320:
297:
194:
219:
578:
571:
326:
225:
1956:
29:
55:
1803:
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".
333:
232:
1436:"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
866:
141:
847:
1204:
2025:
1203:
assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of
1292:
2001:
1274:
52:
2020:
319:
1925:
1102:
1109:
296:
1415:
1211:
a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent
1261:
1240:
1257:
218:
193:
1937:
1180:
1359:
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome".
1236:
1183:. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
121:
332:
231:
1471:"Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals"
1994:
325:
224:
911:
165:
129:
1633:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004).
1686:
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells".
892:
1842:"Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells"
1434:
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999).
1598:
Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM (Oct 2004).
1312:"Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis"
1758:
Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT (Sep 2006).
1987:
1646:
1368:
1212:
207:
108:
1943:
1931:
1085:
1081:
1077:
1069:
1048:
1044:
1010:
989:
985:
1828:
1586:
1392:
153:
1760:"Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly"
1073:
1040:
1014:
981:
1906:
1863:
1820:
1791:
1746:
1703:
1674:
1621:
1578:
1543:
1500:
1457:
1384:
1341:
101:
45:
1971:
1896:
1888:
1853:
1812:
1781:
1771:
1736:
1728:
1695:
1664:
1654:
1611:
1568:
1533:
1525:
1490:
1482:
1447:
1376:
1331:
1323:
577:
570:
412:
343:
287:
242:
171:
1600:"Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage"
1208:
387:
149:
1650:
1372:
1901:
1876:
1786:
1759:
1741:
1716:
1538:
1513:
1495:
1470:
1336:
1311:
1669:
1634:
781:
776:
771:
766:
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756:
751:
746:
741:
736:
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715:
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680:
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659:
654:
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644:
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629:
624:
619:
2014:
606:
1832:
1590:
1573:
1556:
1396:
133:
1967:
1192:
405:
184:
1877:"A novel AAK1 splice variant functions at multiple steps of the endocytic pathway"
1858:
1841:
1717:"Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key"
1776:
157:
1297:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1279:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1196:
1639:
Proceedings of the
National Academy of Sciences of the United States of America
488:
304:
201:
137:
1452:
1435:
1892:
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1380:
811:
548:
426:
371:
358:
270:
257:
145:
1910:
1867:
1824:
1795:
1750:
1707:
1678:
1625:
1616:
1599:
1582:
1547:
1504:
1461:
1388:
1345:
1557:"AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin"
1529:
1486:
1327:
1149:
1144:
1200:
1133:
956:
937:
923:
878:
1732:
1699:
78:
74:
28:
1514:"Differential requirements for AP-2 in clathrin-mediated endocytosis"
1169:
1117:
833:
1955:
1816:
1469:
Ricotta D, Conner SD, Schmid SL, von Figura K, Honing S (Mar 2002).
1635:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
796:
792:
1963:
1176:
586:
125:
1721:
American
Journal of Respiratory Cell and Molecular Biology
395:
1975:
560:
1062:
1033:
1003:
974:
531:
dentate gyrus of hippocampal formation granule cell
1253:
1251:
1249:
1232:
1230:
1228:
1215:. Its kinase activity is stimulated by clathrin.
342:
241:
1840:Takahashi T, Furuchi T, Naganuma A (Dec 2006).
16:Protein-coding gene in the species Homo sapiens
1258:GRCm38: Ensembl release 89: ENSMUSG00000057230
762:positive regulation of Notch signaling pathway
1995:
1555:Conner SD, Schröter T, Schmid SL (Dec 2003).
8:
772:regulation of clathrin-dependent endocytosis
1416:"Entrez Gene: AAK1 AP2 associated kinase 1"
1237:GRCh38: Ensembl release 89: ENSG00000115977
2002:
1988:
807:
602:
511:transitional epithelium of urinary bladder
383:
282:
179:
63:
1900:
1857:
1785:
1775:
1740:
1668:
1658:
1615:
1572:
1537:
1494:
1451:
1335:
1410:
1408:
1406:
660:protein serine/threonine kinase activity
1224:
701:extrinsic component of plasma membrane
18:
1195:) functions during receptor-mediated
347:
308:
303:
246:
205:
200:
7:
1952:
1950:
1875:Henderson DM, Conner SD (Jul 2007).
