1334:
321:
298:
195:
220:
3527:
586:
579:
572:
327:
226:
40:
1325:
have worse outcome with tamoxifen therapy than all other patients combined. In addition, dormant tumor cells of luminal breast cancers treated with endocrine therapy may acquire with time, mutations that alter kinase signalling pathways and ultimately enhance AIB1 oncogenic functions. Also, estrogen
1305:
kinase pathways result, in one hand in an enhanced AIB1 transcriptional coactivation capacity, and in the other hand in the inhibition of the proteasome-dependent AIB1 turn-over and therefore, in AIB1 overexpression. In both conditions, the equilibrium of estrogen receptor (ER) complex formation is
66:
2790:
Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer".
3048:
Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG (1998). "Transcription factor-specific requirements for coactivators and their acetyltransferase functions".
3254:
Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation".
3526:
2847:
Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (1997). "cDNAs with long CAG trinucleotide repeats from human brain".
3567:
2710:
Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J (2003). "Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1".
2199:"A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA"
334:
233:
1415:
1680:
2050:"Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells"
3892:
2287:
Wong CW, Komm B, Cheskis BJ (June 2001). "Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands".
1294:
2646:
Lee WY, Noy N (February 2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain".
914:
895:
156:
3560:
3928:
2197:
Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001).
3918:
3506:
1502:
1315:
1484:
2972:"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300"
2599:"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300"
2149:
Naltner A, Wert S, Whitsett JA, Yan C (December 2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung".
3923:
3553:
3015:"TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1"
1641:"TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1"
1561:"TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1"
320:
3086:
Shirazi SK, Bober MA, Coetzee GA (1998). "Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene)".
1147:
1140:
1306:
displaced towards a transcriptionally active complex and thus, counteracting the inhibition caused by anti-estrogenic drugs such as
127:, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, nuclear receptor coactivator 3
297:
1318:). The result is the restoration of estrogen-sensitive gene transcription and the promotion of cancer progression and/or relapse.
2693:
3871:
3866:
2424:"BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation"
1471:
1450:
1333:
1520:
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (August 1997).
3714:
3704:
219:
194:
2473:"Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140"
1467:
63:
2514:"Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators"
1446:
2562:
136:
2937:
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997).
1688:
1600:
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997).
3620:
1347:
1282:
1250:
activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates
2749:"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs"
333:
232:
326:
225:
3576:
3499:
1421:
1247:
2687:
1862:"Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer"
959:
144:
2597:
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (August 1997).
3846:
3213:"Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase"
1397:
1385:
1330:
expression may result in de novo HER2/neu expression and initiate endocrine therapy resistance and relapse.
1275:
940:
3285:"Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2"
2324:"Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells"
3831:
3652:
3584:
2683:
1817:"Phosphoinositide 3-kinase/AKT signaling can promote AIB1 stability independently of GSK3 phosphorylation"
1391:
1239:
1901:
Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, et al. (December 2008).
1709:
Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, et al. (December 2008).
1302:
208:
2970:
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (1997).
3628:
3492:
3331:
3058:
2897:
2335:
1914:
1722:
1367:
123:
3170:"Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1"
1096:
1092:
1066:
1037:
1033:
3535:: Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR
3242:
3111:
3001:
2872:
2735:
2696:
2628:
2579:
2571:
2266:
2258:
2174:
168:
1104:
1100:
1062:
1041:
1029:
3472:
3437:
3394:
3359:
3306:
3271:
3234:
3199:
3156:
3103:
3074:
3036:
2993:
2958:
2925:
2864:
2835:
2800:
2778:
2727:
2663:
2620:
2554:
2535:
2494:
2453:
2404:
2363:
2304:
2247:
2228:
2166:
2131:
2071:
2030:
1981:
1940:
1883:
1838:
1797:
1748:
1662:
1621:
1582:
1541:
1355:
585:
578:
571:
116:
56:
3373:"Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3"
2383:"Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3"
2322:
Tikkanen MK, Carter DJ, Harris AM, Le HM, Azorsa DO, Meltzer PS, Murdoch FE (November 2000).
