306:
283:
180:
205:
557:
29:
312:
211:
3183:
2380:
Matsukawa M, Kaikita K, Soejima K, Fuchigami S, Nakamura Y, Honda T, Tsujita K, Nagayoshi Y, Kojima S, Shimomura H, Sugiyama S, Fujimoto K, Yoshimura M, Nakagaki T, Ogawa H (September 2007). "Serial changes in von
Willebrand factor-cleaving protease (ADAMTS13) and prognosis after acute myocardial
55:
1286:
at 1606 by a plasma metalloprotease enzyme when it was exposed to high levels of shear stress. In 1996, two research groups independently further characterized this enzyme. In the next two years, the same two groups showed that the congenital deficiency of a vWF-cleaving
1593:
Furlan M, Lämmle B (June 2001). "Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von
Willebrand factor-cleaving protease".
319:
218:
2507:
1723:
Sonneveld MA, de Maat MP, Portegies ML, Kavousi M, Hofman A, Turecek PL, Rottensteiner H, Scheiflinger F, Koudstaal PJ, Ikram MA, Leebeek FW (December 2015).
1325:
domains. ADAMTS13 in fact has eight thrombospondin domains. It has no hydrophobic transmembrane domain, and hence it is not anchored in the cell membrane.
870:
1857:
Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K (January 2002). "Von
Willebrand factor-cleaving protease and Upshaw-Schulman syndrome".
851:
141:
1356:
Low levels of ADAMTS13 are also associated with an increased risk of arterial thrombosis, including myocardial infarction and cerebrovascular disease.
1628:
Sonneveld MA, de Maat MP, Leebeek FW (July 2014). "Von
Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis".
1472:
2849:
1454:
3203:
1275:(see below), was characterized in its familial form by the presence in plasma of unusually large von Willebrand factor multimers (ULVWF).
2443:
2536:
2500:
2427:
1338:
1268:
1118:
305:
2902:
1272:
1125:
282:
2436:
1974:"Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura"
1663:
Maino A, Siegerink B, Lotta LA, Crawley JT, le Cessie S, Leebeek FW, Lane DA, Lowe GD, Peyvandi F, Rosendaal FR (August 2015).
1441:
1420:
2449:
2493:
3058:
1437:
204:
179:
52:
1416:
3173:
2854:
2240:"The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of thrombotic thrombocytopenic purpura (TTP)"
318:
217:
121:
311:
210:
1664:
2748:
2743:
1317:, all of which are characterised by a protease domain (the part that performs the protein hydrolysis), an adjacent
3043:
3159:
3146:
3133:
3120:
3107:
3094:
3081:
2527:
3053:
2180:
Kokame K, Miyata T (January 2004). "Genetic defects leading to hereditary thrombotic thrombocytopenic purpura".
3007:
2950:
2864:
2681:
2524:
1334:
919:
129:
2151:
Plaimauer B, Scheiflinger F (January 2004). "Expression and characterization of recombinant human ADAMTS-13".
1375:), it has been accepted that increased exposure of vWf to ADAMTS13 due to various reasons would predispose to
2209:
Schneppenheim R, Budde U, Hassenpflug W, Obser T (January 2004). "Severe ADAMTS-13 deficiency in childhood".
2955:
900:
896:
1764:
Denorme F, Kraft P, Pareyn I, Drechsler C, Deckmyn H, Vanhoorelbeke K, Kleinschnitz C, De Meyer SF (2017).
1380:
2122:
LĂłpez JA, Dong JF (January 2004). "Cleavage of von
Willebrand factor by ADAMTS-13 on endothelial cells".
1665:"Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis"
2976:
2895:
2839:
1360:
1225:
112:, ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP, ADAM metallopeptidase with thrombospondin type 1 motif 13
3048:
2316:
George JN (May 2005). "ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome".
2093:
Moake JL (January 2004). "von
Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura".
2520:
1777:
193:
1935:
Tsai HM (October 2002). "Von
Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura".
