242:
219:
116:
141:
493:
500:
507:
248:
147:
1003:. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. The function of Atrophin-1 has not yet been determined. There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional
2362:
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de
Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000).
1082:
In patients with DRPLA, truncated ATN1 has been observed forming intranuclear aggregates that cause cell death. The symptoms of this disorder can be credited to the significant reduction of brain and spinal tissue observed in those afflicted with DRPLA. There are both juvenile-onset and late
2254:
Hayashi Y, Kakita A, Yamada M, Koide R, Igarashi S, Takano H, Ikeuchi T, Wakabayashi K, Egawa S, Tsuji S, Takahashi H (December 1998). "Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain".
1039:
The ATN1 gene has a segment of DNA called the CAG trinucleotide repeat. It is made up of cytosine, adenine, and guanine. The number of CAG repeats in the ATN1 gene in a healthy person will range from six to thirty-five repeats. CAG repeats that exceed thirty-five can cause a
2034:
Yanagisawa H, Fujii K, Nagafuchi S, Nakahori Y, Nakagome Y, Akane A, Nakamura M, Sano A, Komure O, Kondo I, Jin DK, Sørensen SA, Potter NT, Young SR, Nakamura K, Nukina N, Nagao Y, Tadokoro K, Okuyama T, Miyashita T, Inoue T, Kanazawa I, Yamada M (March 1996).
2175:
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR (April 1998).
1859:
Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N (January 1994). "Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p".
1783:
Nagafuchi S, Yanagisawa H, Ohsaki E, Shirayama T, Tadokoro K, Inoue T, Yamada M (October 1994). "Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)".
1897:
Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T (January 1994). "Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)".
1821:
Burke JR, Wingfield MS, Lewis KE, Roses AD, Lee JE, Hulette C, Pericak-Vance MA, Vance JM (August 1994). "The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an
African-American family".
2294:"Single sperm analysis of the CAG repeats in the gene for dentatorubral-pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases"
1048:(NES). It has been shown that a mutation of the NES in ATN1 can change where ATN1 localizes, and can cause aggregation to occur in the nucleus. This can lead to an increase in cellular toxicity.
1044:
in ATN1. Studies have supported the idea that mutated
Atrophin-1 gathers in neurons and disrupts cell function. The sequence of the ATN1 gene contains a nuclear localizing signal (NLS) and a
2005:
Takano T, Yamanouchi Y, Nagafuchi S, Yamada M (February 1996). "Assignment of the dentatorubral and pallidoluysian atrophy (DRPLA) gene to 12p 13.31 by fluorescence in situ hybridization".
2329:"Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate"
1529:"Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate"
1746:
Yazawa I, Nukina N, Hashida H, Goto J, Yamada M, Kanazawa I (May 1995). "Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain".
255:
154:
725:
706:
77:
1272:"Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription"
2178:"Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract"
1713:"Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS"
2502:
1204:
1186:
1056:
2507:
241:
940:
2474:
933:
218:
1251:
1173:
1152:
1019:
The function of
Atrophin-1 has not been defined yet. It is widely hypothesized that Atrophin-1 functions as a transcriptional
140:
115:
1169:
2480:
2418:"Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine"
1624:"Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine"
1052:
1148:
57:
1092:
2211:
Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (June 1998).
1573:
Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (June 1998).
254:
153:
247:
146:
2467:
2107:"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination"
1270:
Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA (September 2000).
770:
65:
751:
2458:
1045:
129:
1007:. Atrophin-1 can be found in the nuclear and cytoplasmic compartments of neurons. It is expressed in
2376:
1937:"Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms"
44:
2486:
1972:"A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13"
1028:
891:
844:
2213:"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins"
2070:
Margolis RL, Li SH, Young WS, Wagster MV, Stine OC, Kidwai AS, Ashworth RG, Ross CA (March 1996).
1575:"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins"
1059:" or "dentatorubropallidoluysian atrophy". Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare
2280:
2242:
1923:
1885:
1847:
1809:
1771:
1604:
1358:
1068:
89:
2416:
Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000).
1622:
Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000).
