1245:. Anillin also bundles actin filaments together and drives their relative sliding. This contractile behavior is independent of myosin and ATP and may couple with actin filament disassembly. Amino acids 258-340 are sufficient and necessary for F-actin binding in Drosophila, but amino acids 246-371 are necessary to bundle actin filaments. The ability of anillin to bind to and bundle actin together is conserved through many species. It is hypothesized that by regulating actin bundling, anillin increases the efficiency of actomyosin contractility during cell division. Both anillin and F-actin are found in contractile structures. They are recruited independently to the contractile ring, but F-actin increases the efficiency of anillin targeting. Anillin may also be involved in promoting the polymerization of F-actin by stabilizing formin mDia2 in an active form.
321:
298:
195:
220:
572:
327:
226:
1204:
1292:. Depletion of RhoA halts contractile ring assembly and ingression, whereas, anillin depletion leads to a less severe phenotype when the contractile ring forms and ingresses partially. Depletion of anillin in Drosophila spermatocytes greatly reduces the localization of Rho and F-actin to equatorial regions.
1377:
Anillin is critical for cell division and therefore development and homeostasis in metazoans. In recent years, the expression levels of anillin have been shown to correlate to the metastatic potential of human tumours. In colorectal cancer, expression levels of anillin are higher in tumours and when
1164:
means ring and shows that the name anillin references the observed enrichment of anillins at the contractile ring during cytokinesis. Anillins are also enriched at other actomyosin rings, most significantly, those at the leading edge of the
Drosophila embryo during cellularization. These actomyosin
1265:
and humans leads to changes in the spatial and temporal stability of myosin during cytokinesis. In C. elegans, ANI-1 organizes myosin into foci during cytokinesis and establishment of polarity, whereas, ANI-2 is a requirement for the maintenance of myosin-rich contractile lining of oogenic gonads.
1319:
anillin interacts with Cyk-4, a central spindle protein, indicating that anillin may have a role in determining the division plane during cytokinesis. In anillin-depleted larval cells, the central spindle does not extend to the cortex. Human anillin-depleted cells show improperly positioned and
1220:
Anillins have also been shown to organize the actomyosin cytoskeleton into syncytial structures observed in
Drosophila embryos or C. elegans gonads. ANI-1 and ANI-2 (proteins homologous to anillin) are essential for embryonic viability in both organisms. ANI-1 is required for cortical ruffling,
1216:
Anillins are required for the faithfulness of cytokinesis and its F-actin-, myosin-, and septin-binding domains implicate anillin in actomyosin cytoskeletal organization. In agreement with this belief, anillin-mutant cells have disrupted contractile rings. Additionally, it is hypothesized that
1152:
showed the anillin localizes to the nucleus during interphase and to the contractile ring during cytokinesis. These observations agree with further research that found anillin in high concentrations near the cleavage furrow coinciding with RhoA, a key regulator of contractile ring formation.
1382:
cell line, the cells showed faster replication kinetics due to the lengthening of G2/M phase. Increasing the expression of anillin also led to further invasiveness and migration of numerous colorectal cancer cell lines. The hypothesis from such observations is that anillin promotes EMT and
66:
1336:
cells localize to the plus-ends of microtubules. The interaction between anillin and microtubules suggest that anillin may serve as a signaling factor to relay the position of the mitotic spindle to the cortex to ensure appropriate contractile ring formation during cytokinesis.
1349:, anillins are recruited to the equatorial cortex in a RhoA-dependent manner. This recruitment is independent of other cytoskeletal Rho targets such as myosin, F-actin, and Rho-kinase. It has been observed that anillin proteolysis is triggered after mitotic exit by the
1279:
anillin and a minimal reconstituted heterooligomer of human septins 2, 6, and 7. The ability of anillin to bind to septins is dependent on the C-terminal domain, which contains a terminal PH domain and an upstream sequence known as the βAnillin
Homologyβ (AH) domain.
1177:. The PH domain is conserved and essential for anillin functionality. The human anillin cDNA, located on Chr7, encodes a 1,125βamino acid protein with a predicted molecular mass of 124 kD and a pI of 8.1. The mouse anillin gene is located on Chromosome 9.
1221:
pseudocleavage, and all contractile events that occur in embryos prior to mitosis. ANI-1 is also crucial for segregation of polar bodies during meiosis. ANI-2 functions in the maintenance of the structure of the central core of the cytoplasm, the
1368:
ANI-2 in oogenic gonads, and Mid2p in fission yeast. These anillins that are not sequestered during interphase suggest that anillins may also regulate cytoskeletal dynamics outside the contractile ring during cytokinesis.
1257:. The interaction of anillin and myosin is also dependent on phosphorylation of the myosin light chain. The interaction of myosin and anillin does not seem to serve in recruitment, but rather organization of myosin. In
1200:(budding yeast) also have two anillin-like proteins, Boi1p and Boi2p. Boi1p and Boi2p localize to the nucleus and contractile ring at the bud neck, respectively. They are essential for cell growth and bud formation.
