302:
279:
176:
201:
553:
29:
308:
207:
4510:
1496:
for ALOX12 include 12S-Lipoxygenase, platelet-type 12-lipoxygenase, arachidonate:oxygen 12-oxidoreductase, Delta12-lipoxygenase, 12Delta-lipoxygenase, and C-12 lipoxygenase. ALOX12, often termed plate platelet-type 12-lipoxygenase, is distinguished from leukocyte-type 12-lipoxygenase which is found
2279:-diETE. While these compounds have not been thoroughly evaluated for bioactivity, 17-hydroperoxy-HDHA and the reduced product to which it is rapidly converted in cells, 17-hydroxy-HDHA, have been shown to inhibit the growth of cultured human prostate cancer cell by causing them to enter
55:
2644:)-HETE metabolic pathway has dual functions in promoting or inhibiting platelet responses depending on the stimulating agent and response studied but that inhibiting ALOX12 may ultimately prove useful in inhibiting platelet-related blood clotting.
4350:
Chen BK, Tsai TY, Huang HS, Chen LC, Chang WC, Tsai SB, Chang WC (2003). "Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene".
1690:)-hydroperoxy-5,8,10,14-eicosatetraenoic acid; this activity was the first mammalian lipoxygenase activity to be characterized. In 1975, the first biological activity was attached to this metabolite in studies showing that it simulated the
4427:"12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells"
2452:)-HETE are likewise implicated in essential hypertension (see next section). Hence, ALOX12 and its metabolite(s) may contribute to the development and/or progression of obesity, diabetes, hypertension, and/or the metabolic syndrome.
1572:)-HpETE and therefore is not regarded as a 12/15-lipoxygenase. Studies on the role of ALOX12 in pathophysiology using the main models for such functional studies, rats and mice, are complicated because neither species possesses a
3841:
Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R (July 2014).
4212:
Hagmann W, Gao X, Timar J, Chen YQ, Strohmaier AR, Fahrenkopf C, Kagawa D, Lee M, Zacharek A, Honn KV (November 1996). "12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization".
2199:(LTA4) in a two cellular reaction termed transcellular metabolism: human neutrophils metabolize arachidonic acid to its 5,6-epoxide, LTA4, and releases this intermediate to nearby neutrophils which metabolize it to lipoxin A4 (5
2552:)-HETE, and a 12/15-lipoxygenase type enzyme in the development and progression of the Alzhiemer's disease-like symptoms and findings in these animals. In a single study, ALOX12 mRNA was found elevated in the brain tissue of
4161:
Hussain H, Shornick LP, Shannon VR, Wilson JD, Funk CD, Pentland AP, Holtzman MJ (January 1994). "Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis".
2038:(i.e. itching) in the skin, and regulates regional blood flow in animal models; it also promotes the malignant behavior of cultured human cancer cells as well as the growth of certain cancers in animal models (see
4460:
Fridman C, Ojopi EP, Gregório SP, Ikenaga EH, Moreno DH, Demetrio FN, Guimarães PE, Vallada HP, Gattaz WF, Dias Neto E (February 2003). "Association of a new polymorphism in ALOX12 gene with bipolar disorder".
4279:
Nigam S, Kumar GS, Sutherland M, Schewe T, Ikawa H, Yamasaki Y, Ueda N, Yamamoto S (September 1999). "Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma".
2408:(i.e. gamma cells) of the pancreas islets appear to be the major if not only site where ALOX12 is expressed in these patients. The studies propose that in the islets of Langerhans ALOX12 and its 12(
4542:
3691:
Angulo JC, Lopez JI, Dorado JF, Sanchez-Chapado M, Colas B, Ropero S (2016). "A DNA Hypermethylation
Profile Independently Predicts Biochemical Recurrence Following Radical Prostatectomy".
3413:
Porro B, Songia P, Squellerio I, Tremoli E, Cavalca V (August 2014). "Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product".
1596:
in humans due to differences in these two enzymes' metabolic activities. The function of ALOX12 is further clouded by human ALOX15 which metabolizes arachidonic acid primarily to 15(
2259:). ALOX12 may also metabolize lesser amounts of DHA to secondary products including 17-hydroperoxy-DHA, 11-hydroperoxy-DHA, and 8,14-dihydroxy-DHA ALOX12 may likewise metabolize 5(
4242:
Nakamura M, Yamamoto S, Ishimura K (May 1997). "Subcellular localization of arachidonate 12-lipoxygenase and morphological effect of its overexpression on murine keratinocytes".
3102:
Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C, Tanabe T, Toh H (November 1990). "Molecular cloning and expression of human arachidonate 12-lipoxygenase".
315:
214:
2480:)-HETE also stimulates human prostate cell lines to produce VEGF. These results suggest that growth responses to the two growth factors involves their stimulation of 12(
1456:
2484:)-HETE production by endothelial cells and therefore that ALOX12 may be a target for reducing the neo-vascularization that promotes arthritic and cancer diseases. 12(
4388:
Winer I, Normolle DP, Shureiqi I, Sondak VK, Johnson T, Su L, Brenner DE (October 2002). "Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis".
5234:
4535:
1475:
4191:
Arora JK, Lysz TW, Zelenka PS (June 1996). "A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin".
2588:(i.e. Matrix metallopeptidase 9); selective (but not entirely) specific ALOX12 inhibitors reduced the proliferation and survival of these cells (see also
2556:
patients compared to control patients. These results suggest that ALOX12 (or ALOX15) may contribute to the development of
Alzheimer's disease in humans.
2493:
961:
4528:
3734:
Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening".
942:
137:
5638:
5604:
2536:)-HETE) in cerebrospinal fluid compared to aged-matched normal individuals. Complementary studies in rodent models bearing human mutated genes for
1497:
in mice, rats, cows, and pigs but not humans. Leukocyte-type 12-lipoxygenase in these animal species shares 73-86% amino acid identity with human
3486:
Serhan CN (2005). "Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution".
3451:
Weylandt KH (November 2015). "Docosapentaenoic acid derived metabolites and mediators - The new world of lipid mediator medicine in a nutshell".
2821:
6102:
6092:
2744:
2600:
gene in prostate cancer tissue was associated with clinical predictors for a high rate of recurrent disease. Some studies have found that 12(
2726:
301:
5732:
4778:
4768:
4293:
3894:
4062:
Flatman S, Morgan A, McDonald-Gibson RG, Davey A, Jonas GE, Slater TF (May 1988). "12-Lipoxygenase activity in human uterine cervix".
2581:
2469:
2448:
gene was significantly associated with total and percentage fat mass of obese compared to non-obese young
Chinese men. ALOX12 and 12(
1176:
278:
5813:
1169:
1468:
5572:
5078:
5015:
4842:
4763:
2604:)-HETE also promotes the growth and/or related pro-malignant behaviors of various other types of cultured cancer cell lines (see
1683:
1501:
but only 57-66% identity with human platelet-type 12-lipoxygenase and, like ALOX15, metabolizes arachidonic acid primarily to 15(
5412:
4758:
4615:
2713:
2692:
1975:
1526:
1419:
1611:
ALOX12 is also distinguished from arachidonate 12-lipoxygenase, 12R type (ALOX12B), which metabolizes arachidonic acid to the
5330:
5302:
5173:
4828:
4773:
2465:
2437:
1395:
640:
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
200:
175:
5969:
3900:
2709:
1698:. During the several years thereafter, human ALOX12 was purified, characterized biochemically, and had its gene molecularly
52:
5722:
4500:
2688:
5698:
5684:
5631:
5597:
5312:
5274:
117:
2596:)-HETE product may contribute to the growth and spread of prostate cancer in humans. Recently, hypermethylation of the
2046:)-HETE are the predominant substrates and products, respectively, of ALOX12, the enzyme also metabolizes other PUFA.
