339:
78:
22:
662:
Burstein, A.H.; Sabbagh, M.; Andrews, R.; Valcarce, C.; Dunn, I.; Altstiel, L. (2018). "DEVELOPMENT OF AZELIRAGON, AN ORAL SMALL MOLECULE ANTAGONIST OF THE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS, FOR THE POTENTIAL SLOWING OF LOSS OF COGNITION IN MILD ALZHEIMER'S DISEASE".
618:
Kong, Weikang; Zhu, Lingxia; Li, Tian; Chen, Jiao; Fan, Bo; Ji, Wenjing; Zhang, Chunli; Cai, Xueting; Hu, Chunping; Sun, Xiaoyan; Cao, Peng (June 2023). "Azeliragon inhibits PAK1 and enhances the therapeutic efficacy of AKT inhibitors in pancreatic cancer".
796:
Ma, Simeng; Nakamura, Yoki; Hisaoka-Nakashima, Kazue; Morioka, Norimitsu (February 2023). "Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy".
840:
Joshi, Aditi A.; Wu, Ying; Deng, Songyan; Preston-Hurlburt, Paula; Forbes, Josephine M.; Herold, Kevan C. (December 2022). "RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice".
517:
Magna, Melinda; Hwang, Gyong Ha; McIntosh, Alec; Drews-Elger, Katherine; Takabatake, Masaru; Ikeda, Adam; Mera, Barbara J.; Kwak, Taekyoung; Miller, Philip; Lippman, Marc E.; Hudson, Barry I. (13 July 2023).
496:
The chemical reached Phase III trials in slowing cognitive deterioration in early stage
Alzheimer's disease patients. It was also tested in people with diabetic neuropathy and animal models of
140:
575:
Xie, Jizhao; Xu, Huanji; Wu, Xinduo; Xie, Yunfeng; Lu, Xiuhong; Wang, Lisheng (December 2021). "Design, synthesis and anti-TNBC activity of
Azeliragon triazole analogues".
362:
InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
757:"Effects of azeliragon on ADASācog and CDR domains and individual items in patients with mild Alzheimer's disease and type 2 diabetes (T2D): Human/Human trials: Other"
378:
708:"Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway"
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520:"RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer"
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Burstein, Aaron H.; Dunn, Imogene; Gooch, Ann M.; Valcarce, Carmen (December 2020).
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inhibitor. It is developed by vTv
Therapeutics for various cancers, including
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Yang, Lijuan; Liu, Yepei; Wang, Yuanyuan; Li, Junsheng; Liu, Na (2021).
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Except where otherwise noted, data are given for materials in their
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CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
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94:3-imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
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761:Alzheimer's & Dementia
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891:Diethylamino compounds
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460:Infobox references
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100:Identifiers
56:
30:
480:PF-04494700
395:Properties
117:603148-36-3
71:Azeliragon
901:Imidazoles
885:Categories
849:: 109165.
805:: 105470.
627:: 175703.
583:: 128444.
504:References
472:Azeliragon
439:Molar mass
306:LPU25F15UQ
231:IUPHAR/BPS
172:ChemSpider
128:3D model (
107:CAS Number
91:IUPAC name
59:March 2024
50:; try the
37:link to it
871:252979084
827:255113751
783:227500289
718:: e2348.
649:258019889
605:243976660
544:2374-4677
530:(1). 59.
221:814-441-9
213:EC Number
40:. Please
863:36257528
819:36581174
742:33681944
685:29616709
641:37028543
597:34763082
562:37443146
553:10344964
286:11180124
192:DrugBank
733:7920406
712:Clinics
693:4592148
482:) is a
273:PubChem
201:DB12689
181:9355214
869:
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825:
817:
781:
767:(S9).
740:
730:
691:
683:
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542:
476:TTP488
444:532.13
379:SMILES
261:D11147
152:ChEMBL
85:Names
33:orphan
31:is an
867:S2CID
823:S2CID
779:S2CID
689:S2CID
645:S2CID
601:S2CID
354:InChI
130:JSmol
859:PMID
815:PMID
738:PMID
681:PMID
637:PMID
593:PMID
558:PMID
540:ISSN
487:RAGE
297:UNII
252:KEGG
241:8317
851:doi
847:245
807:doi
803:163
769:doi
728:PMC
720:doi
673:doi
629:doi
625:948
585:doi
548:PMC
532:doi
478:or
323:EPA
276:CID
887::
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
