57:
399:; it would have been the first and only such designation by a state legislature in the nation, however the legislation was not adopted by the Senate. The legislation was introduced in November 2009 as Assembly Bill 556 by Representatives Hebl, Vruwink, Williams, Pasch, Danou, and Fields; it was cosponsored by Senator Taylor. The bill passed the Assembly on May 15, 2010, and was dropped by the Senate on April 28.
44:
1989:
Benbouziane B, Ribelles P, Aubry C, Martin R, Kharrat P, Riazi A, Langella P, Bermudez-Humaran LG (2013). "Development of a Stress-Inducible
Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces".
629:. After transport, IL-10 may directly downregulate inflammation. In principle, this method may be useful for intestinal delivery of other protein therapeutics that are unstable or difficult to produce in large quantities and an alternative to the systemic treatment of IBD.
312:
is mainly isolated from either the dairy environment, or plant material. Dairy isolates are suggested to have evolved from plant isolates through a process in which genes without benefit in the rich milk were lost or downregulated. This process, called genome erosion or
799:Åkerberg C, Hofvendahl K, Zacchi G, Hahn-Hägerdal B (1998). "Modelling the influence of pH, temperature, glucose and lactic acid concentrations on the kinetics of lactic acid production by Lactococcus lactis ssp. Lactis ATCC 19435 in whole-wheat flour".
929:
Facklam RR, Pigott NE, Collins MD. Identification of
Lactococcus species from human sources. Proceedings of the XI Lancefield International Symposium on Streptococci and Streptococcal Diseases, Siena, Italy. Stuttgart: Gustav Fischer Verlag;
321:. The proposed transition from the plant to the dairy environment was reproduced in the laboratory through experimental evolution of a plant isolate that was cultivated in milk for a prolonged period. Consistent with the results from
747:
Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, van
Deventer SJ, Neirynck S, Peppelenbosch MP, Steidler L (2006). "A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease".
414:
cause significant economic losses each year by preventing the bacteria from fully metabolizing the milk substrate. Several epidemiologic studies showed the phages mainly responsible for these losses are from the species
697:
NZ9000 can inhibit HT-29 proliferation and induce cell apoptosis by itself. The success of this strain's construction helped to inhibit migration and expansion of cancer cells, showing that the secretion properties of
449:
has been demonstrated to be a promising candidate for the delivery of functional proteins because of its noninvasive and nonpathogenic characteristics. Many different expression systems of
2905:
868:
Wessels S, Axelsson L, Bech Hansen E, De Vuyst L, Laulund S, Lähteenmäki L, Lindgren S, et al. (November 2004). "The lactic acid bacteria, the food chain, and their regulation".
621:
because of its bacterial size and shape, and the major part of the effect may be due to recombinant IL-10 production in situ in intestinal lymphoid tissue. Both routes may involve
693:
In addition, it was demonstrated that tumor growth can be inhibited by the LAB strain itself, due to the ability of LAB to produce exopolysaccharides. This study shows that
2248:
Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E (2000). "Treatment of Murine
Colitis by Lactococcus lactis Secreting Interleukin-10".
2342:
Bauvois B (2012). "New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression".
2879:
940:
Mannion PT, Rothburn MM (November 1990). "Diagnosis of bacterial endocarditis caused by
Streptococcus lactis and assisted by immunoblotting of serum antibodies".
2918:
846:
1215:"Diversity analysis of dairy and nondairy Lactococcus lactis isolates, using a novel multilocus sequence analysis scheme and (GTG)5-PCR fingerprinting"
2293:"Recombinant Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT-29 cells"
2961:
2853:
2647:
Looijesteijn PJ, Trapet L, de Vries E, Abee T, Hugenholtz J (2001). "Physiological function of exopolysaccharides produced by
Lactococcus lactis".
