1486:. Ku80(-/-) mice exhibit aging-related pathology (osteopenia, atrophic skin, hepatocellular degeneration, hepatocellular inclusions, hepatic hyperplastic foci and age-specific mortality). Furthermore, Ku80(-/-) mice exhibit severely reduced lifespan and size. Loss of only a single Ku80 allele in Ku(-/+) heterozygous mice causes accelerated aging in skeletal muscle, although post natal growth is normal. An analysis of the level of Ku80 protein in human, cow, and mouse indicated that Ku80 levels vary dramatically between species, and that these levels are strongly correlated with
331:
308:
205:
230:
589:
582:
3702:
3687:
337:
236:
42:
3717:
3672:
68:
3470:
Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP (1996). "A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion".
3031:"Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter"
2739:
Adam L, Bandyopadhyay D, Kumar R (January 2000). "Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2".
3345:
Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA (1994). "Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination".
3109:"Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome"
2191:
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication".
2528:"A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein"
1490:. These results suggest that the NHEJ pathway of DNA repair mediated by Ku80 plays a significant role in repairing double-strand breaks that would otherwise cause early senescence (see
1525:). Ku80 protein expression was found to be deficient in melanoma. In addition, low expression of Ku80 was found in 15% of adenocarcinoma type and 32% of squamous cell type
2912:
Chen DJ, Park MS, Campbell E, Oshimura M, Liu P, Zhao Y, White BF, Siciliano MJ (1992). "Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2".
344:
243:
3383:
Chen DJ, Marrone BL, Nguyen T, Stackhouse M, Zhao Y, Siciliano MJ (1994). "Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping".
3197:"Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen"
2232:"Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex"
137:, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
3537:"KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity"
2487:"Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase"
1077:
166:
1058:
3701:
1714:"Entrez Gene: XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)"
1895:
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P (2014).
1611:
3686:
3651:
1692:
1674:
3745:
3412:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1729:"Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing"
1293:
330:
1300:
307:
1776:
1713:
1599:
3716:
3671:
3623:
provides an overview of all the structure information available in the PDB for Human X-ray repair cross-complementing protein 5
3502:"Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element"
1661:
1640:
1657:
229:
204:
65:
2569:"Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells"
1797:"Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer"
1526:
1459:
1636:
1409:
146:
3316:
Cao QP, Pitt S, Leszyk J, Baril EF (1994). "DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen".
1549:
1536:
Ku80 appears to be one of 26 different DNA repair proteins that are epigenetically repressed in various cancers (see
343:
242:
2777:"Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus"
2005:"Significant correlation of species longevity with DNA double strand break recognition but not with telomere length"
1777:"Entrez Gene: XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)"
1491:
1383:
2618:"The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase"
336:
235:
3644:
2428:"Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator"
1503:
1122:
154:
2941:
Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A (1992).
2943:"Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells"
3283:"The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity"
3238:
Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J (1994).
1103:
2978:"Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2"
2003:
Lorenzini A, Johnson FB, Oliver A, Tresini M, Smith JS, Hdeib M, Sell C, Cristofalo VJ, Stamato TD (2009).
1956:"Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle"
1506:
1463:
3580:"Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit"
2147:"Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit"
2054:"Differential expression of DNA nonhomologous end-joining proteins Ku70 and Ku80 in melanoma progression"
3066:"The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes"
1466:
at the XRCC5 locus and a similar percentage of tumors had hypermethylation of the promoter region of
17:
3637:
3355:
3120:
2989:
2882:
2439:
2279:
Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA (May 1999).
1908:
1849:
218:
133:
2616:
Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (May 2001).
1391:
1276:
1272:
1221:
1217:
2408:
1537:
1470:. Low protein expression of Ku80 was significantly associated with low mRNA expression and with
178:
1268:
1247:
1213:
1192:
3601:
3566:
3523:
3488:
3458:
3429:
3400:
3371:
3333:
3304:
3269:
3226:
3183:
3148:
3095:
3052:
3017:
2976:
Jeggo PA, Hafezparast M, Thompson AF, Broughton BC, Kaur GP, Zdzienicka MZ, Athwal RS (1992).
2964:
2929:
2900:
2847:
2806:
2757:
2721:
2680:
2639:
2598:
2549:
2508:
2467:
2400:
2359:
2310:
2261:
2209:
2168:
2127:
2075:
2034:
1985:
1936:
1877:
1818:
1758:
1605:
1487:
588:
581:
126:
58:
3591:
3556:
3548:
3513:
3480:
3450:
3421:
3392:
3363:
3325:
3294:
3259:
3251:
3216:
3208:
3173:
3138:
3128:
3085:
3077:
3042:
3007:
2997:
2954:
2921:
2890:
2837:
2796:
2788:
2749:
2711:
2670:
2629:
2588:
2580:
2539:
2498:
2457:
2447:
2390:
2349:
2341:
2300:
2292:
2251:
2243:
2230:
Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL (March 1998).
2201:
2158:
2117:
2109:
2065:
2024:
2016:
1975:
1967:
1926:
1916:
1867:
1857:
1808:
1748:
1740:
1510:
423:
354:
298:
253:
3441:
Kaczmarski W, Khan SA (1993). "Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro".
174:
1451:
398:
3281:
Le
Romancer M, Reyl-Desmars F, Cherifi Y, Pigeon C, Bottari S, Meyer O, Lewin MJ (1994).
