332:
309:
2210:
2255:
206:
231:
2240:
2270:
590:
583:
2225:
29:
338:
237:
3022:
3042:
1208:
and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This specific enzyme, AKR1C1, among other reactions, catalyzes the reduction of
55:
2100:
Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids".
2209:
2254:
1625:"Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization"
2130:
Agapova OA, Yang P, Wang WH, Lane DA, Clark AF, Weinstein BI, Hernandez MR (Oct 2003). "Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes".
2500:
2239:
2269:
1853:"Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members"
2495:
2656:
345:
244:
2310:
1695:"Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder"
2550:
124:, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1
2036:
Yang MD, Wu CC, Chiou SH, Chiu CF, Lin TY, Chiang IP, Chow KC (2003). "Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma".
1736:
Qin KN, New MI, Cheng KC (Dec 1993). "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase".
2224:
1582:"Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans"
2344:
2585:
153:
2545:
2007:
Chen CY, Hsu CP, Hsu NY, Shih CS, Lin TY, Chow KC (2002). "Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer".
903:
2218:: Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate
884:
2430:
3116:
2373:
3087:
2485:
3106:
2303:
2189:
1369:
1426:"Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)"
1351:
2580:
2540:
1660:"Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding"
331:
2590:
2557:
1810:"Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells"
1274:
1167:
1499:
2684:
2445:
2358:
1486:
1173:
308:
2741:
2440:
2340:
1103:
1518:
1221:
gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.
1110:
2296:
1425:
2353:
1338:
1317:
2263:: Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules
1974:"Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution"
2679:
2505:
1775:"cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family"
230:
205:
2897:
1505:
1334:
2490:
52:
3012:
1313:
2518:
1524:
133:
2651:
2415:
344:
243:
3080:
2420:
1471:
human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively
1387:
Ciaccio PJ, Tew KD (Jun 1994). "cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase".
1214:
337:
236:
2882:
2998:
2985:
2972:
2959:
2946:
2933:
2920:
2694:
2666:
2638:
2600:
2567:
2470:
2336:
2182:
2892:
1972:
Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX (Nov 2001).
2846:
2789:
2460:
2327:
948:
177:
141:
2794:
2618:
2425:
929:
2510:
2323:
1441:"Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution"
3073:
2815:
2734:
2703:
2465:
2363:
219:
2887:
1896:"Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes"
2248:: Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone
2480:
2475:
2435:
2175:
2288:
2851:
2368:
1530:
1511:
1201:
120:
2784:
2155:
1925:
1761:
1611:
165:
1086:
1065:
1039:
1018:
2278:: Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H)
589:
582:
3111:
2455:
2450:
2147:
2118:
2088:
2053:
2024:
1995:
1960:
1917:
1882:
1839:
1796:
1753:
1724:
1681:
1646:
1603:
1568:
1462:
1404:
113:
45:
3057:
2830:
2825:
2799:
2727:
2623:
2410:
2139:
2110:
2078:
2045:
2016:
1985:
1950:
1907:
1872:
1864:
1829:
1821:
1786:
1745:
1714:
1706:
1671:
1636:
1593:
1558:
1452:
1396:
424:
355:
299:
254:
183:
161:
2877:
2861:
2774:
2628:
2613:
2067:"Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua"
399:
1894:
Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, Ito S (Feb 2000).
1693:
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A (Apr 1994).
28:
3026:
2915:
2856:
2319:
1877:
1852:
1834:
1809:
1719:
1694:
2143:
2114:
2065:
Nakajima T, Yasuda K, Nishizawa M, Okada H, Yoshimura T, Ito S, Kanzaki H (Feb 2003).
1791:
1774:
1676:
1659:
1563:
1546:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
3100:
3053:
2820:
2779:
1912:
1895:
1749:
1641:
1624:
1598:
1581:
1400:
618:
2159:
1929:
1765:
1615:
145:
2769:
1210:
667:
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
417:
196:
1808:
Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, Ishida N (Jan 1996).
169:
2993:
2928:
2764:
1374:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1356:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1273:
aldo-keto reductase family 1 member C3; 3α-hydroxysteroid dehydrogenase type 2;
3021:
1547:"Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics"
1289:
aldo-keto reductase family 1 member C4; 3α-hydroxysteroid dehydrogenase type 1
1261:
aldo-keto reductase family 1 member C2; 3α-hydroxysteroid dehydrogenase type 3
500:
2571:
2523:
316:
213:
149:
2967:
2941:
2642:
848:
560:
438:
383:
370:
282:
269:
157:
2528:
2151:
2122:
2092:
2083:
2066:
2057:
2028:
1999:
1990:
1973:
1964:
1921:
1886:
1466:
1457:
1440:
1955:
1938:
1843:
1800:
1757:
1728:
1685:
1650:
1607:
1572:
1408:
1150:
1145:
1249:
aldo-keto reductase family 1 member C1; 20α-hydroxysteroid dehydrogenase
1134:
993:
974:
2049:
2670:
2383:
2233:: Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone
2020:
1623:
Khanna M, Qin KN, Klisak I, Belkin S, Sparkes RS, Cheng KC (Jan 1995).
