228:
1792:
29:
695:
465:
Cid JM, Tresadern G, Duvey G, Lütjens R, Finn T, Rocher JP, et al. (August 2014). "Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor".
699:
760:
753:
1886:
1772:
41:
746:
1837:
1768:
315:
1326:
1185:
942:
651:
Dunlop J, Brandon NJ (February 2015). "Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?".
301:
723:
1891:
1856:
728:
1830:
696:"Addex Reports Top-line Data from ADX71149 Phase 2a Study in Patients with Major Depressive Disorder (MDD) with Significant Anxiety Symptoms"
1871:
1896:
1455:
1056:
1823:
1671:
1572:
1500:
1396:
1247:
1089:
903:
789:
394:
374:
335:
343:
InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3
1387:
1080:
780:
769:
65:
1730:
1634:
1547:
1475:
370:
1861:
1764:
167:
503:"Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor"
410:
207:
937:
398:
552:"Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813"
604:"Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics"
136:
1311:
1163:
386:
947:
813:
196:
1876:
382:
127:
1881:
223:
409:, it was not enough to warrant further development for this indication. As of 2015, ADX-71149 is in
1799:
82:
1316:
1168:
1735:
1725:
1639:
1624:
1552:
1542:
1480:
1470:
1443:
1108:
863:
772:
676:
501:
Lavreysen H, Ahnaou A, Drinkenburg W, Langlois X, Mackie C, Pype S, et al. (February 2015).
426:
1438:
1153:
883:
878:
843:
1745:
1649:
1562:
1490:
1306:
1158:
1009:
893:
668:
633:
581:
532:
483:
156:
1807:
967:
738:
91:
1866:
660:
623:
615:
571:
563:
522:
514:
475:
244:
1791:
848:
176:
1740:
1720:
1644:
1619:
1557:
1537:
1485:
1465:
1356:
1215:
1004:
962:
888:
828:
227:
1803:
628:
603:
576:
551:
550:
Lavreysen H, Langlois X, Donck LV, Nuñez JM, Pype S, Lütjens R, Megens A (March 2015).
527:
502:
406:
1850:
1286:
1133:
957:
873:
823:
414:
390:
116:
680:
1175:
1041:
1036:
733:
1368:
1232:
1066:
1014:
999:
619:
1710:
1450:
1351:
1346:
1301:
1296:
1291:
1210:
1205:
1148:
1143:
1138:
994:
974:
446:
441:
436:
277:
147:
664:
1695:
1609:
1596:
1519:
1428:
1415:
1373:
1281:
1276:
1237:
1128:
1123:
952:
927:
838:
833:
818:
431:
672:
637:
585:
536:
487:
20:
1661:
1361:
1220:
1024:
1019:
853:
1051:
1046:
1031:
868:
402:
102:
479:
28:
1654:
1591:
1271:
1266:
1225:
1118:
1113:
187:
567:
518:
73:
1-Butyl-3-chloro-4-(4-phenylpiperidin-1-yl)-1,2-dihydropyridin-2-one
1700:
1629:
1601:
1524:
1433:
1420:
1341:
1331:
1200:
1190:
989:
932:
300:
291:
393:. It was also researched by these companies for the treatment of
1690:
1336:
1195:
1061:
984:
922:
808:
742:
212:
1672:
1573:
1501:
1397:
1248:
1090:
904:
790:
1811:
405:
symptoms), but although some efficacy was observed in
1670:
1571:
1499:
1395:
1386:
1246:
1088:
1079:
902:
788:
779:
289:
276:
243:
238:
206:
186:
166:
146:
135:
126:
101:
81:
56:
40:
35:
597:
595:
115:
724:ADX71149 for Schizophrenia - Addex Therapeutics
90:
1887:Experimental drugs developed for schizophrenia
1831:
754:
8:
19:
323:CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)C3=CC=CC=C3
1838:
1824:
1392:
1085:
785:
761:
747:
739:
226:
155:
27:
1773:Glutamate metabolism/transport modulators
1680:Tooltip Metabotropic glutamate receptor 8
1581:Tooltip Metabotropic glutamate receptor 7
1509:Tooltip Metabotropic glutamate receptor 6
1405:Tooltip Metabotropic glutamate receptor 4
1256:Tooltip Metabotropic glutamate receptor 3
1098:Tooltip Metabotropic glutamate receptor 2
912:Tooltip Metabotropic glutamate receptor 5
798:Tooltip Metabotropic glutamate receptor 1
729:ADX71149 for Anxiety - Addex Therapeutics
627:
575:
526:
175:
1769:Ionotropic glutamate receptor modulators
556:Pharmacology Research & Perspectives
507:Pharmacology Research & Perspectives
457:
340:
320:
222:
70:
694:Addex Therapeutics (7 February 2014).
