430:
407:
2531:
304:
2501:
329:
2561:
2546:
681:
2516:
2231:
to yield many cancers, and inbred families were subsequently designated by a second small letter (Aa, Ab, Ac, etc.), and thus came the Ak strain of mice. Further inbreeding was undertaken with Ak mice at the
Rockefeller Institute in 1936, leading to the designation of the AKR mouse strain. In 1977, a transforming retrovirus was isolated from the AKR mouse. This virus was named Akt-8, the "t" representing its transforming capabilities.
436:
335:
4738:
25:
2230:
The name Akt stands for Ak strain transforming. The origins of the Akt name date back to 1928, when J. Furth performed experimental studies on mice that developed spontaneous thymic lymphomas. Mice from three different stocks were studied, and the stocks were designated A, R, and S. Stock A was noted
5066:
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S,
4855:
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S,
2215:
by cocultivation with an indicator mink cell line. The transforming cellular sequences, v-akt, were cloned from a transformed mink cell clone and these sequences were used to identify Akt1 and Akt2 in a human clone library. AKT8 was isolated by
Stephen Staal in the laboratory of Wallace P. Rowe; he
99:
6241:
Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT (Jul 2000). "A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells".
5574:"IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells"
2530:
2601:
2500:
2886:
2560:
2170:
and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the
5067:
Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG (27 July 2011).
6610:
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane".
4856:
Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG (2011).
2594:
2289:
6043:
Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L (Mar 2008).
2587:
2545:
6972:
Chan TO, Rittenhouse SE, Tsichlis PN (2000). "AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation".
5721:"Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343"
2794:
443:
342:
5372:
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (Sep 1999). "NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase".
3342:
4181:
2645:
4290:
6530:"Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells"
3028:
2915:
2515:
1769:
3303:
265:
1750:
4276:
3741:
2632:
2614:
7030:
Dickson LM, Rhodes CJ (2004). "Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?".
4378:
4259:
5009:"Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma"
3965:
2834:
7187:
4823:
4029:
3004:
2480:
4805:
4285:
7152:
6789:"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase"
429:
96:
6489:"Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage"
5762:"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase"
2819:
2385:
2033:
2040:
4342:
4017:
7159:
6645:
Du K, Herzig S, Kulkarni RN, Montminy M (Jun 2003). "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver".
2539:: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS (1,3,4,5)-TETRAKISPHOPHATE
406:
4457:
3274:
3264:
2949:
6190:
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (Feb 2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex".
3956:
4841:
6701:"Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin"
6699:
Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ (Sep 2002).
4792:
4771:
4225:
3897:
3259:
3250:
2131:
2175:
receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the
2184:
328:
303:
4788:
4613:
2509:: HIGH RESOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE
6004:"p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils"
7165:
3640:
3137:
3128:
2785:
2731:
2349:
2155:
4767:
4728:
2569:: STRUCTURE OF PKBALPHA PH DOMAIN IN COMPLEX WITH A NOVEL INOSITOL HEADGROUP SURROGATE, BENZENE 1,2,3,4-TETRAKISPHOSPHATE
2828:
2172:
245:
6749:
2240:
2579:
442:
341:
3852:
3670:
3166:
2151:
5525:"Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation"
4598:
4714:
4701:
4688:
4675:
4662:
4649:
4636:
3842:
3837:
3832:
3822:
3817:
3812:
3802:
3597:
3372:
2968:
2473:
435:
334:
6528:
Bauer B, Krumböck N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, Baier G (Aug 2001).
4608:
7202:
4562:
4505:
4065:
4056:
4007:
2773:
2618:
2111:
1814:
253:
6369:
Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM (Mar 2001).
5208:"Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells"
4510:
4365:
3788:
1795:
6271:"Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status"
4950:"Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma"
5952:"Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription"
5719:
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S (Jul 2001).
2361:
2295:
39:
5423:
Romashkova JA, Makarov SS (Sep 1999). "NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling".
5296:
Zimmermann S, Moelling K (Nov 1999). "Phosphorylation and regulation of Raf by Akt (protein kinase B)".
4531:
4450:
3064:
317:
47:
6312:"Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival"
4603:
2216:
subsequently cloned v-akt and human AKT1 and AKT2 while on staff at the Johns
Hopkins Oncology Center.
5909:
Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (Feb 2003).
6800:
6654:
6441:
6382:
6323:
6199:
6056:
5773:
5626:
5432:
5381:
5020:
4961:
3631:
2466:
2162:
AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress
43:
7171:
4567:
2012:
2008:
1987:
1983:
1973:
1969:
1961:
1957:
1937:
1929:
1908:
1904:
1894:
1890:
1882:
1878:
232:
5333:"Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization"
4139:
7197:
7192:
7055:
6917:
6766:
6758:
6678:
6223:
5821:"Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest"
5554:
5456:
5405:
4930:
4500:
4242:
4196:
2166:
in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then
277:
2016:
1965:
1933:
1886:
6430:"Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor"
7133:
7098:
7047:
7018:
6989:
6960:
6909:
6869:
6828:
6741:
6722:
6670:
6627:
6592:
6551:
6510:
6469:
6410:
6351:
6292:
6251:
6215:
6172:
6128:
6084:
6025:
5981:
5932:
5911:"Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival"
5891:
5850:
5801:
5742:
5698:
5654:
5595:
5546:
5505:
5448:
5397:
5354:
5313:
5278:
5229:
5188:
5147:
5098:
5048:
4989:
4922:
4887:
3502:
3211:
2367:
2212:
225:
89:
7123:
7088:
7080:
7039:
7010:
6981:
6950:
6942:
6901:
6859:
6818:
6808:
6733:
6712:
6662:
6619:
6582:
6541:
6500:
6459:
6449:
6400:
6390:
6341:
6331:
6282:
6207:
6162:
6118:
6074:
6064:
6015:
6002:
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR (Feb 2001).
5971:
5963:
5922:
5881:
5840:
5832:
5791:
5781:
5732:
5688:
5644:
5634:
5585:
5536:
5495:
5487:
5440:
5389:
5344:
5305:
5268:
5260:
5219:
5178:
5137:
5129:
5088:
5080:
5038:
5028:
4979:
4969:
4914:
4877:
4869:
4546:
4541:
4515:
4443:
4095:
3337:
3327:
3322:
3240:
3231:
3161:
3152:
3098:
3089:
2746:
2453:
2188:
2107:
680:
522:
453:
397:
352:
34:
6107:"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family"
6892:
Hemmings BA (1997). "Akt signaling: linking membrane events to life and death decisions".
4905:
Cohen MM (2014). "Proteus syndrome review: molecular, clinical, and pathologic features".
4593:
4577:
4490:
3921:
2992:
2987:
2982:
2176:
497:
273:
6310:
Lee SB, Xuan Nguyen TL, Choi JW, Lee KH, Cho SW, Liu Z, Ye K, Bae SS, Ahn JY (Oct 2008).
1310:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
6804:
6658:
6445:
6386:
6327:
6203:
6060:
5777:
5630:
5436:
5385:
5024:
4965:
7093:
7068:
6955:
6930:
6346:
6311:
6079:
6044:
5273:
5248:
5206:
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H (Nov 1999).
5093:
5068:
4882:
4857:
4742:
4631:
4572:
2224:
2159:
2119:
6823:
6788:
6167:
6150:
5976:
5951:
5870:"Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation"
5541:
5524:
5500:
5475:
5142:
5117:
5043:
5008:
4984:
4949:
2223:
was strongly associated with
Proteus syndrome, the disease that probably affected the
1684:
1679:
1674:
1669:
1664:
1659:
1654:
1649:
1644:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
7181:
6985:
6464:
6429:
6405:
6370:
5967:
5845:
5836:
5820:
5796:
5761:
5677:"Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI"
5649:
5614:
5460:
5118:"Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt"
4934:
4536:
4495:
3045:
2977:
2167:
2147:
1440:
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
709:
7069:"Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis"
7059:
7001:
Pekarsky Y, Hallas C, Croce CM (2001). "Molecular basis of mature T-cell leukemia".
6682:
6227:
5558:
5133:
2554:: CRYSTAL STRUCTURE OF THE PH DOMAIN OF PKB ALPHA IN COMPLEX WITH A SULFATE MOLECULE
6921:
5409:
4485:
3916:
2741:
515:
294:
5309:
5264:
257:
6905:
5165:
Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB (Sep 2000).
1445:
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
281:
236:, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1
6946:
5590:
5573:
5476:"PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2"
5247:
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q (Dec 2008).