1304:, further supporting the idea that anillin stabilizes RhoA localization since Ect2 is an activator of RhoA. Independent of RhoA, the interaction between anillin and Ect2 occurs. This interaction is essential of the
1186:(fission yeast), there are Mid1p and Mid2p. These two anillin-like proteins do not have any overlap in their functions. Mid1p has been characterized as a key regulator in cytokinesis, responsible for arranging
1274:
Septin localization during cytokinesis and cellularization is dependent on its association with anillin. The direct interaction between anillin and septins was first shown by the interaction seen between
1253:
Anillin interacts directly with non-muscle myosin II and interacts indirectly with myosin via F-actin. Residues 142-254 (near the N-terminus) are essential for anillin binding myosin in
1854:"Fission yeast Pob1p, which is homologous to budding yeast Boi proteins and exhibits subcellular localization close to actin patches, is essential for cell elongation and separation"
1148:. It was identified as an F-actin binding protein. Six years later, the anillin gene was cloned from cDNA originating from a Drosophila ovary. Staining with anti-anillin (Antigen 8)
2797:"Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not"
2697:
Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, et al. (March 2003). "Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor".
3049:
Beausoleil SA, VillΓ©n J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".
334:
233:
2632:
Wang G, Shen W, Cui L, Chen W, Hu X, Fu J (2016). "Overexpression of
Anillin (ANLN) is correlated with colorectal cancer progression and poor prognosis".
1345:
Anillins in metazoans are heavily phosphorylated; however, the kinases responsible for the phosphorylation are unknown at the present time. In humans and
1194:
during septation, or the invagination of inner membranes, outer membranes, and the cell wall that occurs in order to separate daughter cells completely.
3016:"ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway"
1225:, during oogenesis. ANI-2 ensures oocytes do not disconnect prematurely from the rachis, thereby leading to the generation of embryos of varying sizes.
845:
826:
156:
1332:
by harnessing its interactions with both F-actin and microtubules. Furthermore, anillin-rich structures that form after
Latrunculin A treatment of
2476:"Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis"
1463:
1445:
1752:"Characterization of structural and functional domains of the anillin-related protein Mid1p that contribute to cytokinesis in fission yeast"
1173:
Anillin has a unique multi-domain structure. At the N-terminus, there is an actin- and myosin-binding domain. At the C-terminus, there is a
3139:
63:
1903:"Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site"
320:
1305:
2670:
1065:
1072:
297:
1432:
1411:
1803:"An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation"
1428:
219:
194:
2676:
1701:"Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis"
1407:
136:
2329:"Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation"
2838:
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (January 2005). "Nucleolar proteome dynamics".
333:
232:
1350:
2146:"Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity"
1182:
326:
225:
2619:
Overexpression of anillin in colorectal cancer promoter the cell proliferation, cell mobility and cell invasion
1196:
890:
144:
29:
3149:
1387:
through cytoskeletal remodeling, leading to enhanced proliferation, invasion, and mobility of tumour cells.
1144:
871:
2419:"Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring"
1261:, anillin is necessary to organize myosin into rings in the cellularization front. Depletion of anillin in
1241:
Anillin specifically binds F-actin, rather than G-actin. Binding of F-actin by anillin only occurs during
2621:. Proceedings of the 105th Annual Meeting of the American Association for Cancer Research. San Diego, CA.
1489:
2517:"Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization"
2939:
2883:
Monzo P, Gauthier NC, Keslair F, Loubat A, Field CM, Le
Marchand-Brustel Y, et al. (June 2005).
2847:
2755:
2706:
2430:
2002:
1652:
1546:
208:
123:
2682:
1048:
1019:
1015:
964:
960:
1217:
anillin couples the actomyosin cytoskeleton to microtubules by binding MgcRacGAP/CYK-4/RacGAP50C.
3117:
3074:
2871:
2730:
2456:
1678:
168:
2742:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, VillΓ©n J, Li J, et al. (August 2004).
1044:
1023:
989:
968:
571:
3109:
3066:
3037:
3002:
2967:
2914:
2863:
2826:
2783:
2722:
2649:
2599:
2548:
2497:
2448:
2399:
2350:
2309:
2268:
2219:
2167:
2126:
2077:
2028:
1968:
1924:
1883:
1834:
1783:
1732:
1670:
1618:
1564:
1512:
1379:
116:
56:
2046:
Watanabe S, Okawa K, Miki T, Sakamoto S, Morinaga T, Segawa K, et al. (September 2010).
3099:
3058:
3027:
2992:
2957:
2947:
2904:
2896:
2855:
2816:
2808:
2795:
Mollinari C, Kleman JP, Saoudi Y, Jablonski SA, Perard J, Yen TJ, et al. (March 2005).
2773:
2763:
2714:
2641:
2589:
2579:
2538:
2528:
2487:
2438:
2389:
2381:
2340:
2299:
2258:
2250:
2209:
2201:
2157:
2116:
2108:
2067:
2059:
2018:
2010:
1958:
1914:
1873:
1865:
1824:
1814:
1773:
1763:
1722:
1712:
1660:
1608:
1598:
1554:
1504:
1187:
413:
344:
288:
243:
2928:"MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis"
2979:
Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, et al. (October 2005).
2327:
Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, et al. (June 2004).
388:
164:
3086:
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006).
1228:
In vitro experiments suggest that anillin drives myosin-independent actin contractility.
