536:
5958:
513:
5598:
5763:
410:
435:
5583:
5868:
5643:
5553:
5778:
5853:
5613:
5538:
5913:
787:
5748:
5658:
5628:
5838:
5823:
5808:
5793:
5568:
5883:
5718:
5703:
5688:
5673:
5733:
542:
441:
5943:
5898:
5928:
2140:
7268:
4802:
Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B (April 1999). "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene
63:
5957:
5009:
Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M (June 2008). "Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression".
3126:
Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF (May 1997). "Interaction between ATM protein and c-Abl in response to DNA damage".
5597:
2578:
Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides".
3399:
Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON (July 1991). "BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner".
5762:
5222:
Keung YK, Beaty M, Steward W, Jackle B, Pettnati M (2002). "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature".
5429:
3718:"Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)"
5582:
4974:
Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (August 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation".
2649:
Takizawa Y, Kinebuchi T, Kagawa W, Yokoyama S, Shibata T, Kurumizaka H (September 2004). "Mutational analyses of the human Rad51-Tyr315 residue, a site for phosphorylation in leukaemia cells".
5867:
5642:
4336:
Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D (June 1999). "p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage".
4894:"Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton"
5552:
4840:"ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks"
5777:
4714:"The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes"
5852:
2050:. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the
4205:"Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae"
4440:"The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity"
5612:
549:
448:
2958:
Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in
Alzheimer's disease".
4636:
Miyamura T, Nishimura J, Yufu Y, Nawata H (February 1997). "Interaction of BCR-ABL with the retinoblastoma protein in
Philadelphia chromosome-positive cell lines".
5537:
6413:
5912:
5747:
5657:
5627:
4025:"Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase"
5837:
5822:
5807:
5792:
5567:
5966:: Crystal structure of the N114A mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions
5882:
5717:
5702:
5687:
5672:
5416:
4156:"Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes"
6837:
5998:
1725:
4023:
Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (April 2000).
357:
3939:
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL".
1706:
6710:
6136:
5732:
4293:
Yano H, Cong F, Birge RB, Goff SP, Chao MV (February 2000). "Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor".
6451:
6093:
5517:
5350:
5204:
2560:
2915:
Biesova Z, Piccoli C, Wong WT (January 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth".
7288:
6121:
5606:: CRYSTAL STRUCTURE OF THE ABL-SH3 DOMAIN COMPLEXED WITH A DESIGNED HIGH-AFFINITY PEPTIDE LIGAND: IMPLICATIONS FOR SH3-LIGAND INTERACTIONS
2542:
6489:
6480:
6180:
6175:
6170:
6165:
5385:
3855:
Yu HH, Zisch AH, Dodelet VC, Pasquale EB (July 2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor".
3372:
Ling X, Ma G, Sun T, Liu J, Arlinghaus RB (January 2003). "Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr".
4306:
2823:
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL (July 2004). "Overriding imatinib resistance with a novel ABL kinase inhibitor".
1965:
535:
6374:
6365:
4548:"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation"
5942:
5897:
5435:
2131:
gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2–11.
6987:
6156:
4066:"The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr"
2222:
2144:
1972:
5927:
4387:
Agami R, Blandino G, Oren M, Shaul Y (June 1999). "Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis".
512:
6059:
4254:"Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop"
3081:
Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gasser PJ, Park MS, Sung P,
2809:
2529:
2508:
5991:
5425:
5150:
Era T (2002). "Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells".
4673:"A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle"
2174:, encodes an unregulated, cytoplasm-targeted tyrosine kinase that allows the cells to proliferate without being regulated by
7143:
3224:"p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene"
2525:
434:
409:
328:, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
60:
6204:
5441:
3984:"Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains"
3759:"Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells"
3039:"Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity"
2329:
2263:
2051:
7258:
2504:
6635:
6567:
6558:
2159:
337:
5771:: Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
6941:
6932:
6868:
6696:
5420:
2237:
2210:
6912:
548:
447:
6379:
5078:
Shore SK, Tantravahi RV, Reddy EP (December 2002). "Transforming pathways activated by the v-Abl tyrosine kinase".
7128:
4933:
Bassermann F, Jahn T, Miething C, Seipel P, Bai RY, Coutinho S, Tybulewicz VL, Peschel C, Duyster J (April 2002).
7293:
7244:
7231:
7218:
7205:
7192:
7179:
7166:
5984:
5510:
2163:
541:
440:
7138:
3222:
Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996).
7092:
7035:
6029:
6015:
5399:
5379:
2694:"BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP"
1770:
381:
345:
7040:
6753:
6744:
2998:"Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response"
2190:
2094:
1751:
4105:
Goldberg Z, Vogt Sionov R, Berger M, Zwang Y, Perets R, Van Etten RA, Oren M, Taya Y, Haupt Y (July 2002).
3758:
6042:
5591:: THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES
3443:
Foray N, Marot D, Randrianarison V, Venezia ND, Picard D, Perricaudet M, Favaudon V, Jeggo P (June 2002).
2622:
Abelson HT, Rabstein LS (August 1970). "Lymphosarcoma: virus-induced thymic-independent disease in mice".
2401:
5876:: Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor
5651:: Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy
7061:
6980:
6705:
6389:
7133:
5561:: CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE
5503:
4935:"Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway"
4500:
4396:
4345:
3276:
3136:
2832:
2588:
2194:
2116:
423:
4755:"c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein"
2876:"Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase"
2735:"Targeting DNA Homologous Repair Proficiency With Concomitant Topoisomerase II and c-Abl Inhibition"
7097:
6403:
5447:
1944:
1940:
1936:
1932:
1881:
1877:
1873:
1865:
5395:
4892:
Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (May 1998).
324:
7030:
6787:
6777:
6768:
6596:
6587:
5276:
5175:
5103:
4420:
4369:
4318:
3964:
3880:
3837:
3757:
van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von
Lindern M (November 2000).
3425:
3323:
Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T (February 1994).
3302:
3160:
2940:
2856:
2674:
369:
5976:
3445:"Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation"
3183:"Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks"
1948:
1911:
1907:
1869:
1844:
1840:
6821:
5475:
5454:
5356:
5346:
5334:
5325:
5311:
5268:
5239:
5210:
5200:
5167:
5138:
5095:
5056:
5037:
4991:
4956:
4915:
4871:
4820:
4784:
4735:
4694:
4653:
4618:
4569:
4528:
4469:
4412:
4361:
4310:
4275:
4234:
4185:
4136:
4087:
4046:
4005:
3956:
3921:
3872:
3829:
3788:
3739:
3698:
3657:
3611:
3559:
3515:
3474:
3417:
3381:
3354:
3294:
3245:
3204:
3152:
3108:
3060:
3019:
2975:
2932:
2897:
2848:
2766:
2715:
2666:
2631:
2604:
2431:
2119:. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by
317:
53:
4589:"c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage"
7076:
7071:
7045:
6973:
6098:
6084:
5786:: Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
5338:
5301:
5260:
5231:
5192:
5159:
5128:
5087:
5048:
5027:
5019:
4983:
4946:
4905:
4861:
4851:
4812:
4774:
4766:
4725:
4684:
4645:
4608:
4600:
4559:
4518:
4508:
4459:
4451:
4404:
4353:
4302:
4265:
4224:
4216:
4175:
4167:
4126:
4118:
4077:
4036:
3995:
3948:
3911:
3864:
3819:
3778:
3770:
3729:
3688:
3647:
3636:"Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites"
3601:
3593:
3549:
3505:
3464:
3456:
3409:
3344:
3336:
3284:
3235:
3194:
3144:
3098:
3087:"Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl"
3082:
3050:
3009:
2967:
2924:
2887:
2840:
2756:
2746:
2705:
2658:
2596:
2469:
786:
628:
559:
503:
458:
6345:
3808:"Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok"
387:
7123:
7107:
7020:
6686:
6355:
6340:
6330:
6325:
6305:
6300:
6295:
6290:
6285:
6276:
6011:
3716:
Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (November 1998).
3538:"Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor"
3265:"Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases"
2311:
2213:. The BCR-ABL protein can be inhibited by various small molecules. One such inhibitor is
2202:
2124:
2070:
603:
365:
5861:: X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain
5375:
5187:
Pendergast AM (2002). "The Abl family kinases: mechanisms of regulation and signaling".
4504:
4400:
4349:
3280:
3140:
2836:
2592:
7272:
7161:
7102:
6816:
6811:
6806:
6190:
6007:
5326:"Regulation for Nuclear Targeting of the Abl Tyrosine Kinase in Response to DNA Damage"
4180:
4155:
3606:
3581:
3340:
2761:
2734:
5235:
5196:
4779:
4754:
4649:
4613:
4588:
4564:
4547:
4464:
4439:
4270:
4253:
4229:
4204:
4131:
4106:
3824:
3807:
3469:
3444:
3349:
3324:
3289:
3264:
2971:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
7282:
7066:
7025:
6252:
6113:
5484:
5463:
5405:
4689:
4672:
4604:
4523:
4489:"Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK"
4488:
3460:
3413:
2662:
2359:
2078:
2074:
815:
5280:
5179:
5107:
4322:
4064:
Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M (December 1997).
3968:
3884:
3841:
3306:
2944:
2874:
Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003).
2860:
2678:
2217:, which occupies the tyrosine kinase domain and inhibits BCR-ABL's influence on the
7015:
6797:
6508:
6499:
6243:
5621:: CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
5333:. Advances in Experimental Medicine and Biology. Vol. 604. Springer. pp.
4424:
4373:
3429:
3164:
2733:
Siddiqui A, Tumiati M, Joko A, Sandholm J, Roering P, Aakko S, et al. (2021).
2139:
2047:
621:
400:
4546:
Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (December 2000).
3675:
Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997).
3494:"Catalase activity is regulated by c-Abl and Arg in the oxidative stress response"
349:
5342:
3734:
3717:
373:
7239:
7174:
7010:
5052:
4154:
Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C (October 1996).