4828:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4810:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4709:
4644:
4480:
4122:
3754:
3694:
3577:
3497:
3221:
2254:
2150:. The activation is rapid and specific, and it is abrogated by mutations in the
1645:
positive regulation of cyclin-dependent protein serine/threonine kinase activity
1190:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
7043:
4737:
598:
4210:
2684:
2301:
2204:
2135:
2115:
1015:
cellular response to granulocyte macrophage colony-stimulating factor stimulus
414:
311:
261:
7014:
5786:
5224:
5207:
6813:
6737:
6666:
6336:
6211:
6069:
5491:
5033:
4683:
4657:
3171:
2391:
2163:
1714:
658:
536:
481:
468:
380:
367:
269:
7137:
7102:
7051:
7022:
6993:
6964:
6873:
6864:
6847:
6832:
6745:
6726:
6717:
6700:
6674:
6631:
6596:
6587:
6570:
6555:
6546:
6529:
6514:
6505:
6488:
6473:
6454:
6414:
6395:
6355:
6296:
6287:
6270:
6255:
6219:
6176:
6132:
6123:
6106:
6088:
6029:
6020:
6003:
5985:
5936:
5927:
5910:
5895:
5886:
5869:
5854:
5746:
5737:
5720:
5702:
5693:
5676:
5658:
5639:
5599:
5550:
5509:
5452:
5401:
5358:
5349:
5332:
5317:
5282:
5233:
5192:
5183:
5166:
5151:
5102:
4974:
4926:
4891:
4858:"A mosaic activating mutation in AKT1 associated with the Proteus syndrome"
7084:
6913:
6755:. If this is an intentional citation to a retracted paper, please replace
6045:"Akt and CHIP coregulate tau degradation through coordinated interactions"
5805:
5084:
5052:
4873:
2080:
2075:
1000:
negative regulation of long-chain fatty acid import across plasma membrane
7128:
7111:
4993:
3527:
3422:
3417:
3412:
2331:
2200:
2180:
2143:
2134:
AKT1 is catalytically inactive in serum-starved primary and immortalized
2064:
1859:
1840:
1480:
positive regulation of epidermal growth factor receptor signaling pathway
1275:
negative regulation of protein kinase activity by protein phosphorylation
1040:
glycogen cell differentiation involved in embryonic placenta development
5868:
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ (Jan 2002).
4186:
4164:
4159:
4149:
4144:
3946:
3941:
3936:
3931:
3926:
3911:
3906:
3557:
3522:
2761:
2756:
2751:
2313:
2208:
1826:
1781:
1660:
cellular response to oxidised low-density lipoprotein particle stimulus
6623:
5760:
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S (Sep 1998).
5069:"A Mosaic Activating Mutation in Associated with the Proteus Syndrome"
4918:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
5523:
Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S (Feb 2003).
4696:
4466:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4337:
4332:
4327:
4322:
4317:
4300:
4295:
4169:
4154:
4105:
4100:
4085:
4080:
4075:
4070:
4044:
4039:
4034:
4022:
4000:
3995:
3887:
3862:
3537:
3362:
3357:
3352:
3347:
3332:
3176:
3113:
3108:
3103:
3079:
2905:
2900:
2874:
2869:
2864:
2854:
2849:
2839:
2679:
2610:
2325:
2319:
2307:
2272:
2096:
2048:
1736:
6371:"Akt phosphorylates and regulates the orphan nuclear receptor Nur77"
2122:. It is commonly referred to as PKB, or by both names as "Akt/PKB".
6848:"Identification of 14-3-3zeta as a protein kinase B/Akt substrate"
5444:
5393:
4670:
4312:
4305:
4215:
4112:
4012:
3990:
3985:
3980:
3975:
3970:
3882:
3877:
3872:
3867:
3857:
3827:
3807:
3684:
3679:
3660:
3655:
3645:
3621:
3616:
3611:
3587:
3582:
3572:
3567:
3562:
3552:
3532:
3517:
3512:
3507:
3487:
3482:
3472:
3467:
3462:
3457:
3452:
3442:
3437:
3432:
3427:
3407:
3402:
3397:
3392:
3387:
3382:
3367:
3317:
3312:
3206:
3201:
3196:
3191:
3186:
3181:
3142:
3074:
3069:
3018:
3013:
2939:
2934:
2929:
2895:
2887:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2689:
2674:
2669:
2664:
2659:
2654:
2524:: CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PKB ALPHA
2421:
2403:
2397:
2379:
2343:
2337:
2266:
2260:
2248:
5167:"Negative regulation of the serine/threonine kinase B-Raf by Akt"
4842:"Entrez Gene: AKT1 v-akt murine thymoma viral oncogene homolog 1"
1699:
1695:
4205:
4132:
4127:
4117:
4090:
3847:
3797:
3778:
3773:
3768:
3763:
3718:
3713:
3708:
3703:
3650:
3606:
3547:
3542:
3492:
3477:
3447:
3377:
3293:
3288:
3283:
3216:
3118:
3059:
3054:
2958:
2924:
2809:
2804:
2799:
2768:
2736:
2724:
2719:
2704:
2699:
2447:
2441:
2415:
2409:
2373:
2355:
2283:
2278:
2139:
2103:
1430:
cellular response to vascular endothelial growth factor stimulus
1245:
positive regulation of DNA-binding transcription factor activity
1230:
negative regulation of release of cytochrome c from mitochondria
249:
4439:
4363:
3739:
2630:
2583:
2462:
1655:
negative regulation of protein serine/threonine kinase activity
4174:
2709:
2694:
2458:
2435:
1585:
positive regulation of protein localization to plasma membrane
1020:
positive regulation of blood vessel endothelial cell migration
689:
18:
6846:
Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR (Jun 2002).
6571:"The activity of the plexin-A1 receptor is regulated by Rac"
5950:
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (Aug 2002).
2199:
AKT (now also called AKT1) was originally identified as the
1665:
positive regulation of G1/S transition of mitotic cell cycle
6787:
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (Sep 2004).
1675:
positive regulation of protein localization to cell surface
6149:
Laine J, KĂĽnstle G, Obata T, Sha M, Noguchi M (Aug 2000).
4435:
6487:
Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J (Nov 2000).
2154:
of AKT1. It was shown that the activation occurs through
1460:
positive regulation of transcription by RNA polymerase II
6931:"The PI3K-PDK1 connection: more than just a road to PKB"
5819:
Paramio JM, Segrelles C, Ruiz S, Jorcano JL (Nov 2001).
1345:
positive regulation of nitric oxide biosynthetic process
505:
6269:
Cheng SW, Fryer LG, Carling D, Shepherd PR (Apr 2004).
5615:"Modulation of Akt kinase activity by binding to Hsp90"
1570:
positive regulation of mitochondrial membrane potential
1500:
regulation of signal transduction by p53 class mediator
1495:
positive regulation of smooth muscle cell proliferation
1395:
establishment of protein localization to mitochondrion
1305:
positive regulation of protein localization to nucleus
1115:
positive regulation of peptidyl-serine phosphorylation
6151:"The protooncogene TCL1 is an Akt kinase coactivator"
4726:
2093:
RAC(Rho family)-alpha serine/threonine-protein kinase
1375:
cellular response to epidermal growth factor stimulus
1335:
positive regulation of endothelial cell proliferation
1130:
positive regulation of nitric-oxide synthase activity
1080:
insulin-like growth factor receptor signaling pathway
970:
positive regulation of endodeoxyribonuclease activity
670:
1565:
positive regulation of cell population proliferation
1090:
positive regulation of glycogen biosynthetic process
6105:Laine J, KĂĽnstle G, Obata T, Noguchi M (Feb 2002).
5331:Fujita N, Sato S, Katayama K, Tsuruo T (Aug 2002).
4622:
4586:
4555:
4524:
4473:
4377:
4275:
4258:
4241:
4224:
4195:
4055:
3955:
3896:
3787:
3753:
3693:
3669:
3630:
3596:
3302:
3273:
3249:
3230:
3151:
3127:
3088:
3044:
3027:
3003:
2967:
2948:
2914:
2885:
2818:
2784:
2644:
2001:
1956:
1922:
1877:
1670:
negative regulation of leukocyte cell-cell adhesion
1545:
positive regulation of transcription, DNA-templated
4784:
4782:
4780:
4763:
4761:
4759:
2444:– the gene for the second member of the AKT family
1560:epidermal growth factor receptor signaling pathway
7110:Shinohara M, Chung YJ, Saji M, Ringel MD (2007).
2450:– the gene for the third member of the AKT family
1620:cell migration involved in sprouting angiogenesis
1605:negative regulation of protein kinase B signaling
935:positive regulation of lipid biosynthetic process
925:cellular response to nerve growth factor stimulus
778:protein serine/threonine/tyrosine kinase activity
452:
351:
5249:"Negative Regulation of AKT Activation by BRCA1"
1265:maintenance of protein location in mitochondrion
1250:positive regulation of glucose metabolic process
1085:positive regulation of protein metabolic process
1005:negative regulation of fatty acid beta-oxidation
758:phosphatidylinositol-3,4,5-trisphosphate binding
6782:
6780:
6694:
6692:
6144:
6142:
6100:
6098:
5997:
5995:
5714:
5712:
5670:
5668:
1555:positive regulation of I-kappaB phosphorylation
1185:positive regulation of fat cell differentiation
965:response to insulin-like growth factor stimulus
16:Protein-coding gene in the species Homo sapiens
7112:"AKT in thyroid tumorigenesis and progression"
4789:GRCm38: Ensembl release 89: ENSMUSG00000001729
1650:negative regulation of Notch signaling pathway
1215:negative regulation of protein kinase activity
930:positive regulation of protein phosphorylation
4451:
2646:Non-specific serine/threonine protein kinases
2595:
2474:
2207:, AKT8. AKT8 was isolated from a spontaneous
1635:negative regulation of protein ubiquitination
1470:negative regulation of endopeptidase activity
1370:mammary gland epithelial cell differentiation
1300:lipopolysaccharide-mediated signaling pathway
1120:cellular response to prostaglandin E stimulus
798:phosphatidylinositol-3,4-bisphosphate binding
8:
6428:Lin HK, Yeh S, Kang HY, Chang C (Jun 2001).
1535:cellular response to reactive oxygen species
1360:regulation of nitric-oxide synthase activity
1325:peripheral nervous system myelin maintenance
1240:cellular response to organic cyclic compound
1200:G protein-coupled receptor signaling pathway
1170:cellular response to decreased oxygen levels
5572:Kawauchi K, Ihjima K, Yamada O (May 2005).
4948:Staal SP, Hartley JW, Rowe WP (July 1977).
