515:
on the methotrexate exposure is not expected with their simultaneous use. According to the results of the CREDO1β3 clinical trials, no cases of clinically significant drug interactions of olokizumab with other drugs were reported. In an in vitro study on human cryopreserved hepatocytes, olokizumab reversed the inhibitory effect of IL-6 on CYP1A1/2, 2B6, 2C9, 3A4/5 and 2C19 activity, as well as on NTCP activity. Thus, it should be considered that in patients with active rheumatoid arthritis, dose adjustment of drugs metabolized by these CYP isoforms may be necessary after beginning the treatment with olokizumab.
311:(IL-6). IL-6 is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases. Olokizumab is the first interleukin-6 (IL-6) inhibitor approved for treatment of rheumatoid arthritis which blocks directly cytokine instead of its receptor. Olokizumab specifically binds to IL-6 at Site 3, blocking IL-6 ability to form hexameric complex. Olokizumab was developed by
454:
363:
945:
4774:
514:
In all clinical trials in patients with rheumatoid arthritis, olokizumab was used in conjunction with methotrexate. Special clinical studies of drug interactions of olokizumab have not been conducted. Concomitant use with methotrexate did not affect the olokizumab exposure. The effect of olokizumab
518:
The concentration of the following drugs may decrease when used together with olokizumab (including, but not limited to): statins (simvastatin, lovastatin, atorvastatin); oral contraceptives; calcium channel blockers; glucocorticoids (dexamethasone, methylprednisolone); warfarin; quinidine;
907:
for "A Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Tumor Necrosis Factor Alpha (TNF-Ξ±) Inhibitor Therapy" at
328:
Olokizumab was approved for medical use in Russia, Kazakhstan, Belarus, Kirgizstan and
Azerbaijan under the brand name Artlegia for treatment of patients aged 18 years or older with moderate to severe rheumatoid arthritis in combination with methotrexate who have an inadequate response to
527:
Olokizumab efficacy and safety were studied as part of a large-scale program of clinical trials, CREDO, which included 2,444 adult patients with rheumatoid arthritis from 19 countries worldwide. The study of olokizumab continues in the general, open-label, long-term extension.
541:
for "A Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multicenter Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate Therapy" at
820:"Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study"
801:
for "A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate Therapy" at
549:
CREDO 3. Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Tumor Necrosis Factor Alpha (TNF-Ξ±) Inhibitor Therapy.
534:
CREDO 2. Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate Therapy.Clinical trial number
3509:
2444:
531:
CREDO 1. Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate Therapy.
95:
279:
737:
Mahmoud AM (2023). "Olokizumab's
Effectiveness and Safety in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials".
519:
theophylline; tizanidine; phenytoin; pimozide; cyclosporine; sirolimus; tacrolimus; benzodiazepines (e.g., diazepam, alprazolam, triazolam, midazolam, bromazepam).
867:
Smolen JS, Feist E, Fatenejad S, Grishin SA, Korneva EV, Nasonov EL, et al. (August 2022). "Olokizumab versus
Placebo or Adalimumab in Rheumatoid Arthritis".
926:
for "A Multicenter, Open-Label, Phase III Study of the
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis" at
3502:
1002:
2437:
36:
3495:
1918:
4707:
3974:
2430:
4711:
4697:
4657:
3453:
4726:
553:
CREDO 4. Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis.
4631:
3579:
1861:
1231:
501:
410:
995:
772:
663:
2270:
623:[The prospects of interleukin-6 inhibition in rheumatoid arthritis: Olokizumab (novel monoclonal antibodies to IL-6)].
433:
334:
4794:
3425:
479:
388:
349:
in patients with moderate to severe new coronavirus infection (COVID-19) was approved in Russia, Kirgizstan and Azerbaijan.
4592:
4571:
690:"The efficacy and safety of olokizumab for rheumatoid arthritis: a systematic review, pairwise, and network meta-analysis"
572:"The efficacy and safety of olokizumab for rheumatoid arthritis: a systematic review, pairwise, and network meta-analysis"
3435:
1067:
202:
3470:
1176:
988:
475:
384:
4764:
1046:
621:"ΠΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΈΠΈ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6 ΠΏΡΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠΌ Π°ΡΡΡΠΈΡΠ΅: ΠΎΠ»ΠΎΠΊΠΈΠ·ΡΠΌΠ°Π± (Π½ΠΎΠ²ΡΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΠΠ-6)"
3019:
1724:
346:
251:
2104:
464:
373:
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2099:
483:
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83:
4125:
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1904:
1330:
1011:
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2091:
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4530:
3518:
2735:
980:
688:
Abuelazm M, Ghanem A, Mahmoud A, Brakat AM, Elzeftawy MA, Mamdouh Fayoud A, et al. (June 2023).
570:
Abuelazm M, Ghanem A, Mahmoud A, Brakat AM, Elzeftawy MA, Mamdouh Fayoud A, et al. (June 2023).
300:
128:
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1312:
146:
46:
29:
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2301:
2159:
954:
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3731:
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3554:
2311:
1997:
1438:
818:
Feist E, Fatenejad S, Grishin S, Korneva E, Luggen ME, Nasonov E, et al. (December 2022).
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3889:
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2256:
1057:
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884:
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719:
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73:
155:
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2062:
1965:
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876:
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120:
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2119:
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1601:
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1200:
1037:
844:
819:
299:
sold under the name Artlegia, is an immunosuppressive drug, used for the treatment of
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4130:
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1934:
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308:
61:
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2017:
2012:
1992:
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330:
108:
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2002:
1987:
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2022:
2007:
1950:
1945:
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186:
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723:
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22:
880:
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2703:
2626:
2536:
2506:
2321:
2196:
1885:
1393:
1303:
1239:
1161:
424:
A history of hypersensitivity to olokizumab or any component of the drug.
304:
166:
175:
4693:
4176:
3180:
3065:
1814:
312:
56:
4308:
3405:
2129:
1960:
242:
231:
4615:
4611:
4607:
4226:
4222:
4206:
1828:
1681:
1800:
1748:
1709:
1695:
1249:
1123:
222:
3491:
2426:
984:
4683:
1657:
447:
356:
345:
Olokizumab was approved for pathogenesis-based therapy of
286:
4762:
427:
Active infectious diseases (including tuberculosis).
