256:
233:
130:
155:
1411:. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate (
507:
262:
161:
2769:
1655:
Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes".
1415:
activity). The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
2326:
Eloranta ML, Heiskanen JT, Hiltunen MJ, et al. (2003). "Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alpha gene polymorphisms in
Finnish women with obstetric cholestasis".
2297:
Eloranta ML, Heiskanen JT, Hiltunen MJ, et al. (2003). "Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alpha gene polymorphisms in
Finnish women with obstetric cholestasis".
2034:
Smit JJ, Schinkel AH, Oude
Elferink RP, et al. (1993). "Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease".
2167:
Malorni W, Lucia MB, Rainaldi G, et al. (1998). "Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients".
2599:
269:
168:
1439:
at different levels of malignancy. For this reason, ABCB4 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
2513:
2188:
Jacquemin E, Cresteil D, Manouvrier S, et al. (1999). "Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy".
1393:
2418:
77:
1095:
1076:
2574:
2838:
2814:
1527:
1397:
2396:
1509:
2833:
2073:"MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine"
2227:"Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking"
1447:
2442:
255:
2749:
2372:
1440:
1436:
1925:
Smit JJ, Mol CA, van
Deemter L, et al. (1995). "Characterization of the promoter region of the human MDR3 P-glycoprotein gene".
1311:
2260:
Jacquemin E (2002). "Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases".
232:
1318:
1638:
1408:
1867:
Callen DF, Baker E, Simmers RN, et al. (1987). "Localization of the human multiple drug resistance gene, MDR1, to 7q21.1".
1496:
1475:
2411:
1492:
1450:, high gamma glutamyl transferase intrahepatic cholestasis of pregnancy, chronic cholangiopathy and adult biliary fibrosis.
2384:
154:
129:
1471:
57:
1547:"The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver"
268:
167:
1838:
van der Bliek AM, Kooiman PM, Schneider C, Borst P (1989). "Sequence of mdr3 cDNA encoding a human P-glycoprotein".
2435:
261:
160:
2807:
2404:
2366:
1140:
101:
65:
1121:
1904:
Smit JJ, Schinkel AH, Mol CA, et al. (1994). "Tissue distribution of the human MDR3 P-glycoprotein".
2604:
1545:
Van der Bliek AM, Baas F, Ten Houte de Lange T, Kooiman PM, Van der Velde-Koerts T, Borst P (Mar 1988).
2800:
2127:
1596:"MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis"
1428:
143:
2390:
2378:
1997:
Ruetz S, Gros P (1994). "Phosphatidylcholine translocase: a physiological role for the mdr2 gene".
1770:"MDR3 mutations associated with intrahepatic and gallbladder cholesterol cholelithiasis: an update"
2362:
44:
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2102:
2059:
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1985:
1892:
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89:
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1239:
1218:
1214:
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48:, ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3, ATP binding cassette subfamily B member 4
2343:
2314:
2277:
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2205:
2176:
2155:
2094:
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2014:
1977:
1942:
1913:
1884:
1855:
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1791:
1756:
1725:"Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene"
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85:
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107:
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1708:
Sticova E, Jirsa M (2019) ABCB4 disease: Many faces of one gene deficiency. Ann
Hepatol
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558:
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548:
2827:
2150:
2115:
2047:
2010:
1972:
1955:
1938:
1851:
535:
2289:
2217:
2063:
2026:
1989:
1956:"Clinical and biochemical findings in progressive familial intrahepatic cholestasis"
1896:
1695:
2780:
341:
120:
69:
2106:
93:
2116:"Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis"
1532:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1514:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2120:
Proceedings of the
National Academy of Sciences of the United States of America
1446:
Other conditions that have been associated with mutations in this gene include
424:
1805:"Structure of the human MDR3 gene and physical mapping of the human MDR locus"
240:
137:
73:
1612:
1595:
1040:
484:
362:
307:
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193:
81:
2347:
2318:
2281:
2252:
2243:
2226:
1795:
1760:
1741:
1687:
1639:"Entrez Gene: ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4"
1621:
2209:
2180:
2159:
2140:
2098:
2055:
2018:
1981:
1946:
1917:
1888:
1859:
1830:
1580:
1358:
1353:
2727:
2273:
1678:
1432:
1412:
1342:
1185:
1166:
1880:
1404:
1152:
1107:
1669:
2628:
2623:
2618:
2553:
2492:
2487:
1326:
1062:
2768:
2735:
2731:
2722:
2717:
2712:
2696:
2691:
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2659:
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2608:
2594:
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2584:
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2538:
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2482:
2477:
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2457:
1025:
1021:
2776:
2522:
2517:
1381:
61:
2400:
515:
1803:
Lincke CR, Smit JJ, van der Velde-Koerts T, Borst P (1991).
