474:
451:
2960:
2945:
2990:
2975:
3005:
3020:
348:
373:
3050:
732:
1880:
725:
3035:
2915:
2930:
31:
480:
379:
6366:
6383:
1525:, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of
2399:
Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM (December 1997). "Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution".
2515:
Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship".
57:
1939:
Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, et al. (November 1998). "Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity".
2959:
2944:
2989:
2974:
2708:"Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones"
1771:
Zhang B, Zhu DW, Hu XJ, Zhou M, Shang P, Lin SX (May 2014). "Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity".
3004:
3019:
1569:, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
2300:"Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization"
3280:
2792:
Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, et al. (January 2001). "Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)".
3049:
3521:
2265:"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1"
2183:
Lin SX, Shi R, Qiu W, Azzi A, Zhu DW, Dabbagh HA, et al. (March 2006). "Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5".
3275:
3436:
487:
386:
3090:
2559:
2333:
Qin KN, New MI, Cheng KC (December 1993). "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase".
1807:
Li T, Zhang W, Lin SX (February 2020). "Steroid enzyme and receptor expression and regulations in breast tumor samples - A statistical evaluation of public data".
3330:
3514:
3034:
2968:: Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin
2953:: Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin
2222:"Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans"
3124:
2370:
Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M (August 1996). "Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+".
3365:
1185:
295:
3325:
1166:
6051:
3507:
3210:
2998:: Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin
2983:: Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin
2914:
6457:
3153:
2929:
6428:
3265:
1982:
1753:
6447:
3083:
2894:
1735:
3360:
3320:
1582:
473:
266:, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3, aldo-keto reductase family 1 member C3
3370:
3337:
1646:
2156:
3464:
3225:
3138:
1673:
3013:: Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) complexed with delta4-androstene-3,17-dione and NADP
450:
6085:
3220:
3120:
1413:
1420:
3076:
1900:"Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases"
4497:
3133:
1722:
1701:
3028:: Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404
3459:
3285:
372:
347:
6241:
2162:
1718:
3270:
54:
6356:
1697:
6044:
3298:
275:
3636:
3579:
3431:
3195:
486:
385:
4150:
6421:
6001:
4059:
3944:
3867:
3760:
3200:
2140:
human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively
479:
378:
6226:
6342:
6329:
6316:
6303:
6290:
6277:
6264:
3742:
3561:
3474:
3446:
3418:
3380:
3347:
3250:
3116:
2887:
6236:
4461:
6190:
6133:
5838:
5819:
5774:
4216:
3240:
3107:
1230:
319:
283:
6138:
3544:
3398:
3205:
1997:"The Use of Whole Exome Sequencing in a Cohort of Transgender Individuals to Identify Rare Genetic Variants"
1211:
4602:
2620:
Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, et al. (December 1999).
5880:
5800:
3290:
3103:
2110:"Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution"
6414:
6159:
6078:
5857:
4313:
3550:
3483:
3245:
3143:
2553:
1544:
361:
6231:
3058:: Crystal structure of human 17bet a-hydroxysteroid dehydrogenase type 5 in complexes with PEG and NADP
2665:"Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes"
1843:
5362:
5332:
5163:
5996:
5118:
4971:
4441:
4279:
4188:
3260:
3255:
3215:
2880:
2580:
2442:
2008:
4368:
3988:
3068:
1995:
Theisen JG, Sundaram V, Filchak MS, Chorich LP, Sullivan ME, Knight J, et al. (December 2019).
6195:
5215:
5195:
4946:
4751:
4701:
3148:
2663:
Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, et al. (February 2000).
2168:
1540:
1522:
1392:
1367:
1363:
1337:
1308:
1304:
262:
5521:
4986:
4876:
4871:
4856:
4791:
4741:
4696:
4261:
2431:"Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells"
6128:
5928:
5808:
5759:
5749:
5173:
4851:
4831:
4816:
4806:
4786:
4781:
4736:
4711:
4676:
4522:
4353:
4131:
4029:
3968:
3929:
3728:
3718:
3626:
3536:
2831:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
2817:
2694:
2651:
2541:
2468:
2429:
Mills KI, Gilkes AF, Sweeney M, Choudhry MA, Woodgate LJ, Bunce CM, et al. (November 1998).
2358:
2251:
2208:
1868:
307:
5958:
5953:
5918:
5893:
5754:
5615:
5472:
5073:
5068:
4866:
4846:
4841:
4836:
4821:
4811:
4801:
4776:
4766:
4761:
4756:
4746:
4731:
4726:
4686:
4645:
4625:
4582:
4577:
4562:
4552:
4547:
4532:
4411:
4333:
4288:
4202:
4178:
4168:
3616:
1396:
1371:
1333:
1312:
1300:
5943:
5898:
5709:
5655:
5640:
5489:
5200:
5148:
5033:
4881:
4826:
4796:
4771:
4721:
4716:
4706:
4691:
4640:
4635:
4592:
4527:
4517:
4487:
4431:
4401:
4358:
4348:
4197:
4121:
3973:
3886:
3683:
2569:"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes"
731:
6452:
5948:
5923:
5913:
5764:
5739:
5724:
5689:
5665:
5660:
5411:
5342:
5011:
4981:
4861:
4681:
4615:
4587:
4572:
4567:
4542:
4158:
4126:
4106:
4049:
3934:
3857:
3852:
3847:
3842:
3678:
3673:
3235:
3230:
2860:
2809:
2780:
2737:
2686:
2643:
2608:
2533:
2503:
2460:
2417:
2387:
2350:
2321:
2286:
2243:
2200:
2131:
2090:
2036:
1957:
1921:
1824:
1789:
1590:
255:
47:
6398:
5968:
5684:
5630:
5625:
4660:
4507:
4416:
4373:
3924:
3837:
3723:
3703:
3698:
3693:
6174:
6169:
6143:
6071:
6024:
6016:
6011:
5830:
5734:
5729:
5315:
4901:
4537:
4502:
4392:
4378:
4338:
4271:
4097:
4088:
4020:
4011:
4003:
3905:
3896:
3818:
3809:
3660:
3598:
3403:
3190:
2850:
2842:
2801:
2770:
2762:
2727:
2719:
2676:
2633:
2598:
2588:
2525:
2493:
2450:
2409:
2379:
2342:
2311:
2276:
2233:
2192:
2121:
2080:
2070:
2026:
2016:
1949:
1911:
1858:
1816:
1781:
1533:
1526:
724:
566:
497:
441:
396:
303:
4620:
4469:
325:
6221:
6205:
6118:
5872:
5804:
5714:
5389:
5367:
5337:
4034:
3408:
3393:
2059:"AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression"
1953:
1884:
1879:
1578:
541:
2584:
2446:
2012:
1883: This article incorporates text from this source, which is available under the
30:
6370:
6259:
6200:
5394:
5347:
4912:
4474:
3533:
3099:
2855:
2830:
2732:
2707:
2085:
2058:
2031:
1996:
2805:
2775:
2750:
2706:
Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, et al. (October 2000).
2638:
2621:
2455:
2430:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
924:
919:
914:
909:
904:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
6441:
6394:
6164:
6123:
5991:
5675:
5460:
5357:
5235:
5220:
5153:
5083:
2681:
2664:
2603:
2568:
2482:"Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase"
2346:
2316:
2299:
2238:
2221:
1872:
1500:
760:
2821:
2698:
2655:
2472:
2362:
2255:
2212:
287:
6113:
5531:
5448:
5374:
5352:
5305:
5240:
5210:
5190:
5185:
5108:
4996:
4421:
4383:
4251:
4078:
3914:
3799:
3606:
2545:
1559:
829:
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
559:
338:
3499:
2846:
1565:
AKR1C3 may play an important role in the development of allergic diseases such as
2829:
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000).
2622:"cDNA cloning, expression and characterization of human prostaglandin F synthase"
311:
6337:
6272:
6108:
6006:
5908:
5849:
5719:
5704:
5645:
5610:
5588:
5568:
5516:
5501:
5443:
5401:
5327:
5295:
5280:
5113:
5098:
5023:
4961:
4956:
4630:
4303:
4266:
4241:
4236:
4083:
4039:
3998:
3993:
3891:
3827:
3804:
3794:
3713:
3688:
3655:
3621:
1820:
1785:
1758:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1740:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1645:
aldo-keto reductase family 1 member C3; 3α-hydroxysteroid dehydrogenase type 2;
6365:
2573:
Proceedings of the
National Academy of Sciences of the United States of America
2021:
1661:
aldo-keto reductase family 1 member C4; 3α-hydroxysteroid dehydrogenase type 1
1633:
aldo-keto reductase family 1 member C2; 3α-hydroxysteroid dehydrogenase type 3
642:
5938:
5699:
5670:
5650:
5603:
5598:
5583:
5558:
5526:
5494:
5465:
5421:
5320:
5270:
5265:
5260:
5255:
5230:
5143:
5138:
5078:
5063:
5043:
5028:
5001:
4976:
4966:
4951:
4941:
4655:
4610:
4597:
4512:
4298:
4293:
4246:
4183:
4163:
4116:
3708:
3530:
3351:
3303:
2263:
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (1995).
