308:
285:
182:
207:
1742:, proteins that recognize correct chromosome attachment to spindle microtubules. Loss of Aurora B lowers the concentration of Mad2 and BubR1 at the kinetochores. In particular, Aurora B seems to be responsible for maintaining the localization of Mad2 and BubR1 to the kinetochore following their initial recruitment, which occurs independent of Aurora B. Aurora B may be directly or indirectly involved in the hyper-phosphorylation of BubR1 seen in mitosis in wild-type cells.
1464:. This analysis showed that the association of Aurora B with centromeres is dynamic (Aurora B at the centromere is constantly exchanging with a pool of cytoplasmic Aurora B). The analysis of tagged Aurora B also suggested that it associates with spindle microtubules during anaphase of mitosis and this association significantly limits its mobility. Finally, a portion of the tagged Aurora B localized to the equatorial cell cortex, having been transported to this location by
559:
314:
213:
1705:). In general, phosphorylation destabilizes intermediate filaments. Therefore, it has been proposed that phosphorylation of intermediate filaments at the cleavage furrow destabilizes the filaments in preparation for cytokinesis. In agreement with this hypothesis, mutation of Aurora B target sites in intermediate filament proteins leads to defects in filament deformation and prevents the final stage of cytokinesis.
1598:). Both Aurora B and MCAK localize to the inner centromere during prometaphase. Aurora B has been shown to recruit MCAK to the centromere and directly phosphorylate MCAK on various residues. Phosphorylation of MCAK by Aurora B limits the ability of MCAK to depolymerize microtubules. Importantly, inhibition of MCAK by a number of approaches leads to improper attachment of kinetochores to spindle microtubules.
6905:
1570:
attachments (sister chromatid pairs in which both sister kinetochores are attached to microtubules radiating from the same spindle pole). Intriguingly, expression of a dominant-negative and catalytically inactive form of Aurora B disrupted microtubule attachment to the kinetochore and prevented the
1601:
It has been hypothesized that tension generated by amphitelic attachment (biorientation; the attachment of sister kinetochores to opposite spindle poles) pulls sister kinetochores apart, thus disrupting the interaction of Aurora B at the innermost portion of the centromere with microtubule binding
1582:
Numerous kinetochore targets of Aurora kinases have been determined in organisms ranging from yeast to man. Most notably, CENP-A is a target of Aurora B. The phosphorylation of CENP-A by Aurora B reaches a maximum in prometaphase. In fact, Aurora A targets the same CENP-A phosphorylation site as
1518:
prior to anaphase. In topoisomerase II-depleted cells, Aurora B and INCENP do not transfer to the central spindle in late mitosis. Instead, they remain tightly associated with the centromeres of non-disjoined sister chromatids. Also, cells deficient in topoisomerase II show significantly reduced
1357:
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules
1819:
A novel function for Aurora B kinase has recently been reported in neurons. Following axotomy of cultured neurons, significant upregulation in Aurora B kinase gene expression was observed coinciding with regenerative axonal sprouting. Furthermore, overexpression of Aurora B kinase results in
61:
1626:
egg cell-free extracts, condensin binding and chromosome condensation occur normally even in the absence of Aurora B. Likewise, after treating cells with an Aurora B enzyme inhibitor (Aurora B localization is not affected), the condensin complex localizes normally.
1583:
Aurora B, and CENP-A phosphorylation by Aurora A is thought to precede that by Aurora B. Thus, a model has been proposed in which CENP-A phosphorylation by Aurora A recruits Aurora B to the centromere, the latter maintaining the phosphorylation state of CENP-A in a
1565:
impairs the alignment of chromosomes at the equator of the mitotic spindle. This process of alignment is referred to as chromosome congression. The reason for this defect is a subject of ongoing study. Aurora B inhibition may lead to an increase in the number of
1602:
sites on the fibrous corona of the outermost centromere. Specifically, the tension generated by biorientation pulls MCAK outside of the area of Aurora B localization. Thus, mitosis proceeds upon biorientation and dissociation of Aurora B from its substrates.
1610:
Aurora B is responsible for phosphorylation of histone-H3 on serine 10 during mitosis. This modification is conserved from yeast (where the kinase is known as Ipl1) to human. Notably, histone-H3 phosphorylation by Aurora B seems not to be responsible for
1807:). Counterintuitively, inhibition of Aurora B kinase actually causes the polyploid cells formed to continue dividing however, because these cells have severe chromosomal abnormalities, they eventually stop dividing or undergo
1681:
In various cell types, overexpression of a catalytically inactive Aurora B prevents cytokinesis. Disruption of cytokinesis can also arise from Aurora B mislocalization due to mutation of Aurora B binding partners.
4524:"Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinase"
3172:"Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase"
4768:
5053:
4038:
Tatsuka M, Katayama H, Ota T, et al. (1998). "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells".
4008:
Shindo M, Nakano H, Kuroyanagi H, et al. (1998). "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2".
3219:
Murata-Hori M, Fumoto K, Fukuta Y, Iwasaki T, Kikuchi A, Tatsuka M, et al. (2000). "Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1p-related kinase from rat".
2445:"Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation"
1488:. Each of the four components of the complex is required for the proper localization and function of the other three. INCENP stimulates Aurora B kinase activity. Survivin might do the same.
3793:
Gürtler U, Tontsch-Grunt U, Jarvis M, Zahn SK, Boehmelt G, Quant J, et al. (2010). "Effect of BI 811283, a novel inhibitor of Aurora B kinase, on tumor senescence and apoptosis".
1712:
regulatory light chain at the cleavage furrow. Inhibition of Aurora B activity prevents proper myosin II localization to the cleavage furrow and disrupts spindle midzone organization.
4761:
2785:"Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis"
1530:), a protein that regulates microtubule dynamics. Indirect immunofluorescence showed that Aurora B and EB1 colocalize during anaphase on the central spindle and in the midbody during
1514:
has been implicated in the regulation of Aurora B localization and enzymatic activity. This regulatory role may be directly associated with the role of topoisomerase II in disjoining
1727:
Presence of Aurora B halts metaphase-to-anaphase transition until proper biorientation is achieved. This is demonstrated in Aurora B deficient cells, where inhibition of Aurora B by
4754:
4961:
321:
220:
4060:
Kimura M, Matsuda Y, Yoshioka T, et al. (1999). "Identification and characterization of STK12/Aik2: a human gene related to aurora of
Drosophila and yeast IPL1".
2598:
Wordeman L, Wagenbach M, Maney T (1999). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)".
1499:-H3 variant centromere protein A (CENP-A). CENP-A associates with the centromere and is necessary for assembly of the kinetochore. Phosphorylation of CENP-A at
3256:"The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint"
2551:"The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint"
5509:
4126:
Prigent C, Gill R, Trower M, Sanseau P (2001). "In silico cloning of a new protein kinase, Aik2, related to
Drosophila Aurora using the new tool: EST Blast".
6348:
4812:
1622:
complex does not localize appropriately to the chromosomes. Similarly, in C. elegans, condensin activity is dependent on Aurora B in metaphase. However, in
1534:. Intriguingly, EB1 overexpression enhances Aurora B kinase activity, at least in part because EB1 blocks the dephosphorylation/inactivation of Aurora B by
6457:
5195:
5082:
4736:
3460:"Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2"
1007:
143:
5470:
4097:
Katayama H, Ota T, Morita K, et al. (1999). "Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells".
988:
6443:
5908:
4799:
4781:
3822:"Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation"
6545:
6426:
1792:
Abnormally elevated levels of Aurora B kinase cause unequal chromosomal separation during cell division, resulting in the formation of cells with
4284:
Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates
Histone H3 at serine28 with regard to the mitotic chromosome condensation".
6132:
5001:
6925:
6196:
5171:
2494:"Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis"
1930:
1402:
1912:
6452:
1507:
recruits Aurora B to the centromere. Aurora B, itself, can also phosphorylate CENP-A at the same residue once it is recruited (see below).
2932:"The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis"
2883:"ISWI remodeling complexes in Xenopus egg extracts: Identification as major chromosomal components that are regulated by INCENP-aurora B"
2294:"CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function"
1638:, and perturbs microtubule dynamics in mitosis. Release of this cohesion, which is dependent on Aurora B, is required for progression to
307:
4986:
1385:
screen for kinases that are overexpressed in cancers. In the same year, rat Aurora kinase B was identified in a screen designed to find
6509:
6184:
4715:
4696:
1278:
284:
6624:
5441:
5431:
5116:
1271:
3079:"A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis"
6123:
2736:"Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes"
1948:
6392:
6064:
5426:
5417:
2687:"Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments"
1899:
1878:
1702:
206:
181:
6780:
1895:
4721:
58:
5807:
5304:
5295:
4952:
4898:
4702:
1460:
cells. A more detailed analysis of Aurora B localization has been carried out in mammalian cells by tagging Aurora B with
6895:
1874:
4995:
123:
1491:
Localization of Aurora B to the centromere during prometaphase and metaphase requires phosphorylation of the mammalian
4645:"Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model"
1851:
1751:
1721:
320:
219:
4746:
3599:"The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly"
6019:
5837:
5333:
6765:
1413:. Expression of Aurora B reaches a maximum at the G2-M transition, whereas Aurora B protein is most active during
313:
212:
6881:
6868:
6855:
6842:
6829:
6816:
6803:
6009:
6004:
5999:
5989:
5984:
5979:
5969:
5764:
5539:
5135:
3912:"Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish"
1461:
1382:
6775:
4149:"INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis"
3501:"INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis"
1731:
causes the cell to progress from metaphase to anaphase even when there are misaligned chromosomes in the cell.
114:, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, STK-1, ARK-2
6729:
6672:
6232:
6223:
6174:
4940:
4785:
4689:
1052:
131:
1724:
inhibits progression of mitosis from metaphase to anaphase until all sister chromatid pairs are bioriented.
6677:
6532:
5955:
1671:
1457:
1033:
4428:"Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate"
2989:"The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis"
3411:"Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores"
1667:
1643:
1618:
In
Drosophila cells, Aurora B depletion disrupts chromosome structure and compaction. In these cells, the
1453:
3305:"Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction"
6698:
6617:
5231:
3038:"Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells"
1690:
1535:
195:
6770:
4200:"CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis"
2245:"CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis"
2103:"Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis"
5798:
4482:
4160:
3512:
3128:"Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process"
2943:
2505:
2397:
1576:
1369:
cells, over-expression of these enzymes causes unequal distribution of genetic information, creating
110:
2066:
Adams RR, Carmena M, Earnshaw WC (2001). "Chromosomal passengers and the (aurora) ABCs of mitosis".