5737:
5693:
5679:
5135:
2609:
1743:
314:
213:
2564:
Studies in prostate cancer find that human prostate cancer cell lines in culture overexpress ALOX12, overproduce 12(
2112:
Then, ALOX12 or an unidentified epoxidase-type enzyme may metabolize this intermediate to an epoxide, 13,14-epoxy-4(
5557:
1735:
307:
206:
5954:
3652:"A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE"
1413:
6070:
6057:
6044:
6031:
6018:
6005:
5992:
5771:
5752:
5707:
5664:
4739:
4596:
4011:"Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase"
2537:
2497:
5964:
5918:
5861:
5655:
5503:
5471:
5350:
2381:
1751:
1400:
1306:
1232:
1006:
125:
2195:(SPMs) which possess anti-inflammatory, pain-alleviating, and other defensive activities. ALOX12 also acts on
3523:"15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival"
2488:)-HETE also dilates human coronary microcirculation arteries by activating these vessels' smooth muscle BKca
5866:
5624:
5439:
5249:
4582:
4565:
2413:
987:
5493:
1480:
5429:
2525:
2505:
2336:
1942:), regulate regional blood flow, and contribute to the regulation of blood pressure in animal models (see
1388:
1548:
are commonly termed 12/15-lipoxygenases based on their ability to metabolize arachidonic acid to both 12(
5887:
5806:
5292:
5216:
4571:
1662:
ALOX12, originally called arachidonate 12-lipoxygenase, was first characterized by the Nobel
Laureate,
189:
5959:
2460:
A selective but not totally specific inhibitor of ALOX12 reduced the growth response of cultured human
1323:
5727:
5717:
5552:
5198:
4783:
4646:
4620:
4022:
3969:
3534:
3007:
2775:
2401:
2389:
2377:
2054:
1723:
1416:
4128:"Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells"
1580:)-HETE and therefore is metabolically equivalent to ALOX12. For example, the functions inferred for
1340:
6097:
5923:
5244:
3906:
3805:
3769:
3632:
2360:
is a clustering of at least three of five of the following medical conditions: abdominal (central)
1783:
1663:
1318:
1148:
1101:
104:
5387:
3823:
3787:
5856:
5780:
5742:
5367:
4557:
4486:
4413:
4376:
4305:
4267:
3716:
2640:)-HETE in platelet function remains controversial and unclear; it is possible that the ALOX12-12(
2357:
2050:
149:
5221:
4990:
4970:
4965:
4955:
4935:
4920:
4910:
4719:
4689:
4664:
1152:
1127:
1097:
1076:
5397:
5340:
4995:
4930:
4925:
4915:
4814:
4809:
4804:
4729:
4709:
4684:
4674:
4669:
4659:
4654:
4636:
2632:
Although first identified in human platelets, the role of ALOX12 and its major metabolites, 12(
552:
5254:
5206:
5178:
5068:
5063:
4980:
4950:
4905:
4900:
4895:
4714:
4704:
4699:
4694:
4478:
4448:
4405:
4368:
4338:
4297:
4259:
4230:
4200:
4179:
4149:
4114:
4079:
4050:
3997:
3944:
3873:
3751:
3708:
3673:
3614:
3562:
3503:
3468:
3430:
3384:
3346:
3297:
3262:
3227:
3175:
3119:
3084:
3035:
2973:
2915:
2857:
2803:
2657:
2572:)-HETE by increasing their rate of proliferation, increasing their cell surface expression of
2553:
2489:
2176:
1747:
1407:
97:
45:
5392:
5163:
5005:
4975:
4724:
1718:
and at lower levels in the basal layer of the epidermis (particularly in the skin lesions of
1376:
5902:
5897:
5871:
5799:
5616:
5567:
5377:
5325:
5287:
5259:
5158:
5148:
5124:
4940:
4470:
4438:
4397:
4360:
4330:
4289:
4251:
4222:
4171:
4139:
4104:
4071:
4040:
4030:
3987:
3977:
3934:
3863:
3855:
3743:
3700:
3663:
3604:
3596:
3552:
3542:
3495:
3460:
3422:
3376:
3336:
3328:
3289:
3254:
3217:
3209:
3165:
3157:
3111:
3074:
3066:
3025:
3015:
2963:
2955:
2942:
Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, Nadler JL (January 2011).
2905:
2897:
2849:
2793:
2783:
2461:
1755:
1671:
394:
325:
269:
224:
145:
3521:
O'Flaherty JT, Hu Y, Wooten RE, Horita DA, Samuel MP, Thomas MJ, Sun H, Edwards IJ (2012).
3055:"Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes"
2996:"Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets"
2299:
preventing the development and complications of dietary-induced and/or genetically induced
1352:
5949:
5933:
5846:
2512:)-HETE in humans and may be a contributing factor for to essential hypertension (see also
2397:
2393:
2316:
2312:
1493:
1311:
369:
3317:"The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier"
2428:)-HETE, reactive oxygen species, and inflammation lead to fat cell dysfunction (also see
792:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
4026:
3973:
3538:
3011:
2779:
28:
5987:
5928:
5647:
5577:
5097:
5050:
5042:
5034:
4877:
4869:
4861:
4791:
4628:
4554:
4514:
3868:
3843:
3609:
3584:
3557:
3522:
3341:
3316:
3222:
3197:
3170:
3145:
3079:
3054:
2968:
2943:
2910:
2885:
2656:
gene has susceptibility alleles (rs6502997, rs312462, rs6502998, and rs434473) for the
2424:
and thereby types 1 and 2 diabetes and that in adipose tissue the excess in AlOX12, 12(
2196:
1675:
1451:
4334:
4317:
Tornhamre S, Elmqvist A, Lindgren JA (April 2000). "15-Lipoxygenation of leukotriene A
4109:
4092:
3939:
3922:
3030:
2995:
2853:
2798:
2763:
2620:
as screened in a yeast two-hybrid interaction library from human epidermoid carcinoma
1734:
The control of ALOX12 activity appears to rest principally on the availability of its
1431:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
680:
675:
670:
665:
660:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
594:
6086:
5892:
5851:
5547:
4401:
4075:
4045:
4010:
3992:
3957:
3258:
3115:
2661:
2369:
1679:
1561:
1426:
581:
4490:
4417:
4380:
4309:
4271:
4175:
3720:
2624:; these proteins are candidates for regulating 12-LOX, particularly in tumor cells.
2291:
Studies on rodents lacking or made deficient in the leukocyte-type 12-lipoxygenase,
1281:
which is located along with other lipoyxgenases on chromosome 17p13.3. ALOX12 is 75
5841:
5674:
5382:
5168:
4520:
4126:
Nakamura M, Ueda N, Kishimoto K, Yoshimoto T, Yamamoto S, Ishimura K (March 1995).
3923:"Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene"
2365:
2324:
2255:-eicosatetraenoic acid); both lipoxins are SPMs with many SPM-like activities (see
1935:
1739:
1615:
1573:
1267:
387:
166:
4091:
Wong PY, Westlund P, Hamberg M, Granström E, Chao PH, Samuelsson B (August 1985).
3585:"The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease"
3426:
2959:
2668:
bearer of these alleles thus suffer an increased susceptibility to this disease.
129:
3547:
3464:
3380:
3332:
3293:
3280:
Krieg P, Fürstenberger G (March 2014). "The role of lipoxygenases in epidermis".
3161:
1646:)-HpETE), a product with very different pathophysiological roles than that of 12(
153:
6065:
6000:
5836:
5562:
5211:
5000:
4945:
4551:
4321:: Studies of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation".
3499:
2884:
Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG (June 2015).
2749:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2731:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2541:
2191:)-HETE and the hepoxilins; it is a member of a class of PUFA metabolites termed
1435:
4509:
4015:
Proceedings of the
National Academy of Sciences of the United States of America
3962:
Proceedings of the
National Academy of Sciences of the United States of America
3600:
3213:
3000:
Proceedings of the
National Academy of Sciences of the United States of America
2768:
Proceedings of the
National Academy of Sciences of the United States of America
470:
5761:
5519:
5456:
5193:
4985:
4960:
4474:
2621:
1943:
1695:
1691:
1557:
1282:
286:
183:
133:
3245:
Nugteren DH (February 1975). "Arachidonate lipoxygenase in blood platelets".
6039:
6013:
5651:
5372:
5297:
5188:
5153:
4035:
3982:
2840:
Yamamoto S, Suzuki H, Ueda N (March 1997). "Arachidonate 12-lipoxygenases".
2613:
2577:
2573:
2421:
2280:
2034:-HETE promotes inflammation responses, may be involved in the perception of
1939:
1855:
1719:
1715:
1667:
906:
530:
408:
353:
340:
252:
239:
141:
4482:
4452:
4443:
4426:
4409:
4372:
4342:
4301:
4294:
10.1002/(SICI)1097-0215(19990909)82:6<827::AID-IJC10>3.0.CO;2-Q
4226:
3877:
3755:
3712:
3677:
3618:
3566:
3507:
3472:
3434:
3388:
3350:
3301:
3231:
3179:
3070:
3020:
2977:
2919:
2788:
4323:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
4263:
4255:
4234:
4204:
4183:
4153:
4118:
4083:
4054:
4001:
3948:
3668:
3651:
3369:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
3321:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
3282:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
3198:"12-lipoxygenase: a potential target for novel anti-platelet therapeutics"
3150:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
3123:
3088:
3039:
2861:
2807:
2295:(which is most closely related to human ALOX15) implicate this enzyme in:
1364:
1235:
1216:
1211:
5524:
5488:
5402:
5335:
5226:
5183:
4890:
4679:
4144:
4127:
3921:
Yoshimoto T, Arakawa T, Hada T, Yamamoto S, Takahashi E (December 1992).