3325:"Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway"
2565:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2547:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2112:
2098:
7267:
5251:
Saglio G, Cilloni D (2004). "Abl: the prototype of oncogenic fusion proteins".
2468:
There is some evidence that the expression of Abl is regulated by the microRNA
704:
6922:
6917:
6907:
6902:
6893:
6842:
6758:
5264:
5023:
3774:
3677:"Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation"
2293:
2218:
2206:
2086:
2082:
520:
417:
353:
4910:
4893:
4866:
4856:
4839:
4816:
4513:
4252:
Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T (March 2000).
4082:
4065:
4041:
4024:
3900:"Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases"
3240:
3223:
3103:
3086:
2751:
2225:
are also under development to inhibit BCR-ABL mutants resistant to imatinib.
7213:
7187:
5546:: THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL
4107:"Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation"
3693:
3676:
2844:
2710:
2693:
2600:
2179:
2175:
2147:
1670:
764:
642:
587:
574:
486:
473:
361:
5360:
5315:
5272:
5243:
5214:
5171:
5142:
5133:
5116:
5099:
5091:
5060:
5041:
4995:
4960:
4951:
4934:
4824:
4770:
4730:
4713:
4622:
4573:
4532:
4455:
4416:
4365:
4314:
4279:
4171:
4140:
4122:
4050:
4000:
3983:
3952:
3925:
3916:
3899:
3876:
3868:
3792:
3615:
3563:
3554:
3537:
3519:
3510:
3493:
3478:
3385:
3208:
3199:
3182:
3112:
3023:
3014:
2997:
2979:
2928:
2901:
2892:
2875:
2852:
2770:
2719:
2670:
5306:
5289:
4919:
4875:
4788:
4739:
4698:
4657:
4473:
4307:
10.1002/(SICI)1097-4547(20000201)59:3<356::AID-JNR9>3.0.CO;2-G
4238:
4220:
4189:
4091:
4009:
3960:
3833:
3743:
3702:
3661:
3421:
3358:
3298:
3249:
3156:
3064:
3055:
3038:
2936:
2810:"Entrez Gene: ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1"
2692:
Salles D, Mencalha AL, Ireno IC, WiesmĂĽller L, Abdelhay E (January 2011).
2635:
2608:
2012:
2007:
1271:
positive regulation of Wnt signaling pathway, planar cell polarity pathway
6657:
6064:
5921:: Abl kinase domain unligated and in complex with tetrahydrostaurosporine
4987:
3982:
Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (January 1997).
3181:
Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP (August 2001).
2784:
2481:
2287:
2275:
2214:
2198:
2103:
2090:
2066:
1996:
1815:
1796:
4487:
Roig J, Tuazon PT, Zipfel PA, Pendergast AM, Traugh JA (December 2000).
4203:
Law SF, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis EA (July 1996).
3652:
3635:
3536:
Miyoshi-Akiyama T, Aleman LM, Smith JM, Adler CE, Mayer BJ (July 2001).
1611:
positive regulation of cell migration involved in sprouting angiogenesis
5756:: Crystal structure of the c-Abl kinase domain in complex with INNO-406
5666:: Crystal Structure of the c-Abl Kinase domain in complex with PD173955
5636:: CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
5489:
5479:
5468:
5458:
5163:
3597:
2383:
2032:
1782:
1737:
5032:
1311:
positive regulation of release of sequestered calcium ion into cytosol
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
7226:
6996:
6946:
6209:
6145:
6140:
3783:
3582:"Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl"
3148:
2455:
2437:
2425:
1980:
1692:
5846:: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
5831:: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
5816:: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
5801:: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
5576:: CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN
17:
5891:: Human Abl kinase domain in complex with imatinib (STI571, Glivec)
5726:: Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl
5711:: Structural basis for the auto-inhibition of c-Abl tyrosine kinase
5696:: Structural basis for the auto-inhibition of c-Abl tyrosine kinase
5681:: Structural basis for the auto-inhibition of c-Abl tyrosine kinase
7200:
6734:
6612:
6577:
6572:
6548:
6350:
6335:
6320:
6315:
6310:
6262:
6257:
6233:
6228:
6219:
6131:
6126:
6103:
6074:
6069:
4408:
4357:
2443:
2395:
2389:
2353:
2323:
2281:
2269:
2138:
1616:
positive regulation of substrate adhesion-dependent cell spreading
1655:
1651:
6852:
6782:
6729:
6720:
6681:
6672:
6662:
6543:
6534:
6524:
6470:
6461:
6446:
6437:
6427:
6422:
6398:
6199:
6051:
5389:
2449:
2419:
2413:
2407:
2377:
2371:
2347:
2341:
2335:
2317:
2305:
2299:
2257:
2251:
2245:
2167:
2143:
ABL1 kinase domain (blue) in complex with the second-generation
2120:
2039:
341:
6969:
6633:
6027:
5980:
5499:
2073:
that has been implicated in processes of cell differentiation,
1356:
negative regulation of protein serine/threonine kinase activity
1151:
intrinsic apoptotic signaling pathway in response to DNA damage
6883:
6878:
6873:
6847:
5495:
3580:
Soubeyran P, Barac A, Szymkiewicz I, Dikic I (February 2003).
2365:
1166:
platelet-derived growth factor receptor-beta signaling pathway
1436:
negative regulation of ubiquitin-protein transferase activity
795:
5474:
Overview of all the structural information available in the
5453:
Overview of all the structural information available in the
1211:
Fc-gamma receptor signaling pathway involved in phagocytosis
2085:. Activity of ABL1 protein is negatively regulated by its
6965:
5741:: SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE
1456:
positive regulation of I-kappaB kinase/NF-kappaB signaling
1406:
positive regulation of cytosolic calcium ion concentration
1316:
negative regulation of I-kappaB kinase/NF-kappaB signaling
1020:
extrinsic component of cytoplasmic side of plasma membrane
4803:(SHC) in chronic myelogenous leukemia progenitor cells".
1586:
positive regulation of transcription by RNA polymerase II
1276:
platelet-derived growth factor receptor signaling pathway
1186:
negative regulation of endothelial cell apoptotic process
1641:
positive regulation of actin cytoskeleton reorganization
1256:
positive regulation of peptidyl-tyrosine phosphorylation
611:
3898:
Cao C, Leng Y, Huang W, Liu X, Kufe D (October 2003).
1621:
negative regulation of long-term synaptic potentiation
874:
non-membrane spanning protein tyrosine kinase activity
7256:
1626:
regulation of hematopoietic stem cell differentiation
776:
2089:, and deletion of the SH3 domain turns ABL1 into an
7152:
7116:
7085:
7054:
7003:
6931:
6892:
6861:
6830:
6796:
6767:
6743:
6719:
6695:
6671:
6647:
6605:
6586:
6557:
6533:
6517:
6498:
6479:
6460:
6436:
6412:
6388:
6364:
6275:
6242:
6218:
6189:
6155:
6112:
6083:
6050:
6041:
1925:
1900:
1858:
1833:
5324:
4587:Yoshida K, Komatsu K, Wang HG, Kufe D (May 2002).
2521:
2519:
2517:
2500:
2498:
2496:
2127:, suggesting a cell cycle function for ABL1. The
1206:epidermal growth factor receptor signaling pathway
1121:positive regulation of muscle cell differentiation
869:nicotinate-nucleotide adenylyltransferase activity
5290:"Role of c-Abl in the DNA damage stress response"
2185:This gene is a partner in a fusion gene with the
1556:positive regulation of endothelial cell migration
558:
457:
1631:regulation of modification of synaptic structure
1396:B cell proliferation involved in immune response
3575:
3573:
3531:
3529:
3176:
3174:
3076:
3074:
2991:
2989:
2162:(CML). In CML, the gene is activated by being
1566:regulation of Cdc42 protein signal transduction
1451:regulation of extracellular matrix organization
1371:positive regulation of osteoblast proliferation
1226:negative regulation of phospholipase C activity
1196:regulation of actin cytoskeleton reorganization
5951:: Abl kinase domain in complex with NVP-AFG210
5906:: Abl kinase domain in complex with NVP-AEG082
4887:
4885:
3629:
3627:
3625:
3318:
3316:
2526:GRCm38: Ensembl release 89: ENSMUSG00000026842
1601:positive regulation of focal adhesion assembly
1306:positive regulation of oxidoreductase activity
1101:positive regulation of protein phosphorylation
6981:
5992:
5511:
1636:positive regulation of blood vessel branching
1466:transitional one stage B cell differentiation
1301:signal transduction in response to DNA damage
1291:regulation of actin cytoskeleton organization
1261:regulation of response to DNA damage stimulus
1171:positive regulation of actin filament binding
984:sequence-specific double-stranded DNA binding
8:
5936:: Abl kinase domain in complex with PD180970
5488:(Mouse Tyrosine-protein kinase ABL1) at the
5467:(Human Tyrosine-protein kinase ABL1) at the
1596:positive regulation of stress fiber assembly
1461:negative regulation of ERK1 and ERK2 cascade
1421:negative regulation of BMP signaling pathway
1156:positive regulation of ERK1 and ERK2 cascade
2505:GRCh38: Ensembl release 89: ENSG00000097007
2178:. This, in turn, allows the cell to become
2166:within the BCR (breakpoint cluster region)
1536:regulation of cell population proliferation
1161:substrate adhesion-dependent cell spreading
6988:
6974:
6966:
6644:
6630:
6047:
6038:
6024:
5999:
5985:
5977:
5518:
5504:
5496:
2996:Cao C, Leng Y, Li C, Kufe D (April 2003).
2193:, a characteristic abnormality in chronic
2069:encodes a cytoplasmic and nuclear protein
1666:
1366:negative regulation of cellular senescence
1326:positive regulation of microtubule binding
1201:regulation of transcription, DNA-templated
1146:DNA damage induced protein phosphorylation
811:
599:
498:
395:
71:
5398:at the U.S. National Library of Medicine
5378:at the U.S. National Library of Medicine
5305:
5132:
5031:
4950:
4909:
4865:
4855:
4838:Wang B, Golemis EA, Kruh GD (July 1997).
