313:
290:
187:
212:
564:
319:
218:
1909:
1320:
Yamazaki, Hiroyuki; Shirakawa, Kotaro; Matsumoto, Tadahiko; Hirabayashi, Shigeki; Murakawa, Yasuhiro; Kobayashi, Masayuki; Sarca, Anamaria
Daniela; Kazuma, Yasuhiro; Matsui, Hiroyuki; Maruyama, Wataru; Fukuda, Hirofumi; Shirakawa, Ryutaro; Shindo, Keisuke; Ri, Masaki; Iida, Shinsuke; Takaori-Kondo,
1127:
control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can cause specific mutations in cancer genomes called APOBEC mutagenesis and several factors including genetic and environmental influence this
50:
1889:
Steven A Roberts, Michael S Lawrence, Leszek J Klimczak, Sara A Grimm, David Fargo, Petar
Stojanov, Adam Kiezun, Gregory V Kryukov, Scott L Carter, Gordon Saksena, Shawn Harris, Ruchir R Shah, Michael A Resnick, Gad Getz & Dmitry A Gordenin
1894:
Candace D Middlebrooks, A Rouf Banday, Konichi
Matsuda, et al. Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors Exit Disclaimer. Nature Genetics
1227:
Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22".
326:
225:
1262:
Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE (Sep 1999).
1411:
Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business".
148:
792:
773:
1978:
1954:
1697:
Rose KM, Marin M, Kozak SL, Kabat D (2005). "Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G".
1973:
1209:
1191:
1384:
312:
1016:
1115:. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase
1023:
289:
1306:
1178:
1157:
1390:
211:
186:
1174:
47:
1441:
1153:
1264:"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1"
325:
224:
128:
119:, A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
318:
217:
1947:
837:
136:
1323:"Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells"
1128:
mutation pattern among patients specifically in bladder and breast cancer. This gene is also overexpressed in
1656:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
818:
1940:
200:
1499:
1456:
1334:
115:
1396:
995:
991:
966:
940:
932:
911:
563:
1093:
160:
1771:"APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism"
1488:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
999:
970:
936:
907:
1872:
1827:
1792:
1757:
1714:
1685:
1642:
1607:
1562:
1527:
1474:
1428:
1362:
1285:
1244:
156:
108:
40:
1924:
1862:
1852:
1817:
1782:
1747:
1739:
1728:"APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells"
1706:
1675:
1667:
1632:
1597:
1587:
1552:
1517:
1507:
1464:
1420:
1352:
1342:
1275:
1236:
1129:
1108:
405:
336:
280:
235:
1307:"Entrez Gene: APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B"
1621:"APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication"
1104:
380:
606:
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
1806:"Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains"
1503:
1460:
1338:
1867:
1840:
1752:
1727:
1357:
1322:
1680:
1655:
1602:
1575:
1557:
1540:
1522:
1487:
1424:
707:
702:
697:
692:
687:
682:
677:
661:
656:
640:
635:
630:
625:
620:
610:
605:
1967:
1920:
1280:
1263:
1112:
592:
140:
398:
177:
1857:
1592:
1576:"Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G"
164:
1214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1096:
1885:
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
1347:
481:
1124:
1100:
297:
194:
144:
1710:
737:
541:
419:
364:
351:
263:
250:
152:
1876:
1831:
1822:
1805:
1796:
1787:
1770:
1761:
1718:
1689:
1646:
1637:
1620:
1611:
1566:
1531:
1512:
1478:
1432:
1366:
1289:
1248:
1240:
1063:
1058:
1841:"Population Stratification of a Common APOBEC Gene Deletion Polymorphism"
1743:
1047:
882:
863:
615:
1671:
1116:
1079:
849:
804:
85:
81:
77:
73:
69:
1120:
1031:
759:
1908:
1469:
1541:"Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif"
722:
718:
1916:
1086:
132:
572:
1486:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1539:
Mariani R, Chen D, Schröfelbauer B, et al. (2003).
388:
1928:
1654:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1726:
Bogerd HP, Wiegand HL, Doehle BP, et al. (2006).