4768:GRCh38: Ensembl release 89: ENSG00000142208
1680:negative regulation of lymphocyte migration
1450:positive regulation of fibroblast migration
1410:positive regulation of sodium ion transport
1350:cellular response to growth factor stimulus
1100:labyrinthine layer blood vessel development
1035:regulation of glycogen biosynthetic process
940:regulation of neuron projection development
7155:- Learn more about AKT1 Reference Controls
6769:|...|intentional=yes}}
6569:Turner LJ, Nicholls S, Hall A (Aug 2004).
4458:
4444:
4436:
4374:
4360:
3750:
3736:
3029:Goodpasture-antigen-binding protein kinase
2641:
2627:
2602:
2588:
2580:
2481:
2467:
2459:
1953:
1874:
1710:
1615:cellular response to tumor necrosis factor
705:
493:
392:
289:
107:
7127:
7092:
6954:
6863:
6822:
6812:
6716:
6586:
6545:
6504:
6463:
6453:
6404:
6394:
6345:
6335:
6286:
6166:
6122:
6078:
6068:
6019:
5975:
5926:
5885:
5844:
5795:
5785:
5736:
5692:
5648:
5638:
5589:
5540:
5499:
5348:
5272:
5223:
5182:
5141:
5092:
5042:
5032:
4983:
4973:
4881:
3742:Serine/threonine-specific protein kinases
2916:(isocitrate dehydrogenase (NADP+)) kinase
2633:Serine/threonine-specific protein kinases
2615:Serine/threonine-specific protein kinases
1485:interleukin-18-mediated signaling pathway
4277:Receptor protein serine/threonine kinase
1580:negative regulation of apoptotic process
1420:positive regulation of apoptotic process
995:cellular response to mechanical stimulus
975:cellular response to DNA damage stimulus
945:activation-induced cell death of T cells
808:protein serine/threonine kinase activity
733:nitric-oxide synthase regulator activity
5613:Sato S, Fujita N, Tsuruo T (Sep 2000).
4755:
4733:
4260:Low-density-lipoprotein receptor kinase
2496:
1595:activation of protein kinase B activity
1530:phosphatidylinositol 3-kinase signaling
1150:positive regulation of vasoconstriction
32:It has been suggested that portions of
1640:negative regulation of protein binding
1625:positive regulation of gene expression
1110:negative regulation of gene expression
67:
3005:Fas-activated serine/threonine kinase
1505:negative regulation of macroautophagy
1165:cellular response to insulin stimulus
920:positive regulation of glucose import
457:
418:
413:
356:
315:
310:
7:
6929:Vanhaesebroeck B, Alessi DR (2000).
4286:Bone morphogenetic protein receptors
1435:striated muscle cell differentiation
633:endothelial cell of lymphatic vessel
2820:Dephospho-(reductase kinase) kinase
1630:cytokine-mediated signaling pathway
1525:I-kappaB kinase/NF-kappaB signaling
1520:positive regulation of organ growth
1195:negative regulation of neuron death
955:regulation of cell cycle checkpoint
3275:G-protein coupled receptor kinases
1998:
1919:
1850:
1831:
1805:
1786:
1760:
1741:
1490:insulin receptor signaling pathway
1385:negative regulation of JNK cascade
1380:multicellular organism development
1295:peptidyl-threonine phosphorylation
1125:positive regulation of cell growth
1075:negative regulation of proteolysis
980:regulation of protein localization
675:
593:
531:
510:
14:
7032:Am. J. Physiol. Endocrinol. Metab
5675:Barry FA, Gibbins JM (Apr 2002).
3265:Beta adrenergic receptor kinase-2
2950:(tyrosine 3-monooxygenase) kinase
2099:that in humans is encoded by the
1610:excitatory postsynaptic potential
1330:nitric oxide biosynthetic process
1315:intracellular signal transduction
813:protein homodimerization activity
723:GTPase activating protein binding
6986:10.1146/annurev.biochem.68.1.965
5968:10.1128/mcb.22.16.5962-5974.2002
5837:10.1128/MCB.21.21.7449-7459.2001
5116:Remy I, Michnick SW (Feb 2004).
4736:
3957:Mitogen-activated protein kinase
2559:
2544:
2529:
2514:
2499:
1550:cellular response to cadmium ion
1060:negative regulation of cell size
1050:negative regulation of autophagy
679:
441:
434:
428:
405:
340:
333:
327:
302:
23:
5134:10.1128/mcb.24.4.1493-1504.2004
5073:New England Journal of Medicine
4343:Anti-MĂĽllerian hormone receptor
4226:(acetyl-CoA carboxylase) kinase
3898:(RNA-polymerase)-subunit kinase
3260:Beta adrenergic receptor kinase
3251:Beta adrenergic receptor kinase
2132:serine-threonine protein kinase
1575:regulation of apoptotic process
1405:peptidyl-serine phosphorylation
1400:apoptotic mitochondrial changes
5474:Lynch DK, Daly RJ (Jan 2002).
3966:Extracellular signal-regulated
2185:single-nucleotide polymorphism
1590:carbohydrate metabolic process
1260:response to fluid shear stress
1065:endocrine pancreas development
748:protein phosphatase 2A binding
690:More reference expression data
659:More reference expression data
1:
6168:10.1016/S1097-2765(00)00039-3
5542:10.1016/s0014-5793(03)00058-9
5310:10.1126/science.286.5445.1741
5265:10.1158/0008-5472.CAN-08-3009
4030:P38 mitogen-activated protein
3129:cGMP-dependent protein kinase
3090:cAMP-dependent protein kinase
2786:Pyruvate dehydrogenase kinase
2732:Ataxia telangiectasia mutated
2156:phosphatidylinositol 3-kinase
2106:. This enzyme belongs to the
1390:glycogen biosynthetic process
1135:maternal placenta development
1045:cell population proliferation
960:response to organic substance
583:muscle layer of sigmoid colon
426:
325:
7188:Genes on human chromosome 14
6906:10.1126/science.275.5300.628
6793:Proc. Natl. Acad. Sci. U.S.A
6434:Proc. Natl. Acad. Sci. U.S.A
6375:Proc. Natl. Acad. Sci. U.S.A
6316:Proc. Natl. Acad. Sci. U.S.A
6049:Proc. Natl. Acad. Sci. U.S.A
5766:Proc. Natl. Acad. Sci. U.S.A
5619:Proc. Natl. Acad. Sci. U.S.A
5013:Proc. Natl. Acad. Sci. U.S.A
4954:Proc. Natl. Acad. Sci. U.S.A
2829:AMP-activated protein kinase
2438:– the AKT family of proteins
1320:regulation of cell migration
1235:execution phase of apoptosis
1225:regulation of mRNA stability
1210:cellular response to peptide
1155:hyaluronan metabolic process
1105:response to oxidative stress
1055:cellular response to hypoxia
1010:cell projection organization
5591:10.4049/jimmunol.174.9.5261
3744:(EC 2.7.11.21-EC 2.7.11.30)
1685:protein import into nucleus
1175:protein autophosphorylation
547:stromal cell of endometrium
7219:
7170:gene details page in the
7044:10.1152/ajpendo.00031.2004
3671:Elongation factor 2 kinase
2635:(EC 2.7.11.1-EC 2.7.11.20)
2152:pleckstrin homology domain
2041:Chr 12: 112.62 – 112.64 Mb
1600:protein kinase B signaling
1415:response to growth hormone
1280:osteoblast differentiation
1255:nervous system development
1030:glycogen metabolic process
899:protein-containing complex
6947:10.1042/0264-6021:3460561
4824:"Mouse PubMed Reference:"
4806:"Human PubMed Reference:"
4614:Michaelis–Menten kinetics
4373:
4359:
4066:MAP kinase kinase kinases
3749:
3735:
3598:Myosin light-chain kinase
3304:Ca2+/calmodulin-dependent
2969:Myosin-heavy-chain kinase
2640:
2626:
2494:
2079:
2074:
2070:
2063:
2047:
2034:Chr 14: 104.77 – 104.8 Mb
2028:
2005:
1980:
1949:
1926:
1901:
1870:
1857:
1853:
1838:
1834:
1825:
1812:
1808:
1793:
1789:
1780:
1767:
1763:
1748:
1744:
1735:
1720:
1713:
1709:
1693:
1455:regulation of translation
1270:protein catabolic process
1140:regulation of myelination
1025:glucose metabolic process
803:identical protein binding
708:
704:
687:
678:
669:
656:
605:
596:
543:
534:
504:
496:
492:
475:
462:
425:
404:
395:
391:
374:
361:
324:
301:
292:
288:
243:
240:
230:
223:
218:
115:
110:
93:
88:
83:
79:
75:
70:
7015:10.1001/jama.286.18.2308
5787:10.1073/pnas.95.19.11211
5225:10.1074/jbc.274.45.32274
4506:Diffusion-limited enzyme
4366:Dual-specificity kinases
2112:serine/threonine kinases
869:microtubule cytoskeleton
788:protein kinase C binding
6814:10.1073/pnas.0405659101
6738:10.1074/jbc.A116.205838
6667:10.1126/science.1079817
6337:10.1073/pnas.0807668105
6212:10.1126/science.1106148
6070:10.1073/pnas.0709180105
5034:10.1073/pnas.84.14.5034
3789:Cyclin-dependent kinase
2239:AKT1 has been shown to
2219:In 2011, a mutation in
2211:cell line derived from
2138:. AKT1 and the related
1540:NIK/NF-kappaB signaling
1160:spinal cord development
990:protein phosphorylation
743:protein kinase activity
6865:10.1074/jbc.M203167200
6718:10.1074/jbc.M205838200
6588:10.1074/jbc.M402943200
6547:10.1074/jbc.M103098200
6506:10.1074/jbc.M001753200
6455:10.1073/pnas.121173298
6396:10.1073/pnas.051003198
6288:10.1074/jbc.C300534200
6124:10.1074/jbc.M107069200
6021:10.1074/jbc.M005953200
5928:10.1074/jbc.M211598200
5887:10.1074/jbc.M110299200
5738:10.1074/jbc.M102940200
5694:10.1074/jbc.M200482200
5640:10.1073/pnas.170276797
5350:10.1074/jbc.M203668200
5184:10.1074/jbc.M004371200
5007:Staal SP (July 1987).
