1258:, where one testis fails to descend outside of the body cavity. The majority of these patients will be infertile. In females that are homozygous for the mutation, no abnormalities have been observed. However, heterozygous females have been observed to reach menopause sooner and display a lowered AMH level which also is an indicator of antral follicle count. It is likely that these females reach menopause sooner from having fewer antral follicles, thus more atresia of follicles prior to developing an antrum. These phenotypes were confirmed to be the cause of an AMHR2 mutation from knock out studies performed in mice.
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310:
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184:
209:
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215:
5252:
1207:. It has been reported that the loss of function of the AMHR2 gene results in 50% of XY animals to reverse sex to females and also leads to hyperproliferation of mitotically active germ cells, which leads to the sex reversal. AMH binding to the AMHR2 in mammals causes regression of the oviducts, uterus, and upper 2/3 of the vagina.
38:
1198:
is present in both men and women. AMHR2 is a Type 2 receptor that binds AMH (Anti-Müllerian hormone). This hormone is responsible for Müllerian Duct regression in vertebrates once the SRY gene has been expressed. Some animals such as jawless fish do not express either AMH or its receptors. High
1185:
fold. However, it displays a unique extended finger 1 loop (see image) that is critical to effectively binding its ligand, AMH. The palm region and other fingers are also implicated in binding to AMH, but are relatively unremarkable when compared to other TGF-β type II receptors. As such, these
1540:
Masiakos PT, MacLaughlin DT, Maheswaran S, Teixeira J, Fuller AF, Shah PC, et al. (November 1999). "Human ovarian cancer, cell lines, and primary ascites cells express the human
Mullerian inhibiting substance (MIS) type II receptor, bind, and are responsive to MIS".
2069:
Bakkum-Gamez JN, Aletti G, Lewis KA, Keeney GL, Thomas BM, Navarro-Teulon I, Cliby WA (January 2008). "Müllerian inhibiting substance type II receptor (MISIIR): a novel, tissue-specific target expressed by gynecologic cancers".
3115:
1245:
A syndrome called "Persistent
Mullerian Duct Syndrome" (PMDS) can occur in human males and results in the uterus, vagina, and uterus being present in virilized male. PMDS can be caused by a genetic mutation of
3400:
1448:
Adolfi MC, Nakajima RT, Nóbrega RH, Schartl M (February 2019). "Intersex, Hermaphroditism, and
Gonadal Plasticity in Vertebrates: Evolution of the Müllerian Duct and Amh/Amhr2 Signaling".
3108:
56:
3101:
3308:
323:
222:
2710:
1853:"Mutational analysis of the müllerian-inhibiting substance gene and its receptor gene in Japanese women with polycystic ovary syndrome and premature ovarian failure"
1627:"Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer"
2818:
1966:"Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women"
1931:"Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women"
3856:
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3159:
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2138:
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2159:
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2753:
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4479:
3348:
2873:
2768:
1335:
5272:
4543:
3518:
2758:
4799:
2703:
2391:
1888:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
1668:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
1493:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
1317:
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1215:
Müllerian inhibiting substance type II receptor (MISIIR), also known as the Anti-Müllerian
Hormone Receptor, is expressed by
208:
183:
5127:
1789:"Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications"
1300:
48:
4154:
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3642:
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have been developed that specifically target MISIIR and may be useful as vehicles for drugs and toxins for targeted
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2975:
2368:
2151:
1146:
5122:
2036:"A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity"
2034:
Kevenaar ME, Themmen AP, Rivadeneira F, Uitterlinden AG, Laven JS, van Schoor NM, et al. (September 2007).
2001:"A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity"
1999:
Kevenaar ME, Themmen AP, Rivadeneira F, Uitterlinden AG, Laven JS, van Schoor NM, et al. (September 2007).
1186:
interactions do not contribute significantly to the observed ligand specificity for AMH like the finger 1 loop.
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3132:
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2411:
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2203:
1388:"Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family"
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112:
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1964:
Kevenaar ME, Themmen AP, Laven JS, Sonntag B, Fong SL, Uitterlinden AG, et al. (June 2007).
1929:
Kevenaar ME, Themmen AP, Laven JS, Sonntag B, Fong SL, Uitterlinden AG, et al. (June 2007).
1607:
1473:
1182:
157:
1570:"Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning"
1058:
1037:
999:
978:
1386:
Hart KN, Stocker WA, Nagykery NG, Walton KL, Harrison CA, Donahoe PK, et al. (June 2021).
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2012:
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
1638:
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1504:
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
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153:
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2618:
1717:"AMH and AMHR2 mutations: A spectrum of reproductive phenotypes across vertebrate species"
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Yuan QA, Simmons HH, Robinson MK, Russeva M, Marasco WA, Adams GP (August 2006).
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National Center for
Biotechnology Information, U.S. National Library of Medicine
1322:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1204:
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1392:
Proceedings of the
National Academy of Sciences of the United States of America
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circulating AMH continues on after testis development and is secreted from the
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1235:
1110:
945:
926:
1353:
751:
transmembrane receptor protein serine/threonine kinase signaling pathway
4700:
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4673:
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4455:
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2426:
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1231:
in response to exposure to the Müllerian inhibiting substance (MIS).
1094:
822:
1568:
Yuan QA, Robinson MK, Simmons HH, Russeva M, Adams GP (March 2008).
1141:
also known as Müllerian
Inhibiting Substance Type II Receptor, is a
116:, AMHR, MISR2, MISRII, MRII, anti-Mullerian hormone receptor type 2
5184:
4826:
4819:
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3715:
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3705:
3700:
3695:
3656:
3588:
3583:
3532:
3527:
3453:
3448:
3443:
3409:
3401:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3203:
3188:
3183:
3178:
3173:
3168:
2656:
2488:
2416:
2361:
2356:
2351:
2230:
2223:
2218:
2213:
1168:
1715:
Mullen RD, Ontiveros AE, Moses MM, Behringer RR (November 2019).
785:
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3568:
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3313:
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3250:
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3218:
3213:
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2844:
2336:
2331:
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2321:
2316:
2311:
2208:
1195:
1158:
129:
4953:
4877:
4253:
3144:
3097:
2692:
2120:
736:
negative regulation of anti-Mullerian hormone signaling pathway
634:
transmembrane receptor protein serine/threonine kinase activity
4688:
3223:
3208:
31:
1851:
Wang HQ, Takakura K, Takebayashi K, Noda Y (December 2002).
654:
transforming growth factor beta-activated receptor activity
4949:
756:
transforming growth factor beta receptor signaling pathway
614:
transforming growth factor beta receptor activity, type II
385:
1181:
type II receptor family and adopts the characteristic
5240:
1787:
Teixeira J, Maheswaran S, Donahoe PK (October 2001).
