325:
302:
655:
835:
29:
522:. In especially sensitive persons, even standard doses of olaflur can cause irritation. Like other fluoride salts, olaflur is toxic when given in high doses over an extended period of time. Especially in children, before the development of the
645:
is added to give the end product. Because olaflur is produced from a mixture of fatty acids, some molecules have side chains that are longer or shorter than 18 carbon atoms. Other byproducts of the reaction include hydroxyethyl
792:
MĂĽller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?".
833:, Heckendorn R, Gosteli J, "N-Alkyldiethanolamine hydrofluorides and oral hygiene compositions containing them", published 2001-07-05, assigned to GABA International AG
530:, a discolouring and weakening of the enamel. In acute cases of overdosage, for example when an olaflur containing preparation is swallowed, calcium in any oral form serves as an
866:
114:
458:
573:
properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral,
51:
414:
765:
Abanto
Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management".
859:
690:
Ganss C, Klimek J, Brune V, SchĂĽrmann A (2004). "Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ".
749:
852:
442:
InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H
650:
resulting from addition of ethylene oxide to the free hydroxyl groups. The presence of these side products is clinically irrelevant.
479:
434:
400:
172:
144:
1156:
261:
281:
914:
1141:
671:
966:
951:
87:
320:
622:
153:
830:
946:
546:
is practically insoluble in water, calcium-containing drugs and food inhibit the action of olaflur.
297:
196:
1146:
715:
69:
585:, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.
490:-containing substance that is an ingredient of toothpastes and solutions for the prevention of
1046:
991:
956:
809:
774:
745:
707:
642:
498:, it is also used in the form of gels for the treatment of early stages of caries, sensitive
1036:
971:
919:
801:
699:
666:
543:
527:
337:
270:
250:
1151:
909:
574:
523:
205:
324:
301:
1061:
1056:
941:
875:
638:
1135:
1080:
1070:
1001:
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491:
313:
844:
719:
1041:
1026:
961:
879:
602:
578:
507:
127:
122:
61:
230:
1116:
1111:
1106:
1031:
1011:
996:
976:
891:
654:
566:
519:
499:
1120:
1006:
986:
933:
614:
598:
570:
563:
559:
376:
241:
98:
1096:
1016:
929:
899:
744:(in German) (2009/2010 ed.). Vienna: Ă–sterreichischer Apothekerverlag.
582:
495:
102:
55:
813:
778:
711:
1075:
1021:
531:
487:
20:
1101:
981:
503:
216:
94:
805:
703:
888:
594:
28:
647:
618:
555:
399:
390:
494:. It has been in use since 1966. Especially in combination with
848:
637:-alkyl-1,3-propanediamines. The two nitrogen atoms react with
106:
286:
465:
534:. Often milk is used because it is usually at hand.
1089:
1055:
928:
887:
388:
375:
336:
331:
312:
280:
260:
240:
215:
195:
163:
143:
138:
113:
86:
68:
50:
40:
35:
45:{3-propyl}bis(2-hydroxyethyl)amine dihydrofluoride
581:. The fluoridation reaches only a depth of a few
229:
204:
735:
733:
731:
729:
593:The synthesis of olaflur starts from cattle's
860:
767:Medicina Oral, Patologia Oral y Cirugia Bucal
187:-octadecylpropane-1,3-diamine dihydrofluoride
8:
825:
823:
19:
867:
853:
845:
617:, and then converted to the corresponding
323:
300:
249:
269:
633:, followed by another reduction, yields
422:F.F.OCCN(CCCN(CCCCCCCCCCCCCCCCCC)CCO)CCO
682:
439:
419:
296:
177:
629:(largely octadecylamine). Addition of
518:Overdosage leads to irritation of the
314:
18:
577:, are converted into the more robust
60:
7:
126:
554:Olaflur is a salt consisting of an
220:
641:to form tertiary amines. Finally,
506:for the refluoridation of damaged
14:
550:Chemistry and mechanism of action
653:
360:
354:
348:
27:
447:Key:ZVVSSOQAYNYNPP-UHFFFAOYSA-N
366:
342:
1:
558:cation and fluoride as the
1173:
915:Sodium monofluorophosphate
332:Chemical and physical data
740:Haberfeld H, ed. (2009).
672:Remineralisation of teeth
526:, overdosage can lead to
455:
430:
410:
168:
26:
967:Cetylpyridinium chloride
62:International Drug Names
613:COOH), are obtained by
569:chain, the cation has
183:-tris(2-hydroxyethyl)-
831:US patent 6464962
625:catalytically to the
1157:Cationic surfactants
1102:Acetylsalicylic acid
947:Benzoxonium chloride
621:, which in turn are
79:No adequate studies
23:
484:amine fluoride 297
1129:
1128:
1047:Tibezonium iodide
992:Hydrogen peroxide
957:Chlortetracycline
920:Stannous fluoride
806:10.1021/la102325e
751:978-3-85200-196-8
704:10.1159/000080587
643:hydrofluoric acid
473:
472:
401:Interactive image
282:CompTox Dashboard
152:In general:
46:
16:Chemical compound
1164:
1142:Dental materials
1037:Sodium perborate
972:Domiphen bromide
869:
862:
855:
846:
840:
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783:
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737:
724:
723:
687:
667:Fluoride therapy
657:
597:. The contained
544:calcium fluoride
528:dental fluorosis
469:
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403:
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154:Over-the-counter
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1062:Glucocorticoids
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1057:Corticosteroids
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924:
910:Sodium fluoride
883:
873:
843:
836:
829:
828:
821:
800:(24): 18750–9.