1519:
Aurora B kinase activity. Inhibition of Aurora B due to loss of topoisomerase II seems to depend on
6734:
4727:
4708:
3695:
Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, et al. (June 2004).
2386:"EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A"
1615:
condensation. Though Aurora B is enriched at centromeres, it localizes diffusely to all chromatin.
1465:
1229:
1225:
1221:
1211:
1207:
1203:
1199:
1195:
1150:
1146:
1142:
1132:
1128:
1124:
1120:
1116:
6306:
4685:
3820:
Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, et al. (2005).
3458:
Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, et al. (February 2009).
6930:
6667:
6409:
6363:
4309:
4186:
4085:
3996:
3949:
3628:
3538:
2969:
2765:
2623:
2531:
1449:
155:
4471:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1967:"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers"
1254:
1233:
1175:
1154:
4243:"Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases"
3648:"Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle"
3362:"Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension"
2834:"Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian Aurora kinases"
1803:
in cancer cells leads to the formation of cells with severely abnormal numbers of chromosomes (
5669:
5378:
4666:
4631:
4588:
4553:
4510:
4457:
4414:
4379:
4344:
4301:
4272:
4229:
4178:
4135:
4114:
4077:
4048:
4026:
3988:
3941:
3892:
3843:
3775:
3757:
3718:
3677:
3620:
3579:
3530:
3481:
3440:
3391:
3342:
3324:
3285:
3236:
3201:
3149:
3108:
3059:
3018:
2961:
2912:
2863:
2814:
2757:
2716:
2667:
2615:
2580:
2523:
2474:
2425:
2366:
2315:
2274:
2222:
2181:
2132:
2083:
2048:
1996:
1584:
1515:
103:
51:
6713:
6708:
6682:
6610:
6262:
5504:
5494:
5489:
5407:
5398:
5328:
5319:
5265:
5256:
4913:
4656:
4621:
4613:
4578:
4543:
4535:
4500:
4490:
4447:
4439:
4404:
4369:
4334:
4293:
4262:
4254:
4219:
4211:
4168:
4106:
4069:
4018:
3980:
3931:
3923:
3882:
3874:
3833:
3802:
3765:
3749:
3738:"Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis"
3708:
3667:
3659:
3646:
Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, et al. (July 2004).
3610:
3569:
3520:
3471:
3430:
3422:
3381:
3373:
3332:
3316:
3275:
3267:
3228:
3191:
3183:
3139:
3098:
3090:
3049:
3008:
3000:
2951:
2902:
2894:
2853:
2845:
2804:
2796:
2747:
2706:
2698:
2657:
2607:
2570:
2562:
2513:
2464:
2456:
2415:
2405:
2356:
2346:
2305:
2264:
2256:
2212:
2171:
2163:
2122:
2114:
2075:
2038:
2030:
1986:
1978:
1558:
1511:
400:
331:
275:
230:
2644:
Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, et al. (2004).
558:
151:
6760:
6744:
6657:
6088:
5159:
5154:
5149:
3232:
1839:
1834:
1686:
1504:
1441:
1338:
375:
4602:"Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis"
2152:"Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis"
4486:
4164:
3936:
3911:
3806:
3516:
3409:
Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, et al. (2003).
3360:
Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, et al. (2003).
3036:
Sonoda E, Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, et al. (2001).
2947:
2509:
2401:
2333:
Coelho PA, Queiroz-Machado J, Carmo AM, Moutinho-Pereira S, Maiato H, Sunkel CE (2008).
1650:, the proper centromeric localization of a number of Aurora B binding partners requires
6909:
6798:
6739:
4224:
4199:
3887:
3863:"Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro"
3862:
3770:
3737:
3672:
3647:
3435:
3410:
3337:
3304:
3280:
3255:
3103:
3078:
3013:
2988:
2809:
2784:
2575:
2550:
2469:
2444:
2420:
2385:
2361:
2334:
2292:
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, et al. (2003).
2269:
2244:
2043:
2018:
1991:
1966:
1405:
Aurora kinase B (in green) localizes in a cell cycle dependent manner. (DNA is in blue)
4626:
4601:
4583:
4566:
4548:
4523:
4505:
4470:
4452:
4427:
4358:"Aurora-B associated protein phosphatases as negative regulators of kinase activation"
4267:
4242:
4173:
4148:
4110:
3971:
Nigg EA (2001). "Mitotic kinases as regulators of cell division and its checkpoints".
3525:
3500:
3386:
3361:
3196:
3171:
3054:
3037:
2956:
2931:
2858:
2833:
2752:
2735:
2711:
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2662:
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2518:
2493:
2310:
2293:
2176:
2151:
2127:
2102:
2079:
1401:
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6703:
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5212:
5144:
4740:
4297:
4000:
3878:
2907:
2882:
1829:
1675:
1647:
1547:
1420:
Aurora B is a chromosomal passenger protein. Specifically, Aurora B localizes to the
1390:
587:
4313:
4089:
3910:
Gwee SS, Radford RA, Chow S, Syal MD, Morsch M, Formella I, et al. (Dec 2017).
3632:
2769:
2627:
2535:
6652:
6083:
4908:
4323:"Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins"
3953:
3170:
Kawajiri A, Yasui Y, Goto H, Tatsuka M, Takahashi M, Nagata K, et al. (2003).
2973:
1551:
1433:
393:
172:
135:
4393:"Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells"
4258:
4190:
3558:"Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells"
3542:
3476:
3459:
2849:
2201:"Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells"
2351:
159:
6876:
6811:
6647:
6289:
5921:
5861:
5744:
5664:
5388:
3861:
Ng JM, Chen MJ, Leung JY, Peng ZF, Manikandan J, Qi RZ, et al. (Apr 2012).
3597:
Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (July 2004).
3556:
Chen J, Jin S, Tahir SK, Zhang H, Liu X, Sarthy AV, et al. (January 2003).
1935:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1917:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1663:
1631:
1588:
1531:
1492:
1421:
1359:
1346:
6904:
4661:
4644:
4567:"Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis"
3615:
3598:
3254:
Hauf S, Cole RW, Laterra S, Zimmer C, Schnapp G, Walter R, et al. (2003).
3126:
Goto H, Yasui Y, Kawajiri A, Nigg EA, Terada Y, Tatsuka M, et al. (2003).
2549:
Hauf S, Cole RW, Laterra S, Zimmer C, Schnapp G, Walter R, et al. (2003).
1982:
1587:
loop. Mutation of this phosphorylation site in CENP-A also leads to defects in
476:
17:
6377:
4851:
3927:
2335:"Dual role of topoisomerase II in centromere resolution and aurora B activity"
1820:
accelerated axonal outgrowth of spinal motor neurons in developing zebrafish.
1808:
1793:
1728:
1639:
1562:
1429:
1410:
1370:
1342:
292:
189:
139:
3761:
3328:
2034:
1965:
Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, et al. (1998).
6850:
6824:
5338:
4617:
4539:
3187:
2832:
Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, et al. (2002).
2702:
2410:
2167:
1804:
1709:
1619:
1612:
1437:
1366:
952:
536:
414:
359:
346:
258:
245:
147:
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4635:
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4514:
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4418:
4409:
4392:
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4357:
4348:
4339:
4322:
4305:
4276:
4233:
4182:
4139:
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3945:
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3847:
3779:
3753:
3722:
3713:
3696:
3681:
3624:
3583:
3574:
3557:
3534:
3485:
3444:
3395:
3377:
3346:
3289:
3240:
3205:
3153:
3144:
3127:
3063:
3022:
2965:
2916:
2898:
2867:
2818:
2761:
2734:
Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, et al. (2000).
2720:
2671:
2619:
2611:
2584:
2527:
2478:
2429:
2370:
2319:
2278:
2226:
2217:
2200:
2185:
2136:
2118:
2087:
4215:
4118:
4081:
4052:
4030:
3663:
3426:
3320:
3303:
Santaguida S, Vernieri C, Villa F, Ciliberto A, Musacchio A (2011-04-20).
3271:
3112:
3094:
3004:
2800:
2566:
2460:
2260:
2052:
2000:
1318:
1313:
5694:
5589:
5584:
5579:
4443:
3838:
3821:
1800:
1763:
1694:
1567:
1481:
1477:
1445:
1425:
1302:
1097:
1078:
2199:
Chen J, Jin S, Tahir SK, Zhang H, Liu X, Sarthy AV, et al. (2003).
2019:"AIM-1: A mammalian midbody-associated protein required for cytokinesis"
1546:
Studies in several organisms indicate that Aurora B oversees chromosome
6353:
6331:
6326:
6316:
6311:
6113:
6108:
6103:
6098:
6093:
6078:
6073:
5724:
5689:
4928:
4923:
4918:
1651:
1635:
1623:
1496:
1414:
1409:
The expression and activity of Aurora B are regulated according to the
1386:
1334:
1064:
1019:
4073:
80:
6863:
6633:
6583:
6578:
6573:
6568:
6563:
6558:
6553:
6504:
6499:
6494:
6489:
6484:
6467:
6462:
6336:
6321:
6272:
6267:
6252:
6247:
6242:
6237:
6211:
6206:
6201:
6189:
6167:
6162:
6054:
6029:
5704:
5529:
5524:
5519:
5514:
5499:
5343:
5280:
5275:
5270:
5246:
5072:
5067:
5041:
5036:
5031:
5021:
5016:
5006:
4846:
4777:
3984:
1846:
1698:
1572:
1527:
1500:
1485:
1286:
974:
1594:
Aurora B also interacts with mitotic centromere-associated kinesin (
1630:
Aurora B localizes to the paired arms of homologous chromosomes in
6837:
6479:
6472:
6382:
6279:
6179:
6157:
6152:
6147:
6142:
6137:
6049:
6044:
6039:
6034:
6024:
5994:
5974:
5851:
5846:
5827:
5822:
5812:
5788:
5783:
5778:
5754:
5749:
5739:
5734:
5729:
5719:
5699:
5684:
5679:
5674:
5654:
5649:
5639:
5634:
5629:
5624:
5619:
5609:
5604:
5599:
5594:
5574:
5569:
5564:
5559:
5554:
5549:
5534:
5484:
5479:
5373:
5368:
5363:
5358:
5353:
5348:
5309:
5241:
5236:
5185:
5180:
5106:
5101:
5096:
5062:
5054:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
4856:
4841:
4836:
4831:
4826:
4821:
2017:
Terada Y, Tatsuka M, Suzuki F, Yasuda Y, Fujita S, Otsu M (1998).