1354:"Entrez Gene: Anti-Mullerian hormone receptor type 2"
550:
5136:
5100:
5069:
5038:
4987:
4891:
4789:
4772:
4755:
4738:
4709:
4569:
4469:
4410:
4301:
4267:
4207:
4183:
4144:
4110:
3816:
3787:
3763:
3744:
3665:
3641:
3602:
3558:
3541:
3517:
3481:
3462:
3428:
3399:
3332:
3298:
3158:
3063:
3033:
3010:
2919:
2886:
2832:
2782:
2744:
2735:
2726:
2670:
2647:
2584:
2517:
2497:
2459:
2404:
2381:
2239:
2167:
2158:
1254:, and these males often have undescended testes or
1051:
1022:
992:
963:
1296:
1294:
1292:
1275:
1273:
1271:
332:
231:
51:for grammar, style, cohesion, tone, or spelling
1301:GRCm38: Ensembl release 89: ENSMUSG00000023047
4965:
3160:Non-specific serine/threonine protein kinases
3109:
2704:
2132:
1443:
1441:
1227:and these cancer cells have been reported to
8:
1371:
1369:
1280:GRCh38: Ensembl release 89: ENSG00000135409
1173:Annotated 3D structure of AMHR2, based on
4972:
4958:
4950:
4888:
4874:
4264:
4250:
3543:Goodpasture-antigen-binding protein kinase
3155:
3141:
3116:
3102:
3094:
2741:
2732:
2711:
2697:
2689:
2401:
2164:
2139:
2125:
2117:
1765:United States National Library of Medicine
796:
576:
373:
272:
169:
4256:Serine/threonine-specific protein kinases
3430:(isocitrate dehydrogenase (NADP+)) kinase
3147:Serine/threonine-specific protein kinases
3129:Serine/threonine-specific protein kinases
2109:at the U.S. National Library of Medicine
2051:
2016:
1981:
1946:
1911:
1868:
1804:
1740:
1691:
1642:
1593:
1516:
1421:
1411:
75:Learn how and when to remove this message
4791:Receptor protein serine/threonine kinase
1763:This article incorporates text from the
766:anti-Mullerian hormone signaling pathway
649:anti-Mullerian hormone receptor activity
629:protein serine/threonine kinase activity
5247:
4774:Low-density-lipoprotein receptor kinase
1267:
1157:in humans that is encoded by the AMHR2
1151:anti-Müllerian hormone receptor type 2
86:
3519:Fas-activated serine/threonine kinase
690:integral component of plasma membrane
337:
298:
293:
236:
195:
190:
7:
4800:Bone morphogenetic protein receptors
1462:10.1146/annurev-animal-020518-114955
3334:Dephospho-(reductase kinase) kinase
1450:Annual Review of Animal Biosciences
27:Receptor for anti-Müllerian hormone
3789:G-protein coupled receptor kinases
1822:Picard JY, Belville C (2002). "".
1048:
1019:
989:
960:
936:
917:
891:
872:
846:
827:
555:
473:
411:
390:
25:
3779:Beta adrenergic receptor kinase-2
3464:(tyrosine 3-monooxygenase) kinase
1824:Journal de la Société de Biologie
5250:
4471:Mitogen-activated protein kinase
1574:Cancer Immunology, Immunotherapy
1139:Anti-Müllerian hormone receptor,
321:
314:
308:
285:
220:
213:
207:
182:
36:
4857:Anti-Müllerian hormone receptor
4740:(acetyl-CoA carboxylase) kinase
4412:(RNA-polymerase)-subunit kinase
3774:Beta adrenergic receptor kinase
3765:Beta adrenergic receptor kinase
2961:Calcitonin gene-related peptide
2160:TGF beta superfamily of ligands
2107:Anti-Mullerian+hormone+receptor
4480:Extracellular signal-regulated
2307:Growth differentiation factors
680:integral component of membrane
539:More reference expression data
1:
4544:P38 mitogen-activated protein
3643:cGMP-dependent protein kinase
3604:cAMP-dependent protein kinase
3300:Pyruvate dehydrogenase kinase
3246:Ataxia telangiectasia mutated
1870:10.1016/s0015-0282(02)04351-0
1644:10.1158/1535-7163.MCT-06-0115
1631:Molecular Cancer Therapeutics
771:pattern specification process
306:
205:
5273:Genes on human chromosome 12
3343:AMP-activated protein kinase
2920:Other neuropeptide receptors
517:epithelium of female urethra
4258:(EC 2.7.11.21-EC 2.7.11.30)
2250:Bone morphogenetic proteins
2084:10.1016/j.ygyno.2007.09.010
1733:10.1016/j.ydbio.2019.07.006
5294:
4185:Elongation factor 2 kinase
3149:(EC 2.7.11.1-EC 2.7.11.20)
2728:G protein-coupled receptor
1836:10.1051/jbio/2002196030217
1203:. It is also expressed in
1087:Chr 15: 102.35 – 102.36 Mb
5128:Michaelis–Menten kinetics
4887:
4873:
4580:MAP kinase kinase kinases
4263:
4249:
4112:Myosin light-chain kinase
3818:Ca2+/calmodulin-dependent
3483:Myosin-heavy-chain kinase
3154:
3140:
3043:Atrial natriuretic factor
2840:Atrial natriuretic factor
1586:10.1007/s00262-007-0376-2
1336:"Mouse PubMed Reference:"
1318:"Human PubMed Reference:"
1125:
1120:
1116:
1109:
1093:
1074:
1055:
1026:
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996:
967:
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943:
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866:
853:
849:
834:
830:
821:
806:
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779:
741:Mullerian duct regression
579:
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563:
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549:
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485:
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355:
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123:
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110:
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89:
5020:Diffusion-limited enzyme
4880:Dual-specificity kinases
3012:Type I cytokine receptor
2467:Activin type 2 receptors
2412:Activin type 1 receptors
2111:Medical Subject Headings
1543:Clinical Cancer Research
1080:Chr 12: 53.42 – 53.43 Mb
731:female gonad development
525:lamina propria of vagina
4303:Cyclin-dependent kinase
1892:The Biochemical Journal
1857:Fertility and Sterility
1672:The Biochemical Journal
1497:The Biochemical Journal
1413:10.1073/pnas.2104809118
746:protein phosphorylation
604:protein kinase activity
505:muscle layer of urethra
3035:Enzyme-linked receptor
2720:Neuropeptide receptors
2369:Anti-müllerian hormone
2152:TGFβ signaling pathway
1806:10.1210/edrv.22.5.0445
1174:
1147:anti-Müllerian hormone
716:male gonad development
459:skeletal muscle tissue
339:15 F3|15 57.58 cM
5113:Eadie–Hofstee diagram
5046:Allosteric regulation
2053:10.1093/humrep/dem176
2018:10.1093/humrep/dem176
1983:10.1093/humrep/dem036
1948:10.1093/humrep/dem036
1721:Developmental Biology
1211:Clinical significance
1172:
761:BMP signaling pathway
659:growth factor binding
513:epithelium of urethra
300:Chromosome 15 (mouse)
198:Chromosome 12 (human)
5123:Lineweaver–Burk plot
4146:Phosphorylase kinase
2072:Gynecologic Oncology
1149:(AMH). Furthermore,
594:transferase activity
497:facial motor nucleus
427:right adrenal cortex
2204:Activin and inhibin
1404:2021PNAS..11804809H
1398:(26): e2104809118.