2943:
2851:
2759:
2710:
2434:
2006:
1901:
D'Avino PP, Takeda T, Capalbo L, Zhang W, Lilley KS, Laue ED, et al. (April 2008).
1656:
1550:
3144:
2962:
2927:
2909:
2884:
2594:
2567:
2543:
2516:
2394:
2369:
2263:
2238:
2214:
2189:
2072:
2047:
2023:
1990:
1829:
1802:
1778:
1751:
1727:
1700:
1613:
1586:
1384:
1180:
There are also numerous anillin-like protein homologues found outside of metazoans. In
2821:
2796:
2778:
2743:
2304:
2287:
2121:
2096:
1989:
KuΔera O, Siahaan V, Janda D, Dijkstra SH, PilΓ‘tovΓ‘ E, Zatecka E, et al. (2021).
1127:
is a conserved protein implicated in cytoskeletal dynamics during cellularization and
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
623:
618:
613:
3133:
3014:
Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, et al. (December 2005).
2190:"Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila"
2048:"Rho and anillin-dependent control of mDia2 localization and function in cytokinesis"
1878:
1853:
1641:"Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis"
1587:"Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex"
1242:
1165:
rings invaginate to separate all nuclei for one another in the syncytial blastoderm.
600:
3078:
2734:
2460:
148:
127:, Scraps, scra, FSGS8, anillin actin binding protein, anillin, actin binding protein
3121:
3088:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
2875:
2417:
Gregory SL, Ebrahimi S, Milverton J, Jones WM, Bejsovec A, Saint R (January 2008).
1682:
406:
185:
3032:
3015:
2997:
2980:
1308:
activity of Ect2 and requires the AH domain of anillin and the PH domain of Ect2.
1508:
172:
1468:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1450:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1128:
3104:
3087:
2932:
Proceedings of the
National Academy of Sciences of the United States of America
2748:
Proceedings of the
National Academy of Sciences of the United States of America
2286:
Kinoshita M, Field CM, Coughlin ML, Straight AF, Mitchison TJ (December 2002).
2014:
489:
2443:
2418:
2254:
1665:
1640:
1559:
1534:
1357:
305:
202:
152:
2981:"The septin-binding protein anillin is overexpressed in diverse human tumors"
2952:
2900:
2812:
2768:
2718:
2205:
2112:
2063:
1768:
1174:
790:
549:
427:
372:
359:
271:
258:
160:
3113:
3070:
3041:
3006:
2971:
2918:
2867:
2830:
2787:
2726:
2653:
2603:
2552:
2501:
2492:
2475:
2452:
2403:
2354:
2345:
2328:
2313:
2272:
2223:
2171:
2130:
2081:
2032:
1972:
1928:
1887:
1838:
1787:
1736:
1674:
1568:
1516:
2584:
2533:
1947:"Distinct roles for two C. elegans anillins in the gonad and early embryo"
1869:
1819:
1717:
1622:
1603:
1112:
1107:
1149:
1096:
935:
916:
2859:
2188:
Goldbach P, Wong R, Beise N, Sarpal R, Trimble WS, Brill JA (May 2010).
2645:
1919:
1902:
1191:
902:
857:
22:
2239:"Some assembly required: yeast septins provide the instruction manual"
2162:
2145:
2097:"Anillin binds nonmuscle myosin II and regulates the contractile ring"
1963:
1946:
1190:
assembly and positioning. Mid2p acts later in cytokinesis to organize
93:
89:
85:
2144:
Field CM, Coughlin M, Doberstein S, Marty T, Sullivan W (June 2005).
1288:
The AH domain of human anillin is essential for its interaction with
1222:
1080:
812:
3062:
2515:
Sisson JC, Field C, Ventura R, Royou A, Sullivan W (November 2000).
2385:
2370:"The 3Ms of central spindle assembly: microtubules, motors and MAPs"
2744:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
1203:
1202:
1142:
encode Anillin. In 1989, anillin was first isolated in embryos of
775:
771:
1991:"Anillin propels myosin-independent constriction of actin rings"
1364:
anilins in the early embryo, C. elegans ANI-1 in early embryos,
1301:
1289:
1156:
The name of the protein anillin originates from a Spanish word,
1135:
580:
140:
2568:"Rho-dependent control of anillin behavior during cytokinesis"
2885:"Clues to CD2-associated protein involvement in cytokinesis"
1699:
Oegema K, Savoian MS, Mitchison TJ, Field CM (August 2000).
761:
protein localization to mitotic actomyosin contractile ring
2288:"Self- and actin-templated assembly of Mammalian septins"
396:
1945:
Maddox AS, Habermann B, Desai A, Oegema K (June 2005).
1356:
Most anillins can be sequestered to the nucleus during
1378:
anillin was over-expressed in HT29 cells, a classical
561:
2095:
Straight AF, Field CM, Mitchison TJ (January 2005).
1037:
1008:
982:
953:
1424:
1422:
1420:
1403:
1401:
1399:
343:
242:
28:"Anillin" redirects here. For similar words, see
2183:
2181:
1490:"The myriad roles of Anillin during cytokinesis"
1940:
1938:
1429:GRCm38: Ensembl release 89: ENSMUSG00000036777
1984:
1982:
1801:Tasto JJ, Morrell JL, Gould KL (March 2003).
