308:
285:
182:
207:
314:
213:
1298:. Comparative analysis of the primary protein sequence of ADRA2B across placentals also showed the high conservation of residues thought to be involved in agonist binding and in G protein–coupling. However, great variations are observed in the very long, third intracellular loop, with a polyglutamyl domain displaying pervasive length differences.
1249:
adrenergic receptor has been shown to be related to emotional memory in
Europeans and Africans. This variant also predisposed people who had it to focus more on negative aspects of a situation. This predisposition remained present in people with the variant gene who took a single dose of the
61:
2390:
Cayla C, Heinonen P, Viikari L, Schaak S, Snapir A, Bouloumié A, Karvonen MK, Pesonen U, Scheinin M, Paris H (Feb 2004). "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene".
1735:
Davis RA, Fechner GA, Sykes M, Garavelas A, Pass DM, Carroll AR, Addepalli R, Avery VM, Hooper JN, Quinn RJ (Mar 2009). "(-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the
Australian marine sponge, Acanthella costata".
2288:
Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, Trakada G, Spyropoulos K, Kalfarentzos F, Papavassiliou AG, Vagenakis AG, Flordellis CS (Jun 2003). "The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity".
1907:
Weinshank RL, Zgombick JM, Macchi M, Adham N, Lichtblau H, Branchek TA, Hartig PR (Nov 1990). "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor".
2326:
Chotani MA, Mitra S, Su BY, Flavahan S, Eid AH, Clark KR, Montague CR, Paris H, Handy DE, Flavahan NA (Jan 2004). "Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells".
1643:
Madsen O, Scally M, Douady CJ, Kao DJ, DeBry RW, Adkins R, Amrine HM, Stanhope MJ, de Jong WW, Springer MS (Feb 2001). "Parallel adaptive radiations in two major clades of placental mammals".
5293:
2220:"Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization"
1619:
1928:
Chang AC, Ho TF, Chang NC (Oct 1990). "In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans".
1517:
Todd RM, Müller DJ, Lee DH, Robertson A, Eaton T, Freeman N, Palombo DJ, Levine B, Anderson AK (2013). "Genes for emotion-enhanced remembering are linked to enhanced perceiving".
2547:
1813:"Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2"
2457:"Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study"
2074:
Okusa MD, Huang L, Momose-Hotokezaka A, Huynh LP, Mangrum AJ (Dec 1997). "Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors".
321:
220:
4759:
1866:"The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2"
3697:
3899:
3894:
3889:
3884:
4629:
5019:
5014:
2140:"Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects"
848:
2455:
Siitonen N, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M (Aug 2004).
5050:
4395:
2540:
829:
143:
5010:
3796:
3791:
5034:
4716:
4711:
4706:
3672:
5090:
3960:
3787:
1627:
4701:
3647:
1418:
5454:
3875:
3687:
3157:
2895:
2890:
2885:
2880:
2875:
2533:
1400:
2173:
Hein L, Altman JD, Kobilka BK (Nov 1999). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission".
4688:
3337:
2492:"Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene"
1192:
1784:
307:
4593:
3562:
1055:
1048:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5227:
3450:
3245:
3240:
3235:
2871:
284:
2255:"Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death"
2105:"The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes"
5044:
5039:
3979:
3974:
3055:
3050:
1456:
1439:
5223:
5130:
3984:
3230:
2985:
1387:
1366:
5079:
5074:
4608:
3849:
3844:
3692:
3541:
3536:
2357:"Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension"
1790:
1383:
206:
181:
58:
5459:
4613:
1362:
5070:
3410:
3405:
2641:
2631:
2621:
2616:
2611:
2010:
Petrash AC, Bylund DB (Jun 1986). "Alpha-2 adrenergic receptor subtypes indicated by yohimbine binding in human brain".
123:
1577:"Alpha 2B adrenoceptor genotype moderates effect of reboxetine on negative emotional memory bias in healthy volunteers"
1555:
4604:
3171:
3166:
2627:
2607:
320:
219:
2490:
Belfer I, Buzas B, Hipp H, Phillips G, Taubman J, Lorincz I, Evans C, Lipsky RH, Enoch MA, Max MB, Goldman D (2005).
3604:
3599:
3455:
3445:
3440:
3425:
3420:
3393:
3219:
3214:
3209:
3120:
2657:
2652:
2647:
2560:
1219:
1212:
1116:
313:
212:
3641:
3636:
3631:
3401:
3287:
3115:
3097:
3078:
3071:
2590:
5196:
5065:
5025:
4671:
3595:
3557:
3416:
3205:
3129:
3083:
2573:
2420:
Phares DA, Halverstadt AA, Shuldiner AR, Ferrell RE, Douglass LW, Ryan AS, Goldberg AP, Hagberg JM (May 2004).
2138:
Heinonen P, Koulu M, Pesonen U, Karvonen MK, Rissanen A, Laakso M, Valve R, Uusitupa M, Scheinin M (Jul 1999).
893:
131:
1274:
phylogenetic marker. This intronless gene has first been used to explore the phylogeny of the major groups of
3929:
3924:
3919:
3914:
3909:
3869:
3864:
3781:
3776:
3771:
3761:
3627:
3511:
3479:
3474:
3436:
3431:
3342:
3066:
874:
2041:"A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B"
3582:
3577:
3494:
3489:
3088:
2689:
2684:
1172:
1472:"A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans"
5127:
3965:
3949:
3944:
3939:
3905:
3860:
3757:
3620:
3615:
3567:
3470:
3465:
3252:
3136:
2979:
2974:
2969:
2958:
2953:
2948:
2943:
2694:
2679:
2556:
1239:
5177:
4835:
4147:
3970:
3955:
3821:
3816:
3811:
3532:
3485:
3162:
3141:
2926:
2921:
2916:
2911:
2906:
2525:
2182:
1970:
1824:
1652:
1223:
195:
1811:
Lomasney JW, Lorenz W, Allen LF, King K, Regan JW, Yang-Feng TL, Caron MG, Lefkowitz RJ (Jul 1990).
5000:
3935:
3826:
3610:
3573:
3038:
2667:
2599:
1796:
1339:
1120:
110:
1470:
de
Quervain DJ, Kolassa IT, Ertl V, Onyut PL, Neuner F, Elbert T, Papassotiropoulos A (Sep 2007).
