309:
286:
183:
208:
315:
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2394:
1310:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA), thus confining the holoenzyme to discrete locations within the cell. The AKAP13 gene encodes a member of the AKAP family
50:
2285:
Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, et al. (July 2003). "The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein".
1318:
characteristic of Rho family GEFs, while only the longer two isoforms also contain the AKAP domain. Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling.
2323:
Hornemann T, Kempa S, Himmel M, Hayess K, Fürst DO, Wallimann T (September 2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein".
115:, A kinase (PRKA) anchor protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchoring protein 13, A-kinase anchor protein 13
1493:
Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, et al. (May 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action".
2256:
Tan YC, Wu H, Wang WN, Zheng Y, Wang ZX (November 2002). "Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors".
322:
221:
1798:"Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation"
1898:"Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain"
1538:"Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif"
2024:
Toksoz D, Williams DA (February 1994). "Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products".
884:
865:
144:
2463:
2439:
1839:"Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring"
2047:"Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting"
1991:"Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5"
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1472:
1454:
47:
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1941:
308:
1315:
1208:
1186:
1108:
1115:
285:
1580:
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1441:
1420:
1314:
Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms. All three contain the
207:
182:
1947:
1437:
1416:
124:
1328:
1255:
321:
220:
1236:, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific
2432:
1372:
1296:
314:
213:
1647:
Dutt P, Nguyen N, Toksoz D (February 2004). "Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase".
1377:
1269:
929:
132:
2354:"A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes"
2178:"The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway"
1685:
Thumkeo D, Watanabe S, Narumiya S (Oct–Nov 2013). "Physiological roles of Rho and Rho effectors in mammals".
1367:
1340:
910:
1259:
1233:
1601:"AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation"
2425:
1387:
1229:
196:
1284:(also known as LARG). GPCR-regulated AKAP13 (and these related GEF proteins) acts as an effector for G
1850:
2223:"Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling"
1953:
1062:
1003:
111:
2311:
1518:
1237:
156:
1091:
1070:
1066:
1036:
1015:
1011:
1007:
999:
2221:
Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, et al. (November 2001).
1761:
Kozasa T (April 2001). "Regulation of G protein-mediated signal transduction by RGS proteins".
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2012:
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1510:
104:
40:
2409:
1536:
Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (August 1991).
1232:. But when acted on by Rho GEF proteins such as AKAP13, this GDP is released and replaced by
2365:
2332:
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2234:
2199:
2189:
2154:
2146:
2111:
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2002:
1909:
1868:
1858:
1809:
1770:
1733:
1694:
1656:
1612:
1549:
1502:
1392:
1181:. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc)
750:
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
401:
332:
276:
231:
152:
2135:"A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes"
1837:
Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003).
1244:
to regulate cellular functions. In particular, active Rho is a major regulator of the cell
2045:
Sterpetti P, Hack AA, Bashar MP, Park B, Cheng SD, Knoll JH, et al. (February 1999).
1796:
Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, et al. (November 2002).
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1189:
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2222:
2159:
2134:
2133:
Newlon MG, Roy M, Morikis D, Carr DW, Westphal R, Scott JD, Jennings PA (April 2001).
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2007:
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597:
592:
2452:
2405:
1969:
1382:
1316:
Dbl oncogene homology (DH) domain plus
Pleckstrin homology (PH) domain (DH/PH domain)
1196:
579:
2315:
1522:
136:
2090:"Physical and functional interactions of Galphaq with Rho and its exchange factors"
1722:"RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?"
1248:
1219:
1215:
394:
173:
160:
2088:
Sagi SA, Seasholtz TM, Kobiashvili M, Wilson BA, Toksoz D, Brown JH (May 2001).
1477:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1459:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2299:
1843:
Proceedings of the
National Academy of Sciences of the United States of America
1698:
1254:
AKAP13 is a member of a group of four RhoGEF proteins known to be activated by
477:
2150:
1226:
293:
190:
140:
1989:
Hausken ZE, Coghlan VM, Hastings CA, Reimann EM, Scott JD (September 1994).
