1321:. OCT-4 consists of an octamer motif, a particular DNA sequence of AGTCAAAT that binds to their target genes and activates or deactivates certain expressions. These gene expressions then lead to phenotypic changes in stem cell differentiation during the development of a mammalian embryo. It plays a vital role in determining the fates of both inner mass cells and embryonic stem cells and has the ability to maintain pluripotency throughout embryonic development. Recently, it has been noted that OCT-4 not only maintains pluripotency in embryonic cells but also has the ability to regulate cancer cell proliferation and can be found in various cancers such as pancreatic, lung, liver and testicular germ cell tumors in adult germ cells. Another defect this gene can have is dysplastic growth in epithelial tissues which are caused by a lack of OCT-4 within the epithelial cells.
333:
310:
207:
232:
598:
591:
584:
1682:, fail to induce pluripotency, thus demonstrating the exclusiveness of Oct4 among POU transcription factors. However, later it was shown that Oct4 could be completely omitted from the Yamanaka cocktail, and the remaining three factors, Sox2, Klf4, and cMyc (SKM) could generate mouse iPSCs with dramatically enhanced developmental potential. This suggests that Oct4 increases the efficiency of reprogramming, but decreases the quality of resulting iPSCs.
1708:. In cells that already express high level of Oct3/4, exogenously transfected Oct3/4 will lead to the repression of Rex1. However, in cells that are not actively expressing Oct3/4, exogenous transfection of Oct3/4 will lead to the activation of Rex1. This implies a dual regulatory ability of Oct3/4 on Rex1. At low levels of the Oct3/4 protein, the Rex1 promoter is activated, while at high levels of the Oct3/4 protein, the Rex1 promoter is repressed.
1674:. The use of Thomson reprogramming factors avoids the need to overexpress c-Myc, an oncogene. It was later determined that only two of these four factors, namely Oct4 and Klf4, are sufficient to reprogram mouse adult neural stem cells. Finally it was shown that a single factor, Oct-4 was sufficient for this transformation. Moreover, while Sox2, Klf4, and cMyc could be replaced by their respective family members, Oct4's closer relatives,
339:
238:
1621:. A decrease in Sox2 accompanies increased levels of Oct-4 to promote a mesendodermal fate, with Oct-4 actively inhibiting ectodermal differentiation. Repressed Oct-4 levels that lead to ectodermal differentiation are accompanied by an increase in Sox2, which effectively inhibits mesendodermal differentiation. Niwa et al. suggested that their findings established a role for Oct-4 as a
56:
1628:
The transcription factors Oct-4, Sox2, and Nanog are part of a complex regulatory network, with Oct-4 and Sox2 being capable of directly regulating Nanog by binding to its promoter, and are essential for maintaining the self-renewing undifferentiated state of the inner cell mass of the blastocyst,
1616:
and mesoderm. In contrast, repression of Oct-4 induces loss of pluripotency and dedifferentiation to trophectoderm. Thus, a critical amount of Oct-4 is required to sustain stem cell self-renewal, and up- or down-regulation induces divergent developmental programs. Changes to Oct-4 levels do not
1611:
In 2000, Niwa et al. used conditional expression and repression in murine embryonic stem cells to determine requirements for Oct-4 in the maintenance of developmental potency. Although transcriptional determination has often been considered as a binary on-off control system, they found that the
82:
1633:
lines (which are cell lines derived from the inner cell mass), and induced pluripotent stem cells. While differential up- and down-regulation of Oct-4 and Sox2 has been shown to promote differentiation, down-regulation of Nanog must occur for differentiation to proceed.
1816:
ENSG00000206454, ENSG00000204531, ENSG00000237582, ENSG00000229094, ENSG00000233911, ENSG00000235068 GRCh38: Ensembl release 89: ENSG00000230336, ENSG00000206454, ENSG00000204531, ENSG00000237582, ENSG00000229094, ENSG00000233911,
4326:
4229:
Baal N, Reisinger K, Jahr H, Bohle RM, Liang O, Münstedt K, et al. (October 2004). "Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood".
1735:
Oct3/4 represses Suv39h1 expression through the activation of an antisense long non-coding RNA. Suv39h1 inhibition maintains low level of H3K9me3 in pluripotent cells limiting the formation of heterochromatin.
4319:
4044:
Looijenga LH, Stoop H, de Leeuw HP, de
Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, et al. (May 2003). "POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors".
2249:
Looijenga LH, Stoop H, de Leeuw HP, de
Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, et al. (May 2003). "POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors".
1572:
DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homodimers and/or heterodimers in a sequence-specific manner.
3919:
Butteroni C, De Felici M, Schöler HR, Pesce M (December 2000). "Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins".
3684:
Crouau-Roy B, Amadou C, Bouissou C, Clayton J, Vernet C, Ribouchon MT, et al. (May 1994). "Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping".
2875:"Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site"
1360:. Therefore, the level of Oct-4 expression in mice is vital for regulating pluripotency and early cell differentiation since one of its main functions is to keep the embryo from differentiating.
5248:
9738:
4312:
2776:
Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, et al. (January 2008). "Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts".
5747:
1337:
and remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. Gene knockdown of Oct-4 promotes
1625:
of pluripotency that controls lineage commitment and illustrated the sophistication of critical transcriptional regulators and the consequent importance of quantitative analyzes.
2676:
Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, et al. (July 2008). "Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors".
3489:
Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, et al. (February 2006). "G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis".
2625:
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. (December 2007). "Induced pluripotent stem cell lines derived from human somatic cells".
2533:
Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, et al. (July 2007). "In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state".
7954:
3713:
Guillaudeux T, Mattei MG, Depetris D, Le
Bouteiller P, Pontarotti P (1993). "In situ hybridization localizes the human OTF3 to chromosome 6p21.3→p22 and OTF3L to 12p13".
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5654:
5649:
5644:
5293:
3417:
Lamoury FM, Croitoru-Lamoury J, Brew BJ (2006). "Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1".
5278:
4964:
3808:"The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors"
1749:(i.e. stem cells from epithelium, bone marrow, liver, etc.). Other scientists have produced evidence to the contrary, and dismiss those studies as artifacts of
5787:
1695:
experiments of mouse embryonic stem cells, Oct-4 has often been used as a marker of stemness, as differentiated cells show reduced expression of this marker.
9582:
9566:
4385:
2469:
Heurtier, V., Owens, N., Gonzalez, I. et al. The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nat Commun 10, 1109 (2019).
5639:
1991:
Niwa H, Miyazaki J, Smith AG (April 2000). "Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells".
931:
2145:"Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes"
912:
168:
5424:
5417:
5412:
5400:
5395:
5390:
5385:
5380:
5308:
1892:"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues"
9304:
3742:
Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (October 1995). "Expression of transcription regulating genes in human preimplantation embryos".
1473:
1504:
1405:
6103:
1436:
1612:
precise level of Oct-4 governs 3 distinct fates of ES cells. An increase in expression of less than 2-fold causes differentiation into primitive
3528:"Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency"
5162:
4188:"Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells"
4067:"The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells"
1872:
3612:
Schoorlemmer J, Kruijer W (December 1991). "Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells".
1854:
9758:
2033:
Zeineddine, Dana et al. “The Oct4 protein: more than a magic stemness marker.” American journal of stem cells vol. 3,2 74-82. 5 Sep. 2014
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79:
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4531:
1310:
for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.
9336:
8235:
6322:
1594:
of the skin and intestine. The intestinal dysplasia resulted from an increase in progenitor cell population and the upregulation of
1208:
1201:
309:
5780:
5775:
5703:
5693:
4570:
4560:
4395:
1719:
5698:
5612:
1732:
knockout of the gene in human embryonic stem cells demonstrated that Oct-4 is essential for the development after fertilisation.
1658:(OSKM) in mice, demonstrating its capacity to induce an embryonic stem-cell-like state. These factors are often referred to as "
8634:
5910:
5900:
4501:
4380:
1841:
1820:
6265:
5905:
5600:
3993:"The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression"
1837:
231:
206:
9547:
9542:
8693:
5605:
4295:
1815:
1643:
9763:
9642:
7978:
6128:
5681:
5671:
148:
3886:"Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1"
8147:
8142:
7693:
5770:
5688:
5676:
4752:
1341:, demonstrating a role for these factors in human embryonic stem cell self-renewal. Oct-4 can form a heterodimer with
345:
244:
4110:"Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers"
3571:"Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers"
5883:
4881:
1663:
338:
237:
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6180:
6165:
6148:
6143:
6138:
6133:
6044:
6019:
5895:
5807:
5797:
4954:
4427:
3030:"OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency"
2482:
Okita K, Ichisaka T, Yamanaka S (July 2007). "Generation of germline-competent induced pluripotent stem cells".
9041:
8676:
8192:
7765:
7604:
6539:
6534:
6519:
5994:
5969:
5851:
5802:
5595:
4986:
4452:
4278:
2371:"Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues"
2202:"Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues"
1338:
1002:
156:
9406:
7447:
6764:
5878:
5866:
1791:
1716:
983:
979:
969:
965:
961:
957:
953:
3448:"Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of OCT4 and Nanog"
9537:
7584:
7579:
5974:
5871:
5666:
5627:
4690:
4339:
3843:"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4"
3082:"Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis"
1667:
1299:
9529:
9089:
5888:
5824:
5819:
5632:
4708:
3841:
Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, et al. (October 1998).
2586:"Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution"
1313:
Octamer-binding transcription factor 4, OCT-4, is a transcription factor protein that is encoded by the
4274:
9110:
9102:
6940:
6422:
5947:
5942:
5937:
5617:
5500:
4335:
4004:
3268:"Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker"
3266:
Zangrossi S, Marabese M, Broggini M, Giordano R, D'Erasmo M, Montelatici E, et al. (July 2007).
3176:
Lengner CJ, Camargo FD, Hochedlinger K, Welstead GG, Zaidi S, Gokhale S, et al. (October 2007).
3128:
2984:
2685:
2634:
2542:
2491:
2156:
1651:
1489:
1484:
1268:
1159:
220:
4304:
2971:
Fogarty NM, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, et al. (October 2017).
135:
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9128:
8824:
7027:
6232:
5814:
5792:
5765:
5727:
5661:
1771:
1630:
1303:
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1141:
1137:
1133:
1109:
1084:
1080:
1076:
3771:
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996).
1520:
1515:
1457:
1452:
1447:
1421:
1416:
8962:
4255:
4217:
3872:
3637:
3557:
3514:
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3395:
3297:
2801:
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2709:
2658:
2566:
2515:
2400:
2307:
2231:
2074:
2016:
1699:
1591:
1587:
1368:
180:
1184:
1149:
1145:
1113:
1088:
1072:
1348:
Mouse embryos that are Oct-4 deficient or have low expression levels of Oct-4 fail to form the
597:
590:
583:
8544:
8535:
8172:
7120:
5861:
5856:
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4174:
4139:
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4032:
3979:
3936:
3907:
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3759:
3730:
3701:
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3629:
3600:
3549:
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3469:
3434:
3387:
3346:
3289:
3248:
3207:
3156:
3103:
3059:
3028:
Bernard LD, Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, et al. (July 2022).
3010:
2953:
2904:
2852:
2793:
2750:
2727:
Kim JB, Sebastiano V, Wu G, Araúzo-Bravo MJ, Sasse P, Gentile L, et al. (February 2009).
2701:
2650:
2607:
2558:
2507:
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2351:
2299:
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2223:
2182:
2125:
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2008:
1970:
1921:
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128:
72:
8355:
8350:
8345:
8340:
8335:
1939:
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. (September 2005).
7427:
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7053:
5622:
5569:
5343:
4239:
4199:
4164:
4129:
4121:
4086:
4078:
4022:
4012:
3969:
3961:
3928:
3897:
3854:
3819:
3784:
3751:
3722:
3693:
3662:
3651:"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues"
3621:
3590:
3582:
3539:
3498:
3459:
3426:
3377:
3336:
3328:
3279:
3238:
3226:
3197:
3189:
3146:
3136:
3115:
Kim JH, Jee MK, Lee SY, Han TH, Kim BS, Kang KS, et al. (September 2009). Mei L (ed.).