4778:
4729:
4688:
4612:
4563:
4522:
4512:
4463:
4269:
4228:
4179:
4130:
4081:
4040:
3999:
3915:
3823:
3806:Yamanashi Y, Baltimore D (January 1997).
3782:
3733:
3692:
3651:
3605:
3553:
3509:
3468:
3348:
3288:
3263:Mayer BJ, Hirai H, Sakai R (March 1995).
3239:
3198:
3102:
3054:
3013:
2891:
2760:
2750:
2709:
2170:on chromosome 22. This new fusion gene,
1496:negative regulation of mitotic cell cycle
1391:negative regulation of cell-cell adhesion
1231:positive regulation of mitotic cell cycle
1116:neuromuscular process controlling balance
27:Human protein-coding gene on chromosome 9
3634:Ren R, Ye ZS, Baltimore D (April 1994).
2201:forms. The BCR-ABL transcript encodes a
1446:positive regulation of apoptotic process
1141:regulation of microtubule polymerization
1126:cellular response to DNA damage stimulus
934:mitogen-activated protein kinase binding
7263:
5533:
5117:"c-Abl: activation and nuclear targets"
2492:
2209:regulation system, leading to a clonal
1491:cellular response to lipopolysaccharide
1286:activation of protein kinase C activity
3037:Dai Z, Pendergast AM (November 1995).
1501:cellular response to hydrogen peroxide
31:
5189:Advances in Cancer Research Volume 85
4438:Wen ST, Van Etten RA (October 1997).
3492:Cao C, Leng Y, Kufe D (August 2003).
1531:cellular response to oxidative stress
1341:peptidyl-tyrosine autophosphorylation
1216:establishment of protein localization
563:
524:
519:
462:
421:
416:
7:
1581:regulation of T cell differentiation
1546:neuroepithelial cell differentiation
747:vestibular membrane of cochlear duct
5386:Online Mendelian Inheritance in Man
4671:Welch PJ, Wang JY (November 1993).
2205:, which activates mediators of the
2035:that, in humans, is encoded by the
1551:integrin-mediated signaling pathway
1476:Bergmann glial cell differentiation
1411:positive regulation of neuron death
3341:10.1002/j.1460-2075.1994.tb06319.x
2223:BCR-ABL tyrosine-kinase inhibitors
1922:
1897:
1855:
1830:
1806:
1787:
1761:
1742:
1716:
1697:
959:transcription coactivator activity
781:
699:
637:
616:
25:
5191:. Vol. 85. pp. 51–100.
4753:Zhu J, Shore SK (December 1996).
2785:"UniProtKB - P00519 (ABL1_HUMAN)"
2145:Bcr-Abl tyrosine-kinase inhibitor
2115:present in many cases of chronic
1591:T cell receptor signaling pathway
1481:peptidyl-tyrosine phosphorylation
1351:regulation of cellular senescence
1346:alpha-beta T cell differentiation
1176:B cell receptor signaling pathway
7266:
5956:
5941:
5926:
5911:
5896:
5881:
5866:
5851:
5836:
5821:
5806:
5791:
5776:
5761:
5746:
5731:
5716:
5701:
5686:
5671:
5656:
5641:
5626:
5611:
5596:
5581:
5566:
5551:
5536:
5288:Shaul Y, Ben-Yehoyada M (2005).
4605:10.1128/MCB.22.10.3292-3300.2002
3461:10.1128/MCB.22.12.4020-4032.2002
2663:10.1111/j.1365-2443.2004.00772.x
939:protein tyrosine kinase activity
785:
547:
540:
534:
511:
446:
439:
433:
408:
4712:Agami R, Shaul Y (April 1998).
2197:(CML) and rarely in some other
1361:actin cytoskeleton organization
1035:perinuclear region of cytoplasm
954:phosphotyrosine residue binding
834:protein domain specific binding
5430:Atlas of Genetics and Oncology
5331:Advances in Molecular Oncology
2081:, and stress response such as
1381:activated T cell proliferation
796:More reference expression data
765:More reference expression data
1:
6636:Non-receptor tyrosine kinases
5236:10.1016/S0165-4608(02)00609-X
5197:10.1016/S0065-230X(02)85003-5
4650:10.1016/S0925-5710(96)00539-7
4565:10.1016/S1097-2765(00)00138-6
4271:10.1016/S0014-5793(00)01242-4
3825:10.1016/S0092-8674(00)81841-3
3290:10.1016/S0960-9822(95)00060-1
2972:10.1016/S0378-1119(01)00521-2
2052:Abelson murine leukemia virus
1401:cellular response to dopamine
944:four-way junction DNA binding
665:muscle layer of sigmoid colon
532:
431:
5343:10.1007/978-0-387-69116-9_15
4690:10.1016/0092-8674(93)90497-E
4493:Proc. Natl. Acad. Sci. U.S.A
3735:10.4049/jimmunol.161.10.5555
3414:10.1016/0092-8674(91)90148-R
2160:chronic myelogenous leukemia
2097:results in the head-to-tail
2025:Tyrosine-protein kinase ABL1
1571:neuropilin signaling pathway
1266:mitochondrial depolarization
1246:response to oxidative stress
1111:regulation of axon extension
7289:Genes on human chromosome 9
5053:10.1016/j.ccell.2016.03.013
2211:myeloproliferative disorder
1541:protein autophosphorylation
1321:regulation of cell motility
1136:regulation of cell adhesion
884:proline-rich region binding
673:stromal cell of endometrium
657:paraflocculus of cerebellum
7310:
5446:gene details page in the
1576:endothelial cell migration
1521:post-embryonic development
1075:protein-containing complex
854:signaling receptor binding
849:protein C-terminus binding
7144:Michaelis–Menten kinetics
6643:
6629:
6037:
6030:Receptor tyrosine kinases
6023:
5531:
5265:10.1007/s00018-004-4271-0
5024:10.1016/j.ccr.2008.04.018
3775:10.1182/blood.V96.10.3406
2561:"Mouse PubMed Reference:"
2543:"Human PubMed Reference:"
2158:gene are associated with
2011:
2006:
2002:
1995:
1979:
1966:Chr 9: 130.71 – 130.89 Mb
1960:
1929:
1904:
1893:
1862:
1837:
1826:
1813:
1809:
1794:
1790:
1781:
1768:
1764:
1749:
1745:
1736:
1723:
1719:
1704:
1700:
1691:
1676:
1669:
1665:
1649:
1281:regulation of endocytosis
814:
810:
793:
784:
775:
762:
711:
702:
649:
640:
610:
602:
598:
581:
568:
531:
510:
501:
497:
480:
467:
430:
407:
398:
394:
385:
380:
335:
332:
322:
315:
310:
79:
74:
57:
52:
47:
43:
39:
34:
7036:Diffusion-limited enzyme
5400:Medical Subject Headings
5380:Medical Subject Headings
4911:10.1074/jbc.273.22.13681
4857:10.1074/jbc.272.28.17542
4817:10.1182/blood.V93.8.2707
4514:10.1073/pnas.97.26.14346
4083:10.1074/jbc.272.52.33260
4042:10.1074/jbc.275.15.10779
3241:10.1074/jbc.271.41.25198
3104:10.1074/jbc.274.18.12748
2752:10.3389/fonc.2021.733700
1416:regulation of cell cycle
1236:actin filament branching
1191:cerebellum morphogenesis
914:protein kinase C binding
6043:Growth factor receptors
5419:Info with links in the
5224:Cancer Genet. Cytogenet
3694:10.1182/blood.V89.1.297
2845:10.1126/science.1099480
2601:10.1126/science.1857987
2236:gene has been shown to
2191:Philadelphia chromosome
1973:Chr 2: 31.58 – 31.69 Mb
1606:DNA conformation change
1336:regulation of autophagy
1131:protein phosphorylation
979:supercoiled DNA binding
974:ephrin receptor binding
864:protein kinase activity
719:internal carotid artery
715:external carotid artery
5421:Cell Migration Gateway
5396:Abelson+Leukemia+Virus
5134:10.1038/sj.cdd.4400626
5092:10.1038/sj.onc.1206084
4952:10.1074/jbc.M112397200
4771:10.1128/mcb.16.12.7054
4731:10.1038/sj.onc.1201708
4456:10.1101/gad.11.19.2456
4172:10.1084/jem.184.4.1365
4001:10.1074/jbc.272.5.2659
3953:10.1038/sj.onc.1202024
3917:10.1074/jbc.M305770200
3869:10.1038/sj.onc.1204524
3555:10.1038/sj.onc.1204528
3511:10.1074/jbc.M301292200
3200:10.1074/jbc.M011534200
3015:10.1074/jbc.M300058200
2929:10.1038/sj.onc.1200822
2893:10.1074/jbc.M301447200
2151:
1526:neuron differentiation
1511:innate immune response
1106:B-1 B cell homeostasis
899:actin filament binding
7129:Eadie–Hofstee diagram
7062:Allosteric regulation
5412:- The Interactive Fly
5307:10.1038/sj.cr.7290261
4221:10.1128/mcb.16.7.3327
3056:10.1101/gad.9.21.2569
2739:Frontiers in Oncology
2711:10.1093/carcin/bgq216
2142:
2135:Clinical significance
2095:t(9;22) translocation
929:manganese ion binding
889:magnesium ion binding
829:actin monomer binding
7139:Lineweaver–Burk plot
6114:PDGF receptor family
5440:genome location and
4123:10.1093/emboj/cdf384
2221:. Second generation
2195:myelogenous leukemia
2117:myelogenous leukemia
2111:genes, leading to a
1561:cell differentiation
1486:collateral sprouting
1431:B cell proliferation
894:transferase activity
661:middle frontal gyrus
526:Chromosome 2 (mouse)
424:Chromosome 9 (human)
75:List of PDB id codes
48:Available structures
6518:ROS receptor family
6052:EGF receptor family
5448:UCSC Genome Browser
5410:Abl tyrosine kinase
5253:Cell. Mol. Life Sci
4505:2000PNAS...9714346R
4401:1999Natur.399..809A
4350:1999Natur.399..814Y
3653:10.1101/gad.8.7.783
3281:1995CBio....5..296M
3141:1997Natur.387R.520S
2837:2004Sci...305..399S
2593:1991Sci...253..562S
1516:neural tube closure
1471:DNA mismatch repair
1441:microspike assembly
743:endocardial cushion
689:ganglionic eminence
565:2 21.86 cM|2 B
7098:Enzyme superfamily
7031:Enzyme promiscuity
5323:Yoshida K (2007).