3859:
3266:
2901:
2373:
2339:. In these studies, it is usually unclear which, if any metabolite(s) of
2323:
regulating blood vessel contraction, dilation, pressure, remodeling, and
2300:
1951:
1589:
1530:
1200:
1051:
1032:
1556:)-HpETE and to conduct this same metabolism on arachidonic acid that is
2605:
2589:
2513:
2433:
2429:
2417:
2405:
2361:
2304:
2256:
2172:
2039:
2035:
1954:
product by ubiquitous cellular peroxidase activities thereby forming 12
1854:
or possibly other, as yet not fully identified, hepoxilin syntheses to
1666:, and his famed colleague, Mats Hamberg, in 1974 by showing that human
1651:
1383:
1018:
973:
5235:
4364:
3747:
3704:
3315:
Muñoz-Garcia A, Thomas CP, Keeney DS, Zheng Y, Brash AR (March 2014).
2886:"Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes"
74:
6052:
5822:
5702:
5461:
5264:
5118:
2441:
1851:
1779:
1699:
1605:
1498:
1463:
1359:
1347:
1335:
1271:
1184:
928:
3650:
Quintana LF, Guzmán B, Collado S, Clària J, Poch E (February 2006).
2944:"Functional and pathological roles of the 12- and 15-lipoxygenases"
1714:, human ALOX12 is distributed predominantly in blood platelets and
6026:
3367:
Pace-Asciak CR (April 2015). "Pathophysiology of the hepoxilins".
2665:
2528:
or other forms of dementia have significantly higher levels of 12(
1600:)-HpETE but also makes lesser but still significant amounts of 12(
3247:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
891:
887:
3202:
Cardiovascular & Hematological Agents in Medicinal Chemistry
2617:
2585:
2544:) that produce Alzheimer's dementia-like syndromes implicate 12(
2331:
maintaining normal renal, neurological, and brain function; and
1711:
1371:
1278:
121:
108:, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
5795:
5620:
4524:
2187:
Maresin 1 has a set of activities that may oppose those of 12(
1738:(PUFA) substrates which are released from storage in membrane
1529:). Accordingly, rodent leukocyte 12-lipoxygenase is deemed an
867:
positive regulation of blood vessel endothelial cell migration
561:
3956:
Izumi T, Hoshiko S, Rådmark O, Samuelsson B (October 1990).
5791:
2762:
Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992).
4463:
European Archives of Psychiatry and Clinical Neuroscience
1540:
Human ALOX12 and ALOX15 along with rodent leukocyte-type
5079:
5016:
4843:
3146:"Mammalian lipoxygenases and their biological relevance"
377:
4064:
Prostaglandins, Leukotrienes, and Essential Fatty Acids
3488:
Prostaglandins, Leukotrienes, and Essential Fatty Acids
1686:
but also by a cyclooxygenase-independent pathway to 12(
852:
positive regulation of smooth muscle cell proliferation
707:
positive regulation of endothelial cell differentiation
5240:
Tooltip Arachidonate 5-lipoxygenase-activating protein
4829:
2183:
DHA → 17-hydroperoxy-DHA → 13,14-e-maresin → Maresin-1
1850:
HpETE may be further metabolized by ALOX12 itself, by
4498:
2271:-dihydroxyeicosatetraenoic acid (12,15-diHETE) and 15
872:
positive regulation of endothelial tube morphogenesis
542:
5413:
5313:
5275:
2472:(VEGF); this reduction was partially reversed by 12(
1898:-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid → 8
822:
positive regulation of cell population proliferation
752:
negative regulation of muscle cell apoptotic process
5978:
5942:
5911:
5880:
5829:
5770:
5751:
5663:
5537:
5502:
5470:
5438:
5411:
5349:
5311:
5273:
5136:
5134:
5117:
5077:
5014:
4841:
4827:
4738:
4595:
4581:
4564:
3583:Joshi YB, Giannopoulos PF, Praticò D (March 2015).
3362:
3360:
3104:
Biochemical and Biophysical Research Communications
1474:
1462:
1450:
1445:
1425:
1406:
1394:
1382:
1370:
1358:
1346:
1334:
1329:
1317:
1305:
1300:
1295:
1141:
1120:
1090:
1069:
812:
positive regulation of mitochondrial depolarization
2822:"Entrez Gene: ALOX12 arachidonate 12-lipoxygenase"
2705:
2703:
2701:
2684:
2682:
2680:
2109:)-docosahexaenoic acid)(i.e. 17-hydroperoxy-DHA)
1938:responses, increase pain perception (i.e. tactile
4740:
4597:
4425:Gu J, Wen Y, Mison A, Nadler JL (February 2003).
2764:"Characterization of human 12-lipoxygenase genes"
1758:(also termed as arachidonate or, chemically, as 5
777:positive regulation of endothelial cell migration
324:
223:
5504:
5472:
5351:
4193:Investigative Ophthalmology & Visual Science
3446:
3444:
2592:). These finding suggest that ALOX12 and its 12(
2404:of morbidly obese type 2 diabetic patients. The
1742:by cell stimulation. The enzyme participates in
1592:methods may not indicate a similar function for
5440:
4583:
4132:The Journal of Histochemistry and Cytochemistry
4009:Funk CD, Furci L, FitzGerald GA (August 1990).
3958:"Cloning of the cDNA for human 12-lipoxygenase"
2989:
2987:
2576:, increasing their survival and delaying their
2136:)-docosahexaenoic acid (i.e. 13,14-e-maresin)
16:Protein-coding gene in the species Homo sapiens
3144:Kuhn H, Banthiya S, van Leyen K (April 2015).
2937:
2935:
2933:
2931:
2929:
2710:GRCm38: Ensembl release 89: ENSMUSG00000000320
2430:12-HETE#Inflammation and inflammatory diseases
5807:
5632:
4536:
3578:
3576:
3408:
3406:
3404:
3402:
3400:
3398:
3191:
3189:
3053:Turner SR, Campbell JA, Lynn WS (June 1975).
2879:
2877:
2875:
2873:
2871:
2508:and elevation in the urinary excretion of 12(
2412:)-HETE product cause excessive production of
8:
3139:
3137:
3135:
3133:
2835:
2833:
2831:
2384:(HDL) levels. ALOX12 and its metabolite, 12(
2689:GRCh38: Ensembl release 89: ENSG00000108839
1710:Based predominantly on the presence of its
747:negative regulation of platelet aggregation
5814:
5800:
5792:
5639:
5625:
5617:
5573:5-HPETE (arachidonic acid 5-hydroperoxide)
5131:
4838:
4592:
4578:
4543:
4529:
4521:
2994:Hamberg M, Samuelsson B (September 1974).
2494:Endothelium-derived hyperpolarizing factor
1726:within the pancreas, and certain cancers.
1442:
902:
862:long-chain fatty acid biosynthetic process
577:
497:transitional epithelium of urinary bladder
365:
264:
161:
63:
4442:
4143:
4108:
4044:
4034:
3991:
3981:
3938:
3867:
3667:
3608:
3556:
3546:
3340:
3221:
3169:
3078:
3029:
3019:
2967:
2909:
2797:
2787:
2416:and inflammation which lead to losses in
2227:-eicosatetraenoic acid) and lipoxin B4 (5
767:reactive oxygen species metabolic process
5087:Tooltip Cysteinyl leukotriene receptor E
5024:Tooltip Cysteinyl leukotriene receptor 2
4851:Tooltip Cysteinyl leukotriene receptor 1
827:positive regulation of apoptotic process
742:negative regulation of apoptotic process
605:arachidonate 12(S)-lipoxygenase activity
4505:
2676:
2504:gene (R261Q ) has been associated with
1810:-hydroperoxyeicosatetraenoic acid or 12
4834:Tooltip Cysteinyl leukotriene receptor
2307:cell/tissue dysfunction, and obesity;
1292:
802:positive regulation of gene expression
18:
2580:, and increasing their production of
1285:protein composed of 663 amino acids.
727:positive regulation of cell migration
329:
290:
285:
228:
187:
182:
7:
5422:Tooltip Leukotriene B4 ω-hydroxylase
5318:Tooltip Arachidonate 15-lipoxygenase
5280:Tooltip Arachidonate 12-lipoxygenase
4093:"15-Lipoxygenase in human platelets"
3059:The Journal of Experimental Medicine
2492:and is therefore suggested to be an
2193:Specialized pro-resolution mediators
847:positive regulation of cell adhesion
615:hepoxilin-epoxide hydrolase activity
5733:4-Hydroxyphenylpyruvate dioxygenase
5141:Tooltip Arachidonate 5-lipoxygenase
4097:The Journal of Biological Chemistry
3927:The Journal of Biological Chemistry
762:positive regulation of angiogenesis
630:linoleate 13S-lipoxygenase activity
4164:The American Journal of Physiology
3589:Trends in Pharmacological Sciences
3196:Yeung J, Holinstat M (July 2011).