2892:
290:. The byproduct of ATP energy production is lactic acid. The lactic acid produced by the bacterium curdles the milk, which then separates to form
1504:"Transcriptome landscape of Lactococcus lactis reveals many novel RNAs including a small regulatory RNA involved in carbon uptake and metabolism"
2027:"A lactose fermentation product produced by Lactococcus lactis subsp. lactis, acetate, inhibits the motility of flagellated pathogenic bacteria"
975:
522:
motility through disruption of flagellar rotation rather than through irreversible damage to morphology and physiology. Lactose fermentation by
228:
cells are cocci that group in pairs and short chains, and, depending on growth conditions, appear ovoid with a typical length of 0.5 - 1.5
2576:
731:
244:). They have a homofermentative metabolism, meaning they produce lactic acid from sugars. They've also been reported to produce exclusive
2966:
2620:
Ruas-Madiedo P, Hugenholtz J, Zoon P (2002). "An overview of the functionality of exopolysaccharides produced by lactic acid bacteria".
782:
Roissart, H. and Luquet F.M. Bactéries lactiques: aspects fondamentaux et technologiques. Uriage, Lorica, France, 1994, vol. 1, p. 605.
1066:
van
Hylckama Vlieg JE, Rademaker, JL, Bachmann H, Molenaar D, Kelly WJ, Siezen RJ (2006). "Natural diversity and adaptive responses of
833:
787:
505:
as the experimental group, the research team found that a product of lactose fermentation is the cause of motility impairment in
306:
is one of the best characterized low GC Gram positive bacteria with detailed knowledge on genetics, metabolism and biodiversity.
2971:
158:
224:, but has also become famous as the first genetically modified organism to be used alive for the treatment of human disease.
2897:
682:
binding to the MMP-9 promoter and thus downregulating MMP-9 expression. This, in turn, reduces the survival rate, inhibits
1604:
Coffey A, Ross RP (2002). "Bacteriophage-resistance systems in dairy starter strains: molecular analysis to application".
256:-(−)-lactic acid can be produced when cultured at low pH. The capability to produce lactic acid is one of the reasons why
2559:
Hirayama K, Rafter J (1999). "The role of lactic acid bacteria in colon cancer prevention: Mechanistic considerations".
2125:"Change in intracellular pH of Escherichia coli mediates the chemotactic response to certain attractants and repellents"
1889:
Mierau I, Kleerebezem M (2005). "10 years of the nisin-controlled gene expression system (NICE) in
Lactococcus lactis".
395:, also the number one cheese-producing state in the United States, voted in 2010 to name this bacterium as the official
265:
2172:
Stordeur P, Goldman M (1998). "Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects".
560:
1934:"Improved stress tolerance of GroESL-overproducing Lactococcus lactis and probiotic Lactobacillus paracasei NFBC 338"
56:
2956:
2923:
659:
571:
294:
that are used to produce cheese. Other uses that have been reported for this bacterium include the production of
593:
The authors propose two possible routes by which IL-10 can reach its therapeutic target. Genetically engineered
647:
NZ9000 was demonstrated to be a cell factory for the secretion of biologically active KiSS1 protein, exerting
260:
is one of the most important microorganisms in the dairy industry. Based on its history in food fermentation,
1154:
Passerini D, Beltramo C, Coddeville M, Quentin Y, Ritzenthaler P, Daveran-Mingot ML, Le
Bourgeois P (2010).
454:
2792:
2754:
622:
283:
2209:"Suppression of T cell-mediated injury in human gut by interleukin 10: role of matrix metalloproteinases"
1213:
Rademaker JL, Herbet H, Starrenburg MJ, Naser SM, Gevers D, Kelly WJ, Hugenholtz J, et al. (2007).
583:
141:
1331:
Bolotin A, Quinquis B, Renault P, Sorokin A, Ehrlich SD, Kulakauskas S, Lapidus A, et al. (2004).
329:
losing or downregulating genes that are dispensable in milk and the upregulation of peptide transport.
2933:
2827:
2257:
1945:
1745:
1403:
1287:
1226:
1167:
983:
442:
322:
318:
98:
1838:
Varma NR, Toosa H, Foo HL, Alitheen NB, Nor
Shamsudin M, Arbab AS, Yusoff K, Abdul Rahim R (2013).