108:
3012:
2455:
1372:
1101:
1097:
1093:
1089:
1034:
1030:
1026:
1022:
3208:
2945:
2368:
2304:
2081:
2038:
1960:
1923:
1882:
1705:
1534:
153:
1068:
1064:
1060:
1001:
997:
993:
989:
2485:
1554:"Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura"
556:
2462:
2398:
2360:
2325:
2296:
2261:
2226:
2197:
2168:
2139:
2110:
2073:
2030:
1995:
1952:
1915:
1874:
1845:
1805:
1746:
1697:
1645:
1610:
1575:
1526:
149:
101:
45:
2991:
2986:
2960:
2888:
2788:
2390:
2350:
2286:
2251:
2218:
2189:
2160:
2131:
2102:
2063:
2020:
1985:
1944:
1907:
1866:
1837:
1795:
1785:
1736:
1689:
1679:
1637:
1602:
1565:
1516:
1299:
398:
329:
273:
228:
2422:
28:
3213:
3038:
3022:
2935:
2544:
1218:
373:
2009:"Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes"
1553:
1781:
3187:
3076:
3017:
2222:
2193:
2164:
2135:
2106:
1990:
1973:
1895:
1800:
1765:
1570:
1379:
by causing increased degradation of vWf. This phenomenon is characterised by a form of
1364:
1346:
1322:
1841:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
679:
674:
669:
664:
659:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
3197:
2981:
2940:
2471:
2355:
2338:
2068:
2051:
2025:
2008:
1911:
585:
2372:
2308:
2085:
2042:
1964:
1927:
1886:
1828:
Tang BL (January 2001). "ADAMTS: a novel family of extracellular matrix proteases".
1766:"Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease"
1538:
133:
2930:
1368:
391:
170:
2394:
2339:"Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions"
1709:
1349:
and characterisation of IgG inhibitors. Since the discovery of ADAMTS13, specific
1305:
directed against this same enzyme caused TTP in a majority of non-familial cases.
1790:
1741:
1724:
157:
3154:
3089:
2925:
2859:
2844:
2689:
1477:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1459:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1318:
1229:
3182:
2291:
2274:
1725:"Low ADAMTS13 activity is associated with an increased risk of ischemic stroke"
1641:
1521:
1504:
474:
2834:
2706:
2052:"Is ADAMTS-13 deficiency specific for thrombotic thrombocytopenic purpura? No"
1948:
1376:
1342:
1283:
1256:
290:
187:
137:
3128:
3102:
1417:
ENSG00000281244 GRCh38: Ensembl release 89: ENSG00000160323, ENSG00000281244
815:
534:
412:
357:
344:
256:
243:
145:
2475:(A disintegrin and metalloproteinase with thrombospondin motifs 13) at the
2402:
2364:
2329:
2300:
2265:
2230:
2201:
2172:
2143:
2114:
2077:
2034:
1999:
1956:
1919:
1878:
1849:
1809:
1750:
1701:
1693:
1649:
1614:
1606:
1579:
1530:
1353:
on its surface have been shown to be the target of inhibitory antibodies.
1165:
1160:
2869:
2666:
2661:
2516:
1302:
1295:
1292:
1288:
1279:
1149:
964:
945:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2476:
2466:
1870:
1392:
1350:
931:
882:
2256:
2239:
1684:
78:
74:
3141:
2911:
2793:
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2564:
2559:
2554:
2418:
1314:
1221:
1133:
837:
1236:
and degrades large vWf multimers, decreasing their activity, hence
3115:
2818:
2813:
2808:
2803:
2798:
2783:
2778:
2773:
2768:
2763:
2758:
2753:
2738:
2733:
2581:
2576:
2571:
2549:
1233:
1341:. By that time it was already suspected that TTP occurred in the
800:
796:
2728:
2723:
2716:
2711:
2699:
2694:
2431:
1313:
Genomically, ADAMTS13 shares many properties with the 19 member
1252:
1214:
565:
125:
2884:
2489:
2461:
Overview of all the structural information available in the
1830:
1298:
in the small blood vessels. In addition, they reported that
2880:
381:
3171:
2421:
online database for peptidases and their inhibitors:
546:
1333:
Deficiency of ADAMTS13 was originally discovered in
3067:
3031:
3000:
2969:
2918:
2827:
2680:
2535:
1082:
1053:
1015:
982:
489:
dentate gyrus of hippocampal formation granule cell
1978:Arteriosclerosis, Thrombosis, and Vascular Biology
1595:Best Practice & Research. Clinical Haematology
1433:
1431:
1429:
1412:
1410:
1408:
328:
227:
1278:In 1994, vWF was shown to be cleaved between a
2238:Kremer Hovinga JA, Studt JD, Lämmle B (2005).