2826:"Functional interaction between Ku and the werner syndrome protein in DNA end processing"
2098:"Mapping of protein-protein interactions within the DNA-dependent protein kinase complex"
3359:
3124:
3107:
Mimori T, Ohosone Y, Hama N, Suwa A, Akizuki M, Homma M, Griffith AJ, Hardin JA (1990).
2993:
2886:
2443:
1912:
1853:
3561:
3536:
3255:
3212:
3090:
3065:
2029:
2004:
1980:
1955:
1931:
1896:
1753:
1728:
1522:
1413:
41:
3299:
3282:
3264:
3240:"Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen"
3239:
3221:
3196:
3178:
3161:
3047:
3030:
2959:
2942:
2801:
2776:
2395:
2378:
2305:
2280:
2256:
2231:
2205:
2122:
2097:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
3739:
3620:
3425:
3143:
3108:
3012:
2977:
2925:
2593:
2568:
2462:
2427:
2354:
2330:"The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit"
2329:
1872:
1837:
1395:
617:
2700:"Human Ku70/80 associates physically with telomerase through interaction with hTERT"
2412:
2328:
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA (May 1999).
1521:
A deficiency in expression of a DNA repair gene increases the risk for cancer (see
1371:
416:
195:
158:
2052:
Korabiowska M, Tscherny M, Stachura J, Berger H, Cordon-Cardo C, Brinck U (2002).
1813:
1796:
1921:
1897:"The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency"
182:
1697:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1679:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1447:
1394:, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian
3552:
499:
2070:
2053:
2020:
1744:
1483:
1387:
315:
212:
162:
3596:
3579:
3518:
3501:
2296:
2163:
2146:
2113:
1862:
3367:
3002:
2584:
2452:
1022:
559:
437:
382:
369:
281:
268:
170:
3484:
3454:
3396:
3195:
Genersch E, Eckerskorn C, Lottspeich F, Herzog C, Kühn K, Pöschl E (1995).
3133:
3081:
2904:
2851:
2842:
2825:
2810:
2761:
2753:
2725:
2716:
2699:
2684:
2675:
2658:
2643:
2634:
2617:
2602:
2553:
2544:
2527:
2512:
2503:
2486:
2471:
2404:
2363:
2314:
2213:
2131:
2079:
2038:
1989:
1971:
1940:
1881:
1822:
1482:
Mouse mutants with homozygous defects in Ku80 experience an early onset of
3605:
3570:
3527:
3492:
3462:
3433:
3404:
3375:
3337:
3308:
3273:
3230:
3187:
3162:"cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen"
3152:
3099:
3056:
3021:
2968:
2933:
2345:
2265:
2247:
2172:
1762:
1340:
1335:
2792:
1557:
1458:
which encodes Ku80. In a study of 87 matched pairs of primary tumors of
1402:
1324:
1167:
1148:
3329:
2871:"Dimerization, translocation and localization of Ku70 and Ku80 proteins"
2895:
2870:
1593:
1379:
1356:
1134:
1089:
3029:
Knuth MW, Gunderson SI, Thompson NE, Strasheim LA, Burgess RR (1990).
1434:
X-ray repair complementing defective repair in
Chinese hamster cells 5
103:
99:
95:
91:
87:
1587:
1563:
1308:
1044:
2526:
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (October 2002).
2659:"The human Rap1 protein complex and modulation of telomere length"
1795:
Lee MN, Tseng RC, Hsu HS, Chen JY, Tzao C, Ho WL, Wang YC (2007).
1575:
1007:
1003:
2698:
Chai W, Ford LP, Lenertz L, Wright WE, Shay JW (December 2002).
1581:
1569:
1367:
1363:
150:
3633:
2145:
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT (October 1997).
597:
3629:
1509:
in this gene is associated with cancer in patients of varying
1375:
2657:
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004).
3710:: The 3D solution structure of the C-terminal region of Ku86
2775:
Karmakar P, Snowden CM, Ramsden DA, Bohr VA (August 2002).
1954:
Didier N, Hourdé C, Amthor H, Marazzi G, Sassoon D (2012).
1838:"Deletion of Ku86 causes early onset of senescence in mice"
953:
positive regulation of telomere maintenance via telomerase
1836:
Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P (1999).
1474:
promoter hypermethylation but not with LOH of the gene.
1446:
The protein expression level of Ku80 can be repressed by
2377:
Song K, Jung D, Jung Y, Lee SG, Lee I (September 2000).
923:
double-strand break repair via nonhomologous end joining
406:
3578:
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT (1997).
1529:, and this was correlated with hypermethylation of the
3695:: Crystal Structure of the Ku heterodimer bound to DNA
1424:
Ku80 has been referred to by several names including:
1462:
and nearby normal lung tissue, 25% of the tumors had
571:
3064:
Stuiver MH, Coenjaerts FE, van der Vliet PC (1990).
1405:
length maintenance and subtelomeric gene silencing.
1401:
In addition to its role in NHEJ, Ku is required for
973:
protein localization to chromosome, telomeric region
1261:
1240:
1206:
1185:
893:
positive regulation of type I interferon production
888:
negative regulation of transcription, DNA-templated
1653:
1651:
1649:
1632:
1630:
1628:
353:
252:
1408:Ku was originally identified when patients with
3535:Myung K, He DM, Lee SE, Hendrickson EA (1997).