5164:10.1007/BF02982716
4988:10.1093/hmg/ddh167
3598:10.1042/BJ20021539
2152:
1771:ENSMUSG00000026842
1376:mitotic cell cycle
1241:spleen development
1221:thymus development
1094:Biological process
1080:neuronal cell body
1030:actin cytoskeleton
993:Cellular component
969:SH2 domain binding
964:neuropilin binding
949:bubble DNA binding
924:nucleotide binding
839:SH3 domain binding
822:Molecular function
7254:
7253:
6963:
6962:
6959:
6958:
6955:
6954:
6625:
6624:
6621:
6620:
6271:
6270:
5974:
5973:
5352:978-0-387-69114-5
5206:978-0-12-006685-8
5121:Cell Death Differ
4867:20.500.12613/9174
3863:(30): 3995–4006.
3234:(41): 25198–203.
2831:(5682): 399–401.
2215:imatinib mesylate
2154:Mutations in the
2042:(previous symbol
2022:
2021:
2018:
2017:
1991:
1990:
1956:
1955:
1919:
1918:
1889:
1888:
1852:
1851:
1822:
1821:
1803:
1802:
1777:
1776:
1758:
1757:
1732:
1731:
1713:
1712:
1661:
1660:
1181:apoptotic process
1060:cell leading edge
879:metal ion binding
806:
805:
802:
801:
771:
770:
758:
757:
696:
695:
677:left uterine tube
594:
593:
493:
492:
306:
305:
302:
301:
58:Ortholog search:
16:(Redirected from
7301:
7294:Tyrosine kinases
7271:
7270:
7262:
7134:Hanes–Woolf plot
7077:Enzyme activator
7072:Enzyme inhibitor
7046:Enzyme catalysis
6990:
6983:
6976:
6967:
6645:
6631:
6085:Insulin receptor
6048:
6039:
6025:
6012:tyrosine kinases
6001:
5994:
5987:
5978:
5960:
5945:
5930:
5915:
5900:
5885:
5870:
5855:
5840:
5825:
5810:
5795:
5780:
5765:
5750:
5735:
5720:
5705:
5690:
5675:
5660:
5645:
5630:
5615:
5600:
5585:
5570:
5555:
5540:
5520:
5513:
5506:
5497:
5364:
5328:
5319:
5309:
5284:
5259:(23): 2897–911.
5247:
5218:
5183:
5146:
5136:
5115:Shaul Y (2000).
5111:
5065:
5064:
5045:
5035:
5006:
5000:
4999:
4971:
4965:
4964:
4954:
4945:(14): 12437–45.
4930:
4924:
4923:
4913:
4904:(22): 13681–92.
4889:
4880:
4879:
4869:
4859:
4850:(28): 17542–50.
4835:
4829:
4828:
4799:
4793:
4792:
4782:
4750:
4744:
4743:
4733:
4709:
4703:
4702:
4692:
4668:
4662:
4661:
4633:
4627:
4626:
4616:
4599:(10): 3292–300.
4584:
4578:
4577:
4567:
4543:
4537:
4536:
4526:
4516:
4499:(26): 14346–51.
4484:
4478:
4477:
4467:
4435:
4429:
4428:
4395:(6738): 809–13.
4384:
4378:
4377:
4333:
4327:
4326:
4295:J. Neurosci. Res
4290:
4284:
4283:
4273:
4249:
4243:
4242:
4232:
4200:
4194:
4193:
4183:
4151:
4145:
4144:
4134:
4102:
4096:
4095:
4085:
4076:(52): 33260–70.
4061:
4055:
4054:
4044:
4035:(15): 10779–87.
4020:
4014:
4013:
4003:
3979:
3973:
3972:
3936:
3930:
3929:
3919:
3910:(41): 39609–14.
3895:
3889:
3888:
3852:
3846:
3845:
3827:
3803:
3797:
3796:
3786:
3754:
3748:
3747:
3737:
3713:
3707:
3706:
3696:
3672:
3666:
3665:
3655:
3631:
3620:
3619:
3609:
3577:
3568:
3567:
3557:
3533:
3524:
3523:
3513:
3504:(32): 29667–75.
3489:
3483:
3482:
3472:
3440:
3434:
3433:
3396:
3390:
3389:
3369:
3363:
3362:
3352:
3320:
3311:
3310:
3292:
3260:
3254:
3253:
3243:
3219:
3213:
3212:
3202:
3193:(31): 29282–91.
3178:
3169:
3168:
3149:10.1038/387520a0
3123:
3117:
3116:
3106:
3097:(18): 12748–52.
3078:
3069:
3068:
3058:
3034:
3028:
3027:
3017:
2993:
2984:
2983:
2955:
2949:
2948:
2912:
2906:
2905:
2895:
2886:(24): 21685–92.
2871:
2865:
2864:
2820:
2814:
2813:
2806:
2800:
2799:
2797:
2795:
2781:
2775:
2774:
2764:
2754:
2730:
2724:
2723:
2713:
2689:
2683:
2682:
2646:
2640:
2639:
2619:
2613:
2612:
2575:
2569:
2568:
2557:
2551:
2550:
2539:
2533:
2523:
2512:
2502:
2004:
2003:
1975:
1968:
1951:
1923:
1914:
1898:
1894:RefSeq (protein)
1884:
1856:
1847:
1831:
1807:
1788:
1762:
1743:
1717:
1698:
1667:
1010:nuclear membrane
909:syntaxin binding
812:
798:
789:
782:
767:
751:ventricular zone
727:genital tubercle
707:
705:Top expressed in
700:
681:ventricular zone
645:
643:Top expressed in
638:
617:
600:
590:
577:
566:
551:
544:
538:
527:
515:
499:
489:
476:
465:
450:
443:
437:
426:
412:
396:
390:
376:
374:ABL1 - orthologs
327:
320:
297:
72:
66:
45:
44:
32:
21:
7309:
7308:
7304:
7303:
7302:
7300:
7299:
7298:
7279:
7278:
7277:
7265:
7257:
7255:
7250:
7162:Oxidoreductases
7148:
7124:Enzyme kinetics
7112:
7108:List of enzymes
7081:
7050:
7021:Catalytic triad
6999:
6994:
6964:
6951:
6927:
6888:
6857:
6826:
6792:
6763:
6739:
6715:
6691:
6667:
6639:
6617:
6601:
6582:
6553:
6529:
6513:
6494:
6475:
6456:
6432:
6408:
6384:
6360:
6267:
6238:
6214:
6185:
6151:
6108:
6079:
6033:
6019:
6008:Protein kinases
6005:
5975:
5970:
5967:
5961:
5952:
5946:
5937:
5931:
5922:
5916:
5907:
5901:
5892:
5886:
5877:
5871:
5862:
5856:
5847:
5841:
5832:
5826:
5817:
5811:
5802:
5796:
5787:
5781:
5772:
5766:
5757:
5751:
5742:
5736:
5727:
5721:
5712:
5706:
5697:
5691:
5682:
5676:
5667:
5661:
5652:
5646:
5637:
5631:
5622:
5616:
5607:
5601:
5592:
5586:
5577:
5571:
5562:
5556:
5547:
5541:
5527:
5524:
5372:
5367:
5353:
5322:
5287:
5250:
5221:
5207:
5186:
5152:Int. J. Hematol
5149:
5114:
5086:(56): 8568–76.
5077:
5073:
5071:Further reading
5068:
5047:(Erratum:
5046:
5008:
5007:
5003:
4982:(15): 1535–49.
4976:Hum. Mol. Genet
4973:
4972:
4968:
4932:
4931:
4927:
4891:
4890:
4883:
4837:
4836:
4832:
4801:
4800:
4796:
4765:(12): 7054–62.
4759:Mol. Cell. Biol
4752:
4751:
4747:
4724:(14): 1779–88.
4711:
4710:
4706:
4670:
4669:
4665:
4638:Int. J. Hematol
4635:
4634:
4630:
4593:Mol. Cell. Biol
4586:
4585:
4581:
4545:
4544:
4540:
4486:
4485:
4481:
4450:(19): 2456–67.
4437:
4436:
4432:
4386:
4385:
4381:
4344:(6738): 814–7.
4335:
4334:
4330:
4292:
4291:
4287:
4251:
4250:
4246:
4209:Mol. Cell. Biol
4202:
4201:
4197:
4153:
4152:
4148:
4117:(14): 3715–27.
4104:
4103:
4099:
4063:
4062:
4058:
4022:
4021:
4017:
3981:
3980:
3976:
3938:
3937:
3933:
3897:
3896:
3892:
3854:
3853:
3849:
3805:
3804:
3800:
3769:(10): 3406–13.
3756:
3755:
3751:
3728:(10): 5555–63.
3715:
3714:
3710:
3674:
3673:
3669:
3633:
3632:
3623:
3592:(Pt 1): 29–34.
3579:
3578:
3571:
3548:(30): 4058–69.
3535:
3534:
3527:
3491:
3490:
3486:
3455:(12): 4020–32.
3449:Mol. Cell. Biol
3442:
3441:
3437:
3398:
3397:
3393:
3371:
3370:
3366:
3322:
3321:
3314:
3262:
3261:
3257:
3221:
3220:
3216:
3180:
3179:
3172:
3135:(6632): 520–3.