960:
915:
1868:
1825:
1773:
Stolz A, Hammond L, Lou H, Takikawa H, Ronk M, Shively JE (May 1993).
1710:
1658:
Lou H, Hammond L, Sharma V, Sparkes RS, Lusis AJ, Stolz A (Mar 1994).
90:
86:
82:
78:
74:
2980:
2750:
2708:
2604:
2403:
2398:
2393:
2378:
1283:
1267:
1255:
1205:
1182:
1118:
870:
3041:
2954:
2533:
1939:"Characterization of a human 20alpha-hydroxysteroid dehydrogenase"
652:
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
833:
829:
3049:
1189:
137:
2723:
2292:
2171:
598:
2167:
2501:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
2719:
1851:
O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999).
1738:
The
Journal of Steroid Biochemistry and Molecular Biology
1586:
The
Journal of Steroid Biochemistry and Molecular Biology
632:
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
407:
3061:
3010:
572:
1937:
Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000).
2906:
2870:
2839:
2808:
2757:
2693:
2665:
2637:
2599:
2566:
2496:
Malate dehydrogenase (oxaloacetate-decarboxylating)
2335:
1389:
Biochimica et
Biophysica Acta (BBA) - Bioenergetics
1079:
1058:
1032:
1011:
2657:Vitamin-K-epoxide reductase (warfarin-insensitive)
1330:
1328:
1326:
1309:
1307:
1305:
1225:Isozymes of aldo-keto reductase family 1 member C
354:
253:
657:androsterone dehydrogenase (B-specific) activity
1439:Dufort I, Labrie F, Luu-The V (February 2001).
16:Protein-coding gene in the species Homo sapiens
1335:GRCm38: Ensembl release 89: ENSMUSG00000021207
3081:
2735:
2304:
2183:
8:
1545:Ciaccio PJ, Jaiswal AK, Tew KD (Jun 1994).
1314:GRCh38: Ensembl release 89: ENSG00000187134
744:cellular response to jasmonic acid stimulus
3088:
3074:
2742:
2728:
2720:
2586:D-lactate dehydrogenase (cytochrome c-553)
2311:
2297:
2289:
2190:
2176:
2168:
844:
614:
395:
294:
191:
63:
2082:
1989:
1954:
1911:
1876:
1833:
1790:
1718:
1675:
1640:
1597:
1562:
1456:
2431:D-malate dehydrogenase (decarboxylating)
1420:
1418:
1228:
662:phenanthrene 9,10-monooxygenase activity
3017:
2205:
1580:Khanna M, Qin KN, Cheng KC (Jun 1995).
1301:
1204:, which consists of more than 40 known
637:alditol:NADP+ 1-oxidoreductase activity
2486:Malate dehydrogenase (decarboxylating)
1163:Aldo-keto reductase family 1 member C1
697:alcohol dehydrogenase (NADP+) activity
18:
359:
320:
315:
258:
217:
212:
7:
3038:
3036:
2581:D-lactate dehydrogenase (cytochrome)
2591:Mannitol dehydrogenase (cytochrome)
1978:The Journal of Biological Chemistry
1779:The Journal of Biological Chemistry
1664:The Journal of Biological Chemistry
1551:The Journal of Biological Chemistry
647:aldo-keto reductase (NADP) activity
3060:. You can help Knowledge (XXG) by
2685:Quinoprotein glucose dehydrogenase
2446:Glycerol-3-phosphate dehydrogenase
2359:3-hydroxybutyryl-CoA dehydrogenase
1943:Journal of Molecular Endocrinology
1200:This gene encodes a member of the
1076:
1055:
1029:
1008:
984:
965:
939:
920:
894:
875:
692:ketosteroid monooxygenase activity
577:
495:
433:
412:
14:
2441:Glucose-6-phosphate dehydrogenase
1185:that in humans is encoded by the
799:intestinal cholesterol absorption