2186:
2184:
2182:
2091:
2089:
978:cellular response to leukemia inhibitory factor
2225:
2223:
1658:GRCm38: Ensembl release 89: ENSMUSG00000026187
963:positive regulation of protein kinase activity
843:regulation of smooth muscle cell proliferation
3645:
666:hydrolase activity, acting on acid anhydrides
8:
878:establishment of integrated proviral latency
2281:"Isolation of Ku70-binding proteins (KUBs)"
1637:GRCh38: Ensembl release 89: ENSG00000079246
3652:
3638:
3630:
1437:X-ray repair cross-complementing 5 (XRCC5)
1018:
968:positive regulation of telomerase activity
838:regulation of transcription, DNA-templated
613:
394:
293:
190:
76:
3725:: Three-dimensional structure of Ku80 CTD
3680:: Crystal Structure of the Ku Heterodimer
3595:
3560:
3517:
3298:
3263:
3220:
3177:
3160:Yaneva M, Wen J, Ayala A, Cook R (1989).
3142:
3132:
3089:
3046:
3011:
3001:
2958:
2894:
2841:
2800:
2715:
2674:
2633:
2592:
2543:
2502:
2461:
2451:
2394:
2353:
2304:
2255:
2162:
2121:
2069:
2028:
1979:
1930:
1920:
1871:
1861:
1812:
1752:
1708:
1706:
958:positive regulation of catalytic activity
873:negative regulation of t-circle formation
656:5'-deoxyribose-5-phosphate lyase activity
853:cellular response to DNA damage stimulus
3667:
3500:Warriar N, Pagé N, Govindan MV (1996).
1624:
898:cellular hyperosmotic salinity response
863:hematopoietic stem cell differentiation
2426:Ko L, Cardona GR, Chin WW (May 2000).
1612:Werner syndrome ATP-dependent helicase
1523:Deficient DNA repair in carcinogenesis
1431:ATP-dependent DNA helicase 2 subunit 2
31:
18:ATP-dependent DNA helicase 2 subunit 2
2379:"Interaction of human Ku70 with TRF2"
2096:Gell D, Jackson SP (September 1999).
1790:
1788:
1786:
1727:Boulton SJ, Jackson SP (March 1998).
641:double-stranded telomeric DNA binding
358:
319:
314:
257:
216:
211:
7:
983:activation of innate immune response
933:cellular response to gamma radiation
2567:Balajee AS, Geard CR (March 2001).
1359:that, in humans, is encoded by the
858:positive regulation of neurogenesis
3256:10.1002/j.1460-2075.1994.tb06826.x
3213:10.1002/j.1460-2075.1995.tb07057.x
1412:were found to have high levels of
1258:
1237:
1203:
1182:
1158:
1139:
1113:
1094:
1068:
1049:
948:regulation of telomere maintenance
716:protein-containing complex binding
576:
494:
432:
411:
25:
777:nonhomologous end joining complex
3715:
3700:
3685:
3670:
2824:Li B, Comai L (September 2000).
1600:Telomerase reverse transcriptase
1428:Lupus Ku autoantigen protein p80
691:ubiquitin protein ligase binding
587:
580:
342:
335:
329:
306:
241:
234:
228:
203:
40:
918:cellular response to fatty acid
598:More reference expression data
560:More reference expression data
1:
3443:Biochem. Biophys. Res. Commun
3300:10.1016/S0021-9258(17)32463-8
3179:10.1016/S0021-9258(18)80011-4
3048:10.1016/S0021-9258(18)38250-4
2960:10.1016/S0021-9258(18)42866-9
2742:Biochem. Biophys. Res. Commun
2396:10.1016/s0014-5793(00)01958-x
2206:10.1016/s0167-4781(02)00497-9
1814:10.1158/1078-0432.CCR-05-2694
1460:non-small-cell lung carcinoma
883:cell population proliferation
327:
226:
3426:10.1016/0378-1119(94)90802-8
3113:Proc. Natl. Acad. Sci. U.S.A
2982:Proc. Natl. Acad. Sci. U.S.A
2926:10.1016/0888-7543(92)90023-L
2485:Ko L, Chin WW (March 2003).