18:
195:
7:
1788:
1786:
602:Walker AG, Conn PJ (February 2015).
1312:Pomaglumetad methionil (LY-2140023)
1164:Pomaglumetad methionil (LY-2140023)
106:
1810:. You can help Knowledge (XXG) by
14:
1790:
264:
261:
255:
1708:Positive allosteric modulators:
1659:Negative allosteric modulators:
1448:Positive allosteric modulators:
1366:Negative allosteric modulators:
1230:Negative allosteric modulators:
1173:Positive allosteric modulators:
1029:Negative allosteric modulators:
972:Positive allosteric modulators:
770:Metabotropic glutamate receptor
608:Current Opinion in Pharmacology
348:Key:HYOGJHCDLQSAHX-UHFFFAOYSA-N
1892:Positive allosteric modulators
1857:Drugs not assigned an ATC code
468:Journal of Medicinal Chemistry
270:
249:
1:
1765:Receptor/signaling modulators
653:Journal of Psychopharmacology
371:positive allosteric modulator
1913:
1872:MGlu5 receptor antagonists
1785:
620:10.1016/j.coph.2014.11.003
239:Chemical and physical data
1897:Nervous system drug stubs
1758:
1297:LY-404,039 (pomaglumetad)
1144:LY-404,039 (pomaglumetad)
399:major depressive disorder
381:. It is being studied by
331:
311:
61:
26:
1802:article relating to the
1176:JNJ-40411813 (ADX-71149)
665:10.1177/0269881114565806
734:ADX 71149 - AdisInsight
387:Janssen Pharmaceuticals
389:for the treatment of
413:clinical trials for
1862:4-Phenylpiperidines
23:
427:Biphenylindanone A
395:anxious depression
383:Addex Therapeutics
1819:
1818:
1780:
1779:
1754:
1753:
1703:
1604:
1527:
1423:
1382:
1381:
1075:
1074:
480:10.1021/jm500496m
369:, is a selective
356:
355:
302:Interactive image
208:CompTox Dashboard
16:Chemical compound
1904:
1840:
1833:
1826:
1794:
1787:
1701:
1681:
1677:
1602:
1582:
1578:
1525:
1510:
1506:
1421:
1406:
1402:
1393:
1257:
1253:
1099:
1095:
1086:
913:
909:
799:
795:
786:
763:
756:
749:
740:
712:
711:
709:
707:
698:. Archived from
691:
685:
684:
648:
642:
641:
631:
599:
590:
589:
579:
547:
541:
540:
530:
498:
492:
491:
474:(15): 6495–512.