2102:"Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase"
3462:
3427:
3419:
3384:
3349:
3339:
3296:
3263:
3224:
3189:
3181:
3146:
3136:
3095:
3066:
3026:
2983:
2950:
2915:
2905:
2856:
2825:
2768:
2760:
2719:
2655:
2610:
2546:
2525:
2484:
2443:
2435:
2394:
2353:
2343:
2296:
2239:
2218:
2210:
2158:
2121:
2113:
2061:
2020:
2012:
1971:
1930:
1922:
1873:
1857:
1828:
1787:
1779:
1738:
1730:
1652:
1613:
1572:
1533:
1298:
1255:
1243:
413:
344:
288:
243:
2886:"RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2"
164:
388:
3408:"AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor"
3335:
3062:
2901:
2339:
1918:
1768:"AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor"
1726:
3151:
3124:
3099:
2025:
2000:
1935:
1902:
1743:
1710:
39:
3229:
3212:
3194:
3169:
2988:
2971:
2773:
2748:
2723:
2615:
2598:
2448:
2423:
2223:
2198:
2126:
2101:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
738:
733:
728:
723:
718:
713:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
3912:
3432:
3423:
3407:
3354:
3319:
2920:
2885:
2439:
2358:
2323:
2162:
2117:
2097:
1792:
1783:
1767:
1254:, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists
614:
3246:
3005:
2876:
2739:
2632:
2178:
148:
3115:
406:
185:
3451:"Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator"
1960:"Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator"
1833:
1816:
3070:
2954:
2471:
Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (April 2001).
2001:"Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer"
1903:"Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen"
1711:"Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen"
1617:
1537:
172:
3779:
1507:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1489:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1311:
2512:
Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (October 2000).
489:
3662:
3320:"CBP/p300 interact with and function as transcriptional coactivators of BRCA1"
2214:
305:
202:
152:
3545:
3141:
3031:
3014:
2939:"AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer"
1999:
Gnanapragasam VJ, Leung HY, Pulimood AS, Neal DE, Robson CN (December 2001).
1657:
1640:
1602:"AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer"
1577:
1560:
1522:"AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer"
3801:
3467:
3450:
3301:
3284:
3267:
2910:
2814:"Normalization and subtraction: two approaches to facilitate gene discovery"
2550:
2243:
1976:
1959:
1878:
1861:
1307:
1271:
859:
549:
427:
372:
359:
271:
258:
160:
3476:
3441:
3398:
3389:
3372:
3363:
3344:
3310:
3275:
3238:
3185:
3125:"SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4"
2731:
2667:
2558:
2539:
2530:
2513:
2498:
2489:
2472:
2457:
2408:
2399:
2382:
2367:
2348:
2308:
2251:
2232:
2170:
2135:
2075:
2066:
2049:
2034:
2016:
1985:
1944:
1887:
1842:
1801:
1752:
1293:(PI3K), activating mutations in the proto-oncogene tyrosine-protein kinase
1285:
resistance (depicted in the figure). Signaling pathways or mutations (i.e.
3203:
3160:
3107:
3078:
3040:
2997:
2962:
2929:
2868:
2860:
2839:
2804:
2782:
2764:
2624:
2568:. If this is an intentional citation to a retracted paper, please replace
2255:. If this is an intentional citation to a retracted paper, please replace
1666:
1625:
1586:
1545:
1187:
1182:
3694:
3690:
1322:
1286:
1171:
1004:
985:
3283:
Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (2000).
2659:
2048:
Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (April 2004).
1926:
1734:
3897:
3700:
3600:
2830:
2813:
1251:
1208:
971:
926:
2300:
1559:
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (October 1997).
1321:
Notably, tumors diagnosed with concomitant overexpression of AIB1 and
1270:
to AIB-1 protein expression may be predictive of the effectiveness of
93:
89:
85:
3861:
3857:
3853:
3821:
1290:
1155:
881:
698:
DNA-binding transcription factor activity, RNA polymerase II-specific
17:
2938:
2422:
Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (September 2003).
1601:
1521:
1815:
Ferrero M, Avivar A, García-Macías MC, Font de Mora J (July 2008).
3841:
3836:
3826:
3811:
3795:
3791:
3764:
3754:
3744:
3734:
3680:
3676:
3646:
3642:
3638:
3624:
3615:
3610:
3604:
3596:
3168:
Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (1999).
1403:
1373:
1332:
1326:
receptor-PAX2 complexes repress HER2/neu expression, but loss of
844:
840:
3806:
3667:
3656:
1409:
1379:
1361:
1327:
1267:
1215:
140:
3549:
3488:
594:
3484:
3013:
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997).
1639:
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997).
1337:
Mechanisms for AIB1-dependent anti-estrogen therapy resistance
3318:
Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM (2000).