1119:. It is thought that the proteins may be RNA editing
553:
984:
959:
925:
900:
1170:
1168:
1166:
1149:
1147:
1145:
1839:Kidd JM, Newman TL, Tuzun E, et al. (2007).
1440:Dunham I, Shimizu N, Roe BA, et al. (1999).
335:
234:
1076:Probable DNA dC->dU-editing enzyme APOBEC-3B
16:Protein-coding gene in the species Homo sapiens
1175:GRCm38: Ensembl release 89: ENSMUSG00000009585
1948:
8:
1619:Yu Q, Chen D, König R, et al. (2005).
1154:GRCh38: Ensembl release 89: ENSG00000179750
1955:
1941:
733:
588:
376:
275:
172:
58:
1866:
1856:
1821:
1786:
1751:
1679:
1636:
1601:
1591:
1556:
1521:
1511:
1468:
1442:"The DNA sequence of human chromosome 22"
1356:
1346:
1279:
1301:
1299:
1574:Sawyer SL, Emerman M, Malik HS (2006).
1141:
1099:. It is one of seven related genes or
18:
340:
301:
296:
239:
198:
193:
7:
1905:
1903:
678:negative regulation of transposition
1927:. You can help Knowledge (XXG) by
981:
956:
922:
897:
873:
854:
828:
809:
783:
764:
558:
476:
414:
393:
14:
1132:, possibly aiding its formation.
1082:that in humans is encoded by the
1907:
1769:Stenglein MD, Harris RS (2006).
1281:10.1046/j.1523-1747.1999.00682.x
631:deoxycytidine deaminase activity
562:
324:
317:
311:
288:
223:
216:
210:
185:
1979:Human chromosome 22 gene stubs
573:More reference expression data
542:More reference expression data
1:
1558:10.1016/S0092-8674(03)00515-4
1425:10.1016/S0168-9525(03)00054-4
1092:This gene is a member of the
309:
208:
1974:Genes on human chromosome 22
1858:10.1371/journal.pgen.0030063
1804:Hakata Y, Landau NR (2007).
1593:10.1371/journal.pbio.0020275
1492:Proc. Natl. Acad. Sci. U.S.A
1123:and have roles in growth or
1699:AIDS Res. Hum. Retroviruses
703:cytidine to uridine editing
641:cytidine deaminase activity
520:subcutaneous adipose tissue
458:stromal cell of endometrium
1995:
1902:
1395:gene details page in the
1348:10.1038/s41598-019-43575-y
434:mucosa of transverse colon
1210:"Mouse PubMed Reference:"
1192:"Human PubMed Reference:"
1107:, thought to result from
1062:
1057:
1053:
1046:
1030:
1011:
988:
963:
952:
929:
904:
893:
880:
876:
861:
857:
848:
835:
831:
816:
812:
803:
790:
786:
771:
767:
758:
743:
736:
732:
716:
693:defense response to virus
591:
587:
570:
561:
552:
539:
488:
479:
426:
417:
387:
379:
375:
358:
345:
308:
287:
278:
274:
257:
244:
207:
184:
175:
171:
126:
123:
113:
106:
101:
66:
61:
44:
39:
34:
30:
26:
21:
1017:Chr 22: 38.98 – 38.99 Mb
1711:10.1089/aid.2005.21.611
1024:Chr 15: 79.78 – 79.8 Mb
1823:10.1074/jbc.M604980200
1788:10.1074/jbc.M602367200
1638:10.1074/jbc.M408802200
1513:10.1073/pnas.242603899
1321:Akifumi (9 May 2019).
1241:10.1006/geno.2002.6718
683:innate immune response
492:mesenteric lymph nodes
342:15 E1|15 37.85 cM
688:immune system process
524:epithelium of urethra
303:Chromosome 15 (mouse)
201:Chromosome 22 (human)
1389:genome location and
698:cytidine deamination
165:APOBEC3B - orthologs
62:List of PDB id codes
35:Available structures
1504:2002PNAS...9916899M
1461:1999Natur.402..489D
1397:UCSC Genome Browser
1339:2019NatSR...9.7122Y
454:islet of Langerhans
1915:This article on a
1744:10.1093/nar/gkj416
1672:10.1101/gr.2596504
1327:Scientific Reports
1094:cytidine deaminase
838:ENSMUSG00000009585
671:Biological process
650:Cellular component
621:hydrolase activity
616:catalytic activity
599:Molecular function
1936:
1935:
1732:Nucleic Acids Res
1498:(26): 16899–903.