5219:
4730:
4554:
3666:
3661:
3656:
3590:
2965:
2938:
2675:
2314:
2206:
1895:
1676:
1542:
1499:
1168:
155:
1031:
1010:
984:
963:
5085:
5029:
4675:
4405:
4400:
3855:
3552:
2901:
2513:
2478:
2443:
2408:
2378:
2343:
2306:
2276:
2241:
2198:
2161:
2126:
2091:
2062:
2027:
1998:
1945:
1916:
1887:
1852:
1763:
1717:
1668:
1606:
1534:
1491:
103:
51:
3880:
3802:
3652:
2503:
2468:
2433:
2400:
2368:
2335:
2298:
2266:
2231:
2190:
2151:
2116:
2083:
2052:
2019:
1988:
1978:
1937:
1877:
1842:
1832:
1753:
1745:
1707:
1660:
1596:
1588:
1526:
1483:
1295:
1230:
subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no
1196:
1164:
400:
331:
275:
230:
151:
5273:
5060:
4869:
4158:
3840:
3807:
3547:
2844:
2829:
2824:
2819:
2809:
2804:
2799:
2794:
2789:
1959:"Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype"
1712:
1695:
375:
2422:"Association between body fat response to exercise training and multilocus ADR genotypes"
2186:
1974:
1828:
1656:
1471:
5146:
4006:
3834:
3061:
2854:
2849:
2839:
2815:
2785:
2780:
2373:
2356:
1601:
1576:
1291:
1208:
2271:
2254:
1993:
1958:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
657:
652:
647:
642:
637:
632:
616:
611:
606:
601:
591:
5448:
5201:
4850:
4845:
4840:
3766:
3702:
2770:
2210:
2087:
2023:
1941:
1882:
1865:
1847:
1812:
1235:
1204:
578:
2318:
1899:
5123:
3521:
3515:
3125:
3110:
2933:
2700:
1957:
Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK (Sep 1988).
1680:
1592:
1546:
393:
172:
2253:
Snapir A, Mikkelsson J, Perola M, Penttilä A, Scheinin M, Karhunen PJ (Jan 2003).
1503:
135:
159:
114:, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B
2339:
1423:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1405:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1271:
1963:
Proceedings of the
National Academy of Sciences of the United States of America
1817:
Proceedings of the
National Academy of Sciences of the United States of America
476:
5425:
5341:
4568:
2508:
2491:
2473:
2456:
2404:
2302:
1749:
1287:
1251:
292:
189:
139:
2121:
2104:
2057:
2040:
1530:
5134:
5055:
2577:
1983:
1837:
1327:
1283:
1279:
1132:
793:
596:
536:
414:
359:
346:
258:
245:
147:
2517:
2482:
2447:
2412:
2382:
2347:
2310:
2280:
2245:
2236:
2219:
2202:
2165:
2156:
2139:
2130:
1767:
1721:
1672:
1610:
1538:
1495:
2095:
2066:
2031:
2002:
1949:
1920:
1891:
1856:
1095:
1090:
5359:
5337:
1322:
1079:
938:
919:
764:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
2438:
2421:
2355:
Von Wowern F, Bengtsson K, Lindblad U, Råstam L, Melander O (Mar 2004).
4430:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
3751:
3746:
3741:
3736:
1758:
1275:
1231:
1136:
905:
860:
80:
17:
5312:
5307:
5302:
5297:
5287:
5282:
5277:
5268:
5213:
5208:
5170:
5165:
5160:
5005:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4823:
4818:
4813:
4808:
4745:
4740:
4735:
4643:
4588:
4583:
4578:
4549:
4530:
4525:
4520:
4515:
4510:
4505:
4500:
4495:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4425:
4420:
4415:
4410:
4390:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
3731:
3726:
3721:
3716:
3681:
3372:
3195:
3189:
2759:
2754:
2744:
2739:
1664:
1215:
1188:
1063:
815:
1694:
Madsen O, Willemsen D, Ursing BM, Arnason U, de Jong WW (Dec 2002).
1696:"Molecular evolution of the mammalian alpha 2B adrenergic receptor"
1487:
5408:
5099:
5094:
4896:
4891:
4886:
4881:
4857:
4803:
4798:
4793:
4638:
4633:
4623:
4618:
4559:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
3711:
3676:
3526:
3366:
3361:
3356:
3351:
3346:
3332:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3281:
3276:
3271:
3266:
3261:
3256:
3224:
3184:
3179:
3102:
3014:
3009:
3004:
2999:
2994:
2989:
2749:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2194:
1227:
739:
adenylate cyclase-activating adrenergic receptor signaling pathway
778:
774:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
4781:
4774:
4769:
4764:
4573:
4563:
4185:
4180:
4175:
4170:
3830:
3706:
3200:
2328:
American
Journal of Physiology. Heart and Circulatory Physiology
1124:
127:
5334:
5121:
4669:
2571:
2529:
4598:
1151:-adrenergic receptors include 3 highly homologous subtypes: α
1575:
Gibbs AA, Bautista CE, Mowlem FD, Naudts KH, Duka T (2013).
2039:
Klein U, Ramirez MT, Kobilka BK, von
Zastrow M (Aug 1997).
704:
regulation of vascular associated smooth muscle contraction
2103:
Prezeau L, Richman JG, Edwards SW, Limbird LE (May 1999).
1222:; this polymorphic form is also associated with reduced
709:
positive regulation of uterine smooth muscle contraction
383:
1556:"Genes predispose some people to focus on the negative"
2218:
Small KM, Brown KM, Forbes SL, Liggett SB (Feb 2001).
1457:"OrthoMaM phylogenetic marker: ADRA2B coding sequence"
1620:"Genetic variation alters efficacy of antidepressant"
1440:"Entrez Gene: ADRA2B adrenergic, alpha-2B-, receptor"
1163:. These receptors have a critical role in regulating
548:
2144:
The
Journal of Clinical Endocrinology and Metabolism
5418:
5352:
5187:
5145:
4991:
4868:
4687:
4540:
4157:
4005:
3998:
3504:
3392:
3385:
3150:
3037:
3028:
2864:
2769:
2666:
2598:
2589:
1930:
Biochemical and Biophysical Research Communications
1024:
1003:
977:
956:
1379:
1377:
1375:
1358:
1356:
1354:
1254:, but was weakened in people without the variant.