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2016:
1923:
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1514:
1155:
1281:
1277:
1182:
1139:
974:
955:
1292:
G proteins. Unlike the other three members, AKAP13 does not function as
1207:
A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is
1150:
1974:
1964:
1355:
1335:
1273:
1241:
1223:
1171:
941:
896:
1896:
Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (July 1992).
81:
77:
73:
69:
1123:
851:
2393:
1350:
1345:
1245:
1311:
since the protein binds tightly to PKA, especially in the heart.
814:
810:
2401:
1212:
1193:
1178:
128:
1959:
Overview of all the structural information available in the
735:
positive regulation of I-kappaB kinase/NF-kappaB signaling
384:
2413:
1581:"Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13"
800:
cell growth involved in cardiac muscle cell development
745:
regulation of small GTPase mediated signal transduction
720:
regulation of glucocorticoid mediated signaling pathway
725:
positive regulation of Rho protein signal transduction
549:
2176:Driggers PH, Segars JH, Rubino DM (December 2001).
1084:
1055:
1029:
992:
2352:Chen LY, Zuraw BL, Ye RD, Pan ZK (February 2004).
1599:Diviani D, Soderling J, Scott JD (November 2001).
1433:
1431:
1429:
1412:
1410:
1408:
331:
230:
1720:Fukuhara S, Chikumi H, Gutkind JS (March 2001).
1680:
1678:
16:Protein-coding gene in the species Homo sapiens
1642:
1640:
1638:
1636:
1594:
1592:
1590:
1438:GRCm38: Ensembl release 89: ENSMUSG00000066406
1185:, and ARHGEF13/RhoGEF13 because it contains a
2433:
1488:
1486:
770:regulation of Rho protein signal transduction
8:
790:G protein-coupled receptor signaling pathway
1417:GRCh38: Ensembl release 89: ENSG00000170776
1299:to increase the rate of GTP hydrolysis of G
1222:protein that is inactive when bound to the
2440:
2426:
825:
795:positive regulation of MAP kinase activity
603:guanyl-nucleotide exchange factor activity
575:
372:
271:
168:
58:
2369:
2238:
2203:
2193:
2158:
2115:
2105:
2070:
2006:
1913:
1872:
1862:
1813:
1737:
1616:
1553:
1575:
1573:
1187:guanine nucleotide exchange factor (GEF)
760:positive regulation of apoptotic process
705:regulation of cardiac muscle hypertrophy
1404:
628:cAMP-dependent protein kinase activity
18:
780:regulation of protein kinase activity
740:adrenergic receptor signaling pathway
336:
297:
292:
235:
194:
189:
7:
2390:
2388:
1973:(A-kinase anchor protein 13) at the
730:regulation of sarcomere organization
2358:The Journal of Biological Chemistry
2182:The Journal of Biological Chemistry
2094:The Journal of Biological Chemistry
1995:The Journal of Biological Chemistry
1902:The Journal of Biological Chemistry
1802:The Journal of Biological Chemistry
1605:The Journal of Biological Chemistry
1542:The Journal of Biological Chemistry
765:cardiac muscle cell differentiation
2412:. You can help Knowledge (XXG) by
1209:guanine nucleotide exchange factor
1174:that in humans, is encoded by the
1081:
1052:
1026:
989:
965:
946:
920:
901:
875:
856:
689:intracellular anatomical structure
554:
472:
410:
389:
14:
1297:GTPase-activating proteins (GAPs)
715:intracellular signal transduction
2392:
1687:European Journal of Cell Biology