2196:
458:
355:
291:
2593:
2057:
Tian Y, Zhao L, Zhang H, Liu X, Zhao L, Zhao X, et al. (February 2014).
1916:
1899:
6311:
6285:
5963:
5903:
5635:
5593:
5578:
5573:
5563:
5553:
5548:
5543:
5538:
5453:
5436:
5431:
5426:
5310:
5290:
5285:
5250:
5245:
5205:
5178:
5133:
5128:
5123:
5103:
5058:
5053:
5016:
5006:
4931:
4650:
4557:
4406:
4343:
4256:
4173:
3978:
3963:
3784:
3779:
3422:
2498:
2481:
2413:
2281:
2264:
1863:
1586:
1130:
702:
580:
525:
512:
424:
411:
299:
3308:
2864:
2813:
2784:
2741:
2690:
2647:
2612:
2537:
2298:
Khanna M, Qin KN, Klisak I, Belkin S, Sparkes RS, Cheng KC (January 1995).
2204:
2135:
2126:
2109:
2094:
2075:
2040:
1828:
1793:
2507:
2464:
2421:
2391:
2354:
2325:
2290:
2247:
1961:
1925:
1460:
1455:
5796:
5791:
5620:
5482:
5477:
5416:
5406:
5384:
5379:
5300:
5275:
5225:
5168:
5158:
5093:
5088:
5048:
4363:
3983:
3789:
1621:
aldo-keto reductase family 1 member C1; 20α-hydroxysteroid dehydrogenase
1555:
1444:
1275:
1256:
5933:
5744:
5511:
5038:
4991:
4936:
4482:
3450:
3163:
3043:: Crystal structure of prostaglandin F synathase containing bimatoprost
1242:
1197:
2766:
2723:
2529:
2383:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
6324:
6094:
5694:
4895:
3488:
3384:
3183:
3178:
3168:
3158:
1979:
1655:
1627:
1615:
1566:
1503:
1428:
1152:
6382:
1585:(CRPC). In addition, AKR1C3 overexpression may serve as a promising
2480:
Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V (February 1999).
6298:
5506:
3313:
1115:
1111:
6390:
1510:
1066:
positive regulation of reactive oxygen species metabolic process
279:
6067:
3503:
3072:
2876:
740:
2872:
2923:: Structure of prostaglandin F synthase with prostaglandin D2
3281:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
6063:
2938:: Prostaglandin F synthase complexed with NADPH and rutin
2335:
The
Journal of Steroid Biochemistry and Molecular Biology
2226:
The
Journal of Steroid Biochemistry and Molecular Biology
1809:
The
Journal of Steroid Biochemistry and Molecular Biology
1774:
The
Journal of Steroid Biochemistry and Molecular Biology
1061:
positive regulation of endothelial cell apoptotic process
946:
negative regulation of retinoic acid biosynthetic process
2751:"DNA cloning using in vitro site-specific recombination"
859:
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
784:
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
549:
6402:
1001:
regulation of retinoic acid receptor signaling pathway
6354:
714:
1076:
positive regulation of cell population proliferation
6250:
6214:
6183:
6152:
6101:
5981:
5879:
5856:
5837:
5818:
5773:
4911:
4894:
4669:
4440:
4312:
4215:
4140:
4058:
3943:
3866:
3759:
3741:
3637:
3635:
3580:
3578:
3560:
3543:
3473:
3445:
3417:
3379:
3346:
3276:
Malate dehydrogenase (oxaloacetate-decarboxylating)
3115:
1898:Khanna M, Qin KN, Wang RW, Cheng KC (August 1995).
1385:
1356:
1326:
1293:
844:
testosterone 17-beta-dehydrogenase (NADP+) activity
4918:
4060:
3945:
3868:
3761:
3437:Vitamin-K-epoxide reductase (warfarin-insensitive)
2749:Hartley JL, Temple GF, Brasch MA (November 2000).
1714:
1712:
1710:
1693:
1691:
1689:
879:prostaglandin H2 endoperoxidase reductase activity
814:dihydrotestosterone 17-beta-dehydrogenase activity
3743:
3562:
1597:Isozymes of aldo-keto reductase family 1 member C
971:positive regulation of protein kinase B signaling
496:
395:
5839:
5820:
5775:
4217:
1581:(PCa) and is associated with the development of
2108:Dufort I, Labrie F, Luu-The V (February 2001).
1016:regulation of testosterone biosynthetic process
16:Protein-coding gene in the species Homo sapiens
5881:
1985:AKR1C3 aldo-keto reductase family 1 member C3
1719:GRCm38: Ensembl release 89: ENSMUSG00000021214
6422:
6079:
5858:
4314:
3515:
3084:
2888:
1071:cellular response to prostaglandin D stimulus
8:
4442:
2558:: CS1 maint: DOI inactive as of July 2024 (
1051:cellular response to reactive oxygen species
1026:cellular response to corticosteroid stimulus
956:G protein-coupled receptor signaling pathway
774:delta4-3-oxosteroid 5beta-reductase activity
1698:GRCh38: Ensembl release 89: ENSG00000196139
1091:cellular response to prostaglandin stimulus
961:cellular response to jasmonic acid stimulus
6429:
6415:
6086:
6072:
6064:
4908:
3756:
3575:
3557:
3522:
3508:
3500:
3366:D-lactate dehydrogenase (cytochrome c-553)
3091:
3077:
3069:
2895:
2881:
2873:
1126:
874:prostaglandin D2 11-ketoreductase activity
834:testosterone dehydrogenase (NAD+) activity
756:
537:
436:
333:
65:
2854:
2774:
2731:
2680:
2637:
2602:
2592:
2497:
2454:
2315:
2280:
2237:
2125:
2084:
2074:
2030:
2020:
1975:
1973:
1971:
1915:
1862:
3211:D-malate dehydrogenase (decarboxylating)
2220:Khanna M, Qin KN, Cheng KC (June 1995).
1600:
819:phenanthrene 9,10-monooxygenase activity
6361:
2910:
2567:Griffin LD, Mellon SH (November 1999).
1685:
1481:17β-hydroxysteroid dehydrogenase type 5
789:alditol:NADP+ 1-oxidoreductase activity
4913:
3266:Malate dehydrogenase (decarboxylating)
2551:
1842:Masiutin MM, Yadav MK (3 April 2023).