1780:
1774:
1769:
1758:
1739:
1595:
1550:
by ensuring that appropriate connections are made between spindle
1520:
1400:
937:
933:
6372:
6299:
6294:
6284:
6257:
6014:
5964:
5945:
5940:
5935:
5930:
5885:
5880:
5875:
5870:
5817:
5773:
5714:
5709:
5659:
5644:
5614:
5544:
5460:
5455:
5450:
5383:
5285:
5226:
5221:
5125:
5091:
4976:
4971:
4966:
4935:
4903:
4891:
4886:
4881:
4871:
4866:
3499:
Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (June 2001).
1735:
127:
6606:
6530:
5906:
4797:
4750:
1358:
called K-fibers, and Aurora kinase A (MIM 603072) localizes to
567:
6341:
4876:
4861:
2384:
Sun L, Gao J, Dong X, Liu M, Li D, Shi X, et al. (2008).
2987:
Rogers E, Bishop JD, Waddle JA, Schumacher JM, Lin R (2002).
2930:
Kaitna S, Pasierbek P, Jantsch M, Loidl J, Glotzer M (2002).
3736:
Chen BB, Glasser JR, Coon TA, Mallampalli RK (August 2013).
4469:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
4147:
Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (2001).
2685:
Kline-Smith SL, Khodjakov A, Hergert P, Walczak CE (2004).
2492:
Kallio MJ, McCleland ML, Stukenberg PT, Gorbsky GJ (2002).
1685:
Aurora B targets a number of proteins that localize to the
6602:
1526:
Aurora B has been shown to bind to end-binding protein 1 (
803:
positive regulation of telomere maintenance via telomerase
808:
negative regulation of transcription by RNA polymerase II
4565:
Minoshima Y, Kawashima T, Hirose K, et al. (2003).
3077:
MacKay AM, Ainsztein AM, Eckley DM, Earnshaw WC (1998).
383:
4426:
Morrison C, Henzing AJ, Jensen ON, et al. (2002).
1606:
Role in chromosome condensation and chromosome cohesion
1381:
In 1998, Aurora kinase B was identified in humans by a
893:
regulation of signal transduction by p53 class mediator
2881:
MacCallum DE, Losada A, Kobayashi R, Hirano T (2002).
863:
anaphase-promoting complex-dependent catabolic process
6893:
548:
4321:
Gigoux V, L'Hoste S, Raynaud F, et al. (2002).
1448:. This localization has been determined by indirect
6789:
6753:
6722:
6691:
6640:
6544:
6442:
6425:
6408:
6391:
6362:
6222:
6122:
6063:
5954:
5920:
5860:
5836:
5797:
5763:
5469:
5440:
5416:
5397:
5318:
5294:
5255:
5211:
5194:
5170:
5134:
5115:
5081:
5052:
4985:
4951:
4811:
4356:Sugiyama K, Sugiura K, Hara T, et al. (2002).
2646:"Aurora B regulates MCAK at the mitotic centromere"
2443:Adams RR, Maiato H, Earnshaw WC, Carmena M (2001).
1247:
1194:
1168:
1115:
1891:
1889:
1887:
1870:
1868:
1866:
4522:Kawajiri A, Yasui Y, Goto H, et al. (2003).
4241:Crosio C, Fimia GM, Loury R, et al. (2002).
878:attachment of spindle microtubules to kinetochore
636:protein serine/threonine/tyrosine kinase activity
330:
229:
3697:"Aurora B -TACC1 protein complex in cytokinesis"
1734:Aurora B may be involved in the localization of
2390:Proceedings of the National Academy of Sciences
1796:, which are both a cause and driver of cancer.
853:negative regulation of B cell apoptotic process
1896:GRCm38: Ensembl release 89: ENSMUSG00000020897
1815:Role in axonal outgrowth and axon regeneration
1476:Aurora B complexes with three other proteins,
6618:
4813:Non-specific serine/threonine protein kinases
4762:
4391:Chen J, Jin S, Tahir SK, et al. (2003).
923:ubiquitin-dependent protein catabolic process
913:mitotic spindle assembly checkpoint signaling
8:
4643:Tien AC, Lin MH, Su LJ, et al. (2004).
4198:Zeitlin SG, Shelby RD, Sullivan KF (2002).
3165:
3163:
2243:Zeitlin SG, Shelby RD, Sullivan KF (2001).
1875:GRCh38: Ensembl release 89: ENSG00000178999
6625:
6611:
6603:
6541:
6527:
5917:
5903:
5196:Goodpasture-antigen-binding protein kinase
4808:
4794:
4769:
4755:
4747:
4737:United States National Library of Medicine
3867:Journal of Cellular and Molecular Medicine
2639:
2637:
2238:
2236:
2101:Murata-Hori M, Tatsuka M, Wang YL (2002).
2012:
2010:
1960:
1958:
1191:
1112:
948:
843:positive regulation of telomerase activity
583:
371:
270:
167:
69:
5909:Serine/threonine-specific protein kinases
5083:(isocitrate dehydrogenase (NADP+)) kinase
4800:Serine/threonine-specific protein kinases
4782:Serine/threonine-specific protein kinases
4688:at the U.S. National Library of Medicine
4660:
4625:
4582:
4547:
4504:
4494:
4451:
4408:
4373:
4338:
4266:
4223:
4172:
3935:
3886:
3837:
3769:
3712:
3671:
3614:
3573:
3524:
3475:
3434:
3385:
3336:
3279:
3195:
3143:
3102:
3053:
3012:
2955:
2906:
2857:
2808:
2751:
2710:
2661:
2574:
2517:
2468:
2419:
2409:
2360:
2350:
2309:
2268:
2216:
2175:
2126:
2042:
1990:
523:fetal liver hematopoietic progenitor cell
6444:Receptor protein serine/threonine kinase
4735:This article incorporates text from the
1337:that functions in the attachment of the
903:mitotic cytokinesis checkpoint signaling
742:condensed chromosome, centromeric region
646:protein serine/threonine kinase activity
6900:
6427:Low-density-lipoprotein receptor kinase
1862:
1716:Role in the spindle assembly checkpoint
1701:, and glial fibrillary acidic protein (
1397:Expression and subcellular localization
773:positive regulation of telomere capping
1662:The Aurora B complex is necessary for
813:negative regulation of protein binding
29:
5172:Fas-activated serine/threonine kinase
3233:10.1093/oxfordjournals.jbchem.a022840
335:
296:
291:
234:
193:
188:
7:
6453:Bone morphogenetic protein receptors
3916:Cellular and Molecular Life Sciences
1949:"Entrez Gene: AURKB aurora kinase B"
823:regulation of chromosome segregation
4987:Dephospho-(reductase kinase) kinase
4600:Honda R, Körner R, Nigg EA (2004).
3807:10.1200/jco.2010.28.15_suppl.e13632
2150:Honda R, Körner R, Nigg EA (2003).
1557:Inhibition of Aurora B function by
883:protein localization to kinetochore
5442:G-protein coupled receptor kinases
1750:Aurora B kinase has been shown to
1393:proliferation when overexpressed.
1244:
1165:
1088:
1069:
1043:
1024:
998:
979:
858:negative regulation of cytokinesis
818:positive regulation of cytokinesis
553:
471:
409:
388:
25:
5432:Beta adrenergic receptor kinase-2
5117:(tyrosine 3-monooxygenase) kinase
1799:Inhibition of Aurora B kinase by
6903:
6124:Mitogen-activated protein kinase
4298:10.1046/j.1356-9597.2001.00498.x
3879:10.1111/j.1582-4934.2011.01361.x
1542:Role in chromosome biorientation
783:mitotic spindle midzone assembly
557:
319:
312:
306:
283:
218:
211:
205:
180:
6510:Anti-Müllerian hormone receptor
6393:(acetyl-CoA carboxylase) kinase
6065:(RNA-polymerase)-subunit kinase
5427:Beta adrenergic receptor kinase
5418:Beta adrenergic receptor kinase
3132:Journal of Biological Chemistry
2205:Journal of Biological Chemistry
1794:abnormal numbers of chromosomes
6133:Extracellular signal-regulated
2838:Molecular and Cellular Biology
1561:or microinjection of blocking
722:chromosome, centromeric region
616:histone serine kinase activity
568:More reference expression data
537:More reference expression data
1:
6197:P38 mitogen-activated protein
5296:cGMP-dependent protein kinase
5257:cAMP-dependent protein kinase
4953:Pyruvate dehydrogenase kinase
4899:Ataxia telangiectasia mutated
4584:10.1016/S1534-5807(03)00089-3
4259:10.1128/MCB.22.3.874-885.2002
4174:10.1016/S0960-9822(01)00238-X
4111:10.1016/S0378-1119(98)00522-8
4011:Biochem. Biophys. Res. Commun
3526:10.1016/S0960-9822(01)00238-X
3477:10.1158/0008-5472.CAN-08-2134
3176:Molecular Biology of the Cell
3055:10.1016/s1534-5807(01)00088-0
2957:10.1016/s0960-9822(02)00820-5
2887:Molecular Biology of the Cell
2850:10.1128/mcb.22.3.874-885.2002
2753:10.1016/s0092-8674(00)00034-9
2691:Molecular Biology of the Cell
2663:10.1016/s1534-5807(04)00025-5
2519:10.1016/s0960-9822(02)00887-4
2311:10.1016/s1534-5807(03)00364-2
2156:Molecular Biology of the Cell
2107:Molecular Biology of the Cell
2080:10.1016/s0962-8924(00)01880-8
1708:Aurora B also phosphorylates
1373:cells, a hallmark of cancer.
873:cell population proliferation
304:
203:
6926:Genes on human chromosome 17
4996:AMP-activated protein kinase
4475:Proc. Natl. Acad. Sci. U.S.A
2352:10.1371/journal.pbio.0060207
1579:(CENP-E) with kinetochores.
908:mitotic spindle organization
838:spindle checkpoint signaling
697:chromosome passenger complex
5911:(EC 2.7.11.21-EC 2.7.11.30)
3801:(15 Suppl e13632): e13632.