794:bile acid and bile salt transport
3040:
3020:
2268:
2253:
2238:
2223:
2208:
1913:10.1046/j.1365-2443.2000.00310.x
1275:17β-hydroxysteroid dehydrogenase
1168:20α-hydroxysteroid dehydrogenase
588:
581:
343:
336:
330:
307:
242:
235:
229:
204:
27:
2354:3-hydroxyacyl-CoA dehydrogenase
1487:3α-Hydroxysteroid dehydrogenase
1202:aldo/keto reductase superfamily
1174:3α-hydroxysteroid dehydrogenase
749:epithelial cell differentiation
3117:Human chromosome 10 gene stubs
2680:Malate dehydrogenase (quinone)
2506:Phosphogluconate dehydrogenase
764:progesterone metabolic process
754:daunorubicin metabolic process
702:steroid dehydrogenase activity
642:indanol dehydrogenase activity
599:More reference expression data
561:More reference expression data
465:olfactory zone of nasal mucosa
1:
2144:10.1016/S0969-9961(03)00101-3
2115:10.1016/S0022-2836(03)00762-9
1792:10.1016/S0021-9258(18)82220-7
1677:10.1016/S0021-9258(17)37210-1
1564:10.1016/S0021-9258(17)40716-2
1215:20-alpha-hydroxy-progesterone
1179:dihydrodiol dehydrogenase 1/2
759:doxorubicin metabolic process
328:
227:
3107:Genes on human chromosome 10
2519:Hydroxysteroid dehydrogenase
2491:Malate dehydrogenase (NADP+)
2103:Journal of Molecular Biology
1750:10.1016/0960-0760(93)90308-J
1642:10.1016/0888-7543(95)80066-U
1599:10.1016/0960-0760(95)00019-V
1401:10.1016/0005-2728(94)90144-9
804:xenobiotic metabolic process
789:response to organophosphorus
2652:Vitamin K epoxide reductase
2421:Carbohydrate dehydrogenases
2416:Beta-Ketoacyl ACP reductase
814:protein homooligomerization
769:bile acid metabolic process
3133:
3035:
1529:gene details page in the
1510:gene details page in the
784:retinoid metabolic process
2898:Michaelis–Menten kinetics
2471:L-threonine dehydrogenase
2203:
1370:"Mouse PubMed Reference:"
1352:"Human PubMed Reference:"
1149:
1144:
1140:
1133:
1117:
1098:
1083:
1062:
1051:
1036:
1015:
1004:
991:
987:
972:
968:
959:
946:
942:
927:
923:
914:
901:
897:
882:
878:
869:
854:
847:
843:
827:
819:steroid metabolic process
779:retinal metabolic process
617:
613:
596:
580:
571:
558:
507:
498:
481:Descending thoracic aorta
445:
436:
406:
398:
394:
377:
364:
327:
306:
297:
293:
276:
263:
226:
203:
194:
190:
181:
176:
131:
128:
118:
111:
106:
71:
66:
49:
44:
39:
35:
26:
21:
2790:Diffusion-limited enzyme
2461:Isocitrate dehydrogenase
2619:L-gulonolactone oxidase
2426:Carnitine dehydrogenase
2324:alcohol oxidoreductases
2132:Neurobiology of Disease
1857:The Biochemical Journal
1814:The Biochemical Journal
1699:The Biochemical Journal
1445:J Clin Endocrinol Metab
809:cholesterol homeostasis
687:oxidoreductase activity
682:carboxylic acid binding
2511:Sorbitol dehydrogenase
2084:10.1507/endocrj.50.105
1991:10.1074/jbc.M105610200
1458:10.1210/jcem.86.2.7216
1196:Superfamily of enzymes
1111:Chr 13: 4.62 – 4.64 Mb
1104:Chr 10: 4.96 – 4.98 Mb
2883:Eadie–Hofstee diagram
2816:Allosteric regulation
2704:Choline dehydrogenase
2466:Lactate dehydrogenase
2364:Alcohol dehydrogenase
1956:10.1677/jme.0.0250221
1213:to the inactive form