1493:3α-hydroxysteroid dehydrogenase type 2
1473:Aldo-keto reductase family 1 member C3
884:alcohol dehydrogenase (NADP+) activity
20:
1954:10.1093/oxfordjournals.jbchem.a022211
1554:. It is also capable of metabolizing
501:
462:
457:
400:
359:
354:
7:
6379:
6377:
5536:Selective COX-2 inhibitors (coxibs):
3361:D-lactate dehydrogenase (cytochrome)
2794:Molecular and Cellular Endocrinology
2185:Molecular and Cellular Endocrinology
1583:castration-resistant prostate cancer
3645:Tooltip Prostaglandin D2 receptor 2
3588:Tooltip Prostaglandin D2 receptor 1
3371:Mannitol dehydrogenase (cytochrome)
1904:The Journal of Biological Chemistry
869:NADP-retinol dehydrogenase activity
854:androsterone dehydrogenase activity
809:aldo-keto reductase (NADP) activity
6401:. You can help Knowledge (XXG) by
5507:AM-404 (N-arachidonoylaminophenol)
5325:Anthranilic acids (fenamic acids):
4977:Mesalazine (5-aminosalicylic acid)
4068:Tooltip Prostaglandin EP4 receptor
3953:Tooltip Prostaglandin EP3 receptor
3876:Tooltip Prostaglandin EP2 receptor
3769:Tooltip Prostaglandin EP1 receptor
3465:Quinoprotein glucose dehydrogenase
3226:Glycerol-3-phosphate dehydrogenase
3139:3-hydroxybutyryl-CoA dehydrogenase
1521:This gene encodes a member of the
1382:
1353:
1323:
1290:
1266:
1247:
1221:
1202:
1176:
1157:
915:intracellular anatomical structure
864:ketosteroid monooxygenase activity
839:NAD-retinol dehydrogenase activity
719:
637:
575:
554:
14:
5997:γ-Linolenic acid (gamolenic acid)
5343:Meclofenamic acid (meclofenamate)
3752:Tooltip Prostaglandin E2 receptor
3571:Tooltip Prostaglandin D2 receptor
3221:Glucose-6-phosphate dehydrogenase
1506:that in humans is encoded by the
1086:testosterone biosynthetic process
981:positive regulation of cell death
799:geranylgeranyl reductase activity
779:prostaglandin-F synthase activity
6381:
6364:
6052:Leukotriene signaling modulators
5844:Tooltip Prostaglandin F synthase
5825:Tooltip Prostaglandin E synthase
5784:Tooltip Prostaglandin D synthase
4226:Tooltip Prostaglandin F receptor
3048:
3033:
3018:
3003:
2988:
2973:
2958:
2943:
2928:
2913:
2682:10.1046/j.1365-2443.2000.00310.x
1878:
1647:17β-hydroxysteroid dehydrogenase
1021:cellular response to cadmium ion
941:cellular response to calcium ion
730:
723:
485:
478:
472:
449:
384:
377:
371:
346:
29:
5363:Talinflumic acid (talinflumate)
5353:Morniflumic acid (morniflumate)
5333:Floctafenic acid (floctafenate)
5316:Tiaprofenic acid (tiaprofenate)
3134:3-hydroxyacyl-CoA dehydrogenase
1844:"Alternative androgen pathways"
1674:3α-Hydroxysteroid dehydrogenase
1523:aldo/keto reductase superfamily
1101:macromolecule metabolic process
1011:cellular response to starvation
951:prostaglandin metabolic process
6458:Human chromosome 10 gene stubs
5886:Tooltip Thromboxane A synthase
4937:Aspirin (acetylsalicylic acid)
4151:16,16-Dimethyl Prostaglandin E
3460:Malate dehydrogenase (quinone)
3286:Phosphogluconate dehydrogenase
2518:Cytogenetics and Cell Genetics
1006:progesterone metabolic process
986:daunorubicin metabolic process
889:steroid dehydrogenase activity
804:indanol dehydrogenase activity
794:retinal dehydrogenase activity
741:More reference expression data
703:More reference expression data
1:
6045:Receptor/signaling modulators
5867:Tooltip Prostacyclin synthase
5368:Tolfenamic acid (tolfenamate)
5338:Flufenamic acid (flufenamate)
5328:Etofenamic acid (etofenamate)
4384:Prostacyclin (prostaglandin I
4323:Tooltip Prostacyclin receptor
2806:10.1016/S0303-7207(00)00426-3
2639:10.1016/S0014-5793(99)01551-3
2456:10.1016/S0014-5793(98)01435-5
991:doxorubicin metabolic process
470:
369:
6448:Genes on human chromosome 10
4451:Tooltip Thromboxane receptor
3299:Hydroxysteroid dehydrogenase
3271:Malate dehydrogenase (NADP+)
2347:10.1016/0960-0760(93)90308-J
2317:10.1016/0888-7543(95)80066-U
2239:10.1016/0960-0760(95)00019-V
1036:keratinocyte differentiation
5517:Paracetamol (acetaminophen)
5348:Mefenamic acid (mefenamate)
5002:Salicylate (salicylic acid)
3432:Vitamin K epoxide reductase
3201:Carbohydrate dehydrogenases
3196:Beta-Ketoacyl ACP reductase
2847:10.1093/embo-reports/kvd058
1821:10.1016/j.jsbmb.2019.105494
1786:10.1016/j.jsbmb.2014.01.003
1577:AKR1C3 is overexpressed in
6474:
6376:
5196:Bucloxic acid (blucloxate)
5114:Indometacin (indomethacin)
2167:gene details page in the
2022:10.1038/s41598-019-53500-y
1056:farnesol catabolic process
1046:retinoid metabolic process
623:mucosa of transverse colon
6242:Michaelis–Menten kinetics
6036:
5358:Niflumic acid (niflumate)
4462:Carbocyclic thromboxane A
3251:L-threonine dehydrogenase
2908:
2197:10.1016/j.mce.2005.11.035
1754:"Mouse PubMed Reference:"
1736:"Human PubMed Reference:"
1459:
1454:
1450:
1443:
1427:
1408:
1389:
1360:
1349:
1330:
1297:
1286:
1273:
1269:
1254:
1250:
1241:
1228:
1224:
1209:
1205:
1196:
1183:
1179:
1164:
1160:
1151:
1136:
1129:
1125:
1109:
1096:retinol metabolic process
1041:retinal metabolic process
966:steroid metabolic process
759:
755:
738:
722:
713:
700:
649:
640:
587:
578:
548:
540:
536:
519:
506:
469:
448:
439:
435:
418:
405:
368:
345:
336:
332:
323:
318:
273:
270:
260:
253:
248:
73:
68:
51:
46:
41:
37:
28:
23:
6134:Diffusion-limited enzyme
5676:Menatetrenone (vitamin K
5499:Aminophenols (anilines):
3241:Isocitrate dehydrogenase
2594:10.1073/pnas.96.23.13512
1917:10.1074/jbc.270.34.20162
6002:Dihomo-γ-linolenic acid
5399:Enolic acids (oxicams):
4942:Benorilate (benorylate)
3399:L-gulonolactone oxidase
3206:Carnitine dehydrogenase
3104:alcohol oxidoreductases
2712:The Biochemical Journal
2532:(inactive 2024-07-10).
2499:10.1210/endo.140.2.6531
2414:10.1210/mend.11.13.0026
2402:Molecular Endocrinology
2114:J Clin Endocrinol Metab
1942:Journal of Biochemistry
1851:WikiJournal of Medicine
1543:, and the oxidation of
849:oxidoreductase activity
5801:selenium tetrachloride
3291:Sorbitol dehydrogenase
2127:10.1210/jcem.86.2.7216
2076:10.1186/1746-1596-9-42
1414:Chr 10: 5.04 – 5.11 Mb
1031:cyclooxygenase pathway
976:male gonad development
824:ketoreductase activity
595:pancreatic ductal cell
6227:Eadie–Hofstee diagram
6160:Allosteric regulation
5470:Aminonicotinic acids:
3484:Choline dehydrogenase
3246:Lactate dehydrogenase
3144:Alcohol dehydrogenase
2282:10.1093/dnares/2.1.37
1864:10.15347/WJM/2023.003
1421:Chr 13: 4.18 – 4.2 Mb
920:extracellular exosome
464:Chromosome 13 (mouse)
362:Chromosome 10 (human)
6237:Lineweaver–Burk plot
5119:Indometacin farnesil
4972:Magnesium salicylate
4603:Pinane thromboxane A
4364:Iloprost (ciloprost)
3984:Iloprost (ciloprost)
3790:Iloprost (ciloprost)
3261:Malate dehydrogenase
3256:L-xylulose reductase
3216:DXP reductoisomerase
2161:genome location and
2063:Diagnostic Pathology
1609:Enzyme Name Aliases
1589:for prostate cancer
996:response to nutrient
653:skin of external ear
69:List of PDB id codes
42:Available structures
4947:Carbasalate calcium
3149:Aldo-keto reductase
2585:1999PNAS...9613512G
2579:(23): 13512–13517.
2447:1998FEBSL.440..158M
2378:(33): 10702–10711.
2169:UCSC Genome Browser
2013:2019NatSR...920099T
1910:(34): 20162–20168.
1602:
1541:phenanthrenequinone
669:conjunctival fornix
619:islet of Langerhans
611:right lobe of liver
6389:This article on a
6196:Enzyme superfamily
6129:Enzyme promiscuity
5809:selenium disulfide
5441:4-Aminoquinolines:
2001:Scientific Reports
1601:
1550:to prostaglandin D
1231:ENSMUSG00000021214
934:Biological process
898:Cellular component
767:Molecular function
312:AKR1C3 - orthologs
6410:
6409:
6352:
6351:
6061:
6060:
5977:
5976:
5012:Sodium salicylate
4982:Methyl salicylate
4905:
4890:
4889:
4211:
4210:
3737:
3736:
3554:
3497:
3496:
3477:: other acceptors
3453:/similar acceptor
3236:IMP dehydrogenase
3231:HMG-CoA reductase
3066:
3065:
2767:10.1101/gr.143000
2761:(11): 1788–1795.
2724:10.1042/bj3510067
2530:10.1159/000015267
2408:(13): 1971–1984.
