322:
299:
196:
221:
587:
580:
573:
328:
227:
29:
1971:
2025:
1188:
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in
55:
1756:"Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins"
1284:
Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3".
335:
234:
1320:
Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17".
880:
861:
157:
2094:
1895:"AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast"
2070:
1266:
2089:
1950:
1248:
1842:"Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2"
321:
128:, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
1997:
1112:
1119:
1492:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
298:
1358:
1235:
1214:
1617:"HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses"
220:
195:
1231:
2003:
52:
1210:
137:
334:
233:
2063:
327:
226:
1943:
925:
145:
1574:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
1451:"A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein"
906:
2056:
209:
1936:
1853:
1671:
1501:
2009:
1066:
1062:
1058:
1003:
999:
995:
124:
1742:
1525:
169:
1660:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1095:
1074:
1070:
1032:
1011:
1007:
1916:
1881:
1828:
1785:
1734:
1699:
1646:
1603:
1560:
1517:
1480:
1437:
1394:
1337:
1302:
586:
579:
572:
117:
45:
2040:
1906:
1871:
1861:
1818:
1810:
1775:
1767:
1724:
1689:
1679:
1636:
1628:
1593:
1585:
1550:
1509:
1470:
1462:
1427:
1419:
1386:
1329:
1294:
414:
345:
289:
244:
165:
389:
1970:
1857:
1675:
1505:
1823:
1798:
1475:
1450:
1432:
1407:
28:
1911:
1894:
1876:
1841:
1780:
1755:
1729:
1712:
1694:
1659:
1641:
1616:
1598:
1573:
1390:
1333:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
638:
633:
628:
2083:
2036:
615:
1771:
149:
1529:
407:
186:
1746:
1377:
Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis".
731:
antigen processing and presentation of exogenous peptide antigen via MHC class II
173:
1799:"Targeting signals and subunit interactions in coated vesicle adaptor complexes"
1555:
1538:
1408:"Large-scale mapping of human protein–protein interactions by mass spectrometry"
1271:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1253:
National Center for
Biotechnology Information, U.S. National Library of Medicine
490:
306:
203:
153:
1632:
1466:
825:
550:
428:
373:
360:
272:
259:
161:
1866:
1738:
1703:
1684:
1650:
1607:
1564:
1521:
1484:
1441:
1398:
1920:
1885:
1832:
1814:
1789:
1713:"Molecular architecture and functional model of the endocytic AP2 complex"
1341:
1306:
1159:
1154:
1143:
970:
951:
1513:
1589:
1423:
1359:"Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit"
1175:
937:
892:
1298:
94:
90:
86:
82:
78:
74:
1127:
847:
2024:
1539:"Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2"
1754:
Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999).
810:
806:
2032:
1182:
141:
1932:
595:
1928:
1840:
Kirchhausen T, Nathanson KL, Matsui W, et al. (1989).
1658:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
786:
low-density lipoprotein particle receptor catabolic process
397:
2044:
1893:
Kirchhausen T, Davis AC, Frucht S, et al. (1991).
1615:
Vendeville A, Rayne F, Bonhoure A, et al. (2005).
1572:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
562:
1711:Collins BM, McCoy AJ, Kent HM, et al. (2002).
1088:
1051:
1025:
988:
776:
Wnt signaling pathway, planar cell polarity pathway
501:
dentate gyrus of hippocampal formation granule cell
1227:
1225:
1223:
1206:
1204:
1202:
1537:Batonick M, Favre M, Boge M, et al. (2006).
344:
243:
1189:this gene and results in two known transcripts.
1406:Ewing RM, Chu P, Elisma F, et al. (2007).
16:Protein-coding gene in the species Homo sapiens
1449:Byland R, Vance PJ, Hoxie JA, Marsh M (2007).
