42:
2594:
Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogné K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V (6 February 2003). "Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death".
3567:
Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogné K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V (February 2003). "Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death".
68:
2270:
Eber SW, Gonzalez JM, Lux ML, Scarpa AL, Tse WT, Dornwell M, Herbers J, Kugler W, Ozcan R, Pekrun A, Gallagher PG, Schröter W, Forget BG, Lux SE (June 1996). "Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis".
2175:"The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes"
3619:
Sherman J, Tester DJ, Ackerman MJ (November 2005). "Targeted mutational analysis of ankyrin-B in 541 consecutive, unrelated patients referred for long QT syndrome genetic testing and 200 healthy subjects".
3714:
Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ (13 September 2011).
1655:
mutations to the range of severity of cardiac phenotypes, and initial evidence suggests that the varying degrees of loss of function of ankyrin-B may explain the effect of any particular mutation.
1746:
expression, specifically Ca(v)1.3, which is responsible for low voltage-activated L-type Ca(2+) currents. Ankyrin-B directly associates with and is required for targeting Ca(v)1.3 to membranes.
3764:
Le
Scouarnec S, Bhasin N, Vieyres C, Hund TJ, Cunha SR, Koval O, Marionneau C, Chen B, Wu Y, Demolombe S, Song LS, Le Marec H, Probst V, Schott JJ, Anderson ME, Mohler PJ (7 October 2008).
1428:. Mechanistic explanations underlying these effects were explained in a later study conducted in the ankyrin-B (-/+) mice, which showed that reduction of ankyrin-B alters the transport of
1337:
by 3-fold and destabilizes its proper localization; all of these effects were rescued by reintroducing ankyrin-B. Moreover, a specific sequence in ankyrin-B (absent in other ankyrin
1243:
regulatory domain which is the least conserved and subject to variation, and determines ankyrin-B activity. The membrane-binding region of ankyrin-B is composed of 24 consecutive
1417:
3426:
Zhang T, Moss A, Cong P, Pan M, Chang B, Zheng L, Fang Q, Zareba W, Robinson J, Lin C, Li Z, Wei J, Zeng Q, Long QT International
Registry I, HVP-China I, Qi M (November 2010).
3090:"Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes"
2422:"Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40"
1764:, as well as dysfunction in ankyrin-B-based trafficking pathways in primary and subsidiary pacemaker cells. In a large genotype-phenotype study of 874 patients with
4218:
3088:
Mohler PJ, Le
Scouarnec S, Denjoy I, Lowe JS, Guicheney P, Caron L, Driskell IM, Schott JJ, Norris K, Leenhardt A, Kim RB, Escande D, Roden DM (30 January 2007).
1397:
1393:
3913:
Lopes LR, Syrris P, Guttmann OP, O'Mahony C, Tang HC, Dalageorgou C, Jenkins S, Hubank M, Monserrat L, McKenna WJ, Plagnol V, Elliott PM (February 2015).
3337:
Alders M, Christiaans I, Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean L, Bird TD, Fong CT, Smith R, Stephens K (1993). "Long QT Syndrome".
4183:
3532:
Robaei D, Ford T, Ooi SY (February 2015). "Ankyrin-B syndrome: a case of sinus node dysfunction, atrial fibrillation and prolonged QT in a young adult".
150:
669:
4108:"Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel"
3045:
2510:
DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ (December 2012).
1892:
Schott JJ, Charpentier F, Peltier S, Foley P, Drouin E, Bouhour JB, Donnelly P, Vergnaud G, Bachner L, Moisan JP, et al. (November 1995).
3296:
Sedlacek K, Stark K, Cunha SR, Pfeufer A, Weber S, Berger I, Perz S, Kääb S, Wichmann HE, Mohler PJ, Hengstenberg C, Jeron A (December 2008).
1499:
in patients. Studies from other labs have shed light on the requirement of ankyrin-B in the targeting and post-translational stability of the
4846:
6543:
1857:
2902:"Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury"
4211:
2316:"Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes"
2086:"Exon organization and novel alternative splicing of the human ANK2 gene: implications for cardiac function and human cardiac disease"
2736:
Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, Mohler PJ (29 September 2009).
1743:
1695:
3962:
Kashef F, Li J, Wright P, Snyder J, Suliman F, Kilic A, Higgins RS, Anderson ME, Binkley PF, Hund TJ, Mohler PJ (31 August 2012).
2378:"Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B"
2697:"Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B"
1878:
5365:
3915:"Novel genotype-phenotype associations demonstrated by high-throughput sequencing in patients with hypertrophic cardiomyopathy"
1683:
1520:
1334:
1322:
1303:
5634:
5477:
4204:
1719:
1464:
1354:
3043:
Kline CF, Mohler PJ (July 2006). "Weighing in on molecular anchors: the role of ankyrin polypeptides in human arrhythmia".
6513:
6067:
138:
3655:
Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V (15 June 2004).
4774:
1765:
1702:
mutations localized in the regulatory domain of ankyrin-2, which is specific to the ankyrin-2 isoform, indicated that
1587:
1567:
1559:
1188:
6245:
3249:"Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias"
1678:. The mechanistic underpinnings of this mutation include abnormal expression and targeting of the sodium pump, the
3188:
Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V (17 October 2007).
2221:"Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain"
6478:
4153:
1711:
1679:
1508:
1500:
1476:
1460:
1346:
3866:"Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice"
65:
6538:
2648:"Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity"
2420:
Mohler PJ, Hoffman JA, Davis JQ, Abdi KM, Kim CR, Jones SK, Davis LH, Roberts KF, Bennett V (11 June 2004).
1784:
1715:
1456:
1350:
712:
1368:
Additional insights into ankyrin-B function have come from studies employing ankyrin-B transgenic animals.
1159:. Ankyrin-2 plays an essential role in the localization and membrane stabilization of ion transporters and
3766:"Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease"
3190:"Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence"
3142:
1780:
1571:
1302:
domain of ankyrin-B determines both the subcellular localization as well as activity in restoring normal
4897:
4251:
3350:
3477:"Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis"
6533:
5166:
3777:
3668:
3577:
3488:
3201:
2749:
2604:
2327:
2314:
Mohler PJ, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori SG, Bennett V (14 December 2004).
1648:
1452:
1425:
1247:, and it is the membrane-binding domain of ankyrins that confer functional differences among ankyrin
1212:
3964:"Ankyrin-B protein in heart failure: identification of a new component of metazoan cardioprotection"
3147:
1783:
and non-ischemic heart failure, ankyrin-B levels are altered. Further mechanistic study showed that
6473:
5106:
2463:"Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins"
1795:
regulate cardiac ankyrin-B levels, and ankyrin-B is required for normal cardioprotection following
1753:
1640:
1184:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
986:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
870:
860:
856:
844:
797:
125:
3000:
Mohler PJ (October 2006). "Ankyrins and human disease: what the electrophysiologist should know".
4926:
4556:
4149:
4088:
3601:
3170:
3070:
3025:
2628:
2559:
Vatta M, Chen PS (December 2012). "CaMKII and ryanodine receptor as new antiarrhythmic targets".
2296:
1796:
1687:
1480:
1421:
1307:
162:
852:
848:
805:
801:
419:
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
3475:
Wolf RM, Glynn P, Hashemi S, Zarei K, Mitchell CC, Anderson ME, Mohler PJ, Hund TJ (May 2013).
6324:
6027:
4688:
4160:
4129:
4080:
4036:
3995:
3944:
3895:
3846:
3805:
3746:
3696:
3637:
3593:
3549:
3514:
3457:
3408:
3338:
3319:
3278:
3229:
3162:
3111:
3062:
3017:
2982:
2933:
2882:
2828:
2777:
2718:
2677:
2620:
2576:
2541:
2492:
2443:
2399:
2355:
2288:
2252:
2196:
2150:
2115:
2066:
2017:
1915:
1773:
1401:
118:
58:
6047:
4015:"Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes"
2512:"CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome"
1726:
were consistent observations. This study demonstrated that common pathogenic features of all
6272:
5979:
5964:
5959:
5954:
5949:
5939:
5860:
5569:
5549:
5519:
5514:
5396:
4751:
4746:
4119:
4070:
4026:
3985:
3975:
3934:
3926:
3885:
3877:
3836:
3795:
3785:
3736:
3728:
3686:
3676:
3629:
3585:
3541:
3504:
3496:
3447:
3439:
3398:
3390:
3379:"Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome"
3309:
3268:
3260:
3219:
3209:
3152:
3101:
3054:
3009:
2972:
2964:
2923:
2913:
2872:
2862:
2818:
2808:
2767:
2757:
2738:"Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation"
2708:
2667:
2659:
2612:
2568:
2531:
2523:
2482:
2474:
2433:
2389:
2345:
2335:
2280:
2242:
2232:
2186:
2142:
2105:
2097:
2056:
2048:
2007:
1999:
1905:
1739:
1703:
1671:
1644:
1627:
1532:
1512:
1496:
1484:
1295:
1283:
play essential roles in the localization and membrane stabilization of ion transporters and
1180:
1176:
6189:
6184:
6179:
6174:
5929:
5919:
5909:
5904:
5875:
5579:
5574:
4621:
4509:
4499:
4474:
4454:
4358:
4338:
3717:"Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation"
1239:; a central region with a highly conserved spectrin binding domain and death domain; and a
6414:
5028:
4878:
4761:
4581:
3363:
1583:
1579:
1551:
1279:
has been shown to be essential in normal function of erythrocytes; however, ankyrin-B and
1256:
158:
3781:
3672:
3581:
3492:
3205:
2753:
2608:
2331:
6377:
6240:
4937:
4768:
4277:
4059:"An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan"
3990:
3963:
3939:
3914:
3890:
3865:
3800:
3765:
3741:
3716:
3509:
3476:
3452:
3427:
3403:
3378:
3273:
3248:
3224:
3189:
2977:
2952:
2928:
2901:
2877:
2850:
2823:
2796:
2772:
2737:
2672:
2647:
2536:
2511:
2487:
2462:
2247:
2220:
2110:
2085:
2061:
2036:
2012:
1987:
1910:
1893:
1723:
1555:
1547:
1528:
1504:
1472:
1369:
1358:
1326:
1318:
1294:
Functional insights into ankyrin-B function have come from studies employing ankyrin-B
1288:
1260:
1252:
1244:
1236:
1220:
1164:
1156:
4124:
4107:
3732:
3691:
3656:
3157:
3130:
3106:
3089:
2350:
2315:
603:
598:
593:
588:
583:
578:
573:
568:
563:
558:
553:
548:
543:
538:
533:
528:
523:
518:
513:
508:
503:
498:
493:
488:
483:
478:
473:
468:
463:
458:
453:
448:
443:
438:
433:
428:
423:
418:
413:
408:
403:
398:
393:
388:
372:
367:
362:
357:
352:
347:
342:
337:
332:
327:
322:
317:
312:
307:
302:
297:
292:
287:
282:
277:
272:
267:
262:
257:
252:
247:
231:
226:
221:
216:
211:
206:
201:
196:
191:
6527:
6441:
6436:
5401:
5271:
5220:
5170:
5110:
5032:
5000:
4941:
4727:
4246:
4187:
4169:
3013:
1735:
1710:
mutations; however, the effect on Ca(2+) dynamics and localization/expression of the
1554:, respectively. Exon 43′ in ankyrin-B is specifically and predominantly expressed in
1516:
1441:
1314:
1311:
1207:
gene is approximately 560 kb in size and consists of 53 exons on human chromosome 4;
1192:
178:
4092:
3314:
3297:
3174:
3029:
2900:
Ayalon G, Hostettler JD, Hoffman J, Kizhatil K, Davis JQ, Bennett V (4 March 2011).