2384:10.1021/bi9604688
1665:
1664:
1606:HGNC Gene Symbol
1479:), also known as
1470:
1469:
1466:
1465:
1439:
1438:
1404:
1403:
1379:
1378:
1345:
1344:
1320:
1319:
1282:
1281:
1263:
1262:
1237:
1236:
1218:
1217:
1192:
1191:
1173:
1172:
1121:
1120:
751:
750:
747:
746:
709:
708:
696:
695:
634:
633:
532:
531:
431:
430:
244:
243:
240:
239:
52:Ortholog search:
6465:
6431:
6424:
6417:
6385:
6378:
6369:
6368:
6360:
6232:Hanes–Woolf plot
6175:Enzyme activator
6170:Enzyme inhibitor
6144:Enzyme catalysis
6088:
6081:
6074:
6065:
6012:Arachidonic acid
5887:
5883:
5868:
5864:
5845:
5841:
5826:
5822:
5785:
5781:
5608:Others/unsorted:
5183:Propionic acids:
5164:Sulindac sulfide
4929:Salicylic acids:
4920:
4915:
4909:
4899:
4452:
4448:
4324:
4320:
4227:
4223:
4069:
4065:
3954:
3950:
3877:
3873:
3770:
3766:
3757:
3753:
3749:
3646:
3642:
3589:
3585:
3576:
3572:
3568:
3558:
3548:
3524:
3517:
3510:
3501:
3404:Xanthine oxidase
3191:Aldose reductase
3093:
3086:
3079:
3070:
3052:
3037:
3022:
3007:
2992:
2977:
2962:
2947:
2932:
2917:
2897:
2890:
2883:
2874:
2868:
2858:
2825:
2800:(1–2): 137–149.
2788:
2778:
2745:
2735:
2702:
2684:
2659:
2641:
2616:
2606:
2596:
2563:
2557:
2549:
2524:(3–4): 241–242.
2511:
2501:
2476:
2458:
2441:(1–2): 158–162.
2425:
2395:
2366:
2329:
2319:
2294:
2284:
2259:
2241:
2216:
2143:
2142:
2129:
2105:
2099:
2098:
2088:
2078:
2054:
2048:
2047:
2034:
2024:
1992:
1986:
1977:
1966:
1965:
1936:
1930:
1929:
1919:
1895:
1889:
1882:
1876:
1866:
1848:
1839:
1833:
1832:
1804:
1798:
1797:
1768:
1762:
1761:
1750:
1744:
1743:
1732:
1726:
1716:
1705:
1695:
1649:type 5; HSD17B5
1603:
1452:
1451:
1423:
1416:
1399:
1383:
1374:
1354:
1350:RefSeq (protein)
1340:
1324:
1315:
1291:
1267:
1248:
1222:
1203:
1177:
1158:
1127:
1081:renal absorption
757:
743:
734:
727:
720:
705:
645:
643:Top expressed in
638:
583:
581:Top expressed in
576:
555:
538:
528:
515:
504:
489:
482:
476:
465:
453:
437:
427:
414:
403:
388:
381:
375:
364:
350:
334:
328:
314:
265:
258:
235:
66:
60:
39:
38:
33:
21:
6473:
6472:
6468:
6467:
6466:
6464:
6463:
6462:
6438:
6437:
6436:
6435:
6375:
6363:
6355:
6353:
6348:
6260:Oxidoreductases
6246:
6222:Enzyme kinetics
6210:
6206:List of enzymes
6179:
6148:
6119:Catalytic triad
6097:
6092:
6062:
6057:
6032:
6028:
6025:Prostaglandin H
6020:
6017:Prostaglandin G
5973:
5885:
5875:
5873:Tranylcypromine
5866:
5862:
5852:
5843:
5833:
5824:
5814:
5805:sodium selenite
5783:
5779:
5769:
5715:Rosmarinic acid
5679:
5487:Sulfonanilides:
5390:Oxyphenbutazone
4916:
4898:
4886:
4665:
4606:
4478:
4465:
4450:
4446:
4436:
4396:
4393:Prostaglandin E
4388:, epoprostenol)
4387:
4322:
4318:
4308:
4283:
4280:Prostaglandin F
4275:
4272:Prostaglandin D
4225:
4221:
4207:
4192:
4189:Prostaglandin F
4154:
4136:
4101:
4098:Prostaglandin E
4092:
4089:Prostaglandin E
4067:
4064:
4054:
4035:Ricinoleic acid
4024:
4021:Prostaglandin E
4015:
4012:Prostaglandin E
4007:
4004:Prostaglandin D
3952:
3949:
3939:
3909:
3906:Prostaglandin E
3900:
3897:Prostaglandin E
3875:
3872:
3862:
3822:
3819:Prostaglandin E
3813:
3810:Prostaglandin E
3768:
3765:
3751:
3747:
3733:
3664:
3661:Prostaglandin D
3644:
3641:
3631:
3602:
3599:Prostaglandin D
3587:
3584:
3570:
3566:
3547:
3539:
3528:
3498:
3493:
3469:
3441:
3413:
3409:Alcohol oxidase
3394:Glucose oxidase
3375:
3342:
3111:
3100:Oxidoreductases
3097:
3067:
3062:
3059:
3053:
3044:
3038:
3029:
3023:
3014:
3008:
2999:
2993:
2984:
2978:
2969:
2963:
2954:
2948:
2939:
2933:
2924:
2918:
2904:
2901:
2871:
2828:
2791:
2755:Genome Research
2748:
2718:(Pt 1): 67–77.
2705:
2662:
2619:
2566:
2550:
2514:
2479:
2428:
2398:
2369:
2332:
2297:
2262:
2219:
2182:
2178:
2176:Further reading
2152:
2147:
2146:
2107:
2106:
2102:
2056:
2055:
2051:
1994:
1993:
1989:
1978:
1969:
1938:
1937:
1933:
1897:
1896:
1892:
1846:
1841:
1840:
1836:
1806:
1805:
1801:
1770:
1769:
1765:
1752:
1751:
1747:
1734:
1733:
1729:
1717:
1708:
1696:
1687:
1682:
1670:
1599:
1579:prostate cancer
1575:
1553:
1548:
1545:prostaglandin F
1537:
1534:prostaglandin H
1530:
1527:prostaglandin D
1519:
1461:View/Edit Mouse
1456:View/Edit Human
1419:
1412:
1409:Location (UCSC)
1395:
1391:
1370:
1366:
1362:
1336:
1332:
1311:
1307:
1303:
1299:
1212:ENSG00000196139
1105:
929:
893:
739:
729:
728:
701:
692:
687:
683:
679:
677:proximal tubule
675:
671:
667:
663:
659:
655:
641:
630:
625:
621:
617:
613:
609:
607:mucosa of ileum
605:
601:
597:
593:
579:
523:
510:
502:
492:
491:
490:
483:
463:
440:Gene location (
422:
409:
401:
391:
390:
389:
382:
360:
337:Gene location (
324:
274:
261:
254:
75:
53:
17:
12:
11:
5:
6471:
6469:
6461:
6460:
6455:
6450:
6440:
6439:
6434:
6433:
6426:
6419:
6411:
6408:
6407:
6386:
6374:
6373:
6350:
6349:
6347:
6346:
6333:
6320:
6307:
6294:
6281:
6268:
6254:
6252:
6248:
6247:
6245:
6244:
6239:
6234:
6229:
6224:
6218:
6216:
6212:
6211:
6209:
6208:
6203:
6198:
6193:
6187:
6185:
6184:Classification
6181:
6180:
6178:
6177:
6172:
6167:
6162:
6156:
6154:
6150:
6149:
6147:
6146:
6141:
6136:
6131:
6126:
6121:
6116:
6111:
6105:
6103:
6099:
6098:
6093:
6091:
6090:
6083:
6076:
6068:
6059:
6058:
6056:
6055:
6048:
6041:
6037:
6034:
6033:
6031:
6030:
6026:
6022:
6018:
6014:
6009:
6007:Diacylglycerol
6004:
5999:
5994:
5985:
5983:
5979:
5978:
5975:
5974:
5972:
5971:
5966:
5961:
5956:
5951:
5946:
5941:
5936:
5931:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5890:
5888:
5877:
5876:
5871:
5869:
5860:
5854:
5853:
5848:
5846:
5835:
5834:
5829:
5827:
5816:
5815:
5813:
5812:
5794:
5788:
5786:
5777:
5771:
5770:
5768:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5682:
5677:
5673:
5668:
5663:
5658:
5653:
5648:
5643:
5638:
5633:
5628:
5623:
5618:
5613:
5601:
5596:
5591:
5586:
5581:
5576:
5571:
5566:
5561:
5556:
5551:
5546:
5541:
5529:
5524:
5519:
5514:
5509:
5504:
5492:
5480:
5475:
5463:
5451:
5446:
5434:
5429:
5424:
5419:
5414:
5409:
5404:
5395:Phenylbutazone
5392:
5387:
5382:
5377:
5365:
5360:
5355:
5350:
5345:
5340:
5335:
5330:
5318:
5313:
5308:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4925:
4923:
4906:
4892:
4891:
4888:
4887:
4885:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4704:
4699:
4694:
4689:
4684:
4679:
4673:
4671:
4667:
4666:
4664:
4663:
4658:
4653:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4604:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4510:
4505:
4500:
4491:
4490:
4485:
4480:
4476:
4472:
4467:
4463:
4455:
4453:
4444:
4438:
4437:
4435:
4434:
4425:
4424:
4419:
4414:
4409:
4404:
4399:
4394:
4390:
4385:
4381:
4376:
4371:
4369:Isocarbacyclin
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4327:
4325:
4316:
4310:
4309:
4307:
4306:
4301:
4296:
4291:
4286:
4281:
4277:
4273:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4230:
4228:
4219:
4213:
4212:
4209:
4208:
4206:
4205:
4200:
4195:
4190:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4152:
4144:
4142:
4138:
4137:
4135:
4134:
4129:
4124:
4119:
4110:
4109:
4104:
4102:(dinoprostone)
4099:
4095:
4090:
4086:
4081:
4072:
4070:
4062:
4056:
4055:
4053:
4052:
4043:
4042:
4037:
4032:
4027:
4025:(dinoprostone)
4022:
4018:
4013:
4009:
4005:
4001:
3996:
3991:
3989:Isocarbacyclin
3986:
3981:
3976:
3971:
3966:
3957:
3955:
3947:
3941:
3940:
3938:
3937:
3932:
3927:
3918:
3917:
3912:
3910:(dinoprostone)
3907:
3903:
3898:
3894:
3889:
3880:
3878:
3870:
3864:
3863:
3861:
3860:
3855:
3850:
3845:
3840:
3831:
3830:
3825:
3823:(dinoprostone)
3820:
3816:
3811:
3807:
3802:
3797:
3792:
3787:
3782:
3773:
3771:
3763:
3754:
3745:
3739:
3738:
3735:
3734:
3732:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3667:
3666:
3662:
3658:
3649:
3647:
3639:
3633:
3632:
3630:
3629:
3624:
3619:
3610:
3609:
3604:
3600:
3592:
3590:
3582:
3573:
3564:
3555:
3541:
3540:
3529:
3527:
3526:
3519:
3512:
3504:
3495:
3494:
3492:
3491:
3486:
3480:
3478:
3471:
3470:
3468:
3467:
3462:
3456:
3454:
3443:
3442:
3440:
3439:
3434:
3428:
3426:
3415:
3414:
3412:
3411:
3406:
3401:
3396:
3390:
3388:
3377:
3376:
3374:
3373:
3368:
3363:
3357:
3355:
3344:
3343:
3341:
3340:
3335:
3334:
3333:
3328:
3318:
3317:
3316:
3311:
3294:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3187:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3146:
3141:
3136:
3130:
3128:
3113:
3112:
3098:
3096:
3095:
3088:
3081:
3073:
3064:
3063:
3061:
3060:
3054:
3047:
3045:
3039:
3032:
3030:
3024:
3017:
3015:
3009:
3002:
3000:
2994:
2987:
2985:
2979:
2972:
2970:
2964:
2957:
2955:
2949:
2942:
2940:
2934:
2927:
2925:
2919:
2912:
2909:
2906:
2905:
2902:
2900:
2899:
2892:
2885:
2877:
2870:
2869:
2841:(3): 287–292.
2826:
2789:
2746:
2703:
2675:(2): 111–125.
2669:Genes to Cells
2660:
2632:(3): 335–340.
2617:
2564:
2512:
2492:(2): 568–574.
2477:
2426:
2396:
2367:
2341:(6): 673–679.
2330:
2310:(2): 588–590.
2295:
2260:
2232:(1–6): 41–46.
2217:
2191:(1–2): 38–46.
2179:
2177:
2174:
2173:
2172:
2151:
2150:External links
2148:
2145:
2144:
2100:
2049:
1987:
1967:
1948:(5): 940–946.
1931:
1890:
1834:
1799:
1763:
1745:
1727:
1706:
1684:
1683:
1681:
1678:
1677:
1676:
1669:
1666:
1663:
1662:
1659:
1651:
1650:
1643:
1635:
1634:
1631:
1623:
1622:
1619:
1611:
1610:
1607:
1598:
1595:
1574:
1571:
1551:
1546:
1535:
1528:
1518:
1515:
1468:
1467:
1464:
1463:
1458:
1448:
1447:
1441:
1440:
1437:
1436:
1434:
1432:
1425:
1424:
1417:
1410:
1406:
1405:
1402:
1401:
1387:
1386:
1380:
1377:
1376:
1358:
1357:
1351:
1347:
1346:
1343:
1342:
1328:
1327:
1321:
1318:
1317:
1295:
1294:
1288:
1284:
1283:
1280:
1279:
1271:
1270:
1264:
1261:
1260:
1252:
1251:
1245:
1239:
1238:
1235:
1234:
1226:
1225:
1219:
1216:
1215:
1207:
1206:
1200:
1194:
1193:
1190:
1189:
1181:
1180:
1174:
1171:
1170:
1162:
1161:
1155:
1149:
1148:
1143:
1138:
1134:
1133:
1123:
1122:
1119:
1118:
1107:
1106:
1104:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
937:
935:
931:
930:
928:
927:
922:
917:
912:
907:
901:
899:
895:
894:
892:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
770:
768:
764:
763:
753:
752:
749:
748:
745:
744:
736:
735:
717:
711:
710:
707:
706:
698:
697:
694:
693:
691:
690:
686:
682:
678:
674:
670:
666:
662:
658:
657:lacrimal gland
654:
650:
647:
646:
635:
632:
631:
629:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
591:jejunal mucosa
588:
585:
584:
572:
571:
563:
552:
546:
545:
542:RNA expression
534:
533:
530:
529:
521:
517:
516:
508:
505:
500:
494:
493:
484:
477:
471:
467:
466:
461:
455:
454:
446:
445:
433:
432:
429:
428:
420:
416:
415:
407:
404:
399:
393:
392:
383:
376:
370:
366:
365:
358:
352:
351:
343:
342:
330:
329:
322:
316:
315:
272:
268:
267:
259:
251:
250:
246:
245:
242:
241:
238:
237:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
6470:
6459:
6456:
6454:
6451:
6449:
6446:
6445:
6443:
6432:
6427:
6425:
6420:
6418:
6413:
6412:
6406:
6404:
6400:
6396:
6395:chromosome 10
6392:
6387:
6384:
6380:
6372:
6367:
6362:
6358:
6344:
6340:
6339:
6334:
6331:
6327:
6326:
6321:
6318:
6314:
6313:
6308:
6305:
6301:
6300:
6295:
6292:
6288:
6287:
6282:
6279:
6275:
6274:
6269:
6266:
6262:
6261:
6256:
6255:
6253:
6249:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6223:
6220:
6219:
6217:
6213:
6207:
6204:
6202:
6201:Enzyme family
6199:
6197:
6194:
6192:
6189:
6188:
6186:
6182:
6176:
6173:
6171:
6168:
6166:
6165:Cooperativity
6163:
6161:
6158:
6157:
6155:
6151:
6145:
6142:
6140:
6137:
6135:
6132:
6130:
6127:
6125:
6124:Oxyanion hole
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6106:
6104:
6100:
6096:
6089:
6084:
6082:
6077:
6075:
6070:
6069:
6066:
6054:
6053:
6049:
6047:
6046:
6042:
6039:
6038:
6035:
6029:
6023:
6021:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5992:Linoleic acid
5990:
5987:
5986:
5984:
5980:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5952:
5950:
5947:
5945:
5942:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5891:
5889:
5884:
5878:
5874:
5870:
5865:
5855:
5851:
5847:
5842:
5836:
5832:
5828:
5823:
5817:
5810:
5806:
5802:
5798:
5795:
5793:
5790:
5789:
5787:
5782:
5772:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5605:
5602:
5600:
5597:
5595:
5592:
5590:
5587:
5585:
5582:
5580:
5577:
5575:
5572:
5570:
5567:
5565:
5562:
5560:
5557:
5555:
5552:
5550:
5547:
5545:
5542:
5540:
5537:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5496:
5493:
5491:
5488:
5484:
5481:
5479:
5476:
5474:
5471:
5467:
5464:
5462:
5461:Fluproquazone
5459:
5458:Quinazolines:
5455:
5452:
5450:
5447:
5445:
5442:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5408:
5405:
5403:
5400:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5369:
5366:
5364:
5361:
5359:
5356:
5354:
5351:
5349:
5346:
5344:
5341:
5339:
5336:
5334:
5331:
5329:
5326:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5236:Flunoxaprofen
5234:
5232:
5229:
5227:
5224:
5222:
5221:Dexketoprofen
5219:
5217:
5216:Dexindoprofen
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5154:Proglumetacin
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5084:Difenpiramide
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5021:Acetic acids:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4927:
4926:
4924:
4922:
4910:
4907:
4903:
4897:
4893:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4752:Fenprostalene
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4702:Delprostenate
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4674:
4672:
4668:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4493:
4492:
4489:
4486:
4484:
4481:
4479:
4475:Thromboxane A
4473:
4471:
4468:
4466:
4460:
4457:
4456:
4454:
4449:
4439:
4433:
4430:
4427:
4426:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4397:(alprostadil)
4391:
4389:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4329:
4328:
4326:
4321:
4311:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4278:
4276:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4232:
4231:
4229:
4224:
4214:
4204:
4201:
4199:
4196:
4194:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4149:
4146:
4145:
4143:
4139:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4112:
4111:
4108:
4105:
4103:
4096:
4094:
4093:(alprostadil)
4087:
4085:
4082:
4080:
4077:
4074:
4073:
4071:
4066:
4057:
4051:
4048:
4045:
4044:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4019:
4017:
4016:(alprostadil)
4010:
4008:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3959:
3958:
3956:
3951:
3942:
3936:
3933:
3931:
3928:
3926:
3923:
3920:
3919:
3916:
3913:
3911:
3904:
3902:
3901:(alprostadil)
3895:
3893:
3890:
3888:
3885:
3882:
3881:
3879:
3874:
3865:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3833:
3832:
3829:
3826:
3824:
3817:
3815:
3814:(alprostadil)
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3775:
3774:
3772:
3767:
3758:
3755:
3750:
3740:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3669:
3668:
3665:
3659:
3657:
3654:
3651:
3650:
3648:
3643:
3634:
3628:
3625:
3623:
3620:
3618:
3615:
3612:
3611:
3608:
3605:
3603:
3597:
3594:
3593:
3591:
3586:
3577:
3574:
3569:
3559:
3556:
3552:
3546:
3542:
3538:
3535:
3532:
3525:
3520:
3518:
3513:
3511:
3506:
3505:
3502:
3490:
3487:
3485:
3482:
3481:
3479:
3476:
3472:
3466:
3463:
3461:
3458:
3457:
3455:
3452:
3448:
3444:
3438:
3435:
3433:
3430:
3429:
3427:
3424:
3420:
3416:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3391:
3389:
3386:
3382:
3378:
3372:
3369:
3367:
3364:
3362:
3359:
3358:
3356:
3353:
3349:
3345:
3339:
3336:
3332:
3329:
3327:
3324:
3323:
3322:
3319:
3315:
3312:
3310:
3307:
3306:
3305:
3302:
3300:
3296:
3295:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3151:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3131:
3129:
3126:
3122:
3118:
3114:
3109:
3105:
3101:
3094:
3089:
3087:
3082:
3080:
3075:
3074:
3071:
3057:
3051:
3046:
3042:
3036:
3031:
3027:
3021:
3016:
3012:
3006:
3001:
2997:
2991:
2986:
2982:
2976:
2971:
2967:
2961:
2956:
2952:
2946:
2941:
2937:
2931:
2926:
2922:
2916:
2911:
2907:
2898:
2893:
2891:
2886:
2884:
2879:
2878:
2875:
2866:
2862:
2857:
2852:
2848:
2844:
2840:
2836:
2832:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2790:
2786:
2782:
2777:
2772:
2768:
2764:
2760:
2756:
2752:
2747:
2743:
2739:
2734:
2729:
2725:
2721:
2717:
2713:
2709:
2704:
2700:
2696:
2692:
2688:
2683:
2678:
2674:
2670:
2666:
2661:
2657:
2653:
2649:
2645:
2640:
2635:
2631:
2627:
2623:
2618:
2614:
2610:
2605:
2600:
2595:
2590:
2586:
2582:
2578:
2574:
2570:
2565:
2561:
2555:
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2513:
2509:
2505:
2500:
2495:
2491:
2487:
2486:Endocrinology
2483:
2478:
2474:
2470:
2466:
2462:
2457:
2452:
2448:
2444:
2440:
2436:
2432:
2427:
2423:
2419:
2415:
2411:
2407:
2403:
2397:
2393:
2389:
2385:
2381:
2377:
2373:
2368:
2364:
2360:
2356:
2352:
2348:
2344:
2340:
2336:
2331:
2327:
2323:
2318:
2313:
2309:
2305:
2301:
2296:
2292:
2288:
2283:
2278:
2274:
2270:
2266:
2261:
2257:
2253:
2249:
2245:
2240:
2235:
2231:
2227:
2223:
2218:
2214:
2210:
2206:
2202:
2198:
2194:
2190:
2186:
2181:
2180:
2175:
2170:
2166:
2165:
2160:
2159:
2154:
2153:
2149:
2141:
2137:
2133:
2128:
2123:
2119:
2115:
2111:
2104:
2101:
2096:
2092:
2087:
2082:
2077:
2072:
2068:
2064:
2060:
2053:
2050:
2046:
2042:
2038:
2033:
2028:
2023:
2018:
2014:
2010:
2006:
2002:
1998:
1991:
1988:
1984:
1981:
1976:
1974:
1972:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1935:
1932:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1894:
1891:
1888:
1886:
1881:
1874:
1870:
1865:
1860:
1856:
1852:
1845:
1838:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1803:
1800:
1795:
1791:
1787:
1783:
1779:
1775:
1767:
1764:
1759:
1755:
1749:
1746:
1741:
1737:
1731:
1728:
1724:
1720:
1715:
1713:
1711:
1707:
1703:
1699:
1694:
1692:
1690:
1686:
1679:
1675:
1672:
1671:
1667:
1660:
1658:
1657:
1653:
1652:
1648:
1644:
1642:
1641:
1637:
1636:
1632:
1630:
1629:
1625:
1624:
1620:
1618:
1617:
1613:
1612:
1608:
1605:
1604:
1596:
1594:
1592:
1588:
1584:
1580:
1572:
1570:
1568:
1563:
1561:
1557:
1549:
1542:
1538:
1531:
1524:
1516:
1514:
1512:
1509:
1505:
1502:
1501:steroidogenic
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1462:
1457:
1453:
1449:
1446:
1442:
1435:
1433:
1430:
1426:
1422:
1418:
1415:
1411:
1407:
1400:
1398:
1394:
1388:
1384:
1381:
1375:
1373:
1369:
1365:
1359:
1355:
1352:
1348:
1341:
1339:
1335:
1329:
1325:
1322:
1316:
1314:
1310:
1306:
1302:
1296:
1292:
1289:
1287:RefSeq (mRNA)
1285:
1278:
1277:
1272:
1268:
1265:
1259:
1258:
1253:
1249:
1246:
1244:
1240:
1233:
1232:
1227:
1223:
1220:
1214:
1213:
1208:
1204:
1201:
1199:
1195:
1188:
1187:
1182:
1178:
1175:
1169:
1168:
1163:
1159:
1156:
1154:
1150:
1147:
1144:
1142:
1139:
1135:
1132:
1128:
1124:
1117:
1113:
1108:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
938:
936:
933:
932:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
902:
900:
897:
896:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
771:
769:
766:
765:
762:
761:Gene ontology
758:
754:
742:
737:
733:
726:
721:
718:
716:
712:
704:
699:
688:
684:
680:
676:
673:parotid gland
672:
668:
664:
660:
656:
652:
651:
648:
644:
639:
636:
626:
622:
618:
615:kidney tubule
614:
610:
606:
602:
598:
594:
590:
589:
586:
582:
577:
574:
573:
570:
568:
564:
562:
561:
557:
556:
553:
551:
547:
543:
539:
535:
527:
522:
518:
514:
509:
503:13|13 A1
499:
495:
488:
481:
475:
468:
460:
456:
452:
447:
443:
438:
434:
426:
421:
417:
413:
408:
398:
394:
387:
380:
374:
367:
363:
357:
353:
349:
344:
340:
335:
331:
327:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
269:
264:
257:
252:
247:
236:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
6403:expanding it
6388:
6338:Translocases
6335:
6322:
6309:
6296:
6283:
6273:Transferases
6270:
6257:
6114:Binding site
6050:
6043:
5988:
5607:
5535:
5532:Propacetamol
5522:Parapropamol
5498:
5486:
5469:
5457:
5449:Floctafenine
5440:
5398:
5375:Azapropazone
5372:Pyrazolones:
5371:
5324:
5306:Tarenflurbil
5241:Flurbiprofen
5211:Dexibuprofen
5191:Benoxaprofen
5186:Alminoprofen
5182:
5109:Glucametacin
5020:
4997:Salicylamide
4987:Salacetamide
4928:
4877:Trimoprostil
4872:Tiprostanide
4857:Spiriprostil
4792:Naxaprostene
4742:Esuberaprost
4697:Cobiprostone
4495:Antagonists:
4494:
4458:
4429:Antagonists:
4428:
4422:Treprostinil
4330:
4262:Fluprostenol
4252:Cloprostenol
4233:
4147:
4114:Antagonists:
4113:
4079:Lubiprostone
4075:
4047:Antagonists:
4046:
3960:
3922:Antagonists:
3921:
3915:Treprostinil
3883:
3835:Antagonists:
3834:
3800:Lubiprostone
3776:
3671:Antagonists:
3670:
3652:
3614:Antagonists:
3613:
3607:Treprostinil
3595:
3297:
3173:
3055:
3040:
3025:
3010:
2995:
2980:
2965:
2950:
2935:
2920:
2838:
2835:EMBO Reports
2834:
2797:
2793:
2758:
2754:
2715:
2711:
2672:
2668:
2629:
2626:FEBS Letters
2625:
2576:
2572:
2554:cite journal
2521:
2517:
2489:
2485:
2438:
2435:FEBS Letters
2434:
2405:
2401:
2375:
2372:Biochemistry
2371:
2338:
2334:
2307:
2303:
2275:(1): 37–43.