499:vestibular membrane of cochlear duct
1604:The Journal of Biological Chemistry
1191:Adaptor-related protein complex 2 (
1162:Adaptor-associated protein kinase 1
1974:. You can help Knowledge (XXG) by
1059:
1030:
1000:
971:
947:
928:
902:
883:
857:
838:
752:regulation of protein localization
565:
483:
421:
400:
14:
1512:Conner SD, Schmid SL (Sep 2003).
1310:Conner SD, Schmid SL (Mar 2002).
1207:. The protein interacts with and
1172:that in humans is encoded by the
437:lateral nuclear group of thalamus
1954:
576:
569:
469:inferior ganglion of vagus nerve
331:
324:
318:
295:
230:
223:
217:
192:
27:
1574:10.1046/j.1398-9219.2003.0142.x
1166:AP2-associated protein kinase 1
587:More reference expression data
549:More reference expression data
1:
2026:Human chromosome 2 gene stubs
1881:Molecular Biology of the Cell
1859:10.1158/0008-5472.CAN-06-3220
1181:clathrin mediated endocytosis
316:
215:
1777:10.1371/journal.pbio.0040262
1688:Journal of Proteome Research
625:AP-2 adaptor complex binding
2021:Genes on human chromosome 2
1930:human gene location in the
1518:The Journal of Cell Biology
1475:The Journal of Cell Biology
1316:The Journal of Cell Biology
757:protein autophosphorylation
449:superior vestibular nucleus
2042:
1949:
1942:human gene details in the
523:retinal pigment epithelium
1293:"Mouse PubMed Reference:"
1275:"Human PubMed Reference:"
1148:
1143:
1139:
1132:
1116:
1097:
1066:
1037:
1026:
1007:
978:
967:
954:
950:
935:
931:
922:
909:
905:
890:
886:
877:
864:
860:
845:
841:
832:
817:
810:
806:
790:
782:regulation of endocytosis
605:
601:
584:
568:
559:
546:
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
169:
164:
119:
116:
112:, AP2 associated kinase 1
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
1893:10.1091/mbc.E06-09-0831
1715:Collawn JF (Jul 2006).
1660:10.1073/pnas.0404720101
1381:10.1126/science.1075762
1205:Ser/Thr protein kinases
1103:Chr 2: 69.46 – 69.67 Mb
767:protein phosphorylation
706:clathrin-coated vesicle
635:protein kinase activity
1617:10.1074/jbc.M408095200
1453:10.1093/dnares/6.3.197
453:ventral tegmental area
1530:10.1083/jcb.200304069
1487:10.1083/jcb.200111068
1328:10.1083/jcb.200108123
777:membrane organization
747:protein stabilization
535:medial dorsal nucleus
1805:Nature Biotechnology
1213:receptor endocytosis
1110:Chr 6: 86.85 – 87 Mb
620:transferase activity
349:6 D1|6 37.75 cM
310:Chromosome 6 (mouse)
208:Chromosome 2 (human)
67:List of PDB id codes
40:Available structures
1944:UCSC Genome Browser
1932:UCSC Genome Browser
1651:2004PNAS..10112130B
1373:2002Sci...298.1912M
1179:and is involved in
696:clathrin-coated pit
1962:This article on a
912:ENSMUSG00000057230
730:Biological process
669:Cellular component
630:nucleotide binding
613:Molecular function
1983:
1982:
1733:10.1165/rcmb.f317
1700:10.1021/pr050048h
1610:(44): 46191–203.
1367:(5600): 1912–34.