3415:The Journal of Cell Biology
3260:The Journal of Cell Biology
3083:The Journal of Cell Biology
2993:The Journal of Cell Biology
2789:The Journal of Cell Biology
2555:The Journal of Cell Biology
2449:The Journal of Cell Biology
2249:The Journal of Cell Biology
1852:Spindle assembly checkpoint
1722:spindle assembly checkpoint
848:protein autophosphorylation
449:stromal cell of endometrium
6947:
5838:Elongation factor 2 kinase
4802:(EC 2.7.11.1-EC 2.7.11.20)
4726:gene details page in the
4707:gene details page in the
4662:10.1074/mcp.M300072-MCP200
3826:J. Clin. Endocrinol. Metab
3616:10.1016/j.cell.2004.06.026
2783:Giet R, Glover DM (2001).
2600:Cell Biology International
441:mucosa of transverse colon
6781:Michaelis–Menten kinetics
6540:
6526:
6233:MAP kinase kinase kinases
5916:
5902:
5765:Myosin light-chain kinase
5471:Ca2+/calmodulin-dependent
5136:Myosin-heavy-chain kinase
4807:
4793:
4128:In Silico Biol. (Gedrukt)
3928:10.1007/s00018-018-2780-5
1931:"Mouse PubMed Reference:"
1913:"Human PubMed Reference:"
1689:, including the type-III
1462:green fluorescent protein
1383:polymerase chain reaction
1317:
1312:
1308:
1301:
1285:
1266:
1251:
1218:
1187:
1172:
1139:
1108:
1095:
1091:
1076:
1072:
1063:
1050:
1046:
1031:
1027:
1018:
1005:
1001:
986:
982:
973:
958:
951:
947:
931:
918:regulation of cytokinesis
768:cleavage furrow formation
586:
582:
565:
556:
547:
534:
483:
474:
421:
412:
382:
374:
370:
353:
340:
303:
282:
273:
269:
252:
239:
202:
179:
170:
166:
121:
118:
108:
101:
96:
77:
72:
55:
50:
45:
41:
37:
32:
6673:Diffusion-limited enzyme
6533:Dual-specificity kinases
4690:Medical Subject Headings
3973:Nat. Rev. Mol. Cell Biol
3742:Cell Death & Disease
1983:10.1093/emboj/17.11.3052
1646:. In mitotic vertebrate
1362:(Lampson et al., 2004).
1279:Chr 11: 68.94 – 68.94 Mb
5956:Cyclin-dependent kinase
4618:10.1091/mbc.E02-11-0769
4540:10.1091/mbc.E02-09-0612
3221:Journal of Biochemistry
3188:10.1091/mbc.E02-09-0612
2703:10.1091/mbc.E03-08-0581
2411:10.1073/pnas.0710018105
2168:10.1091/mbc.E02-11-0769
833:protein phosphorylation
793:cellular response to UV
747:mitotic spindle midzone
682:spindle pole centrosome
611:protein kinase activity
4496:10.1073/pnas.242603899
4410:10.1074/jbc.M211119200
4375:10.1038/sj.onc.1205432
4340:10.1074/jbc.C200121200
4023:10.1006/bbrc.1998.8250
3754:10.1038/cddis.2013.271
3714:10.1038/sj.onc.1207593
3575:10.1074/jbc.M211119200
3145:10.1074/jbc.M210892200
2899:10.1091/mbc.01-09-0441
2612:10.1006/cbir.1999.0359
2218:10.1074/jbc.M211119200
2119:10.1091/mbc.01-09-0467
2068:Trends in Cell Biology
2035:10.1093/emboj/17.3.667
1644:homologous chromosomes
1523:activity (see below).
1472:Regulation of Aurora B
1406:
337:11 B3|11 42.32 cM
6766:Eadie–Hofstee diagram
6699:Allosteric regulation
4649:Mol. Cell. Proteomics
4216:10.1083/jcb.200108125
4062:Cytogenet. Cell Genet
3664:10.1083/jcb.200404001
3427:10.1083/jcb.200208091
3321:10.1038/emboj.2011.70
3272:10.1083/jcb.200208092
3095:10.1083/jcb.140.5.991
3005:10.1083/jcb.200110045
2801:10.1083/jcb.152.4.669
2567:10.1083/jcb.200208092
2461:10.1083/jcb.153.4.865
2261:10.1083/jcb.200108125
1691:intermediate filament
1536:protein phosphatase 2
1404:
1272:Chr 17: 8.2 – 8.21 Mb
298:Chromosome 11 (mouse)
196:Chromosome 17 (human)
6776:Lineweaver–Burk plot
5799:Phosphorylase kinase
4720:genome location and
4701:genome location and
4686:AURKB+protein,+human
3839:10.1210/jc.2004-1518
3378:10.1093/emboj/cdg307
1577:centromere protein E
888:spindle organization
788:histone modification
601:transferase activity
73:List of PDB id codes
46:Available structures
4728:UCSC Genome Browser
4709:UCSC Genome Browser
4487:2002PNAS...9916899M
4165:2001CBio...11..886W
3517:2001CBio...11..886W
2948:2002CBio...12..798K
2510:2002CBio...12..900K
2402:2008PNAS..105.7153S
1658:Role in cytokinesis
1642:and segregation of
1466:astral microtubules
707:spindle microtubule
429:ganglionic eminence
6735:Enzyme superfamily
6668:Enzyme promiscuity
6410:Tropomyosin kinase
6364:Tau-protein kinase
4739:, which is in the
4444:10.1093/nar/gkf665
3042:Developmental Cell
2650:Developmental Cell
2298:Developmental Cell
1554:and kinetochores.
1450:immunofluorescence
1440:, and the central
1407:
1053:ENSMUSG00000020897
898:mitotic cell cycle
756:Biological process
660:Cellular component
606:nucleotide binding
594:Molecular function
6891:
6890:
6600:
6599:
6596:
6595:
6592:
6591:
6522:
6521:
6518:
6517:
5898:
5897:
5894:
5893:
5379:Protein kinase N1
5334:Protein kinase Cζ
4481:(26): 16899–903.
4432:Nucleic Acids Res
4074:10.1159/000015089
3922:(23): 4269–4285.
1585:positive feedback
1516:sister chromatids
1328:
1327:
1324:
1323:
1297:
1296:
1262:
1261:
1241:
1240:
1183:
1182:
1162:
1161:
1104:
1103:
1085:
1084:
1059:
1058:
1040:
1039:
1014:
1013:
995:
994:
943:
942:
621:metal ion binding
578:
577:
574:
573:
543:
542:
530:
529:
468:
467:
366:
365:
265:
264:
160:AURKB - orthologs
92:
91:
88:
87:
56:Ortholog search:
16:(Redirected from
6938:
6908:
6907:
6899:
6771:Hanes–Woolf plot
6714:Enzyme activator
6709:Enzyme inhibitor
6683:Enzyme catalysis
6627:
6620:
6613:
6604:
6542:
6528:
6175:C-Jun N-terminal
5918:
5904:
5408:Rhodopsin kinase
5399:Rhodopsin kinase
5329:Protein kinase C
5320:Protein kinase C
5305:Protein kinase G
5266:Protein kinase A
4877:Protein kinase B
4809:
4795:
4771:
4764:
4757:
4748:
4674:
4664:
4639:
4629:
4596:
4586:
4561:
4551:
4518:
4508:
4498:
4465:
4455:
4422:
4412:
4387:
4377:
4352:
4342:
4317:
4280:
4270:
4237:
4227:
4194:
4176:
4143:
4122:
4093:
4056:
4034:
4004:
3985:10.1038/35048096
3958:
3957:
3939:
3907:
3901:
3900:
3890:
3858:
3852:
3851:
3841:
3817:
3811:
3810:
3790:
3784:
3783:
3773:
3733:
3727:
3726:
3716:
3692:
3686:
3685:
3675:
3643:
3637:
3636:
3618:
3594:
3588:
3587:
3577:
3553:
3547:
3546:
3528:
3496:
3490:
3489:
3479:
3455:
3449:
3448:
3438:
3406:
3400:
3399:
3389:
3366:The EMBO Journal
3357:
3351:
3350:
3340:
3315:(8): 1508–1519.
3309:The EMBO Journal
3300:
3294:
3293:
3283:
3251:
3245:
3244:
3216:
3210:
3209:
3199:
3167:
3158:
3157:
3147:
3123:
3117:
3116:
3106:
3074:
3068:
3067:
3057:
3033:
3027:
3026:
3016:
2984:
2978:
2977:
2959:
2927:
2921:
2920:
2910:
2878:
2872:
2871:
2861:
2829:
2823:
2822:
2812:
2780:
2774:
2773:
2755:
2731:
2725:
2724:
2714:
2682:
2676:
2675:
2665:
2641:
2632:
2631:
2595:
2589:
2588:
2578:
2546:
2540:
2539:
2521:
2489:
2483:
2482:
2472:
2440:
2434:
2433:
2423:
2413:
2381:
2375:
2374:
2364:
2354:
2330:
2324:
2323:
2313:
2289:
2283:
2282:
2272:
2240:
2231:
2230:
2220:
2196:
2190:
2189:
2179:
2147:
2141:
2140:
2130:
2098:
2092:
2091:
2063:
2057:
2056:
2046:
2023:The EMBO Journal
2014:
2005:
2004:
1994:
1971:The EMBO Journal
1962:
1953:
1952:
1945:
1939:
1938:
1927:
1921:
1920:
1909:
1903:
1893:
1882:
1872:
1666:in vertebrates,
1559:RNA interference
1512:topoisomerase II
1310:
1309:
1281:
1274:
1257:
1245:
1236:
1192:
1188:RefSeq (protein)
1178:
1166:
1157:
1113:
1089:
1070:
1044:
1025:
999:
980:
949:
584:
570:
561:
554:
539:
507:ventricular zone
491:genital tubercle
479:
477:Top expressed in
472:
425:ventricular zone
417:
415:Top expressed in
410:
389:
372:
362:
349:
338:
323:
316:
310:
299:
287:
271:
261:
248:
237:
222:
215:
209:
198:
184:
168:
162:
113:
106:
83:
70:
64:
43:
42:
30:
21:
6946:
6945:
6941:
6940:
6939:
6937:
6936:
6935:
6916:
6915:
6914:
6902:
6894:
6892:
6887:
6799:Oxidoreductases
6785:
6761:Enzyme kinetics
6749:
6745:List of enzymes
6718:
6687:
6658:Catalytic triad
6636:
6631:
6601:
6588:
6536:
6514:
6438:
6421:
6404:
6387:
6358:
6218:
6118:
6089:P70-S6 Kinase 1
6059:
5950:
5912:
5890:
5856:
5832:
5793:
5759:
5465:
5436:
5412:
5393:
5314:
5290:
5251:
5207:
5190:
5166:
5160:Aurora C kinase
5155:Aurora B kinase
5150:Aurora A kinase
5130:
5111:
5077:
5048:
4981:
4947:
4803:
4789:
4775:
4682:
4677:
4642:
4606:Mol. Biol. Cell
4599:
4564:
4534:(4): 1489–500.
