1047:
1030:
1018:
1009:
997:
993:RefSeq (protein)
983:
971:
962:
950:
926:
907:
881:
862:
836:
817:
786:
611:
597:
588:
581:
574:
567:
552:
512:ventricular zone
492:
490:Top expressed in
485:
450:Brodmann area 10
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
59:
53:
32:
31:
19:
1975:
1974:
1970:
1969:
1968:
1966:
1965:
1964:
1945:
1944:
1943:
1942:
1881:
1879:
1836:
1791:
1761:(10B): 2121–7.
1748:
1705:
1670:
1633:
1580:
1558:(10): 1149–59.
1545:
1515:(10): 1546–60.
1502:
1473:
1453:(1–2): 149–56.
1444:
1415:
1411:
1409:Further reading
1406:
1405:
1367:
1366:
1362:
1332:
1331:
1324:
1315:
1314:
1307:
1263:
1262:
1258:
1245:
1244:
1240:
1227:
1226:
1222:
1210:
1201:
1189:
1180:
1175:
1155:
1127:
1092:View/Edit Mouse
1087:View/Edit Human
1050:
1043:
1040:Location (UCSC)
1026:
1005:
979:
958:
871:ENSG00000167770
764:
703:
667:
653:protein binding
593:
583:
582:
576:
575:
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
474:Brodmann area 9
472:
470:mucosa of ileum
468:
464:
460:
456:
454:cingulate gyrus
452:
448:
444:
440:
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
68:
46:
17:
12:
11:
5:
1973:
1971:
1963:
1962:
1957:
1947:
1946:
1941:
1940:
1933:
1926:
1918:
1915:
1914:
1893:
1878:
1877:
1834:
1789:
1746:
1718:(7): 1324–32.
1703:
1690:10.1038/ng1285
1668:
1648:10.1038/ni1017
1631:
1578:
1543:
1500:
1471:
1442:
1424:(1–2): 171–4.
1412:
1410:
1407:
1404:
1403:
1382:10.1038/ni1017
1360:
1322:
1305:
1256:
1238:
1220:
1199:
1177:
1176:
1174:
1171:
1154:
1151:
1145:that inhibits
1126:
1123:
1106:also known as
1099:
1098:
1095:
1094:
1089:
1079:
1078:
1072:
1071:
1068:
1067:
1065:
1063:
1056:
1055:
1048:
1041:
1037:
1036:
1033:
1032:
1022:
1021:
1015:
1012:
1011:
1001:
1000:
994:
990:
989:
986:
985:
975:
974:
968:
965:
964:
954:
953:
947:
943:
942:
939:
938:
930:
929:
923:
920:
919:
911:
910:
904:
898:
897:
894:
893:
885:
884:
878:
875:
874:
866:
865:
859:
853:
852:
849:
848:
840:
839:
833:
830:
829:
821:
820:
814:
808:
807:
802:
797:
793:
792:
782:
781:
778:
777:
766:
765:
763:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
711:
709:
705:
704:
702:
701:
696:
691:
686:
681:
675:
673:
669:
668:
666:
665:
660:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
607:
606:
603:
602:
599:
598:
590:
589:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
533:
529:
525:
524:tail of embryo
521:
517:
513:
509:
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1972:
1961:
1958:
1956:
1953:
1952:
1950:
1939:
1934:
1932:
1927:
1925:
1920:
1919:
1913:
1911:
1907:
1903:
1902:chromosome 11
1899:
1894:
1891:
1887:
1882:
1874:
1870:
1866:
1862:
1857:
1852:
1849:(1): 179–83.
1848:
1844:
1840:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1790:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1747:
1743:
1739:
1734:
1729:
1725:
1721:
1717:
1713:
1709:
1704:
1700:
1696:
1691:
1686:
1682:
1678:
1674:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1637:
1632:
1628:
1624:
1619:
1614:
1609:
1604:
1600:
1596:
1592:
1588:
1584:
1579:
1575:
1571:
1566:
1561:
1557:
1553:
1549:
1544:
1540:
1536:
1531:
1526:
1522:
1518:
1514:
1510:
1506:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1414:
1413:
1408:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1364:
1361:
1356:
1352:
1348:
1344:
1341:(2): 379–90.
1340:
1336:
1329:
1327:
1323:
1318:
1312:
1310:
1306:
1301:
1297:
1292:
1287:
1283:
1279:
1276:(5): 517–22.