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1307:
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176:
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8510:
8460:
8450:
8430:
8415:
8395:
8320:
8300:
7442:
7437:
3117:"Regulation of adipose tissue stromal cells behaviors by endogenic Oct4 expression control"
9212:
8435:
8305:
7671:
7629:
7624:
7619:
7557:
7469:
7391:
7179:
7130:
7125:
5172:
4299:
4151:
Rajpert-De Meyts E, Hanstein R, Jørgensen N, Graem N, Vogt PH, Skakkebaek NE (June 2004).
3755:
3317:"OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer"
1757:
giving false detection of Oct-4 expression. Oct-4 has also been implicated as a marker of
1746:
1349:
1330:
400:
4293:
Generating iPS Cells from MEFS through Forced
Expression of Sox-2, Oct-4, c-Myc, and Klf4
4008:
3132:
2988:
2689:
2638:
2546:
2495:
2423:"Pluripotency factors in embryonic stem cells regulate differentiation into germ layers"
2160:
9309:
7589:
7572:
5715:
5370:
4367:
4287:
4091:
4066:
3667:
3650:
3341:
3316:
3202:
3177:
3151:
3116:
3054:
3029:
3005:
2972:
2948:
2923:
2847:
2820:
2584:
Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, et al. (June 2007).
2447:
2422:
2276:
Zaehres H, Lensch MW, Daheron L, Stewart SA, Itskovitz-Eldor J, Daley GQ (March 2005).
2177:
2144:
2120:
2093:
1965:
1940:
1786:
1534:
4134:
4109:
4027:
3992:
3859:
3842:
3595:
3570:
2899:
2874:
2821:"Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs"
2819:
Velychko S, Adachi K, Kim KP, Hou Y, MacCarthy CM, Wu G, et al. (December 2019).
1916:
1891:
1711:
Oct4 contributes to the rapid cell cycle of ESCs by promoting progression through the
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
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771:
766:
761:
756:
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746:
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689:
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669:
664:
659:
654:
649:
644:
639:
9752:
8167:
7507:
5932:
5720:
5048:
4186:
Matin MM, Walsh JR, Gokhale PJ, Draper JS, Bahrami AR, Morton I, et al. (2005).
3991:
Guo Y, Costa R, Ramsey H, Starnes T, Vance G, Robertson K, et al. (March 2002).
3974:
3965:
3950:"Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4"
3949:
3625:
1357:
626:
4221:
4153:"Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads"
3876:
3561:
3518:
3481:
3399:
3301:
2662:
2020:
9717:
9029:
8912:
8904:
8275:
8231:
7234:
7082:
4259:
3641:
2805:
2762:
2713:
2570:
2404:
2311:
2235:
2078:
1595:
1429:
1398:
1353:
418:
197:
160:
2519:
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184:
9401:
9004:
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7199:
7164:
5553:
5358:
5353:
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4600:
4595:
4491:
4371:
4108:
Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M (August 2003).
3569:
Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M (August 2003).
3544:
3527:
3464:
3447:
3284:
3267:
2294:
2277:
1877:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1859:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1781:
1745:
Several studies suggest a role for Oct-4 in sustaining self-renewal capacity of
1729:
1497:
4292:
4204:
4187:
3997:
Proceedings of the
National Academy of Sciences of the United States of America
3193:
2837:
2745:
2728:
2602:
2585:
2438:
2387:
2370:
2218:
2201:
2168:
1956:
501:
9713:
9664:
9136:
8740:
8649:
8629:
8602:
7949:
7698:
7547:
7535:
7530:
6529:
6524:
5288:
5283:
5261:
5127:
4945:
4649:
4590:
4585:
4565:
3430:
3332:
1754:
1554:
1318:
1295:
1276:
832:
regulation of heart induction by regulation of canonical Wnt signaling pathway
317:
214:
164:
3824:
3807:
3366:"OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer"
3080:
Tai MH, Chang CC, Kiupel M, Webster JD, Olson LK, Trosko JE (February 2005).
2470:
1907:
139:, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4, POU class 5 homeobox 1, Oct3/4
9587:
9577:
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9034:
8053:
5758:
5187:
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4152:
3098:
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1617:
independently promote differentiation, but are also controlled by levels of
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561:
439:
384:
371:
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270:
172:
40:
33:
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4017:
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2705:
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2511:
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2355:
2346:
2329:
2328:
Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, et al. (July 2005).
2303:
2262:
2227:
2186:
2129:
2070:
2012:
1974:
3868:
3833:
3798:
3763:
3734:
3705:
3676:
3633:
3178:"Oct4 expression is not required for mouse somatic stem cell self-renewal"
3045:
2908:
2890:
2421:
Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S (June 2011).
2110:
2061:
2044:
1925:
1753:
culture, or interpreting background noise as signal, and warn about Oct-4
1248:
1243:
9054:
8832:
7194:
5753:
5710:
4762:
4243:
1941:"Core transcriptional regulatory circuitry in human embryonic stem cells"
1712:
1613:
1291:
1264:
1232:
1047:
1028:
3243:
2996:
2697:
2554:
2503:
1666:, reverting human fibroblast cells to iPSCs via Oct-4, along with Sox2,
675:
DNA-binding transcription repressor activity, RNA polymerase II-specific
9454:
9434:
9429:
9141:
7115:
6899:
4811:
4806:
4801:
4789:
4784:
4125:
4082:
3789:
3772:
3586:
2939:
1776:
1280:
1014:
943:
4065:
Wang P, Branch DR, Bali M, Schultz GA, Goss PE, Jin T (October 2003).
3726:
3382:
3365:
105:
101:
55:
9635:
9630:
9625:
9615:
9610:
9329:
8884:
8879:
8874:
8869:
8135:
8130:
8007:
8002:
7997:
7982:
7973:
7968:
7963:
7942:
7856:
7851:
7639:
7634:
7614:
7609:
7599:
7594:
7432:
7384:
7379:
7374:
7369:
7339:
7334:
7329:
7324:
7294:
7244:
7239:
7002:
6922:
6894:
6889:
6884:
6879:
6874:
6869:
6864:
6859:
6854:
6849:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6759:
6754:
6749:
6709:
6662:
6657:
6652:
6647:
6642:
6637:
6627:
6615:
6610:
6376:
6371:
6366:
6248:
6243:
6215:
6210:
6195:
6190:
6185:
6175:
6170:
6158:
6153:
5525:
5520:
5515:
5510:
5505:
5480:
5407:
5375:
5318:
5313:
5100:
5095:
5090:
4974:
4779:
4669:
4664:
4637:
4632:
4627:
4553:
4284:
1675:
1590:
of the factor in adult mice has been found to cause the formation of
1334:
1216:
898:
680:
DNA-binding transcription factor activity, RNA polymerase II-specific
3502:
2789:
17:
9679:
9657:
9652:
9620:
9509:
9504:
9449:
9444:
9439:
9383:
9292:
9287:
9282:
9277:
9272:
9267:
9262:
9257:
9205:
9200:
9188:
9183:
9178:
9173:
9161:
9156:
9151:
9146:
9115:
9082:
9077:
9072:
9019:
9014:
9009:
8984:
8942:
8937:
8932:
8927:
8922:
8917:
8889:
8842:
8837:
8783:
8778:
8773:
8768:
8745:
8520:
8505:
8500:
8495:
8490:
8485:
8480:
8475:
8470:
8465:
8455:
8445:
8440:
8425:
8420:
8410:
8405:
8400:
8390:
8385:
8380:
8375:
8370:
8365:
8360:
8330:
8325:
8315:
8310:
8295:
8290:
8285:
8280:
8214:
8209:
8204:
8177:
8152:
8120:
8113:
8108:
8014:
7987:
7959:
7937:
7932:
7927:
7922:
7817:
7812:
7757:
7750:
7745:
7730:
7703:
7364:
7359:
7354:
7349:
7344:
7319:
7314:
7309:
7304:
7299:
7289:
7284:
7279:
7274:
7269:
7264:
7259:
7254:
7249:
7229:
7224:
7219:
7214:
7209:
7204:
7189:
7184:
7009:
6997:
6992:
6987:
6982:
6950:
6945:
6744:
6734:
6729:
6724:
6719:
6714:
6704:
6699:
6694:
6689:
6605:
6595:
6588:
6583:
6578:
6573:
6563:
6507:
6502:
6497:
6492:
6487:
6482:
6477:
6398:
6393:
6388:
6332:
6327:
6226:
6205:
6200:
6074:
6069:
6064:
6059:
6054:
6049:
5256:
5021:
5016:
5011:
5001:
4996:
4991:
4981:
4969:
4919:
4899:
4840:
4828:
4823:
4747:
4740:
4735:
4725:
4718:
4713:
4644:
4575:
4548:
4543:
4526:
4521:
4516:
4511:
4506:
4496:
4484:
4479:
4457:
4447:
4442:
4432:
3773:"Generation and analysis of 280,000 human expressed sequence tags"
2004:
1671:
1598:
transcription through the inhibition of cellular differentiation.
3806:
Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997).
1642:
Oct-4 is one of the transcription factors that is used to create
1586:
Oct-4 has been implicated in tumorigenesis of adult germ cells.
861:
857:
9706:
9701:
9696:
9686:
9674:
9669:
9516:
9499:
9363:
9358:
9353:
9324:
9319:
9252:
9247:
9242:
9237:
9232:
9227:
9222:
9217:
9168:
9062:
9024:
8999:
8994:
8989:
8972:
8864:
8857:
8852:
8733:
8728:
8723:
8718:
8713:
8708:
8703:
8698:
8688:
8681:
8671:
8666:
8654:
8644:
8639:
8622:
8617:
8612:
8595:
8590:
8585:
8560:
8555:
8550:
8268:
8263:
8258:
8253:
8248:
8187:
8162:
8157:
8098:
8093:
8088:
8083:
8078:
8073:
8068:
8063:
8058:
8029:
8024:
7917:
7912:
7907:
7902:
7888:
7883:
7878:
7873:
7868:
7839:
7834:
7829:
7795:
7790:
7785:
7780:
7775:
7770:
7735:
7723:
7718:
7713:
7666:
7661:
7656:
7651:
7646:
7567:
7552:
7542:
7518:
7513:
7499:
7494:
7489:
7479:
7474:
7462:
7457:
7401:
7396:
7174:
7159:
7154:
7142:
7137:
6970:
6965:
6960:
6804:
6739:
6684:
6679:
6674:
6558:
6553:
6548:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6415:
6410:
6354:
6349:
6317:
6312:
6307:
6297:
6292:
6285:
6280:
6275:
6270:
6260:
6255:
6238:
6096:
6091:
6086:
6014:
5475:
5470:
5465:
5460:
5455:
5450:
5363:
5348:
5325:
5298:
5271:
5266:
5231:
5209:
5204:
5199:
5182:
5177:
5167:
5157:
5107:
5065:
5060:
5043:
5038:
5033:
4931:
4926:
4914:
4872:
4867:
4857:
4772:
4767:
4757:
4676:
4659:
4622:
4610:
4605:
4580:
4538:
4467:
4462:
4437:
4420:
4415:
4410:
4405:
4400:
4390:
3227:"The pluripotency regulator Oct4: a role in somatic stem cells?"
2278:"High-efficiency RNA interference in human embryonic stem cells"
1704:
1679:
1647:
1618:
1342:
1287:
802:
regulation of DNA methylation-dependent heterochromatin assembly
762:
cell fate commitment involved in formation of primary germ layer
152:
9477:
8806:
7048:
5548:
4350:
4308:
2973:"Genome editing reveals a role for OCT4 in human embryogenesis"
2924:"Oct-4 controls cell-cycle progression of embryonic stem cells"
606:
9348:
8977:
8967:
8847:
8243:
7800:
7149:
6600:
6337:
5831:
5303:
5132:
5122:
5117:
4909:
4904:
2873:
Ben-Shushan E, Thompson JR, Gudas LJ, Bergman Y (April 1998).
1723:
1655:
3446:
Hough SR, Clements I, Welch PJ, Wiederholt KA (June 2006).
2369:
Hochedlinger K, Yamada Y, Beard C, Jaenisch R (May 2005).
2200:
Hochedlinger K, Yamada Y, Beard C, Jaenisch R (May 2005).
2055:(5–6). Springer Science and Business Media LLC: 321–329.
1662:". This reprogramming effect has also been seen with the
842:
positive regulation of transcription by RNA polymerase II
787:
negative regulation of transcription by RNA polymerase II
408:
3364:
Atlasi Y, Mowla SJ, Ziaee SA, Bahrami AR (April 2007).