2432:Proc. Natl. Acad. Sci. U.S.A
1922:10.1371/journal.pone.0093568
1842:Proc. Natl. Acad. Sci. U.S.A
1410:systemic lupus erythematosus
848:transcription, DNA-templated
747:nuclear telomere cap complex
3746:Genes on human chromosome 2
1527:non-small cell lung cancers
1390:. It is also required for
696:double-stranded DNA binding
464:stromal cell of endometrium
3762:
1492:DNA damage theory of aging
1384:non-homologous end joining
938:cellular response to X-ray
868:double-strand break repair
807:protein-containing complex
671:protein C-terminus binding
3665:
2071:10.1038/modpathol.3880542
2021:10.1016/j.mad.2009.10.004
1693:"Mouse PubMed Reference:"
1675:"Human PubMed Reference:"
1339:
1334:
1330:
1323:
1307:
1294:Chr 2: 216.11 – 216.21 Mb
1288:
1265:
1244:
1233:
1210:
1189:
1178:
1165:
1161:
1146:
1142:
1133:
1120:
1116:
1101:
1097:
1088:
1075:
1071:
1056:
1052:
1043:
1028:
1021:
1017:
1001:
817:ribonucleoprotein complex
711:enzyme activator activity
616:
612:
595:
579:
570:
557:
506:
497:
444:
435:
405:
397:
393:
376:
363:
326:
305:
296:
292:
275:
262:
225:
202:
193:
189:
144:
141:
131:
124:
119:
84:
79:
62:
57:
52:
48:
39:
34:
3597:10.1074/jbc.272.40.24763
3553:10.1093/emboj/16.11.3172
3519:10.1074/jbc.271.31.18662
2164:10.1074/jbc.272.40.24763
1863:10.1073/pnas.96.19.10770
1450:hypermethylation of the
1382:and is required for the
928:neutrophil degranulation
3368:10.1126/science.8073286
3003:10.1073/pnas.89.14.6423
2453:10.1073/pnas.97.11.6212
1745:10.1093/emboj/17.6.1819
1548:Ku80 has been shown to
1301:Chr 1: 72.35 – 72.43 Mb
792:secretory granule lumen
29:Protein found in humans
3485:10.1006/geno.1995.9871
3455:10.1006/bbrc.1993.2339
3397:10.1006/geno.1994.1287
3134:10.1073/pnas.87.5.1777
3082:10.1084/jem.172.4.1049
2843:10.1074/jbc.C000289200
2754:10.1006/bbrc.1999.1978
2717:10.1074/jbc.M208542200
2676:10.1074/jbc.M312913200
2635:10.1074/jbc.M100768200
2545:10.1074/jbc.M206194200
2504:10.1074/jbc.M209723200
2297:10.1093/nar/27.10.2165
2194:Biochim. Biophys. Acta
2114:10.1093/nar/27.17.3494
1972:10.1002/emmm.201101075
1464:loss of heterozygosity
993:innate immune response
2585:10.1093/nar/29.6.1341
2346:10.1128/mcb.19.5.3267
2248:10.1128/mcb.18.3.1349
1498:Clinical significance
1442:Epigenetic repression
1370:and Ku80 make up the
988:immune system process
661:DNA helicase activity
646:telomeric DNA binding
1517:Deficiency in cancer
1378:double-strand break
943:telomere maintenance
908:DNA duplex unwinding
787:extracellular region
484:smooth muscle tissue
321:Chromosome 1 (mouse)
219:Chromosome 2 (human)
80:List of PDB id codes
53:Available structures
3360:1994Sci...265.1442T
3330:10.1021/bi00194a021
3125:1990PNAS...87.1777M
2994:1992PNAS...89.6423J
2887:2002JRadR..43..223K
2444:2000PNAS...97.6212K
1913:2014PLoSO...993568R
1854:1999PNAS...9610770V
1392:V(D)J recombination
797:protein-DNA complex
701:damaged DNA binding
460:islet of Langerhans
452:ganglionic eminence
360:1 C3|1 36.5 cM
2896:10.1269/jrr.43.223
2793:10.1093/nar/gkf482
1538:Cancer epigenetics
1386:(NHEJ) pathway of
1123:ENSMUSG00000026187
826:Biological process
812:site of DNA damage
730:Cellular component
681:hydrolase activity
636:nucleotide binding
624:Molecular function
3733:
3732:
3250:(20): 4991–5001.
2781:Nucleic Acids Res
2573:Nucleic Acids Res
2285:Nucleic Acids Res
2102:Nucleic Acids Res
2015:(11–12): 784–92.
1606:Tyrosine kinase 2
1488:species longevity
1374:, which binds to
1350:
1349:
1346:
1345:
1319:
1318:
1284:
1283:
1255:
1254:
1229:
1228:
1200:
1199:
1174:
1173:
1155:
1154:
1129:
1128:
1110:
1109:
1084:
1083:
1065:
1064:
1013:
1012:
913:brain development
833:DNA recombination
802:Ku70:Ku80 complex
651:helicase activity
608:
607:
604:
603:
566:
565:
553:
552:
491:
490:
480:bone marrow cells
389:
388:
288:
287:
183:XRCC5 - orthologs
115:
114:
111:
110:
63:Ortholog search:
16:(Redirected from
3753:
3719:
3704:
3689:
3674:
3654:
3647:
3640:
3631:
3609:
3599:
3574:
3564:
3531:
3521:
3512:(31): 18662–71.
3496:
3466:
3437:
3408:
3379:
3354:(5177): 1442–5.
3341:
3312:
3302:
3277:
3267:
3234:
3224:
3191:
3181:
3172:(23): 13407–11.
3156:
3146:
3136:
3103:
3093:
3060:
3050:
3041:(29): 17911–20.
3025:
3015:
3005:
2972:
2962:
2937:
2908:
2898:
2869:Koike M (2003).
2856:
2855:
2845:
2836:(37): 28349–52.
2821:
2815:
2814:
2804:
2772:
2766:
2765:
2736:
2730:
2729:
2719:
2695:
2689:
2688:
2678:
2669:(27): 28585–91.
2654:
2648:
2647:
2637:
2628:(20): 16848–56.
2613:
2607:
2606:
2596:
2564:
2558:
2557:
2547:
2523:
2517:
2516:
2506:
2482:
2476:
2475:
2465:
2455:
2423:
2417:
2416:
2398:
2374:
2368:
2367:
2357:
2325:
2319:
2318:
2308:
2276:
2270:
2269:
2259:
2227:
2218:
2217:
2188:
2177:
2176:
2166:
2142:
2136:
2135:
2125:
2108:(17): 3494–502.