1768:
Mbongo-Kama E, Harnois F, Mennecier D, et al. (2007).
1954:
Whitington PF, Freese DK, Alonso EM, et al. (1994).
2225:
Dixon PH, Weerasekera N, Linton KJ, et al. (2000).
2071:
van
Helvoort A, Smith AJ, Sprong H, et al. (1996).
331:
2788:
1407:
encoded by this gene is a member of the superfamily of
2114:
de Vree JM, Jacquemin E, Sturm E, et al. (1998).
1427:
gene has been observed progressively downregulated in
496:
2705:
2684:
2668:
2637:
2562:
2501:
2450:
1448:
low phospholipid associated cholelithiasis syndrome
1287:
1258:
1232:
1203:
1488:
1486:
1484:
1467:
1465:
1463:
726:positive regulation of phospholipid translocation
549:ATPase-coupled transmembrane transporter activity
278:
177:
986:xenobiotic transport across blood-brain barrier
1650:
1648:
1594:Rosmorduc O, Hermelin B, Poupon R (Apr 2001).
1493:GRCm38: Ensembl release 89: ENSMUSG00000042476
2808:
2412:
1394:progressive familial intrahepatic cholestasis
896:cellular response to external biotic stimulus
741:positive regulation of phospholipid transport
8:
916:cellular response to organic cyclic compound
721:positive regulation of cholesterol transport
1472:GRCh38: Ensembl release 89: ENSG00000005471
931:cellular response to dexamethasone stimulus
2815:
2801:
2419:
2405:
2397:
1036:
531:
319:
218:
115:
2365:at the U.S. National Library of Medicine
2242:
2149:
2139:
2088:
1971:
1820:
1785:
1750:
1740:
1677:
1611:
1570:
1633:
1631:
564:phosphatidylcholine transporter activity
559:ABC-type xenobiotic transporter activity
1459:
1409:ATP-binding cassette (ABC) transporters
996:positive regulation of response to drug
921:cellular hyperosmotic salinity response
911:cellular response to estradiol stimulus
991:establishment of blood-retinal barrier
18:
2328:Eur. J. Obstet. Gynecol. Reprod. Biol
2299:Eur. J. Obstet. Gynecol. Reprod. Biol
1398:intrahepatic cholestasis of pregnancy
1001:regulation of lipid metabolic process
635:integral component of plasma membrane
569:phosphatidylcholine floppase activity
283:
244:
239:
182:
141:
136:
7:
2765:
2763:
891:establishment of blood-brain barrier
1006:regulation of intestinal absorption
816:response to organic cyclic compound
2787:. You can help Knowledge (XXG) by
1563:10.1002/j.1460-2075.1987.tb02653.x
1284:
1255:
1229:
1200:
1176:
1157:
1131:
1112:
1086:
1067:
851:maintenance of blood-brain barrier
731:xenobiotic transmembrane transport
501:
419:
357:
336:
14:
1729:Orphanet Journal of Rare Diseases
886:negative regulation of cell death
821:response to isoquinoline alkaloid
594:phospholipid transporter activity
2767:
1973:10.1097/00005176-199402000-00003
966:cellular response to L-glutamate
941:response to antineoplastic agent
505:
447:extensor digitorum longus muscle
267:
260:
254:
231:
166:
159:
153:
128:
1960:J. Pediatr. Gastroenterol. Nutr
901:cellular response to antibiotic
1723:Rosmorduc O, Poupon R (2007).