1694:
1692:
1634:
1632:
1483:
1481:
1479:
1477:
736:hematopoietic progenitor cell differentiation
716:glomerular visceral epithelial cell migration
8:
1580:
1578:
1528:
1526:
1497:Seminars in Cell & Developmental Biology
1408:GRCh38: Ensembl release 89: ENSG00000011426
1207:The domains found in anillin across species
1852:Toya M, Iino Y, Yamamoto M (August 1999).
786:
596:
384:
283:
180:
74:
3103:
3031:
2996:
2961:
2951:
2908:
2820:
2777:
2767:
2593:
2583:
2566:Hickson GR, O'Farrell PH (January 2008).
2542:
2532:
2491:
2442:
2393:
2344:
2303:
2262:
2213:
2161:
2120:
2071:
2022:
1962:
1918:
1877:
1828:
1818:
1777:
1767:
1726:
1716:
1664:
1612:
1602:
1558:
1395:
16:Mammalian protein found in Homo sapiens
2374:Nature Reviews. Molecular Cell Biology
1488:Piekny AJ, Maddox AS (December 2010).
34:
1639:Piekny AJ, Glotzer M (January 2008).
1585:Field CM, Alberts BM (October 1995).
348:
309:
304:
247:
206:
201:
7:
2237:Versele M, Thorner J (August 2005).
1533:Zhang L, Maddox AS (February 2010).
746:actomyosin contractile ring assembly
741:positive regulation of bleb assembly
504:endothelial cell of lymphatic vessel
2480:The Journal of Biological Chemistry
2333:The Journal of Biological Chemistry
1750:Saha S, Pollard TD (October 2012).
2926:Zhao WM, Fang G (September 2005).
2474:Zhao WM, Fang G (September 2005).
1034:
1005:
979:
950:
926:
907:
881:
862:
836:
817:
751:cortical cytoskeleton organization
566:
484:
422:
401:
14:
1138:in humans and the scraps gene in
1328:Anillin was first isolated from
570:
442:inferior ganglion of vagus nerve
332:
325:
319:
296:
231:
224:
218:
193:
731:regulation of exit from mitosis
581:More reference expression data
550:More reference expression data
1:
3033:10.1158/0008-5472.CAN-05-1507
2998:10.1158/1078-0432.CCR-05-0997
2889:Molecular Biology of the Cell
2801:Molecular Biology of the Cell
2305:10.1016/S1534-5807(02)00366-0
2194:Molecular Biology of the Cell
2101:Molecular Biology of the Cell
2052:Molecular Biology of the Cell
1858:Molecular Biology of the Cell
1756:Molecular Biology of the Cell
1360:, but there are exceptions β
317:
216:
1509:10.1016/j.semcdb.2010.08.002
1320:distorted central spindles.
3140:Genes on human chromosome 7
2572:The Journal of Cell Biology
2521:The Journal of Cell Biology
1807:The Journal of Cell Biology
1705:The Journal of Cell Biology
1591:The Journal of Cell Biology
650:actomyosin contractile ring
466:superior vestibular nucleus
3166:
3105:10.1016/j.cell.2006.09.026
2681:gene details page in the
2368:Glotzer M (January 2009).
2015:10.1038/s41467-021-24474-1
1351:Anaphase Promoting Complex
27:
20:
2617:Chuang HY, Ou YH (2014).
2444:10.1016/j.cub.2007.11.050
2255:10.1016/j.tcb.2005.06.007
1666:10.1016/j.cub.2007.11.068
1560:10.1016/j.cub.2009.12.017
1464:"Mouse PubMed Reference:"
1446:"Human PubMed Reference:"
1183:Schizosaccharomyces pombe
1111:
1106:
1102:
1095:
1079:
1060:
1041:
1012:
1001:
986:
957:
946:
933:
929:
914:
910:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
796:
789:
785:
769:
599:
595:
578:
569:
560:
547:
496:
487:
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
82:
77:
60:
55:
50:
46:
42:
37:
2985:Clinical Cancer Research
1197:Saccharomyces cerevisiae
756:septin ring organization
462:internal globus pallidus
30:Aniline (disambiguation)
21:Not to be confused with
2953:10.1073/pnas.0504145102
2901:10.1091/mbc.E04-09-0773
2813:10.1091/mbc.E04-04-0346
2769:10.1073/pnas.0404720101
2719:10.1126/science.1081412
2206:10.1091/mbc.E09-08-0714
2113:10.1091/mbc.E04-08-0758
2064:10.1091/mbc.E10-04-0324
1907:Journal of Cell Science
1769:10.1091/mbc.E12-07-0536
1300:Anillin interacts with
1145:Drosophila melanogaster
1066:Chr 7: 36.39 β 36.45 Mb
2493:10.1074/jbc.M504657200
2346:10.1074/jbc.M313792200
2243:Trends in Cell Biology
1208:
1073:Chr 9: 22.24 β 22.3 Mb
500:deep cerebellar nuclei
2585:10.1083/jcb.200709005
2534:10.1083/jcb.151.4.905
1995:Nature Communications
1870:10.1091/mbc.10.8.2745
1820:10.1083/jcb.200211126
1718:10.1083/jcb.150.3.539
1604:10.1083/jcb.131.1.165
1206:
3051:Nature Biotechnology
2675:genome location and
711:septin ring assembly
311:Chromosome 9 (mouse)
209:Chromosome 7 (human)
78:List of PDB id codes
51:Available structures
2991:(19 Pt 1): 6780β6.