1438:GRCm38: Ensembl release 89: ENSMUSG00000014852
2896:
2501:
2244:Pathophysiology of Haemostasis and Thrombosis
1558:Journal of the American Society of Nephrology
8:
2273:Levy GG, Motto DG, Ginsburg D (July 2005).
1503:Levy GG, Motto DG, Ginsburg D (July 2005).
2903:
2889:
2881:
2508:
2494:
2486:
1498:
1496:
1494:
1492:
1490:
1488:
1486:
811:
786:cellular response to tumor necrosis factor
581:
369:
268:
165:
63:
2354:
2290:
2255:
2067:
2024:
1989:
1799:
1789:
1740:
1683:
1569:
1520:
3178:
1404:
1345:form as well, owing to its response to
1211:von Willebrand factor-cleaving protease
771:cellular response to lipopolysaccharide
1898:(September 2002). "ADAMTS13 and TTP".
18:
2850:Pregnancy-associated plasma protein A
2343:Journal of Thrombosis and Haemostasis
2056:Journal of Thrombosis and Haemostasis
2013:Journal of Thrombosis and Haemostasis
1672:Journal of Thrombosis and Haemostasis
766:cellular response to interferon-gamma
333:
294:
289:
232:
191:
186:
7:
2428:Online Mendelian Inheritance in Man
1859:International Journal of Hematology
1339:thrombotic thrombocytopenic purpura
1269:thrombotic thrombocytopenic purpura
1240:acts to reduce thrombus formation.
1228:(vWf), a large protein involved in
741:integrin-mediated signaling pathway
2383:The American Journal of Cardiology
2223:10.1053/j.seminhematol.2003.10.007
2194:10.1053/j.seminhematol.2003.10.002
2165:10.1053/j.seminhematol.2003.10.006
2136:10.1053/j.seminhematol.2003.10.004
2107:10.1053/j.seminhematol.2003.10.003
1991:10.1161/01.ATV.0000058401.34021.D4
1571:10.1097/01.ASN.0000060805.04118.4C
1273:microangiopathic hemolytic anemias
1267:Since 1982 it had been known that
1079:
1050:
1012:
979:
955:
936:
910:
887:
861:
842:
781:cellular response to interleukin-4
551:
469:
407:
386:
14:
1337:, the recurring familial form of
1291:was associated with formation of
736:response to tumor necrosis factor
3181:
2356:10.1111/j.1538-7836.2005.01360.x
2069:10.1046/j.1538-7836.2003.00170.x
2026:10.1046/j.1538-7836.2003.00169.x
1912:10.1097/00062752-200209000-00001
1359:Finally, since the link between
555:
317:
310:
304:
281:
216:
209:
203:
178:
27:
701:glycoprotein metabolic process
566:More reference expression data
535:More reference expression data
427:right hemisphere of cerebellum
1:
2395:10.1016/j.amjcard.2007.03.095
1937:Journal of Molecular Medicine
1900:Current Opinion in Hematology
1842:10.1016/S1357-2725(00)00061-3
1367:was proven to be due to high
629:metalloendopeptidase activity
302:
201:
2855:Bone morphogenetic protein 1
1791:10.1371/journal.pone.0179258
1742:10.1182/blood-2015-05-643338
1204:pondin type 1 motif, member
711:response to interferon-gamma
3204:Genes on human chromosome 9
751:response to toxic substance
660:endoplasmic reticulum lumen
3230:
2454:gene details page in the
2318:Current Hematology Reports
2292:10.1182/blood-2004-10-4097
1642:10.1016/j.blre.2014.04.003
1522:10.1182/blood-2004-10-4097
1232:. It is secreted into the
3059:Michaelis–Menten kinetics
2682:Matrix metalloproteinases
2437:Secreted protein database
1949:10.1007/s00109-002-0369-8
1473:"Mouse PubMed Reference:"
1455:"Human PubMed Reference:"
1164:
1159:
1155:
1148:
1132:
1119:Chr 9: 133.41 – 133.46 Mb
1113:
1086:
1057:
1046:
1019:
986:
975:
962:
958:
943:
939:
930:
917:
913:
894:
890:
881:
868:
864:
849:
845:
836:
821:
814:
810:
794:
761:response to potassium ion
756:peptide catabolic process
706:response to interleukin-4
639:metallopeptidase activity
584:
580:
563:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
2951:Diffusion-limited enzyme
2865:Insulin-degrading enzyme
2050:Remuzzi G (April 2003).