1386:
van de Guchte M, Penaud S, Grimaldi C, Barbe V, Bryson K, Nicolas P, Robert C, et al. (2006).
587:
538:, which in turn slows the rotation of their flagella. These results highlight the potential use of
314:
2735:
1840:"Display of the viral epitopes on Lactococcus lactis: a model for food grade vaccine against EV71"
1675:
2684:"Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer"
2594:
2056:
1914:
1791:"Lactic acid bacteria—20 years exploring their potential as live vectors for mucosal vaccination"
1629:
816:
368:
295:
51:
274:
is of crucial importance for manufacturing dairy products, such as buttermilk and cheeses. When
2884:
2814:
2715:
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2007:
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1541:
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1368:
1313:
1270:
Siezen RJ, Starrenburg MJ, Boekhorst J, Renckens B, Molenaar D, van Hylckama Vlieg JE (2008).
1252:
1195:
1136:
1087:
1045:
957:
912:
783:
765:
727:
380:
1561:"Transfer of Streptococcus lactis and Related Streptococci to the Genus Lactococcus gen. nov"
2705:
2695:
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2629:
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1999:
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1079:
1035:
949:
904:
877:
808:
757:
531:
108:
2606:
998:
895:
Aguirre M, Collins MD (August 1993). "Lactic acid bacteria and human clinical infection".
639:
strain that maintains a plasmid containing a tumor metastasis-inhibiting peptide known as
602:
457:
2261:
1949:
1749:
1407:
1291:
1230:
1171:
2710:
2683:
2501:
2476:
2452:
2427:
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1815:
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1503:
1479:
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1426:
1387:
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1332:
1308:
1271:
1247:
1214:
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1155:
1131:
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908:
618:
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564:
556:
372:
2660:
2633:
2225:
2208:
2149:
2124:
2100:
2075:
1966:
1933:
1866:
1839:
1766:
1729:
1579:
1107:"Chromosomal diversity in Lactococcus lactis and the origin of dairy starter cultures"
2950:
1957:
1757:
1449:
Bachmann H, Starrenburg MJ, Molenaar D, Kleerebezem M, van Hylckama Vlieg JE (2012).
953:
396:
210:
2140:
2091:
1918:
820:
2819:
1633:
671:
626:
567:
467:
430:
376:
2910:
2269:
2060:
2003:
1730:"Milk contamination and resistance to processing conditions determine the fate of
1519:
43:
2568:
1180:
1083:
1040:
1023:
2866:
2786:
2355:
648:
515:
476:
249:
118:
2394:
1559:
Schleifer KH, Kraus J, Dvorak C, Kilpper-Bälz R, Collins MD, Fischer W (1985).
1396:
Proceedings of the National Academy of Sciences of the United States of America
881:
2537:
2443:
2309:
2185:
1902:
1806:
1617:
761:
683:
667:
663:
606:
507:
501:
488:
341:
229:
217:
2777:
2700:
1587:
1527:
2840:
2477:"The KISS1 metastasis suppressor: mechanistic insights and clinical utility"
2076:"Cytoplasmic pH mediates pH taxis and weak-acid repellent taxis of bacteria"
1416:
1276:
isolates from plants identifies mechanisms of adaptation to the plant niche"
1156:"Genes but Not Genomes Reveal Bacterial Domestication of Lactococcus Lactis"
497:
392:
388:
363:) is used in the early stages for the production of many cheeses, including
333:
268:(GRAS) status, with few case reports of it being an opportunistic pathogen.
237:
213:
78:
2719:
2668:
2586:
2510:
2461:
2412:
2363:
2328:
2277:
2052:
2011:
1975:
1910:
1824:
1775:
1625:
1545:
1488:
1435:
1372:
1317:
1256:
1199:
1140:
1091:
1049:
769:
445:(LAB) as functional protein delivery vectors has been widely investigated.