1281:
Several molecular mechanisms implicate NCOA3 (AIB1) in the
1218:. NCOA3 is also frequently called 'amplified in breast 1' (
795:
positive regulation of transcription by RNA polymerase II
1958:
Tan JA, Hall SH, Petrusz P, French FS (September 2000).
396:
825:
positive regulation of stem cell population maintenance
1226:), or thyroid hormone receptor activator molecule 1 (
561:
3885:
3778:
3583:
3211:Chen H, Lin RJ, Xie W, Wilpitz D, Evans RM (1999).
1118:
1085:
1055:
1022:
785:
positive regulation of transcription, DNA-templated
770:
positive regulation of keratinocyte differentiation
2096:Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY,
1463:
1461:
1459:
1442:
1440:
1438:
1346:Nuclear receptor coactivator 3 has been shown to
343:
242:
1416:Peroxisome proliferator-activated receptor gamma
2282:
2280:
2192:
2190:
2188:
2091:
2089:
2087:
2085:
1681:"Study sheds new light on tamoxifen resistance"
3449:Tan JA, Hall SH, Petrusz P, French FS (2000).
2747:Liu F, Ventura F, Doody J, Massagué J (1995).
1468:GRCm38: Ensembl release 89: ENSMUSG00000027678
1297:, etc.) that lead to persistent activation of
3561:
3500:
8:
3893:Chromatin Structure Remodeling (RSC) Complex
1856:Osborne CK, Bardou V, Hopp TA, Chamness GC,
1447:GRCh38: Ensembl release 89: ENSG00000124151
3568:
3554:
3546:
3507:
3493:
3485:
2582:|...|intentional=yes}}
2269:|...|intentional=yes}}
855:
765:regulation of transcription, DNA-templated
610:
384:
283:
180:
74:
3466:
3431:
3388:
3353:
3343:
3300:
3228:
3193:
3150:
3140:
3123:Wang JC, Stafford JM, Granner DK (1998).
3030:
2987:
2919:
2909:
2829:
2772:
2686:at the U.S. National Library of Medicine
2614:
2529:
2488:
2447:
2398:
2357:
2347:
2222:
2125:
2065:
2024:
1975:
1934:
1877:
1832:
1791:
1742:
1656:
1576:
2812:Bonaldo MF, Lennon G, Soares MB (1997).
1866:Journal of the National Cancer Institute
1289:overexpression, activating mutations in
1258:in the upregulation of gene expression.
805:intracellular receptor signaling pathway
3522:
1434:
775:cellular response to estradiol stimulus
2381:Leo C, Li H, Chen JD (February 2000).
2151:Am. J. Physiol. Lung Cell Mol. Physiol
1860:, Fuqua SA, et al. (March 2003).
1316:selective estrogen receptor modulators
790:positive regulation of gene expression
760:regulation of RNA biosynthetic process
29:
1766:Font de Mora J, Brown M (July 2000).
1246:interacting domains and an intrinsic
815:cellular response to hormone stimulus
673:nuclear receptor coactivator activity
348:
309:
304:
247:
206:
201:
7:
1687:. Cordis. 2008-11-13. Archived from
1222:), steroid receptor coactivator-3 (
1211:that, in humans, is encoded by the
755:androgen receptor signaling pathway
683:protein heterodimerization activity
3100:10.1111/j.1399-0004.1998.tb03704.x
1115:
1082:
1052:
1019:
995:
976:
950:
931:
905:
886:
688:disordered domain specific binding
653:histone acetyltransferase activity
643:transcription coactivator activity
566:
484:
422:
401:
25:
693:RNA polymerase II complex binding
3886:ATP-dependent remodeling factors
3525:
3424:10.1128/MCB.20.14.5041-5047.2000
3406:Font de Mora J, Brown M (2000).
2884:Li H, Gomes PJ, Chen JD (1997).
2440:10.1128/MCB.23.17.6210-6220.2003
2163:10.1152/ajplung.2000.279.6.l1066
2118:10.1128/MCB.22.10.3549-3561.2002
1784:10.1128/MCB.20.14.5041-5047.2000
830:regulation of stem cell division
648:thyroid hormone receptor binding
584:
577:
570:
332:
325:
319:
296:
231:
224:
218:
193:
38:
3929:PAS-domain-containing proteins
2684:nuclear receptor coactivator 3
1772:Molecular and Cellular Biology
1242:protein that contains several
1201:nuclear receptor coactivator 3
595:More reference expression data
550:More reference expression data
1:
3371:Leo C, Li H, Chen JD (2000).