1335:Upshaw Schulman Syndrome
1196:etalloproteinase with a
2337:Dong JF (August 2005).
1321:domain and one or more
1282:at position 1605 and a
2211:Seminars in Hematology
2182:Seminars in Hematology
2153:Seminars in Hematology
2124:Seminars in Hematology
2095:Seminars in Hematology
2007:Tsai HM (April 2003).
1972:Tsai HM (March 2003).
1607:10.1053/beha.2001.0142
1552:Tsai HM (April 2003).
1381:von Willebrand disease
1126:Chr 2: 26.86 – 26.9 Mb
604:endopeptidase activity
521:superior frontal gyrus
16:Metalloprotease enzyme
3044:Eadie–Hofstee diagram
2977:Allosteric regulation
2840:Procollagen peptidase
2521:metalloendopeptidases
1894:Zheng X, Majerus EM,
1361:aortic valve stenosis
1226:von Willebrand factor
513:primary visual cortex
447:primary visual cortex
3054:Lineweaver–Burk plot
2448:genome location and
746:cell-matrix adhesion
680:extracellular matrix
665:extracellular region
296:Chromosome 2 (mouse)
194:Chromosome 9 (human)
158:ADAMTS13 - orthologs
67:List of PDB id codes
40:Available structures
2456:UCSC Genome Browser
1782:2017PLoSO..1279258D
731:platelet activation
675:extracellular space
599:calcium ion binding
423:right lobe of liver
3013:Enzyme superfamily
2946:Enzyme promiscuity
2275:"ADAMTS13 turns 3"
1871:10.1007/BF02981975
1505:"ADAMTS13 turns 3"
1271:(TTP), one of the
1255:maps to the ninth
920:ENSMUSG00000014852
716:protein processing
689:Biological process
653:Cellular component
634:hydrolase activity
619:peptidase activity
592:Molecular function
509:hippocampus proper
435:right frontal lobe
431:right uterine tube
3169:
3168:
2878:
2877:
2257:10.1159/000083839
1685:10.1111/jth.13032
1175:
1174:
1171:
1170:
1144:
1143:
1109:
1108:
1076:
1075:
1042:
1041:
1009:
1008:
971:
970:
952:
951:
926:
925:
907:
906:
877:
876:
858:
857:
806:
805:
776:response to amine
721:blood coagulation
609:metal ion binding
576:
575:
572:
571:
541:
540:
528:
527:
466:
465:
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
3221:
3186:
3185:
3177:
3049:Hanes–Woolf plot
2992:Enzyme activator
2987:Enzyme inhibitor
2961:Enzyme catalysis
2905:
2898:
2891:
2882:
2545:Alpha secretases
2510:
2503:
2496:
2487:
2406:
2376:
2358:
2333:
2312:
2294:
2269:
2259:
2234:
2205:
2176:
2147:
2118:
2089:
2071:
2046:
2028:
2003:
1993:
1968:
1931:
1890:
1853:
1814:
1813:
1803:
1793:
1761:
1755:
1754:
1744:
1720:
1714:
1713:
1687:
1669:
1660:
1654:
1653:
1625:
1619:
1618:
1590:
1584:
1583:
1573:
1549:
1543:
1542:
1524:
1500:
1481:
1480:
1469:
1463:
1462:
1451:
1445:
1435:
1424:
1414:
1373:Heyde's syndrome
1209:)—also known as
1157:
1156:
1128:
1121:
1104:
1080:
1071:
1051:
1047:RefSeq (protein)
1037:
1013:
1004:
980:
956:
937:
911:
888:
862:
843:
812:
644:zinc ion binding
614:integrin binding
582:
568:
559:
552:
537:
477:
475:Top expressed in
470:
415:
413:Top expressed in
408:
387:
370:
360:
347:
336:
321:
314:
308:
297:
285:
269:
259:
246:
235:
220:
213:
207:
196:
182:
166:
160:
111:
104:
81:
64:
58:
37:
36:
31:
19:
3229:
3228:
3224:
3223:
3222:
3220:
3219:
3218:
3194:
3193:
3192:
3180:
3172:
3170:
3165:
3077:Oxidoreductases
3063:
3039:Enzyme kinetics
3027:
3023:List of enzymes
2996:
2965:
2936:Catalytic triad
2914:
2909:
2879:
2874:
2823:
2676:
2531:
2514:
2483:
2414:
2409:
2379:
2336:
2315:
2272:
2250:(5–6): 417–21.
2237:
2208:
2179:
2150:
2121:
2092:
2049:
2006:
1971:
1934:
1893:
1856:
1827:
1823:
1821:Further reading
1818:
1817:
1776:(6): e0179258.
1763:
1762:
1758:
1735:(25): 2739–46.
1722:
1721:
1717:
1678:(8): 1396–404.
1667:
1662:
1661:
1657:
1627:
1626:
1622:
1592:
1591:
1587:
1551:
1550:
1546:
1502:
1501:
1484:
1471:
1470:
1466:
1453:
1452:
1448:
1436:
1427:
1415:
1406:
1401:
1389:
1331:
1329:Role in disease
1311:
1265:
1246:
1219:metalloprotease
1166:View/Edit Mouse
1161:View/Edit Human
1124:
1117:
1114:Location (UCSC)
1100:
1096:
1092:
1088:
1067:
1063:
1059:
1033:
1029:
1025:
1021:
1000:
996:
992:
988:
901:ENSG00000281244
899:
897:ENSG00000160323
790:
684:
648:
624:protein binding
564:
533:
524:
519:
515:
511:
507:
503:
499:
495:
491:
487:
473:
462:
459:Brodmann area 9
457:
453:
451:pituitary gland
449:
445:
441:
437:
433:
429:
425:
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
73:
51:
17:
12:
11:
5:
3227:
3225:
3217:
3216:
3211:
3206:
3196:
3195:
3191:
3190:
3167:
3166:
3164:
3163:
3150:
3137:
3124:
3111:
3098:
3085:
3071:
3069:
3065:
3064:
3062:
3061:
3056:
3051:
3046:
3041:
3035:
3033:
3029:
3028:
3026:
3025:
3020:
3015:
3010:
3004:
3002:
3001:Classification
2998:
2997:
2995:
2994:
2989:
2984:
2979:
2973:
2971:
2967:
2966:
2964:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2922:
2920:
2916:
2915:
2910:
2908:
2907:
2900:
2893:
2885:
2876:
2875:
2873:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2831:
2829:
2825:
2824:
2822:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2720:
2719:
2714:
2704:
2703:
2702:
2697:
2686:
2684:
2678:
2677:
2675:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2568:
2567:
2562:
2557:
2552:
2541:
2539:
2533:
2532:
2515:
2513:
2512:
2505:
2498:
2490:
2481:
2480:
2459:
2440:
2434:
2425:
2413:
2412:External links
2410:
2408:
2407:
2377:
2334:
2313:
2270:
2235:
2206:
2177:
2148:
2119:
2090:
2047:
2004:
1969:
1943:(10): 639–47.
