709:
686:
3935:
583:
608:
3890:
3815:
967:
960:
3845:
3800:
3875:
2023:. It is directly involved in the interaction of the kinetochore, the part of the chromosome at which the mitotic spindle attaches and pulls, and the mitotic spindle's extended microtubules. It is speculated that Aurora B cooperates with Aurora A to complete this task. In the absence of Aurora A mad2, a protein that normally dissipates once a proper kinetochore-microtubule connection is made, remains present even into metaphase.
3830:
715:
614:
3920:
3905:
40:
3860:
3785:
6112:
2078:, Aurora A induces the synthesis of MOS. The MOS protein accumulates until it exceeds a threshold and then transduces the phosphorylation cascade in the map kinase pathway. This signal subsequently activates the kinase RSK which in turn binds to the protein Myt1. Myt1, in complex with RSK, is now unable to inhibit
2034:
returns to the mid-body of the mitotic cell at the end of mitosis and causes the central microtubules to release from the mid-body. The release allows mitosis to run to completion. Though the exact mechanism by which Aurora A aids cytokinesis is unknown, it is well documented that it relocalizes to
2103:
Aurora A dysregulation has been associated with high occurrence of cancer. For example, one study showed over-expression of Aurora A in 94 percent of the invasive tissue growth in breast cancer, while surrounding, healthy tissues had normal levels of Aurora A expression. Aurora A has also been shown
2011:
Furthermore, Aurora A is necessary for the proper separation of the centrosomes after the mitotic spindle has been formed. Without Aurora A, the mitotic spindle, depending on the organism, will either never separate or will begin to separate only to collapse back onto itself. In the case of the
1983:
is assembled by using microtubules to tether together the mother centrosome to its daughter. The resulting mitotic spindle is then used to propel apart the sister chromosomes into what will become the two new daughter cells. Aurora A is critical for proper formation of mitotic spindle. It is
3001:
Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A (August 2003). "Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human".
2085:
Furthermore, Aurora A has been observed to have a biphasic pattern of activation during progression through meiosis. It has been suggested that the fluctuations, or phases, of Aurora A activation are dependent on a positive-feedback mechanism with a p13SUC1-associated protein kinase
66:
3151:
Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert DJ, Jenkins NA, Copeland NG, Yagita H, Okumura K (1998). "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2".
2054:, flies without Aurora A will effectively form spindles and separate but the aster microtubules will be dwarfed. These observations suggests that while Aurora-A has orthologues in many different organisms, it may play a similar but slightly different role in each.
2730:
Otto, Tobias; Horn, Sebastian; Brockmann, Markus; Eilers, Ursula; SchĂĽttrumpf, Lars; Popov, Nikita; Kenney, Anna Marie; Schulte, Johannes H.; Beijersbergen, Roderick; Christiansen, Holger; Berwanger, Bernd; Eilers, Martin (2009).
3049:
Ferchichi I, Stambouli N, Marrackchi R, Arlot Y, Prigent C, Fadiel A, Odunsi K, Ben Ammar
Elgaaied A, Hamza A (January 2010). "Experimental and computational studies indicate specific binding of pVHL protein to Aurora-A kinase".
2148:, which initially kills cancerous tumors, but the tumors rewire and activate Aurora kinase A, becoming cancerous growths again. According to a 2018 study, targeting both EGFR and Aurora prevents return of drug resistant tumors.
2094:
Aurora A is not only implicated with the translation of MOS during meiosis but also in the polyadenylation and subsequent translation of neural mRNAs whose protein products are associated with synaptic plasticity.
3934:
1967:. As the cell cycle progresses, concentrations of Aurora A increase and the kinase associates with the mitotic poles and the adjacent spindle microtubules. Aurora A remains associated with the spindles through
3975:
4260:
2341:
Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S (October 1998). "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation".
3889:
3968:
2123:- containing more chromosomes than normal. Aneuploidy is a trait of many cancerous tumors. Ordinarily, Aurora A expression levels are kept in check by the tumor suppressor protein
3181:
Kimura M, Matsuda Y, Eki T, Yoshioka T, Okumura K, Hanaoka F, Okano Y (1997). "Assignment of STK6 to human chromosome 20q13.2-->q13.3 and a pseudogene STK6P to 1q41-->q42".
3814:
2016:
s to dissolve the structure tethering the cell's centrosomes together. Therefore, without proper expression of Aurora A, the cell's centrosomes are never able to separate.
3961:
4168:
722:
621:
3542:"Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells"
2000:, are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of Îł-tubulin that normal centrosomes recruit prior to entering
2626:"Androgen-targeted therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for intervention"
4716:
5555:
4019:
3844:
1940:. The Aurora kinase A is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. The Aurora kinase B is a
3799:
5664:
4402:
4289:
1874:
eggs. The kinase discovered, Eg2, is now referred to as Aurora A. However, Aurora A's meiotic and mitotic significance was not recognized until 1998.
1480:
4677:
3874:
1461:
544:
5650:
5115:
4006:
3988:
3118:"Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1"
1833:
5752:
5633:
2082:. As a consequence, cdc2 permits entry into meiosis. A similar Aurora A dependent process regulates the transition from meiosis I-meiosis II.
5339:
4208:
3829:
2105:
6132:
5403:
4378:
3764:
2282:
2302:"A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines"
2264:
5659:
3919:
3904:
1951:
Although there is evidence to suggest that Aurora C might be a chromosomal passenger protein, the cellular function of it is less clear.
4193:
1984:
required for the recruitment of several different proteins important to the spindle formation. Among these target proteins are TACC, a
3859:
2004:. Though the cell cycle continues even in the absence of sufficient Îł-tubulin, the centrosome never fully matures; it organizes fewer
708:
5716:
5391:
3712:
3386:"Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle"
1759:
1752:
3784:
2911:
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, SĂ©raphin B, Jacquemier J, Birnbaum D (November 2003).
5831:
4648:
4638:
4323:
685:
5330:
2145:
2042:
interference results in different mutant phenotypes in different organisms and cell types. For example, deletion of Aurora A in
5599:
5271:
4633:
4624:
2251:
2230:
3943:: Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
607:
582:
5987:
2247:
3718:
63:
5014:
4511:
4502:
4159:
4105:
6102:
2675:
2226:
4202:
2030:- the process by which the cytoplasm of the parent cell is split into two daughter cells. During cytokinesis the mother
524:
2119:. If the cell begins mitosis, duplicates its DNA, but is then not able to divide into two separate cells it becomes an
2157:
2130:
Mutations of the chromosome region that contains Aurora A, 20q13, are generally considered to have a poor prognosis.
1836:. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy
721:
620:
3953:
5226:
5044:
4540:
5972:
714:
613:
6088:
6075:
6062:
6049:
6036:
6023:
6010:
5216:
5211:
5206:
5196:
5191:
5186:
5176:
4971:
4746:
4342:
3757:
5982:
3499:"Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells"
2046:
results in an initial separation of the cell's centrosomes followed by an immediate collapse of the asters. In
6147:
5936:
5879:
5439:
5430:
5381:
4147:
3992:
2691:"MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase"
2067:
1525:
532:
3464:"Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1"
5884:
5739:
5162:
1506:
1910:
5905:
5824:
4438:
596:
5977:
2519:"Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes"
5005:
3898:: AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH A 5-AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR
3750:
3223:
2005:
511:
3739:
provides an overview of all the structure information available in the PDB for Mouse Aurora kinase A
3733:
provides an overview of all the structure information available in the PDB for Human Aurora kinase A
6137:
5941:
3724:
1731:
1680:
1676:
1672:
1652:
1627:
1623:
1619:
5513:
2870:
Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (June 2004).
6142:
5874:
5616:
5570:
3663:"Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function"
3419:
Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002).