330:
229:
1282:orders are distributed into four major clades:
749:negative regulation of norepinephrine secretion
27:Protein-coding gene in the species Homo sapiens
1384:GRCm38: Ensembl release 89: ENSMUSG00000058620
1187:subtype, which was observed to associate with
2541:
2259:Journal of the American College of Cardiology
744:positive regulation of neuron differentiation
8:
729:negative regulation of epinephrine secretion
684:G protein-coupled receptor signaling pathway
1626:(Press release). 2013-10-22. Archived from
1363:GRCh38: Ensembl release 89: ENSG00000274286
5349:
5331:
5142:
5118:
4684:
4666:
4002:
3389:
3034:
2595:
2586:
2568:
2548:
2534:
2526:
1451:
1449:
789:
574:
371:
270:
167:
69:
2507:
2472:
2437:
2372:
2270:
2235:
2155:
2120:
2056:
1992:
1982:
1881:
1846:
1836:
1757:
1711:
1600:
1434:
1432:
1350:
724:activation of protein kinase B activity
714:regulation of smooth muscle contraction
3698:Luteinizing hormone/choriogonadotropin
1127:encoding this receptor has the symbol
29:
4702:Brain-specific angiogenesis inhibitor
1713:10.1093/oxfordjournals.molbev.a004040
694:adrenergic receptor signaling pathway
689:positive regulation of blood pressure
648:integral component of plasma membrane
335:
296:
291:
234:
193:
188:
7:
1738:Bioorganic & Medicinal Chemistry
2224:The Journal of Biological Chemistry
2109:The Journal of Biological Chemistry
2045:The Journal of Biological Chemistry
1211:, was identified to have decreased
1193:guanine nucleotide exchange protein
1171:and from adrenergic neurons in the
754:positive regulation of MAPK cascade
602:alpha2-adrenergic receptor activity
592:G protein-coupled receptor activity
2374:10.1161/01.HYP.0000116224.51189.80
2076:The American Journal of Physiology
1864:McClue SJ, Milligan G (Sep 1990).
1560:The University of British Columbia
1021:
1000:
974:
953:
929:
910:
884:
865:
839:
820:
653:intracellular anatomical structure
553:
471:
409:
388:
25:
1278:, and contributed to reveal that
5051:Growth-hormone-releasing hormone
2088:10.1152/ajprenal.1997.273.6.F883
1199:. A polymorphic variant of the α
1195:that functions in regulation of
1135:have been identified in several
319:
312:
306:
283:
218:
211:
205:
180:
5011:Corticotropin-releasing hormone
1700:Molecular Biology and Evolution
3673:Gonadotropin-releasing hormone
1593:10.1523/JNEUROSCI.2124-13.2013
1266:gene (sometimes referenced as
1218:-mediated phosphorylation and
699:regulation of vasoconstriction
633:integral component of membrane
537:More reference expression data
1:
5091:Vasoactive intestinal peptide
3961:Thyrotropin-releasing hormone
2272:10.1016/S0735-1097(02)02702-X
1250:noradrenergic antidepressant
304:
203:
2024:10.1016/0024-3205(86)90212-2
1942:10.1016/0006-291X(90)90748-C
1883:10.1016/0014-5793(90)81209-7
1109:alpha-2B adrenergic receptor
607:adrenergic receptor activity
5455:Genes on human chromosome 2
3876:Prolactin-releasing peptide
2561:G protein-coupled receptors
2340:10.1152/ajpheart.00268.2003
2291:Clinical Autonomic Research
1245:A deletion variant of the α
445:subcutaneous adipose tissue
5476:
1795:gene details page in the
1270:) is used in animals as a
1213:G protein-coupled receptor
1117:G-protein coupled receptor
597:signal transducer activity
5348:
5330:
5141:
5117:
4683:
4665:
2585:
2567:
2509:10.1007/s10038-004-0211-y
2496:Journal of Human Genetics
2474:10.1007/s00125-004-1462-z
2405:10.1016/j.bcp.2003.09.029
2303:10.1007/s10286-003-0087-5
1750:10.1016/j.bmc.2009.01.065
1419:"Mouse PubMed Reference:"
1401:"Human PubMed Reference:"
1119:. It is a subtype of the
1094:
1089:
1085:
1078:
1062:
1056:Chr 2: 127.21 – 127.21 Mb
1043:
1028:
1007:
996:
981:
960:
949:
936:
932:
917:
913:
904:
891:
887:
872:
868:
859:
846:
842:
827:
823:
814:
799:
792:
788:
772:
577:
573:
561:
556:
547:
534:
483:
474:
421:
412:
382:
374:
370:
353:
340:
303:
282:
273:
269:
252:
239:
202:
179:
170:
166:
121:
118:
108:
101:
96:
77:
72:
55:
50:
45:
41:
37:
32:
5197:Calcium-sensing receptor
5066:Methuselah-like proteins
2393:Biochemical Pharmacology
2122:10.1074/jbc.274.19.13462
2058:10.1074/jbc.272.31.19099
1624:Society for Neuroscience
1531:10.1177/0956797613492423
759:receptor transactivation
3343:Sphingosine-1-phosphate
3231:Hydroxycarboxylic acids
1984:10.1073/pnas.85.17.6301
1838:10.1073/pnas.87.13.5094
1203:subtype, which lacks 3
1183:This gene encodes the α
1049:Chr 2: 96.11 – 96.12 Mb
5224:Metabotropic glutamate
2237:10.1074/jbc.M008118200
2157:10.1210/jcem.84.7.5818
1909:Molecular Pharmacology
1240:untranslated sequences
1173:central nervous system
3253:Lysophosphatidic acid
2557:Cell surface receptor
1207:from a glutamic acid
1179:Clinical significance
5460:Adrenergic receptors
5178:Vomeronasal receptor
4148:Vomeronasal receptor
1789:genome location and
1312:(−)-Dibromophakellin
1224:basal metabolic rate
1115:adrenoceptor), is a
515:hepatobiliary system
429:gastrocnemius muscle
337:2 F1|2 61.95 cM
298:Chromosome 2 (mouse)
196:Chromosome 2 (human)
73:List of PDB id codes
46:Available structures
5071:Parathyroid hormone
3031:signaling molecules
2439:10.1038/oby.2004.97
2187:1999Natur.402..181H
2082:(6 Pt 2): F883–91.
1975:1988PNAS...85.6301R
1829:1990PNAS...87.5094L
1797:UCSC Genome Browser
1657:2001Natur.409..610M
1562:. October 10, 2013.
1476:Nature Neuroscience
1340:Adrenergic receptor
1121:adrenergic receptor
734:cell-cell signaling
719:signal transduction
674:platelet activation
612:epinephrine binding
437:right lobe of liver
5220:Glutamate receptor
4605:Protease-activated
1169:sympathetic nerves
1123:family. The human
894:ENSMUSG00000058620
667:Biological process
626:Cellular component
585:Molecular function
160:ADRA2B - orthologs
5442:
5441:
5438:
5437:
5434:
5433:
5326:
5325:
5322:
5321:
5113:
5112:
5109:
5108:
4661:
4660:
4657:
4656:
4653:
4652:
3994:
3993:
3381:
3380:
3024:
3023:
2051:(31): 19099–102.