4528:Mol. Biol. Cell
4521:
4468:
4438:(23): 5318–27.
4425:
4390:
4368:(20): 3103–11.
4355:
4333:(26): 23742–6.
4320:
4283:
4247:Mol. Cell. Biol
4240:
4197:
4146:
4125:
4096:
4068:(3–4): 147–52.
4059:
4037:
4007:
3970:
3966:
3964:Further reading
3961:
3909:
3908:
3904:
3860:
3859:
3855:
3819:
3818:
3814:
3792:
3791:
3787:
3735:
3734:
3730:
3707:(26): 4516–22.
3694:
3693:
3689:
3645:
3644:
3640:
3596:
3595:
3591:
3555:
3554:
3550:
3505:Current Biology
3498:
3497:
3493:
3464:Cancer Research
3457:
3456:
3452:
3408:
3407:
3403:
3372:(12): 2934–47.
3359:
3358:
3354:
3302:
3301:
3297:
3253:
3252:
3248:
3218:
3217:
3213:
3182:(4): 1489–500.
3169:
3168:
3161:
3138:(10): 8526–30.
3125:
3124:
3120:
3089:(5): 991–1002.
3076:
3075:
3071:
3035:
3034:
3030:
2986:
2985:
2981:
2942:(10): 798–812.
2936:Current Biology
2929:
2928:
2924:
2880:
2879:
2875:
2831:
2830:
2826:
2782:
2781:
2777:
2733:
2732:
2728:
2684:
2683:
2679:
2643:
2642:
2635:
2597:
2596:
2592:
2548:
2547:
2543:
2498:Current Biology
2491:
2490:
2486:
2442:
2441:
2437:
2383:
2382:
2378:
2332:
2331:
2327:
2291:
2290:
2286:
2242:
2241:
2234:
2198:
2197:
2193:
2149:
2148:
2144:
2113:(4): 1099–108.
2100:
2099:
2095:
2065:
2064:
2060:
2016:
2015:
2008:
1977:(11): 3052–65.
1964:
1963:
1956:
1947:
1946:
1942:
1929:
1928:
1924:
1911:
1910:
1906:
1894:
1885:
1873:
1864:
1860:
1840:Aurora C kinase
1835:Aurora A kinase
1826:
1817:
1790:
1748:
1718:
1687:cleavage furrow
1660:
1608:
1571:association of
1544:
1505:Aurora A kinase
1474:
1442:mitotic spindle
1399:
1379:
1355:
1339:mitotic spindle
1331:Aurora kinase B
1319:View/Edit Mouse
1314:View/Edit Human
1277:
1270:
1267:Location (UCSC)
1253:
1232:
1228:
1224:
1220:
1214:
1210:
1206:
1202:
1198:
1174:
1153:
1149:
1145:
1141:
1135:
1131:
1127:
1123:
1119:
1034:ENSG00000178999
927:
778:phosphorylation
751:
712:spindle midzone
655:
631:protein binding
626:kinase activity
566:
535:
526:
521:
517:
513:
509:
505:
501:
497:
493:
489:
475:
464:
459:
455:
451:
447:
443:
439:
435:
431:
427:
413:
357:
344:
336:
326:
325:
324:
317:
297:
274:Gene location (
256:
243:
235:
225:
224:
223:
216:
194:
171:Gene location (
122:
109:
102:
79:
57:
28:
23:
22:
18:Aurora B kinase
15:
12:
11:
5:
6944:
6942:
6934:
6933:
6928:
6918:
6917:
6913:
6912:
6889:
6888:
6886:
6885:
6872:
6859:
6846:
6833:
6820:
6807:
6793:
6791:
6787:
6786:
6784:
6783:
6778:
6773:
6768:
6763:
6757:
6755:
6751:
6750:
6748:
6747:
6742:
6737:
6732:
6726:
6724:
6723:Classification
6720:
6719:
6717:
6716:
6711:
6706:
6701:
6695:
6693:
6689:
6688:
6686:
6685:
6680:
6675:
6670:
6665:
6660:
6655:
6650:
6644:
6642:
6638:
6637:
6632:
6630:
6629:
6622:
6615:
6607:
6598:
6597:
6594:
6593:
6590:
6589:
6587:
6586:
6581:
6576:
6571:
6566:
6561:
6556:
6550:
6548:
6538:
6537:
6531:
6524:
6523:
6520:
6519:
6516:
6515:
6513:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6477:
6476:
6475:
6470:
6465:
6460:
6449:
6447:
6446:(EC 2.7.11.30)
6440:
6439:
6437:
6436:
6432:
6430:
6429:(EC 2.7.11.29)
6423:
6422:
6420:
6419:
6415:
6413:
6412:(EC 2.7.11.28)
6406:
6405:
6403:
6402:
6398:
6396:
6395:(EC 2.7.11.27)
6389:
6388:
6386:
6385:
6380:
6375:
6369:
6367:
6366:(EC 2.7.11.26)
6360:
6359:
6357:
6356:
6351:
6346:
6345:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6304:
6303:
6302:
6297:
6292:
6287:
6277:
6276:
6275:
6270:
6265:
6260:
6255:
6250:
6245:
6240:
6229:
6227:
6226:(EC 2.7.11.25)
6220:
6219:
6217:
6216:
6215:
6214:
6209:
6204:
6194:
6193:
6192:
6187:
6182:
6172:
6171:
6170:
6165:
6160:
6155:
6150:
6145:
6140:
6129:
6127:
6126:(EC 2.7.11.24)
6120:
6119:
6117:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6070:
6068:
6067:(EC 2.7.11.23)
6061:
6060:
6058:
6057:
6052:
6047:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5967:
5961:
5959:
5958:(EC 2.7.11.22)
5952:
5951:
5949:
5948:
5943:
5938:
5933:
5927:
5925:
5924:(EC 2.7.11.21)
5914:
5913:
5907:
5900:
5899:
5896:
5895:
5892:
5891:
5889:
5888:
5883:
5878:
5873:
5867:
5865:
5864:(EC 2.7.11.21)
5858:
5857:
5855:
5854:
5849:
5843:
5841:
5840:(EC 2.7.11.20)
5834:
5833:
5831:
5830:
5825:
5820:
5815:
5810:
5804:
5802:
5801:(EC 2.7.11.19)
5795:
5794:
5792:
5791:
5786:
5781:
5776:
5770:
5768:
5767:(EC 2.7.11.18)
5761:
5760:
5758:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5647:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5492:
5487:
5482:
5476:
5474:
5473:(EC 2.7.11.17)
5467:
5466:
5464:
5463:
5458:
5453:
5447:
5445:
5444:(EC 2.7.11.16)
5438:
5437:
5435:
5434:
5429:
5423:
5421:
5420:(EC 2.7.11.15)
5414:
5413:
5411:
5410:
5404:
5402:
5401:(EC 2.7.11.14)
5395:
5394:
5392:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
5325:
5323:
5322:(EC 2.7.11.13)
5316:
5315:
5313:
5312:
5307:
5301:
5299:
5298:(EC 2.7.11.12)
5292:
5291:
5289:
5288:
5283:
5278:
5273:
5268:
5262:
5260:
5259:(EC 2.7.11.11)
5253:
5252:
5250:
5249:
5244:
5239:
5234:
5229:
5224:
5218:
5216:
5215:(EC 2.7.11.10)
5209:
5208:
5206:
5205:
5201:
5199:
5192:
5191:
5189:
5188:
5183:
5177:
5175:
5168:
5167:
5165:
5164:
5163:
5162:
5157:
5152:
5141:
5139:
5132:
5131:
5129:
5128:
5122:
5120:
5113:
5112:
5110:
5109:
5104:
5099:
5094:
5088:
5086:
5079:
5078:
5076:
5075:
5070:
5065:
5059:
5057:
5050:
5049:
5047:
5046:
5045:
5044:
5039:
5034:
5026:
5025:
5024:
5019:
5011:
5010:
5009:
5004:
4992:
4990:
4983:
4982:
4980:
4979:
4974:
4969:
4964:
4958:
4956:
4949:
4948:
4946:
4945:
4944:
4943:
4933:
4932:
4931:
4926:
4921:
4916:
4906:
4901:
4896:
4895:
4894:
4889:
4884:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4818:
4816:
4805:
4804:
4798:
4791:
4790:
4776:
4774:
4773:
4766:
4759:
4751:
4732:
4731:
4712:
4693:
4681:
4680:External links
4678:
4676:
4675:
4640:
4612:(8): 3325–41.
4597:
4562:
4519:
4466:
4423:
4388:
4353:
4318:
4281:
4238:
4210:(7): 1147–57.
4195:
4159:(11): 886–90.
4144:
4123:
4094:
4057:
4047:(21): 4811–6.
4035:
4005:
3967:
3965:
3962:
3960:
3959:
3902:
3873:(4): 789–811.
3853:
3812:
3795:J. Clin. Oncol
3785:
3728:
3687:
3638:
3609:(2): 187–202.
3589:
3548:
3511:(11): 886–90.
3491:
3470:(3): 1125–34.
3450:
3401:
3352:
3295:
3246:
3211:
3159:
3118:
3069:
3028:
2979:
2922:
2873:
2824:
2775:
2726:
2697:(3): 1146–59.
2677:
2633:
2590:
2541:
2484:
2435:
2396:(20): 7153–8.
2376:
2325:
2284:
2255:(7): 1147–57.
2232:
2191:
2162:(8): 3325–41.