2300:
1986:
Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR (24 June 2015).
6285:
5340:
5095:
4639:
4231:
3605:
3298:"Common genetic variants in ANK2 modulate QT interval: results from the KORA study"
2632:
6257:
6235:
3247:
Bush WS, Crawford DC, Alexander C, George AL J, Roden DM, Ritchie MD (June 2009).
3074:
2376:
Mohler PJ, Davis JQ, Davis LH, Hoffman JA, Michaely P, Bennett V (26 March 2004).
1988:"Identification and characterization of two ankyrin-B isoforms in mammalian heart"
1495:) blocks the formation of this complex, which provides a mechanism behind cardiac
1372:
from ankyrin-B (-/+) mice exhibited irregular spatial patterns and periodicity of
3930:
3214:
2237:
1523:, which is necessary for normal channel trafficking and targeting the channel to
166:
6431:
6382:
6252:
6142:
5472:
4916:
4871:
4790:
4712:
4260:
3881:
3633:
3500:
3394:
2968:
2663:
2572:
2527:
2101:
2052:
1862:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1757:
1731:
1636:
1413:
1405:
1342:
1284:
1160:
4196:
4075:
4058:
3770:
Proceedings of the
National Academy of Sciences of the United States of America
3661:
Proceedings of the
National Academy of Sciences of the United States of America
2742:
Proceedings of the
National Academy of Sciences of the United States of America
2320:
Proceedings of the
National Academy of Sciences of the United States of America
6483:
6402:
6392:
6280:
5391:
5370:
5136:
5073:
5068:
5063:
5043:
5018:
5006:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4814:
4696:
4685:
4671:
4287:
3825:"Ankyrin-based targeting pathway regulates human sinoatrial node automaticity"
3545:
1828:
1761:
1675:
1622:
1599:
1524:
1409:
1299:
1240:
1232:
146:
3058:
2851:"Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line"
6312:
6302:
6262:
6100:
6095:
6090:
5448:
5428:
5083:
5078:
5058:
5053:
5048:
5038:
4947:
4851:
4785:
3980:
3790:
3681:
2918:
2813:
2762:
2340:
1659:
1603:
1575:
1543:
1539:
1488:
1400:
may also be a potential treatment strategy. These mice also display several
1330:
1259:, suggesting that ankyrin-B plays a specifically adapted functional role in
1168:
633:
154:
4084:
4040:
4031:
4014:
3999:
3948:
3899:
3850:
3809:
3750:
3700:
3641:
3597:
3553:
3518:
3461:
3412:
3342:
3323:
3282:
3233:
3166:
3115:
3066:
3021:
2986:
2937:
2886:
2867:
2832:
2781:
2722:
2713:
2696:
2681:
2624:
2580:
2545:
2496:
2447:
2438:
2421:
2403:
2394:
2377:
2359:
2256:
2200:
2191:
2174:
2154:
2146:
2119:
2070:
2037:"Alternative splicing: a key mechanism for ankyrin-B functional diversity?"
2021:
1251:. Though ubiquitously expressed, ankyrin-B shows high expression levels in
17:
4133:
3841:
3824:
3377:
Wolf RM, Mitchell CC, Christensen MD, Mohler PJ, Hund TJ (November 2010).
2478:
2292:
1919:
1756:. Mechanistic studies on effects of these mutations in mice showed severe
6426:
6387:
6319:
6292:
6159:
6147:
6022:
6017:
5458:
5453:
5375:
4809:
4804:
4666:
3864:
Glukhov AV, Fedorov VV, Anderson ME, Mohler PJ, Efimov IR (August 2010).
2003:
1961:
1468:
1248:
1108:
755:
3589:
2616:
1936:
1734:
and transporters. Additional mechanistic studies have shown that atrial
1119:
6453:
6407:
6297:
6227:
6196:
6126:
6121:
6085:
6080:
6075:
6042:
6012:
6007:
6002:
5997:
5682:
5614:
5609:
5604:
5599:
5594:
5486:
5423:
4911:
4856:
4797:
4780:
4741:
4227:
4174:
4164:
3443:
2284:
1838:
1792:
1788:
1691:
1663:
1492:
1445:
1433:
1373:
1338:
1272:
1228:
1224:
1216:
1145:
741:
698:
389:
positive regulation of potassium ion transmembrane transporter activity
3264:
2797:"Ankyrin-B regulates Kir6.2 membrane expression and function in heart"
1651:. Intense investigation has been carried out regarding the linking of
95:
91:
87:
41:
6372:
6354:
6349:
6344:
6339:
6329:
6164:
6057:
6052:
6037:
6032:
5944:
5890:
5855:
5830:
5825:
5820:
5815:
5805:
5800:
5790:
5775:
5770:
5652:
5647:
5642:
5554:
5544:
5524:
5509:
5504:
5499:
5494:
5360:
5131:
5126:
4883:
4549:
4544:
4534:
4312:
3131:"A failure to adapt: ankyrins in congenital and acquired arrhythmias"
2795:
Li J, Kline CF, Hund TJ, Anderson ME, Mohler PJ (10 September 2010).
1818:
1813:
1595:
1429:
1388:; effects that were rescued by transfection of ankyrin-B. Effects on
1381:
1362:
1089:
655:
584:
regulation of ventricular cardiac muscle cell membrane repolarization
454:
positive regulation of calcium ion transmembrane transporter activity
3657:"A cardiac arrhythmia syndrome caused by loss of ankyrin-B function"
1317:. Further studies have shown that the beta-hairpin loops within the
1155:. Ankyrin-2 is ubiquitously expressed, but shows high expression in
2461:
Tuvia S, Buhusi M, Davis L, Reedy M, Bennett V (29 November 1999).
2035:
van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH (December 2008).
1598:, which is required for proper localization and functioning of the
1507:, which is clinically important because elevated expression of the
1191:. Alterations in ankyrin-2 expression levels are observed in human
6397:
6169:
6152:
5989:
5984:
5974:
5969:
5934:
5924:
5914:
5899:
5880:
5870:
5865:
5850:
5845:
5840:
5835:
5810:
5795:
5785:
5780:
5765:
5760:
5740:
5735:
5730:
5725:
5720:
5715:
5710:
5705:
5700:
5695:
5690:
5662:
5657:
5624:
5619:
5589:
5584:
5564:
5559:
5539:
5529:
5444:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5226:
5201:
5196:
5191:
5186:
5181:
5176:
5156:
5151:
5146:
5141:
5121:
5116:
4826:
4756:
4705:
4702:
4699:
4691:
4680:
4677:
4674:
4659:
4654:
4649:
4644:
4616:
4606:
4591:
4524:
4514:
4494:
4469:
4464:
4449:
4439:
4434:
4429:
4424:
4419:
4414:
4399:
4353:
4348:
4343:
4333:
4328:
4323:
4302:
4297:
4292:
4282:
4269:
1833:
1823:
1808:
1591:
1563:
1377:
1527:
membranes; this interaction is also important in the response of
618:
614:
404:
regulation of cardiac muscle contraction by calcium ion signaling
6498:
6493:
6488:
6448:
6419:
6334:
6211:
6206:
6201:
6105:
5755:
5750:
5745:
5672:
5667:
5534:
5416:
5411:
5406:
4866:
4861:
4819:
4732:
4722:
4717:
4611:
4601:
4596:
4586:
4576:
4571:
4566:
4561:
4484:
4409:
4404:
4394:
4389:
4384:
4379:
4374:
4369:
3870:
American
Journal of Physiology. Heart and Circulatory Physiology
3481:
American
Journal of Physiology. Heart and Circulatory Physiology
3383:
American Journal of Physiology. Heart and Circulatory Physiology
2133:
Mohler PJ, Gramolini AO, Bennett V (15 April 2002). "Ankyrins".
2084:
Cunha SR, Le Scouarnec S, Schott JJ, Mohler PJ (December 2008).