307:. It is a humanized monoclonal antibody against the
4667:
4647:
4640:
4591:
4570:
4549:
4509:
4488:
4432:
4400:
4359:
4317:
4271:
4190:
4164:
4108:
4067:
4041:
4015:
3984:
3964:
3943:
3862:
3801:
3745:
3699:
3623:
3528:
3413:
3403:
3383:
3312:
3246:
3237:
3206:
2878:
2810:
2744:
2473:
2464:
2189:
2117:
2090:
1975:
1618:
1320:
1311:
1302:
1295:
1248:
1230:
1221:
1175:
1106:
1036:
1027:
266:
261:
241:
221:
201:
185:
165:
145:
140:
127:
119:
94:
82:
72:
67:
55:
45:
35:
28:
666:[State register of medicinal products].
154:
773:"ΠΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅Π΅ΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ²"
664:"ΠΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅Π΅ΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ²"
3503:
2438:
996:
8:
813:
811:
21:
482:. Unsourced material may be challenged and
391:. Unsourced material may be challenged and
4644:
3510:
3496:
3488:
3410:
3243:
2470:
2445:
2431:
2423:
1317:
1308:
1299:
1227:
1033:
1003:
989:
981:
843:
713:
636:
595:
502:Learn how and when to remove this message
411:Learn how and when to remove this message
210:
4675:Interleukin 14 (taxilin alpha, HMW-BCGF)
4769:
562:
174:
3973:See CXCR1 (IL-8RΞ±) and CXCR2 (IL-8RΞ²)
658:
656:
20:
250:
7:
976:. U.S. National Library of Medicine.
480:adding citations to reliable sources
389:adding citations to reliable sources
107:
869:The New England Journal of Medicine
230:
619:Nasonov EL, Feist E (2022-11-10).
14:
625:Rheumatology Science and Practice
4772:
943:
824:Annals of the Rheumatic Diseases
739:Journal of Clinical Densitometry
452:
361:
4501:Interleukin 27 (interleukin 30)
638:10.47360/1995-4484-2022-505-518
434:Hereditary fructose intolerance
430:Children under 18 years of age.
335:tumor necrosis factor inhibitor
1:
436:(the drug contains sorbitol).
1068:dihydroorotate dehydrogenase
315:, and was launched in 2020.
3851:Antisense oligonucleotides:
1047:purine synthesis inhibitors
4811:
751:10.1016/j.jocd.2022.12.003
706:10.1007/s10067-023-06519-6
588:10.1007/s10067-023-06519-6
262:Chemical and physical data
3448:
1232:IL-1 receptor antagonists
347:cytokine release syndrome
276:
2105:Anti-lymphocyte globulin
4541:Interleukin-29 (IFN-Ξ»1)
3686:Daclizumab (dacliximab)
3671:Tucotuzumab celmoleukin
2100:Anti-thymocyte globulin
1012:Immunosuppressive drugs
974:Drug Information Portal
836:10.1136/ard-2022-222630
4522:Interferon Ξ»4 (IFN-Ξ»4)
3615:Rilonacept (IL-1 Trap)
1905:Interleukin-6 receptor
1331:Complement component 5
920:Clinical trial number
901:Clinical trial number
795:Clinical trial number
4795:Monoclonal antibodies
4445:Interleukin 23 (SGRF)
4126:Cintredekin besudotox
4054:Interleukin 11 (AGIF)
4033:Interleukin 10 (CSIF)
2532:Camidanlumab tesirine
2454:Monoclonal antibodies
881:10.1056/NEJMoa2201302
694:Clinical Rheumatology
576:Clinical Rheumatology
3519:Interleukin receptor
3207:Chimeric + humanized
2736:Nivolumab/relatlimab
476:improve this section
385:improve this section
324:Rheumatoid arthritis
301:rheumatoid arthritis
3651:Denileukin diftitox
777:grls.rosminzdrav.ru
668:grls.rosminzdrav.ru
252:ChEMBLCHEMBL1743050
30:Monoclonal antibody
25:
16:Monoclonal antibody
4223:E (interleukin 25)
3475:Never to phase III
2921:Certolizumab pegol
2888:Immunosuppressive:
2262:Diroximel fumarate
1935:IL-2 receptor/CD25
1363:Certolizumab pegol
1016:Immunosuppressants
953:has a profile for
928:ClinicalTrials.gov
910:ClinicalTrials.gov
804:ClinicalTrials.gov
544:ClinicalTrials.gov
4760:
4759:
4756:
4755:
4725:(signals through
4706:(signals through
4692:(signals through
4682:(signals through
4306:Binding proteins:
3636:Adargileukin alfa
3485:
3484:
3444:
3443:
3399:
3398:
3233:
3232:
3188:Immune activation
2680:Immune activation
2482:Immunosuppression
2420:
2419:
2267:Efgartigimod alfa
2257:Dimethyl fumarate
2185:
2184:
2113:
2112:
2086:
2085:
1291:
1290:
1217:
1216:
1058:Mycophenolic acid
959:
830:(12): 1661β1668.
512:
511:
504:
444:Drug interactions
421:
420:
413:
353:Contraindications
294:
293:
4802:
4777:
4776:
4775:
4768:
4748:Efineptakin alfa
4743:Efavaleukin alfa
4645:
3612:Decoy receptors:
3512:
3505:
3498:
3489:
3411:
3244:
2802:Zolimomab aritox
2792:Telimomab aritox
2471:
2447:
2440:
2433:
2424:
2063:Telimomab aritox
1966:Zolimomab aritox
1787:CD62L/L-selectin
1525:Immunoglobulin E
1318:
1309:
1300:
1228:
1034:
1005:
998:
991:
982:
977:
957:
947:
946:
930:
918:
912:
899:
893:
892:
864:
858:
857:
847:
815:
806:
793:
787:
786:
784:
783:
769:
763:
762:
734:
728:
727:
717:
700:(6): 1503β1520.
685:
679:
678:
676:
675:
660:
651:
650:
640:
616:
610:
609:
599:
582:(6): 1503β1520.
567:
507:
500:
496:
493:
487:
456:
448:
416:
409:
405:
402:
396:
365:
357:
337:(TNFi) therapy.