2944:2005PNAS..10213158Z
2860:10.1038/nature03207
2852:2005Natur.433...77A
2760:2004PNAS..10112130B
2711:2003Sci...299.1743S
2683:UCSC Genome Browser
2435:2008CBio...18...25G
2007:2021NatCo..12.4595K
1657:2008CBio...18...30P
1551:2010CBio...20.R135Z
721:mitotic cytokinesis
454:subthalamic nucleus
2646:10.3233/CBM-160585
2292:Developmental Cell
1920:10.1242/jcs.026716
1209:
891:ENSMUSG00000036777
699:Biological process
675:cell cortex region
670:actin cytoskeleton
633:Cellular component
607:Molecular function
2634:Cancer Biomarkers
2163:10.1242/dev.01843
1964:10.1242/dev.01828
1762:(20): 3993β4007.
1380:colorectal cancer
1122:
1121:
1118:
1117:
1091:
1090:
1056:
1055:
1031:
1030:
997:
996:
976:
975:
942:
941:
923:
922:
897:
896:
878:
877:
852:
851:
833:
832:
781:
780:
591:
590:
587:
586:
556:
555:
543:
542:
481:
480:
458:medulla oblongata
379:
378:
278:
277:
105:
104:
101:
100:
61:Ortholog search:
3157:
3125:
3107:
3082:
3045:
3035:
3026:(24): 11314β25.
3010:
3000:
2975:
2965:
2955:
2938:(37): 13158β63.
2922:
2912:
2879:
2834:
2824:
2791:
2781:
2771:
2738:
2705:(5613): 1743β7.
2658:
2657:
2629:
2623:
2622:
2614:
2608:
2607:
2597:
2587:
2563:
2557:
2556:
2546:
2536:
2512:
2506:
2505:
2495:
2486:(39): 33516β24.
2471:
2465:
2464:
2446:
2414:
2408:
2407:
2397:
2365:
2359:
2358:
2348:
2339:(24): 25226β33.
2324:
2318:
2317:
2307:
2283:
2277:
2276:
2266:
2234:
2228:
2227:
2217:
2185:
2176:
2175:
2165:
2141:
2135:
2134:
2124:
2092:
2086:
2085:
2075:
2058:(18): 3193β204.
2043:
2037:
2036:
2026:
1986:
1977:
1976:
1966:
1942:
1933:
1932:
1922:
1913:(Pt 8): 1151β8.
1898:
1892:
1891:
1881:
1849:
1843:
1842:
1832:
1822:
1798:
1792:
1791:
1781:
1771:
1747:
1741:
1740:
1730:
1720:
1696:
1687:
1686:
1668:
1636:
1627:
1626:
1616:
1606:
1582:
1573:
1572:
1562:
1530:
1521:
1520:
1494:
1485:
1472:
1471:
1460:
1454:
1453:
1442:
1436:
1426:
1415:
1405:
1373:Role in Diseases
1232:Binding Partners
1188:contractile ring
1104:
1103:
1075:
1068:
1051:
1035:
1026:
1006:
1002:RefSeq (protein)
992:
980:
971:
951:
927:
908:
882:
863:
837:
818:
787:
624:cadherin binding
597:
583:
574:
567:
552:
532:genital tubercle
524:efferent ductule
520:secondary oocyte
492:
490:Top expressed in
485:
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
173:ANLN - orthologs
126:
119:
96:
75:
69:
48:
47:
35:
3165:
3164:
3160:
3159:
3158:
3156:
3155:
3154:
3130:
3129:
3128:
3085:
3063:10.1038/nbt1240
3057:(10): 1285β92.
3048:
3020:Cancer Research
3013:
2978:
2925:
2895:(6): 2891β902.
2882:
2846:(7021): 77β83.
2837:
2794:
2754:(33): 12130β5.
2741:
2696:
2692:
2690:Further reading
2666:
2661:
2631:
2630:
2626:
2616:
2615:
2611:
2565:
2564:
2560:
2514:
2513:
2509:
2473:
2472:
2468:
2423:Current Biology
2416:
2415:
2411:
2386:10.1038/nrm2609
2367:
2366:
2362:
2326:
2325:
2321:
2285:
2284:
2280:
2236:
2235:
2231:
2187:
2186:
2179:
2156:(12): 2849β60.
2143:
2142:
2138:
2094:
2093:
2089:
2045:
2044:
2040:
1988:
1987:
1980:
1957:(12): 2837β48.
1944:
1943:
1936:
1900:
1899:
1895:
1851:
1850:
1846:
1813:(7): 1093β103.