1618:
1606:
structures, as well as protection from exercise-induced injury.
1437:
1389:
1385:
1280:
1276:
1203:
Ankyrin-B protein is around 220 kDa, with several isoforms. The
1152:
142:
4200:
4057:
Ayalon G, Davis JQ, Scotland PB, Bennett V (26 December 2008).
1635:
which can be described as an atypical arrhythmia syndrome with
1894:"Mapping of a gene for long QT syndrome to chromosome 4q25-27"
1730:
mutations was the abnormal coordination of a panel of related
1321:
domain of ankyrin-B are required for the interaction with the
1187:; mutations have also been associated to a lesser degree with
1937:"ANK2 ankyrin 2 [Homo sapiens (human)] - Gene - NCBI"
429:
regulation of release of sequestered calcium ion into cytosol
4159:
Overview of all the structural information available in the
559:
regulation of calcium ion transmembrane transporter activity
519:
membrane depolarization during SA node cell action potential
1621:
have been associated with a dominantly-inherited, cardiac
569:
regulation of atrial cardiac muscle cell action potential
474:
endoplasmic reticulum to Golgi vesicle-mediated transport
524:
atrial cardiac muscle cell to AV node cell communication
514:
SA node cell to atrial cardiac muscle cell communication
129:, ANK-2, LQT4, brank-2, ankyrin 2, neuronal, ankyrin 2
1962:"Protein sequences of human ANK2 (Uniprot ID Q01484)"
1752:
mutations have also been identified in patients with
1418:
catecholaminergic polymorphic ventricular tachycardia
2173:
Mohler PJ, Gramolini AO, Bennett V (22 March 2002).
1451:
It is now becoming clear that ankyrin-B exists in a
6466:
6365:
6271:
6226:
6135:
6114:
6066:
5889:
5681:
5633:
5485:
5471:
5437:
5384:
5353:
5333:
5212:
5094:
4925:
4907:
4896:
4839:
4632:
4311:
4268:
4259:
4245:
4238:
2646:Camors E, Mohler PJ, Bers DM, Despa S (June 2012).
1538:Ankyrin-B has also been identified to associate at
1056:
843:
819:
790:
4013:Mohler PJ, Yoon W, Bennett V (17 September 2004).
2695:Cunha SR, Bhasin N, Mohler PJ (16 February 2007).
1231:which is composed of three structural domains: an
1376:release, as well as abnormal distribution of the
2219:Mohler PJ, Davis JQ, Bennett V (December 2005).
1211:is also transcriptionally regulated via over 30
444:ventricular cardiac muscle cell action potential
1706:was not a consistent clinical manifestation of
27:Protein-coding gene in the species Homo sapiens
2951:Hashemi SM, Hund TJ, Mohler PJ (August 2009).
549:regulation of heart rate by cardiac conduction
424:positive regulation of potassium ion transport
399:positive regulation of cation channel activity
4212:
4052:
4050:
2844:
2842:
2415:
2413:
2371:
2369:
2214:
2212:
2210:
2168:
2166:
2164:
534:protein localization to endoplasmic reticulum
479:regulation of cardiac muscle cell contraction
8:
2957:Journal of Molecular and Cellular Cardiology
2652:Journal of Molecular and Cellular Cardiology
2090:Journal of Molecular and Cellular Cardiology
2041:Journal of Molecular and Cellular Cardiology
1873:
1871:
1558:and harbors key residues for modulating the
579:positive regulation of calcium ion transport
509:sarcoplasmic reticulum calcium ion transport
3002:Journal of Cardiovascular Electrophysiology
1398:Ca2+/calmodulin-dependent protein kinase II
1394:Ca2+/calmodulin-dependent protein kinase II
1392:specifically were also rescued by a potent
1325:, and a reduction of ankyrin-B in neonatal
1255:, and is expressed 10-fold lower levels in
544:regulation of SA node cell action potential
504:atrial cardiac muscle cell action potential
5482:
4922:
4904:
4265:
4256:
4242:
4219:
4205:
4197:
4184:United States National Library of Medicine
1519:. Ankyrin-B forms a membrane complex with
1298:proteins. One study showed that the death/
840:
629:
174:
76:
4152:at the U.S. National Library of Medicine
4123:
4074:
4030:
3989:
3979:
3938:
3889:
3840:
3799:
3789:
3740:
3690:
3680:
3508:
3451:
3402:
3313:
3272:
3223:
3213:
3156:
3146:
3105:
2976:
2927:
2917:
2876:
2866:
2822:
2812:
2771:
2761:
2712:
2671:
2535:
2486:
2437:
2393:
2349:
2339:
2246:
2236:
2190:
2109:
2060:
2011:
1909:
1440:, which results in a higher frequency of
1396:inhibitor, suggesting that inhibition of
232:phosphorylation-dependent protein binding
4182:This article incorporates text from the
4106:Davis JQ, Bennett V (10 November 1984).
2953:"Cardiac ankyrins in health and disease"
2849:Cunha SR, Mohler PJ (14 November 2008).
1772:variants exhibited greater maximum left
1670:was found to cause dominantly-inherited
529:regulation of cardiac muscle contraction
3046:Expert Review of Cardiovascular Therapy
1879:"Entrez Gene: ANK2 ankyrin 2, neuronal"
1849:
1475:that are distinct from dyads formed by
594:protein localization to plasma membrane
3359:
3348:
1742:, which can be explained by decreased
1684:inositol-1,4,5-trisphosphate receptors
1378:sarcomplasmic reticular calcium ATPase
1175:cause a dominantly-inherited, cardiac
489:positive regulation of gene expression
212:structural constituent of cytoskeleton
192:protein-macromolecule adaptor activity
31:
1931:
1929:
1436:and enhances the coupled openings of
1227:family of proteins, and is a modular
7:
3302:Circulation: Cardiovascular Genetics
494:protein localization to cell surface
4112:The Journal of Biological Chemistry
4019:The Journal of Biological Chemistry
3968:The Journal of Biological Chemistry
2906:The Journal of Biological Chemistry
2855:The Journal of Biological Chemistry
2801:The Journal of Biological Chemistry
2701:The Journal of Biological Chemistry
2426:The Journal of Biological Chemistry
2382:The Journal of Biological Chemistry
2179:The Journal of Biological Chemistry
1215:events with variable expression of
409:regulation of calcium ion transport
1148:which in humans is encoded by the
1053:
816:
787:
765:
746:
722:
703:
679:
660:
288:intracellular anatomical structure
25:
3733:10.1161/circulationaha.111.023986
3158:10.1161/circulationaha.106.675389
3107:10.1161/circulationaha.106.656512
1744:voltage-dependent calcium channel
1738:lacking ankyrin-B have shortened
1345:is required for normal levels of
394:protein localization to organelle
202:transmembrane transporter binding
4847:Wiskott–Aldrich syndrome protein
3129:Tomaselli GF (30 January 2007).
3014:10.1111/j.1540-8167.2006.00540.x
1521:ATP-sensitive potassium channels
1471:within discrete microdomains of
484:protein localization to T-tubule
449:cellular calcium ion homeostasis
40:
6068:Microtubule organising proteins
3315:10.1161/circgenetics.108.792192
1335:inositol trisphosphate receptor
1323:inositol trisphosphate receptor
1304:inositol trisphosphate receptor
1223:. Ankyrin-B is a member of the
414:regulation of protein stability
1720:inositol triphosphate receptor
1465:inositol triphosphate receptor
1355:inositol triphosphate receptor
469:protein localization to M-band
1:
6115:Microtubule severing proteins
4125:10.1016/S0021-9258(18)90728-3
3534:Heart, Lung & Circulation
1271:Ankyrin-B is a member of the
434:SA node cell action potential
4775:actin depolymerizing factors
3931:10.1136/heartjnl-2014-306387
3215:10.1371/journal.pone.0001051
2238:10.1371/journal.pbio.0030423
6544:Genes on human chromosome 4
6253:Plakoglobin (gamma catenin)
3882:10.1152/ajpheart.00756.2009
3823:Hund TJ, Mohler PJ (2008).
3634:10.1016/j.hrthm.2005.07.026
3501:10.1152/ajpheart.00734.2012
3395:10.1152/ajpheart.00503.2010
2969:10.1016/j.yjmcc.2009.04.010
2664:10.1016/j.yjmcc.2012.02.010
2573:10.1016/j.hrthm.2012.09.011
2528:10.1016/j.hrthm.2012.08.026
2467:The Journal of Cell Biology
2102:10.1016/j.yjmcc.2008.08.005
2053:10.1016/j.yjmcc.2008.08.016
1797:ischemia reperfusion injury
1766:hypertrophic cardiomyopathy
1235:domain containing multiple
1189:hypertrophic cardiomyopathy
499:paranodal junction assembly
298:basolateral plasma membrane
6560:
4076:10.1016/j.cell.2008.10.018
1570:is also key for targeting
1535:and metabolic regulation.
1341:) folds as an amphipathic
459:nervous system development
6509:
3546:10.1016/j.hlc.2014.09.013
3428:"LQTS gene LOVD database"
1858:"Human PubMed Reference:"
1647:, arrhythmia and risk of
1631:, type 4, also known as
1477:dihydropyridine receptors
1404:abnormalities, including
1171:structures. Mutations in
1123:
1118:
1114:
1107:
1088:
1073:
1060:
867:
836:
823:
794:
783:
772:
768:
753:
749:
740:
729:
725:
710:
706:
697:
686:
682:
667:
663:
654:
639:
632:
628:
612:
589:cytoskeleton organization
554:atrial septum development
539:response to methylmercury
177:
173:
136:
133:
123:
116:
111:
84:
79:
62:
57:
52:
48:
39:
34:
6479:Prokaryotic cytoskeleton
4154:Medical Subject Headings
3059:10.1586/14779072.4.4.477
1712:sodium calcium exchanger
1680:sodium-calcium exchanger
1582:signaling paradigms. In
1509:sodium calcium exchanger
1501:sodium calcium exchanger
1461:sodium calcium exchanger
1365:binding to this region.