3343:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
3265:"The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation"
3104:
3027:
2823:"Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function"
2436:
2366:
1837:
556:
2115:
Dysregulation of Aurora A may lead to cancer because Aurora A is required for the completion of
1735:
1710:
1706:
1702:
1698:
1688:
1684:
1648:
1615:
1605:
1601:
1597:
1593:
1589:
3421:"Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases"
4876:
4585:
3692:
3649:
3606:
3571:
3528:
3485:
3450:
3407:
3372:
3329:
3286:
3251:
3198:
3169:
3139:
3096:
3067:
3019:
2983:
2934:
2893:
2852:
2803:
2754:
2712:
2657:
2606:
2548:
2492:
2428:
2358:
2323:
2026:
Finally, Aurora A helps orchestrate an exit from mitosis by contributing to the completion of
966:
959:
504:
56:
1346:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5920:
5915:
5889:
5817:
5469:
4711:
4701:
4696:
4614:
4605:
4535:
4526:
4472:
4463:
4120:
3682:
3674:
3639:
3631:
3596:
3561:
3553:
3518:
3510:
3475:
3440:
3432:
3397:
3362:
3354:
3319:
3311:
3276:
3241:
3231:
3190:
3161:
3129:
3088:
3059:
3011:
2973:
2965:
2924:
2883:
2842:
2834:
2793:
2785:
2744:
2702:
2689:
Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (December 2002).
2647:
2637:
2596:
2538:
2530:
2482:
2474:
2418:
2350:
2313:
801:
732:
676:
631:
552:
5967:
5951:
5864:
5295:
4366:
4361:
4356:
2774:"The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1"
2109:
2063:
1980:
1891:
1841:
776:
3823:: STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43
3227:
6116:
6005:
5946:
3644:
3619:
3566:
3541:
3367:
3342:
2978:
2953:
2652:
2625:
2585:"Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells"
2487:
2462:
39:
3687:
3662:
3523:
3498:
3445:
3420:
3324:
3299:
3079:
Nigg EA (2001). "Mitotic kinases as regulators of cell division and its checkpoints".
2847:
2822:
2798:
2773:
2543:
2518:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
6126:
5910:
5869:
4419:
4351:
3736:
3730:
3246:
3211:
3108:
1887:
1861:
995:
3462:
Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y (2002).
3031:
2534:
2440:
2370:
5859:
5290:
4115:
3585:"Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins"
2583:
Marumoto T, Honda S, Hara T, Nitta M, Hirota T, Kohmura E, Saya H (December 2003).
2020:
794:
573:
536:
3436:
3358:
2733:"Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma"
2423:
2406:
2019:
Aurora A also assures proper organization and alignment of the chromosomes during
1993:
1971:. Right before mitotic exit, Aurora A relocalizes to the mid-zone of the spindle.
2463:"Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans"
560:
6083:
6018:
5854:
5496:
5128:
5068:
4951:
4871:
4595:
3557:
2287:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2269:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2141:
2137:
2133:
2116:
2027:
1985:
1945:
1326:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
6111:
3116:
Kimura M, Kotani S, Hattori T, Sumi N, Yoshioka T, Todokoro K, Okano Y (1997).
2012:
former, it has been suggested that Aurora A cooperates with the kinase Nek2 in
1933:
domains, however, exhibit a large degree of variance in the size and sequence.
877:
5584:
4058:
2749:
2732:
1997:
1992:
5, a motor protein involved in the formation of the bipolar mitotic spindle.
1941:
1930:
1926:
1925:
during different phases of mitosis. The family members have highly conserved
1922:
1915:
1904:
693:
590:
540:
3514:
3134:
3117:
2758:
515:, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A
6057:
6031:
4545:
3236:
2642:
2624:
Nouri M, Ratther E, Stylianou N, Nelson CC, Hollier BG, Williams ED (2014).
2120:
2075:
2031:
1968:
1425:
937:
815:
760:
747:
659:
646:
548:
3696:
3678:
3653:
3610:
3601:
3584:
3575:
3532:
3489:
3480:
3463:
3454:
3411:
3402:
3385:
3376:
3333:
3290:
3281:
3264:
3255:
3165:
3100:
3071:
3023:
2987:
2952:
Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA (August 2002).
2938:
2929:
2912:
2897:
2888:
2871:
2856:
2838:
2807:
2716:
2707:
2690:
2661:
2610:
2601:
2584:
2552:
2496:
2432:
2318:
2301:
3635:
3202:
3173:
3143:
2969:
2478:
2362:
2327:
1799:
1794:
4901:
4796:
4791:
4786:
2789:
2001:
1960:
1921:
In all studied species, the three Aurora mitotic kinases localize to the
1845:
1783:
1570:
1551:
2050:, deletion disallows the mitotic spindle from ever even forming. And in
5560:
5538:
5533:
5523:
5518:
5320:
5315:
5310:
5305:
5300:
5285:
5280:
4931:
4896:
4135:
4130:
4125:
3341:
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000).
1989:
1964:
1937:
1870:
1849:
1537:
1492:
3853:: STRUCTURE OF HUMAN AURORA-A 122-403 PHOSPHORYLATED ON THR287, THR288
3315:
3194:
3063:
2676:"Cancer researchers identify 'Achilles heel' of drug-resistant tumors"
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
6070:
5840:
5790:
5785:
5780:
5775:
5770:
5765:
5760:
5711:
5706:
5701:
5696:
5691:
5674:
5669:
5543:
5528:
5479:
5474:
5459:
5454:
5449:
5444:
5418:
5413:
5408:
5396:
5374:
5369:
5261:
5236:
4911:
4736:
4731:
4726:
4721:
4706:
4550:
4487:
4482:
4477:
4453:
4279:
4274:
4248:
4243:
4238:
4228:
4223:
4213:
4053:
3984:
3808:: CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE
3620:"Human TPX2 is required for targeting Aurora-A kinase to the spindle"
3092:
2954:"Human TPX2 is required for targeting Aurora-A kinase to the spindle"
2071:
1883:
1819:
1767:
1447:
17:
3618:
Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA (2002).
2070:
protein MOS, that are vital to the completion of meiosis in
Xenopus
3015:
6044:
5686:
5679:
5589:
5486:
5386:
5364:
5359:
5354:
5349:
5344:
5256:
5251:
5246:
5241:
5231:
5201:
5181:
5058:
5053:
5034:
5029:
5019:
4995:
4990:
4985:
4961:
4956:
4946:
4941:
4936:
4926:
4906:
4891:
4886:
4881:
4861:
4856:
4846:
4841:
4836:
4831:
4826:
4816:
4811:
4806:
4801:
4781:
4776:
4771:
4766:
4761:
4756:
4741:
4691:
4686:
4580:
4575:
4570:
4565:
4560:
4555:
4516:
4448:
4443:
4392:
4387:
4313:
4308:
4303:
4269:
4261:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
4063:
4048:
4043:
4038:
4033:
4028:
2201:
2189:
1895:
2354:
1988:-associated protein that stabilizes centrosomal microtubules and
1410:
1406:
5579:
5506:
5501:
5491:
5464:
5221:
5171:
5152:
5147:
5142:
5137:
5092:
5087:
5082:
5077:
5024:
4980:
4921:
4916:
4866:
4851:
4821:
4751:
4667:
4662:
4657:
4590:
4492:
4433:
4428:
4332:
4298:
4183:
4178:
4173:
4142:
4110:
4098:
4093:
4088:
4078:
4073:
3883:: AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP
2195:
2177:
2171:
2165:
2079:
2039:
1865:
1826:
528:
5813:
5737:
5113:
4004:
3957:
3746:
2821:
Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS (September 2002).
975:
5548:
4083:
4068:
3742:
2183:
2124:
3540:
Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002).
3583:
Gigoux V, L'Hoste S, Raynaud F, Camonis J, Garbay C (2002).