1159:
1158:
1155:
1154:
1128:
1127:
1093:
1092:
1056:
1055:
1022:
1021:
997:
996:
963:
962:
944:
943:
918:
917:
899:
898:
873:
872:
854:
853:
802:
801:
691:cell leading edge
597:
596:
593:
592:
555:
554:
542:
541:
480:
479:
378:
377:
277:
276:
90:
89:
86:
85:
50:Ortholog search:
2033:
2004:
1997:
1990:
1958:
1951:
1914:
1904:
1871:
1861:
1836:
1799:
1789:
1779:
1754:
1744:
1711:
1682:
1672:
1662:
1629:
1619:
1594:
1576:
1551:
1541:
1508:
1498:
1465:
1455:
1420:
1419:
1412:
1401:
1400:
1356:
1350:
1349:
1339:
1307:
1301:
1300:
1289:
1283:
1282:
1271:
1265:
1255:
1244:
1234:
1141:
1140:
1112:
1105:
1088:
1060:
1051:
1031:
1027:RefSeq (protein)
1017:
1001:
992:
972:
948:
929:
903:
884:
858:
839:
808:
603:
589:
580:
573:
566:
551:
503:substantia nigra
491:
489:Top expressed in
484:
461:Brodmann area 23
429:
427:Top expressed in
422:
401:
384:
374:
361:
350:
335:
328:
322:
311:
299:
283:
273:
260:
249:
234:
227:
221:
210:
196:
180:
174:
160:
158:AAK1 - orthologs
111:
104:
81:
64:
58:
37:
36:
31:
19:
2041:
2040:
2036:
2035:
2034:
2032:
2031:
2030:
2011:
2010:
2009:
2008:
1922:
1917:
1887:(7): 2698–706.
1874:
1852:(24): 11932–7.
1846:Cancer Research
1839:
1817:10.1038/nbt1240
1811:(10): 1285–92.
1802:
1757:
1714:
1685:
1645:(33): 12130–5.
1632:
1597:
1554:
1511:
1468:
1433:
1429:
1427:Further reading
1424:
1423:
1414:
1413:
1404:
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1290:
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1256:
1247:
1235:
1226:
1221:
1189:
1150:View/Edit Mouse
1145:View/Edit Human
1108:
1101:
1098:Location (UCSC)
1084:
1080:
1076:
1072:
1068:
1047:
1043:
1039:
1013:
1009:
988:
984:
980:
893:ENSG00000115977
786:
742:phosphorylation
725:
686:terminal bouton
681:plasma membrane
664:
650:protein binding
645:kinase activity
585:
575:
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538:
533:
529:
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286:Gene location (
268:
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183:Gene location (
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100:
73:
51:
17:
12:
11:
5:
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2037:
2029:
2028:
2023:
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2012:
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1999:
1992:
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1980:
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1920:External links
1918:
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1712:
1694:(4): 1339–46.
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1567:(12): 885–90.
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1446:(3): 197–205.
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1421:
1402:
1351:
1302:
1284:
1266:
1245:
1223:
1222:
1220:
1217:
1209:phosphorylates
1193:AP-2 complexes
1188:
1185:
1164:also known as
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1137:
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1130:
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527:pontine nuclei
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388:RNA expression
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1411:
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1398:
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1386:
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1378:
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1202:
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1186:
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1167:
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1042:
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1025:
1018:
1016:
1012:
1006:
1002:
999:
993:
991:
987:
983:
977:
973:
970:
968:RefSeq (mRNA)
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
914:
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729:
728:
722:
719:
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689:
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684:
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679:
677:
674:
673:
671:
668:
667:
661:
658:
656:
653:
651:
648:
646:
643:
641:
640:Notch binding
638:
636:
633:
631:
628:
626:
623:
621:
618:
617:
615:
612:
611:
608:
607:Gene ontology
604:
600:
588:
583:
579:
572:
567:
564:
562:
558:
550:
545:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
473:parietal lobe
472:
468:
464:
460:
456:
452:
448:
444:
441:renal medulla
440:
436:
435:
432:
428:
423:
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389:
385:
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98:
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82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1976:expanding it
1968:chromosome 2
1961:
1938:
1926:
1884:
1880:
1849:
1845:
1808:
1804:
1767:
1764:PLOS Biology
1763:
1724:
1720:
1691:
1687:
1642:
1638:
1607:
1603:
1564:
1560:
1524:(5): 773–9.
1521:
1517:
1481:(5): 791–5.
1478:
1474:
1443:
1440:DNA Research
1439:
1364:
1360:
1354:
1322:(5): 921–9.
1319:
1315:
1305:
1296:
1287:
1278:
1269:
1190:
1173:
1165:
1161:
1160:
1086:NP_001365584
1082:NP_001365583
1078:NP_001365581
1070:NP_001035195
1067:
1049:NP_001358506
1045:NP_001358504
1038:
1011:NM_001040106
1008:
990:NM_001371577
986:NM_001371575
979:
955:
936:
910:
891:
865:
846:
826:
821:
515:ciliary body
411:
404:
117:External IDs
72:
1770:(9): e262.
