20:
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155:
174:
234:
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Morooka, M.; Ohba, S.; Toriumi, K. (1992). "Electron-density distribution in crystals of 1,4,7,10,13,16-hexaazacyclooctadecanecobalt(III) trichloride, meso-[Co(hexaen)]Cl3 at 106 K".
427:
Bencini, Andrea; Bianchi, Antonio; Garcia-España, Enrique; Micheloni, Mauro; Ramirez, José Antonio (1999). "Proton coordination by polyamine compounds in aqueous solution".
173:
154:
210:
650:
Gokel, G. W.; Barbour, L. J.; Ferdani, R.; Hu, J. (2002). "Lariat Ether
Receptor Systems Show Experimental Evidence for Alkali Metal Cation Interactions".
160:
233:
454:
Reichenbach-Klinke, Roland; König, Burkhard (2002). "Metal complexes of azacrown ethers in molecular recognition and catalysis".
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Krakowiak, Krzysztof E.; Bradshaw, Jerald S.; Zamecka-Krakowiak, Daria J. (1989). "Synthesis of aza-crown ethers".
349:
710:
695:
700:
705:
164:
596:
Frensdorff, Hans K. (1971). "Stability constants of cyclic polyether complexes with univalent cations".
19:
715:
690:
273:
252:
The synthesis of aza crown ethers are subject to the challenges associated with the preparation of
142:
667:
551:
507:
Atkins, T. J.; Richman, J. E.; Oettle, W. F. (1978). "1,4,7,10,13,16-Hexaazacyclooctadecane".
134:
52:
44:
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632:
605:
578:
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516:
486:
459:
436:
409:
281:
224:
92:
88:
623:
Gatto, Vincent J.; Miller, Steven R.; Gokel, George W. (1990). "4,13-Diaza-18-Crown-6".
328:
In many aza-crown ethers some or all of the amines are tertiary. One example is the tri(
329:
269:
239:
440:
684:
547:
277:
56:
413:
253:
216:
636:
520:
490:
671:
555:
477:
Reed, David P.; Weisman, Gary R. (2002). "1,4,7,10-Tetraazacyclododecane".
268:
can be synthesized by combining two triamine components. By reaction with
384:
crown ethers, which feature sidearms that augment complexation of cation.
353:
220:
60:
609:
582:
663:
463:
381:
317:
179:
138:
76:
80:
64:
18:
356:, three-dimensional aza crowns, feature tertiary amines.
133:, where n = 3, 4, 5, 6. Well-studied aza crowns include
368:
ether and amines.. One example is the diaza-18-crown-6,
39:. Color code: blue = N, gray = C, black = C, white = H.
16:
Ring molecule with several amine (–N– or >N–) groups
456:
Journal of the
Chemical Society, Dalton Transactions
402:
364:Another large class of macrocyclic ligands feature
380:The presence of the amine allows the formation of
242:is an aza-crown of the mixed ether-amine variety.
280:. This compound serves as a building block for
276:is converted to a derivative with two secondary
8:
219:, a derivative of cyclam, is used to treat
182:is a tetraaza crown ether with alternating
300:Aza crowns often feature trimethylene ((CH
598:Journal of the American Chemical Society
502:
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292:Many kinds of aza crown ethers exist.
200:
196:
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127:
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98:
34:
30:
26:
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161:1,4,7-Trimethyl-1,4,7-triazacyclononane
149:Selected aza-crowns and their complexes
147:
59:(cyclic polyether). That is, it has a
320:(1,4,8,11-tetraazacyclotetradecane).
7:
14:
548:10.2165/00126839-200708020-00006
232:
209:
172:
153:
116:-crown ethers have the formulae
95:crown ethers have the formulae
429:Coordination Chemistry Reviews
204:linkers between amine centers.
163:, a tridentate ligand used in
1:
441:10.1016/S0010-8545(98)00243-4
256:. The 18-membered ring in (CH
316:) linkages. One example is
732:
350:trimethyltriazacyclononane
308:) as well as ethylene ((CH
414:10.1107/S0108768192002714
360:Mixed ether-amine ligands
637:10.15227/orgsyn.068.0227
521:10.15227/orgsyn.058.0086
491:10.15227/orgsyn.078.0073
296:Variable length linkers
165:coordination chemistry
40:
22:
542:(2): 113–119. 2007.
610:10.1021/ja00732a007
583:10.1021/cr00094a008
274:diethylene triamine
75:) in place of each
143:hexaaza-18-crown-6
41:
664:10.1021/ar000093p
625:Organic Syntheses
282:macrocyclizations
135:triazacyclononane
45:organic chemistry
23:The structure of
723:
711:Chelating agents
696:Secondary amines
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571:Chemical Reviews
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536:Drugs in R&D
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464:10.1039/b106367g
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225:multiple myeloma
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701:Tertiary amines
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658:(10): 878–886.
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49:aza-crown ether
36:
32:
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25:[Co(III)(CH
24:
17:
12:
11:
5:
729:
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719:
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713:
708:
706:Ethyleneamines
703:
698:
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652:Acc. Chem. Res
642:
615:
604:(3): 600–606.
588:
577:(4): 929–972.
561:
534:"Plerixafor".
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496:
469:
458:(2): 121–130.
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419:
408:(4): 459–463.
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389:
386:
378:
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376:Lariate crowns
369:
362:
361:
345:
341:
337:
333:
330:tertiary amine
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270:tosyl chloride
265:
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240:2.2.2-Cryptand
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141:(n = 4), and
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112:, the parent
109:
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87:) around the
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278:sulfonamides
251:
128:
113:
107:
91:. While the
48:
42:
716:Macrocycles
348:, known as
254:macrocycles
57:crown ether
691:Polyamines
685:Categories
509:Org. Synth
479:Org. Synth
435:: 97–156.
388:References
217:Plerixafor
51:is an aza
354:Cryptands
248:Synthesis
145:(n = 6).
137:(n = 3),
83:linkage,
67:linkage,
672:12379140
556:17324009
288:Variants
221:lymphoma
61:nitrogen
53:analogue
631:: 227.
670:
554:
515:: 86.
485:: 73.
382:Lariat
318:cyclam
180:Cyclam
139:cyclen
93:parent
79:atom (
77:oxygen
73:>N−
63:atom (
332:) (CH
81:ether
65:amine
55:of a
47:, an
668:PMID
552:PMID
366:both
223:and
193:and
89:ring
69:−NH−
660:doi
633:doi
606:doi
579:doi
544:doi
517:doi
487:doi
460:doi
437:doi
433:188
410:doi
340:NCH
264:NH)
195:(CH
184:(CH
126:NH)
118:(CH
114:aza
97:(CH
85:−O−
71:or
43:In
33:NH)
687::
666:.
656:35
654:.
629:68
627:.
602:93
600:.
575:89
573:.
550:.
538:.
513:58
511:.
499:^
483:78
481:.
431:.
406:48
404:.
372:.
352:.
336:CH
284:.
272:,
260:CH
122:CH
105:O)
101:CH
29:CH
674:.
662::
639:.
635::
612:.
608::
585:.
581::
558:.
546::
540:8
523:.
519::
493:.
489::
466:.
462::
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439::
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412::
370:2
346:3
344:)
342:3
338:2
334:2
314:2
312:)
310:2
306:3
304:)
302:2
266:6
262:2
258:2
227:.
201:3
199:)
197:2
190:2
188:)
186:2
167:.
129:n
124:2
120:2
108:n
103:2
99:2
37:]
35:6
31:2
27:2
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