4975:10.1073/pnas.74.7.3065
2118:(Src homology 2-like)
1145:protein ubiquitination
1070:carbohydrate transport
783:protein kinase binding
768:14-3-3 protein binding
7085:10.1083/jcb.200408161
6761:|...}}
6732:(Retracted, see
5492:10.1093/emboj/21.1.72
5085:10.1056/NEJMoa1104017
4874:10.1056/NEJMoa1104017
4599:Eadie–Hofstee diagram
4532:Allosteric regulation
1180:inflammatory response
915:germ cell development
641:stroma of bone marrow
571:right coronary artery
459:12 F1|12 61.2 cM
420:Chromosome 12 (mouse)
318:Chromosome 14 (human)
7164:genome location and
7129:10.1210/en.2006-0937
4609:Lineweaver–Burk plot
3632:Phosphorylase kinase
2203:in the transforming
2187:in this gene causes
2158:. In the developing
1355:T cell costimulation
1340:protein biosynthesis
1205:cell differentiation
763:transferase activity
563:right adrenal cortex
111:List of PDB id codes
84:Available structures
46:into this article. (
7172:UCSC Genome Browser
7067:Manning BD (2004).
6805:2004PNAS..10113489R
6659:2003Sci...300.1574D
6446:2001PNAS...98.7200L
6387:2001PNAS...98.3690P
6328:2008PNAS..10516584L
6204:2005Sci...307.1098S
6061:2008PNAS..105.3622D
5778:1998PNAS...9511211D
5631:2000PNAS...9710832S
5437:1999Natur.401...86R
5386:1999Natur.401...82N
5025:1987PNAS...84.5034S
4966:1977PNAS...74.3065S
1465:signal transduction
1290:response to hormone
1095:glucose homeostasis
985:platelet activation
637:submandibular gland
559:right adrenal gland
555:left adrenal cortex
551:ganglionic eminence
6974:Annu. Rev. Biochem
6198:(5712): 1098–101.
4568:Enzyme superfamily
4501:Enzyme promiscuity
4243:Tropomyosin kinase
4197:Tau-protein kinase
1815:ENSMUSG00000001729
908:Biological process
864:ciliary basal body
849:cell-cell junction
827:Cellular component
818:calmodulin binding
793:nucleotide binding
716:Molecular function
6624:10.1021/bi016068o
6581:(32): 33199–205.
4919:10.1111/cge.12266
4724:
4723:
4433:
4432:
4429:
4428:
4425:
4424:
4355:
4354:
4351:
4350:
3731:
3730:
3727:
3726:
3212:Protein kinase N1
3167:Protein kinase Cζ
2577:
2576:
2142:are activated by
2090:
2089:
2086:
2085:
2059:
2058:
2024:
2023:
1995:
1994:
1945:
1944:
1916:
1915:
1866:
1865:
1847:
1846:
1821:
1820:
1802:
1801:
1776:
1775:
1757:
1756:
1705:
1704:
1475:apoptotic process
700:
699:
696:
695:
665:
664:
652:
651:
590:
589:
488:
487:
387:
386:
214:
213:
210:
209:
94:Ortholog search:
64:
63:
7210:
7141:
7131:
7106:
7096:
7063:
7026:
6997:
6968:
6958:
6925:
6900:(5300): 628–30.
6878:
6877:
6867:
6858:(24): 21639–42.
6843:
6837:
6836:
6826:
6816:
6799:(37): 13489–94.
6784:
6775:
6774:
6772:
6770:
6762:
6751:Retraction Watch
6730:
6720:
6711:(38): 35364–70.
6696:
6687:
6686:
6653:(5625): 1574–7.
6642:
6636:
6635:
6607:
6601:
6600:
6590:
6566:
6560:
6559:
6549:
6540:(34): 31627–34.
6525:
6519:
6518:
6508:
6484:
6478:
6477:
6467:
6457:
6425:
6419:
6418:
6408:
6398:
6366:
6360:
6359:
6349:
6339:
6307:
6301:
6300:
6290:
6281:(16): 15719–22.
6266:
6260:
6259:
6238:
6232:
6231:
6187:
6181:
6180:
6170:
6146:
6137:
6136:
6126:
6102:
6093:
6092:
6082:
6072:
6040:
6034:
6033:
6023:
5999:
5990:
5989:
5979:
5947:
5941:
5940:
5930:
5906:
5900:
5899:
5889:
5865:
5859:
5858:
5848:
5816:
5810:
5809:
5799:
5789:
5757:
5751:
5750:
5740:
5716:
5707:
5706:
5696:
5672:
5663:
5662:
5652:
5642:
5610:
5604:
5603:
5593:
5569:
5563:
5562:
5544:
5520:
5514:
5513:
5503:
5471:
5465:
5464:
5420:
5414:
5413:
5369:
5363:
5362:
5352:
5343:(32): 28706–13.
5328:
5322:
5321:
5304:(5445): 1741–4.
5293:
5287:
5286:
5276:
5244:
5238:
5237:
5227:
5203:
5197:
5196:
5186:
5162:
5156:
5155:
5145:
5113:
5107:
5106:
5096:
5063:
5057:
5056:
5046:
5036:
5004:
4998:
4997:
4987:
4977:
4945:
4939:
4938:
4902:
4896:
4895:
4885:
4852:
4846:
4845:
4838:
4832:
4831:
4820:
4814:
4813:
4802:
4796:
4786:
4775:
4765:
4741:
4740:
4732:
4604:Hanes–Woolf plot
4547:Enzyme activator
4542:Enzyme inhibitor
4516:Enzyme catalysis
4460:
4453:
4446:
4437:
4375:
4361:
4008:C-Jun N-terminal
3751:
3737:
3241:Rhodopsin kinase
3232:Rhodopsin kinase
3162:Protein kinase C
3153:Protein kinase C
3138:Protein kinase G
3099:Protein kinase A
2710:Protein kinase B
2642:
2628:
2604:
2597:
2590:
2581:
2563:
2548:
2533:
2518:
2503:
2483:
2476:
2469:
2460:
2454:Proteus syndrome
2189:Proteus syndrome
2072:
2071:
2043:
2036:
2019:
1999:
1990:
1954:
1950:RefSeq (protein)
1940:
1920:
1911:
1875:
1851:
1832:
1806:
1787:
1761:
1742:
1711:
1425:response to food
1285:response to UV-A
950:response to heat
706:
692:
683:
676:
661:
629:efferent ductule
609:ventricular zone
601:
599:Top expressed in
594:
567:ventricular zone
539:
537:Top expressed in
532:
511:
494:
484:
471:
460:
445:
438:
432:
421:
409:
393:
383:
370:
359:
344:
337:
331:
320:
306:
290:
284:
282:AKT1 - orthologs
235:
228:
205:
108:
102:
81:
80:
68:
59:
56:
35:Protein kinase B
27:
26:
19:
7218:
7217:
7213:
7212:
7211:
7209:
7208:
7207:
7203:Protein kinases
7178:
7177:
7149:
7144:
7109:
7066:
7029:
7009:(18): 2308–14.
7000:
6971:
6928:
6891:
6887:
6885:Further reading
6882:
6881:
6845:
6844:
6840:
6786:
6785:
6778:
6764:
6756:
6754:
6731:
6698:
6697:
6690:
6644:
6643:
6639:
6618:(20): 6376–82.
6609:
6608:
6604:
6568:
6567:
6563:
6527:
6526:
6522:
6499:(44): 34451–8.
6486:
6485:
6481:
6427:
6426:
6422:
6368:
6367:
6363:
6322:(43): 16584–9.
6309:
6308:
6304:
6268:
6267:
6263:
6250:(13): 3504–13.
6240:
6239:
6235:
6189:
6188:
6184:
6148:
6147:
6140:
6104:
6103:
6096:
6042:
6041:
6037:
6001:
6000:
5993:
5962:(16): 5962–74.
5956:Mol. Cell. Biol
5949:
5948:
5944:
5921:(6): 3897–902.
5908:
5907:
5903:
5867:
5866:
5862:
5831:(21): 7449–59.
5825:Mol. Cell. Biol
5818:
5817:
5813:
5772:(19): 11211–6.
5759:
5758:
5754:
5731:(29): 27462–9.
5718:
5717:
5710:
5687:(15): 12874–8.
5674:
5673:
5666:
5625:(20): 10832–7.
5612:
5611:
5607:
5571:
5570:
5566:
5522:
5521:
5517:
5473:
5472:
5468:
5431:(6748): 86–90.
5422:
5421:
5417:
5371:
5370:
5366:
5330:
5329:
5325:
5295:
5294:
5290:
5259:(24): 10040–4.
5246:
5245:
5241:
5218:(45): 32274–8.
5205:
5204:
5200:
5177:(35): 27354–9.
5164:
5163:
5159:
5128:(4): 1493–504.
