325:
302:
1437:
has been localized in a variety of tissues, but is found in greatest abundance in osseous tissue, tissues characterized by high turnover (such as intestinal epithelium), basement membranes, and certain neoplasms. Osteonectin is expressed by a wide variety of cells, including chondrocytes, fibroblasts, platelets, endothelial cells, epithelial cells, Leydig cells, Sertoli cells, luteal cells, adrenal cortical cells, and numerous neoplastic cell lines (such as SaOS-2 cells from human osteosarcoma).
199:
224:
2921:
576:
583:
331:
230:
2906:
40:
2891:
1432:
Fibroblasts, including periodontal fibroblasts, synthesize osteonectin. This protein is synthesized by macrophages at sites of wound repair and platelet degranulation, so it may play an important role in wound healing. SPARC does not support cell attachment, and like tenascin, is anti-adhesive and an
1436:
High levels of immunodetectable osteonectin are found in active osteoblasts and marrow progenitor cells, odontoblasts, periodontal ligament and gingival cells, and some chondrocytes and hypertrophic chondrocytes. Osteonectin is also detectable in osteoid, bone matrix proper, and dentin. Osteonectin
1433:
inhibitor of cell spreading. It disrupts focal adhesions in fibroblasts. It also regulates the proliferation of some cells, especially endothelial cells, mediated by its ability to bind to cytokines and growth factors. Osteonectin has also been found to decrease DNA synthesis in cultured bone.
1415:
This molecule has been implicated in several biological functions, including mineralization of bone and cartilage, inhibiting mineralization, modulation of cell proliferation, facilitation of acquisition of differentiated phenotype and promotion of cell attachment and spreading.
66:
1419:
A number of phosphoproteins and glycoproteins are found in bone. The phosphate is bound to the protein backbone through phosphorylated serine or threonine amino acid residues. The best characterized of these bone proteins is osteonectin. It binds collagen and
2420:
Maurer P, Hohenadl C, Hohenester E, Göhring W, Timpl R, Engel J (Oct 1995). "The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV".
3379:
1615:
Wasi S, Otsuka K, Yao KL, Tung PS, Aubin JE, Sodek J, Termine JD (Jun 1984). "An osteonectinlike protein in porcine periodontal ligament and its synthesis by periodontal ligament fibroblasts".
2046:
Swaroop A, Hogan BL, Francke U (Jan 1988). "Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33".
2920:
2280:"Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone"
2387:"Role of N-linked glycosylation in human osteonectin. Effect of carbohydrate removal by N-glycanase and site-directed mutagenesis on structure and binding of type V collagen"
1773:
Altura BM (Jun 1975). "Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial, and terminal vascular smooth".
338:
237:
2721:
1966:
Metsäranta M, Young MF, Sandberg M, Termine J, Vuorio E (Sep 1989). "Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization".
2005:"SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix"
3364:
1650:
Young MF, Kerr JM, Ibaraki K, Heegaard AM, Robey PG (Aug 1992). "Structure, expression, and regulation of the major noncollagenous matrix proteins of bone".
2961:
1812:"The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors"
996:
160:
977:
2489:
2348:
Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (Oct 1981). "Osteonectin, a bone-specific protein linking mineral to collagen".
2660:
4081:
4636:
3459:
2635:
2870:
1513:
1495:
4626:
3179:
2905:
324:
63:
4458:
1220:
2756:
1227:
301:
4498:
1400:, a function important to invading cancer cells within bone. Additional functions of osteonectin beneficial to tumor cells include
4348:
2837:
1531:
Villarreal XC, Mann KG, Long GL (Jul 1989). "Structure of human osteonectin based upon analysis of cDNA and genomic sequences".
4641:
3397:
3387:
2954:
1482:
1461:
1364:-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca binding domain near the
1316:
during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for
4646:
1478:
223:
198:
3147:
3118:
2482:
2077:"Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane"
1457:
140:
4595:
4074:
3729:
3538:
1424:
in separate domains, is found in relatively large amounts in immature bone, and promotes mineralization of collagen.
337:
236:
2147:"Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)"
4585:
3975:
2947:
1412:. Overexpression of osteonectin is reported in many human cancers such as breast, prostate, colon and pancreatic.
330:
229:
4548:
4508:
2890:
2863:
2604:
2241:
Jundt G, Berghäuser KH, Termine JD, Schulz A (May 1987). "Osteonectin--a differentiation marker of bone cells".
4488:
4463:
3437:
3244:
3214:
3108:
2475:
2461:
1397:
1041:
148:
3523:
1022:
4059:
2939:
4631:
4523:
4067:
3172:
3167:
3162:
3157:
3152:
2498:
2696:
2315:"Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture"
3359:
1566:
Guweidhi A, Kleeff J, Adwan H, Giese NA, Wente MN, Giese T, Büchler MW, Berger MR, Friess H (Aug 2005).
3904:
2856:
2716:
2201:
1823:
1389:
1325:
212:
127:
4528:
4453:
4340:
4317:
4281:
4253:
3870:
3687:
3342:
1199:
1174:
1170:
1144:
1119:
1115:
4478:
3950:
3392:
3322:
3312:
3184:
3140:
2995:
2978:
2791:
2678:
2373:
2266:
2176:
1991:
1798:
1716:
172:
3297:
1203:
1178:
1140:
1111:
2929:: STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN
2786:
2524:
4553:
4382:
3965:
3369:
3351:
2974:
2761:
2594:
2438:
2408:
2365:
2336:
2301:
2258:
2229:
2168:
2133:
2098:
2063:
2034:
1983:
1954:
1921:
1886:
1851:
1790:
1761:
1708:
1667:
1632:
1597:
1548:
1396:
interactions, and collagen binding. Osteonectin also increases the production and activity of
575:
120:
56:
4468:
4285:
4238:
3960:
3778:
3128:
2736:
2630:
2619:
2549:
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2357:
2326:
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2250:
2219:
2209:
2158:
2123:
2088:
2055:
2024:
2016:
1975:
1946:
1911:
1876:
1841:
1831:
1782:
1751:
1698:
1659:
1624:
1587:
1579:
1540:
1377:
1372:(domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an
1321:
1320:
in addition to bone mineral calcium. A correlation between osteonectin over-expression and
417:
348:
292:
247:
3832:
3073:
2726:
1865:"Distribution of osteonectin mRNA and protein during human embryonic and fetal development"
582:
168:
4425:
4397:
4313:
4043:
3206:
3100:
3038:
2544:
2110:
Clezardin P, Malaval L, Ehrensperger AS, Delmas PD, Dechavanne M, McGregor JL (Aug 1988).