2582:vascular endothelial growth factor
2470:vascular endothelial growth factor
1138:
1117:
1087:
1066:
1042:
1023:
997:
978:
952:
933:
857:arachidonic acid metabolic process
797:positive regulation of cell growth
547:
465:
403:
382:
14:
5553:γ-Linolenic acid (gamolenic acid)
5207:Meclofenamic acid (meclofenamate)
4748:Tooltip Leukotriene B4 receptor 2
4605:Tooltip Leukotriene B4 receptor 1
2542:tau protein#Clinical significance
1950:-HpETE is rapidly reduced to its
1946:). Far more commonly, however, 12
1274:that in humans is encoded by the
702:positive regulation of cell death
5512:Tooltip Leukotriene D4 hydrolase
5481:Tooltip Leukotriene C4 hydrolase
5360:Tooltip Leukotriene A4 hydrolase
4508:
4402:10.1097/00008390-200209000-00003
3453:European Journal of Pharmacology
2139:This is further metabolized to 7
1874:-eicosatrienoic acid) and B3 (10
1684:12-hydroxyheptadecatrienoic acid
1576:that makes a predominance of 12(
1521:-eicosatetraenoic acid (i.e. 15(
807:leukotriene A4 metabolic process
551:
313:
306:
300:
277:
212:
205:
199:
174:
27:
5605:Prostanoid signaling modulators
5449:Tooltip Leukotriene C4 synthase
4588:Tooltip Leukotriene B4 receptor
4282:International Journal of Cancer
4176:10.1152/ajpcell.1994.266.1.C243
3844:"ALOX12 in human toxoplasmosis"
2400:as well as in the fat cells of
2370:elevated fasting plasma glucose
1976:12-hydroxyeicosatetraenoic acid
1934:Hepoxilins can promote certain
1806:-eicosatetraenoic acid (i.e. 12
1533:of ALOX15 and is designated as
1527:15-Hydroxyeicosatetraenoic acid
732:lipoxin B4 biosynthetic process
717:lipoxin A4 biosynthetic process
697:linoleic acid metabolic process
2466:basic fibroblast growth factor
2438:Single-nucleotide polymorphism
787:hepoxilin biosynthetic process
595:hepoxilin A3 synthase activity
562:More reference expression data
531:More reference expression data
1:
5723:Homogentisate 1,2-dioxygenase
5598:Receptor/signaling modulators
4353:Journal of Biomedical Science
4335:10.1016/S1388-1981(00)00017-2
4110:10.1016/S0021-9258(17)39346-8
3940:10.1016/S0021-9258(18)35835-6
3427:10.1016/j.jchromb.2014.03.015
2960:10.1016/j.plipres.2010.10.005
2854:10.1016/s0163-7827(97)00002-7
2081:)-docosahexaenoic acid to 14(
2042:). While arachidonate and 12(
1974:-eicosatetraenoic acid, i.e.
1774:-eicosatetraenoic acid) and O
712:establishment of skin barrier
298:
197:
6103:Enzymes of unknown structure
6093:Genes on human chromosome 17
5699:Arachidonate 15-lipoxygenase
5685:Arachidonate 12-lipoxygenase
4076:10.1016/0952-3278(88)90101-9
3548:10.1371/journal.pone.0045480
3465:10.1016/j.ejphar.2015.11.002
3381:10.1016/j.bbalip.2014.09.007
3333:10.1016/j.bbalip.2013.08.020
3294:10.1016/j.bbalip.2013.08.005
3259:10.1016/0005-2760(75)90016-8
3162:10.1016/j.bbalip.2014.10.002
3116:10.1016/0006-291X(90)91580-L
2608:). ALOX12 has been shown to
2388:)-HETE, are elevated in the
2171:-docosahexaenoic acid (i.e.
2006:)-eicosatetraenoic acid → 12
1746:by conducting the following
1296:arachidonate 12-lipoxygenase
1240:arachidonate 12-lipoxygenase
877:lipoxin biosynthetic process
757:fatty acid metabolic process
5738:Indoleamine 2,3-dioxygenase
5694:Arachidonate 8-lipoxygenase
5680:Arachidonate 5-lipoxygenase
3500:10.1016/j.plefa.2005.05.002
3415:Journal of Chromatography B
2440:, rs2073438, located in an
1744:arachidonic acid metabolism
1674:not only by the well-known
837:hepoxilin metabolic process
772:superoxide anion generation
6119:
4215:Experimental Cell Research
3905:gene details page in the
3601:10.1016/j.tips.2015.01.005
3214:10.2174/187152511797037619
2948:Progress in Lipid Research
2842:Progress in Lipid Research
2568:)-HETE, and respond to 12(
2436:). Indeed, in one study a
1736:polyunsaturated fatty acid
1642:-icosatetraenoic acid (12(
1584:in mice made deficient in
832:cellular response to lipid
5970:Michaelis–Menten kinetics
5708:Linoleate 11-lipoxygenase
5589:
4475:10.1007/s00406-003-0404-y
2745:"Mouse PubMed Reference:"
2727:"Human PubMed Reference:"
2538:Amyloid precursor protein
2498:single nucleotide variant
1914:-eicosatrienoic acid + 10
1564:; human ALOX15B makes 15(
1441:
1215:
1210:
1206:
1199:
1183:
1164:
1145:
1124:
1113:
1094:
1073:
1062:
1049:
1045:
1030:
1026:
1017:
1004:
1000:
985:
981:
972:
959:
955:
940:
936:
927:
912:
905:
901:
885:
842:lipoxin metabolic process
580:
576:
559:
550:
541:
528:
477:
468:
415:
406:
376:
368:
364:
347:
334:
297:
276:
267:
263:
246:
233:
196:
173:
164:
160:
115:
112:
102:
95:
90:
71:
66:
49:
44:
39:
35:
26:
21:
5862:Diffusion-limited enzyme
4244:Cell and Tissue Research
3693:Urologia Internationalis
2540:and/or tau protein (see
2382:high-density lipoprotein
2378:high serum triglycerides
1177:Chr 11: 70.13 – 70.15 Mb
5558:Dihomo-γ-linolenic acid
4036:10.1073/pnas.87.15.5638
3983:10.1073/pnas.87.19.7477
2890:Molecular Endocrinology
2590:12-HETE#prostate cancer
2519:
2414:reactive oxygen species
2366:elevated blood pressure
2175:1), by an unidentified
2026:)-eicosatetraenoic acid
1890:-eicosatrienoic acid):
635:oxidoreductase activity
431:epithelium of esophagus
4444:10.1210/en.2002-220580
4227:10.1006/excr.1996.0317
3848:Infection and Immunity
3071:10.1084/jem.141.6.1437
3021:10.1073/pnas.71.9.3400
2789:10.1073/pnas.89.9.3962
2514:12-HETE#Blood pressure
2506:essential hypertension
1918:-hydroxy-11,12-oxido-5
1902:-hydroxy-11,12-oxido-5
1878:-hydroxy-11,12-oxido-5
1862:-hydroxy-11,12-oxido-5
1842:-eicosatetraenoic acid
331:11 B3|11 42.99 cM
5955:Eadie–Hofstee diagram
5888:Allosteric regulation
5667:: two atoms of oxygen
5494:Serine-borate complex
4660:CGS-23131 (LY-223982)
4256:10.1007/s004410050818
3669:10.1038/sj.ki.5000147
2606:12-HETE#Other cancers
681:extracellular exosome
292:Chromosome 11 (mouse)
190:Chromosome 17 (human)
5965:Lineweaver–Burk plot
5755:: one atom of oxygen
5728:Cysteine dioxygenase
5718:Catechol dioxygenase
5430:17-Octadecynoic acid
5200:Hypericum perforatum
4145:10.1177/43.3.7868854
3899:genome location and
3860:10.1128/IAI.01505-13
3656:Kidney International
2902:10.1210/me.2015-1041
2402:white adipose tissue
2390:islets of Langerhans
2311:the development of
2055:docosahexaenoic acid
1930:-eicosatrienoic acid
1724:islets of Langerhans
817:fatty acid oxidation
782:lipoxygenase pathway
610:dioxygenase activity
67:List of PDB id codes
40:Available structures
5525:Ubenimex (bestatin)
5403:Ubenimex (bestatin)
4170:(1 Pt 1): C243-53.