3125:
3124:
3120:
3080:
3079:
3072:
3049:(21): 2569–82.
3036:
3035:
3031:
3008:(15): 12961–7.
2995:
2994:
2987:
2957:
2956:
2952:
2914:
2913:
2909:
2873:
2872:
2868:
2822:
2821:
2817:
2808:
2807:
2803:
2793:
2791:
2783:
2782:
2778:
2732:
2731:
2727:
2691:
2690:
2686:
2648:
2647:
2643:
2624:Cancer Research
2621:
2620:
2616:
2587:(5019): 562–5.
2577:
2576:
2572:
2559:
2558:
2554:
2541:
2540:
2536:
2524:
2515:
2503:
2494:
2490:
2478:
2466:
2461:
2231:
2203:tyrosine kinase
2137:
2125:phosphorylation
2071:tyrosine kinase
2060:
2013:View/Edit Mouse
2008:View/Edit Human
1971:
1964:
1961:Location (UCSC)
1947:
1943:
1939:
1935:
1931:
1910:
1906:
1880:
1876:
1872:
1868:
1864:
1843:
1839:
1752:ENSG00000097007
1645:
1296:phosphorylation
1089:
988:
904:protein binding
844:kinase activity
794:
763:
754:
749:
745:
741:
737:
733:
729:
725:
721:
717:
703:
692:
687:
683:
679:
675:
671:
667:
663:
659:
655:
641:
585:
572:
564:
554:
553:
552:
545:
525:
502:Gene location (
484:
471:
463:
453:
452:
451:
444:
422:
399:Gene location (
386:
336:
323:
316:
81:
59:
28:
23:
22:
15:
12:
11:
5:
7307:
7305:
7297:
7296:
7291:
7281:
7280:
7276:
7275:
7252:
7251:
7249:
7248:
7235:
7222:
7209:
7196:
7183:
7170:
7156:
7154:
7150:
7149:
7147:
7146:
7141:
7136:
7131:
7126:
7120:
7118:
7114:
7113:
7111:
7110:
7105:
7100:
7095:
7089:
7087:
7086:Classification
7083:
7082:
7080:
7079:
7074:
7069:
7064:
7058:
7056:
7052:
7051:
7049:
7048:
7043:
7038:
7033:
7028:
7023:
7018:
7013:
7007:
7005:
7001:
7000:
6995:
6993:
6992:
6985:
6978:
6970:
6961:
6960:
6957:
6956:
6953:
6952:
6950:
6949:
6944:
6938:
6936:
6929:
6928:
6926:
6925:
6920:
6915:
6910:
6905:
6899:
6897:
6890:
6889:
6887:
6886:
6881:
6876:
6871:
6865:
6863:
6859:
6858:
6856:
6855:
6850:
6845:
6840:
6834:
6832:
6828:
6827:
6825:
6824:
6819:
6814:
6809:
6803:
6801:
6794:
6793:
6791:
6790:
6785:
6780:
6774:
6772:
6765:
6764:
6762:
6761:
6756:
6750:
6748:
6741:
6740:
6738:
6737:
6732:
6726:
6724:
6717:
6716:
6714:
6713:
6708:
6702:
6700:
6693:
6692:
6690:
6689:
6684:
6678:
6676:
6669:
6668:
6666:
6665:
6660:
6654:
6652:
6641:
6640:
6634:
6627:
6626:
6623:
6622:
6619:
6618:
6616:
6615:
6609:
6607:
6603:
6602:
6600:
6599:
6593:
6591:
6584:
6583:
6581:
6580:
6575:
6570:
6564:
6562:
6555:
6554:
6552:
6551:
6546:
6540:
6538:
6535:AATYK receptor
6531:
6530:
6528:
6527:
6521:
6519:
6515:
6514:
6512:
6511:
6505:
6503:
6496:
6495:
6493:
6492:
6486:
6484:
6477:
6476:
6474:
6473:
6467:
6465:
6458:
6457:
6455:
6454:
6449:
6443:
6441:
6434:
6433:
6431:
6430:
6425:
6419:
6417:
6410:
6409:
6407:
6406:
6401:
6395:
6393:
6386:
6385:
6383:
6382:
6377:
6371:
6369:
6362:
6361:
6359:
6358:
6353:
6348:
6343:
6338:
6333:
6328:
6323:
6318:
6313:
6308:
6303:
6298:
6293:
6288:
6282:
6280:
6273:
6272:
6269:
6268:
6266:
6265:
6260:
6255:
6249:
6247:
6240:
6239:
6237:
6236:
6231:
6225:
6223:
6216:
6215:
6213:
6212:
6207:
6202:
6196:
6194:
6191:VEGF receptors
6187:
6186:
6184:
6183:
6178:
6173:
6168:
6162:
6160:
6153:
6152:
6150:
6149:
6143:
6134:
6129:
6124:
6118:
6116:
6110:
6109:
6107:
6106:
6101:
6096:
6090:
6088:
6081:
6080:
6078:
6077:
6072:
6067:
6062:
6056:
6054:
6045:
6035:
6034:
6028:
6021:
6020:
6006:
6004:
6003:
5996:
5989:
5981:
5972:
5971:
5969:
5968:
5962:
5955:
5953:
5947:
5940:
5938:
5932:
5925:
5923:
5917:
5910:
5908:
5902:
5895:
5893:
5887:
5880:
5878:
5872:
5865:
5863:
5857:
5850:
5848:
5842:
5835:
5833:
5827:
5820:
5818:
5812:
5805:
5803:
5797:
5790:
5788:
5782:
5775:
5773:
5767:
5760:
5758:
5752:
5745:
5743:
5737:
5730:
5728:
5722:
5715:
5713:
5707:
5700:
5698:
5692:
5685:
5683:
5677:
5670:
5668:
5662:
5655:
5653:
5647:
5640:
5638:
5632:
5625:
5623:
5617:
5610:
5608:
5602:
5595:
5593:
5587:
5580:
5578:
5572:
5565:
5563:
5557:
5550:
5548:
5542:
5535:
5532:
5529:
5528:
5525:
5523:
5522:
5515:
5508:
5500:
5494:
5493:
5472:
5451:
5432:
5423:
5414:
5403:
5393:
5383:
5371:
5370:External links
5368:
5366:
5365:
5351:
5320:
5285:
5248:
5219:
5205:
5184:
5147:
5112:
5074:
5072:
5069:
5067:
5066:
5018:(6): 496–506.
5001:
4966:
4925:
4881:
4830:
4811:(8): 2707–20.
4794:
4745:
4704:
4663:
4628:
4579:
4558:(6): 1413–23.
4538:
4479:
4430:
4379:
4328:
4285:
4244:
4215:(7): 3327–37.
4195:
4166:(4): 1365–75.
4146:
4097:
4056:
4015:
3994:(5): 2659–67.
3974:
3931:
3890:
3847:
3798:
3749:
3708:
3687:(1): 297–306.
3667:
3621:
3569:
3525:
3484:
3435:
3391:
3380:(2): 298–303.
3364:
3312:
3275:(3): 296–305.
3255:
3214:
3170:
3118:
3085:(April 1999).
3070:
3029:
2985:
2950:
2907:
2866:
2815:
2801:
2776:
2725:
2698:Carcinogenesis
2684:
2651:Genes to Cells
2641:
2630:(8): 2213–22.