3230:10.1016/S0092-8674(00)80054-9
2989:10.1016/S0092-8674(00)80516-4
2724:10.1016/S0960-0760(02)00254-6
2712:J. Steroid Biochem. Mol. Biol
2616:10.1016/S0092-8674(00)80516-4
1834:10.1158/0008-5472.CAN-07-6433
633:protein dimerization activity
317:
216:
3919:Genes on human chromosome 20
3324:Proc. Natl. Acad. Sci. U.S.A
3071:10.1126/science.279.5351.703
2955:10.1126/science.277.5328.965
2890:Proc. Natl. Acad. Sci. U.S.A
2328:Proc. Natl. Acad. Sci. U.S.A
1618:10.1126/science.277.5328.965
1538:10.1126/science.277.5328.965
780:transcription, DNA-templated
1238:NCOA3 is a transcriptional
458:superficial temporal artery
3945:
3924:Transcription coregulators
3577:Transcription coregulators
2100:, O'Malley BW (May 2002).
739:protein-containing complex
638:protein N-terminus binding
3520:
1503:"Mouse PubMed Reference:"
1485:"Human PubMed Reference:"
1422:Retinoid X receptor alpha
1248:histone acetyltransferase
1186:
1181:
1177:
1170:
1154:
1148:Chr 2: 165.99 – 166.07 Mb
1135:
1122:
1089:
1078:
1059:
1026:
1015:
1002:
998:
983:
979:
970:
957:
953:
938:
934:
925:
912:
908:
893:
889:
880:
865:
858:
854:
838:
663:androgen receptor binding
613:
609:
592:
569:
560:
547:
496:
487:
446:epithelium of nasopharynx
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
82:
77:
60:
55:
50:
46:
37:
32:
3142:10.1074/jbc.273.47.30847
3032:10.1074/jbc.272.44.27629
2688:Medical Subject Headings
1658:10.1074/jbc.272.44.27629
1578:10.1074/jbc.272.44.27629
800:receptor transactivation
678:acyltransferase activity
668:nuclear receptor binding
442:tendon of biceps brachii
3847:Tripartite motif family
3468:10.1210/endo.141.9.7680
3302:10.1210/mend.13.12.0381
3268:10.1242/jcs.112.20.3519
2911:10.1073/pnas.94.16.8479
2551:10.1074/jbc.A113.000517
2244:10.15252/embj.201470090
2215:10.1093/emboj/20.6.1341
1977:10.1210/endo.141.9.7680
1398:Glucocorticoid receptor
1386:Estrogen receptor alpha
1276:breast cancer treatment
1141:Chr 20: 47.5 – 47.66 Mb
27:Protein found in humans
3390:10.1074/jbc.275.8.5976
3345:10.1073/pnas.97.3.1020
3186:10.1101/gad.12.22.3488
2531:10.1074/jbc.C000517200
2490:10.1210/mend.15.4.0624
2400:10.1074/jbc.275.8.5976
2349:10.1073/pnas.220427297
2067:10.1074/jbc.M400970200
2017:10.1054/bjoc.2001.2179
1392:Estrogen receptor beta
1338:
820:cell dedifferentiation
2861:10.1007/s004390050476
2765:10.1128/mcb.15.7.3479
2574:|...}}
2545:(Retracted, see
2261:|...}}
2238:(Retracted, see
1879:10.1093/jnci/95.5.353
1336:
1262:Clinical significance
724:extracellular exosome
470:palpebral conjunctiva
209:Chromosome 20 (human)
1368:CREB-binding protein
628:transferase activity
311:Chromosome 2 (mouse)
78:List of PDB id codes
51:Available structures
3336:2000PNAS...97.1020P
3063:1998Sci...279..703K
2902:1997PNAS...94.8479L
2340:2000PNAS...9712536T
1927:10.1038/nature07483
1919:2008Natur.456..663H
1735:10.1038/nature07483
1727:2008Natur.456..663H
810:histone acetylation
2831:10.1101/gr.6.9.791
1339:
960:ENSMUSG00000027678
748:Biological process
707:Cellular component
621:Molecular function
450:buccal mucosa cell
3906:
3905:
3543:
3542:
2660:10.1021/bi011764+
2301:10.1021/bi010379h
1356:Androgen receptor
1283:endocrine therapy
1256:nuclear receptors
1197:
1196:
1193:
1192:
1166:
1165:
1131:
1130:
1112:
1111:
1074:
1073:
1049:
1048:
1011:
1010:
992:
991:
966:
965:
947:
946:
921:
920:
902:
901:
850:
849:
605:
604:
601:
600:
556:
555:
543:
542:
516:medulla of thymus
481:
480:
462:bone marrow cells
379:
378:
278:
277:
173:NCOA3 - orthologs
105:
104:
101:
100:
61:Ortholog search:
16:(Redirected from
3936:
3802:Hairless homolog
3729:AIB/SRC-3/TRAM-1
3719:GRIP1/SRC-2/TIF2
3659:Drip205/Trap220)
3570:
3563:
3556:
3547:
3529:
3509:
3502:
3495:
3486:
3480:
3470:
3445:
3435:
3402:
3392:
3367:
3357:
3347:
3314:
3304:
3279:
3250:
3232:
3207:
3197:
3164:
3154:
3144:
3135:(47): 30847–50.
