316:
59:
31:
408:
227:
can be classified into eight different genotypes from different geographical regions: genotype 1 (Asia), genotype 2 (Africa and Mexico), genotype 3 (Europe and North
America), genotype 4 (Asia); genotypes 5 and 6 have been detected in Asian wild boar and genotypes 7 and 8 in camels.
388:
The strains of HEV that exist today may have arisen from a shared ancestor virus 536 to 1344 years ago. Another analysis has dated the origin of
Hepatitis E to ~6000 years ago, with a suggestion that this was associated with domestication of pigs. At some point, two
215:
Globally, approximately 939 million corresponding to 1 in 8 individuals have ever experienced HEV infection. About 15–110 million individuals have recent or ongoing HEV infection. The virus particle was first seen in 1983, but was only molecularly cloned in 1989.
239:(ORF1, ORF2 and ORF3) encode for three proteins (O1, O2, O3), two of which are polyproteins, that is, they are cleaved into fragments which carry out the actual functions of the virus (see figure). The
396:
Whereas genotype 2 remains less commonly detected than other genotypes, genetic evolutionary analyses suggest that genotypes 1, 3, and 4 have spread substantially during the past 100 years.
1634:
334:
proteins has been mapped by
Osterman et al. (2015), who found 25 interactions among the 10 proteins studied. Almost all (24) of these interactions were considered as of "high quality".
315:
1057:
984:
2141:
2154:
1648:
949:
Mirazo S, Mir D, Bello G, Ramos N, Musto H, Arbiza J (2016). "New insights into the hepatitis E virus genotype 3 phylodynamics and evolutionary history".
1314:
393:
may have diverged — an anthropotropic form and an enzootic form — which subsequently evolved into genotypes 1 and 2 and genotypes 3 and 4, respectively.
1145:
630:
Balayan MS, Andjaparidze AG, Savinskaya SS, et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route".
1185:
665:
Reyes GR, Purdy MA, Kim JP, et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis".
1050:
1278:
1335:
1654:
1180:
1137:
1569:
1640:
1043:
38:
1239:
1225:
1029:"Virus Pathogen Database and Analysis Resource (ViPR) – Hepeviridae – Genome database with visualization and analysis tools"
58:
1444:
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1349:
1343:
1233:
284:
1807:
1733:
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1400:
2159:
1864:
1471:
766:
Osterman A, Stellberger T, Gebhardt A, Kurz M, Friedel CC, Uetz P, Nitschko H, Baiker A, Vizoso-Pinto MG (2015).
707:
Schlauder, G. G. & Mushahwar, I. K. (2001) Genetic heterogeneity of hepatitis E virus. J Med Virol 65, 282–92
997:
Izopet J, Abravanel F, Dalton H, Nassim RK (2014) Hepatitis E Virus
Infection. Clin Micro Reviews 27 (1) 116–138
2187:
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Baha, Sarra; Behloul, Nouredine; Liu, Zhenzhen; Wei, Wenjuan; Shi, Ruihua; Meng, Jihong (2019-10-29).
2182:
2012:
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1308:
836:
779:
674:
260:
53:
1430:
1151:
1533:
1289:
576:
Li P, Liu J, Li Y, Su J, Ma Z, Bramer WM, Cao W, de Man RA, Peppelenbosch MP, Pan Q (July 2020).
236:
178:
1035:
2146:
578:"The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis"
2100:
1997:
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protein encodes the capsid, which is composed of three domains, namely the shell domain (
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892:"Comprehensive analysis of genetic and evolutionary features of the hepatitis E virus"
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domain is a fusion protein consisting of the Plp, V, and X domains. The
276:
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407:
1383:
390:
361:
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825:"Evolutionary History and Population Dynamics of Hepatitis E Virus"
2034:
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70:
311:). Numbers in the figure indicate positions in the RNA sequence.