17:
2545:
2234:
2193:
2158:
2109:
1875:
1856:
1470:
1333:"Complete sequence and comparative genome analysis of the dairy bacterium
961:
916:
812:
282:
is added to milk, the bacterium uses enzymes to produce energy molecules (
2771:
2043:
2026:
1299:
1238:
1122:
687:
553:
384:
298:, beer or wine, some breads, and other fermented foodstuffs like soymilk
241:
68:
2858:
2806:
2801:
703:
679:
575:
527:
287:
88:
2871:
1789:
Wyszyńska A, Kobierecka P, Bardowski J, Jagusztyn-Krynicka EK (2015).
582:
requires much lower doses than systemic treatments like antibodies to
492:
strains were severely disrupted by lactose utilization on the part of
340:. One of them, LLnc147, was shown to be involved in carbon uptake and
2379:"Matrix metalloproteinases: regulators of the tumor microenvironment"
598:
482:
221:
2748:
1353:
2845:
640:
633:
Tumor-suppressor through Tumor metastasis-inhibiting peptide KISS1
407:
299:
2492:
2832:
417:
364:
291:
2752:
474:
can hinder motility in pathogenic bacteria, the motilities of
2524:
Gorbach SL (1990). "Lactic acid bacteria and human health".
678:
activates the MAPK pathway via GPR54 signaling, suppressing
2561:
Lactic Acid Bacteria: Genetics, Metabolism and Applications
2428:"Physiology and pathophysiology of matrix metalloproteases"
1022:
Kok J, Buist G, Zomer AL, van Hijum SA, Kuipers OP (2005).
2682:
Ji K, Ye L, Ruge F, Hargest R, Mason MD, Jiang WG (2014).
706:
may serve as a new tool for cancer therapy in the future.
574:. A study by Lothar Steidler and Wolfgang Hans shows that
2291:
Zhang B, Li A, Zuo F, Yu R, Zeng Z, Ma H, Chen S (2016).
605:, and the protein may diffuse to responsive cells in the
542:
for preventing infections by multiple bacterial species.
666:, and regulation of the signaling pathways controlling
2761:
1932:Desmond C, Fitzgerald G, Stanton C, Ross R (2004).
1024:"Comparative and functional genomics of lactococci"
658:strain effectively downregulated the expression of
1392:reveals extensive and ongoing reductive evolution"
336:were identified by Meulen et al. in the genome of
1272:"Genome-scale genotype-phenotype matching of two
674:. The reason for this is that KiSS1 expressed in
651:effects on human colorectal cancer HT-29 cells.
1699:
1697:
999:"History of Fermented Soymilk and Its Products"
1599:
1597:
670:growth, survival, invasion, inflammation, and
578:synthesis of IL-10 by genetically engineered
8:
1455:can be reproduced by experimental evolution"
847:"History of the GRAS List and SCOGS Reviews"
466:In one study that sought to prove that some
2749:
2649:International Journal of Food Microbiology
1061:
1059:
406:in dairy factories is not without issues.
42:
31:
2709:
2699:
2500:
2451:
2402:
2318:
2308:
2224:
2148:
2099:
2042:
1965:
1865:
1855:
1814:
1765:
1728:Madera C, Monjardin C, Suarez JE (2004).
1535:
1478:
1425:
1415:
1362:
1352:
1307:
1246:
1189:
1179:
1130:
1039:
635:Another study, led by Zhang B, created a
563:(IBD), since IL-10 has a central role in
325:(see references above), this resulted in
2025:Nakamura S, Morimoto YV, Kudo S (2015).
1502:Meulen SB, Jong Ad, Kok J (2016-03-03).
662:(MMP-9), a crucial key in the invasion,
2377:Kessenbrock K, Plaks V, Werb Z (2010).
1451:"Microbial domestication signatures of
976:"Bacteria Genomes - LACTOCOCCUS LACTIS"
870:Trends in Food Science & Technology
714:
2744:- the Bacterial Diversity Metadatabase
2602:
2592:
1280:Applied and Environmental Microbiology
1219:Applied and Environmental Microbiology
801:Applied Microbiology and Biotechnology
722:Madigan MT, Martinko JM, eds. (2005).
317:, has been described in several other
216:used extensively in the production of
7:
2934:dac9a7df-614b-4d31-a835-b693fb75708d
1844:Biotechnology Research International
1590:– via Elsevier Science Direct.