5122:Mol. Cell. Biol
5115:
5114:
5110:
5065:
5064:
5060:
5006:
5005:
5001:
4947:
4946:
4942:
4904:
4903:
4899:
4862:N. Engl. J. Med
4854:
4853:
4849:
4840:
4839:
4835:
4822:
4821:
4817:
4804:
4803:
4799:
4787:
4778:
4766:
4757:
4752:
4747:
4735:
4727:
4725:
4720:
4632:Oxidoreductases
4618:
4594:Enzyme kinetics
4582:
4578:List of enzymes
4551:
4520:
4491:Catalytic triad
4469:
4464:
4434:
4421:
4369:
4347:
4271:
4254:
4237:
4220:
4191:
4051:
3951:
3922:P70-S6 Kinase 1
3892:
3783:
3745:
3723:
3689:
3665:
3626:
3592:
3298:
3269:
3245:
3226:
3147:
3123:
3084:
3040:
3023:
2999:
2993:Aurora C kinase
2988:Aurora B kinase
2983:Aurora A kinase
2963:
2944:
2910:
2881:
2814:
2780:
2636:
2622:
2608:
2578:
2573:
2570:
2564:
2555:
2549:
2540:
2534:
2525:
2519:
2510:
2504:
2490:
2487:
2432:
2427:
2237:
2197:
2177:large T antigen
2128:
2120:protein domains
2081:View/Edit Mouse
2076:View/Edit Human
2039:
2032:
2029:Location (UCSC)
2015:
2011:
2007:
1986:
1982:
1976:
1972:
1968:
1964:
1960:
1936:
1932:
1928:
1907:
1903:
1897:
1893:
1889:
1885:
1881:
1796:ENSG00000142208
1689:
1220:phosphorylation
903:
874:plasma membrane
822:
773:protein binding
728:kinase activity
688:
657:
648:
643:
639:
635:
631:
627:
623:
619:
615:
611:
597:
586:
581:
579:body of stomach
577:
573:
569:
565:
561:
557:
553:
549:
535:
479:
466:
458:
448:
447:
446:
439:
419:
396:Gene location (
378:
365:
357:
347:
346:
345:
338:
316:
293:Gene location (
244:
231:
224:
117:
95:
60:
54:
51:
28:
24:
17:
12:
11:
5:
7216:
7214:
7206:
7205:
7200:
7195:
7190:
7180:
7179:
7176:
7175:
7156:
7153:AKT1 Standards
7148:
7147:External links
7145:
7143:
7142:
7107:
7079:(3): 399–403.
7064:
7027:
6998:
6969:
6926:
6888:
6886:
6883:
6880:
6879:
6838:
6776:
6688:
6637:
6602:
6561:
6520:
6479:
6440:(13): 7200–5.
6420:
6361:
6302:
6261:
6233:
6182:
6161:(2): 395–407.
6138:
6117:(5): 3743–51.
6094:
6035:
6014:(5): 3517–23.
5991:
5942:
5901:
5860:
5811:
5752:
5708:
5664:
5605:
5564:
5535:(1–3): 180–6.
5515:
5486:(1–2): 72–82.
5466:
5415:
5380:(6748): 82–5.
5364:
5323:
5288:
5239:
5198:
5157:
5108:
5079:(7): 611–619.
5058:
5019:(14): 5034–7.
4999:
4940:
4897:
4847:
4833:
4815:
4797:
4776:
4754:
4753:
4751:
4748:
4746:
4745:
4722:
4721:
4719:
4718:
4705:
4692:
4679:
4666:
4653:
4640:
4626:
4624:
4620:
4619:
4617:
4616:
4611:
4606:
4601:
4596:
4590:
4588:
4584:
4583:
4581:
4580:
4575:
4570:
4565:
4559:
4557:
4556:Classification
4553:
4552:
4550:
4549:
4544:
4539:
4534:
4528:
4526:
4522:
4521:
4519:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4477:
4475:
4471:
4470:
4465:
4463:
4462:
4455:
4448:
4440:
4431:
4430:
4427:
4426:
4423:
4422:
4420:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4383:
4381:
4371:
4370:
4364:
4357:
4356:
4353:
4352:
4349:
4348:
4346:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4309:
4308:
4303:
4298:
4293:
4282:
4280:
4279:(EC 2.7.11.30)
4273:
4272:
4270:
4269:
4265:
4263:
4262:(EC 2.7.11.29)
4256:
4255:
4253:
4252:
4248:
4246:
4245:(EC 2.7.11.28)
4239:
4238:
4236:
4235:
4231:
4229:
4228:(EC 2.7.11.27)
4222:
4221:
4219:
4218:
4213:
4208:
4202:
4200:
4199:(EC 2.7.11.26)
4193:
4192:
4190:
4189:
4184:
4179:
4178:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4137:
4136:
4135:
4130:
4125:
4120:
4110:
4109:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4062:
4060:
4059:(EC 2.7.11.25)
4053:
4052:
4050:
4049:
4048:
4047:
4042:
4037:
4027:
4026:
4025:
4020:
4015:
4005:
4004:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3962:
3960:
3959:(EC 2.7.11.24)
3953:
3952:
3950:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3903:
3901:
3900:(EC 2.7.11.23)
3894:
3893:
3891:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3794:
3792:
3791:(EC 2.7.11.22)
3785:
3784:
3782:
3781:
3776:
3771:
3766:
3760:
3758:
3757:(EC 2.7.11.21)
3747:
3746:
3740:
3733:
3732:
3729:
3728:
3725:
3724:
3722:
3721:
3716:
3711:
3706:
3700:
3698:
3697:(EC 2.7.11.21)
3691:
3690:
3688:
3687:
3682:
3676:
3674:
3673:(EC 2.7.11.20)
3667:
3666:
3664:
3663:
3658:
3653:
3648:
3643:
3637:
3635:
3634:(EC 2.7.11.19)
3628:
3627:
3625:
3624:
3619:
3614:
3609:
3603:
3601:
3600:(EC 2.7.11.18)
3594:
3593:
3591:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3309:
3307:
3306:(EC 2.7.11.17)
3300:
3299:
3297:
3296:
3291:
3286:
3280:
3278:
3277:(EC 2.7.11.16)
3271:
3270:
3268:
3267:
3262:
3256:
3254:
3253:(EC 2.7.11.15)
3247:
3246:
3244:
3243:
3237:
3235:
3234:(EC 2.7.11.14)
3228:
3227:
3225:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3158:
3156:
3155:(EC 2.7.11.13)
3149:
3148:
3146:
3145:
3140:
3134:
3132:
3131:(EC 2.7.11.12)
3125:
3124:
3122:
3121:
3116:
3111:
3106:
3101:
3095:
3093:
3092:(EC 2.7.11.11)
3086:
3085:
3083:
3082:
3077:
3072:
3067:
3062:
3057:
3051:
3049:
3048:(EC 2.7.11.10)
3042:
3041:
3039:
3038:
3034:
3032:
3025:
3024:
3022:
3021:
3016:
3010:
3008:
3001:
3000:
2998:
2997:
2996:
2995:
2990:
2985:
2974:
2972:
2965:
2964:
2962:
2961:
2955:
2953:
2946:
2945:
2943:
2942:
2937:
2932:
2927:
2921:
2919:
2912:
2911:
2909:
2908:
2903:
2898:
2892:
2890:
2883:
2882:
2880:
2879:
2878:
2877:
2872:
2867:
2859:
2858:
2857:
2852:
2844:
2843:
2842:
2837:
2825:
2823:
2816:
2815:
2813:
2812:
2807:
2802:
2797:
2791:
2789:
2782:
2781:
2779:
2778:
2777:
2776:
2766:
2765:
2764:
2759:
2754:
2749:
2739:
2734:
2729:
2728:
2727:
2722:
2717:
2707:
2702:
2697:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2657:
2651:
2649:
2638:
2637:
2631:
2624:
2623:
2609:
2607:
2606:
2599:
2592:
2584:
2575:
2574:
2572:
2571:
2565:
2558:
2556:
2550:
2543:
2541:
2535:
2528:
2526:
2520:
2513:
2511:
2505:
2498:
2495:
2492:
2491:
2488:
2486:
2485:
2478:
2471:
2463:
2457:
2456:
2451:
2445:
2439:
2431:
2428:
2426:
2425:
2419:
2413:
2407:
2401:
2395:
2389:
2383:
2377:
2371:
2365:
2359:
2353:
2347:
2341:
2335:
2329:
2323:
2317:
2311:
2305:
2299:
2293:
2287:
2281:
2276:
2270:
2264:
2258:
2252:
2245:
2236:
2233:
2196:
2193:
2168:phosphorylates
2160:nervous system
2127:
2124:
2088:
2087:
2084:
2083:
2078:
2068:
2067:
2061:
2060:
2057:
2056:
2054:
2052:
2045:
2044:
2037:
2030:
2026:
2025:
2022:
2021:
2003:
2002:
1996:
1993:
1992:
1978:
1977:
1951:
1947:
1946:
1943:
1942:
1924:
1923:
1917:
1914:
1913:
1899:
1898:
1872:
1868:
1867:
1864:
1863:
1855:
1854:
1848:
1845:
1844:
1836:
1835:
1829:
1823:
1822:
1819:
1818:
1810:
1809:
1803:
1800:
1799:
1791:
1790:
1784:
1778:
1777:
1774:
1773:
1765:
1764:
1758:
1755:
1754:
1746:
1745:
1739:
1733:
1732:
1727:
1722:
1718:
1717:
1707:
1706:
1703:
1702:
1691:
1690:
1688:
1687:
1682:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1597:
1592:
1587:
1582:
1577:
1572:
1567:
1562:
1557:
1552:
1547:
1542:
1537:
1532:
1527:
1522:
1517:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
911:
909:
905:
904:
902:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
830:
828:
824:
823:
821:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
753:enzyme binding
750:
745:
740:
735:
730:
725:
719:
717:
713:
712:
702:
701:
698:
697:
694:
693:
685:
684:
673:
667:
666:
663:
662:
654:
653:
650:
649:
647:
646:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
603:
602:
591:
588:
587:
585:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
541:
540:
528:
527:
519:
508:
502:
501:
498:RNA expression
490:
489:
486:
485:
477:
473:
472:
464:
461:
456:
450:
449:
440:
433:
427:
423:
422:
417:
411:
410:
402:
401:
389:
388:
385:
384:
376:
372:
371:
363:
360:
355:
349:
348:
339:
332:
326:
322:
321:
314:
308:
307:
299:
298:
286:
285:
242:
238:
237:
229:
221:
220:
216:
215:
212:
211:
208:
207:
113:
112:
104:
103:
92:
86:
85:
77:
76:
73:
72:
62:
61:
55:September 2017
31:
29:
22:
15:
13:
10:
9:
6:
4:
3:
2:
7215:
7204:
7201:
7199:
7196:
7194:
7191:
7189:
7186:
7185:
7183:
7173:
7169:
7168:
7163:
7162:
7157:
7154:
7151:
7150:
7146:
7139:
7135:
7130:
7125:
7121:
7117:
7116:Endocrinology
7113:
7108:
7104:
7100:
7095:
7090:
7086:
7082:
7078:
7074:
7070:
7065:
7061:
7057:
7053:
7049:
7045:
7041:
7038:(2): E192–8.
