306:
prevention strategies to deliver improved health outcomes. The endogamous Parsi community is characterized by greater longevity, fewer cases of lung, head, neck and esophageal cancers. At the same time, there is increased prevalence of
Parkinson's & Alzheimer's diseases, cardiovascular disease, breast and prostate cancer, and male and female infertility. A pilot study by Avesthagen Limited into the prevalence of breast cancer biomarkers and metabolite signatures indicated unique signatures that are currently undergoing further validation in larger cohorts
356:
etiology of disease". The work identified 5258 disease relevant genes differentially methylated across this individual over 12 years and 24,948 genes corresponding to 4,58,148 variants specific to ZPMetG-Hv2a-1B, indicative of variants that accrued over time providing an understanding of the ageing methylome over time through the interplay between differentially methylated genes and variants in the etiology of disease.
134:
396:, sourced from traditional Indian medicine which we have researched and developed using ADePt, Avesta Nordic's proprietary bioactive discovery engine and information management platform and MetaGrid, the proprietary bioactive testing methodology. In May 2008, we launched Teestar, our first ADePt and MetaGrid derived bioactive, which we clinically demonstrated to reduce blood glucose levels.
68:
27:
373:
Avgen
Biopharma has successfully completed both toxicity and efficacy studies for Avent. Pre-clinical Efficacy of Avent was carried out in a USFDA accredited human TNF transgenic murine model of Rheumatoid Arthritis and the biosimilar has demonstrated high structural and pre-clinical similarity with etanercept
747:
Patell, Villoo
Morawala; Pasha, Naseer; Krishnasamy, Kashyap; Mittal, Bharti; Gopalakrishnan, Chellappa; Mugasimangalam, Raja; Sharma, Naveen; Gupta, Arati-Khanna; Bhote-Patell, Perviz; Rao, Sudha; Jain, Renuka (7 January 2021). "The First Complete Zoroastrian-Parsi Mitochondrial Reference Genome and
355:
In 2020, Avesthagen released a pre-print of their work on the whole genome methylation and variant analysis in one
Zoroastrian-Parsi non-smoking individual, collected at an interval of 12 years apart on biorXiv titled "Dynamic Methylome Modification associated with mutational signatures in ageing and
342:
In a new paper, available on bioRxiv in 2020, Avesthagen researchers characterized the genetic traits specific to the
Zoroastrian-Parsi population—a community that has historically abstained from smoking. Because of this unique social practice, Zoroastrian-Parsi genes may help scientists characterize
388:
Avesthagen's DHA from algal sources will also provide the much need omega-3 fatty acids to vegetarians. The company is in the process of developing a manufacturing alliance for AvestaDHA and has developed a marketing alliances for its bioactives and DHA with a large beverage player in India, a large
372:
Avent: Biosimilar version of etanercept, which targets autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis and psoriasis. RCGM, after reviewing analytical characterization data on Avent, granted permission in
January 2009 to conduct pre-clinical toxicity and efficacy studies.
364:
Avgen Pharma, Avesthagen's biopharmaceuticals business develops biosimilars and antibody therapeutics for oncology, auto-immune, cardiovascular–targeted biologics. Avgen Pharma owns 8 biosimilar molecules with patents, processes, manufacturing rights for global licensing and sales & marketing
305:
was created to identify genetic risk factors within the Parsi population that predispose individuals to cancers and high morbidity diseases. Its database of genomic variants derived from the Parsi control population is used with other populations to identify early intervention and improve disease
346:
To obtain a complete picture of population-specific variants, the
Avesthagen team analyzed one hundred Zoroastrian-Parsi mitochondrial genomes to generate a “consensus genome.” This is a process that combines genetic information from a large number of individuals to determine the genetic traits
329:, bioinformatics, artificial intelligence and machine learning to identify predictive and early-stage biomarkers of cancers in smokers. The project will use non-Parsi smoker and non-smoker samples from the wider Indian and other populations to gain insights into the evidence behind such data.
325:. The Foundation for a Smoke-Free World has awarded Villoo Morawala-Patell a grant of 2.29M USD to explore “Cancer risk in smoking subjects assessed by next generation sequencing profile of circulating free DNA and RNA.” The work carried out at Avesthagen Limited will combine liquid biopsy,
293:, a Rockefeller Fellow and grantee within NCBS-UAS, Bangalore. Avesthagen started business operations on March 21, 2001 with Series-A round investment led by ICICI Ventures and Tata Industries. Villoo Morawala Patell, is the Chairperson and Managing Director of Avesthagen Limited.