1268:J Invest Dermatol
1073:
1072:
1069:
1068:
1042:
1041:
1007:
1006:
978:
977:
948:
947:
919:
918:
889:
888:
870:
869:
844:
843:
825:
824:
799:
798:
780:
779:
728:
727:
708:DNA demethylation
626:metal ion binding
583:
582:
579:
578:
548:
547:
535:
534:
473:
472:
450:bone marrow cells
371:
370:
270:
269:
97:
96:
93:
92:
45:Ortholog search:
1986:
1957:
1950:
1943:
1911:
1904:
1880:
1870:
1860:
1835:
1825:
1816:(48): 36624–31.
1800:
1790:
1781:(25): 16837–41.
1765:
1755:
1722:
1693:
1683:
1650:
1640:
1631:(51): 53379–86.
1615:
1605:
1595:
1570:
1560:
1535:
1525:
1515:
1482:
1472:
1455:(6761): 489–95.
1446:
1436:
1371:
1370:
1360:
1350:
1317:
1311:
1310:
1303:
1294:
1293:
1283:
1259:
1253:
1252:
1224:
1218:
1217:
1206:
1200:
1199:
1188:
1182:
1172:
1161:
1151:
1130:multiple myeloma
1109:gene duplication
1055:
1054:
1026:
1019:
1002:
982:
973:
957:
953:RefSeq (protein)
943:
923:
914:
898:
874:
855:
829:
810:
784:
765:
734:
611:zinc ion binding
589:
575:
566:
559:
544:
484:
482:Top expressed in
477:
422:
420:Top expressed in
415:
394:
377:
367:
354:
343:
328:
321:
315:
304:
292:
276:
266:
253:
242:
227:
220:
214:
203:
189:
173:
167:
118:
111:
88:
59:
53:
32:
31:
19:
1994:
1993:
1989:
1988:
1987:
1985:
1984:
1983:
1964:
1963:
1962:
1961:
1900:
1898:
1838:
1803:
1768:
1725:
1696:
1666:(10B): 2121–7.
1653:
1618:
1573:
1538:
1485:
1444:
1439:
1410:
1406:
1404:Further reading
1380:
1375:
1374:
1319:
1318:
1314:
1305:
1304:
1297:
1261:
1260:
1256:
1226:
1225:
1221:
1208:
1207:
1203:
1190:
1189:
1185:
1173:
1164:
1152:
1143:
1138:
1064:View/Edit Mouse
1059:View/Edit Human
1022:
1015:
1012:Location (UCSC)
998:
994:
990:
969:
965:
939:
935:
931:
910:
906:
819:ENSG00000179750
712:
666:
645:
571:
540:
531:
528:ascending aorta
526:
522:
518:
514:
510:
506:
502:
498:
494:
480:
469:
464:
460:
456:
452:
448:
444:
440:
436:
432:
418:
362:
349:
341:
331:
330:
329:
322:
302:
279:Gene location (
261:
248:
240:
230:
229:
228:
221:
199:
176:Gene location (
127:
114:
107:
68:
46:
17:
12:
11:
5:
1992:
1990:
1982:
1981:
1976:
1966:
1965:
1960:
1959:
1952:
1945:
1937:
1934:
1933:
1912:
1897:
1896:
1887:
1886:
1882:
1881:
1836:
1801:
1766:
1723:
1694:
1651:
1616:
1571:
1536:
1483:
1470:10.1038/990031
1437:
1407:
1405:
1402:
1401:
1400:
1379:
1378:External links
1376:
1373:
1372:
1312:
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1254:
1219:
1201:
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1137:
1134:
1071:
1070:
1067:
1066:
1061:
1051:
1050:
1044:
1043:
1040:
1039:
1037:
1035:
1028:
1027:
1020:
1013:
1009:
1008:
1005:
1004:
986:
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979:
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961:
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949:
946:
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926:
920:
917:
916:
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901:
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890:
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871:
868:
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826:
823:
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797:
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769:
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741:
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714:
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497:
493:
489:
486:
485:
474:
471:
470:
468:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
424:
423:
411:
410:
402:
391:
385:
384:
381:RNA expression
373:
372:
369:
368:
360:
356:
355:
347:
344:
339:
333:
332:
323:
316:
310:
306:
305:
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285:
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272:
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222:
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209:
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197:
191:
190:
182:
181:
169:
168:
125:
121:
120:
112:
104:
103:
99:
98:
95:
94:
91:
90:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1991:
1980:
1977:
1975:
1972:
1971:
1969:
1958:
1953:
1951:
1946:
1944:
1939:
1938:
1932:
1930:
1926:
1922:
1921:chromosome 22
1918:
1913:
1910:
1906:
1901:
1893:
1892:
1891:
1884:
1883:
1878:
1874:
1869:
1864:
1859:
1854:
1850:
1846:
1842:
1837:
1833:
1829:
1824:
1819:
1815:
1811:
1810:J. Biol. Chem
1807:
1802:
1798:
1794:
1789:
1784:
1780:
1776:
1775:J. Biol. Chem
1772:
1767:
1763:
1759:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1695:
1691:
1687:
1682:
1677:
1673:
1669:
1665:
1661:
1657:
1652:
1648:
1644:
1639:
1634:
1630:
1626:
1625:J. Biol. Chem
1622:
1617:
1613:
1609:
1604:
1599:
1594:
1589:
1585:
1581:
1577:
1572:
1568:
1564:
1559:
1554:
1550:
1546:
1542:
1537:
1533:
1529:
1524:
1519:
1514:
1509:
1505:
1501:
1497:
1493:
1489:
1484:
1480:
1476:
1471:
1466:
1462:
1458:
1454:
1450:
1443:
1438:
1434:
1430:
1426:
1422:
1419:(4): 207–16.
1418:
1414:
1409:
1408:
1403:
1398:
1394:
1393:
1388:
1387:
1382:
1381:
1377:
1368:
1364:
1359:
1354:
1349:
1344:
1340:
1336:
1332:
1328:
1324:
1316:
1313:
1308:
1302:
1300:
1296:
1291:
1287:
1282:
1277:
1273:
1269:
1265:
1258:
1255:
1250:
1246:
1242:
1238:
1235:(3): 285–96.
1234:
1230:
1223:
1220:
1215:
1211:
1205:
1202:
1197:
1193:
1187:
1184:
1180:
1176:
1171:
1169:
1167:
1163:
1159:
1155:
1150:
1148:
1146:
1142:
1135:
1133:
1131:
1126:
1122:
1118:
1114:
1113:chromosome 22
1110:
1106:
1102:
1098:
1095:
1090:
1088:
1085:
1081:
1077:
1065:
1060:
1056:
1052:
1049:
1045:
1038:
1036:
1033:
1029:
1025:
1021:
1018:
1014:
1010:
1003:
1001:
997:
993:
987:
983:
980:
974:
972:
968:
962:
958:
955:
951:
944:
942:
938:
934:
928:
924:
921:
915:
913:
909:
903:
899:
896:
894:RefSeq (mRNA)
892:
885:
884:
879:
875:
872:
866:
865:
860:
856:
853:
851:
847:
840:
839:
834:
830:
827:
821:
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593:Gene ontology
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1929:expanding it
1914:
1899:
1888:
1848:
1844:
1813:
1809:
1778:
1774:
1738:(1): 89–95.
1735:
1731:
1705:(7): 611–9.
1702:
1698:
1663:
1659:
1628:
1624:
1583:
1579:
1551:(1): 21–31.
1548:
1544:
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1413:Trends Genet
1412:
1391:
1385:
1330:
1326:
1315:
1274:(2): 162–9.