1105:Kelly WJ, Ward LJ, Leahy SC (2010).
1568:Systematic and Applied Microbiology
2563:. Vol. 76. pp. 391–394.
909:10.1111/j.1365-2672.1993.tb02753.x
25:
1388:"The complete genome sequence of
834:Integr8 – Species search results:
453:have been developed and used for
1958:10.1128/AEM.70.10.5929-5936.2004
1758:10.1128/AEM.70.12.7365-7371.2004
1676:"No State Microbe For Wisconsin"
1072:Current Opinion in Biotechnology
726:(11th ed.). Prentice Hall.
654:KiSS1 secreted from recombinant
625:mechanisms that are enhanced in
55:
2962:Bacteria used in dairy products
2207:Pender SL, et al. (1998).
2141:10.1128/JB.145.3.1196-1208.1981
2092:10.1128/JB.145.3.1209-1221.1981
897:Journal of Applied Bacteriology
724:Brock Biology of Microorganisms
997:Shurtleff W, Aoyagi A (2004).
192:L. l. lactis bv. diacetylactis
1:
2661:10.1016/S0168-1605(00)00437-2
2634:10.1016/S0958-6946(01)00160-1
2270:10.1126/science.289.5483.1352
2226:10.1016/S0016-5085(98)70136-2
2004:10.1016/j.jbiotec.2013.04.019
1580:10.1016/S0723-2020(85)80052-7
1520:10.1080/15476286.2016.1146855
559:(IL-10) for the treatment of
2569:10.1007/978-94-017-2027-4_25
2426:Klein T, Bischoff R (2011).
2123:Repaske DR, Adler J (1981).
2074:Kihara M, Macnab RM (1981).
1181:10.1371/journal.pone.0015306
1111:Genome Biology and Evolution
1084:10.1016/j.copbio.2006.02.007
1041:10.1016/j.femsre.2005.04.004
954:10.1016/0163-4453(90)94149-T
266:generally recognized as safe
2356:10.1016/j.bbcan.2011.10.001
561:inflammatory bowel diseases
546:Secretion of Interleukin-10
511:. It is suggested that the
2988:
2967:Bacteria described in 1873
2475:Nash KT, Welch DR (2006).
2395:10.1016/j.cell.2010.03.015
1734:bacteriophages in dairies"
1649:"And Now, a State Microbe"
1647:Davey M (April 15, 2010).
1335:Streptococcus thermophilus
882:10.1016/j.tifs.2004.03.003
750:Clin Gastroenterol Hepatol
302:, buttermilk, and others.
2538:10.3109/07853899009147239
2444:10.1007/s00726-010-0689-x
2310:10.1186/s12934-016-0506-7
2186:10.3109/08830189809043006
1903:10.1007/s00253-005-0107-6
1891:Appl Microbiol Biotechnol
1807:10.1007/s00253-015-6498-0
1795:Appl Microbiol Biotechnol
1028:FEMS Microbiology Reviews
762:10.1016/j.cgh.2006.03.028
660:Matrix metalloproteinases
613:. Another route involves
572:matrix metalloproteinases
441:The feasibility of using
236:does not produce spores (
177:
172:
147:
140:
52:Scientific classification
50:
41:
34:
2701:10.1186/1471-2407-14-723
2297:Microbial Cell Factories
1709:docs.legis.wisconsin.gov
1705:"2009 Assembly Bill 556"
1390:Lactobacillus bulgaricus
391:. The state Assembly of
2481:Frontiers in Bioscience
1682:. National Public Radio
1618:10.1023/A:1020639717181
1606:Antonie van Leeuwenhoek
1417:10.1073/pnas.0603024103
548:Genetically engineered
2972:Gram-positive bacteria
1938:Appl Environ Microbiol
1738:Appl Environ Microbiol
623:paracellular transport
240:) and are not motile (
1471:10.1101/gr.121285.111
1003:www.soyinfocenter.com
813:10.1007/s002530051232
584:tumor necrosis factor
429:(all from the family
2344:Biochim Biophys Acta
2044:10.1099/mic.0.000031
1341:Nature Biotechnology
1300:10.1128/AEM.01850-07
1239:10.1128/AEM.01017-07
980:2Can Karyn's Genomes
464:Lactose fermentation
443:lactic acid bacteria
437:Therapeutic benefits
361:Streptococcus lactis
323:comparative genomics
319:lactic acid bacteria
252:. However, reported
27:Species of bacterium
2262:2000Sci...289.1352S
2256:(5483): 1352–1355.