7037:
7033:
7028:
7024:
7020:
7016:
7012:
7008:
7004:
6999:
6995:
6991:
6987:
6983:
6979:
6975:
6970:
6966:
6962:
6957:
6952:
6948:
6944:
6941:(3): 561–76.
6940:
6936:
6932:
6927:
6923:
6919:
6915:
6911:
6907:
6903:
6899:
6895:
6890:
6889:
6884:
6875:
6871:
6866:
6861:
6857:
6853:
6852:J. Biol. Chem
6849:
6842:
6839:
6834:
6830:
6825:
6820:
6815:
6810:
6806:
6802:
6798:
6794:
6790:
6783:
6781:
6777:
6768:
6760:
6753:
6752:
6747:
6743:
6739:
6735:
6728:
6724:
6719:
6714:
6710:
6706:
6705:J. Biol. Chem
6702:
6695:
6693:
6689:
6684:
6680:
6676:
6672:
6668:
6664:
6660:
6656:
6652:
6648:
6641:
6638:
6633:
6629:
6625:
6621:
6617:
6613:
6606:
6603:
6598:
6594:
6589:
6584:
6580:
6576:
6575:J. Biol. Chem
6572:
6565:
6562:
6557:
6553:
6548:
6543:
6539:
6535:
6534:J. Biol. Chem
6531:
6524:
6521:
6516:
6512:
6507:
6502:
6498:
6494:
6493:J. Biol. Chem
6490:
6483:
6480:
6475:
6471:
6466:
6461:
6456:
6451:
6447:
6443:
6439:
6435:
6431:
6424:
6421:
6416:
6412:
6407:
6402:
6397:
6392:
6388:
6384:
6381:(7): 3690–4.
6380:
6376:
6372:
6365:
6362:
6357:
6353:
6348:
6343:
6338:
6333:
6329:
6325:
6321:
6317:
6313:
6306:
6303:
6298:
6294:
6289:
6284:
6280:
6276:
6275:J. Biol. Chem
6272:
6265:
6262:
6257:
6253:
6249:
6245:
6237:
6234:
6229:
6225:
6221:
6217:
6213:
6209:
6205:
6201:
6197:
6193:
6186:
6183:
6178:
6174:
6169:
6164:
6160:
6156:
6152:
6145:
6143:
6139:
6134:
6130:
6125:
6120:
6116:
6112:
6111:J. Biol. Chem
6108:
6101:
6099:
6095:
6090:
6086:
6081:
6076:
6071:
6066:
6062:
6058:
6055:(9): 3622–7.
6054:
6050:
6046:
6039:
6036:
6031:
6027:
6022:
6017:
6013:
6009:
6008:J. Biol. Chem
6005:
5998:
5996:
5992:
5987:
5983:
5978:
5973:
5969:
5965:
5961:
5957:
5953:
5946:
5943:
5938:
5934:
5929:
5924:
5920:
5916:
5915:J. Biol. Chem
5912:
5905:
5902:
5897:
5893:
5888:
5883:
5880:(4): 2573–8.
5879:
5875:
5874:J. Biol. Chem
5871:
5864:
5861:
5856:
5852:
5847:
5842:
5838:
5834:
5830:
5826:
5822:
5815:
5812:
5807:
5803:
5798:
5793:
5788:
5783:
5779:
5775:
5771:
5767:
5763:
5756:
5753:
5748:
5744:
5739:
5734:
5730:
5726:
5725:J. Biol. Chem
5722:
5715:
5713:
5709:
5704:
5700:
5695:
5690:
5686:
5682:
5681:J. Biol. Chem
5678:
5671:
5669:
5665:
5660:
5656:
5651:
5646:
5641:
5636:
5632:
5628:
5624:
5620:
5616:
5609:
5606:
5601:
5597:
5592:
5587:
5584:(9): 5261–9.
5583:
5579:
5575:
5568:
5565:
5560:
5556:
5552:
5548:
5543:
5538:
5534:
5530:
5526:
5519:
5516:
5511:
5507:
5502:
5497:
5493:
5489:
5485:
5481:
5477:
5470:
5467:
5462:
5458:
5454:
5450:
5446:
5445:10.1038/43474
5442:
5438:
5434:
5430:
5426:
5419:
5416:
5411:
5407:
5403:
5399:
5395:
5394:10.1038/43466
5391:
5387:
5383:
5379:
5375:
5368:
5365:
5360:
5356:
5351:
5346:
5342:
5338:
5337:J. Biol. Chem
5334:
5327:
5324:
5319:
5315:
5311:
5307:
5303:
5299:
5292:
5289:
5284:
5280:
5275:
5270:
5266:
5262:
5258:
5254:
5250:
5243:
5240:
5235:
5231:
5226:
5221:
5217:
5213:
5212:J. Biol. Chem
5209:
5202:
5199:
5194:
5190:
5185:
5180:
5176:
5172:
5171:J. Biol. Chem
5168:
5161:
5158:
5153:
5149:
5144:
5139:
5135:
5131:
5127:
5123:
5119:
5112:
5109:
5104:
5100:
5095:
5090:
5086:
5082:
5078:
5074:
5070:
5062:
5059:
5054:
5050:
5045:
5040:
5035:
5030:
5026:
5022:
5018:
5014:
5010:
5003:
5000:
4995:
4991:
4986:
4981:
4976:
4971:
4967:
4963:
4960:(7): 3065–7.