1366:
negative regulation of G2/M transition of mitotic cell cycle
2035:
the mid-body immediately before the completion of mitosis.
1944:
passenger protein and regulates chromosome segregation and
5809:
3263:
Walter AO, Seghezzi W, Korver W, Sheung J, Lees E (2000).
2405:
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV (2004).
2461:
Hannak E, Kirkham M, Hyman AA, Oegema K (December 2001).
1996:, the base structure from which centrosomal microtubules
3838:: STRUCTURE OF UNPHOSPHORYLATED D274N MUTANT OF AURORA-A
3300:"DNA cloning using in vitro site-specific recombination"
784:
2913:"TACC1-chTOG-Aurora A protein complex in breast cancer"
1336:
regulation of signal transduction by p53 class mediator
1959:
Aurora A localizes next to the centrosome late in the
1936:
Aurora A and Aurora B kinases play important roles in
1296:
anaphase-promoting complex-dependent catabolic process
6100:
3661:
Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS (2002).
949:
5996:
5960:
5929:
5898:
5847:
5751:
5649:
5632:
5615:
5598:
5569:
5429:
5329:
5270:
5161:
5127:
5067:
5043:
5004:
4970:
4676:
4647:
4623:
4604:
4525:
4501:
4462:
4418:
4401:
4377:
4341:
4322:
4288:
4259:
4192:
4158:
4018:
3384:Katayama H, Zhou H, Li Q, Tatsuka M, Sen S (2001).
1724:
1671:
1641:
1588:
1391:
regulation of G2/M transition of mitotic cell cycle
3928:: STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358
3913:: STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626
2243:
2241:
2239:
2222:
2220:
2218:
2062:Aurora A phosphorylation directs the cytoplasmic
1029:protein serine/threonine/tyrosine kinase activity
731:
630:
3868:: AURORA-2 T287D T288D COMPLEXED WITH PHA-680632
2872:"Aurora B -TACC1 protein complex in cytokinesis"
2578:
2576:
2574:
2572:
2570:
2568:
2566:
2564:
2562:
3210:Farruggio DC, Townsley FM, Ruderman JV (1999).
1316:positive regulation of mitotic nuclear division
27:Protein-coding gene in the species Homo sapiens
3793:: Crystal Structure of Aurora-A Protein Kinase
3212:"Cdc20 associates with the kinase aurora2/Aik"
2248:GRCm38: Ensembl release 89: ENSMUSG00000027496
2038:Intriguingly, abolishment of Aurora A through
5825:
4020:Non-specific serine/threonine protein kinases
3969:
3758:
2456:
2454:
2452:
2450:
2400:
1396:ubiquitin-dependent protein catabolic process
1321:spindle assembly involved in female meiosis I
8:
2398:
2396:
2394:
2392:
2390:
2388:
2386:
2384:
2382:
2380:
1832:Aurora A is a member of a family of mitotic
2227:GRCh38: Ensembl release 89: ENSG00000087586
2108:and Neuroendocrine Transdifferentiation of
5832:
5818:
5810:
5748:
5734:
5124:
5110:
4403:Goodpasture-antigen-binding protein kinase
4015:
4001:
3976:
3962:
3954:
3765:
3751:
3743:
1668:
1585:
1421:
991:
772:
671:
568:
74:
5116:Serine/threonine-specific protein kinases
4290:(isocitrate dehydrogenase (NADP+)) kinase
4007:Serine/threonine-specific protein kinases
3989:Serine/threonine-specific protein kinases
3686:
3643:
3600:
3565:
3522:
3479:
3444:
3401:
3366:
3323:
3298:Hartley JL, Temple GF, Brasch MA (2000).
3280:
3245:
3235:
3133:
2977:
2928:
2887:
2846:
2797:
2748:
2706:
2651:
2641:
2600:
2542:
2512:
2510:
2508:
2506:
2486:
2422:
2317:
916:fetal liver hematopoietic progenitor cell
5651:Receptor protein serine/threonine kinase
1864:were first identified in 1990 during a
1840:. Aurora A is activated by one or more
1246:negative regulation of apoptotic process
1236:positive regulation of oocyte maturation
1049:protein serine/threonine kinase activity
6107:
5634:Low-density-lipoprotein receptor kinase
3780:
2517:Ma C, Cummings C, Liu XJ (March 2003).
2214:
1251:negative regulation of protein binding
29:
4379:Fas-activated serine/threonine kinase
1331:microtubule cytoskeleton organization
1311:anterior/posterior axis specification
1276:G2/M transition of mitotic cell cycle
736:
697:
692:
635:
594:
589:
7:
5660:Bone morphogenetic protein receptors
3497:Meraldi P, Honda R, Nigg EA (2002).
2300:Sen S, Zhou H, White RA (May 1997).
1914:genomes, on the other hand, contain
1844:and its activity peaks during the
4194:Dephospho-(reductase kinase) kinase
1064:protein heterodimerization activity
4649:G-protein coupled receptor kinases
2156:Aurora A kinase has been shown to
1721:
1638:
1561:
1542:
1516:
1497:
1471:
1452:
1301:protein localization to centrosome
954:
872:
810:
789:
25:
4639:Beta adrenergic receptor kinase-2
4324:(tyrosine 3-monooxygenase) kinase
2772:Du J, Hannon GJ (December 2002).
2106:Epithelial–mesenchymal transition
1822:that in humans is encoded by the
1816:serine/threonine-protein kinase 6
6110:
5331:Mitogen-activated protein kinase
3933:
3918:
3903:
3888:
3873:
3858:
3843:
3828:
3813:
3798:
3783:
2066:translation of mRNA's, like the
1044:ubiquitin protein ligase binding
965:
958:
720:
713:
707:
684:
619:
612:
606:
581:
38:
5717:Anti-MĂĽllerian hormone receptor
5600:(acetyl-CoA carboxylase) kinase
5272:(RNA-polymerase)-subunit kinase
4634:Beta adrenergic receptor kinase
4625:Beta adrenergic receptor kinase
2535:10.1128/MCB.23.5.1703-1716.2003
2407:"Aurora A, meiosis and mitosis"
1918:only to Aurora A and Aurora B.
1226:regulation of protein stability
1145:perinuclear region of cytoplasm
5340:Extracellular signal-regulated
2144:, work by shutting off mutant
1886:contains three members of the
1852:transition in the cell cycle.
1266:regulation of centrosome cycle
1054:histone serine kinase activity
976:More reference expression data
938:More reference expression data
1:
5404:P38 mitogen-activated protein
4503:cGMP-dependent protein kinase
4464:cAMP-dependent protein kinase
4160:Pyruvate dehydrogenase kinase
4106:Ataxia telangiectasia mutated
3437:10.1128/MCB.22.3.874-885.2002
3154:Biochem. Biophys. Res. Commun
2424:10.1016/j.biolcel.2003.09.008
2112:cells in aggressive disease.
2074:. Prior to the first meiotic
1286:mitotic centrosome separation
1120:microtubule organizing center
705:
604:
6133:Genes on human chromosome 20
4203:AMP-activated protein kinase
3216:Proc. Natl. Acad. Sci. U.S.A
2140:, two anti cancer drugs for
1351:mitotic spindle organization
1281:meiotic spindle organization
1271:cell projection organization
1125:chromosome passenger complex
5118:(EC 2.7.11.21-EC 2.7.11.30)
3359:10.1093/embo-reports/kvd058
1291:protein autophosphorylation
1256:neuron projection extension
6164:
5045:Elongation factor 2 kinase
4009:(EC 2.7.11.1-EC 2.7.11.20)
3723:gene details page in the
2008:microtubules than normal.
1929:catalytic domains. Their
5988:Michaelis–Menten kinetics
5747:
5733:
5440:MAP kinase kinase kinases
5123:
5109:
4972:Myosin light-chain kinase
4678:Ca2+/calmodulin-dependent
4343:Myosin-heavy-chain kinase
4014:
4000:
3778:
3558:10.1042/0264-6021:3630195
2750:10.1016/j.ccr.2008.12.005
2743:(1). Elsevier BV: 67–78.