1932:
1891:
1854:
1824:
1822:
1819:
1816:
1815:
1756:
1715:
1655:
1620:
1585:
1564:(4): 1072–81.
1544:
1482:
1464:
1446:
1425:
1403:
1402:
1400:
1397:
1396:
1395:
1388:
1385:
1365:angiodysplasia
1347:plasmapheresis
1330:
1327:
1323:thrombospondin
1310:
1307:
1264:
1261:
1245:
1242:
1230:blood clotting
1173:
1172:
1169:
1168:
1163:
1153:
1152:
1146:
1145:
1142:
1141:
1139:
1137:
1130:
1129:
1122:
1115:
1111:
1110:
1107:
1106:
1084:
1083:
1077:
1074:
1073:
1055:
1054:
1048:
1044:
1043:
1040:
1039:
1017:
1016:
1010:
1007:
1006:
984:
983:
977:
973:
972:
969:
968:
960:
959:
953:
950:
949:
941:
940:
934:
928:
927:
924:
923:
915:
914:
908:
905:
904:
892:
891:
885:
879:
878:
875:
874:
866:
865:
859:
856:
855:
847:
846:
840:
834:
833:
828:
823:
819:
818:
808:
807:
804:
803:
792:
791:
789:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
692:
690:
686:
685:
683:
682:
677:
672:
667:
662:
656:
654:
650:
649:
647:
646:
641:
636:
631:
626:
621:
616:
611:
606:
601:
595:
593:
589:
588:
578:
577:
574:
573:
570:
569:
561:
560:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3226:
3215:
3212:
3210:
3207:
3205:
3202:
3201:
3199:
3189:
3184:
3179:
3175:
3161:
3157:
3156:
3151:
3148:
3144:
3143:
3138:
3135:
3131:
3130:
3125:
3122:
3118:
3117:
3112:
3109:
3105:
3104:
3099:
3096:
3092:
3091:
3086:
3083:
3079:
3078:
3073:
3072:
3070:
3066:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3036:
3034:
3030:
3024:
3021:
3019:
3018:Enzyme family
3016:
3014:
3011:
3009:
3006:
3005:
3003:
2999:
2993:
2990:
2988:
2985:
2983:
2982:Cooperativity
2980:
2978:
2975:
2974:
2972:
2968:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2941:Oxyanion hole
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2923:
2921:
2917:
2913:
2906:
2901:
2899:
2894:
2892:
2887:
2886:
2883:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2832:
2830:
2826:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2718:
2715:
2713:
2710:
2709:
2708:
2705:
2701:
2698:
2696:
2693:
2692:
2691:
2688:
2687:
2685:
2683:
2679:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2547:
2546:
2543:
2542:
2540:
2538:
2537:ADAM proteins
2534:
2529:
2526:
2522:
2518:
2511:
2506:
2504:
2499:
2497:
2492:
2491:
2488:
2484:
2478:
2474:
2473:
2468:
2464:
2460:
2457:
2453:
2452:
2447:
2446:
2441:
2438:
2435:
2433:
2429:
2426:
2424:
2420:
2416:
2415:
2411:
2404:
2400:
2396:
2392:
2389:(5): 758–63.
2388:
2384:
2381:infarction".
2378:
2374:
2370:
2366:
2362:
2357:
2352:
2349:(8): 1710–6.
2348:
2344:
2340:
2335:
2331:
2327:
2323:
2319:
2314:
2310:
2306:
2302:
2298:
2293:
2288:
2284:
2280:
2276:
2271:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2236:
2232:
2228:
2224:
2220:
2216:
2212:
2207:
2203:
2199:
2195:
2191:
2187:
2183:
2178:
2174:
2170:
2166:
2162:
2158:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2096:
2091:
2087:
2083:
2079:
2075:
2070:
2065:
2061:
2057:
2053:
2048:
2044:
2040:
2036:
2032:
2027:
2022:
2019:(4): 625–31.
2018:
2014:
2010:
2005:
2001:
1997:
1992:
1987:
1984:(3): 388–96.