1435:derived from uterine cervical
1386:multidrug resistance protein 3
856:cellular response to mycotoxin
716:cellular response to bile acid
620:integral component of membrane
516:More reference expression data
485:More reference expression data
1:
2839:Human chromosome 7 gene stubs
2340:10.1016/s0301-2115(02)00160-4
2311:10.1016/S0301-2115(02)00064-7
2202:10.1016/S0140-6736(05)77221-4
2090:10.1016/S0092-8674(00)81370-7
1822:10.1016/S0021-9258(19)67788-4
1787:10.1016/S1665-2681(19)31919-2
906:cellular response to alkaloid
806:response to organic substance
252:
151:
16:Protein-coding gene in humans
2048:10.1016/0092-8674(93)90380-9
2011:10.1016/0092-8674(94)90446-4
1939:10.1016/0167-4781(94)00214-n
1852:10.1016/0378-1119(88)90057-1
961:cellular response to borneol
2834:Genes on human chromosome 7
2436:membrane transport proteins
2377:human gene location in the
826:response to nutrient levels
2855:
2762:
2389:human gene details in the
771:phospholipid translocation
599:ceramide floppase activity
2750:ABC transporter disorders
2745:
1528:"Mouse PubMed Reference:"
1510:"Human PubMed Reference:"
1357:
1352:
1348:
1341:
1325:
1306:
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1236:
1207:
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1119:
1115:
1106:
1093:
1089:
1074:
1070:
1061:
1046:
1039:
1035:
1019:
981:response to cyclosporin A
926:response to dexamethasone
640:intercellular canaliculus
534:
530:
513:
504:
495:
482:
431:
422:
369:
360:
330:
322:
318:
301:
288:
251:
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187:
150:
127:
118:
114:
105:
100:
55:
52:
42:
35:
30:
26:
21:
2367:Medical Subject Headings
1433:neoplastic keratinocytes
1403:The membrane-associated
439:tibialis anterior muscle
1613:10.1053/gast.2001.23947
951:response to L-glutamate
876:response to cadmium ion
756:transmembrane transport
746:response to fenofibrate
665:clathrin-coated vesicle
443:vastus lateralis muscle
1927:Biochim. Biophys. Acta
1742:10.1186/1750-1172-2-29
1372:ATP-binding cassette 4
1312:Chr 7: 87.4 – 87.48 Mb
946:ceramide translocation
861:daunorubicin transport
645:apical plasma membrane
471:triceps brachii muscle
2141:10.1073/pnas.95.1.282
1441:preneoplastic lesions
1437:preneoplastic lesions
1319:Chr 5: 8.94 – 9.01 Mb
976:response to quercetin
956:response to glycoside
936:response to thyroxine
881:intestinal absorption
846:response to vitamin D
836:response to vitamin A
831:response to estradiol
811:response to mycotoxin
690:brush border membrane
655:extracellular exosome
2363:ABCB4+protein,+human
2274:10.1055/s-2001-19033
2244:10.1093/hmg/9.8.1209
1774:Annals of Hepatology
1429:human papillomavirus
866:response to morphine
781:placenta development
751:xenobiotic transport
463:gastrocnemius muscle
397:right adrenal cortex
246:Chromosome 5 (mouse)
144:Chromosome 7 (human)
2391:UCSC Genome Browser
2379:UCSC Genome Browser
2132:1998PNAS...95..282D
1392:is associated with
971:response to codeine
841:carbohydrate export
776:response to hypoxia
766:bile acid secretion
695:apical part of cell
660:cytoplasmic vesicle
401:left adrenal cortex
389:right adrenal gland
373:right lobe of liver
285:5 A1|5 3.43 cM
2775:This article on a
1881:10.1007/BF00272381
1141:ENSMUSG00000042476
704:Biological process
685:actin cytoskeleton
608:Cellular component
584:hydrolase activity
554:nucleotide binding