847:
positive regulation of SMAD protein signal transduction
2729:"Oct4-induced pluripotency in adult neural stem cells"
2330:"Transcriptional regulation of nanog by OCT4 and SOX2"
2045:"Stem cell pluripotency and transcription factor Oct4"
2155:(1). Springer Science and Business Media LLC: 14806.
2043:
Pan GJ, Chang ZY, Schöler HR, Pei D (December 2002).
1715:, specifically through transcriptional inhibition of
573:
2922:
Lee J, Go Y, Kang I, Han YM, Kim J (February 2010).
1329:
Oct-4 transcription factor is initially active as a
9596:
9556:
9525:
9490:
9415:
9392:
9374:
9124:
9098:
9050:
8953:
8900:
8820:
8754:
8571:
8531:
8227:
8044:
7684:
7410:
7098:
7079:
7067:
7018:
6931:
6910:
6112:
6032:
6003:
5983:
5958:
5921:
5840:
5736:
5584:
5565:
5491:
5436:
5334:
5244:
5220:
5143:
5076:
4940:
4890:
4699:
4685:
4363:
1173:
1132:
1102:
1065:
3225:Lengner CJ, Welstead GG, Jaenisch R (March 2008).
1833:
1831:
1829:
1811:
1809:
1807:
2104:(1). Springer Science and Business Media LLC: 7.
822:BMP signaling pathway involved in heart induction
355:
254:
2143:Saha SK, Jeong Y, Cho S, Cho SG (October 2018).
1345:, so that these two proteins bind DNA together.
3948:Ezashi T, Ghosh D, Roberts RM (December 2001).
2416:
2414:
2094:"Role of Oct4 in the early embryo development"
1986:
1984:
1838:GRCm38: Ensembl release 89: ENSMUSG00000024406
1444:NC_000006.10, 31246432-31240107 (Minus Strand)
1371:of Oct-4 in humans and other species include:
757:negative regulation of gene silencing by miRNA
9739:transcription factor/coregulator deficiencies
8810:β-Scaffold factors with minor groove contacts
4320:
1890:Takeda J, Seino S, Bell GI (September 1992).
1512:NC_007127.1, 27995548-28000317 (Minus strand)
1413:NC_000083.4, 35114104..35118822 (Plus Strand)
8:
2323:
2321:
3526:Gerrard L, Zhao D, Clark AJ, Cui W (2005).
665:transcription cis-regulatory region binding
9487:
9474:
8817:
8803:
7095:
7076:
7064:
7045:
5581:
5562:
5545:
4696:
4360:
4347:
4327:
4313:
4305:
3649:Wey E, Lyons GE, Schäfer BW (March 1994).
2471:https://doi.org/10.1038/s41467-019-09041-z
1559:Found in Pit-Oct-Unc transcription factors
1481:NW_001084776, 650467-655015 (Minus strand)
1129:
948:
872:
747:regulation of transcription, DNA-templated
622:
396:
295:
192:
90:
4277:at the U.S. National Library of Medicine
4203:
4168:
4133:
4090:
4026:
4016:
3973:
3901:
3858:
3823:
3788:
3666:
3594:
3543:
3463:
3381:
3340:
3283:
3242:
3201:
3150:
3140:
3097:
3053:
3004:
2947:
2898:
2846:
2836:
2744:
2601:
2446:
2386:
2345:
2293:
2217:
2176:
2119:
2109:
2060:
1964:
1915:
1698:Oct3/4 can both repress and activate the
1279:, class 5, transcription factor 1), is a
655:DNA-binding transcription factor activity
39:"Oct-3" redirects here. For the day, see
1539:
1373:
752:somatic stem cell population maintenance
2868:
2866:
1803:
777:mRNA transcription by RNA polymerase II
27:Mammalian protein found in Homo sapiens
1306:. As such, it is frequently used as a
782:regulation of asymmetric cell division
45:
3884:Gonzalez MI, Robins DM (March 2001).
3756:10.1093/oxfordjournals.humrep.a135792
360:
321:
316:
259:
218:
213:
7:
5493:(1.6) Basic helix-span-helix (bHSH)
3890:The Journal of Biological Chemistry
3812:The Journal of Biological Chemistry
2334:The Journal of Biological Chemistry
1298:. It is critically involved in the
3668:10.1111/j.1432-1033.1994.tb18676.x
1602:Pluripotency in embryo development
1170:
1099:
1062:
1038:
1019:
993:
922:
903:
807:multicellular organism development
792:transcription by RNA polymerase II
772:anatomical structure morphogenesis
767:endodermal cell fate specification
578:
496:
434:
413:
25:
1283:that in humans is encoded by the
3966:10.1128/MCB.21.23.7883-7891.2001
3655:European Journal of Biochemistry
1292:homeodomain transcription factor
685:ubiquitin protein ligase binding
596:
589:
582:
344:
337:
331:
308:
243:
236:
230:
205:
54:
9480:(0) Other transcription factors
8764:transcriptional enhancer factor
4381:Activating transcription factor
3370:International Journal of Cancer
1460:(N-terminal truncated isoform)
812:cardiac cell fate determination
716:transcription regulator complex
3954:Molecular and Cellular Biology
3715:Cytogenetics and Cell Genetics
2879:Molecular and Cellular Biology
1660:Yamanaka reprogramming factors
1644:induced pluripotent stem cells
607:More reference expression data
562:More reference expression data
1:
8694:Interferon regulatory factors
6933:(2.5) Alternating composition
6129:General transcription factors
3860:10.1016/S0092-8674(00)81769-9
1664:Thomson reprogramming factors
1533:Oct-4 contains the following
827:regulation of gene expression
645:sequence-specific DNA binding
329:
228:
7979:Octamer transcription factor
4687:(1.2) Basic helix-loop-helix
3921:Journal of Molecular Biology
3626:10.1016/0925-4773(91)90074-G
3315:Kim RJ, Nam JS (June 2011).
3142:10.1371/journal.pone.0007166
797:transcription, DNA-templated
660:transcription factor binding
9759:Genes on human chromosome 6
4753:Myogenic regulatory factors
3545:10.1634/stemcells.2004-0102
3465:10.1634/stemcells.2005-0475
3285:10.1634/stemcells.2006-0611
2295:10.1634/stemcells.2004-0252
2212:(3). Elsevier BV: 465–477.
1951:(6). Elsevier BV: 947–956.
9780:
4275:Oct-4+Transcription+Factor
4232:Thrombosis and Haemostasis
4205:10.1634/stemcells.22-5-659
3321:Laboratory Animal Research
3194:10.1016/j.stem.2007.07.020
2838:10.1016/j.stem.2019.10.002
2746:10.1016/j.cell.2009.01.023
2603:10.1016/j.stem.2007.05.014
2439:10.1016/j.cell.2011.05.017
2388:10.1016/j.cell.2005.02.018
2219:10.1016/j.cell.2005.02.018
2169:10.1038/s41598-018-33094-7
1957:10.1016/j.cell.2005.08.020
474:mucosa of transverse colon
38:
31:
9734:
9486:
9473:
8816:
8802:
8573:(3.5) Tryptophan clusters
7063:
7044:
5561:
5544:
4359:
4346:
3614:Mechanisms of Development
3431:10.1080/14653240600735875
3333:10.5625/lar.2011.27.2.147
2092:Wu G, Schöler HR (2014).
1873:"Mouse PubMed Reference:"
1855:"Human PubMed Reference:"
1356:, and differentiate into
1247:
1242:
1238:
1231:
1215:
1196:
1177:
1156:
1125:
1106:
1069:
1058:
1045:
1041:
1026:
1022:
1013:
1000:
996:
977:
951:
942:
929:
925:
910:
906:
897:
882:
875:
871:
855:
625:
621:
604:
581:
572:
559:
508:
499:
446:
437:
407:
399:
395:
378:
365:
328:
307:
298:
294:
277:
264:
227:
204:
195:
191:
146:
143:
133:
126:
121:
98:
93:
76:
71:
66:
62:
53:
48:
9394:(4.10) Cold-shock domain
4279:Medical Subject Headings
3825:10.1074/jbc.272.47.29852
1747:adult somatic stem cells
1319:POU (Pit-Oct-Unc) family
1317:gene and is part of the
1209:Chr 17: 35.82 – 35.82 Mb
4340:intracellular receptors
4114:Genes & Development
4071:The Biochemical Journal
3575:Genes & Development
2928:The Biochemical Journal
2647:10.1126/science.1151526
1792:Gene regulatory network
1717:cyclin-dependent kinase
1686:In embryonic stem cells
1646:(iPSCs), together with
1582:Implications in disease
1325:Expression and function
1202:Chr 6: 31.16 – 31.18 Mb
4018:10.1073/pnas.062041099
3933:10.1006/jmbi.2000.4238
3903:10.1074/jbc.M008689200
3698:10.1006/geno.1994.1249
3034:Nucleic Acids Research
2347:10.1074/jbc.M502573200
1908:10.1093/nar/20.17.4613
1896:Nucleic Acids Research
1455:(full length isoform)
837:blastocyst development
362:17 B1|17 18.69 cM
9103:TATA-binding proteins
4336:Transcription factors
4170:10.1093/humrep/deh265
3099:10.1093/carcin/bgh321
2891:10.1128/mcb.18.4.1866
2111:10.1186/2045-9769-3-7
2062:10.1038/sj.cr.7290134
1638:Role in reprogramming
1410:17,17 B1; 17 19.23 cM
323:Chromosome 17 (mouse)
4244:10.1160/TH04-02-0079
2778:Nature Biotechnology
1304:embryonic stem cells
1302:of undifferentiated
1269:transcription factor
817:response to wounding
532:primordial germ cell
221:Chromosome 6 (human)
94:List of PDB id codes
67:Available structures
9764:POU-domain proteins
9598:(0.6) Miscellaneous
9129:High-mobility group
8825:Rel homology region
5815:Testicular receptor
5556:DNA-binding domains
4009:2002PNAS...99.3663G
3491:Nature Cell Biology
3244:10.4161/cc.7.6.5573
3133:2009PLoSO...4.7166K
3046:10.1093/nar/gkac550
2997:10.1038/nature24033
2989:2017Natur.550...67F
2698:10.1038/nature07061
2690:2008Natur.454..646K
2639:2007Sci...318.1917Y
2555:10.1038/nature05944
2547:2007Natur.448..318W
2504:10.1038/nature05934
2496:2007Natur.448..313O
2161:2018NatSR...814806S
1741:In adult stem cells
1631:embryonic stem cell
8963:p53 p63 p73 family
8536:Heat shock factors
4298:2008-04-09 at the
4157:Human Reproduction
4126:10.1101/gad.269303
4083:10.1042/BJ20030579
3790:10.1101/gr.6.9.807
3744:Human Reproduction
3587:10.1101/gad.269303
2940:10.1042/BJ20091439
2149:Scientific Reports
1592:dysplastic lesions
1588:Ectopic expression
1271:4), also known as
1003:ENSMUSG00000024406
740:Biological process
699:Cellular component
633:Molecular function
454:right uterine tube
185:POU5F1 - orthologs
9746:
9745:
9730:
9729:
9726:
9725:
9469:
9468:
9465:
9464:
8798:
8797:
8794:
8793:
8040:
8039:
7680:
7679:
7040:
7039:
7036:
7035:
6028:
6027:
5884:Mineralocorticoid
5540:
5539:
5536:
5535:
5240:
5239:
4353:(1) Basic domains
4077:(Pt 1): 199–205.
3727:10.1159/000133537
3383:10.1002/ijc.22508
3040:(13): 7367–7379.
2831:(6): 737–753.e4.
2633:(5858): 1917–20.