821:
Kumar, Gayathri; Krishnasamy, Kashyap; Pasha, Naseer; Nagarajan, Naveenkumar; Mam, Bhavika; Kishinani, Mahima; Vohra, Vedanth; Patell, Villoo
Morawala (22 December 2020). "Dynamic Methylome Modification associated with mutational signatures in ageing and etiology of disease".
868:
Maity, Sunit; Ullanat, Rajesh; Lahiri, Subhra; Shekar, Sunil; Sodhan, Geetha; Vyas, Ashutosh; Dyaga, Gopal; Ireni, Srinivas; Nair, Nirmala; Sotsios, Yannis; Maria, Denis C. (November 2011). "A non-innovator version of etanercept for treatment of arthritis".
313:
community with a target of 15,000 Parsis globally by 2021. The molecular basis of longevity and age-related disorders, prioritising cancers, cardiovascular disease, diabetes and neurological disorders will be investigated in this cohort specifically.
211:
769:
404:
Avesthagen's subsidiary, AVA Seeds is engaged in the development of novel seed research, application of molecular markers and transgene based technologies to develop more productive food, feed, fuel and fiber based products.
408:
The company as part of its sustainability initiative developed BioPercept, a biocompostable plastic made from renewable resources that breaks down and decomposes, under industrial composting conditions, within 120 days.
795:
379:
Avplase is
Avesthagen biosimilar version of Tenectaplase (also known as tPA) which targets acute myocardial infarction. Avgen Biopharma has developed stable cell lines for the production of Tenectplase.
696:
1190:
1231:
417:
In 2012, the company ran out of money and saw a number of exits by senior executives. Also in 2012, several former staff filed criminal and civil charges against the company.
376:
Avcade is
Avesthagen biosimilar version of Infliximab targeting Crohn's Disease and rheumatoid arthritis. Avgen Biopharma has developed stable cell lines to produce Infliximab.
347:
typical to that population. The mitochondrial DNA of one hundred Zoroastrian-Parsi individuals sequenced created the “consensus mitochondrial genome” (AGENOME-ZPMCG V 1.0).
1118:
770:"Avesthagen Releases First Complete Zoroastrian-Parsi Mitochondria Reference Genome: 'Implications Of Mitochondrial Signatures In An Endogamous, Non-Smoking Population'"
583:
1156:
671:
1092:
1066:
938:
796:"The First complete Zoroastrian-Parsi Mitochondria Reference Genome: Implications of mitochondrial signatures in an endogamous, non-smoking population"
392:
The key products and product candidates are based upon, or include as a primary ingredient, scientifically and clinically validated plant extracts, or
1236:
1221:
989:
964:
912:
434:
1151:
645:
1015:
1226:
78:
1166:
722:
309:
Since 2008, the Avestagenome Project has collected blood samples and extensive patient data from over 4,500 members of the Zoroastrian-
150:
97:
318:
190:
172:
115:
54:
143:
532:
Guzder, S. N.; Jain, Renuka; Sharma, Naveen; Gopalkrishnan, Chellappa; Shah, Yasmin; Morawala-Patell, Villoo (11 October 2010).
365:
rights. The biosimilars listed below have completed preclinical trials and are ready to enter clinical trials for validation.
1040:
1161:
369:
Avdesp: Biosimilar version of Darbepoetinalfa for treatment of chronic kidney disease and chemotherapy-induced anaemia
322:
40:
1203:
93:
326:
1195:
1182:
1174:
461:
343:
biomarkers predictive of diseases caused by tobacco use, such as lung, head and neck, and esophagus cancers.
302:
290:
242:
577:
597:
Bharucha, N. E.; Bharucha, E. P.; Bharucha, A. E.; Bhise, A. V.; Schoenberg, B. S. (1 December 1988).
351:
Dynamic Methylome Modification associated with mutational signatures in ageing and etiology of disease
823:
749:
723:"Groundbreaking Avesthagen Study Aimed at Early Detection of Cancers and Other Diseases Announced"
697:"Groundbreaking Avesthagen Study Aimed at Early Detection of Cancers and Other Diseases Announced"
598:
1191:
Presentation by CEO, October 2003, at US-Asia Technology Management Center, Stanford University
894:
886:
626:
618:
555:
514:
506:
89:
1162:"Avesthagen signs MOU with CosmosID™ for Improving Diagnosis and Management of Tuberculosis"
878:
610:
563:
545:
496:
286:
231:
154:
46:
614:
338:
AGENOME-ZPMS-HV2a-1: The first complete Zoroastrian Parsi Mitochondrial Reference Genome
568:
533:
221:
149:
It may require cleanup to comply with Knowledge (XXG)'s content policies, particularly
882:
1215:
534:"The Avestagenome project™ - a discovery model for disease genomics and beyond"
843:
828:
754:
550:
890:
622:
559:
510:
253:
898:
599:"Prevalence of Parkinson's Disease in the Parsi Community of Bombay, India"
518:
630:
501:
484:
210:
310:
435:"Avesthagen to raise $ 60 mn in complex deal from Cayman-based fund"
285:
is an integrated systems biology platform company headquartered in
1119:"Avesthagen in a spot as former staff file criminal, civil cases"
965:"Avesthagen Nutrition Unit takes bite out of global pie for DHA"
913:"Avesthagen validates commercialization of new vegetarian DHA"
127:
61:
20:
748:
genetic signatures of an endogamous non-smoking population".