1950:2004ApEnM..70.5929D
1857:10.1155/2013/431315
1750:2004ApEnM..70.7365M
1408:2006PNAS..103.9274V
1292:2008ApEnM..74..424S
1231:2007ApEnM..73.7128R
1172:2010PLoSO...515306P
702:of this particular
315:reductive evolution
2911:lactococcus-lactis
2793:Lactococcus lactis
2763:Lactococcus lactis
2738:Lactococcus lactis
2526:Annals of Medicine
1732:Lactococcus lactis
1453:Lactococcus lactis
1274:Lactococcus lactis
1123:10.1093/gbe/evq056
1068:Lactococcus lactis
617:being taken up by
458:protein expression
447:Lactococcus lactis
332:Hundreds of novel
296:pickled vegetables
272:Lactococcus lactis
206:Lactococcus lactis
151:Lactococcus lactis
36:Lactococcus lactis
2944:
2943:
2755:Taxon identifiers
2578:978-90-481-5312-1
2174:Int. Rev. Immunol
1944:(10): 5929–5936.
1850:(11): 4032–4036.
733:978-0-13-144329-7
690:of cancer cells.
530:that reduces the
348:Cheese production
255:
247:
202:
201:
16:(Redirected from
2979:
2957:Streptococcaceae
2937:
2936:
2927:
2926:
2914:
2913:
2901:
2900:
2888:
2887:
2875:
2874:
2862:
2861:
2849:
2848:
2836:
2835:
2823:
2822:
2810:
2809:
2797:
2796:
2795:
2782:
2781:
2780:
2750:
2724:
2723:
2713:
2703:
2679:
2673:
2672:
2644:
2638:
2637:
2628:(2–3): 163–171.
2617:
2611:
2610:
2604:
2600:
2598:
2590:
2556:
2550:
2549:
2521:
2515:
2514:
2504:
2472:
2466:
2465:
2455:
2423:
2417:
2416:
2406:
2374:
2368:
2367:
2339:
2333:
2332:
2322:
2312:
2288:
2282:
2281:
2245:
2239:
2238:
2228:
2213:Gastroenterology
2204:
2198:
2197:
2180:(5–6): 501–522.
2169:
2163:
2162:
2152:
2135:(3): 1196–1208.
2120:
2114:
2113:
2103:
2086:(3): 1209–1221.
2071:
2065:
2064:
2046:
2022:
2016:
2015:
1986:
1980:
1979:
1969:
1929:
1923:
1922:
1886:
1880:
1879:
1869:
1859:
1835:
1829:
1828:
1818:
1801:(7): 2967–2977.
