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369:, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin. APH-1 contains a conserved
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Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G (February 2004).
655:
406:"APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos"
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388:) that is essential to both assembly of the gamma secretase complex and to the maturation of the components.
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556:"A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex"
317:. APH-1 homologs in other organisms, including humans, have since been identified as components of the
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349:(APP). Gamma-secretase cleavage of APP is one of two proteolytic steps required to generate the
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Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H (March 2003).
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Proceedings of the
National Academy of Sciences of the United States of America
515:"PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1"
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365:. All of the components of the gamma-secretase complex undergo extensive
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Goutte C, Tsunozaki M, Hale VA, Priess JR (January 2002).
636:
465:"Assembly, trafficking and function of gamma-secretase"
313:as a regulator of the cell-surface localization of
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anterior pharynx defective 1 homolog B (C. elegans)
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anterior pharynx defective 1 homolog A (C. elegans)
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333:. The gamma-secretase complex is a multimeric
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600:at the U.S. National Library of Medicine
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321:complex along with the catalytic subunit
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361:form is implicated in the causation of
463:Kaether C, Haass C, Steiner H (2006).
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296:(anterior pharynx-defective 1) is a
560:The Journal of Biological Chemistry
519:The Journal of Biological Chemistry
635:. You can help Knowledge (XXG) by
337:responsible for the intramembrane
14:
615:
367:post-translational modification
702:Human chromosome 15 gene stubs
345:such as the Notch protein and
1:
303:originally identified in the
687:Genes on human chromosome 15
325:and the regulatory subunits
682:Genes on human chromosome 1
472:Neuro-Degenerative Diseases
718:
610:
347:amyloid precursor protein
258:
121:
602:Medical Subject Headings
305:Notch signaling pathway
573:10.1074/jbc.M309745200
532:10.1074/jbc.C200648200
431:10.1073/pnas.022523499
343:transmembrane proteins
310:Caenorhabditis elegans
598:APH-1+protein,+human
16:Protein gene product
692:Alzheimer's disease
422:2002PNAS...99..775G
363:Alzheimer's disease
623:This article on a
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484:10.1159/000095267
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319:gamma secretase
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629:chromosome 15
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637:expanding it
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416:(2): 775–9.
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373:interaction
355:amyloid beta
308:
301:gene product
293:
292:
250:
115:p36.13-q31.3
113:
371:alpha helix
339:proteolysis
272:Swiss-model
164:Identifiers
135:Swiss-model
27:Identifiers
676:Categories
392:References
323:presenilin
268:Structures
263:Search for
237:Other data
131:Structures
126:Search for
100:Other data
627:on human
359:misfolded
353:known as
327:nicastrin
315:nicastrin
219:NM_031301
178:NCBI gene
82:NM_016022
41:NCBI gene
697:Proteins
582:14627705
541:12522139
500:17324271
492:17047368
450:11792846
357:, whose
335:protease
282:InterPro
145:InterPro
418:Bibcode
382:glycine
380:-X-X-X-
378:glycine
351:peptide
298:protein
278:Domains
248:Chr. 15
226:UniProt
141:Domains
89:UniProt
604:(MeSH)
580:
539:
498:
490:
448:
441:117381
438:
231:Q8WW43
214:RefSeq
207:607630
169:Symbol
111:Chr. 1
94:Q96BI3
77:RefSeq
70:607629
32:Symbol
631:is a
496:S2CID
468:(PDF)
386:GXXXG
375:motif
331:PEN-2
294:APH-1
252:q22.2
243:Locus
195:24080
183:83464
172:APH1B
106:Locus
58:29509
46:51107
35:APH1A
633:stub
625:gene
578:PMID
537:PMID
488:PMID
446:PMID
329:and
202:OMIM
190:HGNC
65:OMIM
53:HGNC
568:doi
564:279
527:doi
523:278
480:doi
436:PMC
426:doi
341:of
307:in
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664:e
657:t
650:v
639:.
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476:3
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428::
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384:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.