297:Olokizumab (OKZ)
290:
289:
282:
254:
234:
214:
178:
158:
132:
111:
26:
24:
4810:
4809:
4805:
4804:
4803:
4801:
4800:
4799:
4785:
4784:
4783:
4773:
4771:
4763:
4761:
4752:
4663:
4636:
4587:
4566:
4545:
4505:
4484:
4428:
4425:(against IL-22)
4396:
4355:
4352:(against IL-20)
4313:
4267:
4186:
4160:
4104:
4063:
4037:
4011:
3980:
3960:
3939:
3858:
3797:
3741:
3695:
3619:
3524:
3516:
3486:
3481:
3480:
3465:Clinical trials
3440:
3395:
3379:
3308:
3229:
3220:Rozanolixizumab
3208:
3202:
3194:
3183:
2996:Lulizumab pegol
2874:
2806:
2740:
2460:
2451:
2421:
2416:
2362:Rozanolixizumab
2247:Deucravacitinib
2181:
2109:
2082:
1971:
1620:
1614:
1322:
1287:
1244:
1223:
1213:
1171:
1111:
1102:
1038:Antimetabolites
1029:
1023:
1009:
968:
965:
964:
963:
948:
944:
939:
934:
933:
919:
915:
900:
896:
866:
865:
861:
817:
816:
809:
794:
790:
781:
779:
771:
770:
766:
736:
735:
731:
687:
686:
682:
673:
671:
662:
661:
654:
618:
617:
613:
569:
568:
564:
559:
525:
508:
497:
491:
488:
473:
457:
446:
417:
406:
400:
397:
382:
366:
355:
343:
326:
321:
285:
283:
280:(what is this?)
277:
257:
237:
217:
197:
181:
161:
130:
121:Pharmacokinetic
115:
85:
17:
12:
11:
5:
4808:
4806:
4798:
4797:
4787:
4786:
4782:
4781:
4758:
4757:
4754:
4753:
4751:
4750:
4745:
4736:
4735:
4733:Interleukin 35
4730:
4723:Interleukin 34
4720:
4718:Interleukin 32
4715:
4704:Interleukin 26
4701:
4690:Interleukin 24
4687:
4680:Interleukin 16
4677:
4671:
4669:
4665:
4664:
4662:
4661:
4653:
4651:
4642:
4638:
4637:
4635:
4634:
4625:
4624:
4622:Interleukin 38
4619:
4604:Interleukin 36
4597:
4595:
4589:
4588:
4586:
4585:
4583:Interleukin 33
4576:
4574:
4568:
4567:
4565:
4564:
4562:Interleukin 31
4555:
4553:
4547:
4546:
4544:
4543:
4538:
4527:Interleukin 28
4524:
4515:
4513:
4507:
4506:
4504:
4503:
4494:
4492:
4486:
4485:
4483:
4482:
4477:
4472:
4467:
4462:
4457:
4448:
4447:
4438:
4436:
4430:
4429:
4427:
4426:
4416:
4415:
4413:Interleukin 22
4406:
4404:
4398:
4397:
4395:
4394:
4389:
4380:
4379:
4377:Interleukin 21
4374:
4365:
4363:
4357:
4356:
4354:
4353:
4343:
4342:
4340:Interleukin 24
4337:
4335:Interleukin 20
4332:
4330:Interleukin 19
4323:
4321:
4315:
4314:
4312:
4311:
4302:
4301:
4296:
4294:Interleukin 37
4291:
4289:Interleukin 18
4286:
4277:
4275:
4269:
4268:
4266:
4265:
4260:
4255:
4250:
4245:
4240:
4231:
4230:
4203:Interleukin 17
4196:
4194:
4188:
4187:
4185:
4184:
4182:Interleukin 15
4179:
4170:
4168:
4162:
4161:
4159:
4158:
4153:
4148:
4139:
4138:
4136:Interleukin 13
4133:
4128:
4123:
4114:
4112:
4106:
4105:
4103:
4102:
4097:
4088:
4087:
4085:Interleukin 12
4082:
4073:
4071:
4065:
4064:
4062:
4061:
4056:
4047:
4045:
4039:
4038:
4036:
4035:
4030:
4021:
4019:
4013:
4012:
4010:
4009:
4000:
3999:
3990:
3988:
3982:
3981:
3979:
3978:
3970:
3968:
3962:
3961:
3959:
3958:
3949:
3947:
3941:
3940:
3938:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3883:
3882:
3877:
3868:
3866:
3860:
3859:
3857:
3856:
3847:
3846:
3841:
3836:
3827:
3826:
3817:
3816:
3807:
3805:
3799:
3798:
3796:
3795:
3790:
3781:
3780:
3771:
3770:
3768:Interleukin 13
3765:
3760:
3751:
3749:
3743:
3742:
3740:
3739:
3737:Promegapoietin
3734:
3729:
3724:
3719:
3714:
3705:
3703:
3697:
3696:
3694:
3693:
3688:
3683:
3674:
3673:
3668:
3663:
3661:Pegaldesleukin
3658:
3653:
3648:
3643:
3638:
3629:
3627:
3621:
3620:
3618:
3617:
3608:
3607:
3602:
3597:
3588:
3587:
3582:
3577:
3572:
3563:
3562:
3557:
3552:
3534:
3532:
3526:
3525:
3517:
3515:
3514:
3507:
3500:
3492:
3483:
3482:
3479:
3478:
3477:
3476:
3473:
3462:
3456:
3450:
3449:
3446:
3445:
3442:
3441:
3439:
3438:
3433:
3428:
3423:
3417:
3415:
3408:
3401:
3400:
3397:
3396:
3394:
3393:
3387:
3385:
3381:
3380:
3378:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3316:
3314:
3310:
3309:
3307:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3250:
3248:
3241:
3235:
3234:
3231:
3230:
3228:
3227:
3222:
3217:
3211:
3209:
3204:
3203:
3185:
3184:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3020:+hyaluronidase
3013:
3008:
3003:
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2884:
2882:
2876:
2875:
2873:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2816:
2814:
2808:
2807:
2805:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2748:
2746:
2742:
2741:
2739:
2738:
2728:
2727:
2722:
2717:
2707:
2706:
2701:
2696:
2691:
2686:
2676:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2477:
2475:
2468:
2462:
2461:
2452:
2450:
2449:
2442:
2435:
2427:
2418:
2417:
2415:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2271:+hyaluronidase
2264:
2259:
2254:
2252:Deuruxolitinib
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2214:
2209:
2204:
2199:
2193:
2191:
2187:
2186:
2183:
2182:
2180:
2179:
2174:
2169:
2164:
2163:
2162:
2157:
2145:
2144:
2143:
2138:
2125:
2123:
2115:
2114:
2111:
2110:
2108:
2107:
2102:
2096:
2094:
2088:
2087:
2084:
2083:
2081:
2080:
2075:
2070:
2065:
2060:
2055:
2050:
2045:
2040:
2035:
2030:
2025:
2020:
2015:
2010:
2005:
2000:
1995:
1990:
1985:
1979:
1977:
1973:
1972:
1970:
1969:
1956:
1955:
1954:
1953:
1948:
1943:
1930:
1929:
1928:
1927:
1915:
1914:
1913:
1901:
1900:
1899:
1894:
1882:
1881:
1880:
1875:
1870:
1858:
1857:
1856:
1845:
1844:
1843:
1842:
1837:
1825:
1824:
1823:
1811:
1810:
1809:
1797:
1796:
1795:
1783:
1782:
1781:
1776:
1764:
1763:
1762:
1757:
1745:
1744:
1743:
1738:
1733:
1728:
1725:+hyaluronidase
1718:
1706:
1705:
1704:
1692:
1691:
1690:
1678:
1677:
1676:
1671:
1666:
1654:
1653:
1652:
1647:
1642:
1637:
1624:
1622:
1616:
1615:
1613:
1612:
1611:
1610:
1597:
1596:
1595:
1594:
1589:
1568:
1567:
1566:
1565:
1552:
1551:
1550:
1549:
1536:
1535:
1534:
1533:
1520:
1519:
1518:
1517:
1504:
1503:
1502:
1501:
1496:
1491:
1486:
1481:
1476:
1471:
1466:
1461:
1456:
1451:
1446:
1441:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1401:
1396:
1383:
1382:
1381:
1380:
1375:
1370:
1365:
1360:
1355:
1342:
1341:
1340:
1339:
1326:
1324:
1315:
1306:
1297:
1293:
1292:
1289:
1288:
1286:
1285:
1280:
1275:
1270:
1265:
1260:
1254:
1252:
1246:
1245:
1243:
1242:
1236:
1234:
1225:
1219:
1218:
1215:
1214:
1212:
1211:
1210:
1209:
1201:PDE4 inhibitor
1197:
1192:
1187:
1181:
1179:
1173:
1172:
1170:
1169:
1164:
1158:
1157:
1156:
1155:
1150:
1145:
1140:
1119:
1117:
1104:
1103:
1101:
1100:
1099:
1098:
1085:
1084:
1083:
1082:
1077:
1063:
1062:
1061:
1060:
1055:
1042:
1040:
1031:
1025:
1024:
1010:
1008:
1007:
1000:
993:
985:
979:
978:
949:
942:
941:
940:
938:
937:External links
935:
932:
931:
913:
894:
875:(8): 715β726.
859:
807:
788:
764:
729:
680:
652:
631:(5): 505β518.
627:(in Russian).
611:
561:
560:
558:
555:
524:
521:
510:
509:
460:
458:
451:
445:
442:
441:
440:
437:
431:
428:
425:
419:
418:
369:
367:
360:
354:
351:
342:
339:
325:
322:
320:
317:
292:
291:
274:
273:
270:
264:
263:
259:
258:
256:
255:
247:
245:
239:
238:
236:
235:
227:
225:
219:
218:
216:
215:
207:
205:
199:
198:
196:
195:
191:
189:
183:
182:
180:
179:
171:
169:
163:
162:
160:
159:
151:
149:
143:
142:
138:
137:
134:
125:
124:
117:
116:
114:
113:
100:
98:
92:
91:
88:
86:administration
80:
79:
76:
70:
69:
65:
64:
59:
53:
52:
49:
43:
42:
41:Whole antibody
39:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
4807:
4796:
4793:
4792:
4790:
4780:
4770:
4766:
4749:
4746:
4744:
4741:
4738:
4737:
4734:
4731:
4728:
4724:
4721:
4719:
4716:
4713:
4709:
4705:
4702:
4699:
4695:
4691:
4688:
4685:
4681:
4678:
4676:
4673:
4672:
4670:
4666:
4659:
4655:
4654:
4652:
4650:
4646:
4643:
4639:
4633:
4630:
4627:
4626:
4623:
4620:
4617:
4613:
4609:
4605:
4602:
4599:
4598:
4596:
4594:
4590:
4584:
4581:
4578:
4577:
4575:
4573:
4569:
4563:
4560:
4557:
4556:
4554:
4552:
4548:
4542:
4539:
4536:
4532:
4528:
4525:
4523:
4520:
4517:
4516:
4514:
4512:
4508:
4502:
4499:
4496:
4495:
4493:
4491:
4487:
4481:
4478:
4476:
4475:Tildrakizumab
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4450:
4449:
4446:
4443:
4440:
4439:
4437:
4435:
4431:
4424:
4421:
4418:
4417:
4414:
4411:
4408:
4407:
4405:
4403:
4399:
4393:
4390:
4388:
4385:
4382:
4381:
4378:
4375:
4373:
4370:
4367:
4366:
4364:
4362:
4358:
4351:
4348:
4345:
4344:
4341:
4338:
4336:
4333:
4331:
4328:
4325:
4324:
4322:
4320:
4316:
4310:
4307:
4304:
4303:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4279:
4278:
4276:
4274:
4270:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4233:
4232:
4228:
4224:
4220:
4216:
4212:
4208:
4204:
4201:
4198:
4197:
4195:
4193:
4189:
4183:
4180:
4178:
4175:
4172:
4171:
4169:
4167:
4163:
4157:
4154:
4152:
4149:
4147:
4144:
4141:
4140:
4137:
4134:
4132:
4131:Interleukin 4
4129:
4127:
4124:
4122:
4119:
4116:
4115:
4113:
4111:
4107:
4101:
4098:
4096:
4093:
4090:
4089:
4086:
4083:
4081:
4080:Edodekin alfa
4078:
4075:
4074:
4072:
4070:
4066:
4060:
4057:
4055:
4052:
4049:
4048:
4046:
4044:
4040:
4034:
4031:
4029:
4026:
4023:
4022:
4020:
4018:
4014:
4008:
4005:
4002:
4001:
3998:
3997:Interleukin 9
3995:
3992:
3991:
3989:
3987:
3983:
3976:
3972:
3971:
3969:
3967:
3963:
3957:
3956:Interleukin 7
3954:
3951:
3950:
3948:
3946:
3942:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3885:
3884:
3881:
3880:Interleukin 6
3878:
3876:
3875:Atexakin alfa
3873:
3870:
3869:
3867:
3865:
3861:
3855:
3852:
3849:
3848:
3845:
3842:
3840:
3837:
3835:
3832:
3829:
3828:
3825:
3822:
3819:
3818:
3815:
3814:Interleukin 5
3812:
3809:
3808:
3806:
3804:
3800:
3794:
3791:
3789:
3786:
3783:
3782:
3779:
3776:
3773:
3772:
3769:
3766:
3764:
3763:Interleukin 4
3761:
3759:
3756:
3753:
3752:
3750:
3748:
3744:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3717:Interleukin 3
3715:
3713:
3710:
3707:
3706:
3704:
3702:
3698:
3692:
3689:
3687:
3684:
3682:
3679:
3676:
3675:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3656:Interleukin 2
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3631:
3630:
3628:
3626:
3622:
3616:
3613:
3610:
3609:
3606:
3603:
3601:
3598:
3596:
3593:
3590:
3589:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3565:
3564:
3561:
3558:
3556:
3553:
3550:
3546:
3542:
3541:Interleukin 1
3539:
3536:
3535:
3533:
3531:
3527:
3523:
3520:
3513:
3508:
3506:
3501:
3499:
3494:
3493:
3490:
3474:
3472:
3469:
3468:
3466:
3463:
3460:
3457:
3455:
3452:
3451:
3447:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3418:
3416:
3412:
3409:
3407:
3404:Inflammatory
3402:
3392:
3389:
3388:
3386:
3382:
3376:
3375:Tildrakizumab
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3317:
3315:
3311:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3251:
3249:
3245:
3242:
3240:
3236:
3226:
3223:
3221:
3218:
3216:
3213:
3212:
3210:
3205:
3201:
3200:
3197:
3193:
3189:
3182:
3179:
3177:
3176:Vobarilizumab
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3121:Spartalizumab
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3046:Pembrolizumab
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3021:
3017:
3014:
3012:
3009:
3007:
3006:Mogamulizumab
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2926:Crizanlizumab
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2886:
2885:
2883:
2881:
2877:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2820:Andecaliximab
2818:
2817:
2815:
2813:
2809:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2749:
2747:
2743:
2737:
2733:
2730:
2729:
2726:
2723:
2721:
2718:
2716:
2712:
2709:
2708:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2681:
2678:
2677:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2484:
2483:
2479:
2478:
2476:
2472:
2469:
2467:
2466:Immune system
2463:
2459:
2458:immune system
2455:
2448:
2443:
2441:
2436:
2434:
2429:
2428:
2425:
2413:
2410:
2408:
2405:
2403:
2402:Tildrakizumab
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2332:Pegcetacoplan
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2272:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2242:Darvadstrocel
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2194:
2192:
2188:
2178:
2175:
2173:
2170:
2168:
2165:
2161:
2158:
2156:
2153:
2152:
2151:
2150:
2149:TNF inhibitor
2146:
2142:
2139:
2137:
2134:
2133:
2132:
2131:
2127:
2126:
2124:
2121:
2116:
2106:
2103:
2101:
2098:
2097:
2095:
2093:
2089:
2079:
2076:
2074:
2071:
2069:
2066:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2046:
2044:
2041:
2039:
2036:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1980:
1978:
1974:
1967:
1963:
1962:
1958:
1957:
1952:
1949:
1947:
1944:
1942:
1939:
1938:
1937:
1936:
1932:
1931:
1926:
1923:
1922:
1921:
1920:
1916:
1912:
1909:
1908:
1907:
1906:
1902:
1898:
1895:
1893:
1890:
1889:
1888:
1887:
1883:
1879:
1876:
1874:
1871:
1869:
1866:
1865:
1864:
1863:
1859:
1855:
1852:
1851:
1850:
1847:
1846:
1841:
1838:
1836:
1833:
1832:
1831:
1830:
1826:
1822:
1819:
1818:
1817:
1816:
1815:CD147/Basigin
1812:
1808:
1805:
1804:
1803:
1802:
1798:
1794:
1791:
1790:
1789:
1788:
1784:
1780:
1777:
1775:
1772:
1771:
1770:
1769:
1765:
1761:
1758:
1756:
1753:
1752:
1751:
1750:
1746:
1742:
1739:
1737:
1734:
1732:
1729:
1726:
1722:
1719:
1717:
1714:
1713:
1712:
1711:
1707:
1703:
1700:
1699:
1698:
1697:
1693:
1689:
1686:
1685:
1684:
1683:
1679:
1675:
1672:
1670:
1667:
1665:
1662:
1661:
1660:
1659:
1655:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1635:Muromonab-CD3
1633:
1632:
1631:
1630:
1626:
1625:
1623:
1617:
1609:
1606:
1605:
1604:
1603:
1599:
1598:
1593:
1590:
1588:
1585:
1584:
1583:
1582:
1578:
1574:
1570:
1569:
1564:
1561:
1560:
1559:
1558:
1554:
1553:
1548:
1545:
1544:
1543:
1542:
1538:
1537:
1532:
1529:
1528:
1527:
1526:
1522:
1521:
1516:
1513:
1512:
1511:
1510:
1509:Interleukin 5
1506:
1505:
1500:
1497:
1495:
1492:
1490:
1489:Tildrakizumab
1487:
1485:
1482:
1480:
1477:
1475:
1472:
1470:
1467:
1465:
1462:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1397:
1395:
1392:
1391:
1390:
1389:
1385:
1384:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1361:
1359:
1356:
1354:
1351:
1350:
1349:
1348:
1344:
1343:
1338:
1335:
1334:
1333:
1332:
1328:
1327:
1325:
1323:(noncellular)
1319:
1316:
1314:
1310:
1307:
1305:
1301:
1298:
1296:Extracellular
1294:
1284:
1281:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1263:Ridaforolimus
1261:
1259:
1256:
1255:
1253:
1251:
1247:
1241:
1238:
1237:
1235:
1233:
1229:
1226:
1222:Intracellular
1220:
1208:
1205:
1204:
1203:
1202:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1182:
1180:
1178:
1174:
1168:
1165:
1163:
1160:
1159:
1154:
1151:
1149:
1146:
1144:
1141:
1139:
1136:
1135:
1134:
1133:
1129:
1125:
1121:
1120:
1118:
1115:
1109:
1105:
1097:
1094:
1093:
1092:
1091:
1087:
1086:
1081:
1080:Teriflunomide
1078:
1076:
1073:
1072:
1070:
1069:
1065:
1064:
1059:
1056:
1054:
1051:
1050:
1049:
1048:
1044:
1043:
1041:
1039:
1035:
1032:
1028:Intracellular
1026:
1021:
1017:
1013:
1006:
1001:
999:
994:
992:
987:
986:
983:
975:
971:
967:
966:
961:
960:
952:
936:
929:
925:
924:
917:
914:
911:
906:
905:
898:
895:
890:
886:
882:
878:
874:
870:
863:
860:
855:
851:
846:
841:
837:
833:
829:
825:
821:
814:
812:
808:
805:
800:
799:
792:
789:
778:
774:
768:
765:
760:
756:
752:
748:
744:
740:
733:
730:
725:
721:
716:
711:
707:
703:
699:
695:
691:
684:
681:
669:
665:
659:
657:
653:
648:
644:
639:
634:
630:
626:
622:
615:
612:
607:
603:
598:
593:
589:
585:
581:
577:
573:
566:
563:
556:
554:
551:
547:
546:</ref>
545:
540:
539:
532:
529:
522:
520:
516:
506:
503:
495:
485:
481:
477:
471:
470:
466:
461:This section
459:
455:
450:
449:
443:
439:Breastfeeding
438:
435:
432:
429:
426:
423:
422:
415:
412:
404:
394:
390:
386:
380:
379:
375:
370:This section
368:
364:
359:
358:
352:
350:
348:
340:
338:
336:
332:
323:
318:
316:
314:
313:R-Pharm group
310:
309:interleukin-6
306:
302:
298:
288:
281:
275:
271:
269:
265:
260:
253:
249:
248:
246:
244:
240:
233:
229:
228:
226:
224:
220:
213:
209:
208:
206:
204:
200:
193:
192:
190:
188:
184:
177:
173:
172:
170:
168:
164:
157:
153:
152:
150:
148:
144:
139:
135:
133:
126:
122:
118:
110:
105:
102:
101:
99:
97:
93:
89:
87:
81:
77:
75:
71:
68:Clinical data
66:
63:
60:
58:
54:
50:
48:
44:
40:
38:
34:
31:
27:
19:
4739:
4727:M-CSFR/CSF1R
4714:heterodimer)
4700:heterodimer)
4629:Antagonists:
4628:
4600:
4579:
4558:
4518:
4497:
4470:Risankizumab
4451:
4441:
4419:
4409:
4392:NNC0114-0006
4387:NNC0114-0005
4383:
4368:
4346:
4326:
4305:
4280:
4234:
4199:
4173:
4156:Tralokinumab
4151:Lebrikizumab
4146:Anrukinzumab
4142:
4117:
4091:
4076:
4050:
4024:
4003:
3993:
3952:
3909:
3895:Clazakizumab
3886:
3871:
3850:
3834:Benralizumab
3830:
3821:Antagonists:
3820:
3810:
3793:Pascolizumab
3784:
3775:Antagonists:
3774:
3754:
3708:
3677:
3632:
3611:
3591:
3567:Antagonists:
3566:
3537:
3365:Risankizumab
3354:
3350:Lebrikizumab
3330:Clazakizumab
3320:Anrukinzumab
3299:Tralokinumab
3215:Otelixizumab
3195:
3187:
3186:
3156:Tregalizumab
3141:Tislelizumab
3111:Satralizumab
3091:Rontalizumab
3086:Retifanlimab
3061:Plozalizumab
3041:Pateclizumab
3036:Pascolizumab
3031:Ozoralizumab
2981:Lampalizumab
2971:Inebilizumab
2961:Fontolizumab
2911:Camrelizumab
2906:Benralizumab
2901:Atezolizumab
2887:
2830:Clenoliximab
2731:
2715:Bertilimumab
2710:
2699:Tremelimumab
2679:
2602:Mavrilimumab
2592:Lirentelimab
2587:Lerdelimumab
2562:Fresolimumab
2502:Atorolimumab
2480:
2412:Upadacitinib
2372:Satralizumab
2357:Ritlecitinib
2352:Risankizumab
2316:
2147:
2128:
2068:Teprotumumab
2018:Inebilizumab
2013:Fontolizumab
1993:Atorolimumab
1961:T-lymphocyte
1959:
1933:
1917:
1903:
1884:
1873:Lerdelimumab
1868:Bertilimumab
1860:
1848:
1827:
1813:
1799:
1785:
1766:
1747:
1731:Pascolizumab
1716:Obinutuzumab
1708:
1694:
1680:
1664:Clenoliximab
1656:
1640:Otelixizumab
1627:
1600:
1587:Lebrikizumab
1571:
1555:
1539:
1523:
1507:
1464:Satralizumab
1454:Risankizumab
1443:
1386:
1345:
1329:
1321:Serum target
1273:Temsirolimus
1199:
1190:Pomalidomide
1185:Lenalidomide
1143:Pimecrolimus
1122:
1096:Methotrexate
1088:
1066:
1053:Azathioprine
1045:
1030:(initiation)
973:
970:"Olokizumab"
955:
921:
916:
902:
897:
872:
868:
862:
827:
823:
796:
791:
780:. Retrieved
776:
767:
745:(1): 61β82.