2283:"Mouse PubMed Reference:"
2265:"Human PubMed Reference:"
1890:family: Aurora kinase A,
1798:
1793:
1789:
1782:
1766:
1747:
1728:
1695:
1664:
1645:
1612:
1581:
1568:
1564:
1549:
1545:
1536:
1523:
1519:
1504:
1500:
1491:
1478:
1474:
1459:
1455:
1446:
1431:
1424:
1420:
1404:
1221:regulation of cytokinesis
994:
990:
973:
957:
948:
935:
884:
875:
822:
813:
783:
775:
771:
754:
741:
704:
683:
674:
670:
653:
640:
603:
580:
571:
567:
522:
519:
509:
502:
497:
82:
77:
60:
55:
50:
46:
37:
32:
5880:Diffusion-limited enzyme
5740:Dual-specificity kinases
3135:10.1074/jbc.272.21.13766
3081:Nat. Rev. Mol. Cell Biol
2068:MAP kinase kinase kinase
1834:serine/threonine kinases
1760:Chr 2: 172.2 – 172.21 Mb
1753:Chr 20: 56.37 – 56.39 Mb
1100:microtubule cytoskeleton
5163:Cyclin-dependent kinase
3237:10.1073/pnas.96.13.7306
2643:10.3389/fonc.2014.00370
1356:protein phosphorylation
1241:centrosome localization
1110:spindle pole centrosome
1059:protein kinase activity
3602:10.1074/jbc.C200121200
3515:10.1093/emboj/21.4.483
3481:10.1074/jbc.M108252200
3403:10.1074/jbc.M107540200
3282:10.1038/sj.onc.1203847
3166:10.1006/bbrc.1998.8250
2930:10.1038/sj.onc.1206972
2889:10.1038/sj.onc.1207593
2708:10.1074/jbc.M208461200
2602:10.1074/jbc.M306275200
2319:10.1038/sj.onc.1201065
2104:to be involved in the
1911:Caenorhabditis elegans
1039:protein kinase binding
5973:Eadie–Hofstee diagram
5906:Allosteric regulation
3636:10.1083/jcb.200204155
3183:Cytogenet. Cell Genet
2970:10.1083/jcb.200204155
2479:10.1083/jcb.200108051
2099:Clinical significance
597:Chromosome 20 (human)
5983:Lineweaver–Burk plot
5006:Phosphorylase kinase
3717:genome location and
3679:10.1093/emboj/cdf409
2839:10.1093/emboj/cdf409
1878:Aurora kinase family
1361:response to wounding
1341:spindle organization
1205:mitotic spindle pole
1009:transferase activity
738:2 H3|2 94.84 cM
699:Chromosome 2 (mouse)
78:List of PDB id codes
51:Available structures
3725:UCSC Genome Browser
3228:1999PNAS...96.7306F
2090:Protein translation
1135:spindle microtubule
908:seminiferous tubule
854:ganglionic eminence
5942:Enzyme superfamily
5875:Enzyme promiscuity
5617:Tropomyosin kinase
5571:Tau-protein kinase
2790:10.1093/nar/gkf678
1979:During mitosis, a
1838:cell proliferation
1526:ENSMUSG00000027496
1381:mitotic cell cycle
1371:liver regeneration
1214:Biological process
1073:Cellular component
1014:nucleotide binding
1002:Molecular function
6098:
6097:
5807:
5806:
5803:
5802:
5799:
5798:
5729:
5728:
5725:
5724:
5105:
5104:
5101:
5100:
4586:Protein kinase N1
4541:Protein kinase Cζ
3951:
3950:
3552:(Pt 1): 195–200.
3316:10.1101/gr.143000
3195:10.1159/000134721
3064:10.1021/jp909869g
2778:Nucleic Acids Res
1963:and early in the
1809:
1808:
1805:
1804:
1778:
1777:
1743:
1742:
1718:
1717:
1660:
1659:
1635:
1634:
1577:
1576:
1558:
1557:
1532:
1531:
1513:
1512:
1487:
1486:
1468:
1467:
1416:
1415:
986:
985:
982:
981:
944:
943:
931:
930:
869:
868:
767:
766:
666:
665:
561:AURKA - orthologs
493:
492:
489:
488:
61:Ortholog search:
16:(Redirected from
6155:
6115:
6114:
6106:
5978:Hanes–Woolf plot
5921:Enzyme activator
5916:Enzyme inhibitor
5890:Enzyme catalysis
5834:
5827:
5820:
5811:
5749:
5735:
5382:C-Jun N-terminal
5125:
5111:
4615:Rhodopsin kinase
4606:Rhodopsin kinase
4536:Protein kinase C
4527:Protein kinase C
4512:Protein kinase G
4473:Protein kinase A
4084:Protein kinase B
4016:
4002:
3978:
3971:
3964:
3955:
3937:
3922:
3907:
3892:
3877:
3862:
3847:
3832:
3817:
3802:
3787:
3767:
3760:
3753:
3744:
3700:
3690:
3657:
3647:
3614:
3604:
3579:
3569:
3536:
3526:
3493:
3483:
3474:(12): 10719–26.
3458:
3448:
3415:
3405:
3396:(49): 46219–24.
3380:
3370:
3337:
3327:
3294:
3284:
3259:
3249:
3239:
3206:
3177:
3147:
3137:
3128:(21): 13766–71.
3112:
3093:10.1038/35048096
3075:
3036:
3035:
2998:
2992:
2991:
2981:
2949:
2943:
2942:
2932:
2908:
2902:
2901:
2891:
2867:
2861:
2860:
2850:
2818:
2812:
2811:
2801:
2769:
2763:
2762:
2752:
2727:
2721:
2720:
2710:
2701:(50): 48714–23.
2686:
2680:
2679:
2672:
2666:
2665:
2655:
2645:
2621:
2615:
2614:
2604:
2595:(51): 51786–95.
2580:
2557:
2556:
2546:
2514:
2501:
2500:
2490:
2458:
2445:
2444:
2426:
2402:
2375:
2374:
2338:
2332:
2331:
2321:
2312:(18): 2195–200.
2297:
2291:
2290:
2279:
2273:
2272:
2261:
2255:
2245:
2234:
2224:
1842:phosphorylations
1791:
1790:
1762:
1755:
1738:
1722:
1713:
1669:
1665:RefSeq (protein)
1655:
1639:
1630:
1586:
1562:
1543:
1517:
1498:
1472:
1453:
1422:
1386:centrosome cycle
1085:germinal vesicle
992:
978:
969:
962:
955:
940:
888:secondary oocyte
880:
878:Top expressed in
873:
834:ventricular zone
830:secondary oocyte
818:
816:Top expressed in
811:
790:
773:
763:
750:
739:
724:
717:
711:
700:
688:
672:
662:
649:
638:
623:
616:
610:
599:
585:
569:
563:
514:
507:
484:
75:
69:
48:
47:
42:
30:
21:
6163:
6162:
6158:
6157:
6156:
6154:
6153:
6152:
6148:Cancer research
6123:
6122:
6121:
6109:
6101:
6099:
6094:
6006:Oxidoreductases
5992:
5968:Enzyme kinetics
5956:
5952:List of enzymes
5925:
5894:
5865:Catalytic triad
5843:
5838:
5808:
5795:
5743:
5721:
5645:
5628:
5611:
5594:
5565:
5425:
5325:
5296:P70-S6 Kinase 1
5266:
5157:
5119:
5097:
5063:
5039:
5000:
4966:
4672:
4643:
4619:
4600:
4521:
4497:
4458:
4414:
4397:
4373:
4367:Aurora C kinase
4362:Aurora B kinase
4357:Aurora A kinase
4337:
4318:
4284:
4255:
4188:
4154:
4010:
3996:
3982:
3952:
3947:
3944:
3938:
3929:
3923:
3914:
3908:
3899:
3893:
3884:
3878:
3869:
3863:
3854:
3848:
3839:
3833:
3824:
3818:
3809:
3803:
3794:
3788:
3774:
3771:
3708:
3703:
3660:
3617:
3595:(26): 23742–6.