1280:(also known as PDZ-RhoGEF), and
320:
313:
307:
284:
219:
212:
206:
181:
659:perinuclear region of cytoplasm
2464:Human chromosome 15 gene stubs
2051:Molecular and Cellular Biology
538:More reference expression data
1:
2337:10.1016/S0022-2836(03)00921-5
2270:10.1016/S0003-2697(02)00382-2
2240:10.1016/S0014-5793(01)02995-7
2008:10.1016/S0021-9258(19)51074-2
1915:10.1016/S0021-9258(18)42221-1
1775:10.1016/S0024-3205(01)01020-7
1661:10.1016/S0898-6568(03)00132-3
1555:10.1016/S0021-9258(18)98665-5
1276:(also known as p115-RhoGEF),
305:
204:
2459:Genes on human chromosome 15
2325:Journal of Molecular Biology
598:MAP-kinase scaffold activity
2469:A-kinase-anchoring proteins
1256:G protein coupled receptors
679:cortical actin cytoskeleton
2485:
2387:
2300:10.1182/blood-2003-01-0260
1952:gene details page in the
1699:10.1016/j.ejcb.2013.09.002
1373:G protein-coupled receptor
1168:A-kinase anchor protein 13
623:signal transducer activity
613:molecular adaptor activity
1473:"Mouse PubMed Reference:"
1455:"Human PubMed Reference:"
1327:AKAP13 has been shown to
1270:heterotrimeric G proteins
1197:small GTP-binding protein
1154:
1149:
1145:
1138:
1122:
1103:
1088:
1059:
1048:
1033:
996:
985:
972:
968:
953:
949:
940:
927:
923:
908:
904:
895:
882:
878:
863:
859:
850:
835:
828:
824:
808:
578:
574:
562:
557:
548:
535:
484:
475:
422:
413:
383:
375:
371:
354:
341:
304:
283:
274:
270:
253:
240:
203:
180:
171:
167:
122:
119:
109:
102:
97:
66:
61:
44:
39:
34:
30:
26:
21:
1378:Heterotrimeric G protein
1109:Chr 15: 85.38 – 85.75 Mb
618:protein kinase A binding
426:tendon of biceps brachii
2258:Analytical Biochemistry
2151:10.1093/emboj/20.7.1651
1864:10.1073/pnas.0330734100
1368:Second messenger system
1341:Estrogen receptor alpha
1116:Chr 7: 75.46 – 75.75 Mb
775:protein phosphorylation
2371:10.1074/jbc.M309542200
2195:10.1074/jbc.M106927200
2107:10.1074/jbc.M008961200
1815:10.1074/jbc.M202447200
1739:10.1038/sj.onc.1204182
1618:10.1074/jbc.M106629200
1507:10.1038/sj.onc.1201783
492:lumbar spinal ganglion
488:mesenteric lymph nodes
2063:10.1128/mcb.19.2.1334
1388:Rho family of GTPases
197:Chromosome 15 (human)
1946:genome location and
299:Chromosome 7 (mouse)
62:List of PDB id codes
35:Available structures
1954:UCSC Genome Browser
1855:2003PNAS..100.4445A
1649:Cellular Signalling
500:submandibular gland
442:epithelium of colon
2400:This article on a
1769:(19–20): 2309–17.
1218:protein. Rho is a
930:ENSMUSG00000066406
698:Biological process
654:actin cytoskeleton
637:Cellular component
586:Molecular function
520:extraocular muscle
458:tail of epididymis
434:lower lobe of lung
161:AKAP13 - orthologs
2421:
2420:
1693:(10–11): 303–15.
1272:. The others are
1165:
1164:
1161:
1160:
1134:
1133:
1099:
1098:
1078:
1077:
1044:
1043:
1023:
1022:
981:
980:
962:
961:
936:
935:
917:
916:
891:
890:
872:
871:
820:
819:
755:heart development
593:metal ion binding
570:
569:
566:
565:
544:
543:
531:
530:
469:
468:
367:
366:
266:
265:
93:
92:
89:
88:
45:Ortholog search:
2476:
2442:
2435:
2428:
2396:
2389:
2383:
2373:
2348:
2319:
2281:
2252:
2242:
2217:
2207:
2197:
2172:
2162:
2139:The EMBO Journal
2129:
2119:
2109:
2100:(18): 15445–52.