916:
895:
865:
840:
2142:"Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis"
2439:
2404:
2350:
2315:
2272:
2234:
2199:
2163:
2128:
2093:
2058:
2022:
1993:
1958:
1915:
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1839:
1801:
1763:
1734:
1699:
1645:
1596:
1550:
1482:
1432:
1350:
1301:
1083:
adult-onset variants of DRPLA, which show differing degrees of severity of specific symptoms.
1064:
1060:
37:
2429:
2394:
2384:
2340:
2305:
2264:
2224:
2189:
2153:
2118:
2083:
2048:
2037:"A unique origin and multistep process for the generation of expanded DRPLA triplet repeats"
2014:
1983:
1970:
Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (April 1996).
1948:
1907:
1869:
1831:
1793:
1755:
1724:
1689:
1681:
1635:
1586:
1540:
1472:
1422:
1340:
1332:
1291:
1283:
492:
334:
265:
209:
164:
1027:
is a protein that indirectly suppresses the activity of specific genes by interacting with
1072:
499:
309:
85:
2380:
1345:
1320:
506:
2292:
Takiyama Y, Sakoe K, Amaike M, Soutome M, Ogawa T, Nakano I, Nishizawa M (March 1999).
1729:
1712:
1694:
1669:
1477:
1460:
1296:
1271:
1079:. The disorder is related to the expansion of a trinucleotide repeat within this gene.
1008:
2463:
640:
635:
630:
625:
620:
604:
599:
594:
589:
584:
579:
563:
558:
553:
548:
2496:
2399:
2364:
2088:
2071:
1670:"Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors"
535:
2284:
2246:
1927:
1889:
1851:
1608:
1362:
1813:
1775:
1385:
1024:
1020:
1004:
327:
106:
69:
1503:
93:
2365:"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"
1461:"Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy"
1209:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1191:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2369:
Proceedings of the
National Academy of Sciences of the United States of America
410:
1711:
Onodera O, Oyake M, Takano H, Ikeuchi T, Igarashi S, Tsuji S (November 1995).
1336:
226:
123:
73:
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2141:
2194:
2177:
670:
470:
348:
293:
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192:
179:
81:
2443:
2434:
2417:
2408:
2389:
2354:
2229:
2212:
2140:
Miyashita T, Okamura-Oho Y, Mito Y, Nagafuchi S, Yamada M (November 1997).
2018:
1953:
1936:
1703:
1649:
1640:
1623:
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1574:
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2132:
2097:
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2053:
2036:
2026:
1997:
1962:
1919:
1881:
1843:
1805:
1767:
1738:
1600:
1545:
1528:
1287:
980:
975:
1227:
1076:
1041:
964:
815:
796:
1685:
1321:"Atrophins' emerging roles in development and neurodegenerative disease"
2123:
2106:
1988:
1971:
1835:
1797:
996:
782:
737:
1873:
1759:
2072:"DRPLA gene (atrophin-1) sequence and mRNA expression in human brain"
1935:
Li SH, McInnis MG, Margolis RL, Antonarakis SE, Ross CA (June 1993).
1911:
1099:
948:
692:
1409:
Shen Y, Lee G, Choe Y, Zoltewicz JS, Peterson AS (February 2007).
1111:
1105:
655:
651:
2105:
Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (March 1997).
1123:
1117:
1000:
61:
515:
1228:"ATN1 atrophin 1 [Homo sapiens (human)] - Gene - NCBI"
1668:
Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC (March 2006).
1498:
1496:
1465:
International
Journal of Clinical and Experimental Pathology
2327:
Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (June 1999).
1527:
Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (June 1999).
636:
negative regulation of transcription by RNA polymerase II
317:
482:
48:, B37, D12S755E, DRPLA, HRS, NOD, atrophin 1, CHEDDA
909:
884:
858:
833:
437:
dentate gyrus of hippocampal formation granule cell
1165:
1163:
1161:
1144:
1142:
1140:
264:
163:
1051:Mutations in ATN1 are associated with a form of
1568:
1566:
1564:
1454:
1452:
1450:
1448:
1446:
1170:GRCm38: Ensembl release 89: ENSMUSG00000004263
1504:"Dentatorubral-Pallidoluysian Atrophy, DRPLA"
1222:
1220:
1218:
8:
1265:
1263:
1261:
1149:GRCh38: Ensembl release 89: ENSG00000111676
666:
631:regulation of transcription, DNA-templated
531:
305:
204:
101:
2466:at the U.S. National Library of Medicine
2433:
2398:
2388:
2344:
2309:
2228:
2193:
2157:
2122:
2087:
2052:
1987:
1952:
1728:
1693:
1639:
1590:
1544:
1476:
1426:
1344:
1295:
2076:Brain Research. Molecular Brain Research
1136:
2459:GeneReviews/NCBI/NIH/UW entry on DRPLA
1411:"Functional architecture of atrophins"
999:that in humans is encoded by the ATN1
18:
1380:
1378:
1376:
1374:
1372:
1319:Shen Y, Peterson AS (February 2009).