2142:
2093:
2058:
2006:
1954:
1940:
1922:
1904:
1883:
1861:
1859:
1856:
1855:
1854:
1849:
1844:
1843:
1842:
1837:
1825:
1822:
1816:
1813:
1789:
1788:Role in cancer
1786:
1785:
1784:
1778:
1772:
1767:
1761:
1747:
1744:
1717:
1714:
1659:
1656:
1634:of C. elegans
1607:
1604:
1543:
1540:
1510:Additionally,
1473:
1470:
1452:in mammalian,
1398:
1395:
1378:
1375:
1354:
1351:
1326:
1325:
1322:
1321:
1316:
1306:
1305:
1299:
1298:
1295:
1294:
1292:
1290:
1283:
1282:
1275:
1268:
1264:
1263:
1260:
1259:
1249:
1248:
1242:
1239:
1238:
1216:
1215:
1189:
1185:
1184:
1181:
1180:
1170:
1169:
1163:
1160:
1159:
1137:
1136:
1110:
1106:
1105:
1102:
1101:
1093:
1092:
1086:
1083:
1082:
1074:
1073:
1067:
1061:
1060:
1057:
1056:
1048:
1047:
1041:
1038:
1037:
1029:
1028:
1022:
1016:
1015:
1012:
1011:
1003:
1002:
996:
993:
992:
984:
983:
977:
971:
970:
965:
960:
956:
955:
945:
944:
941:
940:
929:
928:
926:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
759:
757:
753:
752:
750:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
663:
661:
657:
656:
654:
653:
651:kinase binding
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
597:
595:
591:
590:
580:
579:
576:
575:
572:
571:
563:
562:
551:
545:
544:
541:
540:
532:
531:
528:
527:
525:
524:
520:
516:
512:
511:abdominal wall
508:
504:
500:
496:
492:
488:
487:tail of embryo
484:
481:
480:
469:
466:
465:
463:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
419:
418:
406:
405:
397:
386:
380:
379:
376:RNA expression
368:
367:
364:
363:
355:
351:
350:
342:
339:
334:
328:
327:
318:
311:
305:
301:
300:
295:
289:
288:
280:
279:
267:
266:
263:
262:
254:
250:
249:
241:
238:
233:
227:
226:
217:
210:
204:
200:
199:
192:
186:
185:
177:
176:
164:
163:
120:
116:
115:
107:
99:
98:
94:
93:
90:
89:
86:
85:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6943:
6932:
6929:
6927:
6924:
6923:
6921:
6911:
6906:
6901:
6897:
6883:
6879:
6878:
6873:
6870:
6866:
6865:
6860:
6857:
6853:
6852:
6847:
6844:
6840:
6839:
6834:
6831:
6827:
6826:
6821:
6818:
6814:
6813:
6808:
6805:
6801:
6800:
6795:
6794:
6792:
6788:
6782:
6779:
6777:
6774:
6772:
6769:
6767:
6764:
6762:
6759:
6758:
6756:
6752:
6746:
6743:
6741:
6740:Enzyme family
6738:
6736:
6733:
6731:
6728:
6727:
6725:
6721:
6715:
6712:
6710:
6707:
6705:
6704:Cooperativity
6702:
6700:
6697:
6696:
6694:
6690:
6684:
6681:
6679:
6676:
6674:
6671:
6669:
6666:
6664:
6663:Oxyanion hole
6661:
6659:
6656:
6654:
6651:
6649:
6646:
6645:
6643:
6639:
6635:
6628:
6623:
6621:
6616:
6614:
6609:
6608:
6605:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6565:
6562:
6560:
6557:
6555:
6552:
6551:
6549:
6547:
6543:
6539:
6534:
6529:
6525:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6478:
6474:
6471:
6469:
6466:
6464:
6461:
6459:
6456:
6455:
6454:
6451:
6450:
6448:
6445:
6441:
6434:
6433:
6431:
6428:
6424:
6417:
6416:
6414:
6411:
6407:
6400:
6399:
6397:
6394:
6390:
6384:
6381:
6379:
6376:
6374:
6371:
6370:
6368:
6365:
6361:
6355:
6352:
6350:
6347:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6310:
6309:
6308:
6305:
6301:
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6282:
6281:
6278:
6274:
6271:
6269:
6266:
6264:
6261:
6259:
6256:
6254:
6251:
6249:
6246:
6244:
6241:
6239:
6236:
6235:
6234:
6231:
6230:
6228:
6225:
6221:
6213:
6210:
6208:
6205:
6203:
6200:
6199:
6198:
6195:
6191:
6188:
6186:
6183:
6181:
6178:
6177:
6176:
6173:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6135:
6134:
6131:
6130:
6128:
6125:
6121:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6071:
6069:
6066:
6062:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5966:
5963:
5962:
5960:
5957:
5953:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5928:
5926:
5923:
5919:
5915:
5910:
5905:
5901:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5868:
5866:
5863:
5859:
5853:
5850:
5848:
5845:
5844:
5842:
5839:
5835:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5805:
5803:
5800:
5796:
5790:
5787:
5785:
5782:
5780:
5777:
5775:
5772:
5771:
5769:
5766:
5762:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5477:
5475:
5472:
5468:
5462:
5459:
5457:
5454:
5452:
5449:
5448:
5446:
5443:
5439:
5433:
5430:
5428:
5425:
5424:
5422:
5419:
5415:
5409:
5406:
5405:
5403:
5400:
5396:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5326:
5324:
5321:
5317:
5311:
5308:
5306:
5303:
5302:
5300:
5297:
5293:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5263:
5261:
5258:
5254:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5219:
5217:
5214:
5210:
5203:
5202:
5200:
5198:(EC 2.7.11.9)
5197:
5193:
5187:
5184:
5182:
5179:
5178:
5176:
5174:(EC 2.7.11.8)
5173:
5169:
5161:
5158:
5156:
5153:
5151:
5148:
5147:
5146:
5145:Aurora kinase
5143:
5142:
5140:
5138:(EC 2.7.11.7)
5137:
5133:
5127:
5124:
5123:
5121:
5119:(EC 2.7.11.6)
5118:
5114:
5108:
5105:
5103:
5100:
5098:
5095:
5093:
5090:
5089:
5087:
5085:(EC 2.7.11.5)
5084:
5080:
5074:
5071:
5069:
5066:
5064:
5061:
5060:
5058:
5056:(EC 2.7.11.4)
5055:
5051:
5043:
5040:
5038:
5035:
5033:
5030:
5029:
5027:
5023:
5020:
5018:
5015:
5014:
5012:
5008:
5005:
5003:
5000:
4999:
4997:
4994:
4993:
4991:
4989:(EC 2.7.11.3)
4988:
4984:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4959:
4957:
4955:(EC 2.7.11.2)
4954:
4950:
4942:
4939:
4938:
4937:
4934:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4911:
4910:
4909:EIF-2 kinases
4907:
4905:
4902:
4900:
4897:
4893:
4890:
4888:
4885:
4883:
4880:
4879:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4819:
4817:
4815:(EC 2.7.11.1)
4814:
4810:
4806:
4801:
4796:
4792:
4787:
4783:
4779:
4772:
4767:
4765:
4760:
4758:
4753:
4752:
4749:
4745:
4744:
4742:
4741:public domain
4738:
4729:
4725:
4724:
4719:
4718:
4713:
4710:
4706:
4705:
4700:
4699:
4694:
4691:
4687:
4684:
4683:
4679:
4672:
4668:
4663:
4658:
4655:(1): 93–104.
4654:
4650:
4646:
4641:
4637:
4633:
4628:
4623:
4619:
4615:
4611:
4607:
4603:
4598:
4594:
4590:
4585:
4580:
4577:(4): 549–60.
4576:
4572:
4568:
4563:
4559:
4555:
4550:
4545:
4541:
4537:
4533:
4529:
4525:
4520:
4516:
4512:
4507:
4502:
4497:
4492:
4488:
4484:
4480:
4476:
4472:
4467:
4463:
4459:
4454:
4449:
4445:
4441:
4437:
4433:
4429:
4424:
4420:
4416:
4411:
4406:
4403:(1): 486–90.
4402:
4398:
4397:J. Biol. Chem
4394:
4389:
4385:
4381:
4376:
4371:
4367:
4363:
4359:
4354:
4350:
4346:
4341:
4336:
4332:
4328:
4327:J. Biol. Chem
4324:
4319:
4315:
4311:
4307:
4303:
4299:
4295:
4291:
4287:
4282:
4278:
4274:
4269:
4264:
4260:
4256:
4253:(3): 874–85.
4252:
4248:
4244:
4239:
4235:
4231:
4226:
4221:
4217:
4213:
4209:
4205:
4201:
4196:
4192:
4188:
4184:
4180:
4175:
4170:
4166:
4162:
4158:
4154:
4150:
4145:
4141:
4137:
4133:
4129:
4124:
4120:
4116:
4112:
4108:
4104:
4100:
4095:
4091:
4087:
4083:
4079:
4075:
4071:
4067:
4063:
4058:
4054:
4050:
4046:
4042:
4036:
4032:
4028:
4024:
4020:
4017:(1): 285–92.
4016:
4012:
4006:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3974:
3969:
3968:
3963:
3955:
3951:
3947:
3943:
3938:
3933:
3929:
3925:
3921:
3917:
3913:
3906:
3903:
3898:
3894:
3889:
3884:
3880:
3876:
3872:
3868:
3864:
3857:
3854:
3849:
3845:
3840:
3835:
3832:(2): 928–35.
3831:
3827:
3823:
3816:
3813:
3808:
3804:
3800:
3796:
3789:
3786:
3781:
3777:
3772:
3767:
3763:
3759:
3755:
3751:
3747:
3743:
3739:
3732:
3729:
3724:
3720:
3715:
3710:
3706:
3702:
3698:
3691:
3688:
3683:
3679:
3674:
3669:
3665:
3661:
3658:(2): 179–91.
3657:
3653:
3649:
3642:
3639:
3634:
3630:
3626:
3622:
3617:
3612:
3608:
3604:
3600:
3593:
3590:
3585:
3581:
3576:
3571:
3568:(1): 486–90.
3567:
3563:
3562:J. Biol. Chem
3559:
3552:
3549:
3544:
3540:
3536:
3532:
3527:
3522:
3518:
3514:
3510:
3506:
3502:
3495:
3492:
3487:
3483:
3478:
3473:
3469:
3465:
3461:
3454:
3451:
3446:
3442:
3437:
3432:
3428:
3424:
3421:(2): 267–80.
3420:
3416:
3412:
3405:
3402:
3397:
3393:
3388:
3383:
3379:
3375:
3371:
3367:
3363:
3356:
3353:
3348:
3344:
3339:
3334:
3330:
3326:
3322:
3318:
3314:
3310:
3306:
3299:
3296:
3291:
3287:
3282:
3277:
3273:
3269:
3266:(2): 281–94.
3265:
3261:
3257:
3250:
3247:
3242:
3238:
3234:
3230:
3226:
3222:
3215:
3212:
3207:
3203:
3198:
3193:
3189:
3185:
3181:
3177:
3173:
3166:
3164:
3160:
3155:
3151:
3146:
3141:
3137:
3133:
3129:
3122:
3119:
3114:
3110:
3105:
3100:
3096:
3092:
3088:
3084:
3080:
3073:
3070:
3065:
3061:
3056:
3051:
3048:(6): 759–70.