3119:
3082:
3044:
3034:
3025:(44): 27629–34.
3009:
2991:
2966:
2933:
2923:
2913:
2880:
2843:
2833:
2808:
2786:
2776:
2743:
2672:
2671:
2643:
2637:
2636:
2618:
2594:
2588:
2587:
2585:
2583:
2575:
2564:Retraction Watch
2543:
2533:
2509:
2503:
2502:
2492:
2468:
2462:
2461:
2451:
2419:
2413:
2412:
2402:
2378:
2372:
2371:
2361:
2351:
2334:(23): 12536–40.
2319:
2313:
2312:
2284:
2275:
2274:
2272:
2270:
2262:
2236:
2226:
2194:
2183:
2182:
2146:
2140:
2139:
2129:
2093:
2080:
2079:
2069:
2060:(17): 17319–28.
2045:
2039:
2038:
2028:
1996:
1990:
1989:
1979:
1955:
1949:
1948:
1938:
1898:
1892:
1891:
1881:
1853:
1847:
1846:
1836:
1812:
1806:
1805:
1795:
1763:
1757:
1756:
1746:
1706:
1700:
1699:
1697:
1696:
1677:
1671:
1670:
1660:
1651:(44): 27629–34.
1636:
1630:
1629:
1597:
1591:
1590:
1580:
1571:(44): 27629–34.
1556:
1550:
1549:
1517:
1511:
1510:
1499:
1493:
1492:
1481:
1475:
1465:
1454:
1444:
1244:nuclear receptor
1179:
1178:
1150:
1143:
1126:
1116:
1107:
1083:
1079:RefSeq (protein)
1069:
1053:
1044:
1020:
996:
977:
951:
932:
906:
887:
856:
611:
597:
588:
581:
574:
567:
552:
504:secondary oocyte
492:
490:Top expressed in
485:
438:secondary oocyte
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
75:
69:
48:
47:
42:
30:
21:
3944:
3943:
3939:
3938:
3937:
3935:
3934:
3933:
3909:
3908:
3907:
3902:
3881:
3865:
3774:
3703:
3579:
3574:
3544:
3539:
3536:
3530:
3516:
3513:
3483:
3448:
3412:Mol. Cell. Biol
3405:
3370:
3317:
3295:(12): 2151–62.
3289:Mol. Endocrinol
3282:
3262:(20): 3519–27.
3253:
3210:
3180:(22): 3488–98.
3167:
3122:
3085:
3057:(5351): 703–7.
3047:
3012:
2969:
2949:(5328): 965–8.
2936:
2896:(16): 8479–84.
2883:
2846:
2811:
2799:(15): 3446–50.
2789:
2753:Mol. Cell. Biol
2746:
2709:
2705:
2703:Further reading
2680:
2675:
2645:
2644:
2640:
2596:
2595:
2591:
2577:
2569:
2567:
2544:
2524:(43): 33201–4.
2511:
2510:
2506:
2477:Mol. Endocrinol
2470:
2469:
2465:
2434:(17): 6210–20.
2428:Mol. Cell. Biol
2421:
2420:
2416:
2380:
2379:
2375:
2321:
2320:
2316:
2295:(23): 6756–65.
2286:
2285:
2278:
2264:
2256:
2254:
2237:
2196:
2195:
2186:
2157:(6): L1066-74.
2148:
2147:
2143:
2112:(10): 3549–61.