269:
230:
225:
168:
127:
122:
7:
2217:Molecular and Cellular Neurosciences
1579:Molecular and Cellular Neurosciences
1325:Cellular and Molecular Life Sciences
1057:dentatorubral-pallidoluysian atrophy
2182:The Journal of Biological Chemistry
2146:The Journal of Biological Chemistry
1415:The Journal of Biological Chemistry
1717:American Journal of Human Genetics
906:
881:
855:
830:
806:
787:
761:
742:
716:
697:
626:central nervous system development
554:transcription corepressor activity
487:
405:
343:
322:
14:
1459:Suzuki Y, Yazawa I (April 2011).
505:
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
585:perinuclear region of cytoplasm
559:protein domain specific binding
1508:themedicalbiochemistrypage.org
1252:"Entrez Gene: ATN1 atrophin 1"
516:More reference expression data
471:More reference expression data
359:right hemisphere of cerebellum
1:
1053:trinucleotide repeat disorder
238:
137:
2503:Genes on human chromosome 12
2089:10.1016/0169-328X(95)00241-J
641:transcription, DNA-templated
1276:The Journal of Cell Biology
379:right lobe of thyroid gland
2524:
2508:Transcription coregulators
2485:gene details page in the
1063:disorder characterized by
383:left lobe of thyroid gland
1337:10.1007/s00018-008-8403-9
1205:"Mouse PubMed Reference:"
1187:"Human PubMed Reference:"
1042:gain-of-function mutation
979:
974:
970:
963:
947:
941:Chr 6: 124.72 – 124.73 Mb
928:
913:
888:
877:
862:
837:
826:
813:
809:
794:
790:
781:
768:
764:
749:
745:
736:
723:
719:
704:
700:
691:
676:
669:
665:
649:
534:
530:
513:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
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186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2468:Medical Subject Headings
2422:Human Molecular Genetics
2333:Human Molecular Genetics
2298:Human Molecular Genetics
2159:10.1074/jbc.272.46.29238
2041:Human Molecular Genetics
1628:Human Molecular Genetics
1533:Human Molecular Genetics
621:neuron apoptotic process
2195:10.1074/jbc.273.15.9158
1674:Genes & Development
1390:Genetics Home Reference
1091:ATN1 has been shown to
16:Protein found in humans
2390:10.1073/pnas.97.7.3491
2230:10.1006/mcne.1998.0677
2019:10.1006/geno.1996.0100
1954:10.1006/geno.1993.1232
1592:10.1006/mcne.1998.0677
1428:10.1074/jbc.M610274200
934:Chr 12: 6.92 – 6.94 Mb
429:superior frontal gyrus
421:neural layer of retina
2269:10.1007/s004010050933
2257:Acta Neuropathologica
1288:10.1083/jcb.150.5.939
1046:nuclear export signal
1035:Clinical significance
425:primary visual cortex
130:Chromosome 12 (human)
2479:genome location and
2435:10.1093/hmg/9.9.1433
1641:10.1093/hmg/9.9.1433
1232:www.ncbi.nlm.nih.gov
1029:DNA-binding proteins
1023:. A transcriptional
271:6 F2|6 59.17 cM
232:Chromosome 6 (mouse)
2487:UCSC Genome Browser
2381:2000PNAS...97.3491D
2346:10.1093/hmg/8.6.947
2311:10.1093/hmg/8.3.453
2054:10.1093/hmg/5.3.373
1686:10.1101/gad.1393506
1546:10.1093/hmg/8.6.947
395:canal of the cervix
2124:10.1101/gr.7.3.268
1989:10.1101/gr.6.4.314
1836:10.1038/ng0894-521
1798:10.1038/ng1094-177
1069:myoclonic epilepsy
771:ENSMUSG00000004263
614:Biological process
573:Cellular component
542:Molecular function
371:right uterine tube
363:anterior pituitary
1874:10.1038/ng0194-14
1760:10.1038/ng0595-99
1065:cerebellar ataxia
1061:neurodegenerative
990:
989:
986:
985:
959:
958:
924:
923:
903:
902:
873:
872:
852:
851:
822:
821:
803:
802:
777:
776:
758:
757:
732:
731:
713:
712:
661:
660:
526:
525:
522:
521:
477:
476:
464:
463:
441:cerebellar cortex
402:
401:
300:
299:
199:
198:
2515:
2447:
2437:
2412:
2402:
2392:
2358:
2348:
2323:
2313:
2288:
2250:
2232:
2207:
2197:
2171:
2161:
2152:(46): 29238–42.