1199:to trigger
1197:endocytosis
737:endocytosis
655:ATP binding
507:Paneth cell
370:87,003,223
357:86,849,517
269:69,674,349
256:69,457,997
95:Identifiers
2015:Categories
1727:(1): 1–2.
1264:, May 2017
1243:, May 2017
1219:References
415:(ortholog)
138:HomoloGene
1966:on human
1074:NP_808430
1041:NP_055726
1015:NM_177762
982:NM_014911
812:Orthologs
711:cytoplasm
519:subiculum
166:EC number
146:GeneCards
1911:17494869
1868:17178891
1833:14294292
1825:16964243
1796:16903783
1751:16782842
1708:16083285
1679:15302935
1626:15292237
1591:84066885
1583:14617351
1548:12952931
1505:11877457
1462:10470851
1397:26554314
1389:12471243
1346:11877461
1260:–
1239:–
1201:clathrin
1187:Function
1134:Wikidata
791:Sources:
676:membrane
172:2.7.11.1
1902:1924820
1787:1540706
1742:2658690
1647:Bibcode
1561:Traffic
1539:2172816
1496:2173304
1369:Bibcode
1361:Science
1337:2173317
1262:Ensembl
1241:Ensembl
924:UniProt
879:Ensembl
818:Species
797:QuickGO
721:nucleus
716:cytosol
465:pylorus
390:pattern
134:1098687
102:Aliases
1909:
1899:
1866:
1831:
1823:
1794:
1784:
1749:
1739:
1706:
1677:
1670:514446
1667:
1624:
1589:
1581:
1546:
1536:
1503:
1493:
1460:
1395:
1387:
1344:
1334:
1170:enzyme
1168:is an
1120:search
1118:PubMed
957:Q3UHJ0
938:Q2M2I8
867:269774
834:Entrez
561:BioGPS
457:cardia
248:2p13.3
142:128746
126:616405
1970:is a
1829:S2CID
1587:S2CID
1393:S2CID
848:22848
827:Mouse
822:Human
793:Amigo
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
185:Human
1972:stub
1964:gene
1939:AAK1
1927:AAK1
1907:PMID
1864:PMID
1821:PMID
1792:PMID
1747:PMID
1704:PMID
1675:PMID
1622:PMID
1579:PMID
1544:PMID
1501:PMID
1458:PMID
1385:PMID
1342:PMID
1177:gene
1174:AAK1
445:pons
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
150:AAK1
122:OMIM
109:AAK1
79:5L4Q
75:4WSQ
56:RCSB
53:PDBe
22:AAK1
1897:PMC
1889:doi
1854:doi
1813:doi
1782:PMC
1772:doi
1737:PMC
1729:doi
1696:doi
1665:PMC
1655:doi
1643:101
1612:doi
1608:279
1569:doi
1534:PMC
1526:doi
1522:162
1491:PMC
1483:doi
1479:156
1448:doi
1377:doi
1365:298
1332:PMC
1324:doi
1320:156
366:End
265:End
154:OMA
130:MGI
46:PDB
2017::
1905:.
1895:.
1885:18
1883:.
1879:.
1862:.
1850:66
1848:.
1844:.
1827:.
1819:.
1809:24
1807:.
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1723:.
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1559:.
1542:.
1532:.
1520:.
1516:.
1499:.
1489:.
1477:.
1473:.
1456:.
1442:.
1438:.
1405:^
1391:.
1383:.
1375:.
1363:.
1340:.
1330:.
1318:.
1314:.
1295:.
1277:.
1248:^
1227:^
795:/
372:bp
359:bp
271:bp
258:bp
152:;
148::
144:;
140::
136:;
132::
128:;
124::
77:,
2003:e
1996:t
1989:v
1978:.
1946:.
1934:.
1913:.
1891::
1870:.
1856::
1835:.
1815::
1798:.
1774::
1768:4
1753:.
1731::
1710:.
1698::
1692:4
1681:.
1657::
1649::
1628:.
1614::
1593:.
1571::
1565:4
1550:.
1528::
1507:.
1485::
1464:.
1450::
1444:6
1418:.
1399:.
1379::
1371::
1348:.
1326::
1299:.
1281:.
290:)
187:)
156::
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