2098:Cell Regeneration
1759:cancer stem cells
1579:
1578:
1526:
1525:
1467:Rattus norvegicus
1392:RefSeq (protein)
1258:
1257:
1254:
1253:
1227:
1226:
1192:
1191:
1167:
1166:
1121:
1120:
1096:
1095:
1054:
1053:
1035:
1034:
1009:
1008:
990:
989:
938:
937:
919:
918:
867:
866:
617:
616:
613:
612:
568:
567:
555:
554:
493:
492:
482:left uterine tube
391:
390:
290:
289:
117:
116:
113:
112:
77:Ortholog search:
32:For the day, see
16:(Redirected from
9771:
9570:-related factors
9488:
9475:
9376:(4.9) Grainyhead
8818:
8804:
8756:(3.6) TEA domain
8046:(3.2) Paired box
7687:
7421:
7415:
7109:
7103:
7096:
7092:
7086:
7077:
7065:
7054:Helix-turn-helix
7046:
6008:
5988:
5963:
5926:
5896:Estrogen related
5845:
5741:
5589:
5582:
5570:Nuclear receptor
5563:
5546:
5225:
5146:
5079:
4948:
4893:
4702:
4697:
4361:
4348:
4329:
4322:
4315:
4306:
4263:
4225:
4207:
4182:
4172:
4147:
4137:
4104:
4094:
4061:
4040:
4030:
4020:
3987:
3977:
3944:
3915:
3905:
3880:
3862:
3837:
3827:
3802:
3792:
3767:
3738:
3709:
3680:
3670:
3645:
3608:
3598:
3565:
3547:
3522:
3485:
3467:
3442:
3404:
3403:
3385:
3361:
3355:
3354:
3344:
3312:
3306:
3305:
3287:
3263:
3257:
3256:
3246:
3222:
3216:
3215:
3205:
3173:
3167:
3164:
3154:
3144:
3111:
3101:
3074:
3068:
3067:
3057:
3025:
3019:
3018:
3008:
2968:
2962:
2961:
2951:
2919:
2913:
2912:
2902:
2870:
2861:
2860:
2850:
2840:
2816:
2810:
2809:
2773:
2767:
2766:
2748:
2724:
2718:
2717:
2684:(7204): 646–50.
2673:
2667:
2666:
2622:
2616:
2615:
2605:
2581:
2575:
2574:
2541:(7151): 318–24.
2530:
2524:
2523:
2479:
2473:
2467:
2461:
2460:
2450:
2418:
2409:
2408:
2390:
2366:
2360:
2359:
2349:
2325:
2316:
2315:
2297:
2273:
2267:
2266:
2246:
2240:
2239:
2221:
2197:
2191:
2190:
2180:
2140:
2134:
2133:
2123:
2113:
2089:
2083:
2082:
2064:
2040:
2034:
2031:
2025:
2024:
1988:
1979:
1978:
1968:
1936:
1930:
1929:
1919:
1887:
1881:
1880:
1869:
1863:
1862:
1851:
1845:
1835:
1824:
1813:
1623:master regulator
1540:
1374:
1240:
1239:
1211:
1204:
1187:
1171:
1162:
1130:
1126:RefSeq (protein)
1116:
1100:
1091:
1063:
1039:
1020:
994:
973:
949:
923:
904:
873:
623:
609:
600:
593:
586:
579:
564:
544:primitive streak
504:
502:Top expressed in
497:
466:body of pancreas
442:
440:Top expressed in
435:
414:
397:
387:
374:
363:
348:
341:
335:
324:
312:
296:
286:
273:
262:
247:
240:
234:
223:
209:
193:
187:
138:
131:
108:
91:
85:
64:
63:
58:
46:
21:
9779:
9778:
9774:
9773:
9772:
9770:
9769:
9768:
9749:
9748:
9747:
9742:
9722:
9592:
9552:
9521:
9482:
9461:
9411:
9388:
9370:
9120:
9094:
9046:
8949:
8896:
8812:
8790:
8750:
8567:
8527:
8223:
8036:
7685:
7676:
7417:
7416:
7411:
7406:
7105:
7104:
7099:
7088:
7087:
7080:
7059:
7032:
7014:
6927:
6915:
6906:
6121:
6117:
6108:
6037:
6034:(2.2) Other Cys
6024:
6004:
5999:
5984:
5979:
5959:
5954:
5922:
5917:
5852:Steroid hormone
5841:
5836:
5737:
5732:
5596:Thyroid hormone
5585:
5576:
5557:
5532:
5487:
5432:
5330:
5236:
5223:
5221:
5216:
5144:
5139:
5077:
5072:
4943:
4941:
4936:
4891:
4886:
4700:
4681:
4355:
4342:
4333:
4300:Wayback Machine
4271:
4266:
4228:
4185:
4150:
4120:(16): 2048–59.
4107:
4064:
4046:Cancer Research
4043:
3990:
3960:(23): 7883–91.
3947:
3918:
3883:
3840:
3818:(47): 29852–8.
3805:
3777:Genome Research
3770:
3750:(10): 2787–92.
3741:
3712:
3683:
3648:
3611:
3581:(16): 2048–59.
3568:
3525:
3503:10.1038/ncb1353
3488:
3445:
3416:
3412:
3410:Further reading
3407:
3376:(7): 1598–602.
3363:
3362:
3358:
3314:
3313:
3309:
3265:
3264:
3260:
3224:
3223:
3219:
3175:
3174:
3170:
3114:
3079:
3075:
3071:
3027:
3026:
3022:
2983:(7674): 67–73.
2970:
2969:
2965:
2921:
2920:
2916:
2872:
2871:
2864:
2818:
2817:
2813:
2790:10.1038/nbt1374
2775:
2774:
2770:
2726:
2725:
2721:
2675:
2674:
2670:
2624:
2623:
2619:
2583:
2582:
2578:
2532:
2531:
2527:
2490:(7151): 313–7.
2481:
2480:
2476:
2468:
2464:
2420:
2419:
2412:
2368:
2367:
2363:
2340:(26): 24731–7.
2327:
2326:
2319:
2275:
2274:
2270:
2251:Cancer Research
2248:
2247:
2243:
2199:
2198:
2194:
2142:
2141:
2137:
2091:
2090:
2086:
2042:
2041:
2037:
2032:
2028:
1993:Nature Genetics
1990:
1989:
1982:
1938:
1937:
1933:
1902:(17): 4613–20.
1889:
1888:
1884:
1871:
1870:
1866:
1853:
1852:
1848:
1836:
1827:
1817:ENSG00000235068
1814:
1805:
1801:
1796:
1767:
1743:
1688:
1640:
1609:
1604:
1584:
1535:protein domains
1531:
1456:
1366:
1350:inner cell mass
1339:differentiation
1331:maternal factor
1327:
1249:View/Edit Mouse
1244:View/Edit Human
1207:
1200:
1197:Location (UCSC)
1183:
1179:
1158:
1152:
1148:
1144:
1140:
1136:
1112:
1108:
1087:
1083:
1079:
1075:
1071:
984:ENSG00000235068
982:
980:ENSG00000233911
972:
970:ENSG00000229094
968:
966:ENSG00000237582
964:
962:ENSG00000204531
960:
958:ENSG00000206454
956:
954:ENSG00000230336
952:
851:
735:
694:
670:protein binding
605:
595:
594:
588:
587:
560:
551:
546:
542:
540:inner cell mass
538:
534:
530:
526:
522:
518:
514:
500:
489:
484:
480:
476:
472:
470:body of stomach
468:
464:
460:
456:
452:
438:
382:
369:
361:
351:
350:
349:
342:
322:
299:Gene location (
281:
268:
260:
250:
249:
248:
241:
219:
196:Gene location (
147:
134:
127:
100:
78:
44:
37:
28:
23:
22:
15:
12:
11:
5:
9777:
9775:
9767:
9766:
9761:
9751:
9750:
9744:
9743:
9735:
9732:
9731:
9728:
9727:
9724:
9723:
9721:
9720:
9711:
9710:
9709:
9704:
9699:
9689:
9684:
9683:
9682:
9677:
9672:
9662:
9661:
9660:
9655:
9645:
9640:
9639:
9638:
9633:
9628:
9623:
9618:
9613:
9602:
9600:
9594:
9593:
9591:
9590:
9585:
9580:
9574:
9572:
9554:
9553:
9551:
9550:
9545:
9540:
9534:
9532:
9523:
9522:
9520:
9519:
9514:
9513:
9512:
9507:
9496:
9494:
9484:
9483:
9478:
9471:
9470:
9467:
9466:
9463:
9462:
9460:
9459:
9458:
9457:
9452:
9447:
9442:
9437:
9432:
9421:
9419:
9413:
9412:
9410:
9409:
9404:
9398:
9396:
9390:
9389:
9387:
9386:
9380:
9378:
9372:
9371:
9369:
9368:
9367:
9366:
9361:
9356:
9351:
9341:
9340:
9339:
9334:
9333:
9332:
9327:
9322:
9307:
9302:
9297:
9296:
9295:
9290:
9285:
9280:
9275:
9270:
9265:
9260:
9255:
9250:
9245:
9240:
9235:
9230:
9225:
9220:
9210:
9209:
9208:
9203:
9193:
9192:
9191:
9186:
9181:
9176:
9166:
9165:
9164:
9159:
9154:
9149:
9139:
9133:
9131:
9122:
9121:
9119:
9118:
9113:
9107:
9105:
9096:
9095:
9093:
9092:
9087:
9086:
9085:
9080:
9075:
9070:
9059:
9057:
9048:
9047:
9045:
9044:
9039:
9038:
9037:
9032:
9027:
9022:
9017:
9012:
9007:
9002:
8997:
8992:
8982:
8981:
8980:
8975:
8970:
8959:
8957:
8955:(4.3) p53-like
8951:
8950:
8948:
8947:
8946:
8945:
8940:
8935:
8930:
8925:
8920:
8909:
8907:
8898:
8897:
8895:
8894:
8893:
8892:
8887:
8882:
8877:
8872:
8862:
8861:
8860:
8855:
8850:
8845:
8840:
8829:
8827:
8814:
8813:
8807:
8800:
8799:
8796:
8795:
8792:
8791:
8789:
8788:
8787:
8786:
8781:
8776:
8771:
8760:
8758:
8752:
8751:
8749:
8748:
8743:
8738:
8737:
8736:
8731:
8726:
8721:
8716:
8711:
8706:
8701:
8691:
8686:
8685:
8684:
8679:
8674:
8669:
8659:
8658:
8657:
8652:
8647:
8642:
8632:
8627:
8626:
8625:
8620:
8615:
8605:
8600:
8599:
8598:
8593:
8588:
8577:
8575:
8569:
8568:
8566:
8565:
8564:
8563:
8558:
8553:
8540:
8538:
8529:
8528:
8526:
8525:
8524:
8523:
8518:
8513:
8508:
8503:
8498:
8493:
8488:
8483:
8478:
8473:
8468:
8463:
8458:
8453:
8448:
8443:
8438:
8433:
8428:
8423:
8418:
8413:
8408:
8403:
8398:
8393:
8388:
8383:
8378:
8373:
8368:
8363:
8358:
8353:
8348:
8343:
8338:
8333:
8328:
8323:
8318:
8313:
8308:
8303:
8298:
8293:
8288:
8283:
8273:
8272:
8271:
8266:
8261:
8256:
8251:
8240:
8238:
8225:
8224:
8222:
8221:
8220:
8219:
8218:
8217:
8212:
8207:
8197:
8196:
8195:
8190:
8180:
8175:
8165:
8160:
8155:
8150:
8145:
8140:
8139:
8138:
8133:
8123:
8118:
8117:
8116:
8111:
8103:
8102:
8101:
8096:
8091:
8086:
8081:
8076:
8071:
8066:
8061:
8050:
8048:
8042:
8041:
8038:
8037:
8035:
8034:
8033:
8032:
8027:
8017:
8012:
8011:
8010:
8005:
8000:
7995:
7990:
7985:
7976:
7971:
7966:
7957:
7947:
7946:
7945:
7940:
7935:
7930:
7925:
7920:
7915:
7910:
7905:
7895:
7894:
7893:
7892:
7891:
7886:
7881:
7876:
7871:
7861:
7860:
7859:
7854:
7844:
7843:
7842:
7837:
7832:
7822:
7821:
7820:
7815:
7805:
7804:
7803:
7798:
7793:
7788:
7783:
7778:
7773:
7760:
7755:
7754:
7753:
7748:
7738:
7733:
7728:
7727:
7726:
7721:
7716:
7706:
7701:
7696:
7690:
7688:
7682:
7681:
7678:
7677:
7675:
7674:
7669:
7664:
7659:
7654:
7649:
7644:
7643:
7642:
7637:
7632:
7627:
7622:
7617:
7612:
7607:
7602:
7597:
7592:
7582:
7577:
7576:
7575:
7570:
7560:
7555:
7550:
7545:
7540:
7539:
7538:
7533:
7523:
7522:
7521:
7516:
7504:
7503:
7502:
7497:
7492:
7487:
7482:
7477:
7467:
7466:
7465:
7460:
7450:
7445:
7440:
7435:
7430:
7424:
7422:
7408:
7407:
7405:
7404:
7399:
7394:
7389:
7388:
7387:
7382:
7377:
7372:
7367:
7362:
7357:
7352:
7347:
7342:
7337:
7332:
7327:
7322:
7317:
7312:
7307:
7302:
7297:
7292:
7287:
7282:
7277:
7272:
7267:
7262:
7257:
7252:
7247:
7242:
7237:
7232:
7227:
7222:
7217:
7212:
7207:
7202:
7192:
7187:
7182:
7177:
7173:extended Hox:
7171:
7170:
7169:
7168:
7167:
7162:
7157:
7147:
7146:
7145:
7135:
7134:
7133:
7128:
7112:
7110:
7093:
7074:
7061:
7060:
7049:
7042:
7041:
7038:
7037:
7034:
7033:
7031:
7030:
7024:
7022:
7016:
7015:
7013:
7012:
7007:
7006:
7005:
7000:
6995:
6990:
6985:
6975:
6974:
6973:
6968:
6963:
6953:
6948:
6943:
6937:
6935:
6929:
6928:
6926:
6925:
6919:
6917:
6913:
6908:
6907:
6905:
6904:
6903:
6902:
6897:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6667:
6666:
6665:
6660:
6655:
6650:
6645:
6640:
6635:
6630:
6620:
6619:
6618:
6613:
6603:
6598:
6593:
6592:
6591:
6586:
6581:
6576:
6566:
6561:
6556:
6551:
6546:
6545:
6544:
6543:
6542:
6537:
6532:
6527:
6522:
6512:
6511:
6510:
6505:
6500:
6495:
6490:
6485:
6480:
6475:
6470:
6465:
6460:
6455:
6450:
6445:
6440:
6435:
6420:
6419:
6418:
6413:
6403:
6402:
6401:
6396:
6391:
6381:
6380:
6379:
6374:
6369:
6359:
6358:
6357:
6352:
6342:
6341:
6340:
6335:
6330:
6325:
6320:
6315:
6310:
6300:
6295:
6290:
6289:
6288:
6283:
6278:
6273:
6263:
6258:
6253:
6252:
6251:
6246:
6241:
6229:
6223:
6222:
6221:
6220:
6219:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6173:
6168:
6163:
6162:
6161:
6156:
6146:
6141:
6136:
6125:
6123:
6119:
6115:
6110:
6109:
6107:
6106:
6101:
6100:
6099:
6094:
6089:
6079:
6078:
6077:
6072:
6067:
6062:
6057:
6052:
6041:
6039:
6035:
6030:
6029:
6026:
6025:
6023:
6022:
6017:
6011:
6009:
6001:
6000:
5998:
5997:
5991:
5989:
5981:
5980:
5978:
5977:
5972:
5966:
5964:
5956:
5955:
5953:
5952:
5951:
5950:
5945:
5940:
5929:
5927:
5919:
5918:
5916:
5915:
5914:
5913:
5908:
5903:
5893:
5892:
5891:
5886:
5881:
5879:Glucocorticoid
5876:
5875:
5874:
5869:
5859:
5848:
5846:
5838:
5837:
5835:
5834:
5829:
5828:
5827:
5822:
5812:
5811:
5810:
5805:
5800:
5790:
5785:
5784:
5783:
5778:
5768:
5763:
5762:
5761:
5756:
5744:
5742:
5734:
5733:
5731:
5730:
5725:
5724:
5723:
5718:
5708:
5707:
5706:
5701:
5696:
5686:
5685:
5684:
5679:
5674:
5664:
5659:
5658:
5657:
5652:
5647:
5637:
5636:
5635:
5630:
5620:
5615:
5610:
5609:
5608:
5603:
5592:
5590:
5579:
5574:
5559:
5558:
5549:
5542:
5541:
5538:
5537:
5534:
5533:
5531:
5530:
5529:
5528:
5523:
5518:
5513:
5508:
5497:
5495:
5489:
5488:
5486:
5485:
5484:
5483:
5478:
5473:
5468:
5463:
5458:
5453:
5442:
5440:
5434:
5433:
5431:
5430:
5429:
5428:
5422:
5421:
5420:
5415:
5405:
5404:
5403:
5398:
5393:
5388:
5383:
5368:
5367:
5366:
5361:
5356:
5351:
5340:
5338:
5332:
5331:
5329:
5328:
5323:
5322:
5321:
5316:
5306:
5301:
5296:
5291:
5286:
5281:
5276:
5275:
5274:
5269:
5259:
5253:
5251:
5242:
5241:
5238:
5237:
5235:
5234:
5228:
5226:
5218:
5217:
5215:
5214:
5213:
5212:
5207:
5202:
5192:
5191:
5190:
5185:
5180:
5175:
5170:
5165:
5160:
5149:
5147:
5141:
5140:
5138:
5137:
5136:
5135:
5130:
5125:
5120:
5110:
5105:
5104:
5103:
5098:
5093:
5082:
5080:
5074:
5073:
5071:
5070:
5069:
5068:
5063:
5053:
5052:
5051:
5046:
5041:
5036:
5026:
5025:
5024:
5019:
5014:
5006:
5005:
5004:
4999:
4994:
4984:
4979:
4978:
4977:
4972:
4962:
4957:
4951:
4949:
4938:
4937:
4935:
4934:
4929:
4924:
4923:
4922:
4917:
4912:
4902:
4896:
4894:
4888:
4887:
4885:
4884:
4879:
4878:
4877:
4876:
4875:
4870:
4860:
4850:
4849:
4848:
4843:
4833:
4832:
4831:
4826:
4816:
4815:
4814:
4809:
4804:
4794:
4793:
4792:
4787:
4777:
4776:
4775:
4770:
4765:
4760:
4750:
4745:
4744:
4743:
4738:
4728:
4723:
4722:
4721:
4716:
4705:
4703:
4694:
4683:
4682:
4680:
4679:
4674:
4673:
4672:
4667:
4662:
4652:
4647:
4642:
4641:
4640:
4635:
4630:
4625:
4615:
4614:
4613:
4608:
4603:
4598:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4557:
4556:
4551:
4546:
4536:
4535:
4534:
4529:
4524:
4519:
4514:
4509:
4499:
4494:
4489:
4488:
4487:
4482:
4472:
4471:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4425:
4424:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4377:
4375:
4368:leucine zipper
4357:
4356:
4351:
4344:
4343:
4334:
4332:
4331:
4324:
4317:
4309:
4303:
4302:
4290:
4282:
4270:
4269:External links
4267:
4265:
4264:
4226:
4183:
4163:(6): 1338–44.
4148:
4105:
4062:
4052:(9): 2244–50.
4041:
3988:
3945:
3916:
3881:
3838:
3803:
3768:
3739:
3710:
3681:
3646:
3620:(1–2): 75–86.
3609:
3566:
3523:
3486:
3458:(6): 1467–75.
3443:
3413:
3411:
3408:
3406:
3405:
3356:
3307:
3278:(7): 1675–80.
3258:
3217:
3182:Cell Stem Cell
3168:
3166:
3165:
3112:
3092:(2): 495–502.
3086:Carcinogenesis
3069:
3020:
2963:
2914:
2885:(4): 1866–78.
2862:
2825:Cell Stem Cell
2811:
2768:
2719:
2668:
2617:
2590:Cell Stem Cell
2576:
2525:
2474:
2462:
2410:
2361:
2317:
2288:(3): 299–305.
2268:
2257:(9): 2244–50.
2241:
2192:
2135:
2084:
2035:
2026:
1980:
1931:
1882:
1864:
1846:
1825:
1802:
1800:
1797:
1795:
1794:
1789:
1787:RNA polymerase
1784:
1779:
1774:
1768:
1766:
1763:
1742:
1739:
1738:
1737:
1733:
1727:
1709:
1696:
1687:
1684:
1654:, and often c-
1639:
1636:
1608:
1605:
1603:
1600:
1583:
1580:
1577:
1576:
1573:
1570:
1564:
1563:
1560:
1557:
1551:
1550:
1547:
1544:
1530:
1527:
1524:
1523:
1518:
1513:
1510:
1507:
1502:
1493:
1492:
1487:
1482:
1479:
1476:
1471:
1462:
1461:
1450:
1445:
1442:
1439:
1434:
1425:
1424:
1419:
1414:
1411:
1408:
1403:
1394:
1393:
1390:
1387:
1384:
1381:
1378:
1365:
1362:
1326:
1323:
1256:
1255:
1252:
1251:
1246:
1236:
1235:
1229:
1228:
1225:
1224:
1222:
1220:
1213:
1212:
1205:
1198:
1194:
1193:
1190:
1189:
1175:
1174:
1168:
1165:
1164:
1160:NP_001272915.1
1154:
1153:
1127:
1123:
1122:
1119:
1118:
1104:
1103:
1097:
1094:
1093:
1067:
1066:
1060:
1056:
1055:
1052:
1051:
1043:
1042:
1036:
1033:
1032:
1024:
1023:
1017:
1011:
1010:
1007:
1006:
998:
997:
991:
988:
987:
975:
974:
946:
940:
939:
936:
935:
927:
926:
920:
917:
916:
908:
907:
901:
895:
894:
889:
884:
880:
879:
869:
868:
865:
864:
853:
852:
850:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
743:
741:
737:
736:
734:
733:
728:
723:
718:
713:
708:
702:
700:
696:
695:
693:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
636:
634:
630:
629:
619:
618:
615:
614:
611:
610:
602:
601:
576:
570:
569:
566:
565:
557:
556:
553:
552:
550:
549:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
506:
505:
494:
491:
490:
488:
487:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
444:
443:
431:
430:
422:
411:
405:
404:
401:RNA expression
393:
392:
389:
388:
380:
376:
375:
367:
364:
359:
353:
352:
343:
336:
330:
326:
325:
320:
314:
313:
305:
304:
292:
291:
288:
287:
279:
275:
274:
266:
263:
258:
252:
251:
242:
235:
229:
225:
224:
217:
211:
210:
202:
201:
189:
188:
145:
141:
140:
132:
124:
123:
119:
118:
115:
114:
111:
110:
96:
95:
87:
86:
75:
69:
68:
60:
59:
51:
50:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9776:
9765:
9762:
9760:
9757:
9756:
9754:
9741:
9740:
9733:
9719:
9715:
9712:
9708:
9705:
9703:
9700:
9698:
9695:
9694:
9693:
9690:
9688:
9685:
9681:
9678:
9676:
9673:
9671:
9668:
9667:
9666:
9663:
9659:
9656:
9654:
9651:
9650:
9649:
9646:
9644:
9641:
9637:
9634:
9632:
9629:
9627:
9624:
9622:
9619:
9617:
9614:
9612:
9609:
9608:
9607:
9604:
9603:
9601:
9599:
9595:
9589:
9586:
9584:
9581:
9579:
9576:
9575:
9573:
9571:
9568:
9565:
9562:
9559:
9555:
9549:
9546:
9544:
9541:
9539:
9536:
9535:
9533:
9531:
9530:Pocket domain
9528:
9524:
9518:
9515:
9511:
9508:
9506:
9503:
9502:
9501:
9498:
9497:
9495:
9493:
9492:(0.2) HMGI(Y)
9489:
9485:
9481:
9476:
9472:
9456:
9453:
9451:
9448:
9446:
9443:
9441:
9438:
9436:
9433:
9431:
9428:
9427:
9426:
9423:
9422:
9420:
9418:
9414:
9408:
9405:
9403:
9400:
9399:
9397:
9395:
9391:
9385:
9382:
9381:
9379:
9377:
9373:
9365:
9362:
9360:
9357:
9355:
9352:
9350:
9347:
9346:
9345:
9342:
9338:
9335:
9331:
9328:
9326:
9323:
9321:
9318:
9317:
9316:
9313:
9312:
9311:
9308:
9306:
9303:
9301:
9298:
9294:
9291:
9289:
9286:
9284:
9281:
9279:
9276:
9274:
9271:
9269:
9266:
9264:
9261:
9259:
9256:
9254:
9251:
9249:
9246:
9244:
9241:
9239:
9236:
9234:
9231:
9229:
9226:
9224:
9221:
9219:
9216:
9215:
9214:
9211:
9207:
9204:
9202:
9199:
9198:
9197:
9194:
9190:
9187:
9185:
9182:
9180:
9177:
9175:
9172:
9171:
9170:
9167:
9163:
9160:
9158:
9155:
9153:
9150:
9148:
9145:
9144:
9143:
9140:
9138:
9135:
9134:
9132:
9130:
9127:
9123:
9117:
9114:
9112:
9109:
9108:
9106:
9104:
9101:
9097:
9091:
9088:
9084:
9081:
9079:
9076:
9074:
9071:
9069:
9066:
9065:
9064:
9061:
9060:
9058:
9056:
9053:
9049:
9043:
9040:
9036:
9033:
9031:
9028:
9026:
9023:
9021:
9018:
9016:
9013:
9011:
9008:
9006:
9003:
9001:
8998:
8996:
8993:
8991:
8988:
8987:
8986:
8983:
8979:
8976:
8974:
8971:
8969:
8966:
8965:
8964:
8961:
8960:
8958:
8956:
8952:
8944:
8941:
8939:
8936:
8934:
8931:
8929:
8926:
8924:
8921:
8919:
8916:
8915:
8914:
8911:
8910:
8908:
8906:
8903:
8899:
8891:
8888:
8886:
8883:
8881:
8878:
8876:
8873:
8871:
8868:
8867:
8866:
8863:
8859:
8856:
8854:
8851:
8849:
8846:
8844:
8841:
8839:
8836:
8835:
8834:
8831:
8830:
8828:
8826:
8823:
8819:
8815:
8811:
8805:
8801:
8785:
8782:
8780:
8777:
8775:
8772:
8770:
8767:
8766:
8765:
8762:
8761:
8759:
8757:
8753:
8747:
8744:
8742:
8739:
8735:
8732:
8730:
8727:
8725:
8722:
8720:
8717:
8715:
8712:
8710:
8707:
8705:
8702:
8700:
8697:
8696:
8695:
8692:
8690:
8687:
8683:
8680:
8678:
8675:
8673:
8670:
8668:
8665:
8664:
8663:
8660:
8656:
8653:
8651:
8648:
8646:
8643:
8641:
8638:
8637:
8636:
8633:
8631:
8628:
8624:
8621:
8619:
8616:
8614:
8611:
8610:
8609:
8606:
8604:
8601:
8597:
8594:
8592:
8589:
8587:
8584:
8583:
8582:
8579:
8578:
8576:
8574:
8570:
8562:
8559:
8557:
8554:
8552:
8549:
8548:
8547:
8546:
8542:
8541:
8539:
8537:
8534:
8530:
8522:
8519:
8517:
8514:
8512:
8509:
8507:
8504:
8502:
8499:
8497:
8494:
8492:
8489:
8487:
8484:
8482:
8479:
8477:
8474:
8472:
8469:
8467:
8464:
8462:
8459:
8457:
8454:
8452:
8449:
8447:
8444:
8442:
8439:
8437:
8434:
8432:
8429:
8427:
8424:
8422:
8419:
8417:
8414:
8412:
8409:
8407:
8404:
8402:
8399:
8397:
8394:
8392:
8389:
8387:
8384:
8382:
8379:
8377:
8374:
8372:
8369:
8367:
8364:
8362:
8359:
8357:
8354:
8352:
8349:
8347:
8344:
8342:
8339:
8337:
8334:
8332:
8329:
8327:
8324:
8322:
8319:
8317:
8314:
8312:
8309:
8307:
8304:
8302:
8299:
8297:
8294:
8292:
8289:
8287:
8284:
8282:
8279:
8278:
8277:
8274:
8270:
8267:
8265:
8262:
8260:
8257:
8255:
8252:
8250:
8247:
8246:
8245:
8242:
8241:
8239:
8237:
8233:
8230:
8226:
8216:
8213:
8211:
8208:
8206:
8203:
8202:
8201:
8198:
8194:
8191:
8189:
8186:
8185:
8184:
8181:
8179:
8176:
8174:
8171:
8170:
8169:
8166:
8164:
8161:
8159:
8156:
8154:
8151:
8149:
8146:
8144:
8141:
8137:
8134:
8132:
8129:
8128:
8127:
8124:
8122:
8119:
8115:
8112:
8110:
8107:
8106:
8104:
8100:
8097:
8095:
8092:
8090:
8087:
8085:
8082:
8080:
8077:
8075:
8072:
8070:
8067:
8065:
8062:
8060:
8057:
8056:
8055:
8052:
8051:
8049:
8047:
8043:
8031:
8028:
8026:
8023:
8022:
8021:
8018:
8016:
8013:
8009:
8006:
8004:
8001:
7999:
7996:
7994:
7991:
7989:
7986:
7984:
7980:
7977:
7975:
7972:
7970:
7967:
7965:
7961:
7958:
7956:
7953:
7952:
7951:
7948:
7944:
7941:
7939:
7936:
7934:
7931:
7929:
7926:
7924:
7921:
7919:
7916:
7914:
7911:
7909:
7906:
7904:
7901:
7900:
7899:
7896:
7890:
7887:
7885:
7882:
7880:
7877:
7875:
7872:
7870:
7867:
7866:
7865:
7862:
7858:
7855:
7853:
7850:
7849:
7848:
7845:
7841:
7838:
7836:
7833:
7831:
7828:
7827:
7826:
7823:
7819:
7816:
7814:
7811:
7810:
7809:
7806:
7802:
7799:
7797:
7794:
7792:
7789:
7787:
7784:
7782:
7779:
7777:
7774:
7772:
7769:
7768:
7767:
7764:
7763:
7761:
7759:
7756:
7752:
7749:
7747:
7744:
7743:
7742:
7739:
7737:
7734:
7732:
7729:
7725:
7722:
7720:
7717:
7715:
7712:
7711:
7710:
7707:
7705:
7702:
7700:
7697:
7695:
7692:
7691:
7689:
7683:
7673:
7670:
7668:
7665:
7663:
7660:
7658:
7655:
7653:
7650:
7648:
7645:
7641:
7638:
7636:
7633:
7631:
7628:
7626:
7623:
7621:
7618:
7616:
7613:
7611:
7608:
7606:
7603:
7601:
7598:
7596:
7593:
7591:
7588:
7587:
7586:
7583:
7581:
7578:
7574:
7571:
7569:
7566:
7565:
7564:
7561:
7559:
7556:
7554:
7551:
7549:
7546:
7544:
7541:
7537:
7534:
7532:
7529:
7528:
7527:
7524:
7520:
7517:
7515:
7512:
7511:
7510:
7509:
7505:
7501:
7498:
7496:
7493:
7491:
7488:
7486:
7483:
7481:
7478:
7476:
7473:
7472:
7471:
7468:
7464:
7461:
7459:
7456:
7455:
7454:
7451:
7449:
7446:
7444:
7441:
7439:
7436:
7434:
7431:
7429:
7426:
7425:
7423:
7420:
7414:
7409:
7403:
7400:
7398:
7395:
7393:
7390:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7366:
7363:
7361:
7358:
7356:
7353:
7351:
7348:
7346:
7343:
7341:
7338:
7336:
7333:
7331:
7328:
7326:
7323:
7321:
7318:
7316:
7313:
7311:
7308:
7306:
7303:
7301:
7298:
7296:
7293:
7291:
7288:
7286:
7283:
7281:
7278:
7276:
7273:
7271:
7268:
7266:
7263:
7261:
7258:
7256:
7253:
7251:
7248:
7246:
7243:
7241:
7238:
7236:
7233:
7231:
7228:
7226:
7223:
7221:
7218:
7216:
7213:
7211:
7208:
7206:
7203:
7201:
7198:
7197:
7196:
7193:
7191:
7188:
7186:
7183:
7181:
7178:
7176:
7172:
7166:
7163:
7161:
7158:
7156:
7153:
7152:
7151:
7148:
7144:
7141:
7140:
7139:
7136:
7132:
7129:
7127:
7124:
7123:
7122:
7119:
7118:
7117:
7114:
7113:
7111:
7108:
7102:
7097:
7094:
7091:
7085:
7084:
7078:
7075:
7073:
7070:
7066:
7062:
7058:
7055:
7052:
7047:
7043:
7029:
7026:
7025:
7023:
7021:
7017:
7011:
7008:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6980:
6979:
6976:
6972:
6969:
6967:
6964:
6962:
6959:
6958:
6957:
6954:
6952:
6949:
6947:
6944:
6942:
6939:
6938:
6936:
6934:
6930:
6924:
6921:
6920:
6918:
6916:
6909:
6901:
6898:
6896:
6893:
6891:
6888:
6886:
6883:
6881:
6878:
6876:
6873:
6871:
6868:
6866:
6863:
6861:
6858:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6826:
6823:
6821:
6818:
6816:
6813:
6811:
6808:
6806:
6803:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6678:
6676:
6673:
6672:
6671:
6668:
6664:
6661:
6659:
6656:
6654:
6651:
6649:
6646:
6644:
6641:
6639:
6636:
6634:
6631:
6629:
6626:
6625:
6624:
6621:
6617:
6614:
6612:
6609:
6608:
6607:
6604:
6602:
6599:
6597:
6594:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6571:
6570:
6567:
6565:
6562:
6560:
6557:
6555:
6552:
6550:
6547:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6517:
6516:
6513:
6509:
6506:
6504:
6501:
6499:
6496:
6494:
6491:
6489:
6486:
6484:
6481:
6479:
6476:
6474:
6471:
6469:
6466:
6464:
6461:
6459:
6456:
6454:
6451:
6449:
6446:
6444:
6441:
6439:
6436:
6434:
6431:
6430:
6429:
6426:
6425:
6424:
6423:Sp/KLF family
6421:
6417:
6414:
6412:
6409:
6408:
6407:
6404:
6400:
6397:
6395:
6392:
6390:
6387:
6386:
6385:
6382:
6378:
6375:
6373:
6370:
6368:
6365:
6364:
6363:
6360:
6356:
6353:
6351:
6348:
6347:
6346:
6343:
6339:
6336:
6334:
6331:
6329:
6326:
6324:
6321:
6319:
6316:
6314:
6311:
6309:
6306:
6305:
6304:
6301:
6299:
6296:
6294:
6291:
6287:
6284:
6282:
6279:
6277:
6274:
6272:
6269:
6268:
6267:
6264:
6262:
6259:
6257:
6254:
6250:
6247:
6245:
6242:
6240:
6237:
6236:
6235:
6234:
6230:
6228:
6225:
6224:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6178:
6177:
6174:
6172:
6169:
6167:
6164:
6160:
6157:
6155:
6152:
6151:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6131:
6130:
6127:
6126:
6124:
6122:
6111:
6105:
6102:
6098:
6095:
6093:
6090:
6088:
6085:
6084:
6083:
6080:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6047:
6046:
6043:
6042:
6040:
6038:
6031:
6021:
6018:
6016:
6013:
6012:
6010:
6007:
6002:
5996:
5993:
5992:
5990:
5987:
5982:
5976:
5973:
5971:
5968:
5967:
5965:
5962:
5957:
5949:
5946:
5944:
5941:
5939:
5936:
5935:
5934:
5931:
5930:
5928:
5925:
5920:
5912:
5909:
5907:
5904:
5902:
5899:
5898:
5897:
5894:
5890:
5887:
5885:
5882:
5880:
5877:
5873:
5870:
5868:
5865:
5864:
5863:
5860:
5858:
5855:
5854:
5853:
5850:
5849:
5847:
5844:
5839:
5833:
5830:
5826:
5823:
5821:
5818:
5817:
5816:
5813:
5809:
5806:
5804:
5801:
5799:
5796:
5795:
5794:
5791:
5789:
5786:
5782:
5779:
5777:
5774:
5773:
5772:
5769:
5767:
5764:
5760:
5757:
5755:
5751:
5750:
5749:
5746:
5745:
5743:
5740:
5735:
5729:
5726:
5722:
5719:
5717:
5714:
5713:
5712:
5709:
5705:
5702:
5700:
5697:
5695:
5692:
5691:
5690:
5687:
5683:
5680:
5678:
5675:
5673:
5670:
5669:
5668:
5665:
5663:
5660:
5656:
5653:
5651:
5648:
5646:
5643:
5642:
5641:
5638:
5634:
5631:
5629:
5626:
5625:
5624:
5621:
5619:
5616:
5614:
5611:
5607:
5604:
5602:
5599:
5598:
5597:
5594:
5593:
5591:
5588:
5583:
5580:
5578:
5571:
5568:
5564:
5560:
5555:
5552:
5547:
5543:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5503:
5502:
5499:
5498:
5496:
5494:
5490:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5448:
5447:
5444:
5443:
5441:
5439:
5435:
5426:
5423:
5419:
5416:
5414:
5411:
5410:
5409:
5406:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5378:
5377:
5374:
5373:
5372:
5369:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5346:
5345:
5342:
5341:
5339:
5337:
5333:
5327:
5324:
5320:
5317:
5315:
5312:
5311:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5273:
5270:
5268:
5265:
5264:
5263:
5260:
5258:
5255:
5254:
5252:
5250:
5247:
5243:
5233:
5230:
5229:
5227:
5219:
5211:
5208:
5206:
5203:
5201:
5198:
5197:
5196:
5193:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5155:
5154:
5151:
5150:
5148:
5142:
5134:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5115:
5114:
5111:
5109:
5106:
5102:
5099:
5097:
5094:
5092:
5089:
5088:
5087:
5084:
5083:
5081:
5075:
5067:
5064:
5062:
5059:
5058:
5057:
5054:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5031:
5030:
5027:
5023:
5020:
5018:
5015:
5013:
5010:
5009:
5007:
5003:
5000:
4998:
4995:
4993:
4990:
4989:
4988:
4985:
4983:
4980:
4976:
4973:
4971:
4968:
4967:
4966:
4963:
4961:
4958:
4956:
4953:
4952:
4950:
4947:
4939:
4933:
4930:
4928:
4925:
4921:
4918:
4916:
4913:
4911:
4908:
4907:
4906:
4903:
4901:
4898:
4897:
4895:
4889:
4883:
4880:
4874:
4871:
4869:
4866:
4865:
4864:
4861:
4859:
4856:
4855:
4854:
4851:
4847:
4844:
4842:
4839:
4838:
4837:
4834:
4830:
4827:
4825:
4822:
4821:
4820:
4817:
4813:
4810:
4808:
4805:
4803:
4800:
4799:
4798:
4795:
4791:
4788:
4786:
4783:
4782:
4781:
4778:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4755:
4754:
4751:
4749:
4746:
4742:
4739:
4737:
4734:
4733:
4732:
4729:
4727:
4724:
4720:
4717:
4715:
4712:
4711:
4710:
4707:
4706:
4704:
4698:
4695:
4692:
4688:
4684:
4678:
4675:
4671:
4668:
4666:
4663:
4661:
4658:
4657:
4656:
4653:
4651:
4648:
4646:
4643:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4620:
4619:
4616:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4593:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4555:
4552:
4550:
4547:
4545:
4542:
4541:
4540:
4537:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4504:
4503:
4500:
4498:
4495:
4493:
4490:
4486:
4483:
4481:
4478:
4477:
4476:
4473:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4430:
4429:
4426:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4383:
4382:
4379:
4378:
4376:
4373:
4369:
4366:
4362:
4358:
4354:
4349:
4345:
4341:
4337:
4330:
4325:
4323:
4318:
4316:
4311:
4310:
4307:
4301:
4297:
4294:
4291:
4289:
4286:
4283:
4280:
4276:
4273:
4272:
4268:
4261:
4257:
4253:
4249:
4245:
4241:
4238:(4): 767–75.