2136:
2126:
2101:
2091:
2066:
2056:
2030:
2001:
1991:
1966:
1956:
1931:
1912:10.1038/ng0194-9
1893:
1855:
1817:
1779:
1742:
1732:
1707:
1697:
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1524:
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1400:
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1382:
1367:
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1348:
1316:
1310:
1309:
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1224:
1213:
1212:
1201:
1195:
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1183:
1177:
1167:
1156:
1146:
972:
971:
943:
936:
919:
907:
898:
882:
878:RefSeq (protein)
868:
856:
847:
831:
807:
788:
762:
743:
717:
698:
667:
532:
518:
509:
502:
495:
488:
473:
453:ventricular zone
433:genital tubercle
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:ATN1 - orthologs
47:
40:
19:
2523:
2522:
2518:
2517:
2516:
2514:
2513:
2512:
2493:
2492:
2455:
2450:
2415:
2361:
2326:
2291:
2253:
2210:
2188:(15): 9158–67.
2174:
2139:
2111:Genome Research
2104:
2069:
2033:
2004:
1976:Genome Research
1969:
1934:
1900:Nature Genetics
1896:
1862:Nature Genetics
1858:
1824:Nature Genetics
1820:
1786:Nature Genetics
1782:
1748:Nature Genetics
1745:
1710:
1667:
1663:
1661:Further reading
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1236:
1234:
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1202:
1198:
1185:
1184:
1180:
1168:
1159:
1147:
1138:
1133:
1089:
1073:choreoathetosis
1037:
1017:
981:View/Edit Mouse
976:View/Edit Human
939:
932:
929:Location (UCSC)
915:
894:
890:
864:
843:
839:
752:ENSG00000111676
645:
609:
568:
549:protein binding
514:
504:
503:
497:
496:
469:
460:
455:
451:
447:
445:muscle of thigh
443:
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431:
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208:Gene location (
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177:
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128:
105:Gene location (
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43:
36:
17:
12:
11:
5:
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2453:External links
2451:
2449:
2448:
2428:(9): 1433–42.
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2002:
1967:
1932:
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1780:
1743:
1723:(5): 1050–60.
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1656:
1655:
1634:(9): 1433–42.
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1492:
1442:
1421:(7): 5037–44.
1401:
1368:
1311:
1257:
1243:
1214:
1196:
1178:
1157:
1135:
1134:
1132:
1129:
1128:
1127:
1121:
1115:
1109:
1103:
1088:
1085:
1036:
1033:
1016:
1013:
1009:nervous tissue
988:
987:
984:
983:
978:
968:
967:
961:
960:
957:
956:
954:
952:
945:
944:
937:
930:
926:
925:
922:
921:
911:
910:
904:
901:
900:
886:
885:
879:
875:
874:
871:
870:
860:
859:
853:
850:
849:
835:
834:
828:
824:
823:
820:
819:
811:
810:
804:
801:
800:
792:
791:
785:
779:
778:
775:
774:
766:
765:
759:
756:
755:
747:
746:
740:
734:
733:
730:
729:
721:
720:
714:
711:
710:
702:
701:
695:
689:
688:
683:
678:
674:
673:
663:
662:
659:
658:
647:
646:
644:
643:
638:
633:
628:
623:
617:
615:
611:
610:
608:
607:
602:
597:
592:
587:
582:
580:nuclear matrix
576:
574:
570:
569:
567:
566:
561:
556:
551:
545:
543:
539:
538:
528:
527:
524:
523:
520:
519:
511:
510:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
457:tail of embryo
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
391:gastric mucosa
388:
387:body of uterus
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2520:
2509:
2506:
2504:
2501:
2500:
2498:
2488:
2484:
2483:
2478:
2477:
2472:
2469:
2465:
2462:
2460:
2457:
2456:
2452:
2445:
2441:
2436:
2431:
2427:
2423:
2419:
2414:
2410:
2406:
2401:
2396:
2391:
2386:
2382:
2378:
2375:(7): 3491–6.