742:
738:
732:
697:
693:
683:
672:. Retrieved
670:(in Russian)
667:
628:
624:
614:
579:
575:
565:
552:
548:
536:
533:
530:
526:
517:
513:
498:
489:
474:Please help
462:
407:
398:
383:Please help
371:
344:
331:methotrexate
327:
319:Medical uses
296:
295:
284:
278:
156:1007223-17-7
129:Elimination
90:Subcutaneous
18:
4480:Ustekinumab
4460:Briakinumab
4452:Antibodies:
4423:Fezakinumab
4420:Antibodies:
4384:Antibodies:
4372:Denenicokin
4347:Antibodies:
4284:Iboctadekin
4263:Vunakizumab
4258:Secukinumab
4248:Perakizumab
4235:Antibodies:
4143:Antibodies:
4100:Ustekinumab
4095:Briakinumab
4092:Antibodies:
4004:Antibodies:
3930:Tocilizumab
3900:Elsilimomab
3887:Antibodies:
3839:Mepolizumab
3831:Antibodies:
3785:Antibodies:
3712:Daniplestim
3681:Basiliximab
3678:Antibodies:
3646:Celmoleukin
3641:Aldesleukin
3605:Lutikizumab
3600:Gevokizumab
3595:Canakinumab
3592:Antibodies:
3461:from market
3431:Lemalesomab
3426:Fanolesomab
3421:Besilesomab
3360:Perakizumab
3345:Mirikizumab
3335:Gevokizumab
3325:Bimekizumab
3304:Ustekinumab
3289:Secukinumab
3274:Fezakinumab
3269:Canakinumab
3264:Briakinumab
3239:Interleukin
3192:Dostarlimab
3171:Visilizumab
3166:Vedolizumab
3161:Vatelizumab
3151:Toralizumab
3146:Tocilizumab
3131:Teclistamab
3106:Samalizumab
3096:Rovelizumab
3076:Ravulizumab
3056:Pidilizumab
3051:Pexelizumab
3016:Ocrelizumab
3011:Natalizumab
3001:Mepolizumab
2991:Ligelizumab
2986:Letolizumab
2956:Etrolizumab
2946:Epratuzumab
2916:Cedelizumab
2870:Vapaliximab
2865:Teneliximab
2855:Lumiliximab
2840:Gomiliximab
2825:Basiliximab
2797:Vepalimomab
2782:Nerelimomab
2767:Gavilimomab
2762:Faralimomab
2757:Elsilimomab
2732:Combination
2725:Zanolimumab
2720:Ontamalimab
2668:Ulocuplumab
2663:Tezepelumab
2653:Sifalimumab
2633:Pamrevlumab
2612:Morolimumab
2607:Metelimumab
2577:Lanadelumab
2512:Avdoralimab
2497:Anifrolumab
2407:Tofacitinib
2347:Ravulizumab
2337:Pirfenidone
2327:Peficitinib
2227:Canakinumab
2217:Briakinumab
2207:Bimekizumab
2202:Baricitinib
2167:Aflibercept
2078:Vepalimomab
2073:Vapaliximab
2048:Rovelizumab
2038:Pexelizumab
2028:Morolimumab
2003:Cedelizumab
1988:Anifrolumab
1983:Alemtuzumab
1941:Basiliximab
1911:Tocilizumab
1897:Vedolizumab
1892:Natalizumab
1878:Metelimumab
1821:Gavilimomab
1779:Toralizumab
1774:Teneliximab
1760:Lumiliximab
1755:Gomiliximab
1741:Ublituximab
1721:Ocrelizumab
1674:Zanolimumab
1650:Visilizumab
1608:Secukinumab
1592:Ustekinumab
1563:Elsilimomab
1547:Faralimomab
1515:Mepolizumab
1499:Ustekinumab
1494:Tocilizumab
1469:Secukinumab
1419:Canakinumab
1409:Briakinumab
1404:Bimekizumab
1399:Basiliximab
1388:Interleukin
1378:Nerelimomab
1283:Zotarolimus
1224:(reception)
1195:Thalidomide
1153:Voclosporin
1138:Ciclosporin
1132:Calcineurin
1128:Cyclophilin
1075:Leflunomide
1071:inhibitors
956:Olokizumab
923:NCT03120949
904:NCT02760433
798:NCT02760368
538:NCT02760407
141:Identifiers
74:Trade names
4535:B (IFN-Ξ»3)
4531:A (IFN-Ξ»2)
4465:Guselkumab
4455:Brazikumab
4350:Fletikumab
4253:Remtolumab
4243:Ixekizumab
4238:Brodalumab
4121:Binetrakin
4059:Oprelvekin
4028:Ilodecakin
4007:Enokizumab
3920:Siltuximab
3910:Olokizumab
3844:Reslizumab
3778:Pitrakinra
3758:Binetrakin
3727:Milodistim
3722:Leridistim
3691:Inolimomab
3666:Teceleukin
3585:Isunakinra
3522:modulators
3391:Lokivetmab
3384:Veterinary
3370:Spesolimab
3355:Olokizumab
3340:Ixekizumab
3284:Guselkumab
3279:Fletikumab
3259:Brazikumab
3254:Bermekimab
3225:Sutimlimab
3199:Ibalizumab
3136:Teplizumab
3116:Siplizumab
3101:Ruplizumab
3081:Reslizumab
3071:Quilizumab
3026:Omalizumab
2976:Itolizumab
2966:Frexalimab
2941:Efalizumab
2936:Eculizumab
2931:Daclizumab
2896:Aselizumab
2891:Apolizumab
2860:Priliximab
2845:Infliximab
2787:Odulimomab
2777:Maslimomab
2772:Inolimomab
2752:Afelimomab
2689:Durvalumab
2684:Ipilimumab
2673:Varlilumab
2643:Relatlimab
2638:Placulumab
2582:Lenzilumab
2557:Emapalumab
2542:Cemiplimab
2527:Brodalumab
2522:Bleselumab
2492:Adalimumab
2397:Sutimlimab
2392:Spesolimab
2377:Siltuximab
2317:Olokizumab
2307:Ixekizumab
2302:Itacitinib
2292:Guselkumab
2287:Fingolimod
2282:Filgotinib
2232:Crovalimab
2222:Brodalumab
2212:Blisibimod
2177:Rilonacept
2160:Opinercept
2155:Etanercept
2141:Belatacept
2092:Polyclonal
2053:Siplizumab
2043:Reslizumab
2033:Ofatumumab
2023:Maslimomab
2008:Emapalumab
1951:Inolimomab
1946:Daclizumab
1925:Odulimomab
1840:Ruplizumab
1835:Frexalimab
1793:Aselizumab
1688:Efalizumab
1645:Teplizumab
1541:Interferon
1531:Omalizumab
1484:Spesolimab
1474:Siltuximab