3582:
3539:
3496:
3461:
3425:Mol. Cell. Biol
3418:
3383:
3340:
3310:(11): 1788–95.
3297:
3275:(42): 4906–16.
3262:
3222:(13): 7306–11.
3209:
3180:
3150:
3115:
3078:
3048:
3044:
3042:Further reading
3039:
3000:
2999:
2995:
2951:
2950:
2946:
2923:(50): 8102–16.
2910:
2909:
2905:
2882:(26): 4516–22.
2869:
2868:
2864:
2820:
2819:
2815:
2784:(24): 5465–75.
2771:
2770:
2766:
2729:
2728:
2724:
2688:
2687:
2683:
2674:
2673:
2669:
2623:
2622:
2618:
2582:
2581:
2560:
2523:Mol. Cell. Biol
2516:
2515:
2504:
2460:
2459:
2448:
2404:
2403:
2378:
2340:
2339:
2335:
2299:
2298:
2294:
2281:
2280:
2276:
2263:
2262:
2258:
2246:
2237:
2225:
2216:
2212:
2207:
2154:
2110:Prostate Cancer
2101:
2092:
2064:polyadenylation
2060:
1981:mitotic spindle
1977:
1957:
1896:Aurora C kinase
1892:Aurora kinase B
1880:
1858:
1812:Aurora kinase A
1800:View/Edit Mouse
1795:View/Edit Human
1758:
1751:
1748:Location (UCSC)
1734:
1730:
1709:
1705:
1701:
1697:
1691:
1687:
1683:
1679:
1675:
1651:
1647:
1626:
1622:
1618:
1614:
1608:
1604:
1600:
1596:
1592:
1507:ENSG00000087586
1400:
1231:phosphorylation
1209:
1165:mitotic spindle
1140:spindle midzone
1105:meiotic spindle
1090:cell projection
1068:
1024:protein binding
1019:kinase activity
974:
964:
963:
936:
927:
922:
918:
914:
910:
906:
902:
898:
894:
890:
876:
865:
860:
856:
852:
848:
846:trabecular bone
844:
840:
836:
832:
828:
814:
758:
745:
737:
727:
726:
725:
718:
698:
675:Gene location (
657:
644:
636:
626:
625:
624:
617:
595:
572:Gene location (
523:
510:
503:
84:
62:
28:
23:
22:
15:
12:
11:
5:
6161:
6159:
6151:
6150:
6145:
6140:
6135:
6125:
6124:
6120:
6119:
6096:
6095:
6093:
6092:
6079:
6066:
6053:
6040:
6027:
6014:
6000:
5998:
5994:
5993:
5991:
5990:
5985:
5980:
5975:
5970:
5964:
5962:
5958:
5957:
5955:
5954:
5949:
5944:
5939:
5933:
5931:
5930:Classification
5927:
5926:
5924:
5923:
5918:
5913:
5908:
5902:
5900:
5896:
5895:
5893:
5892:
5887:
5882:
5877:
5872:
5867:
5862:
5857:
5851:
5849:
5845:
5844:
5839:
5837:
5836:
5829:
5822:
5814:
5805:
5804:
5801:
5800:
5797:
5796:
5794:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5757:
5755:
5745:
5744:
5738:
5731:
5730:
5727:
5726:
5723:
5722:
5720:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5683:
5682:
5677:
5672:
5667:
5656:
5654:
5653:(EC 2.7.11.30)
5647:
5646:
5644:
5643:
5639:
5637:
5636:(EC 2.7.11.29)
5630:
5629:
5627:
5626:
5622:
5620:
5619:(EC 2.7.11.28)
5613:
5612:
5610:
5609:
5605:
5603:
5602:(EC 2.7.11.27)
5596:
5595:
5593:
5592:
5587:
5582:
5576:
5574:
5573:(EC 2.7.11.26)
5567:
5566:
5564:
5563:
5558:
5553:
5552:
5551:
5546:
5541:
5536:
5531:
5526:
5521:
5511:
5510:
5509:
5504:
5499:
5494:
5484:
5483:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5436:
5434:
5433:(EC 2.7.11.25)
5427:
5426:
5424:
5423:
5422:
5421:
5416:
5411:
5401:
5400:
5399:
5394:
5389:
5379:
5378:
5377:
5372:
5367:
5362:
5357:
5352:
5347:
5336:
5334:
5333:(EC 2.7.11.24)
5327:
5326:
5324:
5323:
5318:
5313:
5308:
5303:
5298:
5293:
5288:
5283:
5277:
5275:
5274:(EC 2.7.11.23)
5268:
5267:
5265:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5168:
5166:
5165:(EC 2.7.11.22)
5159:
5158:
5156:
5155:
5150:
5145:
5140:
5134:
5132:
5131:(EC 2.7.11.21)
5121:
5120:
5114:
5107:
5106:
5103:
5102:
5099:
5098:
5096:
5095:
5090:
5085:
5080:
5074:
5072:
5071:(EC 2.7.11.21)
5065:
5064:
5062:
5061:
5056:
5050:
5048:
5047:(EC 2.7.11.20)
5041:
5040:
5038:
5037:
5032:
5027:
5022:
5017:
5011:
5009:
5008:(EC 2.7.11.19)
5002:
5001:
4999:
4998:
4993:
4988:
4983:
4977:
4975:
4974:(EC 2.7.11.18)
4968:
4967:
4965:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4704:
4699:
4694:
4689:
4683:
4681:
4680:(EC 2.7.11.17)
4674:
4673:
4671:
4670:
4665:
4660:
4654:
4652:
4651:(EC 2.7.11.16)
4645:
4644:
4642:
4641:
4636:
4630:
4628:
4627:(EC 2.7.11.15)
4621:
4620:
4618:
4617:
4611:
4609:
4608:(EC 2.7.11.14)
4602:
4601:
4599:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4532:
4530:
4529:(EC 2.7.11.13)
4523:
4522:
4520:
4519:
4514:
4508:
4506:
4505:(EC 2.7.11.12)
4499:
4498:
4496:
4495:
4490:
4485:
4480:
4475:
4469:
4467:
4466:(EC 2.7.11.11)
4460:
4459:
4457:
4456:
4451:
4446:
4441:
4436:
4431:
4425:
4423:
4422:(EC 2.7.11.10)
4416:
4415:
4413:
4412:
4408:
4406:
4399:
4398:
4396:
4395:
4390:
4384:
4382:
4375:
4374:
4372:
4371:
4370:
4369:
4364:
4359:
4348:
4346:
4339:
4338:
4336:
4335:
4329:
4327:
4320:
4319:
4317:
4316:
4311:
4306:
4301:
4295:
4293:
4286:
4285:
4283:
4282:
4277:
4272:
4266:
4264:
4257:
4256:
4254:
4253:
4252:
4251:
4246:
4241:
4233:
4232:
4231:
4226:
4218:
4217:
4216:
4211:
4199:
4197:
4190:
4189:
4187:
4186:
4181:
4176:
4171:
4165:
4163:
4156:
4155:
4153:
4152:
4151:
4150:
4140:
4139:
4138:
4133:
4128:
4123:
4113:
4108:
4103:
4102:
4101:
4096:
4091:
4081:
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4025:
4023:
4012:
4011:
4005:
3998:
3997:
3983:
3981:
3980:
3973:
3966:
3958:
3949:
3948:
3946:
3945:
3939:
3932:
3930:
3924:
3917:
3915:
3909:
3902:
3900:
3894:
3887:
3885:
3879:
3872:
3870:
3864:
3857:
3855:
3849:
3842:
3840:
3834:
3827:
3825:
3819:
3812:
3810:
3804:
3797:
3795:
3789:
3782:
3779:
3776:
3775:
3772:
3770:
3769:
3762:
3755:
3747:
3741:
3740:
3734:
3728:
3707:
3706:External links
3704:
3702:
3701:
3673:(17): 4491–9.