728:extracellular exosome
535:primary visual cortex
322:Chromosome 13 (mouse)
220:Chromosome 10 (human)
2893:Lineweaver–Burk plot
2481:Malate dehydrogenase
2476:L-xylulose reductase
2436:DXP reductoisomerase
1523:genome location and
1504:genome location and
1237:Enzyme Name Aliases
473:left coronary artery
67:List of PDB id codes
40:Available structures
2369:Aldo-keto reductase
2050:10.3892/or.10.2.271
1531:UCSC Genome Browser
1512:UCSC Genome Browser
1230:
457:right lobe of liver
449:islet of Langerhans
3048:This article on a
2852:Enzyme superfamily
2785:Enzyme promiscuity
2021:10.3892/or.9.3.515
1229:
949:ENSMUSG00000021207
737:Biological process
711:Cellular component
625:Molecular function
170:AKR1C1 - orthologs
3069:
3068:
3008:
3007:
2717:
2716:
2697:: other acceptors
2673:/similar acceptor
2456:IMP dehydrogenase
2451:HMG-CoA reductase
2286:
2285:
2071:Endocrine Journal
1869:10.1042/bj3430487
1826:10.1042/bj3130373
1711:10.1042/bj2990545
1293:
1292:
1234:HGNC Gene Symbol
1160:
1159:
1156:
1155:
1129:
1128:
1094:
1093:
1073:
1072:
1047:
1046:
1026:
1025:
1000:
999:
981:
980:
955:
954:
936:
935:
910:
909:
891:
890:
839:
838:
672:bile acid binding
609:
608:
605:
604:
567:
566:
554:
553:
492:
491:
390:
389:
289:
288:
102:
101:
98:
97:
50:Ortholog search:
3124:
3090:
3083:
3076:
3044:
3037:
3025:
3024:
3016:
2888:Hanes–Woolf plot
2831:Enzyme activator
2826:Enzyme inhibitor
2800:Enzyme catalysis
2744:
2737:
2730:
2721:
2624:Xanthine oxidase
2411:Aldose reductase
2313:
2306:
2299:
2290:
2272:
2257:
2242:
2227:
2212:
2192:
2185:
2178:
2169:
2163:
2126:
2096:
2086:
2061:
2038:Oncology Reports
2032:
2009:Oncology Reports
2003:
1993:
1968:
1958:
1933:
1915:
1890:
1880:
1847:
1837:
1804:
1794:
1785:(14): 10448–57.
1769:
1732:
1722:
1689:
1679:
1654:
1644:
1619:
1601:
1576:
1566:
1557:(22): 15558–62.
1474:
1473:
1460:
1436:
1430:
1429:
1422:
1413:
1412:
1384:
1378:
1377:
1366:
1360:
1359:
1348:
1342:
1332:
1321:
1311:
1277:type 5; HSD17B5
1231:
1142:
1141:
1113:
1106:
1089:
1077:
1068:
1056:
1052:RefSeq (protein)
1042:
1030:
1021:
1009:
985:
966:
940:
921:
895:
876:
845:
615:
601:
592:
585:
578:
563:
539:secondary oocyte
503:
501:Top expressed in
496:
441:
439:Top expressed in
434:
413:
396:
386:
373:
362:
347:
340:
334:
323:
311:
295:
285:
272:
261:
246:
239:
233:
222:
208:
192:
186:
172:
123:
116:
93:
64:
58:
37:
36:
31:
19:
3132:
3131:
3127:
3126:
3125:
3123:
3122:
3121:
3097:
3096:
3095:
3094:
3033:
3031:
3019:
3011:
3009:
3004:
2916:Oxidoreductases
2902:
2878:Enzyme kinetics
2866:
2862:List of enzymes
2835:
2804:
2775:Catalytic triad
2753:
2748:
2718:
2713:
2689:
2661:
2633:
2629:Alcohol oxidase
2614:Glucose oxidase
2595:
2562:
2331:
2320:Oxidoreductases
2317:
2287:
2282:
2279:
2273:
2264:
2258:
2249:
2243:
2234:
2228:
2219:
2213:
2199:
2196:
2166:
2129:
2099:
2064:
2035:
2006:
1984:(45): 42091–8.
1971:
1936:
1893:
1850:
1807:
1772:
1735:
1692:
1670:(11): 8416–22.
1657:
1622:
1579:
1544:
1540:
1538:Further reading
1495:
1483:
1478:
1477:
1438:
1437:
1433:
1424:
1423:
1416:
1395:(1–2): 129–32.