4959:
4955:
4951:
4944:
4941:
4936:
4932:
4928:
4924:
4920:
4916:
4912:
4908:
4901:
4898:
4893:
4889:
4884:
4879:
4875:
4871:
4867:
4863:
4859:
4851:
4848:
4843:
4837:
4834:
4829:
4825:
4819:
4816:
4811:
4807:
4801:
4798:
4794:
4790:
4785:
4783:
4781:
4777:
4773:
4769:
4764:
4762:
4760:
4756:
4749:
4744:
4739:
4734:
4730:
4716:
4712:
4711:
4706:
4703:
4699:
4698:
4693:
4690:
4686:
4685:
4680:
4677:
4673:
4672:
4667:
4664:
4660:
4659:
4654:
4651:
4647:
4646:
4641:
4638:
4634:
4633:
4628:
4627:
4625:
4621:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4591:
4589:
4585:
4579:
4576:
4574:
4573:Enzyme family
4571:
4569:
4566:
4564:
4561:
4560:
4558:
4554:
4548:
4545:
4543:
4540:
4538:
4537:Cooperativity
4535:
4533:
4530:
4529:
4527:
4523:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4496:Oxyanion hole
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4478:
4476:
4472:
4468:
4461:
4456:
4454:
4449:
4447:
4442:
4441:
4438:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4384:
4382:
4380:
4376:
4372:
4367:
4362:
4358:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4288:
4287:
4284:
4283:
4281:
4278:
4274:
4267:
4266:
4264:
4261:
4257:
4250:
4249:
4247:
4244:
4240:
4233:
4232:
4230:
4227:
4223:
4217:
4214:
4212:
4209:
4207:
4204:
4203:
4201:
4198:
4194:
4188:
4185:
4183:
4180:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4142:
4141:
4138:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4115:
4114:
4111:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4068:
4067:
4064:
4063:
4061:
4058:
4054:
4046:
4043:
4041:
4038:
4036:
4033:
4032:
4031:
4028:
4024:
4021:
4019:
4016:
4014:
4011:
4010:
4009:
4006:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3968:
3967:
3964:
3963:
3961:
3958:
3954:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3904:
3902:
3899:
3895:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3790:
3786:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3761:
3759:
3756:
3752:
3748:
3743:
3738:
3734:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3701:
3699:
3696:
3692:
3686:
3683:
3681:
3678:
3677:
3675:
3672:
3668:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3638:
3636:
3633:
3629:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3604:
3602:
3599:
3595:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3310:
3308:
3305:
3301:
3295:
3292:
3290:
3287:
3285:
3282:
3281:
3279:
3276:
3272:
3266:
3263:
3261:
3258:
3257:
3255:
3252:
3248:
3242:
3239:
3238:
3236:
3233:
3229:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3159:
3157:
3154:
3150:
3144:
3141:
3139:
3136:
3135:
3133:
3130:
3126:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3096:
3094:
3091:
3087:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3052:
3050:
3047:
3043:
3036:
3035:
3033:
3031:(EC 2.7.11.9)
3030:
3026:
3020:
3017:
3015:
3012:
3011:
3009:
3007:(EC 2.7.11.8)
3006:
3002:
2994:
2991:
2989:
2986:
2984:
2981:
2980:
2979:
2978:Aurora kinase
2976:
2975:
2973:
2971:(EC 2.7.11.7)
2970:
2966:
2960:
2957:
2956:
2954:
2952:(EC 2.7.11.6)
2951:
2947:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2922:
2920:
2918:(EC 2.7.11.5)
2917:
2913:
2907:
2904:
2902:
2899:
2897:
2894:
2893:
2891:
2889:(EC 2.7.11.4)
2888:
2884:
2876:
2873:
2871:
2868:
2866:
2863:
2862:
2860:
2856:
2853:
2851:
2848:
2847:
2845:
2841:
2838:
2836:
2833:
2832:
2830:
2827:
2826:
2824:
2822:(EC 2.7.11.3)
2821:
2817:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2792:
2790:
2788:(EC 2.7.11.2)
2787:
2783:
2775:
2772:
2771:
2770:
2767:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2744:
2743:
2742:EIF-2 kinases
2740:
2738:
2735:
2733:
2730:
2726:
2723:
2721:
2718:
2716:
2713:
2712:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2652:
2650:
2648:(EC 2.7.11.1)
2647:
2643:
2639:
2634:
2629:
2625:
2620:
2616:
2612:
2605:
2600:
2598:
2593:
2591:
2586:
2585:
2582:
2568:
2562:
2557:
2553:
2547:
2542:
2538:
2532:
2527:
2523:
2517:
2512:
2508:
2502:
2497:
2493:
2484:
2479:
2477:
2472:
2470:
2465:
2464:
2461:
2455:
2452:
2449:
2446:
2443:
2440:
2437:
2434:
2433:
2429:
2423:
2420:
2417:
2414:
2411:
2408:
2405:
2402:
2399:
2396:
2393:
2390:
2387:
2384:
2381:
2378:
2375:
2372:
2369:
2366:
2363:
2360:
2357:
2354:
2351:
2348:
2345:
2342:
2339:
2336:
2333:
2330:
2327:
2324:
2321:
2318:
2315:
2312:
2309:
2306:
2303:
2300:
2297:
2294:
2291:
2288:
2285:
2282:
2280:
2277:
2274:
2271:
2268:
2265:
2262:
2259:
2256:
2253:
2250:
2247:
2246:
2244:
2242:
2234:
2232:
2228:
2226:
2222:
2217:
2214:
2210:
2206:
2202:
2194:
2192:
2190:
2186:
2182:
2178:
2174:
2169:
2165:
2161:
2157:
2153:
2149:
2148:growth factor
2145:
2141:
2137:
2133:
2125:
2123:
2121:
2117:
2114:that contain
2113:
2110:subfamily of
2109:
2105:
2102:
2098:
2094:
2082:
2077:
2073:
2069:
2066:
2062:
2055:
2053:
2050:
2046:
2042:
2038:
2035:
2031:
2027:
2020:
2018:
2014:
2010:
2004:
2000:
1997:
1991:
1989:
1985:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1952:
1948:
1941:
1939:
1935:
1931:
1925:
1921:
1918:
1912:
1910:
1906:
1900:
1896:
1892:
1888:
1884:
1880:
1876:
1873:
1871:RefSeq (mRNA)
1869:
1862:
1861:
1856:
1852:
1849:
1843:
1842:
1837:
1833:
1830:
1828:
1824:
1817:
1816:
1811:
1807:
1804:
1798:
1797:
1792:
1788:
1785:
1783:
1779:
1772:
1771:
1766:
1762:
1759:
1753:
1752:
1747:
1743:
1740:
1738:
1734:
1731:
1728:
1726:
1723:
1719:
1716:
1712:
1708:
1701:
1697:
1692:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1648:
1646:
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1638:
1636:
1633:
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1628:
1626:
1623:
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1618:
1616:
1613:
1611:
1608:
1606:
1603:
1601:
1598:
1596:
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1588:
1586:
1583:
1581:
1578:
1576:
1573:
1571:
1568:
1566:
1563:
1561:
1558:
1556:
1553:
1551:
1548:
1546:
1543:
1541:
1538:
1536:
1533:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1510:TOR signaling
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1466:
1463:
1461:
1458:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
912:
910:
907:
906:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
854:mitochondrion
852:
850:
847:
845:
842:
840:
837:
835:
832:
831:
829:
826:
825:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
720:
718:
715:
714:
711:
710:Gene ontology
707:
703:
691:
686:
682:
677:
674:
672:
668:
660:
655:
644:
640:
636:
632:
628:
624:
620:
616:
612:
608:
607:
604:
600:
595:
592:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
545:
542:
538:
533:
530:
529:
526:
524:
520:
518:
517:
513:
512:
509:
507:
503:
499:
495:
491:
483:
478:
474:
470:
465:
455:
451:
444:
437:
431:
424:
416:
412:
408:
403:
399:
394:
390:
382:
377:
373:
369:
364:
354:
350:
343:
336:
330:
323:
319:
313:
309:
305:
300:
296:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
239:
234:
227:
222:
217:
206:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
114:
109:
106:
105:
101:
98:
91:
87:
82:
78:
74:
69:
66:
58:
49:
45:
41:
37:
36:
30:
21:
20:
7166:
7160:
7122:(3): 942–7.
7119:
7115:
7076:
7073:J. Cell Biol
7072:
7035:
7031:
7006:
7002:
6980:: 965–1014.
6977:
6973:
6938:
6934:
6897:
6893:
6855:
6851:
6841:
6796:
6792:
6765:{{
6757:{{
6750:
6748:,
6708:
6704:
6650:
6646:
6640:
6615:
6612:Biochemistry
6611:
6605:
6578:
6574:
6564:
6537:
6533:
6523:
6496:
6492:
6482:
6437:
6433:
6423:
6378:
6374:
6364:
6319:
6315:
6305:
6278:
6274:
6264:
6247:
6243:
6236:
6195:
6191:
6185:
6158:
6154:
6114:
6110:
6052:
6048:
6038:
6011:
6007:
5959:
5955:
5945:
5918:
5914:
5904:
5877:
5873:
5863:
5828:
5824:
5814:
5769:
5765:
5755:
5728:
5724:
5684:
5680:
5622:
5618:
5608:
5581:
5577:
5567:
5532:
5528:
5518:
5483:
5479:
5469:
5428:
5424:
5418:
5377:
5373:
5367:
5340:
5336:
5326:
5301:
5297:
5291:
5256:
5252:
5242:
5215:
5211:
5201:
5174:
5170:
5160:
5125:
5121:
5111:
5076:
5072:
5061:
5016:
5012:
5002:
4957:
4953:
4943:
4913:(2): 111–9.
4910:
4906:
4900:
4868:(7): 611–9.