1800:
1799:
1795:
1749:
1748:
1744:
1698:
1697:
1690:
1645:Current Biology
1638:
1637:
1630:
1584:
1583:
1576:
1539:Current Biology
1532:
1531:
1524:
1492:
1487:
1486:
1475:
1462:
1461:
1457:
1444:
1443:
1439:
1427:
1418:
1406:
1397:
1393:
1375:
1343:
1326:
1314:
1298:
1286:
1272:
1251:
1239:
1234:
1214:
1171:
1113:View/Edit Mouse
1108:View/Edit Human
1071:
1064:
1061:Location (UCSC)
1047:
1043:
1022:
1018:
1014:
988:
967:
963:
959:
872:ENSG00000011426
765:
694:
685:cell projection
628:
619:protein binding
579:
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
464:
460:
456:
452:
450:pars reticulata
448:
444:
440:
438:corpus callosum
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
84:
62:
33:
26:
17:
12:
11:
5:
3163:
3161:
3153:
3152:
3150:Human proteins
3147:
3142:
3132:
3131:
3127:
3126:
3083:
3046:
3011:
2976:
2923:
2880:
2835:
2807:(3): 1043β55.
2792:
2739:
2693:
2691:
2688:
2687:
2686:
2665:
2664:External links
2662:
2660:
2659:
2624:
2609:
2558:
2507:
2466:
2409:
2360:
2319:
2298:(6): 791β802.
2278:
2229:
2200:(9): 1482β93.
2177:
2136:
2107:(1): 193β201.
2087:
2038:
1978:
1934:
1893:
1864:(8): 2745β57.
1844:
1793:
1742:
1688:
1628:
1574:
1522:
1473:
1455:
1437:
1416:
1394:
1392:
1389:
1385:cell migration
1374:
1371:
1342:
1339:
1325:
1322:
1313:
1310:
1297:
1294:
1285:
1282:
1271:
1268:
1250:
1247:
1238:
1235:
1233:
1230:
1213:
1210:
1170:
1167:
1120:
1119:
1116:
1115:
1110:
1100:
1099:
1093:
1092:
1089:
1088:
1086:
1084:
1077:
1076:
1069:
1062:
1058:
1057:
1054:
1053:
1039:
1038:
1032:
1029:
1028:
1010:
1009:
1003:
999:
998:
995:
994:
984:
983:
977:
974:
973:
955:
954:
948:
944:
943:
940:
939:
931:
930:
924:
921:
920:
912:
911:
905:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
853:
850:
849:
841:
840:
834:
831:
830:
822:
821:
815:
809:
808:
803:
798:
794:
793:
783:
782:
779:
778:
767:
766:
764:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
702:
700:
696:
695:
693:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
636:
634:
630:
629:
627:
626:
621:
616:
610:
608:
604:
603:
593:
592:
589:
588:
585:
584:
576:
575:
564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
536:abdominal wall
533:
529:
525:
521:
517:
513:
509:
508:pontine nuclei
505:
501:
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
80:
79:
71:
70:
59:
53:
52:
44:
43:
40:
39:
15:
13:
10:
9:
6:
4:
3:
2:
3162:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3135:
3123:
3119:
3115:
3111:
3106:
3101:
3098:(3): 635β48.
3097:
3093:
3089:
3084:
3080:
3076:
3072:
3068:
3064:
3060:
3056:
3052:
3047:
3043:
3039:
3034:
3029:
3025:
3021:
3017:
3012:
3008:
3004:
2999:
2994:
2990:
2986:
2982:
2977:
2973:
2969:
2964:
2959:
2954:
2949:
2945:
2941:
2937:
2933:
2929:
2924:
2920:
2916:
2911:
2906:
2902:
2898:
2894:
2890:
2886:
2881:
2877:
2873:
2869:
2865:
2861:
2857:
2853:
2849:
2845:
2841:
2836:
2832:
2828:
2823:
2818:
2814:
2810:
2806:
2802:
2798:
2793:
2789:
2785:
2780:
2775:
2770:
2765:
2761:
2757:
2753:
2749:
2745:
2740:
2736:
2732:
2728:
2724:
2720:
2716:
2712:
2708:
2704:
2700:
2695:
2694:
2689:
2684:
2680:
2679:
2674:
2673:
2668:
2667:
2663:
2655:
2651:
2647:
2643:
2640:(3): 459β65.
2639:
2635:
2628:
2625:
2620:
2613:
2610:
2605:
2601:
2596:
2591:
2586:
2581:
2578:(2): 285β94.
2577:
2573:
2569:
2562:
2559:
2554:
2550:
2545:
2540:
2535:
2530:
2527:(4): 905β18.
2526:
2522:
2518:
2511:
2508:
2503:
2499:
2494:
2489:
2485:
2481:
2477:
2470:
2467:
2462:
2458:
2454:
2450:
2445:
2440:
2436:
2432:
2428:
2424:
2420:
2413:
2410:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2375:
2371:
2364:
2361:
2356:
2352:
2347:
2342:
2338:
2334:
2330:
2323:
2320:
2315:
2311:
2306:
2301:
2297:
2293:
2289:
2282:
2279:
2274:
2270:
2265:
2260:
2256:
2252:
2249:(8): 414β24.