4027:1990PNAS...87.5638F
3974:1990PNAS...87.7477I
3907:UCSC Genome Browser
3539:2012PLoSO...745480O
3012:1974PNAS...71.3400H
2780:1992PNAS...89.3962F
2660:, human congenital
2526:Alzheimer's disease
2520:Alzheimer's disease
2347:Preclinical studies
2337:Alzheimer's disease
2335:the development of
2049:It metabolizes the
1706:Tissue distribution
1664:Bengt I. Samuelsson
1568:)-HpETE but not 12(
1170:Chr 17: 7 – 7.01 Mb
501:submandibular gland
489:conjunctival fornix
5924:Enzyme superfamily
5857:Enzyme promiscuity
5781:Inositol oxygenase
5762:Firefly luciferase
5743:Chlorite dismutase
5715:other dioxygenase:
5293:3-Methoxytropolone
5217:N-Stearoyldopamine
2648:Other associations
2490:Potassium channels
2358:metabolic syndrome
2352:Metabolic syndrome
2051:omega-3 fatty acid
1007:ENSMUSG00000000320
690:Biological process
654:Cellular component
645:hydrolase activity
588:Molecular function
493:tibiofemoral joint
423:buccal mucosa cell
154:ALOX12 - orthologs
6080:
6079:
5789:
5788:
5614:
5613:
5533:
5532:
5202:(St. John's Wort)
5128:
5113:
5112:
5109:
5108:
4823:
4822:
4575:
4390:Melanoma Research
4365:10.1159/000048212
3748:10.1021/bi992664v
3705:10.1159/000446446
2658:parasitic disease
2628:Platelet function
2554:Alzheimer disease
2462:endothelial cells
2392:of patients with
2177:epoxide hydrolase
1748:chemical reaction
1730:Enzyme activities
1622:)-HpETE viz., 12(
1490:
1489:
1486:
1485:
1389:metabolic pathway
1238:), also known as
1226:
1225:
1222:
1221:
1195:
1194:
1160:
1159:
1135:
1134:
1109:
1108:
1084:
1083:
1058:
1057:
1039:
1038:
1013:
1012:
994:
993:
968:
967:
949:
948:
897:
896:
620:metal ion binding
572:
571:
568:
567:
537:
536:
524:
523:
462:
461:
360:
359:
259:
258:
86:
85:
82:
81:
50:Ortholog search:
6110:
5960:Hanes–Woolf plot
5903:Enzyme activator
5898:Enzyme inhibitor
5872:Enzyme catalysis
5816:
5809:
5802:
5793:
5641:
5634:
5627:
5618:
5568:Arachidonic acid
5513:
5509:
5482:
5478:
5450:
5446:
5423:
5419:
5361:
5357:
5319:
5315:
5281:
5277:
5241:
5237:
5142:
5138:
5132:
5122:
5088:
5084:
5025:
5021:
4852:
4848:
4839:
4835:
4831:
4749:
4745:
4606:
4602:
4593:
4589:
4585:
4579:
4569:
4545:
4538:
4531:
4522:
4513:
4512:
4504:
4494:
4456:
4446:
4421:
4384:
4346:
4329:(2–3): 298–306.
4313:
4275:
4238:
4208:
4187:
4157:
4147:
4122:
4112:
4087:
4058:
4048:
4038:
4005:
3995:
3985:
3952:
3942:
3882:
3881:
3871:
3838:
3832:
3831:
3820:
3814:
3813:
3802:
3796:
3795:
3784:
3778:
3777:
3766:
3760:
3759:
3731:
3725:
3724:
3688:
3682:
3681:
3671:
3647:
3641:
3640:
3629:
3623:
3622:
3612:
3580:
3571:
3570:
3560:
3550:
3518:
3512:
3511:
3483:
3477:
3476:
3448:
3439:
3438:
3410:
3393:
3392:
3364:
3355:
3354:
3344:
3312:
3306:
3305:
3277:
3271:
3270:
3242:
3236:
3235:
3225:
3193:
3184:
3183:
3173:
3141:
3128:
3127:
3099:
3093:
3092:
3082:
3050:
3044:
3043:
3033:
3023:
2991:
2982:
2981:
2971:
2939:
2924:
2923:
2913:
2881:
2866:
2865:
2837:
2826:
2825:
2818:
2812:
2811:
2801:
2791:
2759:
2753:
2752:
2741:
2735:
2734:
2723:
2717:
2707:
2696:
2686:
2434:12-HETE#Diabetes
2343:was implicated.
2085:)-hydroperoxy-4(
1818:arachidonate + O
1756:arachidonic acid
1672:arachidonic acid
1494:systematic names
1443:
1293:
1208:
1207:
1179:
1172:
1155:
1139:
1130:
1118:
1114:RefSeq (protein)
1104:
1088:
1079:
1067:
1043:
1024:
998:
979:
953:
934:
903:
722:lipid metabolism
600:iron ion binding
578:
564:
555:
548:
533:
513:seminal vesicula
485:efferent ductule
473:
471:Top expressed in
466:
411:
409:Top expressed in
404:
383:
366:
356:
343:
332:
317:
310:
304:
293:
281:
265:
255:
242:
231:
216:
209:
203:
192:
178:
162:
156:
107:
100:
77:
64:
58:
37:
36:
31:
19:
6118:
6117:
6113:
6112:
6111:
6109:
6108:
6107:
6083:
6082:
6081:
6076:
5988:Oxidoreductases
5974:
5950:Enzyme kinetics
5938:
5934:List of enzymes
5907:
5876:
5847:Catalytic triad
5825:
5820:
5790:
5785:
5766:
5747:
5659:
5648:Oxidoreductases
5645:
5615:
5610:
5585:
5581:
5529:
5511:
5508:
5498:
5480:
5476:
5466:
5448:
5444:
5434:
5421:
5417:
5407:
5359:
5355:
5345:
5317:
5307:
5279:
5269:
5239:
5140:
5121:
5105:
5101:
5086:
5083:
5073:
5054:
5046:
5038:
5023:
5020:
5010:
4881:
4873:
4865:
4850:
4847:
4833:
4819:
4795:
4787:
4747:
4744:
4734:
4650:
4632:
4624:
4604:
4601:
4587:
4568:
4560:
4549:
4519:
4507:
4499:
4497:
4459:
4424:
4387:
4349:
4320:
4316:
4278:
4241:
4211:
4190:
4160:
4125:
4090:
4061:
4021:(15): 5638–42.
4008:
3968:(19): 7477–81.
3955:
3933:(34): 24805–9.
3920:
3916:
3914:Further reading
3890:
3885:
3840:
3839:
3835:
3822:
3821:
3817:
3804:
3803:
3799:
3786:
3785:
3781:
3768:
3767:
3763:
3742:(12): 3185–91.
3733:
3732:
3728:
3690:
3689:
3685:
3649:
3648:
3644:
3631:
3630:
3626:
3582:
3581:
3574:
3520:
3519:
3515:
3494:(3–4): 141–62.