1347:sodium-calcium exchanger
464:regulation of heart rate
3981:10.1074/jbc.m112.368415
3829:Channels (Austin, Tex.)
3791:10.1073/pnas.0805500105
3682:10.1073/pnas.0402546101
2919:10.1074/jbc.m110.187831
2814:10.1074/jbc.m110.147868
2763:10.1073/pnas.0907138106
2341:10.1073/pnas.0403711101
2135:Journal of Cell Science
1992:Cardiovascular Research
1785:reactive oxygen species
1716:sodium potassium ATPase
1511:is a factor related to
1457:sodium potassium ATPase
1351:sodium potassium ATPase
4032:10.1074/jbc.m406018200
3358:Cite journal requires
2868:10.1074/jbc.m806050200
2714:10.1074/jbc.m607096200
2439:10.1074/jbc.m401296200
2395:10.1074/jbc.m313979200
2192:10.1074/jbc.m110958200
2147:10.1242/jcs.115.8.1565
1779:In patients with both
1754:sinus node dysfunction
1698:. Further analysis in
1694:handling resulting in
1572:protein phosphatase 2A
1562:between ankyrin-B and
1483:. The human ankyrin-B
1467:which is localized in
1361:, and is regulated by
308:apical plasma membrane
227:protein kinase binding
63:Human UniProt search:
5099:(hard alpha-keratins)
4930:(soft alpha-keratins)
3842:10.4161/chan.2.6.7220
2479:10.1083/jcb.147.5.995
1610:Clinical significance
574:T-tubule organization
439:protein stabilization
263:postsynaptic membrane
6514:cytoskeletal defects
6474:Major sperm proteins
1941:www.ncbi.nlm.nih.gov
1649:sudden cardiac death
1453:biomolecular complex
1426:sudden cardiac death
1402:electrophysiological
1275:family of proteins.
1213:alternative splicing
373:axon initial segment
80:List of PDB id codes
53:Available structures
4927:Epithelial keratins
4173:(Ankyrin-2) at the
4150:ANK2+protein,+human
3782:2008PNAS..10515617L
3673:2004PNAS..101.9137M
3590:10.1038/nature01335
3582:2003Natur.421..634M
3493:2013BpJ...104S.287W
3206:2007PLoSO...2.1051M
2754:2009PNAS..10616669K
2617:10.1038/nature01335
2609:2003Natur.421..634M
2332:2004PNAS..10117533M
1760:and variability in
1641:atrial fibrillation
1481:ryanodine receptors
1438:ryanodine receptors
1390:ryanodine receptors
1386:ryanodine receptors
1185:sick sinus syndrome
564:signal transduction
4186:, which is in the
3444:10.1002/humu.21341
2285:10.1038/ng0696-214
2004:10.1093/cvr/cvv184
1688:transverse tubules
1633:ankyrin-B syndrome
1625:syndrome known as
1540:sarcomeric M-lines
1308:ryanodine receptor
1181:long QT syndrome 4
1179:syndrome known as
382:Biological process
363:recycling endosome
241:Cellular component
185:Molecular function
6521:
6520:
6462:
6461:
6222:
6221:
5467:
5466:
5349:
5348:
4892:
4891:
4835:
4834:
3265:10.2217/pgs.09.67
2432:(24): 25798–804.
2185:(12): 10599–607.
1898:Am. J. Hum. Genet
1740:action potentials
1614:Mutations in the
1310:localization and
1131:
1130:
1127:
1126:
1103:
1102:
1069:
1068:
1050:
1049:
832:
831:
813:
812:
779:
778:
762:
761:
736:
735:
719:
718:
693:
692:
676:
675:
624:
623:
604:protein transport
318:neuron projection
273:intercalated disc
107:
106:
103:
102:
16:(Redirected from
6551:
5483:
4923:
4905:
4266:
4257:
4243:
4221:
4214:
4207:
4198:
4138:
4137:
4127:
4103:
4097:
4096:
4078:
4054:
4045:
4044:
4034:
4025:(38): 40185–93.
4010:
4004:
4003:
3993:
3983:
3974:(36): 30268–81.
3959:
3953:
3952:
3942:
3910:
3904:
3903:
3893:
3861:
3855:
3854:
3844:
3820:
3814:
3813:
3803:
3793:
3776:(40): 15617–22.
3761:
3755:
3754:
3744:
3711:
3705:
3704:
3694:
3684:
3652:
3646:
3645:
3616:
3610:
3609:
3564:
3558:
3557:
3529:
3523:
3522:
3512:
3472:
3466:
3465:
3455:
3438:(11): E1801–10.
3423:
3417:
3416:
3406:
3374:
3368:
3367:
3361:
3356:
3354:
3346:
3334:
3328:
3327:
3317:
3293:
3287:
3286:
3276:
3253:Pharmacogenomics
3244:
3238:
3237:
3227:
3217:
3185:
3179:
3178:
3160:
3150:
3126:
3120:
3119:
3109:
3085:
3079:
3078:
3040:
3034:
3033:
2997:
2991:
2990:
2980:
2948:
2942:
2941:
2931:
2921:
2897:
2891:
2890:
2880:
2870:
2861:(46): 31968–80.
2846:
2837:
2836:
2826:
2816:
2807:(37): 28723–30.
2792:
2786:
2785:
2775:
2765:
2748:(39): 16669–74.
2733:
2727:
2726:
2716:
2692:
2686:
2685:
2675:
2643:
2637:
2636:
2591:
2585:
2584:
2556:
2550:
2549:
2539:
2507:
2501:
2500:
2490:
2458:
2452:
2451:
2441:
2417:
2408:
2407:
2397:
2373:
2364:
2363:
2353:
2343:
2311:
2305:
2304:
2267:
2261:
2260:
2250:
2240:
2216:
2205:
2204:
2194:
2170:
2159:
2158:
2141:(Pt 8): 1565–6.
2130:
2124:
2123:
2113:
2081:
2075:
2074:
2064:
2032:
2026:
2025:
2015:
1983:
1977:
1976:
1974:
1972:
1958:
1952:
1951:
1949:
1947:
1933:
1924:
1923:
1913:
1889:
1883:
1882:
1875:
1866:
1865:
1854:
1787:, intracellular
1776:wall thickness.
1768:, patients with
1704:long QT syndrome
1674:type 4, cardiac
1672:long QT syndrome
1645:conduction block
1628:long QT syndrome
1533:cardiac ischemia
1167:, as well as in
1116:
1115:
1099:
1084:
1079:
1064:
1054:
1045:
841:
837:RefSeq (protein)
827:
817:
808:
788:
766:
747:
723:
704:
680:
661:
630:
197:spectrin binding
175:
169:
167:ANK2 - orthologs
128:
121:
98:
77:
71:
50:
49:
44:
32:
21:
6559:
6558:
6554:
6553:
6552:
6550:
6549:
6548:
6524:
6523:
6522:
6517:
6505:
6458:
6361:
6267:
6218:
6131:
6110:
6062:
5885:
5677:
5629:
5475:
5463:
5433:
5380:
5345:
5329:
5213:Ungrouped alpha
5208:
5098:
5090:
4929:
4915:
4909:
4899:
4888:
4831:
4628:
4307:
4249:
4234:
4225:
4194:
4146:
4141:
4118:(21): 13550–9.
4105:
4104:
4100:
4069:(7): 1189–200.
4056:
4055:
4048:
4012:
4011:
4007:
3961:
3960:
3956:
3912:
3911:
3907:
3863:
3862:
3858:
3822:
3821:
3817:
3763:
3762:
3758:
3727:(11): 1212–22.
3713:
3712:
3708:
3667:(24): 9137–42.
3654:
3653:
3649:
3628:(11): 1218–23.
3618:
3617:
3613:
3576:(6923): 634–9.
3566:
3565:
3561:
3531:
3530:
3526:
3487:(9): H1253–66.
3474:
3473:
3469:
3425:
3424:
3420:
3389:(5): H1505–14.
3376:
3375:
3371:
3357:
3347:
3336:
3335:
3331:
3295:
3294:
3290:
3246:
3245:
3241:
3187:
3186:
3182:
3148:10.1.1.533.2965
3128:
3127:
3123:
3087:
3086:
3082:
3042:
3041:
3037:
2999:
2998:
2994:
2950:
2949:
2945:
2899:
2898:
2894:
2848:
2847:
2840:
2794:
2793:
2789:
2735:
2734:
2730:
2694:
2693:
2689:
2645:
2644:
2640:
2603:(6923): 634–9.
2593:
2592:
2588:
2558:
2557:
2553:
2522:(12): 2034–41.
2509:
2508:
2504:
2473:(5): 995–1008.
2460:
2459:
2455:
2419:
2418:
2411:
2388:(13): 12980–7.
2375:
2374:
2367:
2326:(50): 17533–8.