726:sex differentiation
489:seminiferous tubule
435:left adrenal cortex
5082:Enzyme superfamily
5015:Enzyme promiscuity
4757:Tropomyosin kinase
4711:Tau-protein kinase
2383:TGF beta receptors
2040:Human Reproduction
2005:Human Reproduction
1970:Human Reproduction
1935:Human Reproduction
1904:10.1042/BJ20031961
1767:, which is in the
1684:10.1042/BJ20031961
1509:10.1042/bj20031961
1183:three-finger toxin
1175:
901:ENSMUSG00000023047
709:Biological process
673:Cellular component
599:nucleotide binding
587:Molecular function
431:left adrenal gland
55:You can assist by
5238:
5237:
4947:
4946:
4943:
4942:
4939:
4938:
4869:
4868:
4865:
4864:
4245:
4244:
4241:
4240:
3726:Protein kinase N1
3681:Protein kinase Cζ
3091:
3090:
3006:
3005:
2971:GPCR neuropeptide
2882:
2881:
2737:Hormone receptors
2686:
2685:
2586:Ligand inhibitors
2513:
2512:
2377:
2376:
1898:(Pt 3): 785–793.
1793:Endocrine Reviews
1678:(Pt 3): 785–793.
1549:(11): 3488–3499.
1503:(Pt 3): 785–793.
1177:AMHR2 belongs to
1136:
1135:
1132:
1131:
1105:
1104:
1070:
1069:
1045:
1044:
1011:
1010:
986:
985:
952:
951:
933:
932:
907:
906:
888:
887:
862:
861:
843:
842:
791:
790:
619:metal ion binding
571:
570:
567:
566:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
162:AMHR2 - orthologs
85:
84:
77:
16:(Redirected from
5285:
5255:
5254:
5246:
5118:Hanes–Woolf plot
5061:Enzyme activator
5056:Enzyme inhibitor
5030:Enzyme catalysis
4974:
4967:
4960:
4951:
4889:
4875:
4522:C-Jun N-terminal
4265:
4251:
3755:Rhodopsin kinase
3746:Rhodopsin kinase
3676:Protein kinase C
3667:Protein kinase C
3652:Protein kinase G
3613:Protein kinase A
3224:Protein kinase B
3156:
3142:
3118:
3111:
3104:
3095:
2888:Opioid receptors
2742:
2733:
2713:
2706:
2699:
2690:
2402:
2165:
2141:
2134:
2127:
2118:
2095:
2065:
2055:
2046:(9): 2382–2388.
2030:
2020:
2011:(9): 2382–2388.
1995:
1985:
1976:(6): 1547–1554.
1960:
1950:
1941:(6): 1547–1554.
1925:
1915:
1882:
1872:
1863:(6): 1329–1330.
1847:
1818:
1808:
1755:
1754:
1744:
1712:
1706:
1705:
1695:
1663:
1657:
1656:
1646:
1637:(8): 2096–2105.
1622:
1616:
1615:
1597:
1565:
1559:
1558:
1537:
1531:
1530:
1520:
1488:
1482:
1481:
1445:
1436:
1435:
1425:
1415:
1383:
1373:
1364:
1363:
1361:
1360:
1350:
1344:
1343:
1332:
1326:
1325:
1314:
1308:
1298:
1287:
1277:
1225:prostate cancers
1118:
1117:
1089:
1082:
1065:
1049:
1040:
1020:
1016:RefSeq (protein)
1006:
990:
981:
961:
937:
918:
892:
873:
847:
828:
797:
700:receptor complex
577:
556:
541:
481:
479:Top expressed in
474:
451:body of pancreas
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
87:
80:
73:
69:
66:
60:
40:
39:
32:
21:
5293:
5292:
5288:
5287:
5286:
5284:
5283:
5282:
5263:
5262:
5261:
5249:
5241:
5239:
5234:
5146:Oxidoreductases
5132:
5108:Enzyme kinetics
5096:
5092:List of enzymes
5065:
5034:
5005:Catalytic triad
4983:
4978:
4948:
4935:
4883:
4861:
4785:
4768:
4751:
4734:
4705:
4565:
4465:
4436:P70-S6 Kinase 1
4406:
4297:
4259:
4237:
4203:
4179:
4140:
4106:
3812:
3783:
3759:
3740:
3661:
3637:
3598:
3554:
3537:
3513:
3507:Aurora C kinase
3502:Aurora B kinase
3497:Aurora A kinase
3477:
3458:
3424:
3395:
3328:
3294:
3150:
3136:
3122:
3092:
3087:
3059:
3029:
3002:
2915:
2878:
2857:Cholecystokinin
2828:
2778:
2722:
2717:
2687:
2682:
2666:
2643:
2580:
2509:
2493:
2455:
2385:
2373:
2235:
2182:TGF beta family
2154:
2145:
2103:
2098:
2068:
2033:
1998:
1963:
1928:
1885:
1850:
1821:
1786:
1782:
1780:Further reading
1776:
1759:
1758:
1714:
1713:
1709:
1665:
1664:
1660:
1624:
1623:
1619:
1567:
1566:
1562:
1539:
1538:
1534:
1490:
1489:
1485:
1447:
1446:
1439:
1385:
1375:
1374:
1367:
1358:
1356:
1352:
1351:
1347:
1334:
1333:
1329:
1316:
1315:
1311:
1299:
1290:
1278:
1269:
1264:
1213:
1192:
1167:
1127:View/Edit Mouse
1122:View/Edit Human
1085:
1078:
1075:Location (UCSC)
1061:
1057:
1036:
1032:
1028:
1002:
998:
977:
973:
969:
882:ENSG00000135409
775:
721:phosphorylation
704:
695:plasma membrane
668:
639:protein binding
624:kinase activity
609:hormone binding
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
81:
70:
64:
61:
54:
41:
37:
28:
23:
22:
15:
12:
11:
5:
5291:
5289:
5281:
5280:
5275:
5265:
5264:
5260:
5259:
5236:
5235:
5233:
5232:
5219:
5206:
5193:
5180:
5167:
5154:
5140:
5138:
5134:
5133:
5131:
5130:
5125:
5120:
5115:
5110:
5104:
5102:
5098:
5097:
5095:
5094:
5089:
5084:
5079:
5073:
5071:
5070:Classification
5067:
5066:
5064:
5063:
5058:
5053:
5048:
5042:
5040:
5036:
5035:
5033:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4991:
4989:
4985:
4984:
4979:
4977:
4976:
4969:
4962:
4954:
4945:
4944:
4941:
4940:
4937:
4936:
4934:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4897:
4895:
4885:
4884:
4878:
4871:
4870:
4867:
4866:
4863:
4862:
4860:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4823:
4822:
4817:
4812:
4807:
4796:
4794:
4793:(EC 2.7.11.30)
4787:
4786:
4784:
4783:
4779:
4777:
4776:(EC 2.7.11.29)
4770:
4769:
4767:
4766:
4762:
4760:
4759:(EC 2.7.11.28)
4753:
4752:
4750:
4749:
4745:
4743:
4742:(EC 2.7.11.27)
4736:
4735:
4733:
4732:
4727:
4722:
4716:
4714:
4713:(EC 2.7.11.26)
4707:
4706:
4704:
4703:
4698:
4693:
4692:
4691:
4686:
4681:
4676:
4671:
4666:
4661:
4651:
4650:
4649:
4644:
4639:
4634:
4624:
4623:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4576:
4574:
4573:(EC 2.7.11.25)
4567:
4566:
4564:
4563:
4562:
4561:
4556:
4551:
4541:
4540:
4539:
4534:
4529:
4519:
4518:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4476:
4474:
4473:(EC 2.7.11.24)
4467:
4466:
4464:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4417:
4415:
4414:(EC 2.7.11.23)
4408:
4407:
4405:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4308:
4306:
4305:(EC 2.7.11.22)
4299:
4298:
4296:
4295:
4290:
4285:
4280:
4274:
4272:
4271:(EC 2.7.11.21)
4261:
4260:
4254:
4247:
4246:
4243:
4242:
4239:
4238:
4236:
4235:
4230:
4225:
4220:
4214:
4212:
4211:(EC 2.7.11.21)
4205:
4204:
4202:
4201:
4196:
4190:
4188:
4187:(EC 2.7.11.20)
4181:
4180:
4178:
4177:
4172:
4167:
4162:
4157:
4151:
4149:
4148:(EC 2.7.11.19)
4142:
4141:
4139:
4138:
4133:
4128:
4123:
4117:
4115:
4114:(EC 2.7.11.18)
4108:
4107:
4105:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4034:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3964:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3823:
3821:
3820:(EC 2.7.11.17)
3814:
3813:
3811:
3810:
3805:
3800:
3794:
3792:
3791:(EC 2.7.11.16)
3785:
3784:
3782:
3781:
3776:
3770:
3768:
3767:(EC 2.7.11.15)
3761:
3760:
3758:
3757:
3751:
3749:
3748:(EC 2.7.11.14)
3742:
3741:
3739:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3678:
3672:
3670:
3669:(EC 2.7.11.13)
3663:
3662:
3660:
3659:
3654:
3648:
3646:
3645:(EC 2.7.11.12)
3639:
3638:
3636:
3635:
3630:
3625:
3620:
3615:
3609:
3607:
3606:(EC 2.7.11.11)
3600:
3599:
3597:
3596:
3591:
3586:
3581:
3576:
3571:
3565:
3563:
3562:(EC 2.7.11.10)
3556:
3555:
3553:
3552:
3548:
3546:
3539:
3538:
3536:
3535:
3530:
3524:
3522:
3515:
3514:
3512:
3511:
3510:
3509:
3504:
3499:
3488:
3486:
3479:
3478:
3476:
3475:
3469:
3467:
3460:
3459:
3457:
3456:
3451:
3446:
3441:
3435:
3433:
3426:
3425:
3423:
3422:
3417:
3412:
3406:
3404:
3397:
3396:
3394:
3393:
3392:
3391:
3386:
3381:
3373:
3372:
3371:
3366:
3358:
3357:
3356:
3351:
3339:
3337:
3330:
3329:
3327:
3326:
3321:
3316:
3311:
3305:
3303:
3296:
3295:
3293:
3292:
3291:
3290:
3280:
3279:
3278:
3273:
3268:
3263:
3253:
3248:
3243:
3242:
3241:
3236:
3231:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3165:
3163:
3152:
3151:
3145:
3138:
3137:
3123:
3121:
3120:
3113:
3106:
3098:
3089:
3088:
3086:
3085:
3084:
3083:
3078:
3067:
3065:
3061:
3060:
3058:
3057:
3056:
3055:
3050:
3039:
3037:
3031:
3030:
3028:
3027:
3022:
3016:
3014:
3008:
3007:
3004:
3003:
3001:
3000:
2995:
2994:
2993:
2988:
2983:
2978:
2968:
2963:
2958:
2957:
2956:
2946:
2945:
2944:
2939:
2929:
2923:
2921:
2917:
2916:
2914:
2913:
2908:
2903:
2898:
2892:
2890:
2884:
2883:
2880:
2879:
2877:
2876:
2871:
2870:
2869:
2864:
2854:
2849:
2848:
2847:
2836:
2834:
2830:
2829:
2827:
2826:
2821:
2816:
2811:
2810:
2809:
2804:
2799:
2788:
2786:
2780:
2779:
2777:
2776:
2771:
2766:
2761:
2756:
2750:
2748:
2739:
2730:
2724:
2723:
2718:
2716:
2715:
2708:
2701:
2693:
2684:
2683:
2681:
2680:
2674:
2672:
2668:
2667:
2665:
2664:
2659:
2653:
2651:
2645:
2644:
2642:
2641:
2636:
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2590:
2588:
2582:
2581:
2579:
2578:
2573:
2567:
2558:
2552:
2547:
2542:
2537:
2527:
2525:
2515:
2514:
2511:
2510:
2508:
2507:
2501:
2499:
2495:
2494:
2492:
2491:
2486:
2481:
2480:
2479:
2474:
2463:
2461:
2457:
2456:
2454:
2453:
2452:
2451:
2446:
2436:
2431:
2430:
2429:
2424:
2419:
2408:
2406:
2399:
2379:
2378:
2375:
2374:
2372:
2371:
2366:
2365:
2364:
2359:
2354:
2349:
2344:
2342:Myostatin/GDF8
2339:
2334:
2329:
2324:
2319:
2314:
2304:
2303:
2302:
2297:
2292:
2287:
2282:
2277:
2272:
2267:
2262:
2257:
2246:
2244:
2237:
2236:
2234:
2233:
2228:
2227:
2226:
2221:
2216:
2211:
2201:
2200:
2199:
2194:
2189:
2178:
2176:
2162:
2156:
2155:
2148:Cell signaling
2146:
2144:
2143:
2136:
2129:
2121:
2115:
2114:
2102:
2101:External links
2099:
2097:
2096:
2078:(1): 141–148.