1983:
1979:
1975:
1970:
1966:
1962:
1958:
1954:
1950:
1946:
1942:
1938:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1906:(5): 389–94.
1905:
1901:
1897:
1892:
1888:
1884:
1880:
1876:
1872:
1868:
1864:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1826:
1825:
1820:
1811:
1807:
1802:
1797:
1792:
1787:
1783:
1779:
1775:
1771:
1767:
1760:
1757:
1752:
1748:
1743:
1738:
1734:
1730:
1726:
1719:
1716:
1711:
1707:
1703:
1699:
1695:
1694:10044/1/26935
1691:
1686:
1681:
1677:
1673:
1666:
1659:
1656:
1651:
1647:
1643:
1639:
1636:(4): 167–78.
1635:
1631:
1630:Blood Reviews
1624:
1621:
1616:
1612:
1608:
1604:
1601:(2): 437–54.
1600:
1596:
1589:
1586:
1581:
1577:
1572:
1567:
1563:
1559:
1555:
1548:
1545:
1540:
1536:
1532:
1528:
1523:
1518:
1514:
1510:
1506:
1499:
1497:
1495:
1493:
1491:
1489:
1487:
1483:
1478:
1474:
1468:
1465:
1460:
1456:
1450:
1447:
1443:
1439:
1434:
1432:
1430:
1426:
1422:
1418:
1413:
1411:
1409:
1405:
1398:
1394:
1391:
1390:
1386:
1384:
1382:
1378:
1374:
1370:
1366:
1362:
1357:
1354:
1352:
1348:
1344:
1340:
1336:
1328:
1326:
1324:
1320:
1316:
1315:ADAMTS family
1308:
1306:
1304:
1301:
1297:
1294:
1290:
1285:
1281:
1276:
1274:
1270:
1262:
1260:
1258:
1254:
1251:
1243:
1241:
1239:
1235:
1231:
1227:
1224:that cleaves
1223:
1220:
1216:
1213:(VWFCP)—is a
1212:
1208:
1207:
1203:
1199:
1195:
1191:
1187:
1184:
1179:
1167:
1162:
1158:
1154:
1151:
1147:
1140:
1138:
1135:
1131:
1127:
1123:
1120:
1116:
1112:
1105:
1103:
1099:
1095:
1091:
1085:
1081:
1078:
1072:
1070:
1066:
1062:
1056:
1052:
1049:
1045:
1038:
1036:
1032:
1028:
1024:
1018:
1014:
1011:
1005:
1003:
999:
995:
991:
985:
981:
978:
976:RefSeq (mRNA)
974:
967:
966:
961:
957:
954:
948:
947:
942:
938:
935:
933:
929:
922:
921:
916:
912:
909:
903:
902:
898:
893:
889:
886:
884:
880:
873:
872:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
832:
829:
827:
824:
820:
817:
813:
809:
802:
798:
793:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
693:
691:
688:
687:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
657:
655:
652:
651:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
596:
594:
591:
590:
587:
586:Gene ontology
583:
579:
567:
562:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
458:
455:apex of heart
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3155:Translocases
3152:
3139:
3126:
3113:
3100:
3090:Transferases
3087:
3074:
2931:Binding site
2690:Collagenases
2671:
2482:
2470:
2450:
2444:
2386:
2382:
2346:
2342:
2324:(3): 167–9.
2321:
2317:
2282:
2278:
2247:
2243:
2214:
2210:
2188:(1): 34–40.
2185:
2181:
2159:(1): 24–33.
2156:
2152:
2130:(1): 15–23.
2127:
2123:
2098:
2094:
2062:(4): 632–4.
2059:
2055:
2016:
2012:
1981:
1977:
1940:
1936:
1903:
1899:
1865:(1): 25–34.
1862:
1858:
1836:(1): 33–44.