1232:GRCm38: Ensembl release 89: ENSMUSG00000008036
2064:
1944:
8:
1211:GRCh38: Ensembl release 89: ENSG00000042753
2071:
2057:
1951:
1937:
1929:
821:
791:low-density lipoprotein particle clearance
665:clathrin-coated endocytic vesicle membrane
611:
385:
284:
181:
63:
1910:
1875:
1865:
1822:
1779:
1728:
1693:
1683:
1640:
1597:
1554:
1474:
1431:
1353:
1351:
705:intracellular membrane-bounded organelle
1966:
1198:
18:
349:
310:
305:
248:
207:
202:
7:
2021:
2019:
741:mitigation of host defenses by virus
2043:. You can help Knowledge (XXG) by
1085:
1048:
1022:
985:
961:
942:
916:
897:
871:
852:
567:
485:
423:
402:
14:
1178:that in humans is encoded by the
736:ephrin receptor signaling pathway
700:clathrin-coated endocytic vesicle
2023:
1969:
585:
578:
571:
333:
326:
320:
297:
232:
225:
219:
194:
27:
1772:10.1128/JVI.73.2.1350-1361.1999
761:intracellular protein transport
2095:Human chromosome 19 gene stubs
746:clathrin-dependent endocytosis
596:More reference expression data
551:More reference expression data
1:
1912:10.1016/S0021-9258(18)99141-6
1797:Page LJ, Robinson MS (1995).
1730:10.1016/S0092-8674(02)00735-3
1391:10.1016/S0959-440X(00)00071-3
1334:10.1016/S0378-1119(98)00406-5
318:
217:
2090:Genes on human chromosome 19
1846:Proc. Natl. Acad. Sci. U.S.A
1664:Proc. Natl. Acad. Sci. U.S.A
1556:10.1016/j.virol.2005.08.001
439:stromal cell of endometrium
2111:
2018:
2008:gene details page in the
1172:AP-2 complex subunit sigma
771:microtubule-based movement
766:vesicle-mediated transport
655:endocytic vesicle membrane
451:mucosa of transverse colon
1964:
1267:"Mouse PubMed Reference:"
1249:"Human PubMed Reference:"
1158:
1153:
1149:
1142:
1126:
1107:
1092:
1055:
1044:
1029:
992:
981:
968:
964:
949:
945:
936:
923:
919:
904:
900:
891:
878:
874:
859:
855:
846:
831:
824:
820:
804:
721:regulation of endocytosis
634:clathrin adaptor activity
614:
610:
593:
570:
561:
548:
497:
488:
435:
426:
396:
388:
384:
367:
354:
317:
296:
287:
283:
266:
253:
216:
193:
184:
180:
135:
132:
122:
115:
110:
71:
66:
49:
44:
39:
35:
26:
21:
1379:Curr. Opin. Struct. Biol
1113:Chr 19: 46.84 – 46.85 Mb
1633:10.1091/mbc.E03-12-0921
1467:10.1091/mbc.E06-06-0535
1120:Chr 7: 16.47 – 16.48 Mb
1867:10.1073/pnas.86.8.2612
1685:10.1073/pnas.242603899
751:clathrin coat assembly
509:superior frontal gyrus
1815:10.1083/jcb.131.3.619
781:membrane organization
680:endolysosome membrane
537:stroma of bone marrow
505:primary visual cortex
210:Chromosome 19 (human)
2002:genome location and
1287:Cytogenet Cell Genet
695:AP-2 adaptor complex
629:transporter activity
517:facial motor nucleus
459:right adrenal cortex
312:Chromosome 7 (mouse)
67:List of PDB id codes
40:Available structures
2010:UCSC Genome Browser
1858:1989PNAS...86.2612K
1676:2002PNAS...9916899M
1514:10.1038/nature04209
1506:2005Natur.437.1173R
690:clathrin-coated pit
467:left adrenal cortex
443:right adrenal gland
2031:This article on a
1590:10.1101/gr.2596504
1424:10.1038/msb4100134
926:ENSMUSG00000008036
714:Biological process
648:Cellular component
622:Molecular function
463:left adrenal gland
447:right frontal lobe
2052:
2051:
1987:
1986:
1670:(26): 16899–903.