2093:
2084:
2083:
2073:
2049:
2043:
2042:
2032:
2009:Mech. Ageing Dev
2000:
1994:
1993:
1983:
1951:
1945:
1944:
1934:
1924:
1892:
1886:
1885:
1875:
1865:
1833:
1827:
1826:
1816:
1801:Clin. Cancer Res
1792:
1781:
1780:
1773:
1767:
1766:
1756:
1724:
1718:
1717:
1710:
1701:
1700:
1689:
1683:
1682:
1671:
1665:
1655:
1644:
1634:
1511:radiosensitivity
1416:to the protein.
1332:
1331:
1303:
1296:
1279:
1259:
1250:
1238:
1234:RefSeq (protein)
1224:
1204:
1195:
1183:
1159:
1140:
1114:
1095:
1069:
1050:
1019:
614:
600:
591:
584:
577:
562:
546:primitive streak
542:ventricular zone
522:genital tubercle
502:
500:Top expressed in
495:
456:ventricular zone
440:
438:Top expressed in
433:
412:
395:
385:
372:
361:
346:
339:
333:
322:
310:
294:
284:
271:
260:
245:
238:
232:
221:
207:
191:
185:
136:
129:
106:
77:
71:
50:
49:
44:
32:
21:
3761:
3760:
3756:
3755:
3754:
3752:
3751:
3750:
3736:
3735:
3734:
3729:
3726:
3720:
3711:
3705:
3696:
3690:
3681:
3675:
3661:
3658:
3627:
3617:
3612:
3590:(40): 24763–6.
3577:
3547:(11): 3172–84.
3534:
3499:
3469:
3440:
3411:
3382:
3344:
3324:(28): 8548–57.
3315:
3293:(26): 17464–8.
3280:
3237:
3194:
3159:
3106:
3063:
3028:
2975:
2940:
2911:
2868:
2864:
2862:Further reading
2859:
2823:
2822:
2818:
2787:(16): 3583–91.
2774:
2773:
2769:
2738:
2737:
2733:
2710:(49): 47242–7.
2697:
2696:
2692:
2656:
2655:
2651:
2615:
2614:
2610:
2566:
2565:
2561:
2538:(43): 40362–7.
2525:
2524:
2520:
2497:(13): 11471–9.
2484:
2483:
2479:
2425:
2424:
2420:
2376:
2375:
2371:
2334:Mol. Cell. Biol
2327:
2326:
2322:
2291:(10): 2165–74.
2278:
2277:
2273:
2236:Mol. Cell. Biol
2229:
2228:
2221:
2190:
2189:
2180:
2157:(40): 24763–6.
2144:
2143:
2139:
2095:
2094:
2087:
2051:
2050:
2046:
2002:
2001:
1997:
1953:
1952:
1948:
1894:
1893:
1889:
1848:(19): 10770–5.
1835:
1834:
1830:
1794:
1793:
1784:
1775:
1774:
1770:
1726:
1725:
1721:
1712:
1711:
1704:
1691:
1690:
1686:
1673:
1672:
1668:
1656:
1647:
1635:
1626:
1622:
1617:
1546:
1519:
1500:
1480:
1452:promoter region
1444:
1422:
1341:View/Edit Mouse
1336:View/Edit Human
1299:
1292:
1289:Location (UCSC)
1275:
1271:
1267:
1246:
1220:
1216:
1212:
1191:
1104:ENSG00000079246
997:
821:
757:plasma membrane
725:
721:DNA end binding
676:protein binding
596:
586:
585:
558:
549:
544:
540:
536:
532:
528:
524:
520:
516:
512:
498:
487:
482:
478:
476:Achilles tendon
474:
470:
466:
462:
458:
454:
450:
436:
380:
367:
359:
349:
348:
347:
340:
320:
297:Gene location (
279:
266:
258:
248:
247:
246:
239:
217:
194:Gene location (
145:
132:
125:
86:
64:
30:
23:
22:
15:
12:
11:
5:
3759:
3757:
3749:
3748:
3738:
3737:
3731:
3730:
3728:
3727:
3721:
3714:
3712:
3706:
3699:
3697:
3691:
3684:
3682:
3676:
3669:
3666:
3663:
3662:
3659:
3657:
3656:
3649:
3642:
3634:
3625:
3624:
3616:
3615:External links
3613:
3611:
3610:
3575:
3532:
3497:
3467:
3438:
3420:(1–2): 171–4.
3409:
3380:
3342:
3313:
3278:
3235:
3207:(4): 791–800.
3192:
3157:
3119:(5): 1777–81.
3104:
3076:(4): 1049–54.
3061:
3026:
2988:(14): 6423–7.
2973:
2953:(7): 4533–40.
2938:
2920:(4): 1088–94.
2909:
2875:J. Radiat. Res
2865:
2863:
2860:
2858:
2857:
2816:
2767:
2731:
2690:
2649:
2608:
2579:(6): 1341–51.
2559:
2518:
2477:
2438:(11): 6212–7.
2418:
2369:
2340:(5): 3267–77.
2320:
2271:
2242:(3): 1349–58.
2219:
2200:(1–3): 59–72.
2178:
2137:
2085:
2044:
1995:
1946:
1887:
1828:
1782:
1768:
1739:(6): 1819–28.