2313:
2312:
2308:
2273:Nature Genetics
2269:
2268:
2264:
2218:
2217:
2208:
2172:
2171:
2162:
2132:
2131:
2127:
2083:
2082:
2078:
2034:
2033:
2029:
1985:
1984:
1980:
1970:
1968:
1960:
1959:
1955:
1945:
1943:
1935:
1934:
1927:
1891:
1890:
1886:
1877:
1876:
1869:
1856:
1855:
1851:
1847:
1805:
1612:
1584:skeletal muscle
1580:phosphorylation
1552:skeletal muscle
1269:
1257:skeletal muscle
1245:ankyrin repeats
1237:ankyrin repeats
1201:
1120:View/Edit Human
1097:
1082:
1077:
1074:Location (UCSC)
1062:
1041:
1037:
1033:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1001:
997:
993:
989:
985:
981:
977:
973:
969:
965:
961:
957:
953:
949:
945:
941:
937:
933:
929:
925:
921:
917:
913:
909:
905:
901:
897:
893:
889:
885:
881:
877:
873:
869:
863:
859:
855:
851:
847:
825:
804:
800:
796:
713:ENSG00000145362
608:
377:
368:plasma membrane
236:
217:protein binding
137:
124:
117:
86:
64:
28:
23:
22:
15:
12:
11:
5:
6557:
6555:
6547:
6546:
6541:
6539:Human proteins
6536:
6526:
6525:
6519:
6518:
6510:
6507:
6506:
6504:
6503:
6502:
6501:
6496:
6491:
6486:
6476:
6470:
6468:
6464:
6463:
6460:
6459:
6457:
6456:
6451:
6446:
6445:
6444:
6439:
6429:
6424:
6423:
6422:
6412:
6411:
6410:
6405:
6400:
6395:
6390:
6385:
6380:
6378:Corneodesmosin
6369:
6367:
6363:
6362:
6360:
6359:
6358:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6317:
6316:
6315:
6310:
6305:
6295:
6290:
6289:
6288:
6277:
6275:
6269:
6268:
6266:
6265:
6260:
6255:
6250:
6249:
6248:
6238:
6232:
6230:
6224:
6223:
6220:
6219:
6217:
6216:
6215:
6214:
6209:
6204:
6194:
6193:
6192:
6187:
6182:
6177:
6172:
6162:
6157:
6156:
6155:
6145:
6139:
6137:
6133:
6132:
6130:
6129:
6124:
6118:
6116:
6112:
6111:
6109:
6108:
6103:
6098:
6093:
6088:
6083:
6078:
6072:
6070:
6064:
6063:
6061:
6060:
6055:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5993:
5992:
5987:
5982:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5942:
5937:
5932:
5927:
5922:
5917:
5912:
5907:
5902:
5895:
5893:
5887:
5886:
5884:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5818:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5698:
5693:
5687:
5685:
5679:
5678:
5676:
5675:
5670:
5665:
5660:
5655:
5650:
5645:
5639:
5637:
5631:
5630:
5628:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5491:
5489:
5480:
5469:
5468:
5465:
5464:
5462:
5461:
5456:
5451:
5445:Nuclear lamins
5441:
5439:
5435:
5434:
5432:
5431:
5426:
5421:
5420:
5419:
5414:
5409:
5399:
5394:
5388:
5386:
5382:
5381:
5379:
5378:
5373:
5368:
5363:
5357:
5355:
5351:
5350:
5347:
5346:
5344:
5343:
5337:
5335:
5331:
5330:
5328:
5327:
5326:
5325:
5320:
5315:
5310:
5305:
5300:
5295:
5290:
5285:
5280:
5267:
5266:
5265:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5216:
5214:
5210:
5209:
5207:
5206:
5205:
5204:
5199:
5194:
5189:
5184:
5179:
5162:
5161:
5160:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5102:
5100:
5092:
5091:
5089:
5088:
5087:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5024:
5023:
5022:
5021:
5011:
5010:
5009:
4997:
4996:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4950:
4933:
4931:
4920:
4902:
4894:
4893:
4890:
4889:
4887:
4886:
4881:
4876:
4875:
4874:
4869:
4864:
4854:
4849:
4843:
4841:
4837:
4836:
4833:
4832:
4830:
4829:
4824:
4823:
4822:
4817:
4807:
4802:
4801:
4800:
4795:
4794:
4793:
4788:
4771:
4769:Arp2/3 complex
4766:
4765:
4764:
4759:
4754:
4749:
4738:
4737:
4736:
4735:
4730:
4725:
4720:
4710:
4709:
4708:
4694:
4683:
4664:
4663:
4662:
4657:
4652:
4647:
4636:
4634:
4630:
4629:
4627:
4626:
4625:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4554:
4553:
4552:
4547:
4539:
4538:
4537:
4529:
4528:
4527:
4519:
4518:
4517:
4512:
4504:
4503:
4502:
4497:
4489:
4488:
4487:
4479:
4478:
4477:
4472:
4467:
4459:
4458:
4457:
4452:
4444:
4443:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4364:
4363:
4362:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4317:
4315:
4309:
4308:
4306:
4305:
4300:
4295:
4290:
4285:
4280:
4274:
4272:
4263:
4254:
4247:Microfilaments
4240:
4236:
4235:
4226:
4224:
4223:
4216:
4209:
4201:
4179:
4178:
4157:
4145:
4144:External links
4142:
4140:
4139:
4098:
4046:
4005:
3954:
3925:(4): 294–301.
3905:
3876:(2): H482–91.
3856:
3815:
3756:
3706:
3647:
3611:
3559:
3524:
3467:
3432:Human Mutation
3418:
3369:
3360:|journal=
3329:
3288:
3259:(6): 1043–53.
3239:
3180:
3121:
3080:
3035:
3008:(10): 1153–9.
2992:
2943:
2892:
2838:
2787:
2728:
2707:(7): 4875–83.
2687:
2638:
2586:
2567:(12): 2042–3.
2551:
2502:
2453:
2409:
2365:
2306:
2262:
2206:
2160:
2125:
2076:
2027:
1978:
1953:
1925:
1904:(5): 1114–22.
1884:
1867:
1848:
1846:
1843:
1842:
1841:
1836:
1831:
1826:
1821:
1816:
1811:
1804:
1801:
1736:cardiomyocytes
1724:cardiomyocytes
1611:
1608:
1556:cardiac muscle
1548:cardiac muscle
1529:cardiomyocytes
1505:cardiomyocytes
1485:arrhythmogenic
1473:cardiomyocytes
1442:calcium sparks
1370:Cardiomyocytes
1359:cardiomyocytes
1327:cardiomyocytes
1319:ankyrin repeat
1289:cardiomyocytes
1268:
1265:
1261:cardiac muscle
1253:cardiac muscle
1221:cardiac muscle
1200:
1197:
1165:cardiomyocytes
1157:cardiac muscle
1136:also known as
1129:
1128:
1125:
1124:
1122:
1112:
1111:
1105:
1104:
1101:
1100:
1095:
1093:
1086:
1085:
1080:
1075:
1071:
1070:
1067:
1066:
1058:
1057:
1051:
1048:
1047:
865:
864:
838:
834:
833:
830:
829:
821:
820:
814:
811:
810:
792:
791:
785:
781:
780:
777:
776:
770:
769:
763:
760:
759:
751:
750:
744:
738:
737:
734:
733:
727:
726:
720:
717:
716:
708:
707:
701:
695:
694:
691:
690:
684:
683:
677:
674:
673:
665:
664:
658:
652:
651:
646:
641:
637:
636:
626:
625:
622:
621:
610:
609:
607:
606:
601:
596:
591:
586:
581:
576:
571:
566:
561:
556:
551:
546:
541:
536:
531:
526:
521:
516:
511:
506:
501:
496:
491:
486:
481:
476:
471:
466:
461:
456:
451:
446:
441:
436:
431:
426:
421:
416:
411:
406:
401:
396:
391:
385:
383:
379:
378:
376:
375:
370:
365:
360:
358:early endosome
355:
350:
345:
340:
335:
330:
325:
320:
315:
310:
305:
300:
295:
290:
285:
280:
275:
270:
265:
260:
255:
250:
244:
242:
238:
237:
235:
234:
229:
224:
222:enzyme binding
219:
214:
209:
207:ATPase binding
204:
199:
194:
188:
186:
182:
181:
171:
170:
135:
131:
130:
122:
114:
113:
109:
108:
105:
104:
101:
100:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6556:
6545:
6542:
6540:
6537:
6535:
6532:
6531:
6529:
6516:
6515:
6508:
6500:
6497:
6495:
6492:
6490:
6487:
6485:
6482:
6481:
6480:
6477:
6475:
6472:
6471:
6469:
6465:
6455:
6452:
6450:
6447:
6443:
6440:
6438:
6435:
6434:
6433:
6430:
6428:
6425:
6421:
6418:
6417:
6416:
6413:
6409:
6406:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6375:
6374:
6371:
6370:
6368:
6364:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6322:
6321:
6318:
6314:
6311:
6309:
6306:
6304:
6301:
6300:
6299:
6296:
6294:
6291:
6287:
6284:
6283:
6282:
6279:
6278:
6276:
6274:
6270:
6264:
6261:
6259:
6258:Delta catenin
6256:
6254:
6251:
6247:
6244:
6243:
6242:
6239:
6237:
6236:Alpha catenin
6234:
6233:
6231:
6229:
6225:
6213:
6210:
6208:
6205:
6203:
6200:
6199:
6198:
6195:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6167:
6166:
6163:
6161:
6158:
6154:
6151:
6150:
6149:
6146:
6144:
6141:
6140:
6138:
6134:
6128:
6125:
6123:
6120:
6119:
6117:
6113:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6084:
6082:
6079:
6077:
6074:
6073:
6071:
6069:
6065:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:cytoplasmic:
5995:
5994:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5966:
5963:
5961:
5958:
5956:
5953:
5951:
5948:
5946:
5943:
5941:
5938:
5936:
5933:
5931:
5928:
5926:
5923:
5921:
5918:
5916:
5913:
5911:
5908:
5906:
5903:
5901:
5897:
5896:
5894:
5892:
5888:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5688:
5686:
5684:
5680:
5674:
5671:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5640:
5638:
5636:
5632:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5492:
5490:
5488:
5484:
5481:
5479:
5474:
5470:
5460:
5457:
5455:
5452:
5450:
5446:
5443:
5442:
5440:
5436:
5430:
5427:
5425:
5422:
5418:
5415:
5413:
5410:
5408:
5405:
5404:
5403:
5402:Neurofilament
5400:
5398:
5395:
5393:
5390:
5389:
5387:
5383:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5358:
5356:
5352:
5342:
5339:
5338:
5336:
5332:
5324:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5279:
5276:
5275:
5274:
5273:
5272:chromosome 12
5269:
5268:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5224:
5223:
5222:
5221:chromosome 17
5218:
5217:
5215:
5211:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5174:
5173:
5172:
5171:chromosome 12
5168:
5164:
5163:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5114:
5113:
5112:
5111:chromosome 17
5108:
5104:
5103:
5101:
5097:
5096:Hair keratins
5093:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5036:
5035:
5034:
5033:chromosome 12
5030:
5026:
5025:
5020:
5017:
5016:
5015:
5012:
5008:
5005:
5004:
5003:
5002:
5001:chromosome 12
4998:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4945:
4944:
4943:
4942:chromosome 17
4939:
4935:
4934:
4932:
4928:
4924:
4921:
4918:
4913:
4906:
4903:
4901:
4898:Intermediate
4895:
4885:
4882:
4880:
4877:
4873:
4870:
4868:
4865:
4863:
4860:
4859:
4858:
4855:
4853:
4850:
4848:
4845:
4844:
4842:
4838:
4828:
4825:
4821:
4818:
4816:
4813:
4812:
4811:
4808:
4806:
4803:
4799:
4796:
4792:
4789:
4787:
4784:
4783:
4782:
4779:
4778:
4777:
4776:
4772:
4770:
4767:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4744:
4743:
4740:
4739:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4715:
4714:
4711:
4707:
4704:
4701:
4698:
4695:
4693:
4690:
4687:
4684:
4682:
4679:
4676:
4673:
4670:
4669:
4668:
4665:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4642:
4641:
4638:
4637:
4635:
4631:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4559:
4558:
4555:
4551:
4548:
4546:
4543:
4542:
4540:
4536:
4533:
4532:
4530:
4526:
4523:
4522:
4520:
4516:
4513:
4511:
4508:
4507:
4505:
4501:
4498:
4496:
4493:
4492:
4490:
4486:
4483:
4482:
4480:
4476:
4473:
4471:
4468:
4466:
4463:
4462:
4460:
4456:
4453:
4451:
4448:
4447:
4445:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4367:
4365:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4321:
4319:
4318:
4316:
4314:
4310:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4275:
4273:
4271:
4267:
4264:
4262:
4258:
4255:
4253:
4248:
4244:
4241:
4237:
4233:
4229:
4222:
4217:
4215:
4210:
4208:
4203:
4202:
4199:
4195:
4192:
4191:
4189:
4188:public domain
4185:
4176:
4172:
4171:
4166:
4162:
4158:
4155:
4151:
4148:
4147:
4143:
4135:
4131:
4126:
4121:
4117:
4113:
4109:
4102:
4099:
4094:
4090:
4086:
4082:
4077:
4072:
4068:
4064:
4060:
4053:
4051:
4047:
4042:
4038:
4033:
4028:
4024:
4020:
4016:
4009:
4006:
4001:
3997:
3992:
3987:
3982:
3977:
3973:
3969:
3965:
3958:
3955:
3950:
3946:
3941:
3936:
3932:
3928:
3924:
3920:
3916:
3909:
3906:
3901:
3897:
3892:
3887:
3883:
3879:
3875:
3871:
3867:
3860:
3857:
3852:
3848:
3843:
3838:
3834:
3830:
3826:
3819:
3816:
3811:
3807:
3802:
3797:
3792:
3787:
3783:
3779:
3775:
3771:
3767:
3760:
3757:
3752:
3748:
3743:
3738:
3734:
3730:
3726:
3722:
3718:
3710:
3707:
3702:
3698:
3693:
3688:
3683:
3678:
3674:
3670:
3666:
3662:
3658:
3651:
3648:
3643:
3639:
3635:
3631:
3627:
3623:
3615:
3612:
3607:
3603:
3599:
3595:
3591:
3587:
3583:
3579:
3575:
3571:
3563:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3528:
3525:
3520:
3516:
3511:
3506:
3502:
3498:
3494:
3490:
3486:
3482:
3478:
3471:
3468:
3463:
3459:
3454:
3449:
3445:
3441:
3437:
3433:
3429:
3422:
3419:
3414:
3410:
3405:
3400:
3396:
3392:
3388:
3384:
3380:
3373:
3370:
3365:
3352:
3344:
3340:
3333:
3330:
3325:
3321:
3316:
3311:
3307:
3303:
3299:
3292:
3289:
3284:
3280:
3275:
3270:
3266:
3262:
3258:
3254:
3250:
3243:
3240:
3235:
3231:
3226:
3221:
3216:
3211:
3207:
3203:
3200:(10): e1051.
3199:
3195:
3191:
3184:
3181:
3176:
3172:
3168:
3164:
3159:
3154:
3149:
3144:
3140:
3136:
3132:
3125:
3122:
3117:
3113:
3108:
3103:
3100:(4): 432–41.
3099:
3095:
3091:
3084:
3081:
3076:
3072:
3068:
3064:
3060:
3056:
3053:(4): 477–85.
3052:
3048:
3047:
3039:
3036:
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
2996:
2993:
2988:
2984:
2979:
2974:
2970:
2966:
2962:
2958:
2954:
2947:
2944:
2939:
2935:
2930:
2925:
2920:
2915:
2912:(9): 7370–8.
2911:
2907:
2903:
2896:
2893:
2888:
2884:
2879:
2874:
2869:
2864:
2860:
2856:
2852:
2845:
2843:
2839:
2834:
2830:
2825:
2820:
2815:
2810:
2806:
2802:
2798:
2791:
2788:
2783:
2779:
2774:
2769:
2764:
2759:
2755:
2751:
2747:
2743:
2739:
2732:
2729:
2724:
2720:
2715:
2710:
2706:
2702:
2698:
2691:
2688:
2683:
2679:
2674:
2669:
2665:
2661:
2658:(6): 1240–8.
2657:
2653:
2649:
2642:
2639:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2602:
2598:
2590:
2587:
2582:
2578:
2574:
2570:
2566:
2562:
2555:
2552:
2547:
2543:
2538:
2533:
2529:
2525:
2521:
2517:
2513:
2506:
2503:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2454:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2416:
2414:
2410:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2372:
2370:
2366:
2361:
2357:
2352:
2347:
2342:
2337:
2333:
2329:
2325:
2321:
2317:
2310:
2307:
2302:
2298:
2294:
2290:
2286:
2282:
2278:
2274:
2266:
2263:
2258:
2254:
2249:
2244:
2239:
2234:
2230:
2226:
2222:
2215:
2213:
2211:
2207:
2202:
2198:
2193:
2188:
2184:
2180:
2176:
2169:
2167:
2165:
2161:
2156:
2152:
2148:
2144:
2140:
2136:
2129:
2126:
2121:
2117:
2112:
2107:
2103:
2099:
2096:(6): 724–34.
2095:
2091:
2087:
2080:
2077:
2072:
2068:
2063:
2058:
2054:
2050:
2047:(6): 709–11.
2046:
2042:
2038:
2031:
2028:
2023:
2019:
2014:
2009:
2005:
2001:
1998:(4): 466–77.
1997:
1993:
1989:
1982:
1979:
1967:
1963:
1957:
1954:
1942:
1938:
1932:
1930:
1926:
1921:
1917:
1912:
1907:
1903:
1899:
1895:
1888:
1885:
1880:
1874:
1872:
1868:
1863:
1859:
1853:
1850:
1844:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1815:
1812:
1810:
1807:
1806:
1802:
1800:
1798:
1794:
1790:
1786:
1782:
1777:
1775:
1771:
1767:
1763:
1759:
1755:
1751:
1747:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1696:extrasystoles
1693:
1690:, as well as
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1658:Initially, a
1656:
1654:
1650:
1646:
1642:
1638:
1634:
1630:
1629:
1624:
1620:
1617:
1609:
1607:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1578:to propagate
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1536:
1534:
1530:
1526:
1522:
1518:
1517:heart failure
1514:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1479:complexed to
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1449:
1447:
1444:and waves of
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1366:
1364:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1315:contractility
1313:
1312:cardiomyocyte
1309:
1305:
1301:
1297:
1292:
1290:
1286:
1282:
1278:
1274:
1266:
1264:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1198:
1196:
1194:
1193:heart failure
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1151:
1147:
1143:
1142:Brain ankyrin
1139:
1135:
1121:
1117:
1113:
1110:
1106:
1096:
1094:
1091:
1087:
1081:
1076:
1072:
1065:
1059:
1055:
1052:
1046:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
992:
988:
984:
980:
976:
972:
968:
964:
960:
956:
952:
948:
944:
940:
936:
932:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
866:
862:
858:
854:
850:
846:
842:
839:
835:
828:
822:
818:
815:
809:
807:
803:
799:
793:
789:
786:
784:RefSeq (mRNA)
782:
775:
771:
767:
764:
758:
757:
752:
748:
745:
743:
739:
732:
728:
724:
721:
715:
714:
709:
705:
702:
700:
696:
689:
685:
681:
678:
672:
671:
666:
662:
659:
657:
653:
650:
647:
645:
642:
638:
635:
631:
627:
620:
616:
611:
605:
602:
600:
597:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
545:
542:
540:
537:
535:
532:
530:
527:
525:
522:
520:
517:
515:
512:
510:
507:
505:
502:
500:
497:
495:
492:
490:
487:
485:
482:
480:
477:
475:
472:
470:
467:
465:
462:
460:
457:
455:
452:
450:
447:
445:
442:
440:
437:
435:
432:
430:
427:
425:
422:
420:
417:
415:
412:
410:
407:
405:
402:
400:
397:
395:
392:
390:
387:
386:
384:
381:
380:
374:
371:
369:
366:
364:
361:
359:
356:
354:
351:
349:
346:
344:
343:mitochondrion
341:
339:
336:
334:
331:
329:
326:
324:
321:
319:
316:
314:
313:membrane raft
311:
309:
306:
304:
301:
299:
296:
294:
293:cell junction
291:
289:
286:
284:
281:
279:
276:
274:
271:
269:
266:
264:
261:
259:
256:
254:
251:
249:
246:
245:
243:
240:
239:
233:
230:
228:
225:
223:
220:
218:
215:
213:
210:
208:
205:
203:
200:
198:
195:
193:
190:
189:
187:
184:
183:
180:
179:Gene ontology
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
132:
127:
120:
115:
110:
99:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
6511:
6307:
6286:Dystroglycan
6241:Beta catenin
5473:Microtubules
5341:Beta-keratin
5270:
5219:
5165:
5105:
5027:
5013:
4999:
4936:
4773:
4640:Tropomodulin
4232:cytoskeleton
4193:
4181:
4180:
4168:
4115:
4111:
4101:
4066:
4062:
4022:
4018:
4008:
3971:
3967:
3957:
3922:
3918:
3908:
3873:
3869:
3859:
3835:(6): 404–6.