1299:10.1159/000134463
1169:
1168:
1165:
1164:
1138:
1137:
1103:
1102:
1082:
1081:
1040:
1039:
1019:
1018:
977:
976:
958:
957:
932:
931:
913:
912:
887:
886:
868:
867:
816:
815:
756:protein transport
606:
605:
602:
601:
557:
556:
544:
543:
482:
481:
471:prefrontal cortex
380:
379:
279:
278:
174:AP2S1 - orthologs
106:
105:
102:
101:
50:Ortholog search:
2102:
2073:
2066:
2059:
2027:
2020:
1973:
1953:
1946:
1939:
1930:
1924:
1914:
1889:
1879:
1869:
1836:
1826:
1793:
1783:
1750:
1732:
1707:
1697:
1687:
1654:
1644:
1611:
1601:
1568:
1558:
1533:
1500:(7062): 1173–8.
1488:
1478:
1445:
1435:
1402:
1363:
1362:
1355:
1346:
1345:
1317:
1311:
1310:
1281:
1275:
1274:
1263:
1257:
1256:
1245:
1239:
1229:
1218:
1208:
1151:
1150:
1122:
1115:
1098:
1086:
1077:
1049:
1045:RefSeq (protein)
1035:
1023:
1014:
986:
962:
943:
917:
898:
872:
853:
822:
612:
598:
589:
582:
575:
568:
553:
525:ventricular zone
493:
491:Top expressed in
486:
431:
429:Top expressed in
424:
403:
386:
376:
363:
352:
337:
330:
324:
313:
301:
285:
275:
262:
251:
236:
229:
223:
212:
198:
182:
176:
127:
120:
97:
64:
58:
37:
36:
31:
19:
2110:
2109:
2105:
2104:
2103:
2101:
2100:
2099:
2080:
2079:
2078:
2077:
2016:
1993:
1988:
1983:
1980:
1974:
1960:
1957:
1927:
1905:(17): 11153–7.
1892:
1839:
1796:
1753:
1710:
1657:
1621:Mol. Biol. Cell
1614:
1584:(10B): 2121–7.
1571:
1536:
1491:
1455:Mol. Biol. Cell
1448:
1412:Mol. Syst. Biol
1405:
1376:
1372:
1370:Further reading
1367:
1366:
1357:
1356:
1349:
1319:
1318:
1314:
1283:
1282:
1278:
1265:
1264:
1260:
1247:
1246:
1242:
1230:
1221:
1209:
1200:
1195:
1160:View/Edit Mouse
1155:View/Edit Human
1118:
1111:
1108:Location (UCSC)
1094:
1073:
1069:
1065:
1061:
1057:
1031:
1010:
1006:
1002:
998:
994:
907:ENSG00000042753
800:
709:
675:plasma membrane
643:
639:protein binding
594:
584:
583:
577:
576:
549:
540:
535:
531:
527:
523:
519:
515:
511:
507:
503:
489:
478:
475:cingulate gyrus
473:
469:
465:
461:
457:
453:
449:
445:
441:
427:
371:
358:
350:
340:
339:
338:
331:
311:
288:Gene location (
270:
257:
249:
239:
238:
237:
230:
208:
185:Gene location (
136:
123:
116:
73:
51:
17:
12:
11:
5:
2108:
2106:
2098:
2097:
2092:
2082:
2081:
2076:
2075:
2068:
2061:
2053:
2050:
2049:
2028:
2014:
2013:
1992:
1991:External links
1989:
1985:
1984:
1982:
1981:
1975:
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1962:
1961:
1958:
1956:
1955:
1948:
1941:
1933:
1926:
1925:
1890:
1837:
1794:
1766:(2): 1350–61.
1751:
1708:
1655:
1627:(5): 2347–60.
1612:
1569:
1549:(2): 190–200.
1534:
1489:
1446:
1403:
1373:
1371:
1368:
1365:
1364:
1347:
1328:(1–2): 39–44.
1312:
1293:(2–3): 132–5.