2051:
1039:
559:"Hepeviridae - Hepeviridae - Positive-sense RNA Viruses - ICTV"
1260:
295:
protein is encoded by a single open-reading frame (ORF3). The
232:
823:
Khudyakov, Yury E.; Purdy, Michael A. (17 December 2010).
1011:"Hepeviridae – Hepeviridae – Positive-sense RNA Viruses"
231:
The viral genome is a single strand of positive-sense
512:
International
Committee on Taxonomy of Viruses (ICTV)
2116:
2060:
2011:
1987:
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243:protein consists of seven such fragments, namely
368:. It is now classified as a member of the genus
768:"The Hepatitis E virus intraviral interactome"
494:
492:
490:
235:that is about 7200 bases in length. The three
1051:
8:
983:: CS1 maint: multiple names: authors list (
553:
551:
549:
547:
499:Purdy, Michael A.; et al. (June 2014).
354:It was previously classified in the family
2048:
1770:
1550:
1315:Progressive multifocal leukoencephalopathy
1285:
1058:
1044:
1036:
29:
18:
1186:Extranodal NK/T-cell lymphoma, nasal type
1020:at the U.S. National Library of Medicine
925:
907:
866:
848:
799:
742:
719:"Molecular virology of hepatitis E virus"
603:
593:
486:
463:
976:
7:
717:Ahmad I, Holla RP, Jameel S (2011).
625:
623:
1336:Subacute sclerosing panencephalitis
346:in diameter and are not enveloped.
14:
1655:Severe acute respiratory syndrome
1181:Follicular dendritic cell sarcoma
342:The viral particles are 27 to 34
1641:Middle East respiratory syndrome
406:
314:
267:(proline-rich variable region),
57:
501:"New Classification Scheme for
1240:Adult T-cell leukemia/lymphoma
1226:Splenic marginal zone lymphoma
735:10.1016/j.virusres.2011.02.011
303:) and two protruding domains (
1:
1445:Tropical spastic paraparesis
1350:Lymphocytic choriomeningitis
963:10.1016/j.meegid.2016.06.003
850:10.1371/journal.pone.0014376
470:The former species name was
285:RNA-dependent RNA polymerase
205:) is the causative agent of
1808:Cytomegalovirus esophagitis
1728:Human parainfluenza viruses
1401:Ramsay Hunt syndrome type 2
2204:
271:(X-domain, macro-domain),
1472:Cytomegalovirus retinitis
909:10.1186/s12864-019-6100-8
184:
177:
52:
37:
28:
21:
1574:Infectious mononucleosis
1391:Chandipura vesiculovirus
1221:Hepatocellular carcinoma
1166:Nasopharyngeal carcinoma
1099:Hepatocellular carcinoma
1022:Medical Subject Headings
1370:Encephalitis lethargica
1071:viral systemic diseases
687:10.1126/science.2107574
533:Avian hepatitis E virus
364:more closely resembles
209:. It is of the species
1742:Human orthopneumovirus
1396:Herpesviral meningitis
1357:Arbovirus encephalitis
1200:Merkel-cell carcinoma
1845:Adenovirus infection
1309:Human polyomavirus 2
1138:Oropharyngeal cancer
326:The protein-protein
261:papain-like protease
54:Virus classification
1431:Post-polio syndrome
1067:Infectious diseases
841:2010PLoSO...514376P
784:2015NatSR...513872O
679:1990Sci...247.1335R
582:Liver International
237:open reading frames
220:Genome and proteome
1564:Epstein–Barr virus
1534:Respiratory system
1171:Burkitt's lymphoma
531:, and the species
2170:
2169:
2118:Hepatitis E virus
2054:Taxon identifiers
2045:
2044:
2007:
2006:
1758:
1757:
1689:Influenza virus A
1606:Human coronavirus
1496:
1495:
1486:Herpes of the eye
1018:Hepatitis+E+virus
951:Infect Genet Evol
792:10.1038/srep13872
644:10.1159/000149370
595:10.1111/liv.14468
525:Hepatitis E virus
472:Hepatitis E virus
441:Hepatitis C virus
431:Hepatitis B virus
249:methyltransferase
211:Orthohepevirus A.