542:Molecular function
455:tibiofemoral joint
435:left lobe of liver
393:left adrenal gland
381:buccal mucosa cell
2796:
2795:
2757:
2756:
2428:Membrane proteins
1670:10.1002/jcp.24808
1368:
1367:
1364:
1363:
1337:
1336:
1302:
1301:
1281:
1280:
1247:
1246:
1226:
1225:
1192:
1191:
1173:
1172:
1147:
1146:
1128:
1127:
1102:
1101:
1083:
1082:
1031:
1030:
871:xenobiotic export
801:hormone transport
786:brain development
761:lipid homeostasis
526:
525:
522:
521:
491:
490:
478:
477:
416:
415:
314:
313:
213:
212:
94:ABCB4 - orthologs
2846:
2817:
2810:
2803:
2771:
2764:
2432:carrier proteins
2421:
2414:
2407:
2398:
2351:
2322:
2293:
2262:Semin. Liver Dis
2256:
2246:
2221:
2184:
2163:
2153:
2143:
2110:
2092:
2067:
2030:
1993:
1975:
1950:
1921:
1900:
1863:
1834:
1824:
1799:
1789:
1764:
1754:
1744:
1709:
1706:
1700:
1699:
1681:
1652:
1643:
1642:
1635:
1626:
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1615:
1600:Gastroenterology
1591:
1585:
1584:
1574:
1551:The EMBO Journal
1542:
1536:
1535:
1524:
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1517:
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1500:
1490:
1479:
1469:
1350:
1349:
1321:
1314:
1297:
1285:
1276:
1256:
1252:RefSeq (protein)
1242:
1230:
1221:
1201:
1177:
1158:
1132:
1113:
1087:
1068:
1037:
796:circadian rhythm
736:lipid metabolism
532:
518:
509:
502:
487:
451:plantaris muscle
427:
425:Top expressed in
420:
377:secondary oocyte
365:
363:Top expressed in
358:
337:
320:
310:
297:
286:
271:
264:
258:
247:
235:
219:
209:
196:
185:
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116:
110:
96:
47:
40:
19:
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2844:
2843:
2824:
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2822:
2821:
2760:
2758:
2753:
2741:
2701:
2680:
2664:
2633:
2558:
2497:
2446:
2439:ABC transporter
2425:
2359:
2354:
2325:
2296:
2259:
2231:Hum. Mol. Genet
2224:
2196:(9148): 210–1.
2187:
2166:
2113:
2070:
2033:
1996:
1953:
1924:
1903:
1866:
1837:
1802:
1767:
1722:
1718:
1716:Further reading
1713:
1712:
1707:
1703:
1654:
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1646:
1637:
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1629:
1593:
1592:
1588:
1557:(11): 3325–31.
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1521:
1508:
1507:
1503:
1491:
1482:
1470:
1461:
1456:
1422:
1359:View/Edit Mouse
1354:View/Edit Human
1317:
1310:
1307:Location (UCSC)
1293:
1272:
1268:
1264:
1238:
1217:
1213:
1209:
1122:ENSG00000005471
1015:
711:lipid transport
699:
630:plasma membrane
603:
579:protein binding
574:ATPase activity
514:
483:
474:
469:
467:muscle of thigh
465:
461:
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391:
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222:Gene location (
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119:Gene location (
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36:
17:
12:
11:
5:
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2357:External links
2355:
2353:
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2323:
2294:
2257:
2237:(8): 1209–17.
2222:
2185:
2164:
2111:
2068:
2031:
2005:(7): 1071–81.
1994:
1951:
1922:
1901:
1864:
1835:
1815:(8): 5303–10.
1800:
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1719:
1717:
1714:
1711:
1710:
1701:
1664:(4): 802–812.
1658:J Cell Physiol
1644:
1627:
1606:(6): 1459–67.