1276:
1258:
1240:
1219:
1197:
1196:
1194:
1191:
1167:
1166:
1163:
1162:
1157:
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494:
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468:
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460:
456:
452:
448:
444:
440:
436:
433:
432:
420:
419:
411:
400:
394:
393:
390:RNA expression
382:
381:
378:
377:
369:
365:
364:
356:
353:
348:
342:
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332:
325:
319:
315:
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134:
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69:
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41:
33:
32:
24:
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15:
13:
10:
9:
6:
4:
3:
2:
2107:
2096:
2093:
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2088:
2087:
2085:
2074:
2069:
2067:
2062:
2060:
2055:
2054:
2048:
2046:
2042:
2038:
2037:chromosome 19
2034:
2029:
2026:
2022:
2017:
2011:
2007:
2006:
2001:
2000:
1995:
1994:
1990:
1978:
1972:
1967:
1963:
1954:
1949:
1947:
1942:
1940:
1935:
1934:
1931:
1922:
1918:
1913:
1908:
1904:
1900:
1899:J. Biol. Chem
1896:
1891:
1887:
1883:
1878:
1873:
1868:
1863:
1859:
1855:
1852:(8): 2612–6.
1851:
1847:
1843:
1838:
1834:
1830:
1825:
1820:
1816:
1812:
1809:(3): 619–30.
1808:
1804:
1800:
1795:
1791:
1787:
1782:
1777:
1773:
1769:
1765:
1761:
1757:
1752:
1748:
1744:
1740:
1736:
1731:
1726:
1723:(4): 523–35.
1722:
1718:
1714:
1709:
1705:
1701:
1696:
1691:
1686:
1681:
1677:
1673:
1669:
1665:
1661:
1656:
1652:
1648:
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1634:
1630:
1626:
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1613:
1609:
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1600:
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1591:
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1579:
1575:
1570:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1490:
1486:
1482:
1477:
1472:
1468:
1464:
1461:(2): 414–25.
1460:
1456:
1452:
1447:
1443:
1439:
1434:
1429:
1425:
1421:
1417:
1413:
1409:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1375:
1374:
1369:
1360:
1354:
1352:
1348:
1343:
1339:
1335:
1331:
1327:
1323:
1316:
1313:
1308:
1304:
1300:
1296:
1292:
1288:
1280:
1277:
1272:
1268:
1262:
1259:
1254:
1250:
1244:
1241:
1237:
1233:
1228:
1226:
1224:
1220:
1216:
1212:
1207:
1205:
1203:
1199:
1192:
1190:
1186:
1184:
1181:
1177:
1173:
1161:
1156:
1152:
1148:
1145:
1141:
1134:
1132:
1129:
1125:
1121:
1117:
1114:
1110:
1106:
1099:
1097:
1091:
1087:
1084:
1078:
1076:
1072:
1068:
1064:
1060:
1054:
1050:
1047:
1043:
1036:
1034:
1028:
1024:
1021:
1015:
1013:
1009:
1005:
1001:
997:
991:
987:
984:
982:RefSeq (mRNA)
980:
973:
972:
967:
963:
960:
954:
953:
948:
944:
941:
939:
935:
928:
927:
922:
918:
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908:
903:
899:
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890:
883:
882:
877:
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864:
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851:
849:
845:
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839:
837:
834:
830:
827:
823:
819:
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803:
797:
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792:
789:
787:
784:
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779:
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769:
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764:
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749:
747:
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742:
739:
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734:
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724:
722:
719:
718:
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713:
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706:
703:
701:
698:
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693:
691:
688:
686:
685:membrane coat
683:
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678:
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652:
650:
647:
646:
640:
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632:
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621:
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616:Gene ontology
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581:
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547:
536:
532:
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274:
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109:
98:
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65:
62:
61:
57:
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47:
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38:
34:
30:
25:
20:
2045:expanding it
2030:
2015:
2004:
1998:
1976:
1902:
1898:
1849:
1845:
1806:
1803:J. Cell Biol
1802:
1763:
1759:
1720:
1716:
1667:
1663:
1624:
1620:
1581:
1577:
1546:
1542:
1497:
1493:
1458:
1454:
1415:
1411:
1385:(2): 220–8.
1382:
1378:
1325:
1321:
1315:
1290:
1286:
1279:
1270:
1261:
1252:
1243:
1187:
1179:
1171:
1170:
1093:
1067:NP_001288010
1063:NP_001288007
1059:NP_001288005
1056:
1030:
1004:NM_001301081
1000:NM_001301078
996:NM_001301076
993:
969:
950:
924:
905:
879:
860:
840:
835:
413:
406:
133:External IDs
72:
1959:PDB gallery
726:endocytosis
521:neural tube
513:granulocyte
455:human penis
372:16,483,219
359:16,472,335
351:7|7 A2
271:46,850,846
258:46,838,136
111:Identifiers
2084:Categories
1578:Genome Res
1238:, May 2017
1217:, May 2017
1193:References
417:(ortholog)
154:HomoloGene
2035:on human
1418:(1): 89.