4237:
4233:
4227:
4223:
4219:
4215:
4211:
4206:
4201:
4198:(5): 659–68.
4197:
4193:
4189:
4184:
4180:
4176:
4171:
4166:
4162:
4158:
4154:
4149:
4145:
4141:
4136:
4131:
4127:
4123:
4119:
4115:
4111:
4106:
4102:
4098:
4093:
4088:
4084:
4080:
4076:
4072:
4068:
4063:
4059:
4055:
4051:
4047:
4042:
4038:
4034:
4029:
4024:
4019:
4014:
4010:
4006:
4003:(6): 3663–7.
4002:
3998:
3994:
3989:
3985:
3981:
3976:
3971:
3967:
3963:
3959:
3955:
3951:
3946:
3942:
3938:
3934:
3930:
3927:(4): 529–40.
3926:
3922:
3917:
3913:
3909:
3904:
3899:
3896:(9): 6420–8.
3895:
3891:
3887:
3882:
3878:
3874:
3870:
3866:
3861:
3856:
3853:(3): 379–91.
3852:
3848:
3844:
3839:
3835:
3831:
3826:
3821:
3817:
3813:
3809:
3804:
3800:
3796:
3791:
3786:
3783:(9): 807–28.
3782:
3778:
3774:
3769:
3765:
3761:
3757:
3753:
3749:
3745:
3740:
3736:
3732:
3728:
3724:
3720:
3716:
3711:
3707:
3703:
3699:
3695:
3691:
3687:
3682:
3678:
3674:
3669:
3664:
3661:(3): 753–62.
3660:
3656:
3652:
3647:
3643:
3639:
3635:
3631:
3627:
3623:
3619:
3615:
3610:
3606:
3602:
3597:
3592:
3588:
3584:
3580:
3576:
3572:
3567:
3563:
3559:
3555:
3551:
3546:
3541:
3538:(1): 124–33.
3537:
3533:
3529:
3524:
3520:
3516:
3512:
3508:
3504:
3500:
3497:(2): 188–94.
3496:
3492:
3487:
3483:
3479:
3475:
3471:
3466:
3461:
3457:
3453:
3449:
3444:
3440:
3436:
3432:
3428:
3425:(3): 228–42.
3424:
3420:
3415:
3414:
3409:
3401:
3397:
3393:
3389:
3384:
3379:
3375:
3371:
3367:
3360:
3357:
3352:
3348:
3343:
3338:
3334:
3330:
3327:(2): 147–52.
3326:
3322:
3318:
3311:
3308:
3303:
3299:
3295:
3291:
3286:
3281:
3277:
3273:
3269:
3262:
3259:
3254:
3250:
3245:
3240:
3236:
3232:
3228:
3221:
3218:
3213:
3209:
3204:
3199:
3195:
3191:
3188:(4): 403–15.
3187:
3183:
3179:
3172:
3169:
3162:
3158:
3153:
3148:
3143:
3138:
3134:
3130:
3126:
3122:
3118:
3113:
3109:
3105:
3100:
3095:
3091:
3087:
3083:
3078:
3077:
3076:For example:
3073:
3070:
3065:
3061:
3056:
3051:
3047:
3043:
3039:
3035:
3031:
3024:
3021:
3016:
3012:
3007:
3002:
2998:
2994:
2990:
2986:
2982:
2978:
2974:
2967:
2964:
2959:
2955:
2950:
2945:
2941:
2937:
2934:(2): 171–81.
2933:
2929:
2925:
2918:
2915:
2910:
2906:
2901:
2896:
2892:
2888:
2884:
2880:
2876:
2869:
2867:
2863:
2858:
2854:
2849:
2844:
2839:
2834:
2830:
2826:
2822:
2815:
2812:
2807:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2772:
2769:
2764:
2760:
2756:
2752:
2747:
2742:
2738:
2734:
2730:
2723:
2720:
2715:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2679:
2672:
2669:
2664:
2660:
2656:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2621:
2618:
2613:
2609:
2604:
2599:
2595:
2591:
2587:
2580:
2577:
2572:
2568:
2564:
2560:
2556:
2552:
2548:
2544:
2540:
2536:
2529:
2526:
2521:
2517:
2513:
2509:
2505:
2501:
2497:
2493:
2489:
2485:
2478:
2475:
2472:
2466:
2463:
2458:
2454:
2449:
2444:
2440:
2436:
2433:(6): 875–89.
2432:
2428:
2424:
2417:
2415:
2411:
2406:
2402:
2398:
2394:
2389:
2384:
2381:(3): 465–77.
2380:
2376:
2372:
2365:
2362:
2357:
2353:
2348:
2343:
2339:
2335:
2331:
2324:
2322:
2318:
2313:
2309:
2305:
2301:
2296:
2291:
2287:
2283:
2279:
2272:
2269:
2264:
2260:
2256:
2252:
2245:
2242:
2237:
2233:
2229:
2225:
2220:
2215:
2211:
2207:
2203:
2196:
2193:
2188:
2184:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2139:
2136:
2131:
2127:
2122:
2117:
2112:
2107:
2103:
2099:
2095:
2088:
2085:
2080:
2076:
2072:
2068:
2063:
2058:
2054:
2050:
2049:Cell Research
2046:
2039:
2036:
2030:
2027:
2022:
2018:
2014:
2010:
2006:
2005:10.1038/74199
2002:
1998:
1994:
1987:
1985:
1981:
1976:
1972:
1967:
1962:
1958:
1954:
1950:
1946:
1942:
1935:
1932:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1897:
1893:
1886:
1883:
1878:
1874:
1868:
1865:
1860:
1856:
1850:
1847:
1843:
1839:
1834:
1832:
1830:
1826:
1822:
1818:
1812:
1810:
1808:
1804:
1798:
1793:
1790:
1788:
1785:
1783:
1780:
1778:
1775:
1773:
1770:
1769:
1764:
1762:
1760:
1756:
1752:
1748:
1740:
1734:
1731:
1728:
1725:
1721:
1718:
1714:
1710:
1707:
1706:
1701:
1697:
1694:
1690:
1689:
1685:
1683:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1637:
1635:
1632:
1626:
1624:
1620:
1615:
1606:
1601:
1599:
1597:
1593:
1589:
1581:
1574:
1571:
1569:
1566:
1565:
1561:
1558:
1556:
1553:
1552:
1548:
1545:
1542:
1541:
1538:
1536:
1528:
1522:
1519:
1517:
1514:
1511:
1508:
1506:
1503:
1500:
1499:
1495:
1494:
1491:
1488:
1486:
1483:
1480:
1477:
1475:
1472:
1469:
1468:
1464:
1463:
1459:
1454:
1451:
1449:
1446:
1443:
1440:
1438:
1435:
1432:
1431:
1427:
1426:
1423:
1420:
1418:
1415:
1412:
1409:
1407:
1404:
1401:
1400:
1396:
1395:
1391:
1389:RefSeq (mRNA)
1388:
1385:
1382:
1380:Entrez GeneID
1379:
1376:
1375:
1372:
1370:
1363:
1361:
1359:
1358:trophectoderm
1355:
1351:
1346:
1344:
1340:
1336:
1332:
1324:
1322:
1320:
1316:
1311:
1309:
1305:
1301:
1297:
1293:
1290:. Oct-4 is a
1289:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1250:
1245:
1241:
1237:
1234:
1230:
1223:
1221:
1218:
1214:
1210:
1206:
1203:
1199:
1195:
1188:
1186:
1182:
1176:
1172:
1169:
1163:
1161:
1155:
1151:
1147:
1143:
1139:
1135:
1131:
1128:
1124:
1117:
1115:
1111:
1105:
1101:
1098:
1092:
1090:
1086:
1082:
1078:
1074:
1068:
1064:
1061:
1059:RefSeq (mRNA)
1057:
1050:
1049:
1044:
1040:
1037:
1031:
1030:
1025:
1021:
1018:
1016:
1012:
1005:
1004:
999:
995:
992:
986:
985:
981:
976:
971:
967:
963:
959:
955:
950:
947:
945:
941:
934:
933:
928:
924:
921:
915:
914:
909:
905:
902:
900:
896:
893:
890:
888:
885:
881:
878:
874:
870:
863:
859:
854:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
744:
742:
739:
738:
732:
731:mitochondrion
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
703:
701:
698:
697:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
650:miRNA binding
648:
646:
643:
641:
638:
637:
635:
632:
631:
628:
627:Gene ontology
624:
620:
608:
603:
599:
592:
585:
580:
577:
575:
571:
563:
558:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
510:
507:
503:
498:
495:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
448:
445:
441:
436:
433:
432:
429:
427:
423:
421:
420:
416:
415:
412:
410:
406:
402:
398:
394:
386:
381:
377:
373:
368:
358:
354:
347:
340:
334:
327:
319:
315:
311:
306:
302:
297:
293:
285:
280:
276:
272:
267:
257:
253:
246:
239:
233:
226:
222:
216:
212:
208:
203:
199:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
142:
137:
130:
125:
120:
109:
107:
103:
97:
92:
89:
88:
84:
81:
74:
70:
65:
61:
57:
52:
47:
42:
35:
30:
19:
9736:
9691:
9647:
9605:
9597:
9569:
9563:
9557:
9526:
9491:
9479:
9416:
9393:
9375:
9343:
9314:
9195:
9125:
9099:
9051:
8954:
8901:
8821:
8809:
8763:
8755:
8661:
8607:
8580:
8572:
8543:
8532:
8276:FOX proteins
8236:winged helix
8228:
8199:
8182:
8125:
8045:
8019:
7992:
7897:
7863:
7846:
7824:
7807:
7740:
7708:
7562:
7525:
7506:
7452:
7418:
7412:
7106:
7100:
7089:
7083:Antennapedia
7081:
7068:
7056:
7050:
7019:
6977:
6955:
6932:
6911:
6669:
6622:
6568:
6514:
6427:
6405:
6383:
6361:
6344:
6302:
6231:
6113:
6081:
6033:
6005:
5985:
5960:
5923:
5889:Progesterone
5842:
5738:
5586:
5572:
5566:
5550:
5492:
5445:
5437:
5335:
5245:
5194:
5152:
5112:
5085:
5055:
5028:
4862:
4852:
4835:
4818:
4730:
4686:
4654:
4617:
4474:
4364:
4352:
4235:
4231:
4195:
4191:
4160:
4156:
4117:
4113:
4074:
4070:
4049:
4045:
4000:
3996:
3957:
3953:
3924:
3920:
3893:
3889:
3850:
3846:
3815:
3811:
3780:
3776:
3747:
3743:
3721:(4): 212–4.