1586:
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1455:
1452:
1421:
1418:
1366:
1365:
1362:
1361:
1356:
1346:
1345:
1339:
1338:
1335:
1334:
1332:
1330:
1323:
1322:
1315:
1308:
1304:
1303:
1300:
1299:
1289:
1288:
1282:
1279:
1278:
1260:
1259:
1253:
1249:
1248:
1245:
1244:
1234:
1233:
1227:
1224:
1223:
1205:
1204:
1198:
1194:
1193:
1190:
1189:
1181:
1180:
1174:
1171:
1170:
1162:
1161:
1155:
1149:
1148:
1145:
1144:
1136:
1135:
1129:
1126:
1125:
1117:
1116:
1110:
1104:
1103:
1100:
1099:
1091:
1090:
1084:
1081:
1080:
1072:
1071:
1065:
1059:
1058:
1053:
1048:
1044:
1043:
1033:
1032:
1029:
1028:
1017:
1016:
1014:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
707:
705:
701:
700:
698:
697:
692:
687:
682:
680:focal adhesion
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
611:
609:
605:
604:
602:
601:
596:
591:
586:
581:
576:
571:
566:
561:
556:
551:
545:
543:
539:
538:
528:
527:
524:
523:
520:
519:
511:
510:
499:
493:
492:
489:
488:
480:
479:
476:
475:
473:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
429:
428:
417:
414:
413:
411:
410:
406:
405:biceps brachii
402:
398:
394:
390:
386:
382:
378:
374:
370:
367:
366:
354:
353:
345:
334:
328:
327:
324:RNA expression
316:
315:
312:
311:
303:
299:
298:
290:
287:
282:
276:
275:
266:
259:
253:
249:
248:
243:
237:
236:
228:
227:
215:
214:
211:
210:
202:
198:
197:
189:
186:
181:
175:
174:
165:
158:
152:
148:
147:
140:
134:
133:
125:
124:
112:
111:
104:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2851:
2840:
2837:
2835:
2832:
2831:
2829:
2818:
2813:
2811:
2806:
2804:
2799:
2798:
2792:
2790:
2786:
2782:
2778:
2773:
2770:
2766:
2761:
2752:
2751:
2744:
2737:
2733:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2710:
2708:
2704:
2698:
2695:
2693:
2690:
2689:
2687:
2683:
2677:
2674:
2673:
2671:
2667:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2642:
2640:
2636:
2630:
2627:
2625:
2622:
2620:
2617:
2614:
2610:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2567:
2565:
2561:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2524:
2521:
2519:
2515:
2512:
2510:
2507:
2506:
2504:
2500:
2494:
2491:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2464:
2461:
2459:
2456:
2455:
2453:
2449:
2444:
2440:
2437:
2433:
2429:
2422:
2417:
2415:
2410:
2408:
2403:
2402:
2399:
2392:
2388:
2387:
2383:
2380:
2376:
2375:
2371:
2368:
2364:
2361:
2360:
2356:
2349:
2345:
2341:
2337:
2333:
2329:
2324:
2320:
2316:
2312:
2308:
2305:(2): 109–12.
2304:
2300:
2295:
2291:
2287:
2283:
2279:
2275:
2271:
2268:(4): 551–62.
2267:
2263:
2258:
2254:
2250:
2245:
2240:
2236:
2232:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2186:
2182:
2178:
2174:
2170:
2169:Haematologica
2165:
2161:
2157:
2152:
2147:
2142:
2137:
2133:
2129:
2125:
2121:
2117:
2112:
2108:
2104:
2100:
2096:
2091:
2086:
2083:(3): 507–17.
2082:
2078:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2045:
2042:(3): 451–62.
2041:
2037:
2032:
2028:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1995:
1991:
1987:
1983:
1979:
1974:
1969:
1966:(2): 134–41.
1965:
1961:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1923:
1919:
1915:
1912:(5): 638–49.
1911:
1907:
1902:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1865:
1861:
1857:
1853:
1849:
1846:(2): 401–11.
1845:
1841:
1836:
1832:
1828:
1823:
1818:
1814:
1810:
1809:J. Biol. Chem
1806:
1801:
1797:
1793:
1788:
1783:
1779:
1775:
1771:
1766:
1762:
1758:
1753:
1748:
1743:
1738:
1734:
1730:
1726:
1721:
1720:
1715:
1705:
1702:
1697:
1693:
1689:
1685:
1680:
1679:11392/2066612
1675:
1671:
1667:
1663:
1659:
1651:
1649:
1645:
1640:
1634:
1632:
1628:
1623:
1619:
1614:
1609:
1605:
1601:
1597:
1590:
1587:
1582:
1578:
1573:
1568:
1564:
1560:
1556:
1552:
1548:
1541:
1538:
1533:
1529:
1523:
1520:
1515:
1511:
1505:
1502:
1498:
1494:
1489:
1487:
1485:
1481:
1477:
1473:
1468:
1466:
1464:
1460:
1453:
1451:
1449:
1444:
1443:progression.