392:
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1827:
4575:
4094:
4015:
3113:
2970:
2806:
2801:
2741:
2683:
2613:
2569:
2564:
2457:
2128:
2111:
2093:
2076:
2029:
2004:
1900:"Human platelet osteonectin: release, surface expression, and partial characterization"
1592:
1583:
1567:
1421:
1409:
1369:
39:
2331:
2314:
2296:
2279:
2224:
2190:"Human platelets contain and secrete osteonectin, a major protein of mineralized bone"
2189:
911:
906:
901:
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891:
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3133:
3123:
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2559:
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2163:
2146:
2059:
1846:
1811:
1663:
1393:
1365:
611:
2270:
2180:
1995:
1802:
1720:
4493:
4405:
4272:
4102:
4098:
3945:
3695:
3654:
3587:
2832:
2746:
2529:
2377:
1401:
1305:
410:
189:
1916:
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152:
176:
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4563:
4518:
4387:
4243:
4233:
4110:
4000:
3980:
3577:
3560:
3555:
3327:
3317:
3018:
3008:
2796:
2781:
2711:
2706:
2609:
2589:
2519:
1518:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1500:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1405:
24:
20:
2194:
Proceedings of the
National Academy of Sciences of the United States of America
1816:
Proceedings of the
National Academy of Sciences of the United States of America
1756:
1739:
1703:
1686:
493:
4433:
4048:
3865:
3664:
3528:
3513:
3476:
3307:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
2731:
2640:
2534:
1950:
1313:
309:
206:
156:
2403:
2386:
4543:
4538:
4513:
4503:
4415:
4023:
3895:
3880:
3875:
3565:
3533:
3471:
2766:
2599:
2214:
1786:
941:
553:
431:
376:
363:
275:
262:
164:
2434:
1933:
Young MF, Day AA, Dominquez P, McQuillan CI, Fisher LW, Termine JD (1990).
1836:
1765:
1601:
2442:
2412:
2369:
2340:
2305:
2262:
2233:
2172:
2137:
2102:
2067:
2038:
2020:
1987:
1958:
1925:
1890:
1855:
1794:
1712:
1671:
1636:
1552:
1267:
1262:
4362:
4357:
4352:
4330:
4325:
4303:
4298:
4258:
4028:
3789:
3700:
3518:
3463:
3003:
2751:
2506:
1881:
1864:
1740:"SPARC, a matricellular glycoprotein with important biological functions"
1687:"The biology of SPARC, a protein that modulates cell-matrix interactions"
1361:
1337:
1317:
1251:
1086:
1067:
1544:
4410:
4293:
4090:
4038:
3992:
3913:
3797:
3710:
3447:
3302:
3254:
2811:
2776:
2701:
2670:
2650:
2254:
2145:
Lankat-Buttgereit B, Mann K, Deutzmann R, Timpl R, Krieg T (Aug 1988).
1979:
1568:"Osteonectin influences growth and invasion of pancreatic cancer cells"
1373:
1291:
1053:
1008:
97:
93:
89:
85:
4483:
4202:
4162:
3847:
3817:
3759:
3754:
3749:
3744:
3739:
3721:
3548:
3543:
3501:
3496:
3442:
3430:
3425:
3420:
3224:
3219:
2771:
2584:
2579:
2574:
2554:
2514:
2075:
Wewer UM, Albrechtsen R, Fisher LW, Young MF, Termine JD (Aug 1988).
1345:
1235:
963:
1934:
1628:
4377:
4372:
4217:
4212:
4207:
4197:
4192:
4187:
4167:
4152:
4147:
4132:
4119:
3938:
3933:
3928:
3923:
3918:
3842:
3837:
3827:
3822:
3812:
3807:
3802:
3771:
3766:
3734:
3705:
3674:
3669:
3659:
3647:
3642:
3637:
3570:
3491:
3486:
3481:
3415:
3088:
3083:
3078:
3068:
3063:
3058:
3053:
2816:
2655:
2467:
1810:
Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH (Feb 1992).
926:
922:
131:, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
4558:
4473:
4367:
4182:
4177:
4172:
4157:
4142:
4137:
4127:
3970:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3236:
3194:
3189:
3048:
3043:
3033:
3028:
3023:
3013:
2645:
1341:
1309:
1298:
144:
4063:
2943:
2852:
2471:
591:
2848:
2003:
Sage H, Vernon RB, Funk SE, Everitt EA, Angello J (Jul 1989).
1935:"Structure and expression of osteonectin mRNA in human tissue"
1357:
1392:
glycoprotein that plays a vital role in bone mineralization,
2112:"Complex formation of human thrombospondin with osteonectin"
2278:
Fisher LW, Hawkins GR, Tuross N, Termine JD (Jul 1987).
400:
1863:
Mundlos S, Schwahn B, Reichert T, Zabel B (Feb 1992).
832:
negative regulation of endothelial cell proliferation
565:
2914:: HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR
2188:
Stenner DD, Tracy RP, Riggs BL, Mann KG (Sep 1986).
4446:
4424:
4396:
4339:
4312:
4280:
4271:
4226:
4118:
4109:
4013:
3991:
3903:
3893:
3858:
3787:
3719:
3685:
3458:
3408:
3378:
3350:
3340:
3253:
3235:
3205:
3099:
2994:
2985:
2825:
2669:
2505:
1192:
1163:
1133:
1104:
1474:
1472:
1470:
1453:
1451:
1449:
1617:Canadian Journal of Biochemistry and Cell Biology
837:positive regulation of endothelial cell migration
347:
246:
2722:Cartilage-Derived Angiogenesis Inhibitory Factor
1869:The Journal of Histochemistry and Cytochemistry
1744:The Journal of Histochemistry and Cytochemistry
1479:GRCm38: Ensembl release 89: ENSMUSG00000018593
4075:
2955:
2864:
2483:
8:
1284:secreted protein acidic and rich in cysteine
2313:Sage H, Johnson C, Bornstein P (Mar 1984).