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739:
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692:Caries Research
689:
688:
684:
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612:
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591:
575:hydroxylapatite
552:
540:
524:permanent teeth
516:
464:
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459:(what is this?)
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1076:Hydrocortisone
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1024:
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1004:
999:
994:
989:
984:
979:
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944:
942:Amphotericin B
938:
936:
926:
925:
923:
922:
917:
912:
907:
902:
896:
894:
885:
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878:preparations (
876:Stomatological
874:
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871:
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819:
784:
757:
750:
725:
681:
679:
676:
675:
674:
669:
662:
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639:ethylene oxide
627:primary amines
610:
606:
590:
587:
562:. With a long
556:alkyl ammonium
551:
548:
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512:
471:
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1081:Triamcinolone
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1077:
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1071:Dexamethasone
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1003:
1002:Metronidazole
1000:
998:
995:
993:
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988:
985:
983:
980:
978:
975:
973:
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968:
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960:
958:
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953:
952:Chlorhexidine
950:
948:
945:
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811:
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788:
785:
780:
776:
773:(2): E103-7.
772:
768:
761:
758:
753:
747:
743:
742:Austria-Codex
736:
734:
732:
730:
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721:
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670:
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651:
649:
644:
640:
636:
632:
631:acrylonitrile
628:
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620:
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586:
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572:
568:
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561:
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545:
537:
535:
533:
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521:
513:
511:
509:
505:
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497:
493:
492:dental caries
489:
485:
481:
477:
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395:
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341:
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326:
322:
319:
317:
315:ECHA InfoCard
311:
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57:
53:
49:
43:
39:
36:Clinical data
34:
30:
25:
1042:Tetracycline
1027:Oxyquinoline
962:Clotrimazole
904:
797:
793:
787:
770:
766:
760:
741:
698:(6): 561–6.
695:
691:
685:
652:
634:
603:stearic acid
592:
579:fluorapatite
553:
541:
538:Interactions
517:
508:tooth enamel
483:
475:
474:
463:
457:
184:
180:
145:Legal status
139:Legal status
1117:Epinephrine
1112:Benzydamine
1107:Becaplermin
1032:Polynoxylin
1012:Minocycline
997:Mepartricin
977:Doxycycline
934:antiseptics
892:prophylaxis
599:fatty acids
567:hydrocarbon
520:oral mucosa
384: g·mol
321:100.027.174
164:Identifiers
41:Other names
1136:Categories
1121:Adrenalone
1007:Miconazole
987:Hexetidine
678:References
615:hydrolysis
583:nanometres
571:surfactant
564:lipophilic
560:counterion
514:Overdosage
389:3D model (
377:Molar mass
271:8NY9L8837D
242:ChemSpider
197:CAS Number
173:IUPAC name
99:toothpaste
1147:Fluorides
1097:Amlexanox
1017:Natamycin
930:Infection
900:Dectaflur
601:, mainly
589:Synthesis
502:, and by
496:dectaflur
206:6818-37-7
103:mouthwash
88:Routes of
70:Pregnancy
56:Drugs.com
1022:Neomycin
814:21090577
794:Langmuir
779:19179949
720:12683542
712:15528912
661:See also
542:Because
532:antidote
504:dentists
488:fluoride
466:(verify)
115:ATC code
72:category
982:Eugenol
905:Olaflur
623:reduced
486:) is a
476:Olaflur
382:498.785
338:Formula
217:PubChem
131:)
125: (
123:A01AA03
95:Topical
21:Olaflur
1152:Amines
889:Caries
837:
812:
777:
748:
718:
710:
648:ethers
619:amides
595:tallow
415:SMILES
181:N,N,N'
1090:Other
716:S2CID
500:teeth
482:, or
435:InChI
391:JSmol
251:21751
231:23257
156:(OTC)
932:and
810:PMID
775:PMID
746:ISBN
708:PMID
262:UNII
52:AHFS
880:A01
802:doi
700:doi
480:INN
287:EPA
221:CID
128:WHO
107:gel
1138::
822:^
808:.
798:26
796:.
771:14
769:.
728:^
714:.
706:.
696:38
694:.
611:35
607:17
605:(C
510:.
352:60
346:27
185:N'
105:,
101:,
1119:/
1064:)
1060:(
882:)
868:e
861:t
854:v
816:.
804::
781:.
754:.
722:.
702::
635:N
609:H
478:(
393:)
370:3
367:O
364:2
361:N
358:2
355:F
349:H
343:C
289:)
285:(
109:)
97:(
54:/
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