1105:
1104:
1101:
1100:
1074:
1073:
1039:
1038:
1018:
1017:
992:
991:
971:
970:
945:
944:
926:
925:
900:
899:
881:
880:
855:
854:
836:
835:
784:
783:
569:
568:
565:
564:
543:
542:
530:
529:
468:
467:
366:
365:
265:
264:
92:
91:
88:
87:
56:Ortholog search:
16:(Redirected from
5467:
5350:
5332:
5143:
5119:
4685:
4667:
4003:
3390:
3288:Lysophospholipid
3035:
2596:
2591:Neurotransmitter
2587:
2569:
2550:
2543:
2536:
2527:
2521:
2511:
2486:
2476:
2451:
2441:
2426:Obesity Research
2416:
2386:
2376:
2351:
2322:
2284:
2274:
2249:
2239:
2214:
2169:
2159:
2134:
2124:
2099:
2070:
2060:
2035:
2006:
1996:
1986:
1953:
1924:
1903:
1885:
1860:
1850:
1840:
1772:
1771:
1761:
1732:
1726:
1725:
1715:
1691:
1685:
1684:
1665:10.1038/35054544
1640:
1634:
1631:
1617:Lay summary in:
1614:
1604:
1572:
1566:
1563:
1553:Lay summary in:
1550:
1514:
1508:
1507:
1467:
1461:
1460:
1453:
1444:
1443:
1436:
1427:
1426:
1415:
1409:
1408:
1397:
1391:
1381:
1370:
1360:
1296:Euarchontoglires
1165:neurotransmitter
1087:
1086:
1058:
1051:
1034:
1022:
1013:
1001:
997:RefSeq (protein)
987:
975:
966:
954:
930:
911:
885:
866:
840:
821:
790:
679:female pregnancy
575:
554:
539:
523:secondary oocyte
479:
477:Top expressed in
472:
417:
415:Top expressed in
410:
389:
372:
362:
349:
338:
323:
316:
310:
299:
287:
271:
261:
248:
237:
222:
215:
209:
198:
184:
168:
162:
113:
106:
83:
70:
64:
43:
42:
30:
21:
5475:
5474:
5470:
5469:
5468:
5466:
5465:
5464:
5445:
5444:
5443:
5430:
5414:
5344:
5318:
5205:
5183:
5137:
5105:
4987:
4864:
4679:
4649:
4536:
4153:
3990:
3596:Cholecystokinin
3500:
3377:
3206:Free fatty acid
3146:
3030:
3029:Metabolites and
3020:
2860:
2765:
2662:
2581:
2563:
2554:
2524:
2489:
2454:
2419:
2389:
2354:
2325:
2287:
2252:
2217:
2181:(6758): 181–4.
2172:
2137:
2115:(19): 13462–9.
2102:
2073:
2038:
2018:(23): 2129–37.
2009:
1956:
1927:
1906:
1863:
1810:
1806:
1804:Further reading
1780:
1775:
1744:(6): 2497–500.
1734:
1733:
1729:
1706:(12): 2150–60.
1693:
1692:
1688:
1651:(6820): 610–4.
1642:
1641:
1637:
1618:
1587:(43): 17023–8.
1574:
1573:
1569:
1554:
1525:(11): 2244–53.
1516:
1515:
1511:
1469:
1468:
1464:
1455:
1454:
1447:
1438:
1437:
1430:
1417:
1416:
1412:
1399:
1398:
1394:
1382:
1373:
1361:
1352:
1348:
1336:
1304:
1260:
1248:
1220:desensitization
1202:
1186:
1181:
1162:
1158:
1154:
1150:
1145:
1114:
1096:View/Edit Mouse
1091:View/Edit Human
1054:
1047:
1044:Location (UCSC)
1030:
1009:
983:
962:
875:ENSG00000274286
768:
662:
638:plasma membrane
621:
617:protein binding
535:
526:
521:
517:
513:
509:
505:
501:
497:
493:
491:proximal tubule
489:
475:
464:
459:
457:ascending aorta
455:
451:
449:muscle of thigh
447:
443:
439:
435:
431:
427:
413:
357:
344:
336:
326:
325:
324:
317:
297:
274:Gene location (
256:
243:
235:
225:
224:
223:
216:
194:
171:Gene location (
122:
109:
102:
79:
57:
28:
23:
22:
15:
12:
11:
5:
5473:
5471:
5463:
5462:
5457:
5447:
5446:
5440:
5439:
5436:
5435:
5432:
5431:
5429:
5428:
5422:
5420:
5416:
5415:
5413:
5412:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5366:
5356:
5354:
5346:
5345:
5335:
5328:
5327:
5324:
5323:
5320:
5319:
5317:
5316:
5310:
5305:
5300:
5291:
5285:
5280:
5271:
5266:
5260:
5255:
5250:
5245:
5240:
5235:
5230:
5217:
5211:
5203:
5199:
5193:
5191:
5185:
5184:
5182:
5181:
5175:
5174:
5173:
5168:
5163:
5152:
5150:
5139:
5138:
5122:
5115:
5114:
5111:
5110:
5107:
5106:
5104:
5103:
5097:
5088:
5083:
5077:
5068:
5063:
5058:
5053:
5048:
5042:
5037:
5032:
5023:
5017:
5008:
5003:
4997:
4995:
4989:
4988:
4986:
4985:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4874:
4872:
4866:
4865:
4863:
4862:
4861:
4860:
4855:
4854:
4853:
4848:
4843:
4828:
4827:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4786:
4785:
4784:
4779:
4778:
4777:
4772:
4767:
4752:
4751:
4750:
4749:
4748:
4743:
4738:
4723:
4722:
4721:
4720:
4719:
4714:
4709:
4693:
4691:
4681:
4680:
4670:
4663:
4662:
4659:
4658:
4655:
4654:
4651:
4650:
4648:
4647:
4641:
4636:
4627:
4621:
4616:
4611:
4602:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4557:
4552:
4550:Adrenomedullin
4546:
4544:
4538:
4537:
4535:
4534:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4163:
4161:
4155:
4154:
4152:
4151:
4145:
4144:
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4012:
4010:
4000:
3996:
3995:
3992:
3991:
3989:
3988:
3982:
3977:
3968:
3963:
3958:
3953:
3947:
3942:
3933:
3927:
3922:
3917:
3912:
3903:
3897:
3892:
3887:
3878:
3873:
3867:
3858:
3853:
3847:
3838:
3824:
3819:
3814:
3805:
3800:
3794:
3785:
3779:
3774:
3769:
3764:
3755:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3700:
3695:
3690:
3685:
3679:
3670:
3664:
3659:
3650:
3645:
3639:
3634:
3628:Formyl peptide
3625:
3624:
3623:
3618:
3608:
3602:
3593:
3588:
3587:
3586:
3580:
3571:
3565:
3560:
3550:
3545:
3539:
3530:
3524:
3518:
3508:
3506:
3502:
3501:
3499:
3498:
3492:
3483:
3477:
3468:
3459:
3453:
3448:
3443:
3434:
3429:
3423:
3414:
3408:
3398:
3396:
3387:
3383:
3382:
3379:
3378:
3376:
3375:
3370:
3364:
3359:
3354:
3349:
3340:
3335:
3330:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3285:
3279:
3274:
3269:
3264:
3259:
3250:
3249:
3248:
3243:
3238:
3228:
3222:
3217:
3212:
3203:
3198:
3193:
3187:
3182:
3169:
3160:
3154:
3152:
3148:
3147:
3145:
3144:
3139:
3134:
3133:
3132:
3123:
3118:
3113:
3100:
3086:
3081:
3076:
3075:
3074:
3069:
3059:
3053:
3043:
3041:
3032:
3026:
3025:
3022:
3021:
3019:
3018:
3012:
3007:
3002:
2997:
2992:
2983:
2977:
2972:
2963:
2962:
2961:
2956:
2951:
2946:
2936:
2931:
2930:
2929:
2924:
2919:
2914:
2909:
2899:
2893:
2888:
2883:
2878:
2868:
2866:
2862:
2861:
2859:
2858:
2852:
2847:
2842:
2833:
2827:
2822:
2813:
2807:
2802:
2797:
2792:
2775:
2773:
2767:
2766:
2764:
2763:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2698:
2692:
2687:
2682:
2672:
2670:
2664:
2663:
2661:
2660:
2655:
2650:
2645:
2639:
2634:
2625:
2619:
2614:
2604:
2602:
2593:
2583:
2582:
2572:
2565:
2564:
2555:
2553:
2552:
2545:
2538:
2530:
2523:
2522:
2487:
2467:(8): 1416–24.
2452:
2417:
2387:
2352:
2323:
2285:
2250:
2230:(7): 4917–22.
2215:
2170:
2150:(7): 2429–33.
2135:
2100:
2071:
2036:
2007:
1969:(17): 6301–5.
1954:
1925:
1904:
1861:
1823:(13): 5094–8.
1807:
1805:
1802:
1801:
1800:
1779:
1778:External links
1776:
1774:
1773:
1727:
1686:
1635:
1633:
1632:
1630:on 2013-10-24.
1567:
1565:
1564:
1509:
1488:10.1038/nn1945
1462:
1445:
1428:
1410:
1392:
1371:
1349:
1347:
1344:
1343:
1342:
1335:
1332:
1331:
1330:
1325:
1319:
1318:
1314:
1313:
1309:
1308:
1303:
1300:
1292:Laurasiatheria
1259:
1256:
1246:
1234:in either its
1209:repeat element
1205:glutamic acids
1200:
1184:
1180:
1177:
1160:
1156:
1152:
1148:
1144:
1141:
1112:
1103:
1102:
1099:
1098:
1093:
1083:
1082:
1076:
1075:
1072:
1071:
1069:
1067:
1060:
1059:
1052:
1045:
1041:
1040:
1037:
1036:
1026:
1025:
1019:
1016:
1015:
1005:
1004:
998:
994:
993:
990:
989:
979:
978:
972:
969:
968:
958:
957:
951:
947:
946:
943:
942:
934:
933:
927:
924:
923:
915:
914:
908:
902:
901:
898:
897:
889:
888:
882:
879:
878:
870:
869:
863:
857:
856:
853:
852:
844:
843:
837:
834:
833:
825:
824:
818:
812:
811:
806:
801:
797:
796:
786:
785:
782:
781:
770:
769:
767:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
670:
668:
664:
663:
661:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
604:
599:
594:
588:
586:
582:
581:
571:
570:
567:
566:
563:
562:
559:
558:
551:
545:
544:
541:
540:
532:
531:
528:
527:
525:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
481:
480:
469:
466:
465:
463:
462:
461:gastric mucosa
458:
454:
450:
446:
442:
438:
434:
433:left ventricle
430:
426:
422:
419:
418:
406:
405:
397:
386:
380:
379:
376:RNA expression
368:
367:
364:
363:
355:
351:
350:
342:
339:
334:
328:
327:
318:
311:
305:
301:
300:
295:
289:
288:
280:
279:
267:
266:
263:
262:
254:
250:
249:
241:
238:
233:
227:
226:
217:
210:
204:
200:
199:
192:
186:
185:
177:
176:
164:
163:
120:
116:
115:
107:
99:
98:
94:
93:
90:
89:
86:
85:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5472:
5461:
5458:
5456:
5453:
5452:
5450:
5427:
5424:
5423:
5421:
5417:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5361:
5358:
5357:
5355:
5351:
5347:
5343:
5339:
5333:
5329:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5295:
5292:
5289:
5286:
5284:
5281:
5279:
5275:
5272:
5270:
5267:
5264:
5261:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5239:
5236:
5234:
5231:
5229:
5225:
5221:
5218:
5215:
5212:
5210:
5206:
5200:
5198:
5195:
5194:
5192:
5190:
5186:
5179:
5176:
5172:
5169:
5167:
5164:
5162:
5159:
5158:
5157:
5154:
5153:
5151:
5148:
5144:
5140:
5136:
5132:
5129:
5125:
5120:
5116:
5101:
5098:
5096:
5092:
5089:
5087:
5084:
5081:
5078:
5076:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5027:
5024:
5021:
5018:
5016:
5012:
5009:
5007:
5004:
5002:
4999:
4998:
4996:
4994:
4990:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4879:
4876:
4875:
4873:
4871:
4867:
4859:
4856:
4852:
4849:
4847:
4844:
4842:
4839:
4838:
4837:
4834:
4833:
4832:
4829:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4791:
4790:
4787:
4783:
4780:
4776:
4773:
4771:
4768:
4766:
4763:
4762:
4761:
4758:
4757:
4756:
4753:
4747:
4744:
4742:
4739:
4737:
4734:
4733:
4732:
4729:
4728:
4727:
4724:
4718:
4715:
4713:
4710:
4708:
4705:
4704:
4703:
4700:
4699:
4698:
4695:
4694:
4692:
4690:
4686:
4682:
4677:
4673:
4668:
4664:
4645:
4642:
4640:
4637:
4635:
4631:
4628:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4606:
4603:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4561:
4558:
4556:
4553:
4551:
4548:
4547:
4545:
4543:
4539:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4168:
4165:
4164:
4162:
4160:
4156:
4149:
4146:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4018:
4017:
4014:
4013:
4011:
4008:
4004:
4001:
3999:Miscellaneous
3997:
3986:
3983:
3981:
3978:
3976:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3951:
3948:
3946:
3943:
3941:
3937:
3934:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3907:
3904:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3882:
3879:
3877:
3874:
3871:
3868:
3866:
3862:
3859:
3857:
3854:
3851:
3848:
3846:
3842:
3839:
3836:
3832:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3809:
3806:
3804:
3801:
3798:
3795:
3793:
3789:
3786:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3759:
3756:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3683:
3680:
3678:
3674:
3671:
3668:
3665:
3663:
3660:
3658:
3654:
3651:
3649:
3646:
3643:
3640:
3638:
3635:
3633:
3629:
3626:
3622:
3619:
3617:
3614:
3613:
3612:
3609:
3606:
3603:
3601:
3597:
3594:
3592:
3589:
3584:
3581:
3579:
3575:
3572:
3569:
3566:
3564:
3561:
3559:
3556:
3555:
3554:
3551:
3549:
3546:
3543:
3540:
3538:
3534:
3531:
3528:
3525:
3523:
3519:
3517:
3513:
3512:Anaphylatoxin
3510:
3509:
3507:
3503:
3496:
3493:
3491:
3487:
3484:
3481:
3478:
3476:
3472:
3469:
3467:
3463:
3460:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3438:
3435:
3433:
3430:
3427:
3424:
3422:
3418:
3415:
3412:
3409:
3407:
3403:
3400:
3399:
3397:
3395:
3391:
3388:
3384:
3374:
3371:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3344:
3341:
3339:
3336:
3334:
3331:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3289:
3286:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3254:
3251:
3247:
3244:
3242:
3239:
3237:
3234:
3233:
3232:
3229:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3207:
3204:
3202:
3199:
3197:
3194:
3191:
3188:
3186:
3183:
3181:
3177:
3173:
3170:
3168:
3164:
3161:
3159:
3156:
3155:
3153:
3149:
3143:
3140:
3138:
3135:
3131:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3108:
3104:
3101:
3099:
3095:
3092:
3091:
3090:
3089:Prostaglandin
3087:
3085:
3082:
3080:
3077:
3073:
3070:
3068:
3065:
3064:
3063:
3060:
3057:
3054:
3052:
3048:
3045:
3044:
3042:
3040:
3036:
3033:
3027:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2987:
2984:
2981:
2978:
2976:
2973:
2971:
2967:
2964:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2941:
2940:
2937:
2935:
2932:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2904:
2903:
2900:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2873:
2872:Acetylcholine
2870:
2869:
2867:
2863:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2837:
2834:
2831:
2828:
2826:
2823:
2821:
2817:
2814:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2787:
2784:
2782:
2777:
2776:
2774:
2772:
2768:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2702:
2699:
2696:
2693:
2691:
2688:
2686:
2683:
2681:
2677:
2674:
2673:
2671:
2669:
2665:
2659:
2656:
2654:
2651:
2649:
2646:
2643:
2640:
2638:
2635:
2633:
2629:
2626:
2623:
2620:
2618:
2615:
2613:
2609:
2606:
2605:
2603:
2601:
2597:
2594:
2592:
2588:
2584:
2579:
2575:
2570:
2566:
2562:
2558:
2551:
2546:
2544:
2539:
2537:
2532:
2531:
2528:
2519:
2515:
2510:
2505:
2501:
2497:
2493:
2488:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2453:
2449:
2445:
2440:
2435:
2432:(5): 807–15.
2431:
2427:
2423:
2418:
2414:
2410:
2406:
2402:
2399:(3): 469–78.
2398:
2394:
2388:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2353:
2349:
2345:
2341:
2337:
2334:(1): H59–67.
2333:
2329:
2324:
2320:
2316:
2312:
2308:
2304:
2300:
2296:
2292:
2286:
2282:
2278:
2273:
2268:
2264:
2260:
2256:
2251:
2247:
2243:
2238:
2233:
2229:
2225:
2221:
2216:
2212:
2208:
2204:
2200:
2196:
2195:10.1038/46040
2192:
2188:
2184:
2180:
2176:
2171:
2167:
2163:
2158:
2153:
2149:
2145:
2141:
2136:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2101:
2097:
2093:
2089:
2085:
2081:
2077:
2072:
2068:
2064:
2059:
2054:
2050:
2046:
2042:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2012:Life Sciences
2008:
2004:
2000:
1995:
1990:
1985:
1980:
1976:
1972:
1968:
1964:
1960:
1955:
1951:
1947:
1943:
1939:
1936:(2): 817–23.
1935:
1931:
1926:
1922:
1918:
1914:
1910:
1905:
1901:
1897:
1893:
1889:
1884:
1879:
1875:
1871:
1867:
1862:
1858:
1854:
1849:
1844:
1839:
1834:
1830:
1826:
1822:
1818:
1814:
1809:
1808:
1803:
1798:
1794:
1793:
1788:
1787:
1782:
1781:
1777:
1769:
1765:
1760:
1755:
1751:
1747:
1743:
1739:
1731:
1728:
1723:
1719:
1714:
1709:
1705:
1701:
1697:
1690:
1687:
1682:
1678:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1646:
1639:
1636:
1629:
1625:
1621:
1616:
1615:
1612:
1608:
1603:
1598:
1594:
1590:
1586:
1582:
1578:
1571:
1568:
1561:
1557:
1552:
1551:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1513:
1510:
1505:
1501:
1497:
1493:
1489:
1485:
1482:(9): 1137–9.