1442:
1438:
1434:
1430:
1426:
1419:
1417:
1414:
1410:
1406:
1401:
1399:
1395:
1391:
1387:
1383:
1379:
1378:
1373:
1360:
1355:
1351:
1347:
1344:
1340:
1333:
1331:
1328:
1324:
1320:
1316:
1313:
1309:
1305:
1298:
1296:
1290:
1286:
1283:
1277:
1275:
1271:
1267:
1261:
1257:
1254:
1250:
1243:
1241:
1235:
1231:
1228:
1222:
1220:
1216:
1212:
1206:
1202:
1199:
1197:RefSeq (mRNA)
1195:
1188:
1187:
1182:
1178:
1175:
1169:
1168:
1163:
1159:
1156:
1154:
1150:
1143:
1142:
1137:
1133:
1130:
1124:
1123:
1118:
1114:
1111:
1109:
1105:
1098:
1097:
1092:
1088:
1085:
1079:
1078:
1073:
1069:
1066:
1064:
1060:
1057:
1054:
1052:
1049:
1045:
1042:
1038:
1034:
1027:
1023:
1018:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
708:
706:
703:
702:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
650:membrane raft
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
612:
610:
607:
606:
600:
597:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
503:
500:
498:
494:
486:
481:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
433:
430:
426:
421:
418:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
371:
368:
364:
359:
356:
355:
352:
350:
346:
344:
343:
339:
338:
335:
333:
329:
325:
321:
317:
309:
304:
300:
296:
291:
281:
277:
270:
263:
257:
250:
242:
238:
234:
229:
225:
220:
216:
208:
203:
199:
195:
190:
180:
176:
169:
162:
156:
149:
145:
139:
135:
131:
126:
122:
117:
113:
109:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2789:expanding it
2781:chromosome 7
2774:
2759:
2747:
2528:
2385:
2373:
2334:(2): 132–5.
2331:
2327:
2302:
2298:
2265:
2261:
2234:
2230:
2193:
2189:
2175:(1): 13–20.
2172:
2168:
2126:(1): 282–7.
2123:
2119:
2080:
2076:
2039:
2035:
2002:
1998:
1963:
1959:
1933:(1): 44–56.
1930:
1926:
1909:
1905:
1875:(2): 142–4.
1872:
1868:
1843:
1839:
1812:
1808:
1780:(3): 143–9.
1777:
1773:
1732:
1728:
1704:
1661:
1657:
1603:
1599:
1589:
1554:
1550:
1540:
1531:
1522:
1513:
1504:
1445:
1424:
1423:
1402:
1389:
1385:
1376:
1375:
1371:
1369:
1292:
1263:
1237:
1208:
1184:
1165:
1139:
1120:
1094:
1075:
1055:
1050:
347:
340:
53:External IDs
1906:Lab. Invest
1396:type 3 and
670:nucleoplasm
589:ATP binding
205:87,480,435
192:87,401,696
31:Identifiers
2828:Categories
1869:Hum. Genet
1499:, May 2017
1478:, May 2017
1454:References
1431:-positive
351:(ortholog)
306:9,009,231
293:8,943,717
74:HomoloGene
2779:on human
2748:see also
1295:NP_032856
1274:NP_061338
1270:NP_061337
1266:NP_000434
1240:NM_008830
1219:NM_018850
1215:NM_018849
1211:NM_000443
1041:Orthologs
1011:transport
791:lactation
615:cytoplasm
102:EC number
82:GeneCards
2728:Sterolin
2348:12381474
2319:12206920
2290:28265904
2282:11745043
2253:10767346
2218:31374153
2064:29083916
2027:35251756
1990:41477311
1897:40453462
1796:17786139
1761:17562004
1696:24986454
1688:25205602
1622:11313316
1495:–
1474:–
1413:flippase
1384:encodes
1343:Wikidata
1020:Sources:
625:membrane
385:testicle
2210:9923886
2181:9542318
2160:9419367
2128:Bibcode
2099:8898203
2056:8106172
2019:7912658
1982:7912266
1947:7893760
1918:7734012
1889:3477522
1860:2906314
1831:2002063
1752:1910597
1581:2892668
1497:Ensembl
1476:Ensembl
1405:protein
1153:UniProt
1108:Ensembl
1047:Species
1026:QuickGO
675:cytosol
326:pattern
184:7q21.12
108:7.6.2.2
38:Aliases
2443:TC 3A1
2369:(MeSH)
2346:
2317:
2288:
2280:
2251:
2216:
2208:
2190:Lancet
2179:
2158:
2148:
2105:
2097:
2062:
2054:
2025:
2017:
1988:
1980:
1945:
1916:
1895:
1887:
1858:
1829:
1794:
1759:
1749:
1735:: 29.