2272:
2269:DNA Research
2268:
2229:
2225:
2188:
2184:
2163:
2157:
2139:
2120:(2): 841–6.
2117:
2113:
2103:
2066:
2062:
2052:
2044:
2007:(1): 20099.
2004:
2000:
1990:
1945:
1941:
1934:
1907:
1903:
1893:
1877:
1854:
1850:
1837:
1812:
1808:
1802:
1777:
1773:
1766:
1757:
1748:
1739:
1730:
1654:
1639:
1638:
1626:
1614:
1576:
1564:
1560:progesterone
1520:
1507:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1471:
1393:NP_001333464
1390:
1368:NP_001240838
1364:NP_001240837
1361:
1338:NM_001346535
1331:
1309:NM_001253909
1305:NM_001253908
1298:
1274:
1255:
1229:
1210:
1184:
1165:
1145:
1140:
685:human kidney
661:right kidney
565:
558:
271:External IDs
74:
18:
6109:Active site
5989:Precursors:
5929:Nicogrelate
5909:Furegrelate
5850:Bimatoprost
5760:Trifenagrel
5750:Tiflamizole
5720:Rutecarpine
5705:Resveratrol
5646:Glimepiride
5611:Anitrazafen
5589:Robenacoxib
5569:Lumiracoxib
5502:Acetanilide
5444:Antrafenine
5402:Ampiroxicam
5296:Pranoprofen
5281:Naproxcinod
5174:Zidometacin
5099:Fenclofenac
5024:Aceclofenac
4962:Ethenzamide
4957:Dipyrocetyl
4852:Rosaprostol
4832:Posaraprost
4817:Penprostene
4807:Ornoprostil
4787:Mexiprostil
4782:Meteneprost
4737:Eptaloprost
4712:Dimoxaprost
4677:Arbaprostil
4631:Seratrodast
4523:BMS-180,291
4354:Carbacyclin
4304:Unoprostone
4284:(dinoprost)
4267:Latanoprost
4242:Bimatoprost
4237:Alfaprostol
4193:(dinoprost)
4132:ONO-AE3-208
4084:Misoprostol
4040:Sulprostone
4030:Remiprostol
3999:Misoprostol
3994:Latanoprost
3969:Carbacyclin
3930:PF-04418948
3892:Misoprostol
3828:Sulprostone
3805:Misoprostol
3795:Latanoprost
3729:Vidupiprant
3719:Timapiprant
3714:Setipiprant
3689:Fevipiprant
3656:Indometacin
3627:Vidupiprant
3622:Laropiprant
3425:as acceptor
2903:PDB gallery
1780:: 135–143.
1591:progression
627:skin of hip
599:gallbladder
249:Identifiers
6442:Categories
6312:Isomerases
6286:Hydrolases
6153:Regulation
5959:Samixogrel
5954:Rolafagrel
5939:Picotamide
5919:Midazogrel
5894:Camonagrel
5755:Timegadine
5700:Pamicogrel
5671:Licofelone
5651:Hyperforin
5616:Clobuzarit
5604:Valdecoxib
5599:Tilmacoxib
5584:Polmacoxib
5559:Etoricoxib
5527:Phenacetin
5495:Nimesulide
5473:Clonixeril
5466:Proquazone
5422:Lornoxicam
5321:Vedaprofen
5271:Miroprofen
5266:Loxoprofen
5261:Ketoprofen
5256:Indoprofen
5231:Fenoprofen
5144:Oxametacin
5139:Nabumetone
5079:Diclofenac
5074:Clometacin
5069:Cinmetacin
5064:Bumadizone
5044:Alclofenac
5029:Acemetacin
4967:Guacetisal
4952:Diflunisal
4902:inhibitors
4867:Tilsuprost
4847:Rivenprost
4842:Rioprostil
4837:Prostalene
4822:Pimilprost
4812:Oxoprostol
4802:Nocloprost
4777:Luprostiol
4767:Lanproston
4762:Froxiprost
4757:Flunoprost
4747:Etiproston
4732:Enisoprost
4727:Eganoprost
4687:Ciprostene
4656:Terutroban
4646:Sulotroban
4626:Samixogrel
4611:Ramatroban
4598:Picotamide
4583:Mipitroban
4578:Linotroban
4563:Imitrodast
4553:ICI-192605
4548:ICI-185282
4533:Domitroban
4513:Argatroban
4412:Taprostene
4334:ACT-333679
4299:Travoprost
4294:Tafluprost
4289:Sulotroban
4247:Carboprost
4203:Taprenepag
4184:Omidenepag
4179:Nocloprost
4169:Evatanepag
4164:Carboprost
4117:Grapiprant
3709:Ramatroban
3617:Asapiprant
3537:modulators
3531:Prostanoid
3352:cytochrome
1980:EntrezGene
1815:: 105494.
1725:, May 2017
1704:, May 2017
1680:References
569:(ortholog)
524:4,200,653
511:4,182,614
423:5,107,686
410:5,035,354
292:HomoloGene
6393:on human
6191:EC number
5964:Terbogrel
5944:Pirmagrel
5904:Dazoxiben
5899:Dazmegrel
5792:Retinoids
5710:Romazarit
5656:Itazigrel
5641:FR-122047
5636:Flumizole
5594:Rofecoxib
5579:Parecoxib
5574:Mavacoxib
5564:Firocoxib
5554:Deracoxib
5549:Cimicoxib
5544:Celecoxib
5539:Apricoxib
5490:Flosulide
5454:Glafenine
5437:Tenoxicam
5432:Piroxicam
5427:Meloxicam
5311:Tepoxalin
5291:Pirprofen
5286:Oxaprozin
5251:Ibuproxam
5246:Ibuprofen
5206:Carprofen
5201:Butibufen
5179:Zomepirac
5149:Oxindanac
5134:Mofezolac
5129:Lonazolac
5124:Ketorolac
5104:Fentiazac
5059:Bufexamac
5054:Bromfenac
5034:Aclofenac
5017:Triflusal
5007:Salsalate
4932:Aloxiprin
4882:Viprostol
4827:Piriprost
4797:Nileprost
4772:Limaprost
4722:Ecraprost
4717:Doxaprost
4707:Deprostil
4692:Clinprost
4651:Terbogrel
4641:SQ-29,548
4636:SQ-28,668
4593:ONO-11120
4558:Ifetroban
4528:Daltroban
4518:Bay U3405
4488:Vapiprost
4459:Agonists:
4432:RO1138452
4407:Selexipag
4402:Ralinepag
4359:Cicaprost
4349:BMY-45778
4344:Beraprost
4331:Agonists:
4257:Enprostil
4234:Agonists:
4198:Simenepag
4174:Gemeprost
4148:Agonists:
4122:GW-627368
4076:Agonists:
3979:Enprostil
3974:Cicaprost
3964:Beraprost
3961:Agonists:
3887:Butaprost
3884:Agonists:
3785:Enprostil
3780:Beraprost
3777:Agonists:
3684:Bay U3405
3653:Agonists:
3596:Agonists:
3534:signaling
3423:disulfide
2069:(1): 42.