1146:
269:
1197:
Avestha Gengraine gets US patents for multiple use tech
85:
672:"Avestha's Parsi project finds leads to breast cancer"
142:
A major contributor to this article appears to have a
1157:"Avesthagen plans to raise between Rs 500-600 crore"
96:, and by adding encyclopedic content written from a
289:. It was founded as an academic startup in 1998 by
264:
248:
238:
227:
217:
317:In 2019, this initiative received support by the
1152:"Avesthagen to focus on health agri verticals"
939:"Avesthagen in licensing pact for animal feed"
389:MNC retailer and a large Indian conglomerate.
990:"Avestha takes next step in plant bioactives"
8:
582:: CS1 maint: DOI inactive as of June 2024 (
203:
1232:Biotechnology companies established in 1998
1207:, Business Standard Wednesday, 22 Jun 2011
1067:"Avesthagen launches biodegradable plastic"
55:Learn how and when to remove these messages
1186:, The Hindu Business Line, 25 October 2005
1176:Avesthagen ties up with French seeds major
209:
202:
827:
753:
567:
549:
500:
191:Learn how and when to remove this message
173:Learn how and when to remove this message
116:Learn how and when to remove this message
1168:Avesthagen to acquire two seed companies
1093:"Avesthagen in a freeze as funds dry up"
1041:"Avesthagen announces launch of Teestar"
1178:, The Hindu Business Line, 21 July 2006
1016:"Avesthagen launches bioactive Teestar"
426:
575:
462:"Decoding the longevity DNA of Parsis"
384:Avesta Nordic Research Private Limited
77:contains content that is written like
1184:Avesthagen to invest Rs 45 crore more
301:The Avestagenome Project, founded by
7:
646:"Parsis more prone to cancer: study"
615:10.1001/archneur.1988.00520360039008
644:Bawa, Ravinder (26 December 2000).
1117:Badrinath, Raghuvir (8 May 2012).
16:Indian biological products company
14:
1199:, The Economic Times, 10 Sep 2003
883:10.1016/j.biologicals.2011.08.014
670:Shrikant, Rashmi (19 June 2009).
485:"Profile: Villoo Morawala Patell"
319:Foundation for a Smoke-Free World
36:This article has multiple issues.
1237:1998 establishments in Karnataka
1222:Biotechnology companies of India
483:Jayaraman, K. S. (1 July 2007).
153:. Please discuss further on the
132:
66:
25:
44:or discuss these issues on the
1:
1227:Companies based in Bangalore
1205:Avesthagen granted US patent
1147:Avesthagen Official website
323:Philip Morris International
1253:
327:next-generation sequencing
829:10.1101/2020.12.22.423778
755:10.1101/2020.06.05.124891
554:(inactive 16 June 2024).
551:10.1186/gb-2010-11-s1-p16
464:. The Hindu Business Line
208:
1170:, The Hindu, 10 Sep 2006
969:www.biospectrumindia.com
1123:Business Standard India
1071:Business Standard India
994:Business Standard India
943:Business Standard India
848:www.thepharmaletter.com
676:Business Standard India
917:foodnavigator-asia.com
303:Villoo Morawala Patell
291:Villoo Morawala-Patell
243:Villoo Morawala-Patell
603:Archives of Neurology
151:neutral point of view
98:neutral point of view
489:Nature Biotechnology
297:Avestagenome Project
502:10.1038/nbt0707-705
460:P.T. Jyothi Datta.
333:Recent publications
205:
90:promotional content
1097:The Times of India
1020:The Economic Times
919:. 17 February 2011
701:www.prnewswire.com
650:The Times of India
283:Avesthagen Limited
204:Avesthagen Limited
92:and inappropriate
609:(12): 1321–1323.
439:Business Standard
280:
279:
201:
200:
193:
183:
182:
175:
146:with its subject.