2066:
2031:
1996:
1961:
1926:
1883:
1848:
1830:(3): 217–221.
1819:
1799:(5): 657–674.
1783:
1781:
1778:
1774:
1773:
1757:
1756:
1707:
1658:
1617:
1580:(3): 367–378.
1560:
1532:
1483:
1437:
1365:
1345:
1327:
1309:
1288:
1266:
1265:
1263:
1260:
1256:cryptorchidism
1240:cancer therapy
1212:
1209:
1191:
1188:
1166:
1163:
1134:
1133:
1130:
1129:
1124:
1114:
1113:
1107:
1106:
1103:
1102:
1100:
1098:
1091:
1090:
1083:
1076:
1072:
1071:
1068:
1067:
1053:
1052:
1046:
1043:
1042:
1024:
1023:
1017:
1013:
1012:
1009:
1008:
994:
993:
987:
984:
983:
965:
964:
958:
954:
953:
950:
949:
941:
940:
934:
931:
930:
922:
921:
915:
909:
908:
905:
904:
896:
895:
889:
886:
885:
877:
876:
870:
864:
863:
860:
859:
851:
850:
844:
841:
840:
832:
831:
825:
819:
818:
813:
808:
804:
803:
793:
792:
789:
788:
777:
776:
774:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
712:
710:
706:
705:
703:
702:
697:
692:
687:
682:
676:
674:
670:
669:
667:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
590:
588:
584:
583:
573:
572:
569:
568:
565:
564:
561:
560:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
83:
82:
44:
42:
35:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5290:
5279:
5276:
5274:
5271:
5270:
5268:
5258:
5253:
5248:
5244:
5230:
5226:
5225:
5220:
5217:
5213:
5212:
5207:
5204:
5200:
5199:
5194:
5191:
5187:
5186:
5181:
5178:
5174:
5173:
5168:
5165:
5161:
5160:
5155:
5152:
5148:
5147:
5142:
5141:
5139:
5135:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5105:
5103:
5099:
5093:
5090:
5088:
5087:Enzyme family
5085:
5083:
5080:
5078:
5075:
5074:
5072:
5068:
5062:
5059:
5057:
5054:
5052:
5051:Cooperativity
5049:
5047:
5044:
5043:
5041:
5037:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5010:Oxyanion hole
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4992:
4990:
4986:
4982:
4975:
4970:
4968:
4963:
4961:
4956:
4955:
4952:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4898:
4896:
4894:
4890:
4886:
4881:
4876:
4872:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4802:
4801:
4798:
4797:
4795:
4792:
4788:
4781:
4780:
4778:
4775:
4771:
4764:
4763:
4761:
4758:
4754:
4747:
4746:
4744:
4741:
4737:
4731:
4728:
4726:
4723:
4721:
4718:
4717:
4715:
4712:
4708:
4702:
4699:
4697:
4694:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4656:
4655:
4652:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4629:
4628:
4625:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4582:
4581:
4578:
4577:
4575:
4572:
4568:
4560:
4557:
4555:
4552:
4550:
4547:
4546:
4545:
4542:
4538:
4535:
4533:
4530:
4528:
4525:
4524:
4523:
4520:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4481:
4478:
4477:
4475:
4472:
4468:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4416:
4413:
4409:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4309:
4307:
4304:
4300:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4275:
4273:
4270:
4266:
4262:
4257:
4252:
4248:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4215:
4213:
4210:
4206:
4200:
4197:
4195:
4192:
4191:
4189:
4186:
4182:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4152:
4150:
4147:
4143:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4118:
4116:
4113:
4109:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3824:
3822:
3819:
3815:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3790:
3786:
3780:
3777:
3775:
3772:
3771:
3769:
3766:
3762:
3756:
3753:
3752:
3750:
3747:
3743:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3673:
3671:
3668:
3664:
3658:
3655:
3653:
3650:
3649:
3647:
3644:
3640:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3610:
3608:
3605:
3601:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3566:
3564:
3561:
3557:
3550:
3549:
3547:
3545:(EC 2.7.11.9)
3544:
3540:
3534:
3531:
3529:
3526:
3525:
3523:
3521:(EC 2.7.11.8)
3520:
3516:
3508:
3505:
3503:
3500:
3498:
3495:
3494:
3493:
3492:Aurora kinase
3490:
3489:
3487:
3485:(EC 2.7.11.7)
3484:
3480:
3474:
3471:
3470:
3468:
3466:(EC 2.7.11.6)
3465:
3461:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3436:
3434:
3432:(EC 2.7.11.5)
3431:
3427:
3421:
3418:
3416:
3413:
3411:
3408:
3407:
3405:
3403:(EC 2.7.11.4)
3402:
3398:
3390:
3387:
3385:
3382:
3380:
3377:
3376:
3374:
3370:
3367:
3365:
3362:
3361:
3359:
3355:
3352:
3350:
3347:
3346:
3344:
3341:
3340:
3338:
3336:(EC 2.7.11.3)
3335:
3331:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3306:
3304:
3302:(EC 2.7.11.2)
3301:
3297:
3289:
3286:
3285:
3284:
3281:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3258:
3257:
3256:EIF-2 kinases
3254:
3252:
3249:
3247:
3244:
3240:
3237:
3235:
3232:
3230:
3227:
3226:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3166:
3164:
3162:(EC 2.7.11.1)
3161:
3157:
3153:
3148:
3143:
3139:
3134:
3130:
3126:
3119:
3114:
3112:
3107:
3105:
3100:
3099:
3096:
3082:
3079:
3077:
3074:
3073:
3072:
3069:
3068:
3066:
3062:
3054:
3051:
3049:
3046:
3045:
3044:
3041:
3040:
3038:
3036:
3032:
3026:
3023:
3021:
3018:
3017:
3015:
3013:
3009:
2999:
2996:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2972:
2969:
2967:
2964:
2962:
2959:
2955:
2952:
2951:
2950:
2947:
2943:
2940:
2938:
2935:
2934:
2933:
2930:
2928:
2925:
2924:
2922:
2918:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2893:
2891:
2889:
2885:
2875:
2872:
2868:
2865:
2863:
2860:
2859:
2858:
2855:
2853:
2850:
2846:
2843:
2842:
2841:
2838:
2837:
2835:
2831:
2825:
2822:
2820:
2817:
2815:
2812:
2808:
2805:
2803:
2800:
2798:
2795:
2794:
2793:
2790:
2789:
2787:
2785:
2781:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2751:
2749:
2747:
2743:
2740:
2738:
2734:
2731:
2729:
2725:
2721:
2714:
2709:
2707:
2702:
2700:
2695:
2694:
2691:
2679:
2676:
2675:
2673:
2669:
2663:
2660:
2658:
2655:
2654:
2652:
2650:
2646:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2591:
2589:
2587:
2583:
2577:
2574:
2571:
2568:
2566:
2562:
2559:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2532:
2529:
2528:
2526:
2524:
2520:
2516:
2506:
2503:
2502:
2500:
2496:
2490:
2487:
2485:
2482:
2478:
2475:
2473:
2470:
2469:
2468:
2465:
2464:
2462:
2458:
2450:
2447:
2445:
2442:
2441:
2440:
2437:
2435:
2432:
2428:
2425:
2423:
2420:
2418:
2415:
2414:
2413:
2410:
2409:
2407:
2403:
2400:
2397:
2393:
2389:
2384:
2380:
2370:
2367:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2309:
2308:
2305:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2258:
2256:
2253:
2252:
2251:
2248:
2247:
2245:
2243:
2238:
2232:
2229:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2206:
2205:
2202:
2198:
2195:
2193:
2190:
2188:
2185:
2184:
2183:
2180:
2179:
2177:
2175:
2171:
2166:
2163:
2161:
2157:
2153:
2149:
2142:
2137:
2135:
2130:
2128:
2123:
2122:
2119:
2112:
2108:
2105:
2104:
2100:
2093:
2089:
2085:
2081:
2077:
2073:
2067:
2063:
2059:
2054:
2049:
2045:
2041:
2037:
2032:
2028:
2024:
2019:
2014:
2010:
2006:
2002:
1997:
1993:
1989:
1984:
1979:
1975:
1971:
1967:
1962:
1958:
1954:
1949:
1944:
1940:
1936:
1932:
1927:
1923:
1919:
1914:
1909:
1905:
1901:
1897:
1893:
1889:
1884:
1880:
1876:
1871:
1866:
1862:
1858:
1854:
1849:
1845:
1841:
1837:
1833:
1829:
1826:(in French).
1825:
1820:
1816:
1812:
1807:
1802:
1798:
1794:
1790:
1785:
1784:
1779:
1777:
1772:
1770:
1769:public domain
1766:
1761:
1760:
1752:
1748:
1743:
1738:
1734:
1730:
1726:
1722:
1718:
1711:
1708:
1703:
1699:
1694:
1689:
1685:
1681:
1677:
1673:
1669:
1662:
1659:
1654:
1650:
1645:
1640:
1636:
1632:
1628:
1621:
1618:
1613:
1609:
1605:
1601:
1596:
1591:
1587:
1583:
1579:
1575:
1571:
1564:
1561:
1556:
1552:
1548:
1544:
1536:
1533:
1528:
1524:
1519:
1514:
1510:
1506:
1502:
1498:
1494:
1487:
1484:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1444:
1442:
1438:
1433:
1429:
1424:
1419:
1414:
1409:
1405:
1401:
1397:
1393:
1389:
1382:
1378:
1372:
1370:
1366:
1355:
1349:
1346:
1341:
1337:
1331:
1328:
1323:
1319:
1313:
1310:
1306:
1302:
1297:
1295:
1293:
1289:
1285:
1281:
1276:
1274:
1272:
1268:
1261:
1259:
1257:
1253:
1249:
1243:
1241:
1237:
1232:
1230:
1226:
1222:
1218:
1210:
1208:
1206:
1202:
1201:Sertoli Cells
1197:
1189:
1187:
1184:
1180:
1171:
1164:
1162:
1160:
1156:
1152:
1148:
1144:
1140:
1128:
1123:
1119:
1115:
1112:
1108:
1101:
1099:
1096:
1092:
1088:
1084:
1081:
1077:
1073:
1066:
1064:
1060:
1054:
1050:
1047:
1041:
1039:
1035:
1031:
1025:
1021:
1018:
1014:
1007:
1005:
1001:
995:
991:
988:
982:
980:
976:
972:
966:
962:
959:
957:RefSeq (mRNA)
955:
948:
947:
942:
938:
935:
929:
928:
923:
919:
916:
914:
910:
903:
902:
897:
893:
890:
884:
883:
878:
874:
871:
869:
865:
858:
857:
852:
848:
845:
839:
838:
833:
829:
826:
824:
820:
817:
814:
812:
809:
805:
802:
798:
794:
787:
783:
778:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
713:
711:
708:
707:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
677:
675:
672:
671:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
595:
592:
591:
589:
586:
585:
582:
581:Gene ontology
578:
574:
562:
557:
554:
552:
548:
540:
535:
524:
521:soleus muscle
520:
516:
512:
509:Gonadal ridge
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
93:
88:
79:
76:
68:
58:
52:
50:
45:This article
43:
34:
33:
30:
19:
5224:Translocases
5221:
5208:
5195:
5182:
5169:
5159:Transferases
5156:
5143:
5000:Binding site
4856:
4431:P70S6 kinase
2774:Somatostatin
2746:Hypothalamic
2483:
2075:
2071:
2043:
2039:
2008:
2004:
1973:
1969:
1938:
1934:
1895:
1891:
1860:
1856:
1827:
1823:
1796:
1792:
1775:
1762:
1724:
1720:
1710:
1675:
1671:
1661:
1634:
1630:
1620:
1577:
1573:
1563:
1546:
1542:
1535:
1500:
1496:
1486:
1453:
1449:
1395:
1391:
1357:. Retrieved
1348:
1339:
1330:
1321:
1312:
1244:
1233:
1214:
1205:Leydig cells
1193:
1176:
1150:
1138:
1137:
1063:NP_001343504
1056:
1034:NP_001158163
1030:NP_001158162
1027:
1004:NM_001356575
997:
975:NM_001164691
971:NM_001164690
968:
944:
925:
899:
880:
854:
835:
815:
810:
664:SMAD binding
493:spermatocyte
455:right testis
401:
394:
360:102,363,068
347:102,353,802
121:External IDs
71:
62:
49:copy editing
47:may require
46:
29:
18:AMHR2 (gene)
4995:Active site
4882:(EC 2.7.12)
4269:Polo kinase
4209:Polo kinase
2998:Neurotensin
2927:Angiotensin
2792:Vasopressin
2649:Coreceptors
2609:Follistatin
2519:Transducers
1456:: 149–172.