2106:Mol. Cell. Biol
2095:
2094:
2083:
2047:
2046:
2042:
2011:(12): 1928–36.
1998:
1997:
1993:
1957:
1956:
1952:
1913:(7222): 663–6.
1900:
1899:
1895:
1855:
1854:
1850:
1821:Cancer Research
1814:
1813:
1809:
1765:
1764:
1760:
1721:(7222): 663–6.
1708:
1707:
1703:
1694:
1692:
1679:
1678:
1674:
1638:
1637:
1633:
1612:(5328): 965–8.
1599:
1598:
1594:
1558:
1557:
1553:
1532:(5328): 965–8.
1519:
1518:
1514:
1501:
1500:
1496:
1483:
1482:
1478:
1466:
1457:
1445:
1436:
1432:
1427:
1344:
1264:
1236:
1188:View/Edit Mouse
1183:View/Edit Human
1146:
1139:
1136:Location (UCSC)
1124:
1103:
1099:
1095:
1091:
1065:
1061:
1040:
1036:
1032:
1028:
941:ENSG00000124151
834:
743:
702:
658:protein binding
593:
583:
582:
576:
575:
548:
539:
534:
530:
528:ascending aorta
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
464:
460:
456:
452:
448:
444:
440:
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3942:
3940:
3932:
3931:
3926:
3921:
3911:
3910:
3904:
3903:
3901:
3900:
3895:
3889:
3887:
3883:
3882:
3880:
3879:
3869:
3844:
3839:
3834:
3829:
3824:
3819:
3809:
3804:
3799:
3784:
3782:
3776:
3775:
3773:
3772:
3762:
3752:
3742:
3732:
3722:
3712:
3698:
3684:
3670:
3665:
3660:
3650:
3632:
3618:
3613:
3608:
3589:
3587:
3581:
3580:
3575:
3573:
3572:
3565:
3558:
3550:
3541:
3540:
3538:
3537:
3531:
3524:
3521:
3518:
3517:
3514:
3512:
3511:
3504:
3497:
3489:
3482:
3481:
3461:(9): 3440–50.
3446:
3418:(14): 5041–7.
3403:
3383:(8): 5976–82.
3368:
3315:
3280:
3251:
3208:
3165:
3120:
3083:
3045:
3010:
2967:
2934:
2881:
2844:
2824:(9): 791–806.
2809:
2787:
2759:(7): 3479–86.
2744:
2706:
2704:
2701:
2700:
2699:
2691:
2679:
2678:External links
2676:
2674:
2673:
2638:
2589:
2504:
2463:
2414:
2393:(8): 5976–82.
2373:
2314:
2276:
2209:(6): 1341–52.
2184:
2141:
2081:
2040:
1991:
1970:(9): 3440–50.
1950:
1893:
1848:
1827:(13): 5450–9.
1807:
1778:(14): 5041–7.
1758:
1701:
1672:
1631:
1592:
1551:
1512:
1494:
1476:
1455:
1433:
1431:
1428:
1426:
1425:
1419:
1413:
1407:
1401:
1395:
1389:
1383:
1377:
1371:
1365:
1359:
1352:
1343:
1340:
1263:
1260:
1235:
1232:
1203:also known as
1195:
1194:
1191:
1190:
1185:
1175:
1174:
1168:
1167:
1164:
1163:
1161:
1159:
1152:
1151:
1144:
1137:
1133:
1132:
1129:
1128:
1120:
1119:
1113:
1110:
1109:
1087:
1086:
1080:
1076:
1075:
1072:
1071:
1057:
1056:
1050:
1047:
1046:
1024:
1023:
1017:
1013:
1012:
1009:
1008:
1000:
999:
993:
990:
989:
981:
980:
974:
968:
967:
964:
963:
955:
954:
948:
945:
944:
936:
935:
929:
923:
922:
919:
918:
910:
909:
903:
900:
899:
891:
890:
884:
878:
877:
872:
867:
863:
862:
852:
851:
848:
847:
836:
835:
833:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
751:
749:
745:
744:
742:
741:
736:
731:
726:
721:
716:
710:
708:
704:
703:
701:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
607:
606:
603:
602:
599:
598:
590:
589:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
536:lacrimal gland
533:
532:primary oocyte
529:
525:
521:
517:
513:
509:
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3941:
3930:
3927:
3925:
3922:
3920:
3917:
3916:
3914:
3899:
3896:
3894:
3891:
3890:
3888:
3884:
3877:
3873:
3870:
3868:
3863:
3859:
3855:
3851:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3817:
3813:
3810:
3808:
3805:
3803:
3800:
3797:
3793:
3789:
3786:
3785:
3783:
3781:
3777:
3770:
3766:
3763:
3760:
3756:
3753:
3750:
3746:
3743:
3740:
3736:
3733:
3730:
3726:
3723:
3720:
3716:
3713:
3710:
3706:
3702:
3699:
3696:
3692:
3688:
3685:
3682:
3678:
3674:
3671:
3669:
3666:
3664:
3661:
3658:
3654:
3651:
3648:
3644:
3640:
3636:
3633:
3630:
3626:
3622:
3619:
3617:
3614:
3612:
3609:
3606:
3602:
3598:
3594:
3591:
3590:
3588:
3586:
3582:
3578:
3571:
3566:
3564:
3559:
3557:
3552:
3551:
3548:
3534:
3528:
3523:
3519:
3510:
3505:
3503:
3498:
3496:
3491:
3490:
3487:
3478:
3474:
3469:
3464:
3460:
3456:
3455:Endocrinology
3452:
3447:
3443:
3439:
3434:
3429:
3425:
3421:
3417:
3413:
3409:
3404:
3400:
3396:
3391:
3386:
3382:
3378:
3377:J. Biol. Chem
3374:
3369:
3365:
3361:
3356:
3351:
3346:
3341:
3337:
3333:
3330:(3): 1020–5.
3329:
3325:
3321:
3316:
3312:
3308:
3303:
3298:
3294:
3290:
3286:
3281:
3277:
3273:
3269:
3265:
3261:
3257:
3252:
3248:
3244:
3240:
3236:
3231:
3226:
3223:(5): 675–86.
3222:
3218:
3214:
3209:
3205:
3201:
3196:
3191:
3187:
3183:
3179:
3175:
3171:
3166:
3162:
3158:
3153:
3148:
3143:
3138:
3134:
3130:
3129:J. Biol. Chem
3126:
3121:
3117:
3113:
3109:
3105:
3101:
3097:
3093:
3089:
3084:
3080:
3076:
3072:
3068:
3064:
3060:
3056:
3052:
3046:
3042:
3038:
3033:
3028:
3024:
3020:
3019:J. Biol. Chem
3016:
3011:
3007:
3003:
2999:
2995:
2990:
2985:
2982:(3): 569–80.
2981:
2977:
2973:
2968:
2964:
2960:
2956:
2952:
2948:
2944:
2940:
2935:
2931:
2927:
2922:
2917:
2912:
2907:
2903:
2899:
2895:
2891:
2887:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2855:(1): 114–22.
2854:
2850:
2845:
2841:
2837:
2832:
2827:
2823:
2819:
2815:
2810:
2806:
2802:
2798:
2794:
2788:
2784:
2780:
2775:
2770:
2766:
2762:
2758:
2754:
2750:
2745:
2741:
2737:
2733:
2729:
2725:
2721:
2718:(1–5): 3–14.
2717:
2713:
2708:
2707:
2702:
2698:
2695:
2692:
2689:
2685:
2682:
2681:
2677:
2669:
2665:
2661:
2657:
2654:(8): 2500–8.
2653:
2649:
2642:
2639:
2634:
2630:
2626:
2622:
2617:
2612:
2609:(3): 569–80.
2608:
2604:
2600:
2593:
2590:
2581:
2573:
2566:
2565:
2560:
2556:
2552:
2548:
2541:
2537:
2532:
2527:
2523:
2519:
2518:J. Biol. Chem
2515:
2508:
2505:
2500:
2496:
2491:
2486:
2483:(4): 501–11.
2482:
2478:
2474:
2467:
2464:
2459:
2455:
2450:
2445:
2441:
2437:
2433:
2429:
2425:
2418:
2415:
2410:
2406:
2401:
2396:
2392:
2388:
2387:J. Biol. Chem
2384:
2377:
2374:
2369:
2365:
2360:
2355:
2350:
2345:
2341:
2337:
2333:
2329:
2325:
2318:
2315:
2310:
2306:
2302:
2298:
2294:
2290:
2283:
2281:
2277:
2268:
2260:
2253:
2249:
2245:
2241:
2234:
2230:
2225:
2220:
2216:
2212:
2208:
2204:
2200:
2193:
2191:
2189:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2145:
2142:
2137:
2133:
2128:
2123:
2119:
2115:
2111:
2107:
2103:
2099:
2092:
2090:
2088:
2086:
2082:
2077:
2073:
2068:
2063:
2059:
2055:
2054:J. Biol. Chem
2051:
2044:
2041:
2036:
2032:
2027:
2022:
2018:
2014:
2010:
2006:
2005:Br. J. Cancer
2002:
1995:
1992:
1987:
1983:
1978:
1973:
1969:
1965:
1964:Endocrinology
1961:
1954:
1951:
1946:
1942:
1937:
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1897:
1894:
1889:
1885:
1880:
1875:
1872:(5): 353–61.