1458:GRCh38: Ensembl release 89: ENSG00000113140
867:regulation of cell population proliferation
792:cellular response to growth factor stimulus
650:extracellular matrix structural constituent
4277:
4115:
4082:
4068:
4060:
3900:
3347:
2991:
2962:
2948:
2940:
2871:
2857:
2849:
2490:
2476:
2468:
1652:Clinical Orthopaedics and Related Research
937:
607:
388:
287:
184:
74:
2460:at the U.S. National Library of Medicine
2402:
2330:
2295:
2223:
2213:
2162:
2127:
2092:
2028:
1915:
1880:
1845:
1835:
1755:
1702:
1591:
751:collagen-containing extracellular matrix
4388:Structural maintenance of chromosomes 3
2886:
1445:
1348:and is located on chromosome 5q31-q33.
16:Mammalian protein found in Homo sapiens
1312:that binds calcium. It is secreted by
29:
352:
313:
308:
251:
210:
205:
7:
2757:matrix metalloproteinase inhibitors
2391:The Journal of Biological Chemistry
2319:The Journal of Biological Chemistry
2284:The Journal of Biological Chemistry
872:negative regulation of angiogenesis
2129:10.1111/j.1432-1033.1988.tb14194.x
1584:10.1097/01.sla.0000171866.45848.68
1189:
1160:
1130:
1101:
1077:
1058:
1032:
1013:
987:
968:
912:regulation of synapse organization
691:intracellular anatomical structure
570:
488:
426:
405:
14:
4499:Cholesterylester transfer protein
4349:Chondroitin sulfate proteoglycans
2081:The American Journal of Pathology
1294:that in humans is encoded by the
807:extracellular matrix organization
2919:
2904:
2889:
2116:European Journal of Biochemistry
1664:10.1097/00003086-199208000-00042
882:regulation of cell morphogenesis
581:
574:
336:
329:
323:
300:
235:
228:
222:
197:
38:
3398:Calcium-induced calcium release
706:platelet alpha granule membrane
3119:Ionotropic glutamate receptors
1968:Calcified Tissue International
857:response to lipopolysaccharide
592:More reference expression data
554:More reference expression data
1:
4637:Extracellular matrix proteins
2332:10.1016/S0021-9258(17)43194-2
2297:10.1016/S0021-9258(18)47991-4
1917:10.1182/blood.V75.5.1105.1105
1898:Kelm RJ, Mann KG (Mar 1990).
1685:Lane TF, Sage EH (Feb 1994).
1336:The human SPARC gene is 26.5
827:receptor-mediated endocytosis
321:
220:
3971:Dentin matrix phosphoprotein
2423:Journal of Molecular Biology
2385:Xie RL, Long GL (Sep 1995).
2362:10.1016/0092-8674(81)90037-4
2164:10.1016/0014-5793(88)80054-1
2060:10.1016/0888-7543(88)90107-3
1288:basement-membrane protein 40
716:platelet alpha granule lumen
640:extracellular matrix binding
4627:Genes on human chromosome 5
4596:Tumor necrosis factor alpha
2009:The Journal of Cell Biology
1738:Yan Q, Sage EH (Dec 1999).
812:response to L-ascorbic acid
797:response to peptide hormone
446:stromal cell of endometrium
4663:
4586:Thyroxine-binding proteins
3976:Dentin sialophosphoprotein
2899:: BM-40, FS/EC DOMAIN PAIR
2605:proliferin-related protein
1939:Connective Tissue Research
1757:10.1177/002215549904701201
1704:10.1096/fasebj.8.2.8119487
817:response to glucocorticoid
18:
4549:Serum amyloid P component
4509:Colony-stimulating factor
3438:Sodium-calcium exchangers
3215:Sodium-calcium exchangers
2884:
1951:10.3109/03008209009152419
1514:"Mouse PubMed Reference:"
1496:"Human PubMed Reference:"
1398:matrix metalloproteinases
1388:Osteonectin is an acidic
1266:
1261:
1257:
1250:
1234:
1221:Chr 5: 151.66 – 151.69 Mb
1215:
1196:
1167:
1156:
1137:
1108:
1097:
1084:
1080:
1065:
1061:
1052:
1039:
1035:
1020:
1016:
1007:
994:
990:
975:
971:
962:
947:
940:
936:
920:
610:
606:
589:
573:
564:
551:
500:
491:
474:Descending thoracic aorta
438:
429:
399:
391:
387:
370:
357:
320:
299:
290:
286:
269:
256:
219:
196:
187:
183:
138:
135:
125:
118:
113:
82:
77:
60:
55:
50:
46:
37:
32:
4489:B-cell activating factor
4464:Alpha 1-antichymotrypsin
3524:Neuronal calcium sensors
3245:Calcium-sensing receptor
2462:Medical Subject Headings
2404:10.1074/jbc.270.39.23212
2243:Cell and Tissue Research
1228:Chr 11: 55.29 – 55.31 Mb
354:11 B1.3|11 33.04 cM
19:Not to be confused with
2838:Angiogenesis inhibitors
2215:10.1073/pnas.83.18.6892
1787:10.1161/01.res.36.6.233
842:response to calcium ion
777:response to cadmium ion
676:endocytic vesicle lumen
4642:Matricellular proteins
4524:Membrane glycoproteins
3380:Intracellular channels
2435:10.1006/jmbi.1995.0557
1837:10.1073/pnas.89.4.1281
1340:long, and contains 10
802:platelet degranulation
671:platelet alpha granule
4647:Genes mutated in mice
2021:10.1083/jcb.109.1.341
1781:(6 Suppl 1): 233–40.
877:inner ear development
756:glutamatergic synapse
528:stroma of bone marrow
315:Chromosome 11 (mouse)
3905:Extracellular matrix
2717:carboxyamidotriazole
2697:angiostatic steroids
1882:10.1177/40.2.1552170
1775:Circulation Research
1390:extracellular matrix
1380:region (domain IV).