3485:
3484:
3480:
3450:
3449:
3442:
3412:
3411:
3396:
3366:
3365:
3358:
3314:
3313:
3309:
3279:
3278:
3274:
3244:
3243:
3239:
3195:
3194:
3187:
3143:
3142:
3131:
3101:
3100:
3096:
3052:
3051:
3047:
2993:
2992:
2985:
2941:
2940:
2927:
2883:
2882:
2869:
2839:
2838:
2829:
2820:
2819:
2815:
2761:
2760:
2756:
2743:
2742:
2738:
2725:
2724:
2720:
2708:
2699:
2687:
2678:
2674:
2650:
2636:)-HpETE and 12(
2630:
2562:
2532:)-HETE (and 15(
2522:
2458:
2398:type 2 diabetes
2394:type 1 diabetes
2354:
2349:
2317:Steatohepatitis
2313:atherosclerosis
2289:
1990:-hydroperoxy-5(
1821:
1777:
1732:
1708:
1660:
1626:)-hydroperoxy-5
1552:)-HpETE and 15(
1505:)-hydroperoxy-5
1291:
1244:12-lipoxygenase
1217:View/Edit Mouse
1212:View/Edit Human
1175:
1168:
1165:Location (UCSC)
1151:
1147:
1126:
1100:
1096:
1075:
988:ENSG00000108839
881:
685:
649:
625:protein binding
560:
529:
520:
515:
511:
507:
503:
499:
495:
491:
487:
483:
469:
458:
453:
451:skin of abdomen
449:
445:
441:
437:
433:
429:
425:
421:
407:
351:
338:
330:
320:
319:
318:
311:
291:
268:Gene location (
250:
237:
229:
219:
218:
217:
210:
188:
165:Gene location (
116:
103:
96:
73:
51:
17:
12:
11:
5:
6116:
6114:
6106:
6105:
6100:
6095:
6085:
6084:
6078:
6077:
6075:
6074:
6061:
6048:
6035:
6022:
6009:
5996:
5982:
5980:
5976:
5975:
5973:
5972:
5967:
5962:
5957:
5952:
5946:
5944:
5940:
5939:
5937:
5936:
5931:
5926:
5921:
5915:
5913:
5912:Classification
5909:
5908:
5906:
5905:
5900:
5895:
5890:
5884:
5882:
5878:
5877:
5875:
5874:
5869:
5864:
5859:
5854:
5849:
5844:
5839:
5833:
5831:
5827:
5826:
5821:
5819:
5818:
5811:
5804:
5796:
5787:
5786:
5784:
5783:
5777:
5775:
5768:
5767:
5765:
5764:
5758:
5756:
5749:
5748:
5746:
5745:
5740:
5735:
5730:
5725:
5720:
5711:
5710:
5705:
5696:
5691:
5682:
5670:
5668:
5661:
5660:
5652:monooxygenases
5646:
5644:
5643:
5636:
5629:
5621:
5612:
5611:
5609:
5608:
5601:
5594:
5590:
5587:
5586:
5584:
5583:
5579:
5575:
5570:
5565:
5563:Diacylglycerol
5560:
5555:
5550:
5541:
5539:
5535:
5534:
5531:
5530:
5528:
5527:
5522:
5516:
5514:
5506:
5500:
5499:
5497:
5496:
5491:
5485:
5483:
5474:
5468:
5467:
5465:
5464:
5459:
5453:
5451:
5442:
5436:
5435:
5433:
5432:
5426:
5424:
5415:
5409:
5408:
5406:
5405:
5400:
5395:
5390:
5385:
5380:
5375:
5370:
5364:
5362:
5353:
5347:
5346:
5344:
5343:
5338:
5333:
5328:
5322:
5320:
5309:
5308:
5306:
5305:
5300:
5295:
5290:
5284:
5282:
5271:
5270:
5268:
5267:
5262:
5257:
5252:
5247:
5230:
5229:
5224:
5219:
5214:
5209:
5204:
5196:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5145:
5143:
5129:
5115:
5114:
5111:
5110:
5107:
5106:
5104:
5103:
5099:
5091:
5089:
5081:
5075:
5074:
5072:
5071:
5066:
5057:
5056:
5052:
5048:
5044:
5040:
5036:
5028:
5026:
5018:
5012:
5011:
5009:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4884:
4883:
4879:
4875:
4871:
4867:
4863:
4855:
4853:
4845:
4836:
4825:
4824:
4821:
4820:
4818:
4817:
4812:
4807:
4798:
4797:
4793:
4789:
4785:
4784:20-Hydroxy-LTB
4781:
4776:
4771:
4766:
4761:
4752:
4750:
4742:
4736:
4735:
4733:
4732:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4648:
4647:20-Carboxy-LTB
4640:
4639:
4634:
4630:
4626:
4622:
4621:20-Hydroxy-LTB
4618:
4609:
4607:
4599:
4590:
4576:
4562:
4561:
4550:
4548:
4547:
4540:
4533:
4525:
4518:
4517:
4496:
4495:
4457:
4422:
4385:
4347:
4318:
4314:
4276:
4239:
4221:(2): 197–205.
4209:
4188:
4158:
4123:
4103:(16): 9162–5.
4088:
4059:
4006:
3953:
3917:
3915:
3912:
3911:
3910:
3889:
3888:External links
3886:
3884:
3883:
3833:
3815:
3797:
3779:
3761:
3726:
3683:
3642:
3624:
3572:
3513:
3478:
3440:
3394:
3356:
3307:
3288:(3): 390–400.
3272:
3253:(2): 299–307.
3237:
3185:
3129:
3094:
3065:(6): 1437–41.
3045:
2983:
2925:
2896:(6): 791–800.
2867:
2827:
2813:
2754:
2736:
2718:
2697:
2675:
2673:
2670:
2649:
2646:
2629:
2626:
2561:
2558:
2524:Patients with
2521:
2518:
2457:
2454:
2444:region of the
2353:
2350:
2348:
2345:
2288:
2287:Animal studies
2285:
2275:-HETE to 14,15
2197:leukotriene A4
2185:
2184:
2179:-type enzyme:
2028:
2027:
1932:
1931:
1844:
1843:
1826:-hydroperoxy-5
1819:
1790:-hydroperoxy-5
1775:
1731:
1728:
1707:
1704:
1680:prostaglandins
1676:cyclooxygenase
1659:
1656:
1488:
1487:
1484:
1483:
1478:
1472:
1471:
1466:
1460:
1459:
1454:
1448:
1447:
1439:
1438:
1429:
1423:
1422:
1411:
1404:
1403:
1398:
1392:
1391:
1386:
1380:
1379:
1374:
1368:
1367:
1362:
1356:
1355:
1350:
1344:
1343:
1338:
1332:
1331:
1327:
1326:
1321:
1315:
1314:
1309:
1303:
1302:
1298:
1297:
1290:
1287:
1224:
1223:
1220:
1219:
1214:
1204:
1203:
1197:
1196:
1193:
1192:
1190:
1188:
1181:
1180:
1173:
1166:
1162:
1161:
1158:
1157:
1143:
1142:
1136:
1133:
1132:
1122:
1121:
1115:
1111:
1110:
1107:
1106:
1092:
1091:
1085:
1082:
1081:
1071:
1070:
1064:
1060:
1059:
1056:
1055:
1047:
1046:
1040:
1037:
1036:
1028:
1027:
1021:
1015:
1014:
1011:
1010:
1002:
1001:
995:
992:
991:
983:
982:
976:
970:
969:
966:
965:
957:
956:
950:
947:
946:
938:
937:
931:
925:
924:
919:
914:
910:
909:
899:
898:
895:
894:
883:
882:
880:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
657:
655:
651:
650:
648:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
591:
589:
585:
584:
574:
573:
570:
569:
566:
565:
557:
556:
545:
539:
538:
535:
534:
526:
525:
522:
521:
519:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
475:
474:
463:
460:
459:
457:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:amniotic fluid
416:
413:
412:
400:
399:
391:
380:
374:
373:
370:RNA expression
362:
361:
358:
357:
349:
345:
344:
336:
333:
328:
322:
321:
312:
305:
299:
295:
294:
289:
283:
282:
274:
273:
261:
260:
257:
256:
248:
244:
243:
235:
232:
227:
221:
220:
211:
204:
198:
194:
193:
186:
180:
179:
171:
170:
158:
157:
114:
110:
109:
101:
93:
92:
88:
87:
84:
83:
80:
79:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
6115:
6104:
6101:
6099:
6096:
6094:
6091:
6090:
6088:
6072:
6068:
6067:
6062:
6059:
6055:
6054:
6049:
6046:
6042:
6041:
6036:
6033:
6029:
6028:
6023:
6020:
6016:
6015:
6010:
6007:
6003:
6002:
5997:
5994:
5990:
5989:
5984:
5983:
5981:
5977:
5971:
5968:
5966:
5963:
5961:
5958:
5956:
5953:
5951:
5948:
5947:
5945:
5941:
5935:
5932:
5930:
5929:Enzyme family
5927:
5925:
5922:
5920:
5917:
5916:
5914:
5910:
5904:
5901:
5899:
5896:
5894:
5893:Cooperativity
5891:
5889:
5886:
5885:
5883:
5879:
5873:
5870:
5868:
5865:
5863:
5860:
5858:
5855:
5853:
5852:Oxyanion hole
5850:
5848:
5845:
5843:
5840:
5838:
5835:
5834:
5832:
5828:
5824:
5817:
5812:
5810:
5805:
5803:
5798:
5797:
5794:
5782:
5779:
5778:
5776:
5773:
5769:
5763:
5760:
5759:
5757:
5754:
5750:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5716:
5713:
5712:
5709:
5706:
5704:
5700:
5697:
5695:
5692:
5690:
5686:
5683:
5681:
5678:
5676:
5672:
5671:
5669:
5666:
5662:
5657:
5653:
5649:
5642:
5637:
5635:
5630:
5628:
5623:
5622:
5619:
5607:
5606:
5602:
5600:
5599:
5595:
5592:
5591:
5588:
5582:
5578:Leukotriene A
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5548:Linoleic acid
5546:
5543:
5542:
5540:
5536:
5526:
5523:
5521:
5518:
5517:
5515:
5510:
5501:
5495:
5492:
5490:
5487:
5486:
5484:
5479:
5469:
5463:
5460:
5458:
5455:
5454:
5452:
5447:
5437:
5431:
5428:
5427:
5425:
5420:
5410:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5374:
5371:
5369:
5366:
5365:
5363:
5358:
5348:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5323:
5321:
5316:
5310:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5285:
5283:
5278:
5272:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5238:
5232:
5231:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5201:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5146:
5144:
5139:
5133:
5130:
5126:
5120:
5116:
5102:
5098:Leukotriene E
5096:
5093:
5092:
5090:
5085:
5076:
5070:
5067:
5065:
5062:
5059:
5058:
5055:
5051:Leukotriene E
5049:
5047:
5043:Leukotriene D
5041:
5039:
5035:Leukotriene C
5033:
5030:
5029:
5027:
5022:
5013:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4886:
4885:
4882:
4878:Leukotriene E
4876:
4874:
4870:Leukotriene D
4868:
4866:
4862:Leukotriene C
4860:
4857:
4856:
4854:
4849:
4840:
4837:
4832:
4826:
4816:
4813:
4811:
4808:
4806:
4803:
4800:
4799:
4796:
4792:Leukotriene B
4790:
4788:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4754:
4753:
4751:
4746:
4737:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4645:
4642:
4641:
4638:
4635:
4633:
4629:Leukotriene B
4627:
4625:
4619:
4617:
4614:
4611:
4610:
4608:
4603:
4594:
4591:
4586:
4580:
4577:
4573:
4567:
4563:
4559:
4556:
4553:
4546:
4541:
4539:
4534:
4532:
4527:
4526:
4523:
4516:
4511:
4506:
4502:
4492:
4488:
4484:
4480:
4476:
4472:
4468:
4464:
4458:
4454:
4450:
4445:
4440:
4437:(2): 534–43.