1449:Rilonacept
1444:Olokizumab
1434:Ixekizumab
1429:Guselkumab
1424:Daclizumab
1414:Brodalumab
1373:Infliximab
1358:Afelimomab
1353:Adalimumab
1337:Eculizumab
1313:Monoclonal
1304:Antibodies
1278:Umirolimus
1258:Everolimus
1207:Apremilast
1167:Gusperimus
1148:Tacrolimus
1116:inhibitors
1108:Macrolides
1090:antifolate
958:(Q7088501)
782:2024-04-01
674:2024-04-01
557:References
492:April 2024
401:April 2024
268:Molar mass
212:PAI71R1D2W
187:ChemSpider
147:CAS Number
23:Olokizumab
4740:Unsorted:
4601:Agonists:
4580:Agonists:
4559:Agonists:
4519:Agonists:
4498:Agonists:
4442:Agonists:
4410:Agonists:
4369:Agonists:
4327:Agonists:
4299:Tadekinig
4281:Agonists:
4200:Agonists:
4174:Agonists:
4118:Agonists:
4077:Agonists:
4051:Agonists:
4025:Agonists:
3994:Agonists:
3953:Agonists:
3935:Levilimab
3925:Sirukumab
3915:Sarilumab
3872:Agonists:
3811:Agonists:
3788:Dupilumab
3755:Agonists:
3732:Muplestim
3709:Agonists:
3633:Agonists:
3560:Pifonakin
3555:Mobenakin
3538:Agonists:
3471:Phase III
3459:Withdrawn
3436:Sulesomab
3313:Humanized
3294:Sirukumab
3126:Talizumab
2951:Erlizumab
2880:Humanized
2850:Keliximab
2835:Galiximab
2694:Nivolumab
2658:Tabalumab
2648:Sarilumab
2622:Oleclumab
2617:Namilumab
2597:Lirilumab
2572:Ianalumab
2567:Golimumab
2552:Eldelumab
2547:Dupilumab
2517:Belimumab
2487:Abrilumab
2387:Sirukumab
2382:Siponimod
2367:Sarilumab
2342:Ponesimod
2312:Netakimab
2297:Iptacopan
2277:Etrasimod
2237:Danicopan
2172:Alefacept
2136:Abatacept
2058:Talizumab
1998:Begelomab
1854:Belimumab
1807:Galiximab
1736:Rituximab
1702:Erlizumab
1669:Keliximab
1479:Sirukumab
1459:Sarilumab
1439:Netakimab
1368:Golimumab
1268:Sirolimus
647:1995-4492
463:does not
372:does not
272:146000 Da
131:half-life
84:Routes of
51:Humanized
4789:Category
4779:Medicine
4694:IL-22RΞ±1
4660:instead.
3977:instead.
3905:mAb 1339
3890:ARGX-109
3854:TPI ASM8
3824:YM-90709
3575:Anakinra
3570:AF-12198
2812:Chimeric
2704:Urelumab
2627:Oxelumab
2537:Carlumab
2507:Avelumab
2456:for the
2322:Ozanimod
2197:Avacopan
2190:Unsorted
1976:Unsorted
1886:Integrin
1619:Cellular
1394:Anakinra
1240:Anakinra
1162:Abetimus
1014: /
889:36001712
854:36109142
759:36535857
724:36792848
715:10202974
606:36792848
597:10202974
341:COVID-19
305:COVID-19
287:(verify)
167:DrugBank
96:ATC code
78:Artlegia
4712:IL-10RΞ²
4708:IL-20RΞ±
4698:IL-20RΞ²
4632:IL-36RA
4177:ALT-803
3406:lesions
3181:TGN1412
3066:PRO 140
2118:-cept (
951:Scholia
845:9664111
523:History
484:removed
469:sources
393:removed
378:sources
176:DB13127
136:31 days
112:)
106: (
104:L04AC23
4765:Portal
4668:Others
4641:Others
4593:IL1RL2
4572:IL1RL1
4309:IL18BP
3580:IL-1RA
3454:WHO-EM
3196:Other:
2130:CTLA-4
2120:Fusion
1621:target
1602:IL-17A
1579:, and
1112:other
887:
852:
842:
757:
722:
712:
645:
604:
594:
243:ChEMBL
232:D12487
57:Target
47:Source
4551:IL-31
4511:IL-28
4490:IL-27
4434:IL-23
4402:IL-22
4361:IL-21
4319:IL-20
4273:IL-18
4192:IL-17
4166:IL-15
4110:IL-13
4069:IL-12
4043:IL-11
4017:IL-10
3414:Mouse
3247:Human
2745:Mouse
2711:Other
2474:Human
1919:LFA-1
1829:CD154
1682:CD11a
1581:IL-23
1577:IL-13
1573:IL-12
1177:IMiDs
4658:here
4656:See
3986:IL-9
3975:here
3966:IL-8
3945:IL-7
3864:IL-6
3803:IL-5
3747:IL-4
3701:IL-3
3625:IL-2
3530:IL-1
1849:BLyS
1801:CD80
1768:CD40
1749:CD23
1710:CD20
1696:CD18
1557:IL-6
1250:mTOR
1124:FKBP
1114:IL-2
885:PMID
850:PMID
755:PMID
720:PMID
643:ISSN
602:PMID
467:any
465:cite
376:any
374:cite
303:and
223:KEGG
203:UNII
194:none
123:data
37:Type
4684:CD4
4649:JAK
1862:CAT
1658:CD4
1629:CD3
1347:TNF
1020:L04
877:doi
873:387
840:PMC
832:doi
747:doi
710:PMC
702:doi
633:doi
592:PMC
584:doi
478:by
387:by
333:or
109:WHO
62:IL6
4791::
4614:,
4610:,
4533:,
4225:,
4221:,
4217:,
4213:,
4209:,
3547:,
3467::
3190::
2734::
2713::
2682::
2485::
1575:,
972:.
883:.
871:.
848:.
838:.
828:81
826:.
822:.
810:^
775:.
753:.
743:26
741:.
718:.
708:.
698:42
696:.
692:.
655:^
641:.
629:60
600:.
590:.
580:42
578:.
574:.
4767::
4729:)
4710:/
4696:/
4686:)
4618:)
4616:Ξ³
4612:Ξ²
4608:Ξ±
4606:(
4537:)
4529:(
4229:)
4227:F
4219:D
4215:C
4211:B
4207:A
4205:(
3551:)
3549:Ξ²
3545:Ξ±
3543:(
3511:e
3504:t
3497:v
3022:)
3018:(
2629:Β§
2446:e
2439:t
2432:v
2273:)
2269:(
2122:)
1968:)
1964:(
1727:)
1723:(
1130:/
1126:/
1110:/
1022:)
1018:(
1004:e
997:t
990:v
962:.
891:.
879::
856:.
834::
785:.
761:.
749::
726:.
704::
677:.
649:.
635::
608:.
586::
505:)
499:(
494:)
490:(
486:.
472:.
414:)
408:(
403:)
399:(
395:.
381:.
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