2374:
2370:
2366:
2360:
2356:
2352:
2347:
2342:
2339:(6): 947–57.
2338:
2334:
2330:
2325:
2321:
2317:
2312:
2307:
2303:
2299:
2295:
2290:
2286:
2282:
2278:
2274:
2270:
2266:
2263:(6): 547–52.
2262:
2258:
2252:
2248:
2244:
2240:
2236:
2231:
2226:
2223:(3): 149–60.
2222:
2218:
2214:
2209:
2205:
2201:
2196:
2191:
2187:
2183:
2179:
2173:
2169:
2165:
2160:
2155:
2151:
2147:
2143:
2138:
2134:
2130:
2125:
2120:
2117:(3): 268–80.
2116:
2112:
2108:
2103:
2099:
2095:
2090:
2085:
2082:(2): 219–26.
2081:
2077:
2073:
2068:
2064:
2060:
2055:
2050:
2046:
2042:
2038:
2032:
2028:
2024:
2020:
2016:
2012:
2008:
2003:
1999:
1995:
1990:
1985:
1982:(4): 314–26.
1981:
1977:
1973:
1968:
1964:
1960:
1955:
1950:
1946:
1942:
1938:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1901:
1895:
1891:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1825:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1792:(2): 177–82.
1791:
1787:
1781:
1777:
1773:
1769:
1765:
1761:
1757:
1754:(1): 99–103.
1753:
1749:
1744:
1740:
1736:
1731:
1726:
1722:
1718:
1714:
1709:
1705:
1701:
1696:
1691:
1687:
1683:
1680:(5): 525–30.
1679:
1675:
1671:
1666:
1665:
1660:
1651:
1647:
1642:
1637:
1633:
1629:
1625:
1618:
1615:
1610:
1606:
1602:
1598:
1593:
1588:
1585:(3): 149–60.
1584:
1580:
1576:
1569:
1567:
1565:
1561:
1556:
1552:
1547:
1542:
1539:(6): 947–57.
1538:
1534:
1530:
1523:
1520:
1509:
1505:
1499:
1497:
1493:
1488:
1484:
1479:
1474:
1471:(4): 378–84.
1470:
1466:
1462:
1455:
1453:
1451:
1449:
1447:
1443:
1438:
1434:
1429:
1424:
1420:
1416:
1412:
1405:
1402:
1391:
1387:
1381:
1379:
1377:
1375:
1373:
1369:
1364:
1360:
1356:
1352:
1347:
1342:
1338:
1334:
1331:(3): 437–46.
1330:
1326:
1322:
1315:
1312:
1307:
1303:
1298:
1293:
1289:
1285:
1282:(5): 939–48.
1281:
1277:
1273:
1266:
1264:
1262:
1258:
1253:
1247:
1244:
1233:
1229:
1223:
1221:
1219:
1215:
1210:
1206:
1200:
1197:
1192:
1188:
1182:
1179:
1175:
1171:
1166:
1164:
1162:
1158:
1154:
1150:
1145:
1143:
1141:
1137:
1130:
1125:
1122:
1119:
1116:
1113:
1110:
1107:
1104:
1101:
1098:
1097:
1096:
1094:
1086:
1084:
1081:
1078:
1074:
1070:
1066:
1062:
1058:
1054:
1049:
1047:
1043:
1034:
1032:
1030:
1026:
1022:
1014:
1012:
1010:
1006:
1002:
998:
994:
982:
977:
973:
969:
966:
962:
955:
953:
950:
946:
942:
938:
935:
931:
927:
920:
918:
912:
908:
905:
899:
897:
893:
887:
883:
880:
876:
869:
867:
861:
857:
854:
848:
846:
842:
836:
832:
829:
827:RefSeq (mRNA)
825:
818:
817:
812:
808:
805:
799:
798:
793:
789:
786:
784:
780:
773:
772:
767:
763:
760:
754:
753:
748:
744:
741:
739:
735:
728:
727:
722:
718:
715:
709:
708:
703:
699:
696:
694:
690:
687:
684:
682:
679:
675:
672:
668:
664:
657:
653:
648:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
606:
603:
601:
598:
596:
593:
591:
590:cell junction
588:
586:
583:
581:
578:
577:
575:
572:
571:
565:
562:
560:
557:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2481:
2475:
2425:
2421:
2372:
2368:
2336:
2332:
2304:(3): 453–7.