2614:
2570:
2552:
2534:
2513:
2491:
2489:
2486:
2485:
2484:
2477:
2474:
2465:
2462:
2460:
2459:
2453:
2447:
2441:
2435:
2429:
2423:
2417:
2411:
2405:
2399:
2393:
2387:
2381:
2375:
2369:
2363:
2357:
2351:
2345:
2339:
2333:
2327:
2321:
2315:
2309:
2303:
2297:
2291:
2285:
2279:
2273:
2267:
2261:
2255:
2249:
2242:
2230:
2227:
2136:
2133:
2067:proto-oncogene
2059:
2056:
2027:also known as
2020:
2019:
2016:
2015:
2010:
2000:
1999:
1993:
1992:
1989:
1988:
1986:
1984:
1977:
1976:
1969:
1962:
1958:
1957:
1954:
1953:
1927:
1926:
1920:
1917:
1916:
1902:
1901:
1895:
1891:
1890:
1887:
1886:
1860:
1859:
1853:
1850:
1849:
1835:
1834:
1828:
1824:
1823:
1820:
1819:
1811:
1810:
1804:
1801:
1800:
1792:
1791:
1785:
1779:
1778:
1775:
1774:
1766:
1765:
1759:
1756:
1755:
1747:
1746:
1740:
1734:
1733:
1730:
1729:
1721:
1720:
1714:
1711:
1710:
1702:
1701:
1695:
1689:
1688:
1683:
1678:
1674:
1673:
1663:
1662:
1659:
1658:
1647:
1646:
1644:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1097:
1095:
1091:
1090:
1088:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
996:
994:
990:
989:
987:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
825:
823:
819:
818:
808:
807:
804:
803:
800:
799:
791:
790:
779:
773:
772:
769:
768:
760:
759:
756:
755:
753:
752:
748:
744:
740:
736:
732:
731:tail of embryo
728:
724:
720:
716:
712:
709:
708:
697:
694:
693:
691:
690:
686:
685:body of uterus
682:
678:
674:
670:
669:gastric mucosa
666:
662:
658:
654:
650:
647:
646:
634:
633:
625:
614:
608:
607:
604:RNA expression
596:
595:
592:
591:
583:
579:
578:
570:
567:
562:
556:
555:
546:
539:
533:
529:
528:
523:
517:
516:
508:
507:
495:
494:
491:
490:
482:
478:
477:
469:
466:
461:
455:
454:
445:
438:
432:
428:
427:
420:
414:
413:
405:
404:
392:
391:
384:
378:
377:
334:
330:
329:
321:
313:
312:
308:
307:
304:
303:
300:
299:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7306:
7295:
7292:
7290:
7287:
7286:
7284:
7274:
7269:
7264:
7260:
7246:
7242:
7241:
7236:
7233:
7229:
7228:
7223:
7220:
7216:
7215:
7210:
7207:
7203:
7202:
7197:
7194:
7190:
7189:
7184:
7181:
7177:
7176:
7171:
7168:
7164:
7163:
7158:
7157:
7155:
7151:
7145:
7142:
7140:
7137:
7135:
7132:
7130:
7127:
7125:
7122:
7121:
7119:
7115:
7109:
7106:
7104:
7103:Enzyme family
7101:
7099:
7096:
7094:
7091:
7090:
7088:
7084:
7078:
7075:
7073:
7070:
7068:
7067:Cooperativity
7065:
7063:
7060:
7059:
7057:
7053:
7047:
7044:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7026:Oxyanion hole
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7008:
7006:
7002:
6998:
6991:
6986:
6984:
6979:
6977:
6972:
6971:
6968:
6948:
6945:
6943:
6940:
6939:
6937:
6934:
6930:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6900:
6898:
6895:
6891:
6885:
6882:
6880:
6877:
6875:
6872:
6870:
6867:
6866:
6864:
6860:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6836:
6835:
6833:
6829:
6823:
6820:
6818:
6815:
6813:
6810:
6808:
6805:
6804:
6802:
6799:
6795:
6789:
6786:
6784:
6781:
6779:
6776:
6775:
6773:
6770:
6766:
6760:
6757:
6755:
6752:
6751:
6749:
6746:
6742:
6736:
6733:
6731:
6728:
6727:
6725:
6722:
6718:
6712:
6709:
6707:
6704:
6703:
6701:
6698:
6694:
6688:
6685:
6683:
6680:
6679:
6677:
6674:
6670:
6664:
6661:
6659:
6656:
6655:
6653:
6650:
6646:
6642:
6638:(EC 2.7.10.2)
6637:
6632:
6628:
6614:
6611:
6610:
6608:
6606:uncategorised
6604:
6598:
6595:
6594:
6592:
6589:
6585:
6579:
6576:
6574:
6571:
6569:
6566:
6565:
6563:
6560:
6556:
6550:
6547:
6545:
6542:
6541:
6539:
6536:
6532:
6526:
6523:
6522:
6520:
6516:
6510:
6507:
6506:
6504:
6501:
6500:MuSK receptor
6497:
6491:
6488:
6487:
6485:
6482:
6478:
6472:
6469:
6468:
6466:
6463:
6462:PTK7 receptor
6459:
6453:
6450:
6448:
6445:
6444:
6442:
6439:
6435:
6429:
6426:
6424:
6421:
6420:
6418:
6415:
6411:
6405:
6402:
6400:
6397:
6396:
6394:
6391:
6387:
6381:
6378:
6376:
6373:
6372:
6370:
6367:
6363:
6357:
6354:
6352:
6349:
6347:
6344:
6342:
6339:
6337:
6334:
6332:
6329:
6327:
6324:
6322:
6319:
6317:
6314:
6312:
6309:
6307:
6304:
6302:
6299:
6297:
6294:
6292:
6289:
6287:
6284:
6283:
6281:
6278:
6274:
6264:
6261:
6259:
6256:
6254:
6251:
6250:
6248:
6245:
6241:
6235:
6232:
6230:
6227:
6226:
6224:
6221:
6217:
6211:
6208:
6206:
6203:
6201:
6198:
6197:
6195:
6192:
6188:
6182:
6179:
6177:
6174:
6172:
6169:
6167:
6164:
6163:
6161:
6158:
6154:
6147:
6144:
6142:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6119:
6117:
6115:
6111:
6105:
6102:
6100:
6097:
6095:
6092:
6091:
6089:
6086:
6082:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6057:
6055:
6053:
6049:
6046:
6044:
6040:
6036:
6032:(EC 2.7.10.1)
6031:
6026:
6022:
6017:
6013:
6009:
6002:
5997:
5995:
5990:
5988:
5983:
5982:
5979:
5965:
5959:
5954:
5950:
5944:
5939:
5935:
5929:
5924:
5920:
5914:
5909:
5905:
5899:
5894:
5890:
5884:
5879:
5875:
5869:
5864:
5860:
5854:
5849:
5845:
5839:
5834:
5830:
5824:
5819:
5815:
5809:
5804:
5800:
5794:
5789:
5785:
5779:
5774:
5770:
5764:
5759:
5755:
5749:
5744:
5740:
5734:
5729:
5725:
5719:
5714:
5710:
5704:
5699:
5695:
5689:
5684:
5680:
5674:
5669:
5665:
5659:
5654:
5650:
5644:
5639:
5635:
5629:
5624:
5620:
5614:
5609:
5605:
5599:
5594:
5590:
5584:
5579:
5575:
5569:
5564:
5560:
5554:
5549:
5545:
5539:
5534:
5530:
5521:
5516:
5514:
5509:
5507:
5502:
5501:
5498:
5491:
5487:
5486:
5481:
5477:
5473:
5470:
5466:
5465:
5460:
5456:
5452:
5449:
5445:
5444:
5439:
5438:
5433:
5431:
5427:
5424:
5422:
5418:
5415:
5413:
5411:
5408:
5404:
5401:
5397:
5394:
5391:
5387:
5384:
5381:
5377:
5374:
5373:
5369:
5362:
5358:
5354:
5348:
5344:
5340:
5336:
5332:
5327:
5321:
5317:
5313:
5308:
5303:
5299:
5295:
5291:
5286:
5282:
5278:
5274:
5270:
5266:
5262:
5258:
5254:
5249:
5245:
5241:
5237:
5233:
5230:(2): 139–42.
5229:
5225:
5220:
5216:
5212:
5208:
5202:
5198:
5194:
5190:
5185:
5181:
5177:
5173:
5169:
5165:
5161:
5157:
5153:
5148:
5144:
5140:
5135:
5130:
5126:
5122:
5118:
5113:
5109:
5105:
5101:
5097:
5093:
5089:
5085:
5081:
5076:
5075:
5070:
5062:
5058:
5054:
5050:
5043:
5039:
5034:
5029:
5025:
5021:
5017:
5013:
5005:
5002:
4997:
4993:
4989:
4985:
4981:
4977:
4970:
4967:
4962:
4958:
4953:
4948:
4944:
4940:
4939:J. Biol. Chem
4936:
4929:
4926:
4921:
4917:
4912:
4907:
4903:
4899:
4898:J. Biol. Chem
4895:
4888:
4886:
4882:
4877:
4873:
4868:
4863:
4858:
4853:
4849:
4845:
4844:J. Biol. Chem
4841:
4834:
4831:
4826:
4822:
4818:
4814:
4810:
4806:
4798:
4795:
4790:
4786:
4781:
4776:
4772:
4768:
4764:
4760:
4756:
4749:
4746:
4741:
4737:
4732:
4727:
4723:
4719:
4715:
4708:
4705:
4700:
4696:
4691:
4686:
4683:(4): 779–90.
4682:
4678:
4674:
4667:
4664:
4659:
4655:
4651:
4647:
4644:(2): 115–21.
4643:
4639:
4632:
4629:
4624:
4620:
4615:
4610:
4606:
4602:
4598:
4594:
4590:
4583:
4580:
4575:
4571:
4566:
4561:
4557:
4553:
4549:
4542:
4539:
4534:
4530:
4525:
4520:
4515:
4510:
4506:
4502:
4498:
4494:
4490:
4483:
4480:
4475:
4471:
4466:
4461:
4457:
4453:
4449:
4445:
4441:
4434:
4431:
4426:
4422:
4418:
4414:
4410:
4409:10.1038/21697
4406:
4402:
4398:
4394:
4390:
4383:
4380:
4375:
4371:
4367:
4363:
4359:
4358:10.1038/21704
4355:
4351:
4347:
4343:
4339:
4332:
4329:
4324:
4320:
4316:
4312:
4308:
4304:
4301:(3): 356–64.
4300:
4296:
4289:
4286:
4281:
4277:
4272:
4267:
4263:
4259:
4255:
4248:
4245:
4240:
4236:
4231:
4226:
4222:
4218:
4214:
4210:
4206:
4199:
4196:
4191:
4187:
4182:
4177:
4173:
4169:
4165:
4161:
4157:
4150:
4147:
4142:
4138:
4133:
4128:
4124:
4120:
4116:
4112:
4108:
4101:
4098:
4093:
4089:
4084:
4079:
4075:
4071:
4070:J. Biol. Chem
4067:
4060:
4057:
4052:
4048:
4043:
4038:
4034:
4030:
4029:J. Biol. Chem
4026:
4019:
4016:
4011:
4007:
4002:
3997:
3993:
3989:
3988:J. Biol. Chem
3985:
3978:
3975:
3970:
3966:
3962:
3958:
3954:
3950:
3946:
3942:
3935:
3932:
3927:
3923:
3918:
3913:
3909:
3905:
3904:J. Biol. Chem
3901:
3894:
3891:
3886:
3882:
3878:
3874:
3870:
3866:
3862:
3858:
3851:
3848:
3843:
3839:
3835:
3831:
3826:
3821:
3818:(2): 205–11.
3817:
3813:
3809:
3802:
3799:
3794:
3790:
3785:
3780:
3776:
3772:
3768:
3764:
3760:
3753:
3750:
3745:
3741:
3736:
3731:
3727:
3723:
3719:
3712:
3709:
3704:
3700:
3695:
3690:
3686:
3682:
3678:
3671:
3668:
3663:
3659:
3654:
3649:
3646:(7): 783–95.