1096:NP_941015
1075:NP_067586
1071:NP_004060
1033:NM_198613
1012:NM_021575
1008:NM_004069
826:Orthologs
796:transport
162:GeneCards
1760:J. Virol
1739:12086608
1704:12477932
1651:15020715
1608:15489334
1565:16139856
1543:Virology
1522:16189514
1485:17108326
1442:17353931
1399:10753805
1234:–
1213:–
1144:Wikidata
805:Sources:
670:membrane
529:yolk sac
250:19q13.32
1921:2040623
1886:2495531
1854:Bibcode
1833:7593184
1824:2120623
1790:9882340
1672:Bibcode
1530:4427026
1502:Bibcode
1476:1783771
1433:1847948
1342:9767099
1307:9040778
1236:Ensembl
1215:Ensembl
1176:protein
938:UniProt
893:Ensembl
832:Species
811:QuickGO
660:cytosol
392:pattern
150:2141861
118:Aliases
1996:Human
1919:
1884:
1877:286967
1874:
1831:
1821:
1788:
1781:103959
1778:
1747:483953
1745:
1737:
1702:
1695:139241
1692:
1649:
1642:404028
1639:
1606:
1599:528928
1596:
1563:
1528:
1520:
1494:Nature
1483:
1473:
1440:
1430:
1397:
1340:
1305:
1130:search
1128:PubMed
971:P62743
952:P53680
881:232910
848:Entrez
563:BioGPS
142:602242
2039:is a
2005:AP2S1
1999:AP2S1
1743:S2CID
1526:S2CID
1180:AP2S1
1174:is a
841:Mouse
836:Human
807:Amigo
415:Mouse
408:Human
355:Start
290:Mouse
254:Start
187:Human
166:AP2S1
125:AP2S1
22:AP2S1
2041:stub
2033:gene
1977:1gw5
1917:PMID
1882:PMID
1829:PMID
1786:PMID
1735:PMID
1717:Cell
1700:PMID
1647:PMID
1604:PMID
1561:PMID
1518:PMID
1481:PMID
1438:PMID
1395:PMID
1338:PMID
1322:Gene
1303:PMID
1183:gene
862:1175
398:Bgee
346:Band
307:Chr.
245:Band
204:Chr.
158:3001
138:OMIM
95:4NEE
91:4UQI
87:2XA7
83:2VGL
79:2JKT
75:2JKR
56:RCSB
53:PDBe
1907:doi
1903:266
1872:PMC
1862:doi
1819:PMC
1811:doi
1807:131
1776:PMC
1768:doi
1725:doi
1721:109
1690:PMC
1680:doi
1637:PMC
1629:doi
1594:PMC
1586:doi
1551:doi
1547:342
1510:doi
1498:437
1471:PMC
1463:doi
1428:PMC
1420:doi
1387:doi
1330:doi
1326:220
1295:doi
533:lip
368:End
267:End
170:OMA
146:MGI
46:PDB
2086::
1979::
1915:.
1901:.
1897:.
1880:.
1870:.
1860:.
1850:86
1848:.
1844:.
1827:.
1817:.
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1580:.
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1559:.
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1541:.
1524:.
1516:.
1508:.
1496:.
1479:.
1469:.
1459:18
1457:.
1453:.
1436:.
1426:.
1414:.
1410:.
1393:.
1383:10
1381:.
1350:^
1336:.
1324:.
1301:.
1291:75
1289:.
1269:.
1251:.
1222:^
1201:^
1185:.
809:/
374:bp
361:bp
273:bp
260:bp
168:;
164::
160:;
156::
152:;
148::
144:;
140::
93:,
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77:,
2072:e
2065:t
2058:v
2047:.
2012:.
1952:e
1945:t
1938:v
1923:.
1909::
1888:.
1864::
1856::
1835:.
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1770::
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1682::
1674::
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1273:.
1255:.
292:)
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172::
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