2301:
2297:
2260:
2256:
2220:
2216:
2185:
2181:
2149:
2145:
2114:
2110:
2079:
2075:
2047:(3): 373–9.
2044:
2040:
2013:(1): 171–2.
2010:
2006:
1979:
1975:
1947:(3): 572–9.
1944:
1940:
1903:
1899:
1865:
1861:
1830:(4): 521–4.
1827:
1823:
1789:
1785:
1751:
1747:
1720:
1716:
1677:
1673:
1631:
1627:
1617:
1582:
1578:
1536:
1532:
1522:
1511:. Retrieved
1507:
1468:
1464:
1418:
1414:
1404:
1393:. Retrieved
1389:
1328:
1324:
1314:
1279:
1275:
1246:
1235:. Retrieved
1231:
1208:
1199:
1190:
1181:
1090:
1087:Interactions
1080:
1050:
1038:
1025:co-repressor
1021:co-repressor
1018:
1005:co-repressor
992:
991:
914:
892:NP_001007027
889:
863:
845:NM_001007026
838:
814:
795:
769:
750:
724:
705:
685:
680:
333:
326:
292:124,733,487
279:124,719,507
53:External IDs
1906:(1): 9–13.
1868:(1): 14–8.
1386:"ATN1 gene"
595:nucleoplasm
564:DNA binding
375:right ovary
31:Identifiers
2497:Categories
2464:atrophin-1
1513:2017-02-21
1395:2017-02-21
1237:2017-03-12
1176:, May 2017
1155:, May 2017
1131:References
1055:known as "
993:Atrophin-1
367:left ovary
337:(ortholog)
191:6,942,321
178:6,924,463
74:HomoloGene
917:NP_031907
896:NP_001931
866:NM_007881
841:NM_001940
671:Orthologs
600:cytoplasm
82:GeneCards
2444:10814707
2409:10737800
2355:10332026
2285:12861680
2247:20003277
2007:Genomics
1941:Genomics
1928:27241147
1890:19708585
1852:40759301
1704:16481466
1650:10814707
1609:20003277
1555:10332026
1487:21577324
1437:17150957
1363:11380927
1355:18953689
1346:11131516
1306:10973986
1172:–
1151:–
1093:interact
1077:dementia
1015:Function
965:Wikidata
650:Sources:
170:12p13.31
2377:Bibcode
2320:9949204
2277:9845282
2239:9647693
2204:9535906
2168:9361003
2133:9074930
2098:8965642
2063:8852663
2027:8786114
1998:8723724
1963:8325628
1920:8136840
1882:8136826
1844:7951323
1814:2590882
1806:7842016
1776:5850726
1768:7647802
1739:7485154
1730:1801383
1695:1410805
1601:9647693
1478:3093063
1297:2175251
1174:Ensembl
1153:Ensembl
997:protein
783:UniProt
738:Ensembl
677:Species
656:QuickGO
605:nucleus
312:pattern
38:Aliases
2473:Human
2470:(MeSH)
2442:
2407:
2397:
2353:
2318:
2283:
2275:
2245:
2237:
2202:
2166:
2131:
2096:
2061:
2025:
1996:
1961:
1926:
1918:
1888:
1880:
1850:
1842:
1812:
1804:
1774:
1766:
1737:
1727:
1702:
1692:
1648:
1607:
1599:
1553:
1485:
1475:
1435:
1361:
1353:
1343:
1304:
1294:
1120:, and
1100:BAIAP2
1095:with:
1075:, and
951:search
949:PubMed
816:O35126
797:P54259
693:Entrez
483:BioGPS
70:104725
62:607462
2400:16267
2281:S2CID
2243:S2CID
1924:S2CID
1886:S2CID
1848:S2CID