199:hepatitis E virus
195:
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188:Hepatitis E virus
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2092:Orthohepevirus A
2081:
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2062:Orthohepevirus A
2049:
1771:
1766:digestive system
1683:Orthomyxoviridae
1649:SARS coronavirus
1635:MERS coronavirus
1551:
1363:Orthomyxoviridae
1286:
1252:Immune disorders
1176:Hodgkin lymphoma
1152:Kaposi's sarcoma
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673:(4948): 1335–9.
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588:(7): 1516–1528.
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537:Orthohepevirus B
535:will be renamed
529:Orthohepevirus A
527:will be renamed
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332:Orthohepevirus A
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225:Orthohepevirus A
170:Orthohepevirus A
62:
61:
46:Orthohepevirus A
33:
23:Orthohepevirus A
19:
16:Species of virus
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1865:Gastroenteritis
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1820:Gastroenteritis
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1802:Cytomegalovirus
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1722:Paramyxoviridae
1711:Avian influenza
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1582:Cytomegalovirus
1546:viral pneumonia
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1541:nasopharyngitis
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1466:Cytomegalovirus
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1886:Coronavirus
1627:Common cold
1539:acute viral
1522:Myocarditis
1366:(probable)
1118:Anal cancer
503:Hepeviridae
452:Hepatitis E
447:Hepatitis D
437:Hepatitis C
427:Hepatitis B
422:Hepatitis A
377:Hepeviridae
328:interactome
322:Interactome
207:hepatitis E
145:Hepeviridae
2177:Categories
2013:Urogenital
1879:Astrovirus
1839:Adenovirus
1663:SARS-CoV-2
1420:Poliovirus
1295:meningitis
957:: 267–73.
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482:References
344:nanometers
42:micrograph
2077:Q24757533
1924:RNA virus
1905:DNA virus
1897:Hepatitis
1872:Norovirus
1860:Rotavirus
1854:RNA virus
1833:DNA virus
1779:Esophagus
1707:Influenza
1593:RNA virus
1555:DNA virus
1324:RNA virus
1303:DNA virus
1209:RNA virus
1087:DNA virus
1079:Oncovirus
918:1471-2164
859:1932-6203
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723:Virus Res
384:Evolution
338:Structure
164:Species:
92:Kingdom:
85:Riboviria
2147:11459945
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2127:Wikidata
2071:Wikidata
2022:BK virus
1825:diarrhea
1669:COVID-19
1411:Myelitis
971:27264728
936:31664890
877:21203540
829:PLOS ONE
810:26463011
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614:32281721
400:See also
350:Taxonomy
277:helicase
179:Synonyms
140:Family:
104:Phylum:
48:virions
1775:Pharynx
1279:Central
927:6820953
868:3006657
837:Bibcode
801:4604457
780:Bibcode
772:Sci Rep
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667:Science
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1794:Mumps
1764:Human
1194:MCPyV
517:1 May
508:(PDF)
458:Notes
78:Realm
71:Virus
2155:NCBI
1749:hMPV
1621:OC43
1617:HKU1
1613:NL63
1609:229E
1267:AIDS
1146:KSHV
985:link
967:PMID
932:PMID
914:ISSN
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691:PMID
648:PMID
610:PMID
519:2019
281:Rdrp
197:The
2101:CoL
2029:MuV
1998:CBV
1973:HEV
1961:HDV
1949:HCV
1937:HAV
1930:CBV
1911:HBV
1788:MuV
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1480:HSV
1457:Eye
1344:LCV
1330:MeV
1261:HIV
1215:HCV
1160:EBV
1107:HPV
1093:HBV
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