2248:
2244:
2240:
2233:
2230:
2225:
2221:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2184:
2182:
2178:
2173:
2169:
2164:
2159:
2155:
2151:
2147:
2140:
2137:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2102:
2098:
2091:
2088:
2083:
2079:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2042:
2039:
2034:
2030:
2025:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1992:
1985:
1983:
1979:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1941:
1939:
1935:
1930:
1926:
1921:
1916:
1912:
1908:
1904:
1897:
1894:
1889:
1885:
1880:
1875:
1871:
1867:
1863:
1859:
1855:
1848:
1845:
1840:
1836:
1831:
1826:
1821:
1816:
1812:
1808:
1804:
1797:
1794:
1789:
1785:
1780:
1775:
1770:
1765:
1761:
1757:
1753:
1746:
1743:
1738:
1734:
1729:
1724:
1719:
1714:
1711:(3): 539β52.
1710:
1706:
1702:
1695:
1693:
1689:
1684:
1680:
1676:
1672:
1667:
1662:
1658:
1654:
1650:
1646:
1642:
1635:
1633:
1629:
1624:
1620:
1615:
1610:
1605:
1600:
1597:(1): 165β78.
1596:
1592:
1588:
1581:
1579:
1575:
1570:
1566:
1561:
1556:
1552:
1548:
1545:(4): R135-6.
1544:
1540:
1536:
1529:
1527:
1523:
1518:
1514:
1510:
1506:
1503:(9): 881β91.
1502:
1498:
1491:
1484:
1482:
1480:
1478:
1474:
1469:
1465:
1459:
1456:
1451:
1447:
1441:
1438:
1434:
1430:
1425:
1423:
1421:
1417:
1413:
1409:
1404:
1402:
1400:
1396:
1390:
1388:
1386:
1381:
1372:
1370:
1367:
1363:
1359:
1354:
1352:
1348:
1340:
1338:
1335:
1331:
1323:
1321:
1318:
1311:
1309:
1307:
1303:
1295:
1293:
1291:
1283:
1281:
1278:
1269:
1267:
1264:
1260:
1256:
1248:
1246:
1244:
1243:cell division
1236:
1231:
1229:
1226:
1224:
1218:
1211:
1205:
1201:
1199:
1198:
1193:
1189:
1185:
1184:
1178:
1176:
1168:
1166:
1163:
1159:
1154:
1151:
1147:
1146:
1141:
1137:
1134:
1130:
1126:
1114:
1109:
1105:
1101:
1098:
1094:
1087:
1085:
1082:
1078:
1074:
1070:
1067:
1063:
1059:
1052:
1050:
1046:
1040:
1036:
1033:
1027:
1025:
1021:
1017:
1011:
1007:
1004:
1000:
993:
991:
985:
981:
978:
972:
970:
966:
962:
956:
952:
949:
947:RefSeq (mRNA)
945:
938:
937:
932:
928:
925:
919:
918:
913:
909:
906:
904:
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
807:
804:
802:
799:
795:
792:
788:
784:
777:
773:
768:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
706:cell division
704:
703:
701:
698:
697:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
637:
635:
632:
631:
625:
622:
620:
617:
615:
614:actin binding
612:
611:
609:
606:
605:
602:
601:Gene ontology
598:
594:
582:
577:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
473:
470:Pars compacta
469:
465:
461:
457:
453:
449:
445:
441:
437:
436:
433:
429:
424:
421:
420:
417:
415:
411:
409:
408:
404:
403:
400:
398:
394:
390:
386:
382:
374:
369:
365:
361:
356:
346:
342:
335:
328:
322:
315:
307:
303:
299:
294:
290:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
24:
19:
3095:
3091:
3054:
3050:
3023:
3019:
2988:
2984:
2935:
2931:
2892:
2888:
2843:
2839:
2804:
2800:
2751:
2747:
2702:
2698:
2677:
2671:
2637:
2633:
2627:
2618:
2612:
2575:
2571:
2561:
2524:
2520:
2510:
2483:
2479:
2469:
2426:
2422:
2412:
2377:
2373:
2363:
2336:
2332:
2322:
2295:
2291:
2281:
2246:
2242:
2232:
2197:
2193:
2153:
2149:
2139:
2104:
2100:
2090:
2055:
2051:
2041:
1998:
1994:
1954:
1950:
1910:
1906:
1896:
1861:
1857:
1847:
1810:
1806:
1796:
1759:
1755:
1745:
1708:
1704:
1648:
1644:
1594:
1590:
1542:
1538:
1500:
1496:
1467:
1458:
1449:
1440:
1376:
1365:
1361:
1355:
1346:
1344:
1333:
1329:
1327:
1324:Microtubules
1316:
1315:
1299:
1287:
1276:
1273:
1262:
1258:
1254:
1252:
1240:
1227:
1219:
1215:
1195:
1181:
1179:
1172:
1161:
1157:
1155:
1143:
1139:
1132:
1124:
1123:
1049:NP_001391862
1042:
1020:NP_001271231
1016:NP_001271230
1013:
987:
965:NM_001284302
961:NM_001284301
958:
934:
915:
889:
870:
844:
825:
805:
800:
655:cytoskeleton
512:vas deferens
412:
405:
132:External IDs
83:
18:
2429:(1): 25β9.