3718:
3714:
3692:(1): 241–3.
3689:
3685:
3658:
3654:
3617:
3613:
3578:
3574:
3535:
3531:
3494:
3490:
3455:
3451:
3422:
3418:
3373:
3369:
3359:
3324:
3320:
3310:
3275:
3271:
3261:
3237:(6): 725–8.
3234:
3230:
3220:
3185:
3181:
3171:
3127:(9): e7166.
3124:
3120:
3089:
3085:
3072:
3037:
3033:
3023:
2980:
2976:
2966:
2931:
2927:
2917:
2882:
2878:
2828:
2824:
2814:
2784:(1): 101–6.
2781:
2777:
2771:
2739:(3): 411–9.
2736:
2732:
2722:
2681:
2677:
2671:
2630:
2626:
2620:
2596:(1): 55–70.
2593:
2589:
2579:
2538:
2534:
2528:
2487:
2483:
2477:
2465:
2430:
2426:
2378:
2374:
2364:
2337:
2333:
2285:
2281:
2271:
2254:
2250:
2244:
2209:
2205:
2195:
2152:
2148:
2138:
2101:
2097:
2087:
2052:
2048:
2038:
2029:
1999:(4): 372–6.
1996:
1992:
1948:
1944:
1934:
1899:
1895:
1885:
1876:
1867:
1858:
1849:
1750:
1744:
1703:
1692:
1641:
1627:
1610:
1607:Animal model
1585:
1549:Length (AA)
1532:
1496:
1490:NP_001009178
1485:NM_001009178
1465:
1430:Homo sapiens
1428:
1399:Mus musculus
1397:
1367:
1354:pluripotency
1347:
1328:
1314:
1312:
1300:self-renewal
1284:
1272:
1260:
1259:
1181:NP_001239381
1178:
1157:
1142:NP_001272916
1138:NP_001272915
1134:NP_001167002
1110:NM_001252452
1107:
1085:NM_001285987
1081:NM_001285986
1077:NM_001173531
1070:
1046:
1027:
1001:
978:
930:
911:
891:
886:
462:human kidney
424:
417:
144:External IDs
99:
29:
9417:(4.11) Runt
7072:Homeodomain
6670:zinc finger
6006:subfamily 0
5986:subfamily 6
5961:subfamily 5
5924:subfamily 4
5843:subfamily 3
5739:subfamily 2
5587:subfamily 1
5554:Zinc finger
4797:Neurogenins
4365:(1.1) Basic
3419:Cytotherapy
1782:Pribnow box
1755:pseudogenes
1730:CRISPR-Cas9
1568:Homeodomain
1546:Description
1501:(zebrafish)
1498:Danio rerio
1458:NP_002692.1
1453:NP_002692.2
1448:NM_002701.3
1422:NP_038661.1
1417:NM_013633.1
721:nucleoplasm
690:RNA binding
640:DNA binding
458:endometrium
383:35,821,669
370:35,816,915
282:31,180,731
269:31,164,337
122:Identifiers
9753:Categories
7950:POU domain
7090:ANTP class
7020:(2.6) WRKY
6303:GLI family
5438:(1.5) RF-X
5336:(1.4) NF-1
4285:FactorBook
4192:Stem Cells
3532:Stem Cells
3452:Stem Cells
3272:Stem Cells
3231:Cell Cycle
2282:Stem Cells
1844:, May 2017
1823:, May 2017
1799:References
1720:inhibitors
1555:POU domain
1441:6, 6p21.31
1383:Chromosome
1296:POU family
1277:POU domain
512:blastocyst
428:(ortholog)
165:HomoloGene
9737:see also
9578:Apetala 2
8232:Fork head
6912:(2.4) Cys
6114:(2.3) Cys
4846:Scleraxis
1596:β-catenin
1529:Structure
1521:NP_571187
1516:NM_131112
1369:Orthologs
1364:Orthologs
1267:-binding
1185:NP_038661
1150:NP_976034
1146:NP_002692
1114:NM_013633
1089:NM_002701
1073:NM_203289
877:Orthologs
706:cytoplasm
173:GeneCards
41:October 3
34:October 4
9055:MADS box
7195:Homeobox
7107:Hox-like
7101:protoHOX
5862:Estrogen
5857:Androgen
5711:Rev-ErbA
5249:bHLH-ZIP
5224:bHLH-COE
4763:Myogenin
4296:Archived
4252:15467907
4222:35018708
4214:15342930
4179:15105401
4144:12923055
4101:12841847
4058:12727846
4037:11891324
3984:11689681
3941:11099378
3912:11096094
3877:12892299
3686:Genomics
3605:12923055
3562:21603127
3554:15625129
3519:23740530
3511:16415856
3482:27609337
3474:16456133
3439:16793732
3400:23516214
3392:17205510
3351:21826175
3302:23662657
3294:17379765
3253:18239456
3212:18159219
3161:19777066
3121:PLOS ONE
3108:15513931
3064:35762231
3015:28953884
2958:19968627
2857:31708402
2798:18059259
2755:19203577
2706:18594515
2663:86129154
2655:18029452
2612:18371336
2563:17554336
2512:17554338
2457:21663792
2397:15882627
2356:15860457
2304:15749924
2263:12727846
2228:15882627
2187:30287838
2130:25408886
2071:12528890
2021:33012290
2013:10742100
1975:16153702
1840:–
1819:–
1772:Enhancer
1765:See also
1751:in vitro
1722:such as
1713:G1 phase
1700:promoter
1693:in vitro
1614:endoderm
1386:Location
1233:Wikidata
856:Sources:
516:epiblast
478:testicle
9455:RUNX1T1
9435:CBFA2T3
9430:CBFA2T2
9310:TCF/LEF
7419:NK-like
7413:metaHOX
7116:ParaHox
7057:domains
5748:COUP-TF
5222:Group F
5145:Group E
5078:Group D
4942:Group C
4892:Group B
4836:Paraxis
4701:Group A
4260:4646923
4092:1223663
4005:Bibcode
3869:9814708
3834:9368058
3799:8889549
3764:8567814
3735:8500351
3706:8088794
3677:7908264
3642:8353907
3634:1723621
3342:3145994
3203:2151746
3152:2747014
3129:Bibcode
3055:9303268
3006:5815497
2985:Bibcode
2949:2825734
2909:9528758
2848:6900749
2806:1705950
2763:1630949
2714:4318637
2686:Bibcode
2635:Bibcode
2627:Science
2571:4377572
2543:Bibcode
2492:Bibcode
2448:5603300
2405:1913872
2312:1395518
2236:1913872
2178:6172215
2157:Bibcode
2121:4230828
2079:2982527
1966:3006442
1926:1408763
1842:Ensembl
1821:Ensembl
1777:Histone
1433:(human)
1402:(mouse)
1377:Species
1352:, lose
1333:in the
1294:of the
1281:protein
1265:octamer
1015:UniProt
944:Ensembl
883:Species
862:QuickGO
726:nucleus
711:cytosol
548:ooblast
403:pattern
261:6p21.33
129:Aliases
8168:Bicoid
7433:BARHL2
7428:BARHL1
7010:JMJD1B
6923:HIVEP1
5408:I-SMAD
5376:R-SMAD
5294:MLXIPL
5049:Period
4975:ARNTL2
4780:NeuroD
4288:POU5F1
4281:(MeSH)
4258:
4250:
4220:
4212:
4177:
4142:
4135:196258
4132:
4099:
4089:
4056:
4035:
4028:122580
4025:
3982:
3972:
3939:
3910:
3875:
3867:
3832:
3797:
3762:
3733:
3704:
3675:
3640:
3632:
3603:
3596:196258
3593:
3560:
3552:
3517:
3509:
3480:
3472:
3437:
3398:
3390:
3349:
3339:
3300:
3292:
3251:
3210:
3200:
3159:
3149:
3106:
3062:
3052:
3013:
3003:
2977:Nature
2956:
2946:
2907:
2900:121416
2897:
2855:
2845:
2804:
2796:
2761:
2753:
2712:
2704:
2678:Nature
2661:
2653:
2610:
2569:
2561:
2535:Nature
2520:459050
2518:
2510:
2484:Nature
2455:
2445:
2403:
2395:
2354:
2310:
2302:
2261:
2234:
2226:
2185:
2175:
2128:
2118:
2077:
2069:
2019:
2011:
1973:
1963:
1924:
1917:334192
1914:
1670:, and
1543:Domain
1505:303333
1474:294562
1335:oocyte
1315:POU5F1
1308:marker
1285:POU5F1
1273:POU5F1
1219:search
1217:PubMed
1048:P20263
1029:Q01860
899:Entrez
574:BioGPS
536:zygote
528:morula
524:morula
520:embryo
486:fundus
177:POU5F1
161:101893
153:164177
136:POU5F1
49:POU5F1
9718:Sigma
9583:EREBP
9567:EREBP
9558:(0.5)
9527:(0.3)
9450:RUNX3
9445:RUNX2
9440:RUNX1
9384:TFCP2
9305:SSRP1
9126:(4.7)
9116:TBPL1
9100:(4.6)
9052:(4.4)
8902:(4.2)
8843:NFKB2
8838:NFKB1
8833:NF-κB
8822:(4.1)
8746:MYBL2
8533:(3.4)
8229:(3.3)
8178:BICD2
8153:SHOX2
8121:PROP1
8105:PRRX
8015:SATB2
7960:BRN-3
7955:PIT-1
7847:PKNOX
7762:TALE
7758:NOBOX
7731:HESX1
7704:CUTL1
7686:other
7580:NANOG
7443:BARX2
7438:BARX1
7190:MEOX2
7185:MEOX1
7069:(3.1)
6978:JARID
6951:GRLF1
6946:DIDO1
6606:Zbtb7
6596:TSHZ3
6564:PRDM9
6362:HIVEP
6227:ATBF1
6181:TFIIH
6166:TFIIF
6149:TFIIE
6144:TFIID
6139:TFIIB
6134:TFIIA
6104:TRPS1
5970:LRH-1
5948:NURR1
5938:NGFIB
5766:Ear-2
5567:(2.1)
5309:SREBP
5246:(1.3)
5008:NPAS
4997:EPAS1
4982:CLOCK
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4944:bHLH-
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4915:l-Myc
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4900:FIGLA
4882:Twist
4841:TCF15
4748:MESP2
4726:ATOH1
4719:ASCL2
4714:ASCL1
4645:NFIL3
4576:GABPA
4571:DDIT3
4502:C/EBP
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4458:c-Jun
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4443:FOSL1
4433:c-Fos
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4218:S2CID
3975:99954
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3638:S2CID
3558:S2CID
3515:S2CID
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6549:MTF1
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4819:OLIG
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181:OMA
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9755::
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