3832:
3828:
3818:
3773:
3769:
3759:
3724:
3720:
3709:
3664:
3660:
3650:
3625:
3622:Heart Rhythm
3621:
3614:
3573:
3569:
3562:
3540:(2): e31–4.
3537:
3533:
3527:
3484:
3480:
3470:
3435:
3431:
3421:
3386:
3382:
3372:
3351:cite journal
3332:
3305:
3301:
3291:
3256:
3252:
3242:
3197:
3193:
3183:
3141:(4): 428–9.
3138:
3134:
3124:
3097:
3093:
3083:
3050:
3044:
3038:
3005:
3001:
2995:
2963:(2): 203–9.
2960:
2956:
2946:
2909:
2905:
2895:
2858:
2854:
2804:
2800:
2790:
2745:
2741:
2731:
2704:
2700:
2690:
2655:
2651:
2641:
2600:
2596:
2589:
2564:
2561:Heart Rhythm
2560:
2554:
2519:
2516:Heart Rhythm
2515:
2505:
2470:
2466:
2456:
2429:
2425:
2385:
2381:
2323:
2319:
2309:
2279:(2): 214–8.
2276:
2272:
2265:
2231:(12): e423.
2228:
2225:PLOS Biology
2224:
2182:
2178:
2138:
2134:
2128:
2093:
2089:
2079:
2044:
2040:
2030:
1995:
1991:
1981:
1969:. Retrieved
1965:
1956:
1944:. Retrieved
1940:
1901:
1897:
1887:
1861:
1852:
1803:Interactions
1778:
1769:
1749:
1748:
1732:ion channels
1727:
1707:
1699:
1667:
1666:mutation in
1657:
1652:
1632:
1626:
1615:
1613:
1602:complex and
1586:, ankyrin-B
1537:
1450:
1414:QT intervals
1367:
1329:reduces the
1293:
1285:ion channels
1270:
1208:
1204:
1202:
1172:
1161:ion channels
1149:
1141:
1137:
1133:
1132:
1061:
1043:NP_001341211
1039:NP_001341210
1035:NP_001341209
1031:NP_001341208
1027:NP_001341207
1023:NP_001341206
1019:NP_001341205
1015:NP_001341204
1011:NP_001341203
1007:NP_001341202
1003:NP_001341201
999:NP_001341200
995:NP_001341199
991:NP_001341198
987:NP_001341197
983:NP_001341196
979:NP_001341195
975:NP_001341194
971:NP_001341193
967:NP_001341191
963:NP_001341190
959:NP_001341189
955:NP_001341187
951:NP_001341186
947:NP_001341185
943:NP_001341184
939:NP_001341183
935:NP_001341182
931:NP_001341181
927:NP_001341178
923:NP_001341175
919:NP_001341174
915:NP_001341173
911:NP_001341172
907:NP_001341171
903:NP_001341170
899:NP_001341169
895:NP_001341168
891:NP_001341166
887:NP_001341165
883:NP_001341164
879:NP_001341161
875:NP_001341160
871:NP_001341159
868:
861:NP_001341157
857:NP_001341154
845:NP_001120965
824:
798:NM_001127493
795:
773:
754:
730:
711:
687:
668:
648:
643:
333:cytoskeleton
134:External IDs
85:
29:
6534:Human genes
6432:Plakophilin
6383:Desmoplakin
6143:Tau protein
4917:Cytokeratin
4713:Tropomyosin
4261:Myofilament
3721:Circulation
3308:(2): 93–9.
3135:Circulation
3094:Circulation
1774:ventricular
1758:bradycardia
1637:bradycardia
1596:β2-spectrin
1574:to cardiac
1568:interaction
1560:interaction
1525:sarcolemmal
1497:arrhythmias
1408:, variable
1406:bradycardia
1343:alpha helix
1183:as well as
599:endocytosis
112:Identifiers
18:ANK2 (gene)
6528:Categories
6512:See also:
6484:Crescentin
6403:Periplakin
6393:Envoplakin
6281:Dystrophin
5898:axonemal:
5392:Internexin
5371:Peripherin
1845:References
1814:HDJ1/HSP40
1762:heart rate
1676:arrhythmia
1623:arrhythmia
1600:dystrophin
1592:dynactin-4
1544:costameres
1513:arrhythmia
1487:mutation (
1410:heart rate
1363:HDJ1/HSP40
1300:C-terminal
1241:C-terminal
1233:N-terminal
1177:arrhythmia
1134:Ankyrin-2,
323:sarcolemma
303:Z discdkac
147:HomoloGene
6101:Centrin 3
6096:Centrin 2
6091:Centrin 1
5429:Syncoilin
5334:Not alpha
4900:filaments
4852:Fibrillin
3143:CiteSeerX
1604:costamere
1594:and with
1588:interacts
1469:T-tubules
1455:with the
1331:half-life
1281:ankyrin-3
1277:Ankyrin-1
1199:Structure
1169:costamere
1138:Ankyrin-B
853:NP_066187
849:NP_001139
806:NM_020977
802:NM_001148
634:Orthologs
338:costamere
253:cytoplasm
155:GeneCards
6467:Nonhuman
6427:Vinculin
6388:Dystonin
6320:Spectrin
6293:Utrophin
6273:Membrane
6228:Catenins
6160:Stathmin
6148:Dynactin
6028:DYNC2LI1
6023:DYNC1LI2
6018:DYNC1LI1
5683:Kinesins
5487:Tubulins
5376:Vimentin
4908:Type 1/2
4810:Profilin
4805:Gelsolin
4667:Troponin
4228:Proteins
4093:17268857
4085:19109891
4041:15262991
4000:22778271
3949:25351510
3900:20525877
3851:19098452
3810:18832177
3751:21859974
3701:15178757
3642:16253912
3598:12571597
3554:25456501
3519:23436330
3462:20809527
3413:20729400
3343:20301308
3324:20031550
3283:19530973
3234:17940615
3194:PLOS ONE
3175:18061642
3167:17261669
3116:17242276
3067:16918266
3030:25316469
3022:16800854
2987:19394342
2938:21186323
2887:18782775
2833:20610380
2782:19805355
2723:17178715
2682:22406428
2625:12571597
2581:22982962
2546:23059182
2497:10579720
2448:15075330
2404:14722080
2360:15579534
2301:10946374
2257:16292983
2201:11781319
2155:11950874
2120:18790697
2071:18838078
2022:26109584
1781:ischemic
1564:obscurin
1339:isoforms
1296:chimeric
1267:Function
1249:isoforms
1217:isoforms
1109:Wikidata
613:Sources:
353:endosome
348:lysosome
278:T-tubule
268:membrane
6454:PLEKHA7
6408:Plectin
6373:Plakins
6298:Ankyrin
6197:Dynamin
6127:Spastin
6122:Katanin
6086:CAMSAP3
6081:CAMSAP2
6076:CAMSAP1
6048:DYNLRB2
6043:DYNLRB1
6013:DYNC1I2
6008:DYNC1I1
6003:DYNC2H1
5998:DYNC1H1
5891:Dyneins
5615:TUBGCP6
5610:TUBGCP5
5605:TUBGCP4
5600:TUBGCP3
5595:TUBGCP2
5424:Synemin
5167:type II
5029:type II
4912:Keratin
4857:Filamin
4798:Destrin
4781:Cofilin
4742:Actinin
4313:Myosins
4230:of the
4175:PDBe-KB
4165:UniProt
4134:6092380
3991:3436279
3940:4345808
3891:2930390
3801:2563133
3778:Bibcode
3742:3211046
3669:Bibcode
3606:4429278
3578:Bibcode
3510:3652094
3489:Bibcode
3453:3037562
3404:2993217
3274:2746955
3225:2013943
3202:Bibcode
2978:2745072
2929:3044993
2878:2581558
2824:2937900
2773:2757796
2750:Bibcode
2673:3348355
2633:4429278
2605:Bibcode
2537:3630478
2488:2169334
2328:Bibcode
2293:8640229
2248:1287507
2111:2630508
2062:2606664
2013:4540146
1971:12 July
1966:UniProt
1946:7 March
1920:7485162
1911:1801360
1839:tubulin
1793:calpain
1789:calcium
1692:calcium
1576:M-lines
1566:. This
1446:calcium
1434:calcium
1422:syncope
1412:, long
1374:calcium
1333:of the
1273:ankyrin
1229:protein