4865:
4861:
4850:
4836:
4827:
4818:
4809:
4800:
4710:Translocases
4707:
4694:
4681:
4668:
4655:
4645:Transferases
4642:
4629:
4486:Binding site
3917:P70S6 kinase
2714:
2566:
2551:
2536:
2521:
2506:
2238:
2235:Interactions
2229:
2225:Elephant Man
2220:
2218:
2198:
2181:Neu oncogene
2129:
2100:
2092:
2091:
2013:NP_001318036
2009:NP_001159366
2006:
1988:NP_001369362
1984:NP_001369361
1981:
1974:NP_001369360
1970:NP_001369359
1962:NP_001014432
1958:NP_001014431
1938:NM_001331107
1930:NM_001165894
1927:
1909:NM_001382433
1905:NM_001382432
1902:
1895:NM_001382431
1891:NM_001382430
1883:NM_001014432
1879:NM_001014431
1858:
1839:
1813:
1794:
1768:
1749:
1729:
1724:
1365:human ageing
521:
514:
480:112,641,318
467:112,620,255
379:104,795,751
366:104,769,349
241:External IDs
116:
65:
52:
42:from it and
33:
4907:Clin. Genet
4481:Active site
4368:(EC 2.7.12)
3755:Polo kinase
3695:Polo kinase
2489:PDB gallery
2136:fibroblasts
894:postsynapse
884:nucleoplasm
738:ATP binding
625:human fetus
613:granulocyte
575:gallbladder
219:Identifiers
7182:Categories
6935:Biochem. J
6244:Cancer Res
5578:J. Immunol
5253:Cancer Res
4795:, May 2017
4774:, May 2017
4750:References
4684:Isomerases
4658:Hydrolases
4525:Regulation
3046:IÎşB kinase
2621:2.7.11-12)
2205:retrovirus
525:(ortholog)
262:HomoloGene
7198:Oncogenes
7193:EC 2.7.11
6767:retracted
6759:retracted
6155:Mol. Cell
5529:FEBS Lett
5461:205033347
4935:204999819
4563:EC number
3172:PKC alpha
2164:apoptosis
2146:-derived
2017:NP_033782
1966:NP_005154
1934:NM_009652
1887:NM_005163
1715:Orthologs
834:cytoplasm
270:GeneCards
7138:16946008
7103:15533996
7060:25834366
7052:15271644
7023:11710897
6994:10872470
6965:10698680
6874:11956222
6833:15342917
6746:27825086
6727:12167664
6683:43360696
6675:12791994
6632:12009899
6597:15187088
6556:11410591
6515:10926925
6474:11404460
6415:11274386
6356:18931307
6297:14970221
6256:10910062
6228:45837814
6220:15718470
6177:10983986
6133:11707444
6089:18292230
6030:11042204
5986:12138205
5937:12458207
5896:11707464
5855:11585925
5747:11313365
5703:11825911
5659:10995457
5600:15843522
5559:26111467
5551:12586360
5510:11782427
5453:10485711
5402:10485710
5359:12042314
5318:10576742
5283:19074868
5234:10542266
5193:10869359
5152:14749367
5103:21793738
4927:23992099
4892:21793738
4791:–
4770:–
4587:Kinetics
4511:Cofactor
4474:Activity
3528:KIAA0999
3423:MAPKAPK5
3418:MAPKAPK3
3413:MAPKAPK2
2430:See also
2332:MAPKAPK2
2290:HSP90AA1
2241:interact
2213:AKR mice
2201:oncogene
2144:platelet
2126:Function
2065:Wikidata
1694:Sources:
844:membrane
358:14q32.33
7094:2172491
6956:1220886
6922:5224712
6914:9019819
6894:Science
6801:Bibcode
6655:Bibcode
6647:Science
6442:Bibcode
6383:Bibcode
6347:2569968
6324:Bibcode
6200:Bibcode
6192:Science
6080:2265134
6057:Bibcode
5806:9736715
5774:Bibcode
5627:Bibcode
5433:Bibcode
5410:4419076
5382:Bibcode
5298:Science
5274:2605656
5094:3170413
5053:3037531
5021:Bibcode
4962:Bibcode
4883:3170413
4793:Ensembl
4772:Ensembl
4743:Biology
4697:Ligases
4467:Enzymes
4187:MAP3K14
4165:MAP3K11
4160:MAP3K10
4150:MAP3K13
4145:MAP3K12
3947:RPS6KC1
3942:RPS6KA1
3937:RPS6KA3
3932:RPS6KA2
3927:RPS6KB2
3912:RPS6KA4
3907:RPS6KA5
3558:Kalirin
3523:SNF1LK2
2762:EIF2AK4
2757:EIF2AK3
2611:Kinases
2314:MAP3K11
2209:thymoma
2195:History
2179:or the
1827:UniProt
1782:Ensembl
1721:Species
1700:QuickGO
1515:anoikis
889:vesicle
879:spindle
859:nucleus
839:cytosol
500:pattern
226:Aliases
48:Discuss
7158:Human
7136:
7101:
7091:
7058:
7050:
7021:
6992:
6963:
6953:
6920:
6912:
6872:
6831:
6824:518784
6821:
6744:
6740:,
6725:
6681:
6673:
6630:
6595:
6554:
6513:
6472:
6462:
6413:
6403:
6354:
6344:
6295:
6254:
6226:
6218:
6175:
6131:
6087:
6077:
6028:
5984:
5977:133991
5974:
5935:
5894:
5853:
5843:
5804:
5794:
5745:
5701:
5657:
5647:
5598:
5557:
5549:
5508:
5501:125816
5498:
5480:EMBO J
5459:
5451:
5425:Nature
5408:
5400:
5374:Nature
5357:
5316:
5281:
5271:
5232:
5191:
5150:
5143:344167
5140:
5101:
5091:
5051:
5044:305241
5041:
4994:197531
4992:
4985:431413
4982:
4933:
4925:
4890:
4880:
4729:Portal
4671:Lyases
4417:MAP2K7
4412:MAP2K6
4407:MAP2K5
4402:MAP2K4
4397:MAP2K3
4392:MAP2K2
4387:MAP2K1
4338:ACVRL1
4333:ACVR2B
4328:ACVR2A
4323:ACVR1C
4318:ACVR1B
4301:BMPR1B
4296:BMPR1A
4170:MAP3K7
4155:MAP3K9
4106:MAP3K8
4101:MAP3K7
4096:MAP3K6
4091:MAP3K5
4086:MAP3K4
4081:MAP3K3
4076:MAP3K2
4071:MAP3K1
4045:MAPK14
4040:MAPK13
4035:MAPK11
4023:MAPK10
4001:MAPK15
3996:MAPK12
3888:CDC2L1
3863:CDC2L5
3538:SNF1LK
3363:CAMK2G
3358:CAMK2D
3353:CAMK2B
3348:CAMK2A
3338:CAMK1G
3333:CAMK1D
3328:CAMK1B
3323:CAMK1A
3177:PRKCB1
3114:PRKACA
3109:PRKACB
3104:PRKACG
3080:IKBKAP
2906:BCKDHB
2901:BCKDHA
2875:PRKAG3
2870:PRKAG2
2865:PRKAG1
2855:PRKAB2
2850:PRKAB1
2840:PRKAA2
2835:PRKAA1
2680:STK38L
2418:, and
2392:PLXNA1
2326:MAPK14
2320:MAP3K8
2308:MAP2K4
2273:CDKN1B
2243:with:
2097:enzyme
2095:is an
2051:search
2049:PubMed
1860:P31750
1841:P31749
1737:Entrez
671:BioGPS
617:atrium
250:164730
44:merged
7056:S2CID
6918:S2CID
6763:with
6679:S2CID
6465:34646
6406:31113
6224:S2CID
5846:99917
5797:21621
5650:27109
5555:S2CID
5457:S2CID
5406:S2CID
4931:S2CID
4623:Types
4379:MAP2K
4313:ACVR1
4306:BMPR2
4291:BMPR1
4216:GSK-3
4057:MAP3K
4018:MAPK9
4013:MAPK8
3991:MAPK7
3986:MAPK6
3981:MAPK4
3976:MAPK3
3971:MAPK1
3883:PFTK1
3878:PCTK3
3873:PCTK2
3868:PCTK1
3858:CDK12
3853:CDK10
3828:CDKL5
3808:CDKL2
3685:STK19
3680:EEF2K
3661:PHKG2
3656:PHKG1
3646:PHKA2
3641:PHKA1
3622:MYLK4
3617:MYLK3
3612:MYLK2
3588:DCLK1
3583:Titin
3573:TRIB3
3568:TRIB2
3563:TRIB1
3553:TSSK2
3533:STK40
3518:PSKH1
3513:PRKD3
3508:PRKD2
3488:PHKG2
3483:PHKG1
3473:OBSCN
3468:NUAK2
3463:NUAK1
3458:MKNK2
3453:MKNK1
3443:MARK4
3438:MARK3
3433:MARK2
3428:MARK1
3408:STK11
3403:DAPK3
3398:DAPK2
3393:DAPK1
3388:CHEK2
3383:CHEK1
3368:CAMK4
3343:CAMK2
3318:CAMK1
3313:BRSK2
3207:PRKCQ
3202:PRKCI
3197:PRKCG
3192:PRKCH
3187:PRKCE
3182:PRKCD
3143:PRKG1
3075:IKBKG
3070:IKBKE
3019:STK10
3014:FASTK
2940:IDH3G
2935:IDH3B
2930:IDH3A
2896:BCKDK
2690:ROCK1
2675:STK38
2670:MAST2
2665:MAST1
2660:LATS2
2655:LATS1
2422:YWHAZ
2404:TRIB3
2398:TCL1A
2386:PDPK1
2380:PRKCQ
2368:NR3C4
2362:NR4A1
2344:MTCP1
2338:MARK2
2302:KRT10
2267:C-Raf
2261:BRCA1
2249:AKTIP
1770:11651
1730:Mouse
1725:Human
1696:Amigo
621:molar
523:Mouse
516:Human
463:Start
398:Mouse
362:Start
295:Human
258:87986
40:split
7167:AKT1
7161:AKT1
7134:PMID
7099:PMID
7048:PMID
7019:PMID
7003:JAMA
6990:PMID
6961:PMID
6910:PMID
6870:PMID
6829:PMID
6742:PMID
6723:PMID
6671:PMID
6628:PMID
6593:PMID
6552:PMID
6511:PMID
6470:PMID
6411:PMID
6352:PMID
6293:PMID
6252:PMID
6216:PMID
6173:PMID
6129:PMID
6085:PMID
6026:PMID
5982:PMID
5933:PMID
5892:PMID
5851:PMID
5802:PMID
5743:PMID
5699:PMID
5655:PMID
5596:PMID
5547:PMID
5506:PMID
5449:PMID
5398:PMID
5355:PMID
5314:PMID
5279:PMID
5230:PMID
5189:PMID
5148:PMID
5099:PMID
5049:PMID
4990:PMID
4923:PMID
4888:PMID
4715:list
4708:EC7
4702:list
4695:EC6
4689:list
4682:EC5
4676:list
4669:EC4
4663:list
4656:EC3
4650:list
4643:EC2
4637:list
4630:EC1
4206:TPK1
4182:CDC7
4140:MLKs
4133:KSR2
4128:KSR1
4123:BRAF
4118:ARAF
4113:RAFs
3848:CDK9
3843:CDK8
3838:CDK7
3833:CDK6
3823:CDK5
3818:CDK4
3813:CDK3
3803:CDK2
3798:CDK1
3779:PLK4
3774:PLK3
3769:PLK2
3764:PLK1
3719:PLK4
3714:PLK3
3709:PLK2
3704:PLK1
3651:PHKB
3607:MYLK
3578:TRIO
3548:SPEG
3543:SNRK
3503:PKD1
3498:PIM2
3493:PIM1
3478:PASK
3448:MELK
3378:CASK
3373:MLCK
3294:GRK6
3289:GRK5
3284:GRK4
3222:PKN3
3217:PKN2
3119:PRKY
3065:TBK1
3060:IKK2
3055:CHUK
2959:STK4
2925:IDH2
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