1234:Monoclonal
644:ATP binding
447:left testis
443:right ovary
259:53,431,672
246:53,423,855
99:Identifiers
5267:Categories
5198:Isomerases
5172:Hydrolases
5039:Regulation
3560:IκB kinase
3135:2.7.11-12)
2949:Tachykinin
2932:Bradykinin
2911:Nociceptin
2852:Calcitonin
2505:betaglycan
2240:Ligand of
2168:Ligand of
1727:(1): 1–9.
1359:2018-06-07
1307:, May 2017
1286:, May 2017
1262:References
1236:Antibodies
439:left ovary
405:(ortholog)
142:HomoloGene
57:editing it
5278:EC 2.7.11
5077:EC number
3686:PKC alpha
3025:Prolactin
2784:Pituitary
1384:;
1252:missenses
1248:deletions
1165:Structure
1059:NP_653130
1038:NP_065434
1000:NM_144547
979:NM_020547
801:Orthologs
150:GeneCards
65:July 2024
5101:Kinetics
5025:Cofactor
4988:Activity
4042:KIAA0999
3937:MAPKAPK5
3932:MAPKAPK3
3927:MAPKAPK2
2814:Oxytocin
2594:Cerberus
2092:17988723
2062:17636279
2027:17636279
1992:17337470
1957:17337470
1922:14750901
1879:12477536
1844:12462075
1815:11588147
1751:31301298
1702:14750901
1653:16928831
1612:13075446
1604:17676323
1595:11031043
1555:10589763
1527:14750901
1478:52954655
1470:30303691
1432:34155118
1303:–
1282:–
1229:apoptose
1190:Function
1145:for the
1143:receptor
1111:Wikidata
780:Sources:
685:membrane
238:12q13.13
5257:Biology
5211:Ligases
4981:Enzymes
4701:MAP3K14
4679:MAP3K11
4674:MAP3K10
4664:MAP3K13
4659:MAP3K12
4461:RPS6KC1
4456:RPS6KA1
4451:RPS6KA3
4446:RPS6KA2
4441:RPS6KB2
4426:RPS6KA4
4421:RPS6KA5
4072:Kalirin
4037:SNF1LK2
3276:EIF2AK4
3271:EIF2AK3
3125:Kinases
2966:Galanin
2614:Gremlin
2604:Decorin
2599:Chordin
2498:TGFBR3:
2460:TGFBR2:
2405:TGFBR1:
2388:Activin
1913:1224123
1742:6754765
1693:1224123
1518:1224123
1423:8256043
1400:Bibcode
1305:Ensembl
1284:Ensembl
1217:ovarian
1155:protein
913:UniProt
868:Ensembl
807:Species
786:QuickGO
380:pattern
106:Aliases
5243:Portal
5185:Lyases
4931:MAP2K7
4926:MAP2K6
4921:MAP2K5
4916:MAP2K4
4911:MAP2K3
4906:MAP2K2
4901:MAP2K1
4852:ACVRL1
4847:ACVR2B
4842:ACVR2A
4837:ACVR1C
4832:ACVR1B
4815:BMPR1B
4810:BMPR1A
4684:MAP3K7
4669:MAP3K9
4620:MAP3K8
4615:MAP3K7
4610:MAP3K6
4605:MAP3K5
4600:MAP3K4
4595:MAP3K3
4590:MAP3K2
4585:MAP3K1
4559:MAPK14
4554:MAPK13
4549:MAPK11
4537:MAPK10
4515:MAPK15
4510:MAPK12
4402:CDC2L1
4377:CDC2L5
4052:SNF1LK
3877:CAMK2G
3872:CAMK2D
3867:CAMK2B
3862:CAMK2A
3852:CAMK1G
3847:CAMK1D
3842:CAMK1B
3837:CAMK1A
3691:PRKCB1
3628:PRKACA
3623:PRKACB
3618:PRKACG
3594:IKBKAP
3420:BCKDHB
3415:BCKDHA
3389:PRKAG3
3384:PRKAG2
3379:PRKAG1
3369:PRKAB2
3364:PRKAB1
3354:PRKAA2
3349:PRKAA1
3194:STK38L
2662:Cripto
2629:Noggin
2561:I-SMAD
2531:R-SMAD
2477:ACVR2B
2472:ACVR2A
2449:BMPR1B
2444:BMPR1A
2434:ACVRL1
2427:ACVR1C
2422:ACVR1B
2396:family
2197:TGF-β3
2192:TGF-β2
2187:TGF-β1
2113:(MeSH)
2090:
2060:
2025:
1990:
1955:
1920:
1910:
1877:
1842:
1813:
1749:
1739:
1700:
1690:
1651:
1610:
1602:
1592:
1553:
1525:
1515:
1476:
1468:
1430:
1420:
1223:, and
1221:breast
1097:search
1095:PubMed
946:Q8K592
927:Q16671
856:110542
823:Entrez
551:BioGPS
463:spleen
138:105062
130:600956
5137:Types
4893:MAP2K
4827:ACVR1
4820:BMPR2
4805:BMPR1
4730:GSK-3
4571:MAP3K
4532:MAPK9
4527:MAPK8
4505:MAPK7
4500:MAPK6
4495:MAPK4
4490:MAPK3
4485:MAPK1
4397:PFTK1
4392:PCTK3
4387:PCTK2
4382:PCTK1
4372:CDK12
4367:CDK10
4342:CDKL5
4322:CDKL2
4199:STK19
4194:EEF2K
4175:PHKG2
4170:PHKG1
4160:PHKA2
4155:PHKA1
4136:MYLK4
4131:MYLK3
4126:MYLK2
4102:DCLK1
4097:Titin
4087:TRIB3
4082:TRIB2
4077:TRIB1
4067:TSSK2
4047:STK40
4032:PSKH1
4027:PRKD3
4022:PRKD2
4002:PHKG2
3997:PHKG1
3987:OBSCN
3982:NUAK2
3977:NUAK1
3972:MKNK2
3967:MKNK1
3957:MARK4
3952:MARK3
3947:MARK2
3942:MARK1
3922:STK11
3917:DAPK3
3912:DAPK2
3907:DAPK1
3902:CHEK2
3897:CHEK1
3882:CAMK4
3857:CAMK2
3832:CAMK1
3827:BRSK2
3721:PRKCQ
3716:PRKCI
3711:PRKCG
3706:PRKCH
3701:PRKCE
3696:PRKCD
3657:PRKG1
3589:IKBKG
3584:IKBKE
3533:STK10
3528:FASTK