4436:
4432:
4431:Endocrinology
4428:
4423:
4419:
4415:
4411:
4407:
4403:
4399:
4396:(5): 429–34.
4395:
4391:
4386:
4382:
4378:
4374:
4370:
4366:
4362:
4359:(2): 156–65.
4358:
4354:
4348:
4344:
4340:
4336:
4332:
4328:
4324:
4315:
4311:
4307:
4303:
4299:
4295:
4291:
4288:(6): 827–31.
4287:
4283:
4277:
4273:
4269:
4265:
4261:
4257:
4253:
4250:(2): 327–34.
4249:
4245:
4240:
4236:
4232:
4228:
4224:
4220:
4216:
4210:
4206:
4202:
4199:(7): 1411–8.
4198:
4194:
4189:
4185:
4181:
4177:
4173:
4169:
4165:
4159:
4155:
4151:
4146:
4141:
4138:(3): 237–44.
4137:
4133:
4129:
4124:
4120:
4116:
4111:
4106:
4102:
4098:
4094:
4089:
4085:
4081:
4077:
4073:
4069:
4065:
4060:
4056:
4052:
4047:
4042:
4037:
4032:
4028:
4024:
4020:
4016:
4012:
4007:
4003:
3999:
3994:
3989:
3984:
3979:
3975:
3971:
3967:
3963:
3959:
3954:
3950:
3946:
3941:
3936:
3932:
3928:
3924:
3919:
3918:
3913:
3908:
3904:
3903:
3898:
3897:
3892:
3891:
3887:
3879:
3875:
3870:
3865:
3861:
3857:
3854:(7): 2670–9.
3853:
3849:
3845:
3837:
3834:
3829:
3825:
3819:
3816:
3811:
3807:
3801:
3798:
3793:
3789:
3783:
3780:
3775:
3771:
3765:
3762:
3757:
3753:
3749:
3745:
3741:
3737:
3730:
3727:
3722:
3718:
3714:
3710:
3706:
3702:
3698:
3694:
3687:
3684:
3679:
3675:
3670:
3665:
3662:(3): 526–30.
3661:
3657:
3653:
3646:
3643:
3638:
3634:
3628:
3625:
3620:
3616:
3611:
3606:
3602:
3598:
3594:
3590:
3586:
3579:
3577:
3573:
3568:
3564:
3559:
3554:
3549:
3544:
3540:
3536:
3533:(9): e45480.
3532:
3528:
3524:
3517:
3514:
3509:
3505:
3501:
3497:
3493:
3489:
3482:
3479:
3474:
3470:
3466:
3462:
3458:
3454:
3447:
3445:
3441:
3436:
3432:
3428:
3424:
3420:
3416:
3409:
3407:
3405:
3403:
3401:
3399:
3395:
3390:
3386:
3382:
3378:
3375:(4): 383–96.
3374:
3370:
3363:
3361:
3357:
3352:
3348:
3343:
3338:
3334:
3330:
3326:
3322:
3318:
3311:
3308:
3303:
3299:
3295:
3291:
3287:
3283:
3276:
3273:
3268:
3264:
3260:
3256:
3252:
3248:
3241:
3238:
3233:
3229:
3224:
3219:
3215:
3211:
3208:(3): 154–64.
3207:
3203:
3199:
3192:
3190:
3186:
3181:
3177:
3172:
3167:
3163:
3159:
3156:(4): 308–30.
3155:
3151:
3147:
3140:
3138:
3136:
3134:
3130:
3125:
3121:
3117:
3113:
3110:(3): 1230–5.
3109:
3105:
3098:
3095:
3090:
3086:
3081:
3076:
3072:
3068:
3064:
3060:
3056:
3049:
3046:
3041:
3037:
3032:
3027:
3022:
3017:
3013:
3009:
3006:(9): 3400–4.
3005:
3001:
2997:
2990:
2988:
2984:
2979:
2975:
2970:
2965:
2961:
2957:
2954:(1): 115–31.
2953:
2949:
2945:
2938:
2936:
2934:
2932:
2930:
2926:
2921:
2917:
2912:
2907:
2903:
2899:
2895:
2891:
2887:
2880:
2878:
2876:
2874:
2872:
2868:
2863:
2859:
2855:
2851:
2847:
2843:
2836:
2834:
2832:
2828:
2823:
2817:
2814:
2809:
2805:
2800:
2795:
2790:
2785:
2781:
2777:
2774:(9): 3962–6.
2773:
2769:
2765:
2758:
2755:
2750:
2746:
2740:
2737:
2732:
2728:
2722:
2719:
2715:
2711:
2706:
2704:
2702:
2698:
2694:
2690:
2685:
2683:
2681:
2677:
2671:
2669:
2667:
2663:
2662:toxoplasmosis
2659:
2655:
2647:
2645:
2643:
2639:
2635:
2627:
2625:
2623:
2619:
2615:
2611:
2607:
2603:
2599:
2595:
2591:
2587:
2583:
2579:
2575:
2571:
2567:
2559:
2557:
2555:
2551:
2547:
2543:
2539:
2535:
2531:
2527:
2517:
2515:
2511:
2507:
2503:
2499:
2496:. Finally, a
2495:
2491:
2487:
2483:
2479:
2475:
2471:
2467:
2463:
2456:Blood vessels
2455:
2453:
2451:
2447:
2443:
2439:
2435:
2431:
2427:
2423:
2419:
2415:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2383:
2379:
2375:
2371:
2367:
2363:
2359:
2351:
2346:
2344:
2342:
2338:
2334:
2330:
2326:
2322:
2318:
2314:
2310:
2306:
2302:
2298:
2294:
2286:
2284:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2239:-trihydroxy-6
2238:
2234:
2230:
2226:
2222:
2218:
2214:
2211:-trihydroxy-7
2210:
2206:
2202:
2198:
2194:
2190:
2182:
2181:
2180:
2178:
2174:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2142:
2137:
2135:
2131:
2127:
2123:
2119:
2115:
2110:
2108:
2104:
2100:
2096:
2092:
2088:
2084:
2080:
2076:
2072:
2068:
2064:
2060:
2057:(DHA i.e., 4(
2056:
2052:
2047:
2045:
2041:
2037:
2033:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1989:
1985:
1984:
1983:
1981:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1901:
1897:
1893:
1892:
1891:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1841:
1837:
1833:
1829:
1825:
1817:
1816:
1815:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1773:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1740:phospholipids
1737:
1729:
1727:
1725:
1721:
1717:
1713:
1705:
1703:
1701:
1697:
1693:
1689:
1685:
1681:
1678:pathway into
1677:
1673:
1669:
1665:
1657:
1655:
1653:
1650:)-HpETE (see
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1617:
1614:
1609:
1607:
1604:)-HpETE (see
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1562:phospholipids
1559:
1555:
1551:
1547:
1543:
1538:
1536:
1532:
1528:
1525:)-HpETE; see
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1495:
1482:
1479:
1477:
1473:
1470:
1467:
1465:
1461:
1458:
1455:
1453:
1449:
1444:
1440:
1437:
1433:
1430:
1428:
1427:Gene Ontology
1424:
1421:
1418:
1415:
1412:
1409:
1405:
1402:
1399:
1397:
1393:
1390:
1387:
1385:
1381:
1378:
1375:
1373:
1369:
1366:
1365:NiceZyme view
1363:
1361:
1357:
1354:
1351:
1349:
1345:
1342:
1339:
1337:
1333:
1328:
1325:
1322:
1320:
1316:
1313:
1310:
1308:
1304:
1299:
1294:
1288:
1286:
1284:
1280:
1277:
1273:
1269:
1265:
1263:
1257:
1253:
1252:-Lipoxygenase
1251:
1245:
1241:
1237:
1234:
1230:
1218:
1213:
1209:
1205:
1202:
1198:
1191:
1189:
1186:
1182:
1178:
1174:
1171:
1167:
1163:
1156:
1154:
1150:
1144:
1140:
1137:
1131:
1129:
1123:
1119:
1116:
1112:
1105:
1103:
1099:
1093:
1089:
1086:
1080:
1078:
1072:
1068:
1065:
1063:RefSeq (mRNA)
1061:
1054:
1053:
1048:
1044:
1041:
1035:
1034:
1029:
1025:
1022:
1020:
1016:
1009:
1008:
1003:
999:
996:
990:
989:
984:
980:
977:
975:
971:
964:
963:
958:
954:
951:
945:
944:
939:
935:
932:
930:
926:
923:
920:
918:
915:
911:
908:
904:
900:
893:
889:
884:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
694:
692:
689:
688:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
658:
656:
653:
652:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
583:
582:Gene ontology
579:
575:
563:
558:
554:
549:
546:
544:
540:
532:
527:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
479:
476:
472:
467:
464:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:
414:
410:
405:
402:
401:
398:
396:
392:
390:
389:
385:
384:
381:
379:
375:
371:
367:
363:
355:
350:
346:
342:
337:
327:
323:
316:
309:
303:
296:
288:
284:
280:
275:
271:
266:
262:
254:
249:
245:
241:
236:
226:
222:
215:
208:
202:
195:
191:
185:
181:
177:
172:
168:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
111:
106:
99:
94:
89:
78:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
6066:Translocases
6063:
6050:
6037:
6024:
6011:
6001:Transferases
5998:
5985:
5842:Binding site
5714:
5688:
5675:lipoxygenase
5673:
5603:
5596:
5544:
5388:JNJ-26993135
5383:Fosinoprilat
5233:
5199:
5169:Caffeic acid
5094:
5061:Antagonists:
5060:
5031:
4888:Antagonists:
4887:
4858:
4802:Antagonists:
4801:
4755:
4644:Antagonists:
4643:
4612:
4466:
4462:
4434:
4430:
4393:
4389:
4356:
4352:
4326:
4322:
4285:
4281:
4247:
4243:
4218:
4214:
4196:
4192:
4167:
4163:
4135:
4131:
4100:
4096:
4070:(2): 87–94.