3658:
3615:
3580:
3537:
3494:
3459:
3416:
3381:
3338:
3295:
3260:
3207:
3189:(3–4): 201–3.
3178:
3148:
3113:
3076:
3058:(3): 1486–97.
3045:
3043:
3040:
3038:
3037:
3016:10.1038/ng1220
2993:
2944:
2903:
2862:
2833:(17): 4491–9.
2813:
2764:
2722:
2681:
2667:
2616:
2558:
2529:(5): 1703–16.
2502:
2473:(7): 1109–16.
2446:
2376:
2333:
2292:
2274:
2256:
2235:
2213:
2211:
2208:
2206:
2205:
2199:
2193:
2187:
2181:
2175:
2169:
2162:
2153:
2150:
2100:
2097:
2091:
2088:
2059:
2056:
1976:
1973:
1956:
1953:
1879:
1876:
1862:aurora kinases
1857:
1854:
1814:also known as
1807:
1806:
1803:
1802:
1797:
1787:
1786:
1780:
1779:
1776:
1775:
1773:
1771:
1764:
1763:
1756:
1749:
1745:
1744:
1741:
1740:
1726:
1725:
1719:
1716:
1715:
1693:
1692:
1666:
1662:
1661:
1658:
1657:
1643:
1642:
1636:
1633:
1632:
1610:
1609:
1583:
1579:
1578:
1575:
1574:
1566:
1565:
1559:
1556:
1555:
1547:
1546:
1540:
1534:
1533:
1530:
1529:
1521:
1520:
1514:
1511:
1510:
1502:
1501:
1495:
1489:
1488:
1485:
1484:
1476:
1475:
1469:
1466:
1465:
1457:
1456:
1450:
1444:
1443:
1438:
1433:
1429:
1428:
1418:
1417:
1414:
1413:
1402:
1401:
1399:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1217:
1215:
1211:
1210:
1208:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1076:
1074:
1070:
1069:
1067:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1005:
1003:
999:
998:
988:
987:
984:
983:
980:
979:
971:
970:
952:
946:
945:
942:
941:
933:
932:
929:
928:
926:
925:
924:primary oocyte
921:
917:
913:
909:
905:
901:
897:
893:
889:
885:
882:
881:
870:
867:
866:
864:
863:
859:
858:amniotic fluid
855:
851:
847:
843:
839:
835:
831:
827:
823:
820:
819:
807:
806:
798:
787:
781:
780:
777:RNA expression
769:
768:
765:
764:
756:
752:
751:
743:
740:
735:
729:
728:
719:
712:
706:
702:
701:
696:
690:
689:
681:
680:
668:
667:
664:
663:
655:
651:
650:
642:
639:
634:
628:
627:
618:
611:
605:
601:
600:
593:
587:
586:
578:
577:
565:
564:
521:
517:
516:
508:
500:
499:
495:
494:
491:
490:
487:
486:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6160:
6149:
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6130:
6128:
6118:
6113:
6108:
6104:
6090:
6086:
6085:
6080:
6077:
6073:
6072:
6067:
6064:
6060:
6059:
6054:
6051:
6047:
6046:
6041:
6038:
6034:
6033:
6028:
6025:
6021:
6020:
6015:
6012:
6008:
6007:
6002:
6001:
5999:
5995:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5965:
5963:
5959:
5953:
5950:
5948:
5947:Enzyme family
5945:
5943:
5940:
5938:
5935:
5934:
5932:
5928:
5922:
5919:
5917:
5914:
5912:
5911:Cooperativity
5909:
5907:
5904:
5903:
5901:
5897:
5891:
5888:
5886:
5883:
5881:
5878:
5876:
5873:
5871:
5870:Oxyanion hole
5868:
5866:
5863:
5861:
5858:
5856:
5853:
5852:
5850:
5846:
5842:
5835:
5830:
5828:
5823:
5821:
5816:
5815:
5812:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5758:
5756:
5754:
5750:
5746:
5741:
5736:
5732:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5662:
5661:
5658:
5657:
5655:
5652:
5648:
5641:
5640:
5638:
5635:
5631:
5624:
5623:
5621:
5618:
5614:
5607:
5606:
5604:
5601:
5597:
5591:
5588:
5586:
5583:
5581:
5578:
5577:
5575:
5572:
5568:
5562:
5559:
5557:
5554:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5516:
5515:
5512:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5489:
5488:
5485:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5442:
5441:
5438:
5437:
5435:
5432:
5428:
5420:
5417:
5415:
5412:
5410:
5407:
5406:
5405:
5402:
5398:
5395:
5393:
5390:
5388:
5385:
5384:
5383:
5380:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5342:
5341:
5338:
5337:
5335:
5332:
5328:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5278:
5276:
5273:
5269:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5169:
5167:
5164:
5160:
5154:
5151:
5149:
5146:
5144:
5141:
5139:
5136:
5135:
5133:
5130:
5126:
5122:
5117:
5112:
5108:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5075:
5073:
5070:
5066:
5060:
5057:
5055:
5052:
5051:
5049:
5046:
5042:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5012:
5010:
5007:
5003:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4978:
4976:
4973:
4969:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4684:
4682:
4679:
4675:
4669:
4666:
4664:
4661:
4659:
4656:
4655:
4653:
4650:
4646:
4640:
4637:
4635:
4632:
4631:
4629:
4626:
4622:
4616:
4613:
4612:
4610:
4607:
4603:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4533:
4531:
4528:
4524:
4518:
4515:
4513:
4510:
4509:
4507:
4504:
4500:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4470:
4468:
4465:
4461:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4426:
4424:
4421:
4417:
4410:
4409:
4407:
4405:(EC 2.7.11.9)
4404:
4400:
4394:
4391:
4389:
4386:
4385:
4383:
4381:(EC 2.7.11.8)
4380:
4376:
4368:
4365:
4363:
4360:
4358:
4355:
4354:
4353:
4352:Aurora kinase
4350:
4349:
4347:
4345:(EC 2.7.11.7)
4344:
4340:
4334:
4331:
4330:
4328:
4326:(EC 2.7.11.6)
4325:
4321:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4296:
4294:
4292:(EC 2.7.11.5)
4291:
4287:
4281:
4278:
4276:
4273:
4271:
4268:
4267:
4265:
4263:(EC 2.7.11.4)
4262:
4258:
4250:
4247:
4245:
4242:
4240:
4237:
4236:
4234:
4230:
4227:
4225:
4222:
4221:
4219:
4215:
4212:
4210:
4207:
4206:
4204:
4201:
4200:
4198:
4196:(EC 2.7.11.3)
4195:
4191:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4166:
4164:
4162:(EC 2.7.11.2)
4161:
4157:
4149:
4146:
4145:
4144:
4141:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4118:
4117:
4116:EIF-2 kinases
4114:
4112:
4109:
4107:
4104:
4100:
4097:
4095:
4092:
4090:
4087:
4086:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4026:
4024:
4022:(EC 2.7.11.1)
4021:
4017:
4013:
4008:
4003:
3999:
3994:
3990:
3986:
3979:
3974:
3972:
3967:
3965:
3960:
3959:
3956:
3942:
3936:
3931:
3927:
3921:
3916:
3912:
3906:
3901:
3897:
3891:
3886:
3882:
3876:
3871:
3867:
3861:
3856:
3852:
3846:
3841:
3837:
3831:
3826:
3822:
3816:
3811:
3807:
3801:
3796:
3792:
3786:
3781:
3777:
3768:
3763:
3761:
3756:
3754:
3749:
3748:
3745:
3738:
3735:
3732:
3729:
3726:
3722:
3721:
3716:
3715:
3710:
3709:
3705:
3698:
3694:
3689:
3684:
3680:
3676:
3672:
3668:
3664:
3659:
3655:
3651:
3646:
3641:
3637:
3633:
3630:(4): 617–23.