3454:IDH3G
3449:IDH3B
3444:IDH3A
3410:BCKDK
3204:ROCK1
3189:STK38
3184:MAST2
3179:MAST1
3174:LATS2
3169:LATS1
3071:Sigma
3064:Other
2954:TACR1
2901:Kappa
2896:Delta
2833:Other
2671:Other
2657:BAMBI
2639:THBS1
2624:LTBP1
2619:Lefty
2576:SMAD4
2570:SMAD7
2565:SMAD6
2555:SMAD9
2550:SMAD5
2545:SMAD3
2540:SMAD2
2535:SMAD1
2489:BMPR2
2484:AMHR2
2439:BMPR1
2417:ACVR1
2362:GDF15
2357:GDF11
2352:GDF10
2300:BMP15
2295:BMP10
2290:BMP8b
2285:BMP8a
2231:Nodal
2224:INHBC
2219:INHBB
2214:INHBA
2174:TGFBR
1608:S2CID
1474:S2CID
1250:, or
1179:TGF-β
1153:is a
816:Mouse
811:Human
782:Amigo
501:ovary
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:AMHR2
146:10746
113:AMHR2
90:AMHR2
5229:list
5222:EC7
5216:list
5209:EC6
5203:list
5196:EC5
5190:list
5183:EC4
5177:list
5170:EC3
5164:list
5157:EC2
5151:list
5144:EC1
4720:TPK1
4696:CDC7
4654:MLKs
4647:KSR2
4642:KSR1
4637:BRAF
4632:ARAF
4627:RAFs
4362:CDK9
4357:CDK8
4352:CDK7
4347:CDK6
4337:CDK5
4332:CDK4
4327:CDK3
4317:CDK2
4312:CDK1
4293:PLK4
4288:PLK3
4283:PLK2
4278:PLK1
4233:PLK4
4228:PLK3
4223:PLK2
4218:PLK1
4165:PHKB
4121:MYLK
4092:TRIO
4062:SPEG
4057:SNRK
4017:PKD1
4012:PIM2
4007:PIM1
3992:PASK
3962:MELK
3892:CASK
3887:MLCK
3808:GRK6
3803:GRK5
3798:GRK4
3736:PKN3
3731:PKN2
3633:PRKY
3579:TBK1
3574:IKK2
3569:CHUK
3473:STK4
3439:IDH2
3324:PDK4
3319:PDK3
3314:PDK2
3309:PDK1
3288:WEE1
3283:Wee1
3251:mTOR
3239:AKT3
3234:AKT2
3229:AKT1
3219:SGK3
3214:SGK2
3053:NPR2
3048:NPR1
2845:NPR3
2819:LHCG
2764:LHRH
2678:SARA
2634:PARN
2523:SMAD
2347:GDF9
2337:GDF7
2332:GDF6
2327:GDF5
2322:GDF3
2317:GDF2
2312:GDF1
2280:BMP7
2275:BMP6
2270:BMP5
2265:BMP4
2260:BMP3
2255:BMP2
2242:BMPR
2209:INHA
2170:ACVR
2088:PMID
2058:PMID
2023:PMID
1988:PMID
1953:PMID
1918:PMID
1875:PMID
1840:PMID
1811:PMID
1747:PMID
1698:PMID
1649:PMID
1600:PMID
1551:PMID
1523:PMID
1466:PMID
1428:PMID
1381:7L0J
1196:gene
1194:The
1159:gene
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
126:OMIM
4725:TTK
4689:ZAK
3266:HRI
3261:PKR
3209:SGK
3199:CIT
2976:B/W
2874:VIP
2824:TSH
2769:TRH
2759:FSH
2754:CRH
2392:BMP
2172:or
2080:doi
2076:108
2048:doi
2013:doi
1978:doi
1943:doi
1908:PMC
1900:doi
1896:379
1865:doi
1832:doi
1828:196
1801:doi
1737:PMC
1729:doi
1725:455
1688:PMC
1680:doi
1676:379
1639:doi
1590:PMC
1582:doi
1513:PMC
1505:doi
1501:379
1458:doi
1418:PMC
1408:doi
1396:118
1377:PDB
837:269
559:n/a
356:End
255:End
158:OMA
134:MGI
5269::
3375:γ
3360:β
3345:α
3133:EC
3127::
3020:GH
2981:FF
2942:B2
2937:B1
2906:Mu
2802:1B
2797:1A
2394:,
2390:,
2150::
2086:.
2074:.
2056:.
2044:22
2042:.
2038:.
2021:.
2009:22
2007:.
2003:.
1986:.
1974:22
1972:.
1968:.
1951:.
1939:22
1937:.
1933:.
1916:.
1906:.
1894:.
1890:.
1873:.
1861:78
1859:.
1855:.
1838:.
1809:.
1797:22
1795:.
1791:.
1745:.
1735:.
1723:.
1719:.
1696:.
1686:.
1674:.
1670:.
1647:.
1633:.
1629:.
1606:.
1598:.
1588:.
1578:57
1576:.
1572:.
1545:.
1521:.
1511:.
1499:.
1495:.
1472:.
1464:.
1452:.
1440:^
1426:.
1416:.
1406:.
1394:.
1390:.
1379::
1368:^
1338:.
1320:.
1291:^
1270:^
1242:.
1219:,
1161:.
784:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
5245::
5231:)
5227:(
5218:)
5214:(
5205:)
5201:(
5192:)
5188:(
5179:)
5175:(
5166:)
5162:(
5153:)
5149:(
4973:e
4966:t
4959:v
4782:-
4765:-
4748:-
3551:-
3131:(
3117:e
3110:t
3103:v
3081:2
3076:1
2991:Y
2986:S
2867:B
2862:A
2807:2
2712:e
2705:t
2698:v
2572:)
2563:(
2557:)
2533:(
2521:/
2398:)
2386:(
2140:e
2133:t
2126:v
2094:.
2082::
2064:.
2050::
2029:.
2015::
1994:.
1980::
1959:.
1945::
1924:.
1902::
1881:.
1867::
1846:.
1834::
1817:.
1803::
1771:.
1753:.
1731::
1704:.
1682::
1655:.
1641::
1635:5
1614:.
1584::
1557:.
1547:5
1529:.
1507::
1480:.
1460::
1454:7
1434:.
1410::
1402::
1362:.
1342:.
1324:.
280:)
177:)
160::
78:)
72:(
67:)
63:(
59:.
53:.
20:)
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