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channels from the extracellular membrane side. From the pore blocking mechanism, the pore mutations that change toxic affinity were identified. As a result, the four mutants decreased toxic affinity and several mutants increased it. Therefore, this was consistent with the scanned TM5-TM6 linker
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InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34)
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InChI=1/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34)
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484:) were screened with a venom library for activity against these channels. In result, the robust inhibitory activity was found in the venom. Venom fractionation using
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Herold EE, Yaksh TL (September 1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat".
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664:"Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data"
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Kitaguchi T, Swartz KJ (November 2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom".
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region being the outer vestibule of the channels and further confirming that AG489 is a pore blocker.
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Winter Z, Buhala A, Ötvös F, Jósvay K, Vizler C, Dombi G, et al. (June 2013).
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allowed the purification of two acylpolyamine toxins, AG489 and AG505.
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615:"Transient receptor potential (TRP) channels: a clinical perspective"
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Except where otherwise noted, data are given for materials in their
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To identify new inhibitors, capsaicin receptor channels (TRPV
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44:-(20-Amino-4-hydroxy-4,8,12,17-tetraazaicosan-1-yl)-2-(9
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403:, a North American funnel web spider. It inhibits the
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448:. There might be a discussion about this on
281:O=C(NCCCN(O)CCCNCCCNCCCCNCCCN)Cc2c1ccccc1c2
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719:at the U.S. National Library of Medicine
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250:Key: LIURIBSBVUMOJS-UHFFFAOYSA-N
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413:through a pore blocking mechanism.
260:Key: LIURIBSBVUMOJS-UHFFFAOYAP
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500:Chemical structure of agatoxin 505
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613:Kaneko Y, Szallasi A (May 2014).
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348:(at 25 °C , 100 kPa).
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405:ligand gated ion channel
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48:-purin-3-yl)acetamide
438:confusing or unclear
37:Preferred IUPAC name
446:clarify the section
338: g·mol
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400:Agelenopsis aperta
375:Infobox references
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631:10.1111/bph.12414
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444:Please help
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397:produced by
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63:Identifiers
57:Agatoxin 489
55:Other names
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290:Properties
80:128549-96-2
752:Polyamines
731:Categories
527:References
440:to readers
331:Molar mass
191:4Q64GNZ7KX
136:IUPHAR/BPS
115:ChemSpider
91:3D model (
70:CAS Number
458:July 2024
417:Discovery
700:23800232
649:24102319
600:16300403
521:Agatoxin
515:See also
742:Indoles
691:3707783
640:4008995
562:1519789
436:may be
368:what is
366: (
336:489.709
158:PubChem
17:AG 489
723:(MeSH)
717:AG+489
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674:: 30.
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387:AG 489
363:verify
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274:SMILES
171:131007
124:115840
31:Names
395:venom
239:InChI
93:JSmol
696:PMID
645:PMID
596:PMID
558:PMID
489:HPLC
408:TRPV
389:(or
182:UNII
146:2484
686:PMC
676:doi
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208:EPA
161:CID
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42:N
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