2084:
2074:
2041:
2020:
2010:
2001:(39): 24245–51.
1928:
1927:
1917:
1908:(19): 13376–82.
1893:
1887:
1886:
1876:
1866:
1834:
1828:
1827:
1817:
1808:(47): 45361–70.
1793:
1787:
1786:
1758:
1752:
1751:
1741:
1717:
1711:
1710:
1682:
1673:
1672:
1644:
1631:
1630:
1620:
1611:(47): 44247–57.
1596:
1585:
1584:
1577:
1568:
1567:
1557:
1548:(22): 14188–92.
1533:
1527:
1526:
1490:
1481:
1480:
1469:
1463:
1462:
1451:
1445:
1435:
1424:
1414:
1393:Protein kinase A
1307:alpha proteins.
1147:
1146:
1118:
1111:
1094:
1082:
1073:
1053:
1049:RefSeq (protein)
1039:
1027:
1018:
990:
966:
947:
921:
902:
876:
857:
826:
710:bone development
576:
555:
540:
480:
478:Top expressed in
473:
418:
416:Top expressed in
411:
390:
373:
363:
350:
339:
324:
317:
311:
300:
288:
272:
262:
249:
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185:
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107:
84:
59:
53:
32:
31:
19:
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2483:
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2473:
2449:
2448:
2447:
2446:
2386:
2351:
2322:
2284:
2255:
2220:
2188:(50): 46792–7.
2175:
2132:
2087:
2044:
2023:
1988:
1984:
1982:Further reading
1937:
1932:
1931:
1895:
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1634:
1598:
1597:
1588:
1579:
1578:
1571:
1535:
1534:
1530:
1501:(19): 2513–26.
1492:
1491:
1484:
1471:
1470:
1466:
1453:
1452:
1448:
1436:
1427:
1415:
1406:
1401:
1364:
1325:
1306:
1302:
1291:
1287:
1267:
1263:
1258:coupled to the
1205:
1156:View/Edit Mouse
1151:View/Edit Human
1114:
1107:
1104:Location (UCSC)
1090:
1069:
1065:
1061:
1035:
1014:
1010:
1006:
1002:
998:
911:ENSG00000170776
804:
693:
632:
608:protein binding
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510:
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502:
498:
494:
490:
476:
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462:right ventricle
460:
456:
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448:
446:visceral pleura
444:
440:
436:
432:
430:Achilles tendon
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414:
358:
345:
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275:Gene location (
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217:
195:
172:Gene location (
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110:
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68:
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17:
12:
11:
5:
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2450:
2445:
2444:
2437:
2430:
2422:
2419:
2418:
2397:
2385:
2384:
2364:(8): 7208–12.
2349:
2320:
2282:
2253:
2218:
2173:
2145:(7): 1651–62.
2130:
2085:
2057:(2): 1334–45.
2042:
2021:
1985:
1983:
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1978:
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1936:
1935:External links
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1929:
1888:
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1732:(13): 1661–8.
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1211:(GEF) for the
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785:nuclear export
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674:actin filament
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640:
638:
634:
633:
631:
630:
625:
620:
615:
610:
605:
600:
595:
589:
587:
583:
582:
572:
571:
568:
567:
564:
563:
560:
559:
552:
546:
545:
542:
541:
533:
532:
529:
528:
526:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
482:
481:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
407:
406:
398:
387:
381:
380:
377:RNA expression
369:
368:
365:
364:
356:
352:
351:
343:
340:
335:
329:
328:
319:
312:
306:
302:
301:
296:
290:
289:
281:
280:
268:
267:
264:
263:
255:
251:
250:
242:
239:
234:
228:
227:
218:
211:
205:
201:
200:
193:
187:
186:
178:
177:
165:
164:
121:
117:
116:
108:
100:
99:
95:
94:
91:
90:
87:
86:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2481:
2470:
2467:
2465:
2462:
2460:
2457:
2456:
2454:
2443:
2438:
2436:
2431:
2429:
2424:
2423:
2417:
2415:
2411:
2407:
2406:chromosome 15
2403:
2398:
2395:
2391:
2381:
2377:
2372:
2367:
2363:
2359:
2355:
2350:
2346:
2342:
2338:
2334:
2331:(4): 877–87.