1885:CC BY 4.0
1873:257943362
1587:biomarker
1573:Pathology
1397:NP_598827
1372:NP_003730
1334:NM_134066
1313:NM_016253
1301:NM_003739
1131:Orthologs
905:cytoplasm
320:EC number
300:GeneCards
6453:EC 1.1.1
6215:Kinetics
6139:Cofactor
6102:Activity
6040:See also
5949:Ridogrel
5924:Nafagrel
5914:Isbogrel
5797:Selenium
5765:Tropesin
5740:SC-58125
5725:Satigrel
5690:NCX-4040
5666:L-670596
5661:L-655240
5621:Curcumin
5483:Flunixin
5478:Clonixin
5417:Isoxicam
5412:Enolicam
5407:Droxicam
5385:Isopyrin
5380:Dipyrone
5301:Suprofen
5276:Naproxen
5226:Fenbufen
5169:Tolmetin
5159:Sulindac
5094:Felbinac
5089:Etodolac
5049:Bendazac
4862:Tiaprost
4682:Ataprost
4670:Unsorted
4616:Ridogrel
4588:ONO-3708
4573:L-670596
4568:L-655240
4543:GR-32191
4159:Aganepag
4141:Unsorted
4127:L-161982
4107:TCS-2510
4050:L-798106
3935:TG 4-155
3858:SC-51322
3853:SC-51089
3848:SC-19220
3843:ONO-8130
3679:AZD-1981
3674:ADC-3680
3545:Receptor
3387:acceptor
3354:acceptor
3331:11β-HSD2
3326:11β-HSD1
3127:acceptor
2865:11256614
2822:11599113
2814:11165022
2785:11076863
2742:10998348
2699:25136637
2691:10672042
2656:19812463
2648:10622721
2613:10557352
2538:10393440
2473:21355070
2363:36210133
2304:Genomics
2256:11316547
2213:19087697
2205:16480815
2136:11158055
2095:24571686
2041:31882810
1887:license.
1829:31610224
1794:24434280
1721:–
1700:–
1668:See also
1556:estrogen
1517:Function
1485:17β-HSD5
1445:Wikidata
1110:Sources:
681:gastrula
603:duodenum
326:1.3.1.20
6371:Biology
6325:Ligases
6095:Enzymes
5969:U63557A
5934:Ozagrel
5745:Tenidap
5685:NCX-466
5631:FK-3311
5626:DuP-697
5512:Bucetin
5039:Amfenac
4992:Salicin
4661:TRA-418
4508:AA-2414
4498:12-HETE
4483:U-46619
4417:TRA-418
4374:MRE-269
3925:AH-6809
3838:AH-6809
3724:TM30089
3704:QAV-680
3699:MK-7246
3694:MK-1029
3551:ligands
3451:quinone
2856:1083732
2733:1221336
2581:Bibcode
2546:5792836
2508:9927279
2465:9862446
2443:Bibcode
2422:9415401
2392:8718859
2355:8274401
2326:7789999
2291:7788527
2248:7626489
2086:3939640
2045:Table 4
2032:6934803
2009:Bibcode
1962:9792917
1926:7650035
1723:Ensembl
1702:Ensembl
1499:) is a
1497:3α-HSD2
1489:HSD17B5
1243:UniProt
1198:Ensembl
1137:Species
1116:QuickGO
925:nucleus
910:cytosol
689:decidua
544:pattern
402:10p15.1
288:2145420
256:Aliases
6357:Portal
6299:Lyases
5982:Others
5831:HQL-79
5735:SC-560
5730:SC-236
5695:NS-398
4896:Enzyme
4538:EP-045
4503:13-APA
4443:TP (TX
4379:NS-304
4339:AFP-07
3489:L2HGDH
3475:1.1.99
3385:oxygen
3309:3β-HSD
2863:
2853:
2820:
2812:
2783:
2776:310948
2773:
2740:
2730:
2697:
2689:
2654:
2646:
2611:
2601:
2544:
2536:
2506:
2471:
2463:
2420:
2390:
2361:
2353:
2324:
2289:
2254:
2246:
2211:
2203:
2164:AKR1C3
2158:AKR1C3
2155:Human
2134:
2093:
2083:
2039:
2029:
1960:
1924:
1871:
1857:: 29.
1827:
1792:
1656:AKR1C4
1640:AKR1C3
1628:AKR1C2
1616:AKR1C1
1567:asthma
1539:, and
1508:AKR1C3
1504:enzyme
1477:AKR1C3
1431:search
1429:PubMed
1276:Q8K023
1257:P42330
1186:105349
1153:Entrez
715:BioGPS
304:AKR1C3
296:128661
280:603966
263:AKR1C3
24:AKR1C3
6397:is a
6251:Types
4621:S-145
4470:I-BOP
4315:IP (I
4218:FP (F
3744:EP (E
3563:DP (D
3447:1.1.5
3419:1.1.4
3381:1.1.3
3348:1.1.2
3314:NSDHL
3117:1.1.1
2818:S2CID
2695:S2CID
2652:S2CID
2604:23979
2542:S2CID
2469:S2CID
2359:S2CID
2252:S2CID
2209:S2CID
1869:S2CID
1847:(PDF)
1491:) or
1146:Mouse
1141:Human
1112:Amigo
567:Mouse
560:Human
507:Start
442:Mouse
406:Start
339:Human
6399:stub
6391:gene
6343:list
6336:EC7
6330:list
6323:EC6
6317:list
6310:EC5
6304:list
6297:EC4
6291:list
6284:EC3
6278:list
6271:EC2
6265:list
6258:EC1
5882:TXAS
5840:PGFS
5821:PGES
4919:PTGS
3164:1B10
3125:NADP
3110:1.1)
3056:2fgb
3041:2f38
3026:1zq5
3011:1xf0
2996:1s2c
2981:1s2a
2966:1s1r
2951:1s1p
2936:1ry8
2921:1ry0
2861:PMID
2810:PMID
2781:PMID
2738:PMID
2687:PMID
2644:PMID
2609:PMID
2560:link
2534:PMID
2504:PMID
2461:PMID
2418:PMID
2388:PMID
2351:PMID
2322:PMID
2287:PMID
2244:PMID
2201:PMID
2132:PMID
2091:PMID
2037:PMID
1983:8644
1958:PMID
1922:PMID
1825:PMID
1790:PMID
1558:and
1511:gene
1167:8644
550:Bgee
498:Band
459:Chr.
397:Band
356:Chr.
276:OMIM
233:4YVV
229:4YVX
225:4ZFC
221:4XVE
217:4XVD
213:4WRH
209:4WDX
205:4WDW
201:4WDU
197:4WDT
193:4HMN
189:4H7C
185:4FAM
181:4FAL
177:4FA3
173:4DZ5
169:4DBW
165:4DBU
161:4DBS
157:3UWE
153:3UGR
149:3UG8
145:3UFY
141:3R94
137:3R8H
133:3R8G
129:3R7M
125:3R6I
121:3R58
117:3R43
113:2FGB
109:2F38
105:1ZQ5
101:1XF0
97:1S2C
93:1S2A
89:1S1R
85:1S1P
81:1RY8
77:1RY0
58:RCSB
55:PDBe
5859:PGI
5776:PGD
4914:COX
3338:17β
3321:11β
3184:7A2
3179:1C4
3174:1C3
3169:1C1
3159:1B1
3154:1A1
3121:NAD
2851:PMC
2843:doi
2802:doi
2798:171
2771:PMC
2763:doi
2728:PMC
2720:doi
2716:351
2677:doi
2634:doi
2630:462
2599:PMC
2589:doi
2526:doi
2494:doi
2490:140
2451:doi
2439:440
2410:doi
2380:doi
2343:doi
2312:doi
2277:doi
2234:doi
2193:doi
2189:248
2122:doi
2081:PMC
2071:doi
2027:PMC
2017:doi
1950:doi
1946:124
1912:doi
1908:270
1859:doi
1817:doi
1813:196
1782:doi
1778:141
665:lip
520:End
419:End
308:OMA
284:MGI
48:PDB
6444::
5807:,
5803:,
5606:;
5534:;
5497:;
5485:;
5468:;
5456:;
5439:;
5397:;
5370:;
5323:;
5181:;
5019:;
4445:A2
4282:2α
4220:2α
4191:2α
4061:EP
3946:EP
3869:EP
3762:EP
3638:DP
3581:DP
3449::
3421::
3383::
3350::
3304:3β
3119::
3108:EC
3102::
2859:.
2849:.
2837:.
2833:.
2816:.
2808:.
2796:.
2779:.
2769:.
2759:10
2757:.
2753:.
2736:.
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2693:.
2685:.
2671:.
2667:.
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1593:.
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1532:,
1513:.
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526:bp
513:bp
425:bp
412:bp
306:;
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298:;
294::
290:;
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282:;
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231:,
227:,
223:,
219:,
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