1719:
1702:
1684:
1666:
1645:
1623:
1621:
1618:
1616:
1615:
1609:
1603:
1597:
1591:
1585:
1579:
1573:
1567:
1561:
1554:
1545:
1542:
1518:
1515:
1504:microsatellite
1499:
1496:
1479:
1476:
1443:
1440:
1439:
1438:
1435:
1432:
1429:
1421:
1418:
1414:autoantibodies
1372:Ku heterodimer
1348:
1347:
1344:
1343:
1338:
1328:
1327:
1321:
1320:
1317:
1316:
1314:
1312:
1305:
1304:
1297:
1290:
1286:
1285:
1282:
1281:
1263:
1262:
1256:
1253:
1252:
1242:
1241:
1235:
1231:
1230:
1227:
1226:
1208:
1207:
1201:
1198:
1197:
1187:
1186:
1180:
1176:
1175:
1172:
1171:
1163:
1162:
1156:
1153:
1152:
1144:
1143:
1137:
1131:
1130:
1127:
1126:
1118:
1117:
1111:
1108:
1107:
1099:
1098:
1092:
1086:
1085:
1082:
1081:
1073:
1072:
1066:
1063:
1062:
1054:
1053:
1047:
1041:
1040:
1035:
1030:
1026:
1025:
1015:
1014:
1011:
1010:
999:
998:
996:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
829:
827:
823:
822:
820:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
733:
731:
727:
726:
724:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
627:
625:
621:
620:
610:
609:
606:
605:
602:
601:
593:
592:
574:
568:
567:
564:
563:
555:
554:
551:
550:
548:
547:
543:
539:
535:
531:
530:primary oocyte
527:
526:tail of embryo
523:
519:
515:
511:
507:
504:
503:
492:
489:
488:
486:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
442:
441:
429:
428:
420:
409:
403:
402:
399:RNA expression
391:
390:
387:
386:
378:
374:
373:
365:
362:
357:
351:
350:
341:
334:
328:
324:
323:
318:
312:
311:
303:
302:
290:
289:
286:
285:
277:
273:
272:
264:
261:
256:
250:
249:
240:
233:
227:
223:
222:
215:
209:
208:
200:
199:
187:
186:
143:
139:
138:
130:
122:
121:
117:
116:
113:
112:
109:
108:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3758:
3747:
3744:
3743:
3741:
3724:
3718:
3713:
3709:
3703:
3698:
3694:
3688:
3683:
3679:
3673:
3668:
3664:
3655:
3650:
3648:
3643:
3641:
3636:
3635:
3632:
3628:
3622:
3619:
3618:
3614:
3607:
3603:
3598:
3593:
3589:
3585:
3584:J. Biol. Chem
3581:
3576:
3572:
3568:
3563:
3558:
3554:
3550:
3546:
3542:
3538:
3533:
3529:
3525:
3520:
3515:
3511:
3507:
3506:J. Biol. Chem
3503:
3498:
3494:
3490:
3486:
3482:
3478:
3474:
3468:
3464:
3460:
3456:
3452:
3449:(2): 935–42.
3448:
3444:
3439:
3435:
3431:
3427:
3423:
3419:
3415:
3410:
3406:
3402:
3398:
3394:
3390:
3386:
3381:
3377:
3373:
3369:
3365:
3361:
3357:
3353:
3349:
3343:
3339:
3335:
3331:
3327:
3323:
3319:
3314:
3310:
3306:
3301:
3296:
3292:
3288:
3287:J. Biol. Chem
3284:
3279:
3275:
3271:
3266:
3261:
3257:
3253:
3249:
3245:
3241:
3236:
3232:
3228:
3223:
3218:
3214:
3210:
3206:
3202:
3198:
3193:
3189:
3185:
3180:
3175:
3171:
3167:
3166:J. Biol. Chem
3163:
3158:
3154:
3150:
3145:
3140:
3135:
3130:
3126:
3122:
3118:
3114:
3110:
3105:
3101:
3097:
3092:
3087:
3083:
3079:
3075:
3071:
3067:
3062:
3058:
3054:
3049:
3044:
3040:
3036:
3035:J. Biol. Chem
3032:
3027:
3023:
3019:
3014:
3009:
3004:
2999:
2995:
2991:
2987:
2983:
2979:
2974:
2970:
2966:
2961:
2956:
2952:
2948:
2947:J. Biol. Chem
2944:
2939:
2935:
2931:
2927:
2923:
2919:
2915:
2910:
2906:
2902:
2897:
2892:
2888:
2884:
2881:(3): 223–36.