2330:
2326:
2321:
2317:
2313:
2309:
2305:
2301:
2297:
2293:
2289:
2283:
2279:
2275:
2271:
2267:
2264:(2): 156–62.
2263:
2259:
2254:
2250:
2246:
2241:
2236:
2232:
2228:
2224:
2219:
2215:
2211:
2206:
2201:
2196:
2191:
2187:
2183:
2179:
2174:
2170:
2166:
2161:
2156:
2152:
2148:
2144:
2140:
2136:
2131:
2127:
2123:
2118:
2113:
2108:
2103:
2099:
2095:
2091:
2086:
2082:
2078:
2073:
2068:
2064:
2060:
2056:
2052:
2048:
2043:
2039:
2035:
2031:
2027:
2022:
2018:
2014:
2009:
2004:
2000:
1996:
1992:
1987:
1986:
1981:
1976:
1972:
1971:
1966:
1962:
1958:
1955:
1951:
1950:
1945:
1944:
1939:
1938:
1934:
1925:
1921:
1916:
1911:
1907:
1903:
1899:
1892:
1889:
1884:
1880:
1875:
1870:
1865:
1860:
1856:
1852:
1848:
1844:
1840:
1833:
1830:
1825:
1821:
1816:
1811:
1807:
1803:
1799:
1792:
1789:
1784:
1780:
1776:
1772:
1768:
1764:
1763:Life Sciences
1757:
1754:
1749:
1745:
1740:
1735:
1731:
1727:
1723:
1716:
1713:
1708:
1704:
1700:
1696:
1692:
1688:
1681:
1679:
1675:
1670:
1666:
1662:
1658:
1654:
1650:
1643:
1641:
1639:
1637:
1633:
1628:
1624:
1619:
1614:
1610:
1606:
1602:
1595:
1593:
1591:
1587:
1582:
1576:
1574:
1570:
1565:
1561:
1556:
1551:
1547:
1543:
1539:
1532:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1489:
1487:
1483:
1478:
1474:
1468:
1465:
1460:
1456:
1450:
1447:
1443:
1439:
1434:
1432:
1430:
1426:
1422:
1418:
1413:
1411:
1409:
1405:
1398:
1394:
1391:
1389:
1386:
1384:
1383:Small GTPases
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1365:
1361:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1333:
1332:
1330:
1322:
1320:
1317:
1312:
1308:
1298:
1295:
1283:
1279:
1275:
1271:
1268:
1257:
1252:
1250:
1247:
1243:
1240:proteins and
1239:
1235:
1231:
1228:
1225:
1221:
1217:
1214:
1210:
1202:
1200:
1198:
1195:
1191:
1188:
1184:
1180:
1177:
1173:
1169:
1157:
1152:
1148:
1144:
1141:
1137:
1130:
1128:
1125:
1121:
1117:
1113:
1110:
1106:
1102:
1095:
1093:
1087:
1083:
1080:
1074:
1072:
1068:
1064:
1058:
1054:
1051:
1047:
1040:
1038:
1032:
1028:
1025:
1019:
1017:
1013:
1009:
1005:
1001:
995:
991:
988:
986:RefSeq (mRNA)
984:
977:
976:
971:
967:
964:
958:
957:
952:
948:
945:
943:
939:
932:
931:
926:
922:
919:
913:
912:
907:
903:
900:
898:
894:
887:
886:
881:
877:
874:
868:
867:
862:
858:
855:
853:
849:
846:
843:
841:
838:
834:
831:
827:
823:
816:
812:
807:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
702:
700:
697:
696:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
590:
588:
585:
584:
581:
580:Gene ontology
577:
573:
561:
556:
553:
551:
547:
539:
534:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
486:
483:
479:
474:
471:
461:
457:
454:apex of heart
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
408:
405:
403:
399:
397:
396:
392:
391:
388:
386:
382:
378:
374:
370:
362:
357:
353:
349:
344:
334:
330:
323:
316:
310:
303:
295:
291:
287:
282:
278:
273:
269:
261:
256:
252:
248:
243:
233:
229:
222:
215:
209:
202:
198:
192:
188:
184:
179:
175:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
118:
113:
106:
101:
96:
85:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2414:expanding it
2399:
2361:
2357:
2328:
2324:
2294:(2): 621–9.