1368:-rich region at the
1356:Osteonectin is a 40
1326:chronic pancreatitis
862:response to lead ion
772:response to cytokine
741:extracellular matrix
736:extracellular region
478:smooth muscle tissue
213:Chromosome 5 (human)
78:List of PDB id codes
51:Available structures
4529:Myelin protein zero
4454:Activin and inhibin
4254:Phytohaemagglutinin
3871:Parathyroid hormone
3859:Indirect regulators
3409:Intracellular pumps
2206:1986PNAS...83.6892S
1828:1992PNAS...89.1281R
1545:10.1021/bi00441a049
1428:Tissue distribution
1282:(ON) also known as
902:signal transduction
892:response to ethanol
847:response to gravity
726:extracellular space
625:calcium ion binding
458:trigeminal ganglion
4479:Asialoglycoprotein
3951:Matrix gla protein
3788:Calcium-dependent
3720:Calcium-dependent
3686:Calcium-dependent
3393:Ryanodine receptor
2996:Adhesion molecules
2979:calcium metabolism
2792:tetrathiomolybdate
2679:2-Methoxyestradiol
2356:(1 Pt 1): 99–105.
2255:10.1007/bf00218209
1980:10.1007/BF02556057
1042:ENSMUSG00000018593
765:Biological process
659:Cellular component
618:Molecular function
520:tibiofemoral joint
4614:
4613:
4554:Sialoglycoprotein
4442:
4441:
4383:Platelet factor 4
4267:
4266:
4057:
4056:
4009:
4008:
3993:Secreted hormones
3966:Bone sialoprotein
3889:
3888:
3352:Second messengers
3336:
3335:
3129:Kainate receptors
2975:calcium signaling
2937:
2936:
2846:
2845:
2817:VEGFR antagonists
2762:platelet factor-4
2595:platelet factor-4
1572:Annals of Surgery
1322:ampullary cancers
1304:Osteonectin is a
1277:
1276:
1273:
1272:
1246:
1245:
1211:
1210:
1186:
1185:
1152:
1151:
1127:
1126:
1093:
1092:
1074:
1073:
1048:
1047:
1029:
1028:
1003:
1002:
984:
983:
932:
931:
852:heart development
696:basement membrane
630:metal ion binding
602:
601:
598:
597:
560:
559:
547:
546:
485:
484:
450:periodontal fiber
383:
382:
282:
281:
177:SPARC - orthologs
109:
108:
105:
104:
61:Ortholog search:
4654:
4469:Apolipoprotein H
4278:
4239:Intrinsic factor
4116:
4084:
4077:
4070:
4061:
4014:Calcium-binding
3901:
3779:Protein kinase C
3348:
3101:Calcium channels
2992:
2964:
2957:
2950:
2941:
2923:
2908:
2893:
2873:
2866:
2859:
2850:
2631:Thrombospondin 1
2620:antithrombin III
2492:
2485:
2478:
2469:
2446:
2416:
2406:
2381:
2344:
2334:
2325:(6): 3993–4007.
2309:
2299:
2274:
2237:
2227:
2217:
2184:
2166:
2141:
2131:
2106:
2096:
2071:
2042:
2032:
1999:
1962:
1929:
1919:
1894:
1884:
1859:
1849:
1839:
1806:
1769:
1759:
1750:(12): 1495–506.
1725:
1724:
1706:
1682:
1676:
1675:
1647:
1641:
1640:
1612:
1606:
1605:
1595:
1563:
1557:
1556:
1528:
1522:
1521:
1510:
1504:
1503:
1492:
1486:
1476:
1465:
1455:
1378:carboxy terminus
1328:has been found.
1259:
1258:
1230:
1223:
1206:
1190:
1181:
1161:
1157:RefSeq (protein)
1147:
1131:
1122:
1102:
1078:
1059:
1033:
1014:
988:
969:
938:
897:bone development
887:response to cAMP
787:lung development
645:collagen binding
608:
594:
585:
578:
571:
556:
532:efferent ductule
496:
494:Top expressed in
489:
434:
432:Top expressed in
427:
406:
389:
379:
366:
355:
340:
333:
327:
316:
304:
288:
278:
265:
254:
239:
232:
226:
215:
201:
185:
179:
130:
123:
100:
75:
69:
48:
47:
42:
30:
4662:
4661:
4657:
4656:
4655:
4653:
4652:
4651:
4617:
4616:
4615:
4610:
4438:
4420:
4392:
4335:
4308:
4263:
4222:
4105:
4088:
4058:
4053:
4044:EGF-like domain
4005:
3987:
3885:
3854:
3783:
3715:
3681:
3454:
3404:
3374:
3332:
3249:
3231:
3201:
3095:
2981:
2968:
2938:
2933:
2930:
2924:
2915:
2909:
2900:
2894:
2880:
2877:
2847:
2842:
2821:
2691:
2687:
2665:
2651:soluble VEGFR-1
2501:
2499:Antiangiogenics
2496:
2454:
2449:
2419:
2397:(39): 23212–7.
2384:
2347:
2312:
2277:
2240:
2187:
2144:
2109:
2074:
2045:
2002:
1965:
1932:
1897:
1862:
1809:
1772:
1737:
1733:
1731:Further reading
1728:
1684:
1683:
1679:
1658:(281): 275–94.
1649:
1648:
1644:
1629:10.1139/o84-064
1614:
1613:
1609:
1565:
1564:
1560:
1539:(15): 6483–91.