2880:
2876:
2872:
2867:
2866:
2861:
2853:
2849:
2844:
2839:
2835:
2831:
2830:J. Biol. Chem
2827:
2820:
2817:
2812:
2808:
2803:
2798:
2794:
2790:
2786:
2782:
2778:
2771:
2768:
2763:
2759:
2755:
2751:
2747:
2743:
2735:
2732:
2727:
2723:
2718:
2713:
2709:
2705:
2704:J. Biol. Chem
2701:
2694:
2691:
2686:
2682:
2677:
2672:
2668:
2664:
2663:J. Biol. Chem
2660:
2653:
2650:
2645:
2641:
2636:
2631:
2627:
2623:
2622:J. Biol. Chem
2619:
2612:
2609:
2604:
2600:
2595:
2590:
2586:
2582:
2578:
2574:
2570:
2563:
2560:
2555:
2551:
2546:
2541:
2537:
2533:
2532:J. Biol. Chem
2529:
2522:
2519:
2514:
2510:
2505:
2500:
2496:
2492:
2491:J. Biol. Chem
2488:
2481:
2478:
2473:
2469:
2464:
2459:
2454:
2449:
2445:
2441:
2437:
2433:
2429:
2422:
2419:
2414:
2410:
2406:
2402:
2397:
2392:
2388:
2384:
2380:
2373:
2370:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2335:
2331:
2324:
2321:
2316:
2312:
2307:
2302:
2298:
2294:
2290:
2286:
2282:
2275:
2272:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2224:
2220:
2215:
2211:
2207:
2203:
2199:
2195:
2187:
2185:
2183:
2179:
2174:
2170:
2165:
2160:
2156:
2152:
2151:J. Biol. Chem
2148:
2141:
2138:
2133:
2129:
2124:
2119:
2115:
2111:
2107:
2103:
2099:
2092:
2090:
2086:
2081:
2077:
2072:
2067:
2064:(4): 426–33.
2063:
2059:
2055:
2048:
2045:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
1999:
1996:
1991:
1987:
1982:
1977:
1973:
1969:
1966:(9): 910–23.
1965:
1961:
1957:
1950:
1947:
1942:
1938:
1933:
1928:
1923:
1918:
1914:
1910:
1907:(4): e93568.
1906:
1902:
1898:
1891:
1888:
1883:
1879:
1874:
1869:
1864:
1859:
1855:
1851:
1847:
1843:
1839:
1832:
1829:
1824:
1820:
1815:
1810:
1806:
1802:
1798:
1791:
1789:
1787:
1783:
1778:
1772:
1769:
1764:
1760:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1723:
1720:
1715:
1709:
1707:
1703:
1698:
1694:
1688:
1685:
1680:
1676:
1670:
1667:
1663:
1659:
1654:
1652:
1650:
1646:
1642:
1638:
1633:
1631:
1629:
1625:
1619:
1613:
1610:
1607:
1604:
1601:
1598:
1595:
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1396:immune system
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1179:RefSeq (mRNA)
1177:
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1157:
1151:
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623:
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618:Gene ontology
615:
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128:
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118:
107:
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97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
3722:
3707:
3692:
3677:
3626:
3587:
3583:
3544:
3540:
3509:
3505:
3479:(2): 320–8.
3476:
3472:
3446:
3442:
3417:
3413:
3391:(2): 423–7.
3388:
3384:
3351:
3347:
3321:
3318:Biochemistry
3317:
3290:
3286:
3247:
3243:
3204:
3200:
3169:
3165:
3116:
3112:
3073:
3069:
3038:
3034:
2985:
2981:
2950:
2946:
2917:
2913:
2878:
2874:
2833:
2829:
2819:
2784:
2780:
2770:
2748:(3): 692–6.
2745:
2741:
2734:
2707:
2703:
2693:
2666:
2662:
2652:
2625:
2621:
2611:
2576:
2572:
2562:
2535:
2531:
2521:
2494:
2490:
2480:
2435:
2431:
2421:
2386:
2382:
2372:
2337:
2333:
2323:
2288:
2284:
2274:
2239:
2235:
2197:
2193:
2154:
2150:
2140:
2105:
2101:
2061:
2057:
2047:
2012:
2008:
1998:
1963:
1960:EMBO Mol Med
1959:
1949:
1904:
1900:
1890:
1845:
1841:
1831:
1807:(3): 832–8.
1804:
1800:
1771:
1736:
1732:
1722:
1696:
1687:
1678:
1669:
1547:
1544:Interactions
1535:
1530:
1520:
1507:polymorphism
1501:
1481:
1471:
1467:
1455:
1445:
1423:
1420:Nomenclature
1407:
1400:
1360:
1352:
1351:
1277:NP_001344449
1273:NP_001344448
1266:
1245:
1222:NM_001357520
1218:NM_001357519
1211:
1190:
1166:
1147:
1121:
1102:
1076:
1057:
1037:
1032:
538:right kidney
518:otic vesicle
514:otic placode
422:
415:
280:216,206,303
267:216,107,464
142:External IDs
85:
26:
3660:PDB gallery
3070:J. Exp. Med
2389:(1): 81–5.
2058:Mod. Pathol
762:nucleoplasm
706:RNA binding
686:ATP binding
631:DNA binding
468:bone marrow
381:72,434,111
368:72,346,586
120:Identifiers
1664:, May 2017
1643:, May 2017
1620:References
1533:promoter.