1481:
1477:
1473:
1466:
1463:
1458:
1452:
1450:
1446:
1441:
1435:
1433:
1429:
1424:
1420:
1414:
1411:
1406:
1402:
1396:
1393:
1389:
1385:
1380:
1378:
1376:
1372:
1368:
1364:
1359:
1357:
1355:
1351:
1345:
1341:
1338:
1337:
1333:
1329:
1326:
1324:
1321:
1320:
1316:
1315:
1311:
1310:
1306:
1305:
1301:
1299:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1265:
1257:
1255:
1253:
1243:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1214:
1210:
1206:
1198:
1194:
1190:
1178:
1176:
1174:
1170:
1167:release from
1166:
1142:
1140:
1138:
1134:
1130:
1126:
1122:
1118:
1110:
1097:
1092:
1088:
1084:
1081:
1077:
1070:
1068:
1065:
1061:
1057:
1053:
1050:
1046:
1042:
1035:
1033:
1027:
1023:
1020:
1014:
1012:
1006:
1002:
999:
995:
988:
986:
980:
976:
973:
967:
965:
959:
955:
952:
950:RefSeq (mRNA)
948:
941:
940:
935:
931:
928:
922:
921:
916:
912:
909:
907:
903:
896:
895:
890:
886:
883:
877:
876:
871:
867:
864:
862:
858:
851:
850:
845:
841:
838:
832:
831:
826:
822:
819:
817:
813:
810:
807:
805:
802:
798:
795:
791:
787:
780:
776:
771:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
671:
669:
666:
665:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
589:
587:
584:
583:
580:
579:Gene ontology
576:
572:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
425:apex of heart
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
5188:
5155:
5128:Metabotropic
4992:
4877:
4830:
4788:
4754:
4725:
4696:
4541:
4166:
4015:
3966:Urotensin-II
3906:Somatostatin
3861:Prokineticin
3758:Melanocortin
3461:
3394:Neuropeptide
3333:Oxoglutarate
3175:
3137:Prostacyclin
3106:
3093:
3046:
2934:GHB receptor
2835:
2778:
2636:
2502:(1): 12–20.
2499:
2495:
2464:
2461:Diabetologia
2460:
2429:
2425:
2396:
2392:
2367:(3): 592–7.
2364:
2361:Hypertension
2360:
2331:
2327:
2297:(3): 203–7.
2294:
2290:
2265:(2): 190–4.
2262:
2258:
2227:
2223:
2178:
2174:
2147:
2143:
2112:
2108:
2079:
2075:
2048:
2044:
2015:
2011:
1966:
1962:
1933:
1929:
1915:(5): 681–8.
1912:
1908:
1876:(2): 430–4.
1873:
1870:FEBS Letters
1869:
1820:
1816:
1791:
1785:
1741:
1737:
1730:
1703:
1699:
1689:
1648:
1644:
1638:
1628:the original
1623:
1584:
1580:
1570:
1559:
1522:
1518:
1512:
1479:
1475:
1465:
1422:
1413:
1404:
1395:
1267:
1263:
1261:
1244:
1182:
1146:
1128:
1108:
1106:
1029:
1008:
982:
961:
937:
918:
892:
873:
847:
828:
808:
803:
658:cell surface
495:human kidney
487:right kidney
453:tibial nerve
399:
392:
358:127,209,141
345:127,205,128
119:External IDs
78:
4836:Latrophilin
3971:Vasopressin
3956:Thyrotropin
3533:Angiotensin
3486:Neurotensin
3163:Cannabinoid
3142:Thromboxane
1759:10072/28568
1581:J. Neurosci
1519:Psychol Sci
1317:Antagonists
1272:nuclear DNA
1197:translation
257:96,116,571
244:96,112,876
97:Identifiers
5449:Categories
5426:Smoothened
5419:Smoothened
5342:Smoothened
5001:Calcitonin
3936:Tachykinin
3833:, but not
3827:Nociceptin
3693:Kisspeptin
3611:Endothelin
3574:Bradykinin
3462:Neuromedin
3039:Eicosanoid
2668:Purinergic
2600:Adrenergic
1390:, May 2017
1369:, May 2017
1346:References
1288:Afrotheria
1252:reboxetine
403:(ortholog)
140:HomoloGene
5336:Class F:
5135:pheromone
5131:glutamate
4555:Olfactory
3591:Chemokine
3373:Succinate
3158:Bile acid
2966:Melatonin
2939:Histamine
2779:(all but
2771:Serotonin
2676:Adenosine
2578:Rhodopsin
2211:205047992
1328:Yohimbine
1284:Xenarthra
1280:placental
1258:Evolution
1133:orthologs
1131:. ADRA2B
1032:NP_033763
1011:NP_000673
985:NM_009633
964:NM_000682
794:Orthologs
148:GeneCards
5360:Frizzled
5353:Frizzled
5338:Frizzled
5180:, type 2
5086:Secretin
5026:Glucagon
4731:Cadherin
4689:Adhesion
4676:Secretin
4009:, bitter
3856:Oxytocin
3553:Bombesin
3201:Estrogen
2902:Dopamine
2518:15592690
2483:15309292
2448:15166301
2413:15037199
2383:14744925
2348:12946937
2319:10913264
2311:12822042
2281:12535806
2246:11056163
2203:10647009
2166:10404816
2131:10224112
1900:24246875
1768:19243956
1722:12446807
1673:11214318
1611:24155306
1539:24058067
1496:17660814
1386:–
1365:–
1334:See also
1323:Imiloxan
1307:Agonists
1143:Receptor
1080:Wikidata
773:Sources:
643:membrane
499:yolk sac
5149:, sweet
5124:Class C
5056:PACAPR1
4672:Class B
3881:Relaxin
3803:Motilin
3688:Ghrelin
3653:Galanin
3386:Peptide
2574:Class A
2183:Bibcode
2096:9435676
2067:9235896
2032:3012234
2003:2842764
1971:Bibcode
1950:2173582
1921:2172775
1892:2169434
1857:2164221
1825:Bibcode
1681:4398233
1653:Bibcode
1602:6618435
1547:9603198
1388:Ensembl
1367:Ensembl
1302:Ligands
1276:mammals
1232:introns
1159:, and α
1137:mammals
906:UniProt
861:Ensembl
800:Species
779:QuickGO
503:decidua
378:pattern
104:Aliases
5340:&
5269:GPRC6A
5006:CALCRL
4870:Orphan
4159:Orphan
4150:type 1
3841:Orexin
3829:&
3808:Opioid
3548:Apelin
2516:
2481:
2446:
2411:
2381:
2346:
2317:
2309:
2279:
2244:
2209:
2201:
2175:Nature
2164:
2129:
2094:
2065:
2030:
2001:
1994:281957
1991:
1948:
1919:
1898:
1890:
1855:
1845:
1792:ADRA2B
1786:ADRA2B
1783:Human
1766:
1720:
1679:
1671:
1645:Nature
1609:
1599:
1545:
1537:
1504:899166
1502:
1494:
1294:, and
1264:ADRA2B
1236:coding