2291:
2287:
2261:
2257:
2233:(3): 264–8.
2230:
2227:FEBS Letters
2226:
2185:
2181:
2142:
2138:
2097:
2093:
2054:
2050:
2032:(2): 621–8.
2029:
2025:
1998:
1994:
1968:
1948:
1942:
1905:
1901:
1891:
1846:
1842:
1832:
1805:
1801:
1791:
1766:
1762:
1756:
1729:
1725:
1715:
1690:
1686:
1655:(2): 201–9.
1652:
1648:
1608:
1604:
1545:
1541:
1531:
1498:
1494:
1476:
1467:
1458:
1449:
1326:
1323:Interactions
1313:
1309:
1253:
1249:cytoskeleton
1220:small GTPase
1216:small GTPase
1206:
1175:
1167:
1166:
1089:
1063:NP_001257475
1060:
1034:
1004:NM_001270546
997:
973:
954:
928:
909:
883:
864:
844:
839:
400:
393:
120:External IDs
67:
669:cell cortex
512:granulocyte
504:bone marrow
438:sural nerve
359:75,754,609
346:75,455,534
338:7|7 D1
258:85,749,358
245:85,380,571
98:Identifiers
2453:Categories
1444:, May 2017
1423:, May 2017
1399:References
1294:RGS family
1227:nucleotide
404:(ortholog)
141:HomoloGene
2404:on human
1092:NP_083608
1071:NP_009131
1067:NP_006729
1037:NM_029332
1016:NM_032162
1012:NM_007200
1008:NM_006738
1000:NM_144767
830:Orthologs
684:cytoplasm
149:GeneCards
2380:14660653
2345:12972258
2316:17864975
2308:12663445
2278:12423633
2249:11696353
2214:11579095
2169:11285229
2126:11278452
2026:Oncogene
1883:12672969
1824:12270917
1783:11358341
1748:11313914
1726:Oncogene
1707:24183240
1669:14636890
1627:11546812
1523:20906586
1495:Oncogene
1440:–
1419:–
1362:See also
1329:interact
1282:ARHGEF12
1278:ARHGEF11
1238:effector
1203:Function
1192:for the
1183:oncogene
1140:Wikidata
809:Sources:
644:membrane
2205:4152864
2117:1761691
2081:9891067
2038:8290273
2017:7929081
1975:PDBe-KB
1965:UniProt
1924:1618839
1851:Bibcode
1564:1860836
1515:9627117
1442:Ensembl
1421:Ensembl
1356:PRKAR2A
1336:CTNNAL1
1274:ARHGEF1
1242:enzymes
1224:guanine
1172:protein
942:UniProt
897:Ensembl
836:Species
815:QuickGO
664:nucleus
649:cytosol
450:pylorus
379:pattern
237:15q25.3
137:2676556
105:Aliases
2378:
2343:
2314:
2306:
2276:
2247:
2212:
2202:
2167:
2160:145475
2157:
2124:
2114:
2079:
2072:116062
2069:
2036:
2015:
1970:Q12802
1949:AKAP13
1943:AKAP13
1940:Human
1922:
1881:
1874:153575
1871:
1822:
1781:
1746:
1705:
1667:
1625:
1562:
1521:
1513:
1331:with:
1190:domain
1176:AKAP13
1126:search
1124:PubMed
975:E9Q394
956:Q12802
852:Entrez
550:BioGPS
508:spleen
153:AKAP13
129:604686
112:AKAP13
22:AKAP13
2408:is a
2312:S2CID
2288:Blood
1519:S2CID
1351:GNA13
1346:GNA12
1288:and G
1264:and G
1246:actin
1170:is a
885:75547
866:11214
845:Mouse
840:Human
811:Amigo
524:ankle
496:blood
402:Mouse
395:Human
342:Start
277:Mouse
241:Start
174:Human
2410:stub
2402:gene
2376:PMID
2341:PMID
2304:PMID
2274:PMID
2245:PMID
2210:PMID
2165:PMID
2122:PMID
2077:PMID
2034:PMID
2013:PMID
1963:for
1920:PMID
1879:PMID
1820:PMID
1779:PMID
1744:PMID
1703:PMID
1665:PMID
1623:PMID
1560:PMID
1511:PMID
1213:RhoA
1194:RhoA
1179:gene
516:foot
385:Bgee
333:Band
294:Chr.