3047:
3043:
3039:
3032:
3029:
3024:
3020:
3015:
3010:
3006:
3002:
2999:(2): 219–29.
2998:
2994:
2990:
2983:
2980:
2975:
2971:
2967:
2963:
2958:
2953:
2949:
2945:
2941:
2937:
2933:
2926:
2923:
2918:
2914:
2909:
2904:
2900:
2896:
2892:
2888:
2884:
2877:
2874:
2869:
2865:
2860:
2855:
2851:
2847:
2844:(3): 874–85.
2843:
2839:
2835:
2828:
2825:
2820:
2816:
2811:
2806:
2802:
2798:
2795:(4): 669–82.
2794:
2790:
2786:
2779:
2776:
2771:
2767:
2763:
2759:
2754:
2749:
2746:(3): 279–91.
2745:
2741:
2737:
2730:
2727:
2722:
2718:
2713:
2708:
2704:
2700:
2696:
2692:
2688:
2681:
2678:
2673:
2669:
2664:
2659:
2656:(2): 253–68.
2655:
2651:
2647:
2640:
2638:
2634:
2629:
2625:
2621:
2617:
2613:
2609:
2606:(4): 275–86.
2605:
2601:
2594:
2591:
2586:
2582:
2577:
2572:
2568:
2564:
2561:(2): 281–94.
2560:
2556:
2552:
2545:
2542:
2537:
2533:
2529:
2525:
2520:
2515:
2511:
2507:
2504:(11): 900–5.
2503:
2499:
2495:
2488:
2485:
2480:
2476:
2471:
2466:
2462:
2458:
2455:(4): 865–80.
2454:
2450:
2446:
2439:
2436:
2431:
2427:
2422:
2417:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2380:
2377:
2372:
2368:
2363:
2358:
2353:
2348:
2344:
2340:
2336:
2329:
2326:
2321:
2317:
2312:
2307:
2304:(6): 853–64.
2303:
2299:
2295:
2288:
2285:
2280:
2276:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2239:
2237:
2233:
2228:
2224:
2219:
2214:
2211:(1): 486–90.
2210:
2206:
2202:
2195:
2192:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2157:
2153:
2146:
2143:
2138:
2134:
2129:
2124:
2120:
2116:
2112:
2108:
2104:
2097:
2094:
2089:
2085:
2081:
2077:
2073:
2069:
2062:
2059:
2054:
2050:
2045:
2040:
2036:
2032:
2029:(3): 667–76.
2028:
2024:
2020:
2013:
2011:
2007:
2002:
1998:
1993:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1959:
1955:
1950:
1944:
1941:
1936:
1932:
1926:
1923:
1918:
1914:
1908:
1905:
1901:
1897:
1892:
1890:
1888:
1884:
1880:
1876:
1871:
1869:
1867:
1863:
1857:
1853:
1850:
1848:
1845:
1841:
1838:
1836:
1833:
1832:
1831:
1830:Aurora kinase
1828:
1827:
1823:
1821:
1814:
1812:
1810:
1806:
1802:
1797:
1795:
1787:
1782:
1779:
1776:
1773:
1771:
1768:
1765:
1762:
1760:
1757:
1756:
1755:
1753:
1745:
1743:
1741:
1737:
1732:
1730:
1725:
1723:
1715:
1713:
1711:
1706:
1704:
1700:
1696:
1692:
1688:
1683:
1679:
1677:
1676:fission yeast
1673:
1669:
1665:
1657:
1655:
1653:
1649:
1648:B lymphocytes
1645:
1641:
1637:
1633:
1628:
1625:
1621:
1616:
1614:
1605:
1603:
1599:
1597:
1592:
1590:
1586:
1580:
1578:
1574:
1569:
1564:
1560:
1555:
1553:
1549:
1548:biorientation
1541:
1539:
1537:
1533:
1529:
1524:
1522:
1517:
1513:
1508:
1506:
1502:
1498:
1494:
1489:
1487:
1483:
1479:
1471:
1469:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1418:
1416:
1412:
1403:
1396:
1394:
1392:
1391:S. cerevisiae
1389:that altered
1388:
1384:
1376:
1374:
1372:
1368:
1363:
1361:
1352:
1350:
1348:
1344:
1340:
1336:
1332:
1320:
1315:
1311:
1307:
1304:
1300:
1293:
1291:
1288:
1284:
1280:
1276:
1273:
1269:
1265:
1258:
1256:
1250:
1246:
1243:
1237:
1235:
1231:
1227:
1223:
1217:
1213:
1209:
1205:
1201:
1197:
1193:
1190:
1186:
1179:
1177:
1171:
1167:
1164:
1158:
1156:
1152:
1148:
1144:
1138:
1134:
1130:
1126:
1122:
1118:
1114:
1111:
1109:RefSeq (mRNA)
1107:
1100:
1099:
1094:
1090:
1087:
1081:
1080:
1075:
1071:
1068:
1066:
1062:
1055:
1054:
1049:
1045:
1042:
1036:
1035:
1030:
1026:
1023:
1021:
1017:
1010:
1009:
1004:
1000:
997:
991:
990:
985:
981:
978:
976:
972:
969:
966:
964:
961:
957:
954:
950:
946:
939:
935:
930:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
828:cell division
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
760:
758:
755:
754:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
664:
662:
659:
658:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
589:
588:Gene ontology
585:
581:
569:
564:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
6877:Translocases
6874:
6861:
6848:
6835:
6822:
6812:Transferases
6809:
6796:
6653:Binding site
6084:P70S6 kinase
4734:
4733:
4722:
4716:
4703:
4697:
4652:
4648:
4609:
4605:
4574:
4570:
4531:
4527:
4478:
4474:
4435:
4431:
4400:
4396:
4365:
4361:
4330:
4326:
4289:
4285:
4250:
4246:
4207:
4204:J. Cell Biol
4203:
4156:
4152:
4134:(2): 123–8.
4131:
4127:
4105:(1–2): 1–7.
4102:
4098:
4065:
4061:
4044:
4040:
4014:
4010:
3979:(1): 21–32.
3976:
3972:
3919:
3915:
3905:
3870:
3866:
3856:
3829:
3825:
3815:
3798:
3794:
3788:
3745:
3741:
3731:
3704:
3700:
3690:
3655:
3652:J. Cell Biol
3651:
3641:
3606:
3602:
3592:
3565:
3561:
3551:
3508:
3504:
3494:
3467:
3463:
3453:
3418:
3414:
3404:
3369:
3365:
3355:
3312:
3308:
3298:
3263:
3259:
3249:
3227:(6): 903–7.
3224:
3220:
3214:
3179:
3175:
3135:
3131:
3121:
3086:
3082:
3072:
3045:
3041:
3031:
2996:
2992:
2982:
2939:
2935:
2925:
2893:(1): 25–39.
2890:
2886:
2876:
2841:
2837:
2827:
2792:
2788:
2778:
2743:
2739:
2729:
2694:
2690:
2680:
2653:
2649:
2603:
2599:
2593:
2558:
2554:
2544:
2501:
2497:
2487:
2452:
2448:
2438:
2393:
2389:
2379:
2342:
2339:PLOS Biology
2338:
2328:
2301:
2297:
2287:
2252:
2248:
2208:
2204:
2194:
2159:
2155:
2145:
2110:
2106:
2096:
2074:(2): 49–54.
2071:
2067:
2061:
2026:
2022:
1974:
1970:
1943:
1934:
1925:
1916:
1907:
1818:
1798:
1791:
1749:
1746:Interactions
1733:
1726:
1719:
1707:
1684:
1680:
1661:
1629:
1617:
1609:
1600:
1593:
1581:
1556:
1552:microtubules
1545:
1525:
1509:
1490:
1475:
1434:prometaphase
1419:
1408:
1380:
1364:
1356:
1330:
1329:
1252:
1230:NP_001300884
1226:NP_001300883
1222:NP_001300882
1219:
1212:NP_001300881
1208:NP_001300880
1204:NP_001300879
1200:NP_001271455
1196:NP_001243763
1173:
1151:NM_001284526
1147:NM_001256834
1143:NM_001313955
1140:
1133:NM_001313954
1129:NM_001313953
1125:NM_001313952
1121:NM_001313951
1117:NM_001313950
1096:
1077:
1051:
1032:
1006:
987:
967:
962:
798:human ageing
727:cytoskeleton
717:chromocenter
503:otic vesicle
499:otic placode
445:tibial nerve
399:
392:
119:External IDs
78:
6648:Active site
6535:(EC 2.7.12)
5922:Polo kinase
5862:Polo kinase
4292:(1): 11–7.
4286:Genes Cells
3748:(8): e759.
2345:(8): e207.