462:
361:, also known as
304:
284:
272:
266:
263:
257:
251:
231:
230:
216:
214:
199:
179:
159:
139:
119:
109:
108:
94:
31:
24:
22:
1912:
1911:
1907:
1906:
1905:
1903:
1902:
1901:
1847:
1846:
1845:
1844:
1783:
1781:
1776:
1750:
1679:
1676:
1666:
1580:
1577:
1567:
1508:
1505:
1495:
1404:
1401:
1378:
1255:
1252:
1242:
1097:
1094:
1071:
963:Quisqualic acid
911:
908:
898:
829:Quisqualic acid
797:
794:
775:
767:
720:
715:
705:
703:
693:
692:
688:
650:
649:
645:
601:
600:
593:
568:10.1002/prp2.97
549:
548:
544:
519:10.1002/prp2.96
500:
499:
495:
464:
463:
459:
455:
423:
407:clinical trials
378:
352:
349:
344:
339:
338:
327:
324:
319:
318:
307:
282:
269:
260:
254:
234:
224:DTXSID401150484
210:
202:
182:
162:
142:
122:
105:
97:
77:
74:
69:
68:
52:
17:
12:
11:
5:
1910:
1908:
1900:
1899:
1894:
1889:
1884:
1879:
1874:
1869:
1864:
1859:
1849:
1848:
1843:
1842:
1835:
1828:
1820:
1817:
1816:
1804:nervous system
1795:
1778:
1777:
1759:
1756:
1755:
1752:
1751:
1749:
1748:
1743:
1738:
1733:
1728:
1723:
1714:
1713:
1698:
1693:
1684:
1682:
1674:
1668:
1667:
1665:
1664:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1613:
1612:
1607:
1599:
1594:
1585:
1583:
1575:
1569:
1568:
1566:
1565:
1560:
1555:
1550:
1545:
1540:
1531:
1530:
1522:
1513:
1511:
1503:
1497:
1496:
1494:
1493:
1488:
1483:
1478:
1473:
1468:
1459:
1458:
1453:
1441:
1436:
1431:
1426:
1418:
1409:
1407:
1399:
1390:
1384:
1383:
1380:
1379:
1377:
1376:
1371:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1320:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1260:
1258:
1250:
1244:
1243:
1241:
1240:
1235:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1179:
1178:
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1102:
1100:
1092:
1083:
1077:
1076:
1073:
1072:
1070:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
978:
977:
965:
960:
955:
950:
945:
940:
935:
930:
925:
916:
914:
906:
900:
899:
897:
896:
891:
886:
881:
876:
871:
866:
857:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
802:
800:
792:
783:
777:
776:
768:
766:
765:
758:
751:
743:
737:
736:
731:
726:
719:
718:External links
716:
714:
713:
702:on 25 May 2015
686:
643:
591:
542:
493:
456:
454:
451:
450:
449:
444:
439:
434:
429:
422:
419:
376:
367:JNJ-mGluR2-PAM
354:
353:
351:
350:
347:
345:
342:
334:
333:
332:
329:
328:
326:
325:
322:
314:
313:
312:
309:
308:
306:
305:
297:
295:
287:
286:
280:
274:
273:
267:
258:
252:
247:
241:
240:
236:
235:
233:
232:
219:
217:
204:
203:
201:
200:
192:
190:
184:
183:
181:
180:
172:
170:
164:
163:
161:
160:
152:
150:
144:
143:
141:
140:
132:
130:
124:
123:
121:
120:
112:
110:
99:
98:
96:
95:
87:
85:
79:
78:
76:
75:
72:
64:
63:
62:
59:
58:
54:
53:
51:
50:
46:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1909:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1855:
1854:
1852:
1841:
1836:
1834:
1829:
1827:
1822:
1821:
1815:
1813:
1809:
1805:
1801:
1796:
1793:
1789:
1784:
1775:
1774:
1770:
1766:
1763:
1757:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1716:
1715:
1712:
1709:
1705:
1699:
1697:
1694:
1692:
1689:
1686:
1685:
1683:
1678:
1669:
1663:
1660:
1656:
1653:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1615:
1614:
1611:
1608:
1606:
1600:
1598:
1595:
1593:
1590:
1587:
1586:
1584:
1579:
1570:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1533:
1532:
1529:
1523:
1521:
1518:
1515:
1514:
1512:
1507:
1498:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1461:
1460:
1457:
1454:
1452:
1449:
1445:
1442:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1419:
1417:
1414:
1411:
1410:
1408:
1403:
1394:
1391:
1389:
1385:
1375:
1372:
1370:
1367:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1343:
1340:
1338:
1335:
1333:
1330:
1328:
1325:
1322:
1321:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1288:
1287:Ibotenic acid
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1262:
1261:
1259:
1254:
1245:
1239:
1236:
1234:
1231:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1181:
1180:
1177:
1174:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1147:
1145:
1142:
1140:
1137:
1135:
1134:Ibotenic acid
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1104:
1103:
1101:
1096:
1087:
1084:
1082:
1078:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
980:
979:
976:
973:
969:
966:
964:
961:
959:
958:Ibotenic acid
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
918:
917:
915:
910:
901:
895:
892:
890:
887:
885:
882:
880:
877:
875:
874:Cyclothiazide
872:
870:
867:
865:
862:
859:
858:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
824:Ibotenic acid
822:
820:
817:
815:
812:
810:
807:
804:
803:
801:
796:
787:
784:
782:
778:
774:
771:
764:
759:
757:
752:
750:
745:
744:
741:
735:
732:
730:
727:
725:
722:
721:
717:
701:
697:
690:
687:
682:
678:
674:
670:
666:
662:
658:
654:
647:
644:
639:
635:
630:
625:
621:
617:
613:
609:
605:
598:
596:
592:
587:
583:
578:
573:
569:
565:
562:(2): e00097.