1810:S2CID
1772:S2CID
1605:S2CID
1359:S2CID
1112:MAGI2
1106:MAGI1
995:is a
726:13498
686:Mouse
681:Human
652:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
2482:ATN1
2476:ATN1
2440:PMID
2405:PMID
2351:PMID
2316:PMID
2273:PMID
2235:PMID
2200:PMID
2164:PMID
2129:PMID
2094:PMID
2059:PMID
2023:PMID
1994:PMID
1959:PMID
1916:PMID
1878:PMID
1840:PMID
1802:PMID
1764:PMID
1735:PMID
1700:PMID
1646:PMID
1597:PMID
1551:PMID
1483:PMID
1433:PMID
1351:PMID
1302:PMID
1124:WWP2
1118:RERE
1001:gene
707:1822
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:ATN1
78:1461
58:OMIM
45:ATN1
22:ATN1
2430:doi
2395:PMC
2385:doi
2341:doi
2306:doi
2265:doi
2225:doi
2190:doi
2186:273
2154:doi
2150:272
2119:doi
2084:doi
2049:doi
2015:doi
1984:doi
1949:doi
1908:doi
1870:doi
1832:doi
1794:doi
1756:doi
1725:PMC
1690:PMC
1682:doi
1636:doi
1587:doi
1541:doi
1473:PMC
1423:doi
1419:282
1341:PMC
1333:doi
1292:PMC
1284:doi
1280:150
449:lip
288:End
187:End
90:OMA
66:MGI
2499::
2438:.
2424:.
2420:.
2403:.
2393:.
2383:.
2373:97
2371:.
2367:.
2349:.
2335:.
2331:.
2314:.
2300:.
2296:.
2279:.
2271:.
2261:96
2259:.
2241:.
2233:.
2221:11
2219:.
2215:.
2198:.
2184:.
2180:.
2162:.
2148:.
2144:.
2127:.
2113:.
2109:.
2092:.
2080:36
2078:.
2074:.
2057:.
2043:.
2039:.
2021:.
2011:32
2009:.
1992:.
1978:.
1974:.
1957:.
1945:16
1943:.
1939:.
1922:.
1914:.
1902:.
1884:.
1876:.
1864:.
1846:.
1838:.
1826:.
1808:.
1800:.
1788:.
1770:.
1762:.
1752:10
1750:.
1733:.
1721:57
1719:.
1715:.
1698:.
1688:.
1678:20
1676:.
1672:.
1644:.
1630:.
1626:.
1603:.
1595:.
1583:11
1581:.
1577:.
1563:^
1549:.
1535:.
1531:.
1506:.
1495:^
1481:.
1467:.
1463:.
1445:^
1431:.
1417:.
1413:.
1388:.
1371:^
1357:.
1349:.
1339:.
1329:66
1327:.
1323:.
1300:.
1290:.
1278:.
1274:.
1260:^
1230:.
1217:^
1207:.
1189:.
1160:^
1139:^
1071:,
1067:,
1031:.
1011:.
654:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2489:.
2446:.
2432::
2426:9
2411:.
2387::
2379::
2357:.
2343::
2337:8
2322:.
2308::
2302:8
2287:.
2267::
2249:.
2227::
2206:.
2192::
2170:.
2156::
2135:.
2121::
2115:7
2100:.
2086::
2065:.
2051::
2045:5
2029:.
2017::
2000:.
1986::
1980:6
1965:.
1951::
1930:.
1910::
1904:6
1892:.
1872::
1866:6
1854:.
1834::
1828:7
1816:.
1796::
1790:8
1778:.
1758::
1741:.
1706:.
1684::
1652:.
1638::
1632:9
1611:.
1589::
1557:.
1543::
1537:8
1516:.
1489:.
1469:4
1439:.
1425::
1398:.
1365:.
1335::
1308:.
1286::
1254:.
1240:.
1211:.
1193:.
1126:.
1114:,
1108:,
1102:,
212:)
109:)
92::
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