1786:
1780:
1779:
1769:
1725:
1719:
1718:
1716:
1715:
1701:
1692:
1691:
1689:
1687:
1672:
1666:
1665:
1663:
1661:
1644:
1638:
1637:
1601:
1592:
1591:
1565:
1556:
1550:
1549:
1539:
1499:
1493:
1492:
1482:
1446:
1440:
1439:
1429:
1419:
1383:
1377:
1376:
1366:
1356:
1328:
1322:
1321:
1311:
1267:
1261:
1260:
1250:
1210:
1204:
1203:
1193:
1183:
1151:
1145:
1144:
1134:
1102:
1096:
1095:
1063:
1054:
1053:
1043:
1019:
1013:
1012:
1010:
1009:
994:
988:
987:
982:. Archived from
972:
966:
965:
937:
931:
927:
921:
920:
892:
886:
885:
865:
859:
858:
856:
854:
842:
836:
831:
825:
824:
796:
790:
780:
774:
773:
744:
738:
737:
719:
552:can secrete the
532:intracellular pH
338:L. lactis MG1363
253:
245:
153:
109:Streptococcaceae
60:
59:
46:
32:
21:
2987:
2986:
2982:
2981:
2980:
2978:
2977:
2976:
2947:
2946:
2945:
2940:
2932:
2930:
2922:
2917:
2909:
2904:
2896:
2891:
2883:
2878:
2870:
2865:
2857:
2852:
2844:
2839:
2831:
2826:
2818:
2813:
2805:
2800:
2791:
2790:
2785:
2776:
2775:
2770:
2757:
2736:Type strain of
2732:
2727:
2681:
2680:
2676:
2646:
2645:
2641:
2619:
2618:
2614:
2601:
2591:
2579:
2558:
2557:
2553:
2523:
2522:
2518:
2474:
2473:
2469:
2425:
2424:
2420:
2376:
2375:
2371:
2341:
2340:
2336:
2290:
2289:
2285:
2247:
2246:
2242:
2206:
2205:
2201:
2171:
2170:
2166:
2122:
2121:
2117:
2073:
2072:
2068:
2024:
2023:
2019:
1988:
1987:
1983:
1931:
1930:
1926:
1888:
1887:
1883:
1837:
1836:
1832:
1788:
1787:
1783:
1744:(12): 7365–71.
1727:
1726:
1722:
1713:
1711:
1703:
1702:
1695:
1685:
1683:
1674:
1673:
1669:
1659:
1657:
1646:
1645:
1641:
1612:(1–4): 303–21.
1603:
1602:
1595:
1563:
1558:
1557:
1553:
1501:
1500:
1496:
1459:Genome Research
1448:
1447:
1443:
1385:
1384:
1380:
1354:10.1038/nbt1034
1330:
1329:
1325:
1269:
1268:
1264:
1225:(22): 7128–37.
1212:
1211:
1207:
1153:
1152:
1148:
1104:
1103:
1099:
1065:
1064:
1057:
1021:
1020:
1016:
1007:
1005:
996:
995:
991:
974:
973:
969:
939:
938:
934:
928:
924:
894:
893:
889:
876:(10): 498–505.
867:
866:
862:
852:
850:
844:
843:
839:
832:
828:
798:
797:
793:
781:
777:
746:
745:
741:
734:
721:
720:
716:
712:
518:mainly affects
439:
350:
194:
190:
186:
182:
168:
162:
155:
149:
136:
99:Lactobacillales
54:
28:
23:
22:
15:
12:
11:
5:
2985:
2983:
2975:
2974:
2969:
2964:
2959:
2949:
2948:
2942:
2941:
2939:
2938:
2928:
2915:
2902:
2889:
2876:
2863:
2850:
2837:
2824:
2811:
2798:
2783:
2767:
2765:
2759:
2758:
2753:
2747:
2746:
2731:
2730:External links
2728:
2726:
2725:
2674:
2655:(1–2): 71–80.
2639:
2612:
2603:|journal=
2577:
2551:
2516:
2467:
2438:(2): 271–290.
2418:
2369:
2334:
2283:
2240:
2219:(3): 573–583.
2199:
2164:
2115:
2066:
2037:(4): 701–707.
2017:
1998:(2): 120–129.
1981:
1924:
1897:(6): 705–717.
1881:
1830:
1781:
1720:
1693:
1667:
1654:New York Times
1639:
1593:
1574:(2): 183–195.
1551:
1514:(3): 353–366.
1494:
1441:
1402:(24): 9274–9.
1378:
1347:(12): 1554–8.
1323:
1262:
1205:
1166:(12): e15306.
1146:
1097:
1055:
1014:
989:
986:on 2008-01-12.
967:
932:
922:
887:
860:
837:
826:
807:(6): 682–690.
791:
775:
756:(6): 754–759.