4067:
4063:
4018:
4014:
3965:
3961:
3930:
3926:
3901:
3895:
3851:
3847:
3836:
3827:
3818:
3809:
3800:
3791:
3782:
3773:
3764:
3739:
3736:Biochemistry
3735:
3729:
3699:(1): 16–25.
3696:
3692:
3686:
3659:
3655:
3645:
3636:
3627:
3595:(3): 181–6.
3592:
3588:
3530:
3526:
3516:
3491:
3487:
3481:
3456:
3452:
3418:
3414:
3372:
3368:
3327:(3): 401–8.
3324:
3320:
3310:
3285:
3281:
3275:
3250:
3246:
3240:
3205:
3201:
3153:
3149:
3107:
3103:
3097:
3062:
3058:
3048:
3003:
2999:
2951:
2947:
2893:
2889:
2848:(1): 23–41.
2845:
2841:
2816:
2771:
2767:
2757:
2748:
2739:
2730:
2721:
2653:
2651:
2641:
2637:
2633:
2631:
2601:
2597:
2593:
2569:
2565:
2563:
2549:
2545:
2533:
2529:
2523:
2509:
2501:
2485:
2481:
2477:
2473:
2459:
2449:
2445:
2425:
2409:
2385:
2355:
2340:
2332:
2328:
2325:angiogenesis
2320:
2308:
2296:
2292:
2290:
2276:
2272:
2268:
2264:
2260:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2212:
2208:
2204:
2200:
2192:
2188:
2186:
2168:
2164:
2160:
2156:
2152:
2148:
2147:-dihydroxy-4
2144:
2140:
2138:
2133:
2129:
2125:
2121:
2117:
2113:
2111:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2048:
2043:
2031:
2029:
2023:
2019:
2015:
2011:
2007:
2003:
1999:
1995:
1991:
1987:
1979:
1971:
1967:
1963:
1959:
1955:
1947:
1936:inflammation
1933:
1927:
1923:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1859:
1847:
1846:In cells, 12
1845:
1839:
1835:
1831:
1827:
1823:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1771:
1767:
1763:
1759:
1750:wherein its
1733:
1709:
1687:
1661:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1616:stereoisomer
1612:
1610:
1601:
1597:
1593:
1585:
1581:
1577:
1574:lipoxygenase
1569:
1565:
1560:to membrane
1553:
1549:
1545:
1541:
1539:
1534:
1522:
1518:
1514:
1510:
1506:
1502:
1491:
1353:BRENDA entry
1289:Nomenclature
1275:
1268:lipoxygenase
1261:
1259:
1255:
1249:
1247:
1243:
1239:
1228:
1227:
1149:NP_001318047
1146:
1125:
1102:NM_001331118
1095:
1074:
1050:
1031:
1005:
986:
960:
941:
921:
916:
737:human ageing
393:
386:
113:External IDs
72:
5837:Active site
5545:Precursors:
5368:Acebilustat
5242:inhibitors:
5212:Minocycline
5001:Zafirlukast
4946:Montelukast
4552:Leukotriene
4469:(1): 40–3.
3806:"rs6502998"
3770:"rs6502997"
3633:"rs2073438"
3459:: 108–115.
2548:)-HETE, 15(
2476:)-HETE; 12(
2420:-secreting
2263:)-HETE to 5
2010:-hydroxy-5(
1696:neutrophils
1670:metabolize
1341:IntEnz view
1324:82391-43-3
1301:Identifiers
505:ankle joint
455:skin of leg
447:oral cavity
352:70,146,179
339:70,132,283
91:Identifiers
6098:EC 1.13.11
6087:Categories
6040:Isomerases
6014:Hydrolases
5881:Regulation
5520:Cilastatin
5457:Azelastine
5222:Timegadine
5194:Hyperforin
5125:inhibitors
4991:Tomelukast
4986:Tipelukast
4971:SKF-104353
4966:Ritolukast
4961:Pranlukast
4956:Pobilukast
4936:Masilukast
4921:ICI-198615
4911:Cinalukast
4720:Ticolubant
4690:Moxilubant
4665:CGS-25019C
4558:modulators
3828:NCBI dbSNP
3824:"rs434473"
3810:NCBI dbSNP
3792:NCBI dbSNP
3788:"rs312462"
3774:NCBI dbSNP
3637:NCBI dbSNP
2716:, May 2017
2695:, May 2017
2672:References
2622:A431 cells
2422:beta cells
2380:, and low
2372:(or overt
1958:-hydroxy-5
1944:Hepoxilins
1782:) and its
1752:substrates
1716:leukocytes
1692:chemotaxis
1558:esterified
1410:structures
1377:KEGG entry
1312:1.13.11.31
1283:kilodalton
1236:1.13.11.31
676:sarcolemma
397:(ortholog)
251:7,010,754
238:6,996,049
134:HomoloGene
5919:EC number
5398:SC-57461A
5373:Captopril
5341:PD-146176
5298:Baicalein
5189:Fenleuton
5154:Baicalein
5095:Agonists:
5032:Agonists:
4996:Verlukast
4931:LY-170680
4926:Iralukast
4916:FPL-55712
4859:Agonists:
4815:ZK-158252
4810:LY-255283
4805:CP-195543
4756:Agonists:
4730:ZK-158252
4710:SB-209247
4685:LY-293111
4675:CP-195543
4670:CP-105696
4655:Amelubant
4637:LY-255283
4613:Agonists:
4555:signaling
3421:: 26–40.
2614:Keratin 5
2578:apoptosis
2574:integrins
2281:apoptosis
1940:allodynia
1856:hepoxilin
1814:-HpETE):
1720:psoriasis
1694:of human
1668:platelets
1658:Discovery
1330:Databases
1153:NP_031466
1128:NP_000688
1098:NM_007440
1077:NM_000697
907:Orthologs
661:cytoplasm
142:GeneCards
5943:Kinetics
5867:Cofactor
5830:Activity
5593:See also
5489:Acivicin
5336:Luteolin
5255:BAYx1005
5227:Zileuton
5184:Curcumin
5179:CJ-13610
5069:BAYu9916
5064:BAYu9773
4981:Sulukast
4951:ONO-1078
4906:BAYx7195
4901:BAYu9916
4896:BAYu9773
4891:Ablukast
4779:15-HpETE
4769:12-HpETE
4715:SC-53228
4705:RP-69698
4700:RG-14893
4695:ONO-4057
4680:Etalocib
4566:Receptor
4491:21064663
4483:12664313
4453:12538614
4418:27336312
4410:12394183
4381:46753449
4373:11914583
4343:10760478
4310:22417409
4302:10446449
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