1225:ankyrin
1146:protein
1144:, is a
742:UniProt
699:Ensembl
640:Species
619:QuickGO
283:synapse
258:cytosol
119:Aliases
6355:SPTBN5
6350:SPTBN4
6345:SPTBN2
6340:SPTBN1
6330:SPTAN1
6165:Tektin
6058:DYNLT3
6053:DYNLT1
6038:DYNLL2
6033:DYNLL1
5980:DNALI1
5965:DNAH17
5960:DNAH14
5955:DNAH13
5950:DNAH12
5945:DNAH11
5940:DNAH10
5861:KIF26B
5856:KIF26A
5831:KIF21B
5826:KIF21A
5821:KIF20B
5816:KIF20A
5806:KIF18B
5801:KIF18A
5791:KIF16B
5776:KIF13B
5771:KIF13A
5570:TUBB4Q
5555:TUBB2C
5550:TUBB2B
5545:TUBB2A
5525:TUBA4A
5520:TUBA3E
5515:TUBA3D
5510:TUBA3C
5505:TUBA1C
5500:TUBA1B
5495:TUBA1A
5438:Type 5
5397:Nestin
5385:Type 4
5361:Desmin
5354:Type 3
5107:type I
4938:type I
4884:TRIOBP
4550:MYO18B
4545:MYO18A
4541:XVIII
4535:MYO15A
4270:Actins
4170:Q01484
4156:(MeSH)
4132:
4091:
4083:
4039:
3998:
3988:
3947:
3937:
3898:
3888:
3849:
3808:
3798:
3749:
3739:
3699:
3692:428486
3689:
3640:
3604:
3596:
3570:Nature
3552:
3517:
3507:
3460:
3450:
3411:
3401:
3341:
3322:
3281:
3271:
3232:
3222:
3173:
3165:
3145:
3114:
3075:969289
3073:
3065:
3028:
3020:
2985:
2975:
2936:
2926:
2885:
2875:
2831:
2821:
2780:
2770:
2721:
2680:
2670:
2631:
2623:
2597:Nature
2579:
2544:
2534:
2495:
2485:
2446:
2402:
2358:
2351:536011
2348:
2299:
2291:
2255:
2245:
2199:
2153:
2118:
2108:
2069:
2059:
2020:
2010:
1918:
1908:
1819:SPTBN1
1682:, and
1430:sodium
1424:, and
1384:, and
1382:SERCA2
1140:, and
1092:search
1090:PubMed
756:Q01484
656:Entrez
328:A band
248:M band
143:106410
6415:Talin
6398:MACF1
6366:Other
6325:SPTA1
6190:TEKT5
6185:TEKT4
6180:TEKT3
6175:TEKT2
6170:TEKT1
6153:DCTN1
6136:Other
5990:DNAL4
5985:DNAL1
5975:DNAI2
5970:DNAI1
5935:DNAH9
5930:DNAH8
5925:DNAH7
5920:DNAH6
5915:DNAH5
5910:DNAH3
5905:DNAH2
5900:DNAH1
5881:KIFC3
5876:KIFC2
5871:KIFC1
5866:KIF27
5851:KIF25
5846:KIF24
5841:KIF23
5836:KIF22
5811:KIF19
5796:KIF17
5786:KIF15
5781:KIF14
5766:KIF12
5761:KIF11
5741:KIF5C
5736:KIF5B
5731:KIF5A
5726:KIF4B
5721:KIF4A
5716:KIF3C
5711:KIF3B
5706:KIF2C
5701:KIF2A
5696:KIF1B
5691:KIF1A
5663:MAP1B
5658:MAP1A
5625:TUBE1
5620:TUBD1
5590:TUBG2
5585:TUBG1
5580:TUBB8
5575:TUBB6
5565:TUBB4
5560:TUBB3
5540:TUBB1
5530:TUBA8
4879:Espin
4840:Other
4827:Titin
4633:Other
4622:MYLL1
4617:MYLK2
4607:MYLIP
4592:MYL6B
4525:MYO10
4515:MYO9B
4510:MYO9A
4500:MYO7B
4495:MYO7A
4475:MYO5C
4470:MYO5B
4465:MYO5A
4455:MYO3B
4450:MYO3A
4440:MYH16
4435:MYH15
4430:MYH14
4425:MYH13
4420:MYH11
4415:MYH10
4400:MYH7B
4359:MYO1H
4354:MYO1G
4349:MYO1F
4344:MYO1E
4339:MYO1D
4334:MYO1C
4329:MYO1B
4324:MYO1A
4239:Human
4089:S2CID
3919:Heart
3602:S2CID
3171:S2CID
3071:S2CID
3026:S2CID
2629:S2CID
2297:S2CID
1834:DCTN4
1824:OBSCN
1809:ITPR1
1590:with
649:Mouse
644:Human
615:Amigo
151:81655
6499:ParM
6494:MreB
6489:FtsZ
6449:ACF7
6442:PKP2
6437:PKP1
6420:TLN1
6335:SPTB
6313:ANK3
6308:ANK2
6303:ANK1
6212:DNM3
6207:DNM2
6202:DNM1
6106:PCM1
5756:KIF9
5751:KIF7
5746:KIF6
5673:MAP4
5668:MAP2
5635:MAPs
5535:TUBB
5478:MAPs
5476:and
5417:NEFH
5412:NEFM
5407:NEFL
5366:GFAP
5014:none
4872:FLNC
4867:FLNB
4862:FLNA
4612:MYLK
4602:MYL9
4597:MYL7
4587:MYL6
4582:MYL5
4577:MYL4
4572:MYL3
4567:MYL2
4562:MYL1
4491:VII
4485:MYO6
4446:III
4410:MYH9
4405:MYH8
4395:MYH7
4390:MYH6
4385:MYH4
4380:MYH3
4375:MYH2
4370:MYH1
4252:ABPs
4250:and
4163:for
4130:PMID
4081:PMID
4063:Cell
4037:PMID
3996:PMID
3945:PMID
3896:PMID
3847:PMID
3806:PMID
3747:PMID
3697:PMID
3638:PMID
3594:PMID
3550:PMID
3515:PMID
3458:PMID
3409:PMID
3364:help
3339:PMID
3320:PMID
3279:PMID
3230:PMID
3163:PMID
3112:PMID
3063:PMID
3018:PMID
2983:PMID
2934:PMID
2883:PMID
2829:PMID
2778:PMID
2719:PMID
2678:PMID
2621:PMID
2577:PMID
2542:PMID
2493:PMID
2444:PMID
2400:PMID
2356:PMID
2289:PMID
2253:PMID
2197:PMID
2151:PMID
2116:PMID
2067:PMID
2018:PMID
1973:2015
1948:2022
1916:PMID
1791:and
1770:ANK2
1750:ANK2
1728:ANK2
1718:and
1708:ANK2
1700:ANK2
1668:ANK2
1662:1425
1653:ANK2
1619:gene
1616:ANK2
1550:and
1542:and
1515:and
1491:1425
1463:and
1432:and
1353:and
1306:and
1209:ANK2
1205:ANK2
1173:ANK2
1153:gene
1150:ANK2
159:ANK2
139:OMIM
126:ANK2
96:4RLY
92:4RLV
88:4D8O
69:RCSB
66:PDBe
35:ANK2
6263:GAN
6246:APC
5653:EB3
5648:EB2
5643:EB1
5449:A/C
5132:33B
5127:33A
4531:XV
4506:IX
4481:VI
4366:II
4161:PDB
4120:doi
4116:259
4071:doi
4067:135
4027:doi
4023:279
3986:PMC
3976:doi
3972:287
3935:PMC
3927:doi
3923:101
3886:PMC
3878:doi
3874:299
3837:doi
3796:PMC
3786:doi
3774:105
3737:PMC
3729:doi
3725:124
3687:PMC
3677:doi
3665:101
3630:doi
3586:doi
3574:421
3542:doi
3505:PMC
3497:doi
3485:304
3448:PMC
3440:doi
3399:PMC
3391:doi
3387:299
3310:doi
3269:PMC
3261:doi
3220:PMC
3210:doi
3153:doi
3139:115
3102:doi
3098:115
3055:doi
3010:doi
2973:PMC
2965:doi
2924:PMC
2914:doi
2910:286
2873:PMC
2863:doi
2859:283
2819:PMC
2809:doi
2805:285
2768:PMC
2758:doi
2746:106
2709:doi
2705:282
2668:PMC
2660:doi
2613:doi
2601:421
2569:doi
2532:PMC
2524:doi
2483:PMC
2475:doi
2471:147
2434:doi
2430:279
2390:doi
2386:279
2346:PMC
2336:doi
2324:101
2281:doi
2243:PMC
2233:doi
2187:doi
2183:277
2143:doi
2139:115
2106:PMC
2098:doi
2057:PMC
2049:doi
2008:PMC
2000:doi
1996:107
1906:PMC
1829:DMD
1722:in
1686:to
1664:Gly
1660:Glu
1546:in
1531:to
1503:in
1493:Gly
1489:Glu
1357:in
1287:in
1219:in
1163:in
1098:n/a
1083:n/a
1078:n/a
1063:n/a
826:n/a
774:n/a
731:n/a
688:n/a
670:287
163:OMA
59:PDB
6530::
5459:B2
5454:B1
5447::
5323:80
5318:79
5313:78
5308:77
5303:76
5298:75
5293:74
5288:73
5283:72
5278:71
5262:40
5257:39
5252:28
5247:27
5242:26
5237:25
5232:24
5227:23
5202:86
5197:85
5192:84
5187:83
5182:82
5177:81
5157:38
5152:37
5147:36
5142:35
5137:34
5122:32
5117:31
5074:6C
5069:6B
5064:6A
5044:2A
5019:21
5007:18
4993:20
4988:19
4983:17
4978:16
4973:15
4968:14
4963:13
4958:12
4953:10
4557:LC
4521:X
4461:V
4320:I
4303:G2
4298:G1
4293:C1
4283:A2
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