1530:
1529:
1525:
1512:
1511:
1507:
1494:
1493:
1489:
1477:
1468:
1456:
1447:
1443:
1430:
1386:
1354:
1334:
1268:View/Edit Mouse
1263:View/Edit Human
1226:
1219:
1216:Location (UCSC)
1202:
1198:
1177:
1173:
1169:
1143:
1139:
1118:
1114:
1110:
1023:ENSG00000113140
916:
760:
686:plasma membrane
654:
635:protein binding
590:
580:
579:
552:
543:
538:
534:
530:
526:
522:
518:
514:
512:ascending aorta
510:
506:
492:
481:
476:
472:
470:visceral pleura
468:
464:
460:
456:
452:
448:
444:
430:
374:
361:
353:
343:
342:
341:
334:
314:
291:Gene location (
273:
260:
252:
242:
241:
240:
233:
211:
188:Gene location (
139:
126:
119:
84:
62:
28:
17:
12:
11:
5:
4660:
4658:
4650:
4649:
4644:
4639:
4634:
4629:
4619:
4618:
4612:
4611:
4609:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4576:Thrombopoietin
4573:
4572:
4571:
4566:
4561:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4471:
4466:
4461:
4456:
4450:
4448:
4444:
4443:
4440:
4439:
4437:
4436:
4430:
4428:
4422:
4421:
4419:
4418:
4413:
4408:
4402:
4400:
4394:
4393:
4391:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4345:
4343:
4337:
4336:
4334:
4333:
4328:
4322:
4320:
4310:
4309:
4307:
4306:
4301:
4296:
4290:
4288:
4275:
4269:
4268:
4265:
4264:
4262:
4261:
4256:
4251:
4246:
4241:
4236:
4230:
4228:
4224:
4223:
4221:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4124:
4122:
4113:
4107:
4106:
4095:glycoconjugate
4089:
4087:
4086:
4079:
4072:
4064:
4055:
4054:
4052:
4051:
4046:
4041:
4036:
4031:
4026:
4020:
4018:
4011:
4010:
4007:
4006:
4004:
4003:
3997:
3995:
3989:
3988:
3986:
3985:
3984:
3983:
3978:
3973:
3968:
3958:
3953:
3948:
3943:
3942:
3941:
3936:
3931:
3926:
3921:
3910:
3908:
3898:
3894:Extracellular
3891:
3890:
3887:
3886:
3884:
3883:
3878:
3873:
3868:
3862:
3860:
3856:
3855:
3853:
3852:
3851:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3794:
3792:
3785:
3784:
3782:
3781:
3776:
3775:
3774:
3769:
3764:
3763:
3762:
3757:
3752:
3747:
3737:
3726:
3724:
3717:
3716:
3714:
3713:
3708:
3703:
3698:
3692:
3690:
3683:
3682:
3680:
3679:
3678:
3677:
3672:
3662:
3657:
3652:
3651:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3593:Synaptotagmins
3590:
3585:
3580:
3575:
3574:
3573:
3568:
3563:
3558:
3553:
3552:
3551:
3546:
3536:
3531:
3521:
3516:
3511:
3506:
3505:
3504:
3499:
3494:
3489:
3484:
3474:
3468:
3466:
3456:
3455:
3453:
3452:
3451:
3450:
3445:
3435:
3434:
3433:
3428:
3423:
3412:
3410:
3406:
3405:
3403:
3402:
3401:
3400:
3390:
3384:
3382:
3376:
3375:
3373:
3372:
3367:
3362:
3356:
3354:
3345:
3341:Intracellular
3338:
3337:
3334:
3333:
3331:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3259:
3257:
3251:
3250:
3248:
3247:
3241:
3239:
3233:
3232:
3230:
3229:
3228:
3227:
3222:
3211:
3209:
3203:
3202:
3200:
3199:
3198:
3197:
3192:
3187:
3177:
3176:
3175:
3170:
3165:
3160:
3155:
3145:
3144:
3143:
3138:
3137:
3136:
3134:NMDA receptors
3131:
3126:
3124:AMPA receptors
3116:
3114:5-HT3 receptor
3105:
3103:
3097:
3096:
3094:
3093:
3092:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3000:
2998:
2989:
2983:
2982:
2971:Cell signaling
2969:
2967:
2966:
2959:
2952:
2944:
2935:
2934:
2932:
2931:
2925:
2918:
2916:
2910:
2903:
2901:
2895:
2888:
2885:
2882:
2881:
2878:
2876:
2875:
2868:
2861:
2853:
2844:
2843:
2841:
2840:
2835:
2829:
2827:
2823:
2822:
2820:
2819:
2814:
2809:
2807:thrombospondin
2804:
2802:thrombospondin
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2685:
2681:
2675:
2673:
2667:
2666:
2664:
2663:
2658:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2617:
2614:kringle domain
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2517:
2515:Angiopoietin 2
2511:
2509:
2503:
2502:
2497:
2495:
2494:
2487:
2480:
2472:
2466:
2465:
2453:
2452:External links
2450:
2448:
2447:
2417:
2382:
2345:
2310:
2290:(20): 9702–8.
2275:
2238:
2200:(18): 6892–6.
2185:
2142:
2107:
2072:
2043:
2000:
1963:
1930:
1910:(5): 1105–13.
1895:
1860:
1807:
1770:
1734:
1732:
1729:
1727:
1726:
1677:
1642:
1607:
1558:
1523:
1505:
1487:
1466:
1444:
1442:
1439:
1429:
1426:
1422:hydroxyapatite
1385:
1382:
1370:amino terminus
1353:
1350:
1333:
1330:
1275:
1274:
1271:
1270:
1265:
1255:
1254:
1248:
1247:
1244:
1243:
1241:
1239:
1232:
1231:
1224:
1217:
1213:
1212:
1209:
1208:
1194:
1193:
1187:
1184:
1183:
1165:
1164:
1158:
1154:
1153:
1150:
1149:
1135:
1134:
1128:
1125:
1124:
1106:
1105:
1099:
1095:
1094:
1091:
1090:
1082:
1081:
1075:
1072:
1071:
1063:
1062:
1056:
1050:
1049:
1046:
1045:
1037:
1036:
1030:
1027:
1026:
1018:
1017:
1011:
1005:
1004:
1001:
1000:
992:
991:
985:
982:
981:
973:
972:
966:
960:
959:
954:
949:
945:
944:
934:
933:
930:
929:
918:
917:
915:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
768:
766:
762:
761:
759:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
681:nuclear matrix
678:
673:
668:
662:
660:
656:
655:
653:
652:
647:
642:
637:
632:
627:
621:
619:
615:
614:
604:
603:
600:
599:
596:
595:
587:
586:
568:
562:
561:
558:
557:
549:
548:
545:
544:
542:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
498:
497:
486:
483:
482:
480:
479:
475:
471:
467:
466:spinal ganglia
463:
462:olfactory bulb
459:
455:
451:
447:
443:
439:
436:
435:
423:
422:
414:
403:
397:
396:
393:RNA expression
385:
384:
381:
380:
372:
368:
367:
359:
356:
351:
345:
344:
335:
328:
322:
318:
317:
312:
306:
305:
297:
296:
284:
283:
280:
279:
271:
267:
266:
258:
255:
250:
244:
243:
234:
227:
221:
217:
216:
209:
203:
202:
194:
193:
181:
180:
137:
133:
132:
124:
116:
115:
111:
110:
107:
106:
103:
102:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4659:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4632:Glycoproteins
4630:
4628:
4625:
4624:
4622:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4581:Thyroglobulin
4579:
4577:
4574:
4570:
4569:Glycophorin C
4567:
4565:
4562:
4560:
4557:
4556:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4451:
4449:
4445:
4435:
4432:
4431:
4429:
4427:
4423:
4417:
4414:
4412:
4409:
4407:
4404:
4403:
4401:
4399:
4395:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4350:
4347:
4346:
4344:
4342:
4338:
4332:
4329:
4327:
4324:
4323:
4321:
4319:
4315:
4311:
4305:
4302:
4300:
4297:
4295:
4292:
4291:
4289:
4287:
4283:
4279:
4276:
4274:
4273:Proteoglycans
4270:
4260:
4257:
4255:
4252:
4250:
4249:Peptidoglycan
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4231:
4229:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4125:
4123:
4121:
4117:
4114:
4112:
4108:
4104:
4103:glycopeptides
4100:
4099:glycoproteins
4096:
4092:
4085:
4080:
4078:
4073:
4071:
4066:
4065:
4062:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4034:C-type lectin
4032:
4030:
4027:
4025:
4022:
4021:
4019:
4017:
4012:
4002:
3999:
3998:
3996:
3994:
3990:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3963:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3916:
3915:
3912:
3911:
3909:
3906:
3902:
3899:
3897:
3892:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3863:
3861:
3857:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3800:
3799:
3796:
3795:
3793:
3791:
3786:
3780:
3777:
3773:
3770:
3768:
3765:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3736:
3733:
3732:
3731:
3728:
3727:
3725:
3723:
3718:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3693:
3691:
3689:
3684:
3676:
3673:
3671:
3668:
3667:
3666:
3663:
3661:
3658:
3656:
3653:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3595:
3594:
3591:
3589:
3586:
3584:
3583:Phospholamban
3581:
3579:
3576:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3550:
3547:
3545:
3542:
3541:
3540:
3537:
3535:
3532:
3530:
3527:
3526:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3509:Calsequestrin
3507:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3479:
3478:
3475:
3473:
3470:
3469:
3467:
3465:
3461:
3457:
3449:
3446:
3444:
3441:
3440:
3439:
3436:
3432:
3429:
3427:
3424:
3422:
3419:
3418:
3417:
3414:
3413:
3411:
3407:
3399:
3396:
3395:
3394:
3391:
3389:
3386:
3385:
3383:
3381:
3377:
3371:
3368:
3366:
3363:
3361:
3358:
3357:
3355:
3353:
3349:
3346:
3344:
3339:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3260:
3258:
3256:
3252:
3246:
3243:
3242:
3240:
3238:
3234:
3226:
3223:
3221:
3218:
3217:
3216:
3213:
3212:
3210:
3208:
3207:Calcium pumps
3204:
3196:
3193:
3191:
3188:
3186:
3183:
3182:
3181:
3178:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3150:
3149:
3148:Voltage-gated
3146:
3142:
3141:P2X receptors
3139:
3135:
3132:
3130:
3127:
3125:
3122:
3121:
3120:
3117:
3115:
3112:
3111:
3110:
3107:
3106:
3104:
3102:
3098:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3006:
3005:
3002:
3001:
2999:
2997:
2993:
2990:
2988:
2987:Cell membrane
2984:
2980:
2976:
2972:
2965:
2960:
2958:
2953:
2951:
2946:
2945:
2942:
2928:
2922:
2917:
2913:
2907:
2902:
2898:
2892:
2887:
2883:
2874:
2869:
2867:
2862:
2860:
2855:
2854:
2851:
2839:
2836:
2834:
2831:
2830:
2828:
2824:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2682:
2680:
2677:
2676:
2674:
2672:
2668:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2621:
2618:
2615:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2512:
2510:
2508:
2504:
2500:
2493:
2488:
2486:
2481:
2479:
2474:
2473:
2470:
2463:
2459:
2456:
2455:
2451:
2444:
2440:
2436:
2432:
2429:(2): 347–57.
2428:
2424:
2418:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2383:
2379:
2375:
2371:
2367:
2363:
2359:
2355:
2351:
2346:
2342:
2338:
2333:
2328:
2324:
2320:
2316:
2311:
2307:
2303:
2298:
2293:
2289:
2285:
2281:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2249:(2): 409–15.
2248:
2244:
2239:
2235:
2231:
2226:
2221:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2186:
2182:
2178:
2174:
2170:
2165:
2160:
2156:
2152:
2148:
2143:
2139:
2135:
2130:
2125:
2122:(2): 275–84.
2121:
2117:
2113:
2108:
2104:
2100:
2095:
2090:
2087:(2): 345–55.
2086:
2082:
2078:
2073:
2069:
2065:
2061:
2057:
2053:
2049:
2044:
2040:
2036:
2031:
2026:
2022:
2018:
2015:(1): 341–56.
2014:
2010:
2006:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1974:(3): 146–52.
1973:
1969:
1964:
1960:
1956:
1952:
1948:
1944:
1940:
1936:
1931:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1896:
1892:
1888:
1883:
1878:
1875:(2): 283–91.
1874:
1870:
1866:
1861:
1857:
1853:
1848:
1843:
1838:
1833:
1829:
1825:
1822:(4): 1281–5.
1821:
1817:
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1771:
1767:
1763:
1758:
1753:
1749:
1745:
1741:
1736:
1735:
1730:
1722:
1718:
1714:
1710:
1705:
1700:
1697:(2): 163–73.
1696:
1692:
1691:FASEB Journal
1688:
1681:
1678:
1673:
1669:
1665:
1661:
1657:
1653:
1646:
1643:
1638:
1634:
1630:
1626:
1622:
1618:
1611:
1608:
1603:
1599:
1594:
1589:
1585:
1581:
1578:(2): 224–34.