126:
125:
118:
59:
1244:
1134:
1133:
1131:
1129:
1114:
1108:
1107:
1105:
1103:
1089:
1083:
1082:
1080:
1078:
1063:
1057:
1056:
1054:
1052:
1045:www.oneindia.com
1037:
1031:
1030:
1028:
1026:
1012:
1006:
1005:
1003:
1001:
986:
980:
979:
977:
975:
961:
955:
954:
952:
950:
945:. 27 August 2013
935:
929:
928:
926:
924:
909:
903:
902:
865:
859:
858:
856:
854:
840:
834:
833:
831:
818:
812:
811:
809:
807:
800:Zoroastrians.net
792:
786:
785:
783:
781:
766:
760:
759:
757:
744:
738:
737:
735:
733:
719:
713:
712:
710:
708:
693:
687:
686:
684:
682:
667:
661:
660:
658:
656:
641:
635:
634:
594:
588:
587:
581:
573:
571:
553:
529:
523:
522:
504:
480:
474:
473:
471:
469:
457:
451:
450:
448:
446:
431:
287:Bangalore, India
276:
273:
271:
232:Bangalore, India
213:
206:
196:
189:
178:
171:
167:
164:
158:
144:close connection
136:
135:
128:
121:
114:
110:
107:
101:
79:an advertisement
70:
69:
62:
51:
29:
28:
21:
1252:
1251:
1247:
1246:
1245:
1243:
1242:
1241:
1212:
1211:
1143:
1138:
1137:
1127:
1125:
1116:
1115:
1111:
1101:
1099:
1091:
1090:
1086:
1076:
1074:
1065:
1064:
1060:
1050:
1048:
1047:. 23 April 2008
1039:
1038:
1034:
1024:
1022:
1014:
1013:
1009:
999:
997:
996:. 25 March 2008
988:
987:
983:
973:
971:
963:
962:
958:
948:
946:
937:
936:
932:
922:
920:
911:
910:
906:
867:
866:
862:
852:
850:
842:
841:
837:
820:
819:
815:
805:
803:
794:
793:
789:
779:
777:
768:
767:
763:
746:
745:
741:
731:
729:
721:
720:
716:
706:
704:
703:(Press release)
695:
694:
690:
680:
678:
669:
668:
664:
654:
652:
643:
642:
638:
596:
595:
591:
574:
531:
530:
526:
482:
481:
477:
467:
465:
459:
458:
454:
444:
442:
433:
432:
428:
423:
415:
402:
386:
362:
335:
299:
268:
260:
256:
197:
186:
185:
184:
179:
168:
162:
159:
148:
137:
133:
122:
111:
105:
102:
83:
71:
67:
30:
26:
17:
12:
11:
5:
1250:
1248:
1240:
1239:
1234:
1229:
1224:
1214:
1213:
1210:
1209:
1201:
1193:
1188:
1180:
1172:
1164:
1159:
1154:
1149:
1142:
1141:External links
1139:
1136:
1135:
1109:
1084:
1073:. 8 April 2008
1058:
1032:
1007:
981:
956:
930:
904:
877:(6): 384–395.
860:
835:
813:
802:. 16 June 2020
787:
776:. 20 June 2020
761:
739:
714:
688:
662:
636:
589:
538:Genome Biology
524:
475:
452:
425:
424:
422:
419:
414:
411:
401:
398:
385:
382:
381:
380:
377:
374:
370:
361:
358:
334:
331:
298:
295:
278:
277:
266:
262:
261:
258:
252:
250:
246:
245:
240:
236:
235:
229:
225:
224:
219:
215:
214:
199:
198:
181:
180:
140:
138:
131:
124:
123:
94:external links
74:
72:
65:
60:
34:
33:
31:
24:
15:
13:
10:
9:
6:
4:
3:
2:
1249:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1219:
1217:
1208:
1206:
1202:
1200:
1198:
1194:
1192:
1189:
1187:
1185:
1181:
1179:
1177:
1173:
1171:
1169:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1144:
1140:
1124:
1120:
1113:
1110:
1098:
1094:
1088:
1085:
1072:
1068:
1062:
1059:
1046:
1042:
1036:
1033:
1021:
1017:
1011:
1008:
995:
991:
985:
982:
970:
966:
960:
957:
944:
940:
934:
931:
918:
914:
908:
905:
900:
896:
892:
888:
884:
880:
876:
872:
864:
861:
849:
845:
839:
836:
830:
825:
817:
814:
801:
797:
791:
788:
775:
771:
765:
762:
756:
751:
743:
740:
728:
724:
718:
715:
702:
698:
692:
689:
677:
673:
666:
663:
651:
647:
640:
637:
632:
628:
624:
620:
616:
612:
608:
604:
600:
593:
590:
585:
579:
570:
565:
561:
557:
552:
547:
543:
539:
535:
528:
525:
520:
516:
512:
508:
503:
498:
494:
490:
486:
479:
476:
463:
456:
453:
441:. 12 May 2012
440:
436:
430:
427:
420:
418:
412:
410:
406:
399:
397:
395:
390:
383:
378:
375:
371:
368:
367:
366:
359:
357:
353:
352:
348:
344:
340:
339:
332:
330:
328:
324:
320:
315:
312:
307:
304:
296:
294:
292:
288:
284:
275:
267:
263:
255:
251:
247:
244:
241:
237:
233:
230:
226:
223:
220:
216:
212:
207:
195:
192:
177:
174:
166:
156:
152:
147:
145:
139:
130:
129:
120:
117:
109:
99:
95:
91:
87:
81:
80:
75:This article
73:
64:
63:
58:
56:
49:
48:
43:
42:
37:
32:
23:
22:
19:
1204:
1196:
1183:
1175:
1167:
1128:18 September
1126:. Retrieved
1122:
1112:
1102:18 September
1100:. Retrieved
1096:
1087:
1075:. Retrieved
1070:
1061:
1049:. Retrieved
1044:
1035:
1023:. Retrieved
1019:
1010:
998:. Retrieved
993:
984:
972:. Retrieved
968:
959:
947:. Retrieved
942:
933:
921:. Retrieved
916:
907:
874:
870:
863:
851:. Retrieved
847:
838:
816:
804:. Retrieved
799:
790:
778:. Retrieved
773:
764:
742:
730:. Retrieved
726:
717:
705:. Retrieved
700:
691:
679:. Retrieved
675:
665:
653:. Retrieved
649:
639:
606:
602:
592:
578:cite journal
541:
537:
527:
492:
488:
478:
466:. Retrieved
455:
443:. Retrieved
438:
429:
416:
407:
403:
393:
391:
387:
363:
360:Avgen Pharma
354:
350:
349:
345:
341:
337:
336:
316:
308:
300:
282:
281:
249:Headquarters
218:Company type
187:
169:
160:
141:
112:
103:
88:by removing
84:Please help
76:
52:
45:
39:
38:Please help
35:
18:
871:Biologicals
774:Parsi Times
468:23 February
272:.avesthagen
1216:Categories
1077:29 January
1051:29 January
1025:29 January
1000:29 January
974:29 January
949:29 January
923:29 January
853:28 January
806:29 January
780:29 January
732:29 January
707:29 January
681:29 January
655:29 January
495:(7): 705.
421:References
413:Criticisms
394:bioactives
86:improve it
41:improve it
891:1095-8320
623:0003-9942
560:1474-760X
544:(1): 16.
511:1546-1696
400:AVA Seeds
254:Bangalore
155:talk page
47:talk page
899:21996051
844:"Avdesp"
727:The Week
519:17621282
163:May 2024
106:May 2024
824:bioRxiv
750:bioRxiv
631:3264148
569:3026244
445:16 July
265:Website
239:Founder
228:Founded
897:
889:
826:
752:
629:
621:
566:
558:
517:
509:
234:, 1998
222:Public
311:Parsi
259:India
1130:2018
1104:2018
1079:2021
1053:2021
1027:2021
1002:2021
976:2021
951:2021
925:2021
895:PMID
887:ISSN
855:2021
808:2021
782:2021
734:2021
709:2021
683:2021
657:2021
627:PMID
619:ISSN
584:link
556:ISSN
515:PMID
507:ISSN
470:2008
447:2012
274:.com
879:doi
611:doi
564:PMC
546:doi
497:doi
321:of
270:www
1218::
1121:.
1095:.
1069:.
1043:.
1018:.
992:.
967:.
941:.
915:.
893:.
885:.
875:39
873:.
846:.
798:.
772:.
725:.
699:.
674:.
648:.
625:.
617:.
607:45
605:.
601:.
580:}}
576:{{
562:.
542:11
540:.
536:.
513:.
505:.
493:25
491:.
487:.
437:.
257:,
50:.
1132:.
1106:.
1081:.
1055:.
1029:.
1004:.
978:.
953:.
927:.
901:.
881::
857:.
832:.
810:.
784:.
758:.
736:.
711:.
685:.
659:.
633:.
613::
586:)
572:.
548::
521:.
499::
472:.
449:.
194:)
188:(
176:)
170:(
165:)
161:(
157:.
119:)
113:(
108:)
104:(
100:.
82:.
57:)
53:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