3629:
3625:
3621:
3616:
3612:
3608:
3603:
3598:
3594:
3590:
3589:J. Biol. Chem
3586:
3581:
3577:
3573:
3568:
3563:
3559:
3555:
3551:
3547:
3543:
3538:
3534:
3530:
3525:
3520:
3516:
3512:
3509:(4): 483–92.
3508:
3504:
3500:
3495:
3491:
3487:
3482:
3477:
3473:
3469:
3468:J. Biol. Chem
3465:
3460:
3456:
3452:
3447:
3442:
3438:
3434:
3431:(3): 874–85.
3430:
3426:
3422:
3417:
3413:
3409:
3404:
3399:
3395:
3391:
3390:J. Biol. Chem
3387:
3382:
3378:
3374:
3369:
3364:
3360:
3356:
3353:(3): 287–92.
3352:
3348:
3344:
3339:
3335:
3331:
3326:
3321:
3317:
3313:
3309:
3305:
3301:
3296:
3292:
3288:
3283:
3278:
3274:
3270:
3266:
3261:
3257:
3253:
3248:
3243:
3238:
3233:
3229:
3225:
3221:
3217:
3213:
3208:
3204:
3200:
3196:
3192:
3188:
3184:
3179:
3175:
3171:
3167:
3163:
3160:(1): 285–92.
3159:
3155:
3149:
3145:
3141:
3136:
3131:
3127:
3123:
3122:J. Biol. Chem
3119:
3114:
3110:
3106:
3102:
3098:
3094:
3090:
3086:
3082:
3077:
3073:
3069:
3065:
3061:
3057:
3053:
3052:J Phys Chem B
3047:
3046:
3041:
3033:
3029:
3025:
3021:
3017:
3013:
3010:(4): 403–12.
3009:
3005:
2997:
2994:
2989:
2985:
2980:
2975:
2971:
2967:
2964:(4): 617–23.
2963:
2959:
2955:
2948:
2945:
2940:
2936:
2931:
2926:
2922:
2918:
2914:
2907:
2904:
2899:
2895:
2890:
2885:
2881:
2877:
2873:
2866:
2863:
2858:
2854:
2849:
2844:
2840:
2836:
2832:
2828:
2824:
2817:
2814:
2809:
2805:
2800:
2795:
2791:
2787:
2783:
2779:
2775:
2768:
2765:
2760:
2756:
2751:
2746:
2742:
2738:
2734:
2726:
2723:
2718:
2714:
2709:
2704:
2700:
2696:
2695:J. Biol. Chem
2692:
2685:
2682:
2677:
2671:
2668:
2663:
2659:
2654:
2649:
2644:
2639:
2635:
2631:
2627:
2620:
2617:
2612:
2608:
2603:
2598:
2594:
2590:
2589:J. Biol. Chem
2586:
2579:
2577:
2575:
2573:
2571:
2569:
2567:
2565:
2563:
2559:
2554:
2550:
2545:
2540:
2536:
2532:
2528:
2524:
2520:
2513:
2511:
2509:
2507:
2503:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2455:
2453:
2451:
2447:
2442:
2438:
2434:
2430:
2425:
2420:
2417:(3): 215–29.
2416:
2412:
2408:
2401:
2399:
2397:
2395:
2393:
2391:
2389:
2387:
2385:
2383:
2381:
2377:
2372:
2368:
2364:
2360:
2356:
2352:
2349:(2): 189–93.
2348:
2344:
2337:
2334:
2329:
2325:
2320:
2315:
2311:
2307:
2303:
2296:
2293:
2288:
2284:
2278:
2275:
2270:
2266:
2260:
2257:
2253:
2249:
2244:
2242:
2240:
2236:
2232:
2228:
2223:
2221:
2219:
2215:
2209:
2203:
2200:
2197:
2194:
2191:
2188:
2185:
2182:
2179:
2176:
2173:
2170:
2167:
2164:
2163:
2161:
2159:
2151:
2149:
2147:
2143:
2139:
2135:
2131:
2128:
2126:
2122:
2118:
2113:
2111:
2107:
2098:
2096:
2089:
2087:
2083:
2081:
2077:
2073:
2069:
2065:
2057:
2055:
2053:
2049:
2045:
2041:
2036:
2033:
2029:
2024:
2022:
2017:
2015:
2009:
2007:
2003:
1999:
1995:
1991:
1987:
1982:
1974:
1972:
1970:
1966:
1962:
1954:
1952:
1949:
1947:
1943:
1939:
1934:
1932:
1928:
1924:
1919:
1917:
1913:
1912:
1907:
1906:
1901:
1897:
1893:
1889:
1888:aurora kinase
1885:
1877:
1875:
1873:
1872:
1867:
1863:
1855:
1853:
1851:
1847:
1843:
1839:
1835:
1830:
1828:
1825:
1821:
1817:
1813:
1801:
1796:
1792:
1788:
1785:
1781:
1774:
1772:
1769:
1765:
1761:
1757:
1754:
1750:
1746:
1739:
1737:
1733:
1727:
1723:
1720:
1714:
1712:
1708:
1704:
1700:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1667:
1663:
1656:
1654:
1650:
1644:
1640:
1637:
1631:
1629:
1625:
1621:
1617:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1584:
1582:RefSeq (mRNA)
1580:
1573:
1572:
1567:
1563:
1560:
1554:
1553:
1548:
1544:
1541:
1539:
1535:
1528:
1527:
1522:
1518:
1515:
1509:
1508:
1503:
1499:
1496:
1494:
1490:
1483:
1482:
1477:
1473:
1470:
1464:
1463:
1458:
1454:
1451:
1449:
1445:
1442:
1439:
1437:
1434:
1430:
1427:
1423:
1419:
1412:
1408:
1403:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1261:cell division
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1218:
1216:
1213:
1212:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1077:
1075:
1072:
1071:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1006:
1004:
1001:
1000:
997:
996:Gene ontology
993:
989:
977:
972:
968:
961:
956:
953:
951:
947:
939:
934:
923:
919:
915:
911:
907:
903:
899:
895:
891:
887:
886:
883:
879:
874:
871:
861:
857:
853:
849:
845:
841:
837:
833:
829:
825:
824:
821:
817:
812:
809:
808:
805:
803:
799:
797:
796:
792:
791:
788:
786:
782:
778:
774:
770:
762:
757:
753:
749:
744:
734:
730:
723:
716:
710:
703:
695:
691:
687:
682:
678:
673:
669:
661:
656:
652:
648:
643:
633:
629:
622:
615:
609:
602:
598:
592:
588:
584:
579:
575:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
518:
513:
506:
501:
496:
485:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
6084:Translocases
6081:
6068:
6055:
6042:
6029:
6019:Transferases
6016:
6003:
5860:Binding site
5291:P70S6 kinase
3940:
3925:
3910:
3895:
3880:
3865:
3850:
3835:
3820:
3805:
3790:
3719:
3713:
3670:
3666:
3627:
3624:J. Cell Biol
3623:
3592:
3588:
3549:
3545:
3506:
3502:
3471:
3467:
3428:
3424:
3393:
3389:
3350:
3346:
3307:
3303:
3272:
3268:
3219:
3215:
3186:
3182:
3157:
3153:
3125:
3121:
3087:(1): 21–32.