1871:
1867:
1863:
1859:
1858:Hilsenbeck SG
1852:
1849:
1844:
1840:
1835:
1830:
1826:
1822:
1818:
1811:
1808:
1803:
1799:
1794:
1789:
1785:
1781:
1777:
1773:
1769:
1762:
1759:
1754:
1750:
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520:ciliary body
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371:166,073,242
358:165,992,636
132:External IDs
83:
3515:PDB gallery
3256:J. Cell Sci
3088:Clin. Genet
1685:Cordis News
1645:J Biol Chem
1312:fulvestrant
1240:coactivator
719:nucleoplasm
508:granulocyte
466:oral cavity
350:2|2 H3
270:47,656,877
257:47,501,887
110:Identifiers
3913:Categories
2849:Hum. Genet
2818:Genome Res
2793:Cancer Res
1695:2008-11-14
1474:, May 2017
1453:, May 2017
1430:References
1303:PIK3CA/AKT
416:(ortholog)
153:HomoloGene
3653:DRIP/TRAP
3174:Genes Dev
2580:retracted
2572:retracted
2267:retracted
2259:retracted
1308:tamoxifen
1272:tamoxifen
1105:NP_858045
1101:NP_006525
1063:NM_008679
1042:NM_006534
1030:NM_181659
860:Orthologs
714:cytoplasm
161:GeneCards
3621:p300-CBP
3477:10965917
3442:10866661
3399:10681591
3364:10655477
3311:10598588
3276:10504300
3247:14697597
3239:10490106
3006:15284825
2877:25999127
2740:40981759
2732:12650696
2668:11851396
2633:15284825
2559:24143011
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2499:11266503
2458:12917342
2409:10681591
2368:11050174
2309:11389589
2252:25452582
2233:11250900
2179:27872061
2171:11076796
2136:11971985
2076:14966121
2035:11747336
1986:10965917
1945:19005469
1888:12618500
1843:18593948
1802:10866661
1753:19005469
1470:–
1449:–
1348:interact
1323:HER2/neu
1287:HER2/neu
1252:histones
1234:Function
1172:Wikidata
839:Sources:
249:20q13.12
3898:SWI/SNF
3769:ERAP140
3701:TGFB1I1
3332:Bibcode
3204:9832502
3161:9812974
3152:3968904
3116:1315265
3108:9727751
3079:9445475
3059:Bibcode
3051:Science
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2963:9252329
2943:Science
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2898:Bibcode
2869:9225980
2840:8889548
2805:8758910
2783:7791754
2625:9267036
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2098:Tsai MJ
2026:2364015
1936:2920208
1915:Bibcode
1744:2920208
1723:Bibcode
1667:9346901
1626:9252329
1606:Science
1587:9346901
1546:9252329
1526:Science
1472:Ensembl
1451:Ensembl
1301:and/or
1209:protein
972:UniProt
927:Ensembl
866:Species
845:QuickGO
734:cytosol
729:nucleus
391:pattern
149:1276535
117:Aliases
3822:PELP-1
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3687:PPARGC
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524:morula
500:zygote
454:nipple
141:601937
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3867:NCOR1
3842:SIN3B
3837:SIN3A
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3755:NCOA6
3745:NCOA5
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3735:NCOA4
3725:NCOA3
3715:NCOA2
3709:SRC-1
3705:NCOA1
3625:EP300
3616:CARM1
3611:BCAS3
3433:85954
3355:15508
3243:S2CID
3112:S2CID
3002:S2CID
2921:22964
2873:S2CID
2736:S2CID
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1404:IKBKG
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915:17979
875:Mouse
870:Human
841:Amigo
512:blood
414:Mouse
407:Human
354:Start
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253:Start
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165:NCOA3
124:NCOA3
33:NCOA3
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