1833:
1829:
1773:
1769:
1759:
1732:
1728:
1718:
1675:
1671:
1658:
1633:
1629:
1623:
1598:
1594:
1588:
1561:
1557:
1547:
1512:
1508:
1476:
1467:
1458:
1449:
1369:shear stress
1358:
1355:
1332:
1312:
1296:microthrombi
1277:
1266:
1249:
1247:
1237:
1217:-containing
1210:
1205:
1201:
1197:
1193:
1189:
1185:
1182:
1181:
1177:
1176:
1102:NP_001277394
1098:NP_001277393
1094:NP_001277392
1090:NP_001001322
1087:
1058:
1035:NM_001290465
1031:NM_001290464
1027:NM_001290463
1023:NM_001001322
1020:
987:
963:
944:
918:
895:
869:
850:
830:
825:
670:cell surface
439:right testis
397:
390:
255:133,459,402
242:133,414,358
117:External IDs
72:
2926:Active site
2860:Lysostaphin
2845:Thermolysin
2707:Gelatinases
2285:(1): 11–7.
2217:(1): 83–9.
2101:(1): 4–14.
1515:(1): 11–7.
1383:(type 2a).
1319:disintegrin
1188:isintegrin
726:proteolysis
497:bone marrow
443:left testis
356:26,899,640
343:26,863,428
335:2|2 A3
95:Identifiers
3198:Categories
3129:Isomerases
3103:Hydrolases
2970:Regulation
2835:Neprilysin
1444:, May 2017
1423:, May 2017
1399:References
1343:autoimmune
1309:Proteomics
1303:antibodies
1284:methionine
1257:chromosome
696:hemostasis
401:(ortholog)
138:HomoloGene
3209:EC 3.4.24
3008:EC number
2517:Proteases
1896:Sadler JE
1263:Discovery
1069:NP_620596
1065:NP_620595
1061:NP_620594
1002:NM_139028
998:NM_139027
994:NM_139026
990:NM_139025
816:Orthologs
505:esophagus
146:GeneCards
3032:Kinetics
2956:Cofactor
2919:Activity
2870:ZMPSTE24
2672:ADAMTS13
2667:ADAMTS12
2662:ADAMTS10
2451:ADAMTS13
2445:ADAMTS13
2430:(OMIM):
2403:17719316
2373:33464866
2365:16102037
2330:15865866
2309:25645477
2301:15774620
2266:15692254
2231:14727263
2202:14727257
2173:14727256
2144:14727255
2115:14727254
2086:10742104
2078:12871391
2043:26485194
2035:12871390
2000:12615692
1965:24992893
1957:12395148
1928:19457473
1920:12172456
1887:19926816
1879:11843286
1850:11167130
1810:28591212
1770:PLOS ONE
1751:26511134
1702:26073931
1650:24825749
1615:11686108
1580:12660343
1539:25645477
1531:15774620
1440:–
1419:–
1387:See also
1377:bleeding
1351:epitopes
1293:platelet
1289:protease
1280:tyrosine
1259:(9q34).
1250:ADAMTS13
1244:Genetics
1238:ADAMTS13
1178:ADAMTS13
1150:Wikidata
795:Sources:
517:yolk sac
150:ADAMTS13
109:ADAMTS13
22:ADAMTS13
3188:Biology
3142:Ligases
2912:Enzymes
2657:ADAMTS9
2652:ADAMTS8
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2467:UniProt
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1801:5462472
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2794:MMP23B
2789:MMP23A
2622:ADAM33
2617:ADAM28
2612:ADAM23
2607:ADAM22
2602:ADAM18
2597:ADAM15
2592:ADAM12
2587:ADAM11
2565:ADAM19
2560:ADAM17
2555:ADAM10
2528:3.4.24
2472:Q76LX8
2442:Human
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547:BioGPS
501:embryo
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234:9q34.2
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2819:MMP28
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2809:MMP26
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2799:MMP24
2784:MMP21
2779:MMP20
2774:MMP19
2769:MMP17
2764:MMP16
2759:MMP15
2754:MMP14
2749:MMP13
2744:MMP12
2739:MMP11
2734:MMP10
2582:ADAM8
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2572:ADAM2
2550:ADAM9
2439:entry
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2305:S2CID
2279:Blood
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2039:S2CID
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1668:(PDF)
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2724:MMP3
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2700:MMP8
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2103:doi
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1945:doi
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