1484:senescence
1478:Senescence
1448:epigenetic
1388:DNA repair
903:DNA repair
767:chromosome
426:(ortholog)
163:HomoloGene
2383:FEBS Lett
1454:of gene
1269:NP_033559
1248:NP_066964
1214:NM_009533
1193:NM_021141
1023:Orthologs
772:nucleolus
737:cytoplasm
171:GeneCards
3740:Category
3473:Genomics
3385:Genomics
2914:Genomics
2905:12518983
2852:10880505
2811:12177300
2762:10673353
2726:12377759
2685:15100233
2644:11279128
2603:11239001
2554:12171929
2513:12519782
2472:10823961
2413:22753893
2405:10984620
2364:10207052
2315:10219089
2214:12393188
2132:10446239
2080:11950917
2039:19896964
1990:22915554
1941:24740260
1901:PLOS ONE
1882:10485901
1823:17289874
1660:–
1639:–
1558:DNA-PKcs
1550:interact
1403:telomere
1325:Wikidata
1002:Sources:
752:membrane
534:epiblast
3621:PDBe-KB
3606:9312071
3571:9214634
3562:1169935
3528:8702520
3493:8586433
3463:8240370
3434:8125298
3405:8088837
3376:8073286
3356:Bibcode
3348:Science
3338:8031790
3309:8021251
3274:7957065
3231:7882982
3188:2760028
3153:2308937
3121:Bibcode
3100:2212941
3091:2188621
3057:2211668
3022:1631138
2990:Bibcode
2969:1537839
2934:1505945
2883:Bibcode
2440:Bibcode
2266:9488450
2173:9312071
2030:2799038
1981:3491824
1932:3989187
1909:Bibcode
1850:Bibcode
1763:9501103
1754:1170529
1662:Ensembl
1641:Ensembl
1594:TERF2IP
1502:A rare
1357:protein
1135:UniProt
1090:Ensembl
1029:Species
1008:QuickGO
782:nucleus
742:cytosol
510:saccule
401:pattern
127:Aliases
3604:
3569:
3559:
3541:EMBO J
3526:
3491:
3461:
3432:
3403:
3374:
3336:
3307:
3272:
3265:395441
3262:
3244:EMBO J
3229:
3222:398145
3219:
3201:EMBO J
3186:
3151:
3141:
3098:
3088:
3055:
3020:
3010:
2967:
2932:
2903:
2850:
2809:
2802:134248
2799:
2760:
2724:
2683:
2642:
2601:
2591:
2552:
2511:
2470:
2460:
2411:
2403:
2362:
2352:
2313:
2306:148436
2303:
2264:
2257:108848
2254:
2212:
2171:
2130:
2123:148593
2120:
2078:
2037:
2027:
1988:
1978:
1939:
1929:
1880:
1870:
1821:
1761:
1751:
1733:EMBO J
1608:, and
1588:POU2F1
1564:GCN5L2
1552:with:
1311:search
1309:PubMed
1168:P27641
1149:P13010
1045:Entrez
572:BioGPS
448:embryo
159:104517
151:194364
3144:53566
3013:49513
2594:29758
2463:18584
2409:S2CID
2355:84121
1873:17958
1576:NCOA6
1531:XRCC5
1472:XRCC5
1468:XRCC5
1456:XRCC5
1361:XRCC5
1355:is a
1078:22596
1038:Mouse
1033:Human
1004:Amigo
472:gonad
424:Mouse
417:Human
364:Start
299:Mouse
263:Start
196:Human
175:XRCC5
167:40681
134:XRCC5
35:XRCC5
3723:1rw2
3708:1q2z
3693:1jey
3678:1jeq
3602:PMID
3567:PMID
3524:PMID
3489:PMID
3459:PMID
3430:PMID
3414:Gene
3401:PMID
3372:PMID
3334:PMID
3305:PMID
3270:PMID
3227:PMID
3184:PMID
3149:PMID
3096:PMID
3053:PMID
3018:PMID
2965:PMID
2930:PMID
2901:PMID
2848:PMID
2807:PMID
2758:PMID
2722:PMID
2681:PMID
2640:PMID
2599:PMID
2550:PMID
2509:PMID
2468:PMID
2401:PMID
2360:PMID
2311:PMID
2262:PMID
2210:PMID
2198:1578
2169:PMID
2128:PMID
2076:PMID
2035:PMID
1986:PMID
1937:PMID
1878:PMID
1819:PMID
1759:PMID
1582:PCNA
1570:Ku70
1380:ends
1368:Ku70
1364:gene
1353:Ku80
1059:7520
407:Bgee
355:Band
316:Chr.
259:2q35
254:Band
213:Chr.
147:OMIM
104:3RZ9
100:1RW2
96:1Q2Z
92:1JEY
88:1JEQ
69:RCSB
66:PDBe
3592:doi
3588:272
3557:PMC
3549:doi
3514:doi
3510:271
3481:doi
3451:doi
3447:196
3422:doi
3418:138
3393:doi
3364:doi
3352:265
3326:doi
3295:doi
3291:269
3260:PMC
3252:doi
3217:PMC
3209:doi
3174:doi
3170:264
3139:PMC
3129:doi
3086:PMC
3078:doi
3074:172
3043:doi
3039:265
3008:PMC
2998:doi
2955:doi
2951:267
2922:doi
2891:doi
2838:doi
2834:275
2797:PMC
2789:doi
2750:doi
2746:267
2712:doi
2708:277
2671:doi
2667:279
2630:doi
2626:276
2589:PMC
2581:doi
2540:doi
2536:277
2499:doi
2495:278
2458:PMC
2448:doi
2391:doi
2387:481
2350:PMC
2342:doi
2301:PMC
2293:doi
2252:PMC
2244:doi
2202:doi
2159:doi
2155:272
2118:PMC
2110:doi
2066:doi
2025:PMC
2017:doi
2013:130
1976:PMC
1968:doi
1927:PMC
1917:doi
1868:PMC
1858:doi
1809:doi
1749:PMC
1741:doi
1540:).
1494:).
1376:DNA
377:End
276:End
179:OMA
155:MGI
59:PDB
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