1216:kinase
1189:eIF-2B
1129:ADRA2B
1066:search
1064:PubMed
939:P30545
920:P18089
816:Entrez
549:BioGPS
511:embryo
507:embryo
441:spleen
236:2q11.2
152:ADRA2B
128:104260
111:ADRA2B
33:ADRA2B
18:ADRA2B
5189:Other
5156:TAS1R
5147:Taste
5045:GLP2R
5040:GLP1R
4993:Other
4858:ELTD1
4831:ADGRL
4789:ADGRG
4755:ADGRE
4726:ADGRC
4697:ADGRB
4678:-like
4560:Opsin
4542:Other
4016:TAS2R
4007:Taste
3835:Sigma
3817:Kappa
3812:Delta
3520:C5a (
3505:Other
3151:Other
3079:FPRL1
3047:CysLT
2865:Other
2816:5-HT2
2786:5-HT1
2781:5-HT3
2580:-like
2315:S2CID
2207:S2CID
1896:S2CID
1848:54268
1677:S2CID
1543:S2CID
1500:S2CID
1228:obese
849:11552
809:Mouse
804:Human
775:Amigo
519:liver
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
136:87935
5294:RAIG
5202:GABA
5035:GIPR
4782:CD97
4630:SREB
4431:137B
4406:109B
4401:109A
3831:Zeta
3788:MCHR
3568:NMBR
3563:GRPR
3558:BRS3
3196:EBI2
3062:LTB4
2986:TAAR
2836:5-HT
2514:PMID
2479:PMID
2444:PMID
2409:PMID
2379:PMID
2344:PMID
2307:PMID
2277:PMID
2242:PMID
2199:PMID
2162:PMID
2127:PMID
2092:PMID
2063:PMID
2028:PMID
1999:PMID
1946:PMID
1917:PMID
1888:PMID
1853:PMID
1764:PMID
1718:PMID
1669:PMID
1607:PMID
1535:PMID
1492:PMID
1268:A2AB
1262:The
1191:, a
1125:gene
1107:The
384:Bgee
332:Band
293:Chr.
231:Band
190:Chr.
124:OMIM
81:2CVA
62:RCSB
59:PDBe
5288:179
5283:158
5278:156
5274:GPR
5061:GPR
4982:157
4977:155
4972:144
4967:143
4962:133
4957:128
4952:126
4947:125
4942:124
4937:123
4932:116
4927:115
4922:114
4917:113
4912:112
4907:111
4902:110
4878:GPR
4760:EMR
4599:RRH
4594:RGR
4589:1SW
4584:1MW
4579:1LW
4531:183
4526:182
4521:177
4516:176
4511:174
4506:173
4501:171
4496:162
4491:161
4486:160
4481:153
4476:152
4471:151
4466:150
4461:149
4456:148
4451:146
4446:142
4441:141
4436:139
4426:135
4421:132
4416:120
4411:119
4396:103
4391:101
4167:GPR
3703:MAS
3648:FSH
3516:C3a
3402:B/W
3338:PAF
3190:119
3176:GPR
3172:CB2
3167:CB1
3128:),
3105:),
3084:OXE
2701:P2Y
2690:A2B
2685:A2A
2504:doi
2469:doi
2434:doi
2401:doi
2369:doi
2336:doi
2332:286
2299:doi
2267:doi
2232:doi
2228:276
2191:doi
2179:402
2152:doi
2117:doi
2113:274
2084:doi
2080:273
2053:doi
2049:272
2020:doi
1989:PMC
1979:doi
1938:doi
1934:172
1878:doi
1874:269
1843:PMC
1833:doi
1754:hdl
1746:doi
1708:doi
1661:doi
1649:409
1597:PMC
1589:doi
1527:doi
1484:doi
1238:or
1226:in
1155:, α
830:151
557:n/a
354:End
253:End
156:OMA
144:553
132:MGI
52:PDB
5451::
5409:10
5265:))
5133:/
5126::
5030:GR
4897:98
4892:97
4887:64
4882:56
4674::
4386:92
4381:88
4376:87
4371:85
4366:84
4361:83
4356:82
4351:81
4346:78
4341:75
4336:68
4331:65
4326:63
4321:62
4316:61
4311:55
4306:52
4301:50
4296:45
4291:44
4286:42
4281:39
4276:37
4271:35
4266:34
4261:33
4256:32
4251:31
4246:27
4241:26
4236:25
4231:23
4226:22
4221:21
4216:20
4211:19
4206:18
4201:17
4196:15
4191:12
4141:60
4136:50
4131:46
4126:45
4121:43
4116:42
4111:41
4106:40
4101:39
4096:38
4091:31
4086:30
4081:20
4076:19
4071:16
4066:14
4061:13
4056:10
3980:1B
3975:1A
3822:Mu
3752:X4
3747:X3
3742:X2
3737:X1
3712:1L
3583:B2
3578:B1
3529:))
3482:))
3417:FF
3192:))
3185:55
3180:18
3174:,
3130:FP
3107:EP
3094:DP
2980:1C
2975:1B
2970:1A
2959:H4
2954:H3
2949:H2
2944:H1
2927:D5
2922:D4
2917:D3
2912:D2
2907:D1
2896:M5
2891:M4
2886:M3
2881:M2
2876:M1
2845:5A
2760:14
2755:13
2750:12
2745:11
2740:10
2695:A3
2680:A1
2658:β3
2653:β2
2648:β1
2628:α2
2608:α1
2576::
2559::
2512:.
2500:50
2498:.
2494:.
2477:.
2465:47
2463:.
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2016:38
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1967:85
1965:.
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1478:.
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1448:^
1431:^
1421:.
1403:.
1374:^
1353:^
1290:,
1286:,
1247:2B
1242:.
1201:2B
1185:2B
1175:.
1161:2C
1157:2B
1153:2A
1139:.
1113:2B
1111:(α
777:/
360:bp
347:bp
259:bp
246:bp
154:;
150::
146:;
142::
138:;
134::
130:;
126::
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5404:9
5399:8
5394:7
5389:6
5384:5
5379:4
5374:3
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5243:4
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4851:3
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4809:4
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4775:3
4770:2
4765:1
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4741:2
4736:1
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4644:3
4639:2
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4626:)
4624:4
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4609:1
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4036:5
4031:4
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3920:3
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3667:3
3662:2
3657:1
3655:(
3644:)
3642:3
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3621:B
3616:A
3607:)
3605:B
3600:A
3598:(
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3576:(
3570:)
3544:)
3542:2
3537:1
3535:(
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3466:B
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