561:
557:
553:
546:
543:
538:
534:
529:
524:
520:
516:
513:(1): e00096.
512:
508:
504:
497:
494:
489:
485:
481:
477:
473:
469:
461:
458:
452:
448:
445:
443:
440:
438:
435:
433:
430:
428:
425:
424:
420:
418:
416:
415:schizophrenia
412:
408:
404:
400:
396:
392:
391:schizophrenia
388:
384:
380:
372:
368:
364:
360:
346:
341:
337:
330:
321:
317:
310:
303:
299:
298:
296:
293:
288:
281:
279:
275:
248:
246:
242:
237:
229:
225:
221:
220:
218:
209:
205:
198:
197:ChEMBL3337527
194:
193:
191:
189:
185:
178:
174:
173:
171:
169:
165:
158:
154:
153:
151:
149:
145:
138:
134:
133:
131:
129:
125:
118:
114:
113:
111:
104:
100:
93:
89:
88:
86:
84:
80:
71:
67:
60:
55:
48:
47:
45:
43:
39:
36:Clinical data
34:
30:
25:
1877:Chloroarenes
1812:expanding it
1797:
1782:
1761:
1760:
1718:Antagonists:
1717:
1707:
1687:
1658:
1617:Antagonists:
1616:
1588:
1535:Antagonists:
1534:
1516:
1463:Antagonists:
1462:
1447:
1412:
1365:
1324:Antagonists:
1323:
1317:Talaglumetad
1263:
1229:
1183:Antagonists:
1182:
1172:
1169:Talaglumetad
1105:
1042:Dipraglurant
1037:Basimglurant
1028:
982:Antagonists:
981:
971:
919:
861:Antagonists:
860:
805:
704:. Retrieved
700:the original
689:
659:(2): 230–8.
656:
652:
646:
611:
607:
559:
555:
545:
510:
506:
496:
471:
467:
460:
366:
363:JNJ-40411813
362:
358:
357:
92:1127498-03-6
1882:2-Pyridones
1444:VU-0155,041
1369:Decoglurant
1233:Decoglurant
1067:Raseglurant
1015:Remeglurant
1000:Mavoglurant
864:BAY 36-7620
285: g·mol
57:Identifiers
1851:Categories
1711:AZ12216052
1451:Foliglurax
1439:VU-001,171
1352:LY-341,495
1347:LY-307,452
1302:LY-487,379
1292:LY-379,268
1211:LY-341,495
1206:LY-307,452
1154:LY-566,332
1149:LY-487,379
1139:LY-379,268
995:LY-344,545
975:LSN2463359
884:LY-456,236
879:LY-367,385
773:modulators
453:References
447:LY-487,379
442:LY-379,268
437:LY-404,039
290:3D model (
278:Molar mass
177:612BYT76F3
148:ChemSpider
128:IUPHAR/BPS
83:CAS Number
66:IUPAC name
1762:See also:
1696:Glutamate
1688:Agonists:
1610:LSP2-9166
1597:Glutamate
1589:Agonists:
1520:Glutamate
1517:Agonists:
1429:LSP2-9166
1416:Glutamate
1413:Agonists:
1388:Group III
1374:RO4491533
1282:Glutamate
1277:Eglumegad
1264:Agonists:
1238:RO4491533
1129:Glutamate
1124:Eglumegad
1106:Agonists:
953:Glutamate
928:ADX-47273
920:Agonists:
844:Ro67-7476
839:Ro67-4853
834:Ro01-6128
819:Glutamate
806:Agonists:
432:Eglumegad
359:ADX-71149
21:ADX-71149
1746:UBP-1112
1662:ADX71743
1650:UBP-1112
1563:UBP-1112
1491:UBP-1112
1362:MGS-0039
1307:MGS-0028
1221:MGS-0039
1159:MGS-0028
1081:Group II
1025:SIB-1893
1020:SIB-1757
1010:NPS-2390
894:NPS-2390
854:Theanine
681:42542103
673:25586401
638:25462291
614:: 40–5.