2380:(1): 9β20.
2150:Development
2001:(1): 4595.
1951:Development
1651:(1): 30β6.
1129:cytokinesis
665:nucleoplasm
645:cell cortex
371:22,300,484
358:22,243,308
350:9|9 A3
270:36,453,791
257:36,389,821
110:Identifiers
3134:Categories
1435:, May 2017
1414:, May 2017
1391:References
1366:C. elegans
1362:Drosophila
1358:interphase
1347:Drosophila
1341:Regulation
1334:Drosophila
1330:Drosophila
1317:Drosophila
1263:Drosophila
1259:Drosophila
1140:Drosophila
726:cell cycle
446:C1 segment
416:(ortholog)
153:HomoloGene
1535:"Anillin"
1175:PH domain
1169:Structure
1045:NP_082666
1024:NP_061155
990:NM_028390
969:NM_018685
791:Orthologs
640:cytoplasm
161:GeneCards
3114:17081983
3079:14294292
3071:16964243
3042:16357138
3007:16203764
2972:16129829
2919:15800069
2868:15635413
2831:15616196
2788:15302935
2735:38625401
2727:12637748
2654:27062703
2604:18209105
2553:11076973
2502:16040610
2461:17517089
2453:18158242
2404:19197328
2355:15073184
2314:12479805
2273:16009555
2224:20237160
2172:15930114
2131:15496454
2082:20660154
2033:34321459
1973:15930113
1929:18349071
1888:10436025
1839:12668659
1788:22918954
1737:10931866
1675:18158243
1569:20178751
1517:20732437
1431:–
1410:–
1212:Function
1150:antibody
1097:Wikidata
770:Sources:
3122:7827573
2963:1201590
2940:Bibcode
2910:1142433
2876:4344740
2848:Bibcode
2756:Bibcode
2707:Bibcode
2699:Science
2595:2213597
2544:2169433
2431:Bibcode
2395:2789570
2264:1761124
2215:2861608
2073:2938385
2024:8319318
2003:Bibcode
1830:2172762
1779:3469515
1728:2175195
1683:6310134
1653:Bibcode
1623:7559773
1614:2120607
1547:Bibcode
1433:Ensembl
1412:Ensembl
1353:(APC).
1277:Xenopus
1270:Septins
1255:Xenopus
1192:septins
1125:Anillin
903:UniProt
858:Ensembl
797:Species
776:QuickGO
690:midbody
660:nucleus
391:pattern
149:1920174
117:Aliases
23:Aniline
3120:
3112:
3077:
3069:
3040:
3005:
2970:
2960:
2917:
2907:
2874:
2866:
2840:Nature
2829:
2822:551472
2819:
2786:
2779:514446
2776:
2733:
2725:
2669:Human
2652:
2602:
2592:
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2541:
2500:
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1223:rachis
1162:Anillo
1158:anillo
1131:. The
1083:search
1081:PubMed
936:Q8K298
917:Q9NQW6
813:Entrez
562:BioGPS
528:zygote
516:dermis
249:7p14.2
141:616027
3145:Genes
3118:S2CID
3075:S2CID
2872:S2CID
2731:S2CID
2457:S2CID
1879:25510
1679:S2CID
1493:(PDF)
1312:Cyk-4
1237:Actin
846:68743
827:54443
806:Mouse
801:Human
772:Amigo
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
157:41281
3110:PMID
3092:Cell
3067:PMID
3038:PMID
3003:PMID
2968:PMID
2915:PMID
2864:PMID
2827:PMID
2784:PMID
2723:PMID
2678:ANLN
2672:ANLN
2650:PMID
2600:PMID
2549:PMID
2498:PMID
2449:PMID
2400:PMID
2351:PMID
2310:PMID
2269:PMID
2220:PMID
2168:PMID
2127:PMID
2078:PMID
2029:PMID
1969:PMID
1925:PMID
1884:PMID
1835:PMID
1784:PMID
1733:PMID
1671:PMID
1619:PMID
1565:PMID
1513:PMID
1302:Ect2
1296:Ect2
1290:RhoA
1136:gene
1133:ANLN
680:bleb
474:pons
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
165:ANLN
137:OMIM
124:ANLN
94:4XOI
90:4XH3
86:2Y7B
67:RCSB
64:PDBe
38:ANLN
3100:doi
3096:127
3059:doi
3028:doi
2993:doi
2958:PMC
2948:doi
2936:102
2905:PMC
2897:doi
2856:doi
2844:433
2817:PMC
2809:doi
2774:PMC
2764:doi
2752:101
2715:doi
2703:299
2642:doi
2590:PMC
2580:doi
2576:180
2539:PMC
2529:doi
2525:151
2488:doi
2484:280
2439:doi
2390:PMC
2382:doi
2341:doi
2337:279
2300:doi
2259:PMC
2251:doi
2210:PMC
2202:doi
2158:doi
2154:132
2117:PMC
2109:doi
2068:PMC
2060:doi
2019:PMC
2011:doi
1959:doi
1955:132
1915:doi
1911:121
1874:PMC
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1825:PMC
1815:doi
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1764:doi
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