1275:
1271:
1267:
1260:
1257:
1252:
1248:
1242:
1239:
1234:
1230:
1224:
1221:
1217:
1213:
1208:
1206:
1204:
1200:
1196:
1192:
1187:
1185:
1183:
1179:
1172:
1170:
1168:
1164:
1160:
1152:
1150:
1148:
1144:
1140:
1136:
1132:
1124:
1122:
1120:
1117:
1113:
1109:
1105:
1093:
1088:
1084:
1080:
1077:
1073:
1066:
1064:
1061:
1057:
1053:
1049:
1046:
1042:
1038:
1031:
1029:
1023:
1019:
1016:
1010:
1008:
1002:
998:
995:
991:
984:
982:
976:
972:
969:
963:
961:
955:
951:
948:
946:RefSeq (mRNA)
944:
937:
936:
931:
927:
924:
918:
917:
912:
908:
905:
903:
899:
892:
891:
886:
882:
879:
873:
872:
867:
863:
860:
858:
854:
847:
846:
841:
837:
834:
828:
827:
822:
818:
815:
813:
809:
806:
803:
801:
798:
794:
791:
787:
783:
776:
772:
767:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
712:
710:
707:
706:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
616:
615:Gene ontology
612:
608:
596:
591:
587:
580:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
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1910:expanding it
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1797:
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1758:
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1711:
1680:
1676:
1642:(1): 45–54.
1639:
1636:Nat. Immunol
1635:
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1586:
1555:
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1512:
1508:
1479:
1475:
1450:
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1421:
1417:
1376:(1): 45–54.
1373:
1370:Nat. Immunol
1369:
1363:
1338:
1334:
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1269:
1259:
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1241:
1232:
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1156:
1153:Interactions
1128:
1115:
1107:
1103:
1102:
1025:
1004:
978:
957:
933:
914:
888:
869:
843:
824:
804:
799:
536:spermatocyte
412:
405:
350:19|19 A
132:External IDs
67:
1683:(1): 40–5.
1482:(2): 50–2.
730:proteolysis
694:nucleoplasm
462:granulocyte
270:64,001,811
257:63,985,853
110:Identifiers
1949:Categories
1755:Genome Res
1712:Genome Res
1677:Nat. Genet
1552:Chem. Biol
1509:Genome Res
1335:Biochem. J
1218:, May 2017
1197:, May 2017
1173:References
1141:and an E3
755:DNA repair
416:(ortholog)
371:7,183,681
358:7,175,567
153:HomoloGene
1900:on human
1843:FEBS Lett
1135:ubiquitin
1108:otubain-1
1028:NP_598911
1007:NP_060140
981:NM_134150
960:NM_017670
790:Orthologs
679:cytoplasm
161:GeneCards
1873:24766989
1865:16364312
1822:16189514
1785:15489334
1742:15231748
1699:14702039
1664:27005972
1656:14661020
1627:12477932
1574:12401499
1539:11042152
1496:10664582
1398:27005972
1390:14661020
1355:18954305
1300:12704427
1270:EMBO Rep
1214:–
1193:–
1159:interact
1147:cytokine
1131:cysteine
1125:Function
1076:Wikidata
769:Sources:
508:yolk sac
1830:4427026
1802:Bibcode
1595:Bibcode
1467:9373149
1438:8125298
1291:1319179
1216:Ensembl
1195:Ensembl
902:UniProt
857:Ensembl
796:Species
775:QuickGO
699:cytosol
689:nucleus
391:pattern
249:11q13.1
149:2147616
117:Aliases
1871:
1863:
1828:
1820:
1794:Nature
1783:
1776:528928
1773:
1740:
1733:442148
1730:
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1618:139241
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1530:310934
1527:
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1167:GNB2L1
1163:RNF128
1112:enzyme
1110:is an
1062:search
1060:PubMed
935:Q7TQI3
916:Q96FW1
845:107260
812:Entrez
562:BioGPS
520:morula
157:134542
141:608337
1904:is a
1869:S2CID
1826:S2CID
1660:S2CID
1394:S2CID
1161:with
1116:OTUB1
826:55611
805:Mouse
800:Human
771:Amigo
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
165:OTUB1
124:OTUB1
22:OTUB1
1906:stub
1898:gene
1861:PMID
1818:PMID
1781:PMID
1738:PMID
1695:PMID
1652:PMID
1623:PMID
1570:PMID
1535:PMID
1492:PMID
1463:PMID
1447:Gene
1434:PMID
1418:Gene
1386:PMID
1351:PMID
1296:PMID
1165:and
1119:gene
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
137:OMIM
94:4LDT
90:4I6L
86:4DHZ
82:4DDI
78:4DDG
74:3VON
70:2ZFY
51:RCSB
48:PDBe
1851:doi
1847:580
1810:doi
1798:437
1771:PMC
1763:doi
1728:PMC
1720:doi
1685:doi
1644:doi
1613:PMC
1603:doi
1560:doi
1525:PMC
1517:doi
1484:doi
1455:doi
1451:200
1426:doi
1422:138
1378:doi
1343:doi
1339:418
1286:PMC
1278:doi
528:lip
367:End
266:End
169:OMA
145:MGI
41:PDB
1951::
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