1664:cytokinesis
1632:metaphase I
1589:cytokinesis
1532:cytokinesis
1493:kinetochore
1422:chromosomes
1360:centrosomes
1347:cytokinesis
737:kinetochore
687:nucleoplasm
641:ATP binding
461:bone marrow
453:sural nerve
358:68,942,490
345:68,936,473
97:Identifiers
6920:Categories
6851:Isomerases
6825:Hydrolases
6692:Regulation
5213:IκB kinase
4788:2.7.11-12)
4153:Curr. Biol
4041:Cancer Res
1902:, May 2017
1881:, May 2017
1858:References
1809:cell death
1729:hesperadin
1672:Drosophila
1668:C. elegans
1640:anaphase I
1563:antibodies
1495:-specific
1458:Drosophila
1454:C. elegans
1430:centromere
1411:cell cycle
1343:centromere
868:cell cycle
763:abscission
692:chromosome
403:(ortholog)
257:8,210,600
244:8,204,733
140:HomoloGene
6931:EC 2.7.11
6730:EC number
5339:PKC alpha
4571:Dev. Cell
4001:205011994
3762:2041-4889
3329:1460-2075
1805:polyploid
1710:myosin II
1693:proteins
1620:condensin
1613:chromatin
1438:metaphase
1377:Discovery
1371:aneuploid
1367:cancerous
1255:NP_035626
1234:NP_004208
1176:NM_011496
1155:NM_004217
953:Orthologs
667:cytoplasm
148:GeneCards
6754:Kinetics
6678:Cofactor
6641:Activity
5695:KIAA0999
5590:MAPKAPK5
5585:MAPKAPK3
5580:MAPKAPK2
4671:14602875
4636:12925766
4593:12689593
4558:12686604
4515:12477932
4462:12466558
4419:12419797
4384:12082625
4362:Oncogene
4349:11976319
4314:23717416
4306:11856369
4277:11784863
4234:11756469
4183:11516652
4140:11471245
4090:46833128
3993:11413462
3946:29468257
3937:11105541
3897:21711447
3848:15562011
3780:23928698
3723:15064709
3701:Oncogene
3682:15249581
3633:17795816
3625:15260989
3584:12419797
3535:11516652
3486:19176389
3445:12719470
3396:12805209
3347:21407176
3290:12707311
3241:11098131
3206:12686604
3154:12458200
3064:11740938
3023:11940606
2966:12015116
2917:11809820
2868:11784863
2819:11266459
2770:16057773
2762:10975519
2721:14699064
2672:14960279
2628:29403722
2620:10600236
2585:12707311
2536:13939857
2528:12062053
2479:11352945
2430:18477699
2371:18752348
2320:14667408
2279:11756469
2227:12419797
2186:12925766
2137:11950924
2088:11166196
1898:–
1877:–
1824:See also
1801:BI811283
1752:interact
1695:vimentin
1568:syntelic
1482:Borealin
1478:Survivin
1446:anaphase
1426:prophase
1353:Function
1303:Wikidata
932:Sources:
519:epiblast
495:yolk sac
6910:Biology
6864:Ligases
6634:Enzymes
6354:MAP3K14
6332:MAP3K11
6327:MAP3K10
6317:MAP3K13
6312:MAP3K12
6114:RPS6KC1
6109:RPS6KA1
6104:RPS6KA3
6099:RPS6KA2
6094:RPS6KB2
6079:RPS6KA4
6074:RPS6KA5
5725:Kalirin
5690:SNF1LK2
4929:EIF2AK4
4924:EIF2AK3
4778:Kinases
4483:Bibcode
4225:2199334
4161:Bibcode
4119:9931403
4082:9858806
4053:9809983
4031:9514916
3954:3408586
3888:3822849
3771:3763433
3673:2172304
3513:Bibcode
3436:2172902
3338:3102279
3281:2172906
3113:9490714
3104:2132686
3014:1855215
2974:2215023
2944:Bibcode
2810:2195771
2576:2172906
2506:Bibcode
2470:2192373
2421:2438220
2398:Bibcode
2362:2525683
2270:2199334
2053:9450992
2044:1170416
2001:9606188
1992:1170645
1900:Ensembl
1879:Ensembl
1652:cohesin
1636:meiosis
1624:Xenopus
1497:histone
1415:mitosis
1387:kinases
1345:and in
1341:to the
1335:protein
1065:UniProt
1020:Ensembl
959:Species
938:QuickGO
732:nucleus
702:midbody
677:spindle
672:cytosol
378:pattern
236:17p13.1
104:Aliases
27:Protein
6896:Portal
6838:Lyases
6584:MAP2K7
6579:MAP2K6
6574:MAP2K5
6569:MAP2K4
6564:MAP2K3
6559:MAP2K2
6554:MAP2K1
6505:ACVRL1
6500:ACVR2B
6495:ACVR2A
6490:ACVR1C
6485:ACVR1B
6468:BMPR1B
6463:BMPR1A
6337:MAP3K7
6322:MAP3K9
6273:MAP3K8
6268:MAP3K7
6263:MAP3K6
6258:MAP3K5
6253:MAP3K4
6248:MAP3K3
6243:MAP3K2
6238:MAP3K1
6212:MAPK14
6207:MAPK13
6202:MAPK11
6190:MAPK10
6168:MAPK15
6163:MAPK12
6055:CDC2L1
6030:CDC2L5
5705:SNF1LK
5530:CAMK2G
5525:CAMK2D
5520:CAMK2B
5515:CAMK2A
5505:CAMK1G
5500:CAMK1D
5495:CAMK1B
5490:CAMK1A
5344:PRKCB1
5281:PRKACA
5276:PRKACB
5271:PRKACG
5247:IKBKAP
5073:BCKDHB
5068:BCKDHA
5042:PRKAG3
5037:PRKAG2
5032:PRKAG1
5022:PRKAB2
5017:PRKAB1
5007:PRKAA2
5002:PRKAA1
4847:STK38L
4714:Human
4695:Human
4692:(MeSH)
4669:
4634:
4627:181570
4624:
4591:
4556:
4549:153117
4546:
4513:
4506:139241
4503:
4460:
4453:137976
4450:
4417:
4382:
4347:
4312:
4304:
4275:
4268:133550
4265:
4232:
4222:
4191:381637
4189:
4181:
4138:
4117:
4088:
4080:
4051:
4029:
3999:
3991:
3952:
3944:
3934:
3895:
3885:
3846:
3778:
3768:
3760:
3721:
3680:
3670:
3631:
3623:
3582:
3543:381637
3541:
3533:
3484:
3443:
3433:
3394:
3387:162159
3384:
3345:
3335:
3327:
3288:
3278:
3239:
3204:
3197:153117
3194:
3152:
3111:
3101:
3062:
3021:
3011:
2972:
2964:
2915:
2905:
2866:
2859:133550
2856:
2817:
2807:
2768:
2760:
2719:
2712:363095
2709:
2670:
2626:
2618:
2583:
2573:
2534:
2526:
2477:
2467:
2428:
2418:
2369:
2359:
2318:
2277:
2267:
2225:
2184:
2177:181570
2174:
2135:
2128:102254
2125:
2086:
2051:
2041:
1999:
1989:
1847:INCENP
1754:with:
1699:desmin
1674:, and
1573:dynein
1501:serine
1486:INCENP
1456:, and
1428:, the
1289:search
1287:PubMed
1098:O70126
1079:Q96GD4
975:Entrez
549:BioGPS
515:somite
457:rectum
433:oocyte
136:107168
128:604970
6790:Types
6546:MAP2K
6480:ACVR1
6473:BMPR2
6458:BMPR1
6383:GSK-3
6224:MAP3K
6185:MAPK9
6180:MAPK8
6158:MAPK7
6153:MAPK6
6148:MAPK4
6143:MAPK3
6138:MAPK1
6050:PFTK1
6045:PCTK3
6040:PCTK2
6035:PCTK1
6025:CDK12
6020:CDK10
5995:CDKL5
5975:CDKL2
5852:STK19
5847:EEF2K
5828:PHKG2
5823:PHKG1
5813:PHKA2
5808:PHKA1
5789:MYLK4
5784:MYLK3
5779:MYLK2
5755:DCLK1
5750:Titin
5740:TRIB3
5735:TRIB2
5730:TRIB1
5720:TSSK2
5700:STK40
5685:PSKH1
5680:PRKD3
5675:PRKD2
5655:PHKG2
5650:PHKG1
5640:OBSCN
5635:NUAK2
5630:NUAK1
5625:MKNK2
5620:MKNK1
5610:MARK4
5605:MARK3
5600:MARK2
5595:MARK1
5575:STK11
5570:DAPK3
5565:DAPK2
5560:DAPK1
5555:CHEK2
5550:CHEK1
5535:CAMK4
5510:CAMK2
5485:CAMK1
5480:BRSK2
5374:PRKCQ
5369:PRKCI
5364:PRKCG
5359:PRKCH
5354:PRKCE
5349:PRKCD
5310:PRKG1
5242:IKBKG
5237:IKBKE
5186:STK10
5181:FASTK
5107:IDH3G
5102:IDH3B
5097:IDH3A
5063:BCKDK
4857:ROCK1
4842:STK38
4837:MAST2
4832:MAST1
4827:LATS2
4822:LATS1
4723:AURKB
4717:AURKB
4310:S2CID
4187:S2CID
4086:S2CID
3997:S2CID
3950:S2CID
3629:S2CID
3539:S2CID
2970:S2CID
2908:65070
2766:S2CID
2624:S2CID
2532:S2CID
1781:FBXL2
1775:TACC1
1770:CDCA8
1764:BIRC5
1759:BARD1
1740:BubR1
1521:BubR1
1503:7 by
1333:is a
1008:20877
968:Mouse
963:Human
934:Amigo
437:gonad
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
152:AURKB
144:55807
111:AURKB
33:AURKB
6882:list
6875:EC7
6869:list
6862:EC6
6856:list
6849:EC5
6843:list
6836:EC4
6830:list
6823:EC3
6817:list
6810:EC2
6804:list
6797:EC1
6373:TPK1
6349:CDC7
6307:MLKs
6300:KSR2
6295:KSR1
6290:BRAF
6285:ARAF
6280:RAFs
6015:CDK9
6010:CDK8
6005:CDK7
6000:CDK6
5990:CDK5
5985:CDK4
5980:CDK3
5970:CDK2
5965:CDK1
5946:PLK4
5941:PLK3
5936:PLK2
5931:PLK1
5886:PLK4
5881:PLK3
5876:PLK2
5871:PLK1
5818:PHKB
5774:MYLK
5745:TRIO
5715:SPEG
5710:SNRK
5670:PKD1
5665:PIM2
5660:PIM1
5645:PASK
5615:MELK
5545:CASK
5540:MLCK
5461:GRK6
5456:GRK5
5451:GRK4
5389:PKN3
5384:PKN2
5286:PRKY
5232:TBK1
5227:IKK2
5222:CHUK
5126:STK4
5092:IDH2
4977:PDK4
4972:PDK3
4967:PDK2
4962:PDK1
4941:WEE1
4936:Wee1
4904:mTOR
4892:AKT3
4887:AKT2
4882:AKT1
4872:SGK3
4867:SGK2
4704:AIM1
4698:AIM1
4667:PMID
4632:PMID
4589:PMID
4554:PMID
4511:PMID
4458:PMID
4415:PMID
4380:PMID
4345:PMID
4302:PMID
4273:PMID
4230:PMID
4179:PMID
4136:PMID
4115:PMID
4099:Gene
4078:PMID
4049:PMID
4027:PMID
3989:PMID
3942:PMID
3893:PMID
3844:PMID
3776:PMID
3758:ISSN
3719:PMID
3678:PMID
3621:PMID
3603:Cell
3580:PMID
3531:PMID
3482:PMID
3441:PMID
3392:PMID
3343:PMID
3325:ISSN
3286:PMID
3237:PMID
3202:PMID
3150:PMID
3109:PMID
3060:PMID
3019:PMID
2962:PMID
2913:PMID
2864:PMID
2815:PMID
2758:PMID
2740:Cell
2717:PMID
2668:PMID
2616:PMID
2581:PMID
2524:PMID
2475:PMID
2426:PMID
2367:PMID
2316:PMID
2275:PMID
2223:PMID
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