232:Band
191:Chr.
145:4903
125:OMIM
82:4D0O
78:4D0N
74:2LG1
70:2DRN
51:RCSB
48:PDBe
2366:doi
2362:279
2333:doi
2329:332
2296:doi
2292:102
2266:doi
2262:310
2235:doi
2231:507
2200:PMC
2190:doi
2186:276
2155:PMC
2147:doi
2112:PMC
2102:doi
2098:276
2067:PMC
2059:doi
2003:doi
1999:269
1961:PDB
1910:doi
1906:267
1869:PMC
1859:doi
1847:100
1810:doi
1806:277
1771:doi
1734:doi
1695:doi
1657:doi
1613:doi
1609:276
1550:doi
1546:266
1503:doi
1234:GTP
1230:GDP
1199:.
558:n/a
355:End
254:End
157:OMA
133:MGI
41:PDB
2455::
2374:.
2360:.
2356:.
2339:.
2327:.
2310:.
2302:.
2290:.
2272:.
2260:.
2243:.
2229:.
2225:.
2208:.
2198:.
2184:.
2180:.
2163:.
2153:.
2143:20
2141:.
2137:.
2120:.
2110:.
2096:.
2092:.
2075:.
2065:.
2055:19
2053:.
2049:.
2028:.
2011:.
1997:.
1993:.
1967::
1918:.
1904:.
1900:.
1877:.
1867:.
1857:.
1845:.
1841:.
1818:.
1804:.
1800:.
1777:.
1767:68
1765:.
1742:.
1730:20
1728:.
1724:.
1701:.
1691:92
1689:.
1677:^
1663:.
1653:16
1651:.
1635:^
1621:.
1607:.
1603:.
1589:^
1572:^
1558:.
1544:.
1540:.
1517:.
1509:.
1499:16
1497:.
1485:^
1475:.
1457:.
1428:^
1407:^
1305:13
1303:/G
1301:12
1290:13
1286:12
1266:13
1262:12
1251:.
813:/
361:bp
348:bp
260:bp
247:bp
155:;
151::
147:;
143::
139:;
135::
131:;
127::
80:,
76:,
72:,
2441:e
2434:t
2427:v
2416:.
2382:.
2368::
2347:.
2335::
2318:.
2298::
2280:.
2268::
2251:.
2237::
2216:.
2192::
2171:.
2149::
2128:.
2104::
2083:.
2061::
2040:.
2030:9
2019:.
2005::
1977:.
1956:.
1926:.
1912::
1885:.
1861::
1853::
1826:.
1812::
1785:.
1773::
1750:.
1736::
1709:.
1697::
1671:.
1659::
1629:.
1615::
1583:.
1566:.
1552::
1525:.
1505::
1479:.
1461:.
1260:G
279:)
176:)
159::
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