3645:
3641:
3637:
3630:
3628:
3626:
3622:
3617:
3613:
3608:
3603:
3599:
3595:
3591:
3587:
3583:
3576:
3574:
3570:
3565:
3561:
3556:
3551:
3547:
3543:
3539:
3532:
3530:
3526:
3521:
3517:
3512:
3507:
3503:
3499:
3498:J. Biol. Chem
3495:
3488:
3485:
3480:
3476:
3471:
3466:
3462:
3458:
3454:
3450:
3446:
3439:
3436:
3431:
3427:
3423:
3419:
3415:
3411:
3408:(1): 161–71.
3407:
3403:
3395:
3392:
3387:
3383:
3379:
3375:
3368:
3365:
3360:
3356:
3351:
3346:
3342:
3338:
3335:(4): 764–73.
3334:
3330:
3326:
3319:
3317:
3313:
3308:
3304:
3300:
3296:
3291:
3286:
3282:
3278:
3274:
3270:
3266:
3259:
3256:
3251:
3247:
3242:
3237:
3233:
3229:
3228:J. Biol. Chem
3225:
3218:
3215:
3210:
3206:
3201:
3196:
3192:
3188:
3187:J. Biol. Chem
3184:
3177:
3175:
3171:
3166:
3162:
3158:
3154:
3150:
3146:
3142:
3138:
3134:
3130:
3122:
3119:
3114:
3110:
3105:
3100:
3096:
3092:
3091:J. Biol. Chem
3088:
3084:
3077:
3075:
3071:
3066:
3062:
3057:
3052:
3048:
3044:
3040:
3033:
3030:
3025:
3021:
3016:
3011:
3007:
3003:
3002:J. Biol. Chem
2999:
2992:
2990:
2986:
2981:
2977:
2973:
2969:
2966:(2): 159–69.
2965:
2961:
2954:
2951:
2946:
2942:
2938:
2934:
2930:
2926:
2923:(2): 233–41.
2922:
2918:
2911:
2908:
2903:
2899:
2894:
2889:
2885:
2881:
2880:J. Biol. Chem
2877:
2870:
2867:
2862:
2858:
2854:
2850:
2846:
2842:
2838:
2834:
2830:
2826:
2819:
2816:
2811:
2805:
2802:
2790:
2786:
2780:
2777:
2772:
2768:
2763:
2758:
2753:
2748:
2744:
2740:
2736:
2729:
2726:
2721:
2717:
2712:
2707:
2703:
2699:
2695:
2688:
2685:
2680:
2676:
2672:
2668:
2664:
2660:
2657:(9): 781–90.
2656:
2652:
2645:
2642:
2637:
2633:
2629:
2625:
2618:
2615:
2610:
2606:
2602:
2598:
2594:
2590:
2586:
2582:
2574:
2571:
2566:
2562:
2556:
2553:
2548:
2544:
2538:
2535:
2531:
2527:
2522:
2520:
2518:
2514:
2510:
2506:
2501:
2499:
2497:
2493:
2487:
2483:
2480:
2479:
2475:
2473:
2471:
2463:
2457:
2454:
2451:
2448:
2445:
2442:
2439:
2436:
2433:
2430:
2427:
2424:
2421:
2418:
2415:
2412:
2409:
2406:
2403:
2400:
2397:
2394:
2391:
2388:
2385:
2382:
2379:
2376:
2373:
2370:
2367:
2364:
2361:
2358:
2355:
2352:
2349:
2346:
2343:
2340:
2337:
2334:
2331:
2328:
2325:
2322:
2319:
2316:
2313:
2310:
2307:
2304:
2301:
2298:
2295:
2292:
2289:
2286:
2283:
2280:
2277:
2274:
2271:
2268:
2265:
2262:
2259:
2256:
2253:
2250:
2247:
2244:
2243:
2241:
2239:
2235:
2228:
2226:
2224:
2220:
2216:
2212:
2208:
2204:
2200:
2196:
2192:
2188:
2183:
2181:
2177:
2173:
2169:
2165:
2161:
2157:
2149:
2146:
2141:
2134:
2132:
2130:
2126:
2122:
2118:
2114:
2110:
2106:
2105:
2100:
2096:
2092:
2088:
2084:
2080:
2079:cell adhesion
2076:
2075:cell division
2072:
2068:
2065:
2057:
2055:
2053:
2049:
2046:) located on
2045:
2041:
2038:
2034:
2030:
2026:
2014:
2009:
2005:
2001:
1998:
1994:
1987:
1985:
1982:
1978:
1974:
1970:
1967:
1963:
1959:
1952:
1950:
1946:
1942:
1938:
1934:
1928:
1924:
1921:
1915:
1913:
1909:
1903:
1899:
1896:
1892:
1885:
1883:
1879:
1875:
1871:
1867:
1861:
1857:
1854:
1848:
1846:
1842:
1836:
1832:
1829:
1827:RefSeq (mRNA)
1825:
1818:
1817:
1812:
1808:
1805:
1799:
1798:
1793:
1789:
1786:
1784:
1780:
1773:
1772:
1767:
1763:
1760:
1754:
1753:
1748:
1744:
1741:
1739:
1735:
1728:
1727:
1722:
1718:
1715:
1709:
1708:
1703:
1699:
1696:
1694:
1690:
1687:
1684:
1682:
1679:
1675:
1672:
1668:
1664:
1657:
1653:
1648:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1331:cell adhesion
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1098:
1096:
1093:
1092:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1025:mitochondrion
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
997:
995:
992:
991:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
826:
824:
821:
820:
817:
816:Gene ontology
813:
809:
797:
792:
788:
783:
780:
778:
774:
766:
761:
750:
746:
742:
738:
734:
730:
726:
723:Gonadal ridge
722:
718:
714:
713:
710:
706:
701:
698:
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
651:
648:
644:
639:
636:
635:
632:
630:
626:
624:
623:
619:
618:
615:
613:
609:
605:
601:
597:
589:
584:
580:
576:
571:
561:
557:
550:
543:
537:
530:
522:
518:
514:
509:
505:
500:
496:
488:
483:
479:
475:
470:
460:
456:
449:
442:
436:
429:
425:
419:
415:
411:
406:
402:
397:
393:
389:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
331:
326:
319:
314:
309:
298:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
30:
19:
7240:Translocases
7237:
7224:
7211:
7198:
7185:
7175:Transferases
7172:
7159:
7016:Binding site
6862:SRC-B family
6831:SRC-A family
6648:
6588:RET receptor
6559:AXL receptor
6481:RYK receptor
6438:DDR receptor
6414:ROR receptor
6390:TIE receptor
6366:LTK receptor
6277:EPH receptor
6244:Trk receptor
6220:HGF receptor
6157:FGF receptor
5963:
5948:
5933:
5918:
5903:
5888:
5873:
5858:
5843:
5828:
5813:
5798:
5783:
5768:
5753:
5738:
5723:
5708:
5693:
5678:
5663:
5648:
5633:
5618:
5603:
5588:
5573:
5558:
5543:
5483:
5462:
5442:
5436:
5409:
5406:
5330:
5297:
5293:
5256:
5252:
5227:
5223:
5188:
5158:(1): 35–43.
5155:
5151:
5124:
5120:
5083:
5079:
5015:
5011:
5004:
4979:
4975:
4969:
4942:
4938:
4928:
4901:
4897:
4847:
4843:
4833:
4808:
4804:
4797:
4762:
4758:
4748:
4721:
4717:
4707:
4680:
4676:
4666:
4641:
4637:
4631:
4596:
4592:
4582:
4555:
4551:
4541:
4496:
4492:
4482:
4447:
4443:
4433:
4392:
4388:
4382:
4341:
4337:
4331:
4298:
4294:
4288:
4261:
4257:
4247:
4212:
4208:
4198:
4163:
4159:
4149:
4114:
4110:
4100:
4073:
4069:
4059:
4032:
4028:
4018:
3991:
3987:
3977:
3947:(8): 941–8.
3944:
3940:
3934:
3907:
3903:
3893:
3860:
3856:
3850:
3815:
3811:
3801:
3766:
3762:
3752:
3725:
3721:
3711:
3684:
3680:
3670:
3643:
3639:
3589:
3585:
3545:
3541:
3501:
3497:
3487:
3452:
3448:
3438:
3405:
3401:
3394:
3377:
3373:
3367:
3332:
3328:
3272:
3268:
3258:
3231:
3227:
3217:
3190:
3186:
3132:
3128:
3121:
3094:
3090:
3046:
3042:
3032:
3005:
3001:
2963:
2959:
2953:
2920:
2916:
2910:
2883:
2879:
2869:
2828:
2824:
2818:
2804:
2792:. Retrieved
2788:
2779:
2742:
2738:
2728:
2704:(1): 27–34.
2701:
2697:
2687:
2654:
2650:
2644:
2627:
2623:
2617:
2584:
2580:
2573:
2564:
2555:
2546:
2537:
2467:
2233:
2232:
2229:Interactions
2189:gene in the
2186:
2184:
2171:
2164:translocated
2155:
2153:
2128:
2108:
2102:
2063:
2061:
2048:chromosome 9
2043:
2036:
2028:
2024:
2023:
1945:NP_001269976
1941:NP_001269975
1937:NP_001269974
1933:NP_001106174
1930:
1905:
1882:NM_001283047
1878:NM_001283046
1874:NM_001283045
1866:NM_001112703
1863:
1838:
1814:
1795:
1769:
1750:
1724:
1705:
1685:
1680:
1251:phagocytosis
1065:nuclear body
1040:cytoskeleton
735:vas deferens
653:frontal pole
627:
620:
485:130,887,675
472:130,713,016
333:External IDs
80:
29:
7011:Active site
5526:PDB gallery
5300:(1): 33–5.
5127:(1): 10–6.
5012:Cancer Cell
4264:(1): 72–6.