1694:
1686:
1620:
1579:
1572:553787
1569:
1420:Cancer
1329:search
1327:PubMed
1186:P21440
1167:P21439
1063:Entrez
497:BioGPS
409:spleen
78:136368
62:171060
2783:is a
2386:ABCB4
2374:ABCB4
2286:S2CID
2214:S2CID
2151:18201
2107:16488
2103:S2CID
2060:S2CID
2023:S2CID
1986:S2CID
1893:S2CID
1692:S2CID
1425:ABCB4
1390:ABCB4
1377:ABCB4
1096:18670
1056:Mouse
1051:Human
1022:Amigo
459:ankle
349:Mouse
342:Human
289:Start
224:Mouse
188:Start
121:Human
86:ABCB4
70:97569
45:ABCB4
22:ABCB4
2785:stub
2777:gene
2605:C8-9
2514:B2-3
2344:PMID
2315:PMID
2278:PMID
2249:PMID
2206:PMID
2177:PMID
2156:PMID
2095:PMID
2077:Cell
2052:PMID
2036:Cell
2015:PMID
1999:Cell
1978:PMID
1943:PMID
1931:1261
1914:PMID
1885:PMID
1856:PMID
1840:Gene
1827:PMID
1792:PMID
1757:PMID
1684:PMID
1618:PMID
1577:PMID
1382:gene
1370:The
1077:5244
332:Bgee
280:Band
241:Chr.
179:Band
138:Chr.
58:OMIM
2629:C13
2624:C11
2619:C10
2554:B11
2493:A13
2488:A12
2336:doi
2332:105
2307:doi
2303:104
2270:doi
2239:doi
2198:doi
2194:353
2146:PMC
2136:doi
2085:doi
2044:doi
2007:doi
1968:doi
1935:doi
1877:doi
1848:doi
1817:doi
1813:266
1782:doi
1747:PMC
1737:doi
1674:hdl
1666:doi
1662:230
1608:doi
1604:120
1567:PMC
1559:doi
302:End
201:End
90:OMA
66:MGI
2830::
2736:G8
2734:,
2732:G5
2723:G4
2718:G2
2713:G1
2697:F2
2692:F1
2676:E1
2660:D4
2655:D3
2650:D2
2645:D1
2613:C9
2611:,
2609:C8
2600:C7
2595:C6
2590:C5
2585:C4
2580:C3
2575:C2
2570:C1
2549:B9
2544:B7
2539:B6
2534:B5
2529:B4
2523:B3
2518:B2
2509:B1
2483:A8
2478:A7
2473:A4
2468:A3
2463:A2
2458:A1
2434::
2430:,
2342:.
2330:.
2313:.
2301:.
2284:.
2276:.
2266:21
2264:.
2247:.
2233:.
2229:.
2212:.
2204:.
2192:.
2173:83
2171:.
2154:.
2144:.
2134:.
2124:95
2122:.
2118:.
2101:.
2093:.
2081:87
2079:.
2075:.
2058:.
2050:.
2040:75
2038:.
2021:.
2013:.
2003:77
2001:.
1984:.
1976:.
1964:18
1962:.
1958:.
1941:.
1929:.
1910:71
1908:.
1891:.
1883:.
1873:77
1871:.
1854:.
1844:71
1842:.
1825:.
1811:.
1807:.
1790:.
1776:.
1772:.
1755:.
1745:.
1731:.
1727:.
1690:.
1682:.
1672:.
1660:.
1647:^
1630:^
1616:.
1602:.
1598:.
1575:.
1565:.
1553:.
1549:.
1530:.
1512:.
1483:^
1462:^
1400:.
1388:.
1380:)
1024:/
308:bp
295:bp
207:bp
194:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2816:e
2809:t
2802:v
2791:.
2738:)
2730:(
2706:G
2685:F
2669:E
2638:D
2615:)
2607:(
2563:C
2525:)
2516:(
2502:B
2451:A
2445:)
2441:(
2420:e
2413:t
2406:v
2393:.
2381:.
2350:.
2338::
2321:.
2309::
2292:.
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