586:25692027
537:25692015
488:25032784
421:See also
411:phase II
379:receptor
157:28424210
117:25195461
42:ATC code
1867:Lactams
1052:GRN-529
1047:Fenobam
1032:AZD9272
968:VU-1545
869:CPCCOEt
781:Group I
629:4318747
577:4324682
528:4317228
403:anxiety
373:of the
245:Formula
103:PubChem
1655:XAP044
1592:AMN082
1272:DCG-IV
1267:CBiPES
1226:PCCG-4
1119:DCG-IV
1114:CBiPES
706:24 May
679:
671:
636:
626:
584:
574:
535:
525:
486:
316:SMILES
283:344.88
188:ChEMBL
1806:is a
1798:This
1673:mGluR
1630:MMPIP
1574:mGluR
1502:mGluR
1434:PHCCC
1398:mGluR
1342:HYDIA
1332:CECXG
1327:APICA
1249:mGluR
1201:HYDIA
1191:CECXG
1186:APICA
1091:mGluR
990:DMeOB
933:CDPPB
905:mGluR
849:VU-71
791:mGluR
677:S2CID
401:with
336:InChI
292:JSmol
1808:stub
1800:drug
1741:MTPG
1736:MSOP
1731:MPPG
1726:MAP4
1721:CPPG
1704:-AP4
1691:DCPG
1645:MTPG
1640:MSOP
1635:MPPG
1625:MAP4
1620:CPPG
1605:-AP4
1558:MTPG
1553:MSOP
1548:MPPG
1543:MAP4
1538:CPPG
1528:-AP4
1486:MTPG
1481:MSOP
1476:MPPG
1471:MAP4
1466:CPPG
1456:MPEP
1424:-AP4
1357:MCPG
1337:EGLU
1216:MCPG
1196:EGLU
1109:BINA
1062:MTEP
1057:MPEP
1005:MCPG
985:CTEP
948:DHPG
938:CHPG
923:ACPD
889:MCPG
814:DHPG
809:ACPD
708:2015
669:PMID
634:PMID
582:PMID
533:PMID
484:PMID
385:and
375:mGlu
365:and
168:UNII
137:8946
49:None
943:DFB
661:doi
624:PMC
616:doi
572:PMC
564:doi
523:PMC
515:doi
476:doi
213:EPA
107:CID
1853::
1771:•
1767:•
1706:;
1657:;
1446:;
1364:;
1228:;
1171:;
1027:;
970:;
675:.
667:.
657:29
655:.
632:.
622:.
612:20
610:.
606:.
594:^
580:.
570:.
558:.
554:.
531:.
521:.
509:.
505:.
482:.
472:57
470:.
417:.
262:Cl
259:25
253:20
1839:e
1832:t
1825:v
1814:.
1702:L
1675:8
1603:L
1576:7
1526:L
1504:6
1422:L
1400:4
1251:3
1093:2
907:5
793:1
762:e
755:t
748:v
710:.
683:.
663::
640:.
618::
588:.
566::
560:3
539:.
517::
511:3
490:.
478::
397:(
377:2
294:)
271:O
268:2
265:N
256:H
250:C
215:)
211:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