3084:
3080:
3055:
3051:
3007:
3003:
2996:
2961:
2958:J. Cell Biol
2957:
2947:
2920:
2916:
2906:
2879:
2875:
2865:
2830:
2826:
2816:
2781:
2777:
2767:
2740:
2736:
2725:
2698:
2694:
2684:
2670:
2633:
2629:
2619:
2592:
2588:
2526:
2522:
2470:
2467:J. Cell Biol
2466:
2414:
2410:
2355:10.1038/2496
2346:
2342:
2336:
2309:
2305:
2295:
2286:
2277:
2268:
2259:
2155:
2152:Interactions
2132:
2129:
2114:
2102:
2093:
2084:
2061:
2051:
2047:
2043:
2037:
2025:
2021:prometaphase
2018:
2013:
2010:
1978:
1958:
1955:Localization
1950:
1935:
1920:
1909:
1903:
1899:
1881:
1869:
1859:
1831:
1823:
1815:
1811:
1810:
1732:NP_001278114
1729:
1696:
1681:NP_001310234
1677:NP_001310233
1673:NP_001310232
1653:NM_001291185
1646:
1628:NM_001323305
1624:NM_001323304
1620:NM_001323303
1613:
1569:
1550:
1524:
1505:
1479:
1460:
1440:
1435:
1170:cytoskeleton
1150:axon hillock
1095:spindle pole
912:otic placode
900:otic vesicle
800:
793:
759:172,212,455
746:172,198,110
520:External IDs
83:
5855:Active site
5742:(EC 2.7.12)
5129:Polo kinase
5069:Polo kinase
3773:PDB gallery
2737:Cancer Cell
2630:Front Oncol
2142:lung cancer
2138:rociletinib
2134:Osimertinib
2117:cytokinesis
2028:cytokinesis
1986:microtubule
1946:cytokinesis
1916:orthologues
1190:nucleoplasm
1180:microtubule
1034:ATP binding
658:56,392,337
645:56,369,389
498:Identifiers
6138:Cell cycle
6127:Categories
6058:Isomerases
6032:Hydrolases
5899:Regulation
4420:IÎşB kinase
3995:2.7.11-12)
3546:Biochem. J
3304:Genome Res
3004:Nat. Genet
2411:Biol. Cell
2343:Nat. Genet
2254:, May 2017
2233:, May 2017
2210:References
2052:Drosophila
2044:C. elegans
1998:polymerize
1994:Îł-tubulins
1942:chromosome
1931:N-terminal
1927:C-terminal
1923:centrosome
1905:Drosophila
1882:The human
1868:screen of
1306:cell cycle
1185:centrosome
1155:pronucleus
804:(ortholog)
541:HomoloGene
6143:EC 2.7.11
5937:EC number
4546:PKC alpha
3109:205011994
2759:1535-6108
2121:aneuploid
2076:metaphase
2032:centriole
1969:telophase
1856:Discovery
1736:NP_035627
1711:NP_940839
1707:NP_940838
1703:NP_940837
1699:NP_940836
1689:NP_940835
1685:NP_003591
1649:NM_011497
1616:NM_198437
1606:NM_198436
1602:NM_198435
1598:NM_198434
1594:NM_198433
1590:NM_003600
1426:Orthologs
1160:centriole
1080:cytoplasm
549:GeneCards
5961:Kinetics
5885:Cofactor
5848:Activity
4902:KIAA0999
4797:MAPKAPK5
4792:MAPKAPK3
4787:MAPKAPK2
3697:12198151
3654:12177045
3611:11976319
3576:11903063
3533:11847097
3490:11790771
3455:11784863
3412:11551964
3377:11256614
3347:EMBO Rep
3334:11076863
3291:11039908
3269:Oncogene
3256:10377410
3101:11413462
3072:20047310
3032:29442841
3024:12881723
2988:12177045
2939:14603251
2917:Oncogene
2898:15064709
2876:Oncogene
2857:12198151
2808:12490715
2717:12354758
2662:25566507
2611:14523000
2553:12588989
2497:11748251
2441:29416056
2433:15182704
2371:40012197
2306:Oncogene
2250:–
2229:–
2158:interact
2002:anaphase
1961:G1 phase
1846:G2 phase
1784:Wikidata
1405:Sources:
920:epiblast
862:testicle
6117:Biology
6071:Ligases
5841:Enzymes
5561:MAP3K14
5539:MAP3K11
5534:MAP3K10
5524:MAP3K13
5519:MAP3K12
5321:RPS6KC1
5316:RPS6KA1
5311:RPS6KA3
5306:RPS6KA2
5301:RPS6KB2
5286:RPS6KA4
5281:RPS6KA5
4932:Kalirin
4897:SNF1LK2
4136:EIF2AK4
4131:EIF2AK3
3985:Kinases
3737:PDBe-KB
3731:PDBe-KB
3645:2174010
3567:1222467
3368:1083732
3224:Bibcode
3203:9605851
3174:9514916
3144:9153231
2979:2174010
2653:4274903
2636:: 370.
2488:2199344
2363:9771714
2328:9174055
2252:Ensembl
2231:Ensembl
2072:Oocytes
2058:Meiosis
2048:Xenopus
1990:Kinesin
1975:Mitosis
1965:S phase
1938:mitosis
1900:Xenopus
1871:Xenopus
1850:M phase
1538:UniProt
1493:Ensembl
1432:Species
1411:QuickGO
1376:meiosis
1200:cytosol
1195:spindle
1175:nucleus
1130:midbody
779:pattern
637:20q13.2
505:Aliases
6103:Portal
6045:Lyases
5791:MAP2K7
5786:MAP2K6
5781:MAP2K5
5776:MAP2K4
5771:MAP2K3
5766:MAP2K2
5761:MAP2K1
5712:ACVRL1
5707:ACVR2B
5702:ACVR2A
5697:ACVR1C
5692:ACVR1B
5675:BMPR1B
5670:BMPR1A
5544:MAP3K7
5529:MAP3K9
5480:MAP3K8
5475:MAP3K7
5470:MAP3K6
5465:MAP3K5
5460:MAP3K4
5455:MAP3K3
5450:MAP3K2
5445:MAP3K1
5419:MAPK14
5414:MAPK13
5409:MAPK11
5397:MAPK10
5375:MAPK15
5370:MAPK12
5262:CDC2L1
5237:CDC2L5
4912:SNF1LK
4737:CAMK2G
4732:CAMK2D
4727:CAMK2B
4722:CAMK2A
4712:CAMK1G
4707:CAMK1D
4702:CAMK1B
4697:CAMK1A
4551:PRKCB1
4488:PRKACA
4483:PRKACB
4478:PRKACG
4454:IKBKAP
4280:BCKDHB
4275:BCKDHA
4249:PRKAG3
4244:PRKAG2
4239:PRKAG1
4229:PRKAB2
4224:PRKAB1
4214:PRKAA2
4209:PRKAA1
4054:STK38L
3711:Human
3695:
3688:126178
3685:
3667:EMBO J
3652:
3642:
3609:
3574:
3564:
3531:
3524:125866
3521:
3503:EMBO J
3488:
3453:
3446:133550
3443:
3410:
3375:
3365:
3332:
3325:310948
3322:
3289:
3254:
3244:
3201:
3172:
3142:
3107:
3099:
3070:
3030:
3022:
2986:
2976:
2937:
2896:
2855:
2848:126178
2845:
2827:EMBO J
2806:
2799:140054
2796:
2757:
2715:
2660:
2650:
2609:
2551:
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1770:search
1768:PubMed
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950:BioGPS
904:morula
896:morula
892:zygote
850:embryo
826:oocyte
537:894678
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5753:MAP2K
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4882:PRKD2
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4832:MKNK2
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4807:MARK2
4802:MARK1
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