1271:
1267:
1257:
1232:
1228:
1222:
1213:
1204:
1195:
1186:
1091:
1083:
1075:
1074:
996:NP_001333970
992:NP_001153887
989:
967:NP_001257340
964:
941:NM_001347041
933:NM_001160415
930:
912:NM_001270411
905:
881:
862:
836:
817:
791:
772:
752:
747:
512:aortic valve
404:
397:
124:External IDs
67:
1586:(9): E275.
1333:(1): 7122.
1103:found in a
1101:pseudogenes
1097:gene family
636:RNA binding
504:bone marrow
500:granulocyte
438:bone marrow
363:79,800,107
350:79,775,860
262:38,992,804
249:38,982,347
102:Identifiers
1968:Categories
1851:(4): e63.
1845:PLOS Genet
1660:Genome Res
1181:, May 2017
1160:, May 2017
1136:References
1125:cell cycle
408:(ortholog)
145:HomoloGene
1919:on human
1580:PLOS Biol
1000:NP_084531
971:NP_004891
937:NM_030255
908:NM_004900
738:Orthologs
662:cytoplasm
153:GeneCards
1877:17447845
1832:17020885
1797:16648136
1762:16407327
1719:16060832
1690:15489334
1647:15466872
1612:15269786
1567:12859895
1532:12477932
1479:10591208
1433:12683974
1392:APOBEC3B
1386:APOBEC3B
1367:31073151
1290:10469298
1249:11863358
1229:Genomics
1177:–
1156:–
1084:APOBEC3B
1048:Wikidata
717:Sources:
466:appendix
462:duodenum
157:APOBEC3B
116:APOBEC3B
22:APOBEC3B
1868:1853121
1753:1326241
1500:Bibcode
1457:Bibcode
1358:6509214
1335:Bibcode
1179:Ensembl
1158:Ensembl
1121:enzymes
1117:APOBEC1
1105:cluster
1080:protein
850:UniProt
805:Ensembl
744:Species
723:QuickGO
657:nucleus
383:pattern
241:22q13.1
141:1933111
109:Aliases
1875:
1865:
1830:
1795:
1760:
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1717:
1688:
1681:528928
1678:
1645:
1610:
1603:479043
1600:
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1523:139241
1520:
1477:
1449:Nature
1431:
1383:Human
1365:
1355:
1288:
1247:
1034:search
1032:PubMed
883:Q99J72
864:Q9UH17
760:Entrez
554:BioGPS
516:spleen
508:embryo
496:thymus
442:rectum
149:105420
133:607110
1923:is a
1895:2016.
1445:(PDF)
1111:, on
1078:is a
793:80287
753:Mouse
748:Human
719:Amigo
446:blood
430:gonad
406:Mouse
399:Human
346:Start
281:Mouse
245:Start
178:Human
1925:stub
1917:gene
1873:PMID
1828:PMID
1793:PMID
1758:PMID
1715:PMID
1686:PMID
1643:PMID
1608:PMID
1563:PMID
1545:Cell
1528:PMID
1475:PMID
1429:PMID
1363:PMID
1286:PMID
1245:PMID
1087:gene
774:9582
389:Bgee
337:Band
298:Chr.
236:Band
195:Chr.
129:OMIM
86:2NBQ
82:5CQK
78:5CQI
74:5CQH
70:5CQD
51:RCSB
48:PDBe
1863:PMC
1853:doi
1818:doi
1814:281
1783:doi
1779:281
1748:PMC
1740:doi
1707:doi
1676:PMC
1668:doi
1633:doi
1629:279
1598:PMC
1588:doi
1553:doi
1549:114
1518:PMC
1508:doi
1465:doi
1453:402
1421:doi
1353:PMC
1343:doi
1276:doi
1272:113
1237:doi
359:End
258:End
161:OMA
137:MGI
41:PDB
1970::
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1298:^
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1231:.
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1165:^
1144:^
1089:.
721:/
365:bp
352:bp
264:bp
251:bp
159:;
155::
151:;
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131::
84:,
80:,
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72:,
1956:e
1949:t
1942:v
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283:)
180:)
163::
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