1577:
1573:
1569:
1562:
1559:
1554:
1550:
1546:
1542:
1538:
1534:
1527:
1524:
1519:
1515:
1509:
1506:
1501:
1497:
1491:
1488:
1484:
1480:
1475:
1473:
1471:
1467:
1463:
1459:
1454:
1452:
1450:
1446:
1440:
1438:
1434:
1427:
1425:
1423:
1417:
1413:
1411:
1407:
1406:proliferation
1403:
1399:
1395:
1391:
1383:
1381:
1379:
1376:motif at the
1375:
1371:
1367:
1366:glutamic acid
1363:
1359:
1351:
1349:
1347:
1343:
1339:
1331:
1329:
1327:
1323:
1319:
1315:
1311:
1307:
1302:
1300:
1297:
1293:
1290:(BM-40) is a
1289:
1285:
1281:
1269:
1264:
1260:
1256:
1253:
1249:
1242:
1240:
1237:
1233:
1229:
1225:
1222:
1218:
1214:
1207:
1205:
1201:
1195:
1191:
1188:
1182:
1180:
1176:
1172:
1166:
1162:
1159:
1155:
1148:
1146:
1142:
1136:
1132:
1129:
1123:
1121:
1117:
1113:
1107:
1103:
1100:
1098:RefSeq (mRNA)
1096:
1089:
1088:
1083:
1079:
1076:
1070:
1069:
1064:
1060:
1057:
1055:
1051:
1044:
1043:
1038:
1034:
1031:
1025:
1024:
1019:
1015:
1012:
1010:
1006:
999:
998:
993:
989:
986:
980:
979:
974:
970:
967:
965:
961:
958:
955:
953:
950:
946:
943:
939:
935:
928:
924:
919:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
822:wound healing
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
769:
767:
764:
763:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
711:mitochondrion
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
622:
620:
617:
616:
613:
612:Gene ontology
609:
605:
593:
588:
584:
577:
572:
569:
567:
563:
555:
550:
539:
535:
531:
527:
523:
519:
515:
511:
508:body of femur
507:
503:
502:
499:
495:
490:
487:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
440:
437:
433:
428:
425:
424:
421:
419:
415:
413:
412:
408:
407:
404:
402:
398:
394:
390:
386:
378:
373:
369:
365:
360:
350:
346:
339:
332:
326:
319:
311:
307:
303:
298:
294:
289:
285:
277:
272:
268:
264:
259:
249:
245:
238:
231:
225:
218:
214:
208:
204:
200:
195:
191:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
134:
129:
122:
117:
112:
101:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
26:
22:
4533:
4494:4-1BB ligand
4406:Fibromodulin
4111:Mucoproteins
3955:
3946:Hemicentin 1
3696:Calreticulin
3588:Sarcalumenin
3388:IP3 receptor
3180:TRP channels
3109:Ligand-gated
2926:
2911:
2896:
2833:Angiogenesis
2747:itraconazole
2625:
2530:calreticulin
2426:
2422:
2394:
2390:
2353:
2349:
2322:
2318:
2287:
2283:
2246:
2242:
2197:
2193:
2157:(2): 352–6.
2154:
2151:FEBS Letters
2150:
2119:
2115:
2084:
2080:
2054:(1): 37–47.
2051:
2047:
2012:
2008:
1971:
1967:
1945:(1): 17–28.
1942:
1938:
1907:
1903:
1872:
1868:
1819:
1815:
1778:
1774:
1747:
1743:
1694:
1690:
1680:
1655:
1651:
1645:
1623:(6): 470–8.
1620:
1616:
1610:
1575:
1571:
1561:
1536:
1533:Biochemistry
1532:
1526:
1517:
1508:
1499:
1490:
1435:
1431:
1418:
1414:
1402:angiogenesis
1387:
1355:
1335:
1306:glycoprotein
1303:
1295:
1287:
1283:
1279:
1278:
1200:NP_001277746
1197:
1175:NP_001296373
1171:NP_001296372
1168:
1145:NM_001290817
1138:
1120:NM_001309444
1116:NM_001309443
1109:
1085:
1066:
1040:
1021:
995:
976:
956:
951:
907:pigmentation
782:ossification
701:cell surface
536:carotid body
516:aortic valve
416:
409:
274:151,686,975
261:151,661,096
136:External IDs
83:
4606:Vitronectin
4601:Uteroglobin
4591:Transcortin
4564:Glycophorin
4534:Osteonectin
4519:Lactoferrin
4244:Orosomucoid
4234:Haptoglobin
4001:Osteocalcin
3981:Osteopontin
3956:Osteonectin
3730:CaM kinases
3578:Parvalbumin
3561:Neurocalcin
3556:Hippocalcin
2879:PDB gallery
2797:thalidomide
2782:tasquinimod
2712:bevacizumab
2707:angiostatin
2610:prothrombin
2590:osteopontin
2520:angiostatin
2458:Osteonectin
1394:cell-matrix
1360:acidic and
1314:osteoblasts
1286:(SPARC) or
1280:Osteonectin
454:gallbladder
375:55,314,009
362:55,285,326
114:Identifiers
25:Osteopontin
21:Osteocalcin
4621:Categories
4434:Syndecan 1
4049:Gla domain
3866:Calcitonin
3688:chaperones
3665:Troponin C
3529:Calsenilin
3514:Calretinin
3477:Calmodulin
2732:endostatin
2692:inhibitors
2641:vasostatin
2535:endostatin
2507:Endogenous
1485:, May 2017
1464:, May 2017
1441:References
524:belly cord
420:(ortholog)
157:HomoloGene
4544:Protein S
4539:Protein C
4514:Hemopexin
4504:Clusterin
4416:Keratocan
4024:C2 domain
3896:chelators
3881:Vitamin K
3876:Vitamin D
3790:proteases
3566:Recoverin
3534:Frequenin
3472:Calbindin
3464:chelators
3343:signaling
3004:Cadherins
2787:tecogalan
2767:prolactin
2671:Exogenous
2600:prolactin
2525:canstatin
1410:migration
1352:Structure
1204:NP_033268
1179:NP_003109