4160:J. Exp. Med
2113:fusion gene
1386:endocytosis
1085:postsynapse
1055:nucleoplasm
919:DNA binding
859:ATP binding
586:31,694,239
573:31,578,388
311:Identifiers
7283:Categories
7214:Isomerases
7188:Hydrolases
7055:Regulation
5407:Drosophila
5376:Genes,+abl
5033:10261/7369
3722:J. Immunol
3586:Biochem. J
3374:Cancer Res
3269:Curr. Biol
2532:, May 2017
2511:, May 2017
2488:References
2464:Regulation
2219:cell cycle
2207:cell cycle
2123:-mediated
2087:SH3 domain
2083:DNA repair
1506:DNA repair
631:(ortholog)
354:HomoloGene
7093:EC number
4552:Mol. Cell
4444:Genes Dev
4258:FEBS Lett
3784:1765/9530
3640:Genes Dev
3043:Genes Dev
2180:cancerous
2176:cytokines
2148:nilotinib
1949:NP_033724
1912:NP_009297
1908:NP_005148
1870:NM_009594
1845:NM_005157
1841:NM_007313
1671:Orthologs
1426:autophagy
1050:nucleolus
1000:cytoplasm
382:EC number
362:GeneCards
7117:Kinetics
7041:Cofactor
7004:Activity
5388:(OMIM):
5361:17695727
5316:15686624
5294:Cell Res
5281:35998018
5273:15583852
5244:12505259
5215:12374288
5180:10269867
5172:12138893
5143:10713716
5108:42502628
5100:12476303
5080:Oncogene
5061:27070707
5042:18538733
4996:15175272
4961:11790798
4825:10194451
4718:Oncogene
4623:11971963
4574:11163214
4533:11121037
4417:10391250
4366:10391251
4323:10977765
4315:10679771
4280:10708759
4141:12110584
4051:10753870
3969:20866214
3941:Oncogene
3926:12893824
3885:25752193
3877:11494128
3857:Oncogene
3842:14205526
3793:11071635
3616:12475393
3564:11494134
3542:Oncogene
3520:12777400
3479:12024016
3386:12543778
3307:16957239
3209:11375976
3113:10212258
3024:12569093
2980:11418237
2945:22964580
2917:Oncogene
2902:12672821
2861:34972913
2853:15256671
2771:34616682
2745:: 3666.
2720:20974687
2679:22916981
2671:15330855
2528:–
2507:–
2482:BCR gene
2476:See also
2238:interact
2199:leukemia
2091:oncogene
2058:Function
1997:Wikidata
1650:Sources:
1070:dendrite
1015:membrane
388:2.7.10.2
7273:Biology
7227:Ligases
6997:Enzymes
6018:2.7.10)
5490:PDBe-KB
5480:UniProt
5469:PDBe-KB
5459:UniProt
5428:on the
4920:9593709
4876:9211900
4789:8943360
4740:9583676
4699:8242749
4658:9071815
4501:Bibcode
4474:9334312
4425:4394015
4397:Bibcode
4374:4421613
4346:Bibcode
4239:8668148
4190:8879209
4181:2192828
4092:9407116
4010:9006901
3961:9747873
3834:9008161
3744:9820532
3703:8978305
3662:7926767
3607:1223168
3430:9933891
3422:1712671
3359:8112292
3299:7780740
3277:Bibcode
3250:8810278
3165:4334242
3157:9168117
3137:Bibcode
3065:7590236
2937:9010225
2833:Bibcode
2825:Science
2789:Uniprot
2762:8488401
2636:4318922
2609:1857987
2589:Bibcode
2581:Science
2530:Ensembl
2509:Ensembl
2470:miR-203
2384:PSTPIP1
2172:BCR-ABL
2101:of the
2033:protein
1783:UniProt
1738:Ensembl
1677:Species
1656:QuickGO
1045:nucleus
1005:cytosol
739:condyle
606:pattern
464:9q34.12
318:Aliases
7259:Portal
7201:Lyases
6935:family
6896:family
6800:family
6771:family
6747:family
6723:family
6699:family
6675:family
6651:family
6590:family
6561:family
6549:AATYK2
6537:family
6502:family
6483:family
6464:family
6440:family
6416:family
6392:family
6368:family
6279:family
6246:family
6222:family
6210:VEGFR3
6205:VEGFR2
6200:VEGFR1
6193:family
6159:family
6146:PDGFRB
6141:PDGFRA
6087:family
5485:P00520
5464:P00519
5434:Human
5402:(MeSH)
5390:189980
5382:(MeSH)
5359:
5349:
5335:155–65
5314:
5279:
5271:
5242:
5213:
5203:
5178:
5170:
5141:
5106:
5098:
5059:
5055:,
5040:
4994:
4959:
4918:
4874:
4823:
4787:
4780:231708
4777:
4738:
4697:
4656:
4621:
4614:133797
4611:
4572:
4531:
4521:
4472:
4465:316562
4462:
4423:
4415:
4389:Nature
4372:
4364:
4338:Nature
4321:
4313:
4278:
4237:
4230:231327
4227:
4188:
4178:
4139:
4132:125401
4129:
4111:EMBO J
4090:
4049:
4008:
3967:
3959:
3924:
3883:
3875:
3840:
3832:
3791:
3742:
3701:
3660:
3614:
3604:
3562:
3518:
3477:
3470:133860
3467:
3428:
3420:
3384:
3357:
3350:394874
3347:
3329:EMBO J
3305:
3297:
3248:
3207:
3163:
3155:
3129:Nature
3111:
3083:Lee EY
3063:
3022:
2978:
2943:
2935:
2900:
2859:
2851:
2794:18 May
2769:
2759:
2718:
2677:
2669:
2634:
2607:
2456:YTHDC1
2438:SPTAN1
2426:SORBS2
2240:with:
2099:fusion
2093:. The
1983:search
1981:PubMed
1816:P00520
1797:P00519
1693:Entrez
777:BioGPS
342:189980
7153:Types
6947:ZAP70
6613:STYK1
6578:TYRO3
6544:AATYK
6351:EPHB6
6346:EPHB5
6341:EPHB4
6336:EPHB3
6331:EPHB2
6326:EPHB1
6321:EPHA8
6316:EPHA7
6311:EPHA6
6306:EPHA5
6301:EPHA4
6296:EPHA3
6291:EPHA2
6286:EPHA1
6263:NTRK3
6258:NTRK2
6253:NTRK1
6181:FGFR4
6176:FGFR3
6171:FGFR2
6166:FGFR1
6137:PDGFR
6122:CSF1R
6104:INSRR
6094:IGF1R
6075:ERBB4
6070:ERBB3
6065:ERBB2
5392:(ABL)
5277:S2CID
5176:S2CID
5104:S2CID
4805:Blood
4524:18921
4421:S2CID
4370:S2CID
4319:S2CID
3965:S2CID
3881:S2CID
3838:S2CID
3763:Blood
3681:Blood
3426:S2CID
3303:S2CID
3161:S2CID
2941:S2CID
2857:S2CID
2675:S2CID
2452:, and
2444:TERF1
2432:SPTA1
2396:RAD51
2390:RAD9A
2360:NTRK1
2354:NEDD9
2324:GRB10
2312:EPHB2
2282:BRCA1
2270:BCAR1
2150:(red)
2031:is a
1726:11350
1686:Mouse
1681:Human
1652:Amigo
629:Mouse
622:Human
569:Start
504:Mouse
468:Start
401:Human
350:87859
7245:list
7238:EC7
7232:list
7225:EC6
7219:list
7212:EC5
7206:list
7199:EC4
7193:list
7186:EC3
7180:list
7173:EC2
7167:list
7160:EC1
6853:YES1
6822:TYK2
6817:JAK3
6812:JAK2
6807:JAK1
6788:SRMS
6735:PYK2
6711:MATK
6687:TNK1
6682:ACK1
6658:ABL1
6525:ROS1
6509:MUSK
6471:PTK7
6452:DDR2
6447:DDR1
6428:ROR2
6423:ROR1
6356:EPHX
6127:FLT3
6099:INSR
6060:EGFR
5964:2o88
5949:2hzn
5934:2hzi
5919:2hz4
5904:2hz0
5889:2hyy
5874:2hiw
5859:2gqg
5844:2g2i
5829:2g2h
5814:2g2f
5799:2g1t
5784:2fo0
5769:2f4j
5754:2e2b
5739:2abl
5724:1zzp
5709:1opl
5694:1opk
5679:1opj
5664:1m52
5649:1ju5
5634:1iep
5619:1fpu
5604:1bbz
5589:1awo
5574:1abq
5559:1abo
5544:1ab2
5478:for
5457:for
5443:ABL1
5437:ABL1
5426:ABL1
5417:ABL1
5357:PMID
5347:ISBN
5312:PMID
5269:PMID
5240:PMID
5211:PMID
5201:ISBN
5168:PMID
5139:PMID
5096:PMID
5057:PMID
5038:PMID
4992:PMID
4957:PMID
4916:PMID
4872:PMID
4821:PMID
4785:PMID
4736:PMID
4695:PMID
4677:Cell
4654:PMID
4619:PMID
4570:PMID
4529:PMID
4470:PMID
4413:PMID
4362:PMID
4311:PMID
4276:PMID
4235:PMID
4186:PMID
4137:PMID
4088:PMID
4047:PMID
4006:PMID
3957:PMID
3922:PMID
3873:PMID
3830:PMID
3812:Cell
3789:PMID
3740:PMID
3699:PMID
3658:PMID
3612:PMID
3560:PMID
3516:PMID
3475:PMID
3418:PMID
3402:Cell
3382:PMID
3355:PMID
3295:PMID
3246:PMID
3205:PMID
3153:PMID
3109:PMID
3061:PMID
3020:PMID
2976:PMID
2960:Gene
2933:PMID
2898:PMID
2849:PMID
2796:2020
2767:PMID
2716:PMID
2667:PMID
2632:PMID
2605:PMID
2450:VAV1
2420:SHC1
2414:RYBP
2408:RFX1
2378:PAK2
2372:PAG1
2348:NCK1
2342:MDM2
2336:GRB2
2330:MTOR
2318:GPX1
2306:DOK1
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