1386:
1385:
1381:
1368:
1367:
1363:
1350:
1349:
1345:
1333:
1324:
1312:
1303:
1298:
1227:
1198:
1151:View/Edit Mouse
1146:View/Edit Human
1109:
1102:
1099:Location (UCSC)
1085:
1064:
1038:
1017:
930:ENSG00000187134
823:
732:
706:
677:protein binding
597:
587:
586:
559:
550:
547:muscle of thigh
545:
541:
537:
533:
529:
525:
521:
519:proximal tubule
517:
513:
499:
488:
483:
479:
477:ascending aorta
475:
471:
469:body of stomach
467:
463:
459:
455:
451:
437:
381:
368:
360:
350:
349:
348:
341:
321:
298:Gene location (
280:
267:
259:
249:
248:
247:
240:
218:
195:Gene location (
182:
132:
119:
112:
73:
51:
17:
12:
11:
5:
3130:
3128:
3120:
3119:
3114:
3109:
3099:
3098:
3093:
3092:
3085:
3078:
3070:
3067:
3066:
3045:
3030:
3029:
3006:
3005:
3003:
3002:
2989:
2976:
2963:
2950:
2937:
2924:
2910:
2908:
2904:
2903:
2901:
2900:
2895:
2890:
2885:
2880:
2874:
2872:
2868:
2867:
2865:
2864:
2859:
2854:
2849:
2843:
2841:
2840:Classification
2837:
2836:
2834:
2833:
2828:
2823:
2818:
2812:
2810:
2806:
2805:
2803:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2761:
2759:
2755:
2754:
2749:
2747:
2746:
2739:
2732:
2724:
2715:
2714:
2712:
2711:
2706:
2700:
2698:
2691:
2690:
2688:
2687:
2682:
2676:
2674:
2663:
2662:
2660:
2659:
2654:
2648:
2646:
2635:
2634:
2632:
2631:
2626:
2621:
2616:
2610:
2608:
2597:
2596:
2594:
2593:
2588:
2583:
2577:
2575:
2564:
2563:
2561:
2560:
2555:
2554:
2553:
2548:
2538:
2537:
2536:
2531:
2514:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2413:
2408:
2407:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2366:
2361:
2356:
2350:
2348:
2333:
2332:
2318:
2316:
2315:
2308:
2301:
2293:
2284:
2283:
2281:
2280:
2274:
2267:
2265:
2259:
2252:
2250:
2244:
2237:
2235:
2229:
2222:
2220:
2214:
2207:
2204:
2201:
2200:
2197:
2195:
2194:
2187:
2180:
2172:
2165:
2164:
2127:
2109:(3): 593–604.
2097:
2062:
2033:
2004:
1969:
1934:
1900:Genes to Cells
1891:
1863:(2): 487–504.
1848:
1805:
1770:
1733:
1690:
1655:
1620:
1577:
1541:
1539:
1536:
1535:
1534:
1515:
1494:
1493:External links
1491:
1490:
1489:
1482:
1479:
1476:
1475:
1431:
1414:
1379:
1361:
1343:
1322:
1300:
1299:
1297:
1294:
1291:
1290:
1287:
1279:
1278:
1271:
1263:
1262:
1259:
1251:
1250:
1247:
1239:
1238:
1235:
1226:
1223:
1197:
1194:
1165:also known as
1158:
1157:
1154:
1153:
1148:
1138:
1137:
1131:
1130:
1127:
1126:
1124:
1122:
1115:
1114:
1107:
1100:
1096:
1095:
1092:
1091:
1081:
1080:
1074:
1071:
1070:
1060:
1059:
1053:
1049:
1048:
1045:
1044:
1034:
1033:
1027:
1024:
1023:
1013:
1012:
1006:
1002:
1001:
998:
997:
989:
988:
982:
979:
978:
970:
969:
963:
957:
956:
953:
952:
944:
943:
937:
934:
933:
925:
924:
918:
912:
911:
908:
907:
899:
898:
892:
889:
888:
880:
879:
873:
867:
866:
861:
856:
852:
851:
841:
840:
837:
836:
825:
824:
822:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
740:
738:
734:
733:
731:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
628:
626:
622:
621:
611:
610:
607:
606:
603:
602:
594:
593:
575:
569:
568:
565:
564:
556:
555:
552:
551:
549:
548:
544:
540:
536:
532:
531:primary oocyte
528:
524:
520:
516:
512:
508:
505:
504:
493:
490:
489:
487:
486:
482:
478:
474:
470:
466:
462:
458:
454:
453:gastric mucosa
450:
446:
443:
442:
430:
429:
421:
410:
404:
403:
400:RNA expression
392:
391:
388:
387:
379:
375:
374:
366:
363:
358:
352:
351:
342:
335:
329:
325:
324:
319:
313:
312:
304:
303:
291:
290:
287:
286:
278:
274:
273:
265:
262:
257:
251:
250:
241:
234:
228:
224:
223:
216:
210:
209:
201:
200:
188:
187:
180:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3129:
3118:
3115:
3113:
3110:
3108:
3105:
3104:
3102:
3091:
3086:
3084:
3079:
3077:
3072:
3071:
3065:
3063:
3059:
3055:
3054:chromosome 10
3051:
3046:
3043:
3039:
3034:
3028:
3023:
3018:
3014:
3000:
2996:
2995:
2990:
2987:
2983:
2982:
2977:
2974:
2970:
2969:
2964:
2961:
2957:
2956:
2951:
2948:
2944:
2943:
2938:
2935:
2931:
2930:
2925:
2922:
2918:
2917:
2912:
2911:
2909:
2905:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2875:
2873:
2869:
2863:
2860:
2858:
2857:Enzyme family
2855:
2853:
2850:
2848:
2845:
2844:
2842:
2838:
2832:
2829:
2827:
2824:
2822:
2821:Cooperativity
2819:
2817:
2814:
2813:
2811:
2807:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2780:Oxyanion hole
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2762:
2760:
2756:
2752:
2745:
2740:
2738:
2733:
2731:
2726:
2725:
2722:
2710:
2707:
2705:
2702:
2701:
2699:
2696:
2692:
2686:
2683:
2681:
2678:
2677:
2675:
2672:
2668:
2664:
2658:
2655:
2653:
2650:
2649:
2647:
2644:
2640:
2636:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2611:
2609:
2606:
2602:
2598:
2592:
2589:
2587:
2584:
2582:
2579:
2578:
2576:
2573:
2569:
2565:
2559:
2556:
2552:
2549:
2547:
2544:
2543:
2542:
2539:
2535:
2532:
2530:
2527:
2526:
2525:
2522:
2520:
2516:
2515:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2371:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2351:
2349:
2346:
2342:
2338:
2334:
2329:
2325:
2321:
2314:
2309:
2307:
2302:
2300:
2295:
2294:
2291:
2277:
2271:
2266:
2262:
2256:
2251:
2247:
2241:
2236:
2232:
2226:
2221:
2217:
2211:
2206:
2202:
2193:
2188:
2186:
2181:
2179:
2174:
2173:
2170:
2161:
2157:
2153:
2149:
2145:
2141:
2137:
2133:
2128:
2124:
2120:
2116:
2112:
2108:
2104:
2098:
2094:
2090:
2085:
2080:
2077:(1): 105–11.
2076:
2072:
2068:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2010:
2005:
2001:
1997:
1992:
1987:
1983:
1979:
1975:
1970:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1935:
1931:
1927:
1923:
1919:
1914:
1909:
1906:(2): 111–25.
1905:
1901:
1897:
1892:
1888:
1884:
1879:
1874:
1870:
1866:
1862:
1858:
1854:
1849:
1845:
1841:
1836:
1831:
1827:
1823:
1819:
1815:
1811:
1806:
1802:
1798:
1793:
1788:
1784:
1780:
1776:
1771:
1767:
1763:
1759:
1755:
1751:
1747:
1743:
1739:
1734:
1730:
1726:
1721:
1716:
1712:
1708:
1705:(2): 545–52.
1704:
1700:
1696:
1691:
1687:
1683:
1678:
1673:
1669:
1665:
1661:
1656:
1652:
1648:
1643:
1638:
1635:(2): 588–90.
1634:
1630:
1626:
1621:
1617:
1613:
1609:
1605:
1600:
1595:
1592:(1–6): 41–6.
1591:
1587:
1583:
1578:
1574:
1570:
1565:
1560:
1556:
1552:
1548:
1543:
1542:
1537:
1532:
1528:
1527:
1522:
1521:
1516:
1513:
1509:
1508:
1503:
1502:
1497:
1496:
1492:
1488:
1485:
1484:
1480:
1472:
1468:
1464:
1459:
1454:
1450:
1446:
1442:
1435:
1432:
1427:
1421:
1419:
1415:
1410:
1406:
1402:
1398:
1394:
1390:
1383:
1380:
1375:
1371:
1365:
1362:
1357:
1353:
1347:
1344:
1340:
1336:
1331:
1329:
1327:
1323:
1319:
1315:
1310:
1308:
1306:
1302:
1295:
1288:
1286:
1285:
1281:
1280:
1276:
1272:
1270:
1269:
1265:
1264:
1260:
1258:
1257:
1253:
1252:
1248:
1246:
1245:
1241:
1240:
1236:
1233:
1232:
1224:
1222:
1220:
1216:
1212:
1207:
1203:
1195:
1193:
1191:
1188:
1184:
1180:
1176:
1175:
1170:
1169:
1164:
1152:
1147:
1143:
1139:
1136:
1132:
1125:
1123:
1120:
1116:
1112:
1108:
1105:
1101:
1097:
1090:
1088:
1082:
1078:
1075:
1069:
1067:
1061:
1057:
1054:
1050:
1043:
1041:
1035:
1031:
1028:
1022:
1020:
1014:
1010:
1007:
1005:RefSeq (mRNA)
1003:
996:
995:
990:
986:
983:
977:
976:
971:
967:
964:
962:
958:
951:
950:
945:
941:
938:
932:
931:
926:
922:
919:
917:
913:
906:
905:
900:
896:
893:
887:
886:
881:
877:
874:
872:
868:
865:
862:
860:
857:
853:
850:
846:
842:
835:
831:
826:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
741:
739:
736:
735:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
620:
619:Gene ontology
616:
612:
600:
595:
591:
584:
579:
576:
574:
570:
562:
557:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
509:
506:
502:
497:
494:
484:
480:
476:
472:
468:
464:
461:right auricle
460:
456:
452:
448:
447:
444:
440:
435:
432:
431:
428:
426:
422:
420:
419:
415:
414:
411:
409:
405:
401:
397:
393:
385:
380:
376:
372:
367:
361:13|13 A1
357:
353:
346:
339:
333:
326:
318:
314:
310:
305:
301:
296:
292:
284:
279:
275:
271:
266:
256:
252:
245:
238:
232:
225:
221:
215:
211:
207:
202:
198:
193:
189:
185:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3062:expanding it
3047:
3032:
2994:Translocases
2991:
2978:
2965:
2952:
2939:
2929:Transferases
2926:
2913:
2770:Binding site
2517:
2388:
2275:
2260:
2245:
2230:
2215:
2138:(1): 63–73.
2135:
2131:
2106:
2102:
2074:
2070:
2044:(2): 271–6.
2041:
2037:
2015:(3): 515–9.
2012:
2008:
1981:
1977:
1949:(2): 221–8.
1946:
1942:
1903:
1899:
1860:
1856:
1820:(2): 373–6.
1817:
1813:
1782:
1778:
1744:(6): 673–9.
1741:
1737:
1702:
1698:
1667:
1663:
1632:
1628:
1589:
1585:
1554:
1550:
1525:
1519:
1506:
1500:
1470:
1451:(2): 841–6.
1448:
1444:
1434:
1392:
1388:
1382:
1373:
1364:
1355:
1346:
1282:
1266:
1254:
1243:
1242:
1218:
1211:progesterone
1199:
1186:
1178:
1172:
1166:
1162:
1161:
1084:
1063:
1037:
1016:
992:
973:
947:
928:
902:
883:
863:
858:
515:human kidney
511:right kidney
423:
416:
129:External IDs
72:
2765:Active site
2645:as acceptor
2198:PDB gallery
485:gallbladder
107:Identifiers
3101:Categories
2968:Isomerases
2942:Hydrolases
2809:Regulation
2572:cytochrome
1341:, May 2017
1320:, May 2017
1296:References
543:blastocyst
427:(ortholog)
382:4,636,540
369:4,624,074
281:4,983,283
268:4,963,253
150:HomoloGene
3052:on human
2847:EC number
2643:disulfide
1087:NP_084177
1066:NP_001344
1040:NM_029901
1019:NM_001353
849:Orthologs
774:digestion
718:cytoplasm
184:1.1.1.112
178:EC number
158:GeneCards
3112:EC 1.1.1
2871:Kinetics
2795:Cofactor
2758:Activity
2607:acceptor
2574:acceptor
2551:11β-HSD2
2546:11β-HSD1
2347:acceptor
2160:21159141
2152:13678667
2123:12899831
2093:12733716
2058:12579257
2029:11956619
2000:11514561
1965:11013348
1930:25136637
1922:10672042
1887:10510318
1766:36210133
1629:Genomics
1616:11316547
1481:See also
1467:11158055
1337:–
1316:–
1135:Wikidata
828:Sources:
3027:Biology
2981:Ligases
2751:Enzymes
2671:quinone
1878:1220579
1844:8573067
1835:1216918
1801:8486699
1758:8274401
1729:8172617
1720:1138306