1141:NM_009242
1112:NM_003118
942:Orthologs
666:cytoplasm
165:GeneCards
4363:Brevican
4358:Neurocan
4353:Aggrecan
4331:Perlecan
4326:Testican
4304:Versican
4299:Biglycan
4259:Ovomucin
4029:Cadherin
3961:SIBLINGs
3914:Fibulins
3907:proteins
3798:Calpains
3701:Calnexin
3519:Gelsolin
3255:Annexins
2826:See also
2752:linomide
2622:fragment
2271:38472373
2181:22117205
2048:Genomics
1996:32528538
1803:35426082
1766:10567433
1721:32958146
1602:16041213
1481:–
1460:–
1384:Function
1362:cysteine
1318:collagen
1252:Wikidata
921:Sources:
540:gastrula
504:calvaria
4411:Lumican
4294:Decorin
4091:Protein
4039:EF hand
4016:domains
3722:kinases
3711:HSP90B1
3571:Visinin
3460:Sensors
3448:SLC24A5
2812:TNP-470
2777:suramin
2702:heparin
2443:7563094
2413:7559469
2378:1625045
2370:7034958
2341:6368555
2306:3597437
2263:3581152
2234:3489235
2202:Bibcode
2173:3410046
2138:3402455
2103:3400777
2094:1880722
2068:2838412
2039:2745554
2030:2115491
1988:2505905
1959:2338025
1926:2306517
1891:1552170
1856:1311092
1824:Bibcode
1795:1093755
1713:8119487
1672:1499220
1637:6380686
1593:1357728
1553:2790009
1483:Ensembl
1462:Ensembl
1374:EF hand
1346:introns
1308:in the
1292:protein
1054:UniProt
1009:Ensembl
948:Species
927:QuickGO
746:synapse
731:vesicle
721:nucleus
395:pattern
121:Aliases
4484:Avidin
4163:MUC5AC
3848:CAPN10
3502:CALML5
3497:CALML3
3443:SLC8B1
3431:ATP2A3
3426:ATP2A2
3421:ATP2A1
3225:SLC8A1
3220:SLC3A2
2772:SU5416
2585:Meth-2
2580:Meth-1
2575:maspin
2555:CXCL10
2464:(MeSH)
2441:
2411:
2376:
2368:
2339:
2304:
2269:
2261:
2232:
2225:386616
2222:
2179:
2171:
2136:
2101:
2091:
2066:
2037:
2027:
1994:
1986:
1957:
1924:
1889:
1854:
1844:
1801:
1793:
1764:
1719:
1711:
1670:
1635:
1600:
1590:
1551:
1344:and 9
1238:search
1236:PubMed
1087:P07214
1068:P09486
964:Entrez
566:BioGPS
253:5q33.1
145:182120
4447:Other
4378:CSPG5
4373:CSPG4
4227:Other
4218:MUC20
4213:MUC19
4208:MUC17
4203:MUC16
4198:MUC15
4193:MUC13
4188:MUC12
4168:MUC5B
4153:MUC3B
4148:MUC3A
4133:CD164
4120:Mucin
3939:FBLN5
3934:FBLN4
3929:FBLN3
3924:FBLN2
3919:FBLN1
3843:CAPN9
3838:CAPN8
3833:CAPN7
3828:CAPN6
3823:CAPN5
3818:CAPN4
3813:CAPN3
3808:CAPN2
3803:CAPN1
3772:CAMK4
3767:CAMK3
3740:CAMK2
3735:CAMK1
3706:HSPA5
3675:TNNC2
3670:TNNC1
3660:S100P
3648:SYT14
3643:SYT13
3638:SYT11
3492:CALM3
3487:CALM2
3482:CALM1
3416:SERCA
3370:cADPR
3365:NAADP
3303:A8-L2
3237:GPCRs
3089:CDH17
3084:CDH16
3079:CDH15
3074:CDH14
3069:CDH13
3064:CDH12
3059:CDH11
3054:CDH10
2742:IL-12
2737:IFN-α
2727:CM101
2656:NRP-1
2626:SPARC
2570:IL-18
2565:IL-12
2550:IFN-γ
2545:IFN-β
2540:IFN-α
2374:S2CID
2267:S2CID
2177:S2CID
1992:S2CID
1904:Blood
1847:48433
1799:S2CID
1717:S2CID
1342:exons
1296:SPARC
997:20692
957:Mouse
952:Human
923:Amigo
442:tibia
418:Mouse
411:Human
358:Start
293:Mouse
257:Start
190:Human
169:SPARC
161:31132
153:98373
128:SPARC
33:SPARC
4559:CD43
4474:CD70
4459:ADAM
4368:CD44
4183:MUC8
4178:MUC7
4173:MUC6
4158:MUC4
4143:MUC2
4138:MUC1
4128:CD43
4101:and
3655:S100
3633:SYT9
3628:SYT7
3623:SYT6
3618:SYT5
3613:SYT4
3608:SYT3
3603:SYT2
3598:SYT1
3539:GUCA
3462:and
3195:TRPV
3190:TRPC
3185:TRPA
3049:CDH9
3044:CDH8
3039:CDH7
3034:CDH6
3029:CDH5
3024:CDH4
3019:CDH3
3014:CDH2
3009:CDH1
2977:and
2927:1sra
2912:1nub
2897:1bmo
2661:CDAI
2646:VEGI
2636:TIMP
2560:IL-4
2439:PMID
2409:PMID
2366:PMID
2350:Cell
2337:PMID
2302:PMID
2259:PMID
2230:PMID
2169:PMID
2134:PMID
2099:PMID
2064:PMID
2035:PMID
1984:PMID
1955:PMID
1922:PMID
1887:PMID
1852:PMID
1791:PMID
1762:PMID
1709:PMID
1668:PMID
1633:PMID
1598:PMID
1549:PMID
1408:and
1332:Gene
1324:and
1310:bone
1299:gene
978:6678
401:Bgee
349:Band
310:Chr.
248:Band
207:Chr.
141:OMIM
98:2V53
94:1SRA
90:1NUB
86:1BMO
67:RCSB
64:PDBe
3360:IP3
3328:A13
3323:A12
3318:A11
3313:A10
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2431:doi
2427:253
2399:doi
2395:270
2358:doi
2327:doi
2323:259
2292:doi
2288:262
2251:doi
2247:248
2220:PMC
2210:doi
2159:doi
2155:236
2124:doi
2120:175
2089:PMC
2085:132
2056:doi
2025:PMC
2017:doi
2013:109
1976:doi
1947:doi
1912:doi
1877:doi
1842:PMC
1832:doi
1783:doi
1752:doi
1699:doi
1660:doi
1656:281
1625:doi
1588:PMC
1580:doi
1576:242
1541:doi
1358:kDa
371:End
270:End
173:OMA
149:MGI
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4398:KS
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4318:CS
4314:HS
4286:DS
4282:CS
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3308:A9
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