1686:8132567
1651:7789999
1608:7626489
1573:7515059
1409:8011662
1339:Ensembl
1318:Ensembl
1206:enzymes
961:UniProt
916:Ensembl
855:Species
834:QuickGO
723:cytosol
402:pattern
260:10p15.1
146:1924587
114:Aliases
3013:Portal
2955:Lyases
2709:L2HGDH
2695:1.1.99
2605:oxygen
2529:3β-HSD
2158:
2150:
2121:
2091:
2056:
2027:
1998:
1963:
1928:
1920:
1885:
1875:
1842:
1832:
1799:
1764:
1756:
1727:
1717:
1684:
1649:
1614:
1606:
1571:
1517:Human
1507:AKR1C1
1501:AKR1C1
1498:Human
1465:
1407:
1284:AKR1C4
1268:AKR1C3
1256:AKR1C2
1244:AKR1C1
1219:AKR1C1
1217:. The
1187:AKR1C1
1183:enzyme
1181:is an
1177:, and
1121:search
1119:PubMed
994:Q91WR5
975:Q04828
871:Entrez
573:BioGPS
527:embryo
523:morula
162:AKR1C1
154:134114
138:600449
121:AKR1C1
22:AKR1C1
3056:is a
2907:Types
2667:1.1.5
2639:1.1.4
2601:1.1.3
2568:1.1.2
2534:NSDHL
2337:1.1.1
2156:S2CID
1926:S2CID
1762:S2CID
1612:S2CID
904:77337
864:Mouse
859:Human
830:Amigo
425:Mouse
418:Human
365:Start
300:Mouse
264:Start
197:Human
3058:stub
3050:gene
2999:list
2992:EC7
2986:list
2979:EC6
2973:list
2966:EC5
2960:list
2953:EC4
2947:list
2940:EC3
2934:list
2927:EC2
2921:list
2914:EC1
2384:1B10
2345:NADP
2330:1.1)
2276:2hdj
2261:1xjb
2246:1mrq
2231:1j96
2216:1ihi
2148:PMID
2119:PMID
2089:PMID
2054:PMID
2025:PMID
1996:PMID
1961:PMID
1918:PMID
1883:PMID
1840:PMID
1797:PMID
1754:PMID
1725:PMID
1682:PMID
1647:PMID
1604:PMID
1569:PMID
1463:PMID
1405:PMID
1393:1186
1190:gene
885:1645
408:Bgee
356:Band
317:Chr.
255:Band
214:Chr.
134:OMIM
91:4YVP
87:3NTY
83:3GUG
79:3C3U
75:1MRQ
56:RCSB
53:PDBe
2558:17β
2541:11β
2404:7A2
2399:1C4
2394:1C3
2389:1C1
2379:1B1
2374:1A1
2341:NAD
2140:doi
2111:doi
2107:331
2079:doi
2046:doi
2017:doi
1986:doi
1982:276
1951:doi
1908:doi
1873:PMC
1865:doi
1861:343
1830:PMC
1822:doi
1818:313
1787:doi
1783:268
1746:doi
1715:PMC
1707:doi
1703:299
1672:doi
1668:269
1637:doi
1594:doi
1559:doi
1555:269
1453:doi
1397:doi
378:End
277:End
166:OMA
142:MGI
46:PDB
3103::
2669::
2641::
2603::
2570::
2524:3β
2339::
2328:EC
2322::
2154:.
2146:.
2136:14
2134:.
2117:.
2105:.
2087:.
2075:50
2073:.
2069:.
2052:.
2042:10
2040:.
2023:.
2011:.
1994:.
1980:.
1976:.
1959:.
1947:25
1945:.
1941:.
1924:.
1916:.
1902:.
1898:.
1881:.
1871:.
1859:.
1855:.
1838:.
1828:.
1816:.
1812:.
1795:.
1781:.
1777:.
1760:.
1752:.
1742:46
1740:.
1723:.
1713:.
1701:.
1697:.
1680:.
1666:.
1662:.
1645:.
1633:25
1631:.
1627:.
1610:.
1602:.
1590:53
1588:.
1584:.
1567:.
1553:.
1549:.
1526:C9
1520:C9
1469:.
1461:.
1449:86
1447:.
1443:.
1417:^
1403:.
1391:.
1372:.
1354:.
1325:^
1304:^
1192:.
1171:,
832:/
384:bp
371:bp
283:bp
270:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
81:,
77:,
3089:e
3082:t
3075:v
3064:.
3015::
3001:)
2997:(
2988:)
2984:(
2975:)
2971:(
2962:)
2958:(
2949:)
2945:(
2936:)
2932:(
2923:)
2919:(
2743:e
2736:t
2729:v
2521::
2343:/
2326:(
2312:e
2305:t
2298:v
2191:e
2184:t
2177:v
2162:.
2142::
2125:.
2113::
2095:.
2081::
2060:.
2048::
2031:.
2019::
2013:9
2002:.
1988::
1967:.
1953::
1932:.
1910::
1904:5
1889:.
1867::
1846:.
1824::
1803:.
1789::
1768:.
1748::
1731:.
1709::
1688:.
1674::
1653:.
1639::
1618:.
1596::
1575:.
1561::
1533:.
1514:.
1455::
1428:.
1411:.
1399::
1376:.
1358:.
302:)
199:)
168::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