739:
732:
713:
711:
708:
686:, and induces
611:lamina propria
565:downregulating
557:interleukin-10
438:
435:
408:Bacteriophages
349:
346:
238:nonsporulating
200:
199:
184:L. l. hordniae
180:L. l. cremoris
175:
174:
170:
169:
156:
145:
144:
138:
137:
133:L. lactis
130:
128:
124:
123:
116:
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106:
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101:
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6:
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2:
2984:
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2968:
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2955:
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2935:
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2925:
2920:
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2903:
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2829:
2825:
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2803:
2799:
2794:
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2784:
2779:
2773:
2769:
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2764:
2760:
2756:
2751:
2745:
2743:
2739:
2734:
2733:
2729:
2721:
2717:
2712:
2707:
2702:
2697:
2693:
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2678:
2675:
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2658:
2654:
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2640:
2635:
2631:
2627:
2623:
2616:
2613:
2608:
2596:
2588:
2584:
2580:
2574:
2570:
2566:
2562:
2555:
2552:
2547:
2543:
2539:
2535:
2531:
2527:
2520:
2517:
2512:
2508:
2503:
2498:
2494:
2490:
2486:
2482:
2478:
2471:
2468:
2463:
2459:
2454:
2449:
2445:
2441:
2437:
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2429:
2422:
2419:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2373:
2370:
2365:
2361:
2357:
2353:
2349:
2345:
2338:
2335:
2330:
2326:
2321:
2316:
2311:
2306:
2302:
2298:
2294:
2287:
2284:
2279:
2275:
2271:
2267:
2263:
2259:
2255:
2251:
2244:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2203:
2200:
2195:
2191:
2187:
2183:
2179:
2175:
2168:
2165:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2130:
2126:
2119:
2116:
2111:
2107:
2102:
2097:
2093:
2089:
2085:
2081:
2077:
2070:
2067:
2062:
2058:
2054:
2050:
2045:
2040:
2036:
2032:
2028:
2021:
2018:
2013:
2009:
2005:
2001:
1997:
1993:
1992:J. Biotechnol
1985:
1982:
1977:
1973:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1928:
1925:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1892:
1885:
1882:
1877:
1873:
1868:
1863:
1858:
1853:
1849:
1845:
1841:
1834:
1831:
1826:
1822:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1785:
1782:
1777:
1773:
1768:
1763:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1733:
1724:
1721:
1710:
1706:
1700:
1698:
1694:
1681:
1677:
1671:
1668:
1656:
1655:
1650:
1643:
1640:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1600:
1598:
1594:
1589:
1585:
1581:
1577:
1573:
1569:
1562:
1555:
1552:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1498:
1495:
1490:
1486:
1481:
1476:
1472:
1468:
1465:(1): 115–24.
1464:
1460:
1456:
1454:
1445:
1442:
1437:
1433:
1428:
1423:
1418:
1413:
1409:
1405:
1401:
1397:
1393:
1391:
1382:
1379:
1374:
1370:
1365:
1360:
1355:
1350:
1346:
1342:
1338:
1336:
1327:
1324:
1319:
1315:
1310:
1305:
1301:
1297:
1293:
1289:
1286:(2): 424–36.
1285:
1281:
1277:
1275:
1266:
1263:
1258:
1254:
1249:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1216:
1209:
1206:
1201:
1197:
1192:
1187:
1182:
1177:
1173:
1169:
1165:
1161:
1157:
1150:
1147:
1142:
1138:
1133:
1128:
1124:
1120:
1116:
1112:
1108:
1101:
1098:
1093:
1089:
1085:
1081:
1078:(2): 183–90.
1077:
1073:
1069:
1062:
1060:
1056:
1051:
1047:
1042:
1037:
1034:(3): 411–33.
1033:
1029:
1025:
1018:
1015:
1004:
1000:
993:
990:
985:
981:
977:
971:
968:
963:
959:
955:
951:
947:
943:
936:
933:
926:
923:
918:
914:
910:
906:
903:(2): 95–107.
902:
898:
891:
888:
883:
879:
875:
871:
864:
861:
848:
841:
838:
835:
830:
827:
822:
818:
814:
810:
806:
802:
795:
792:
789:
788:2-9507477-0-1
785:
779:
776:
771:
767:
763:
759:
755:
751:
743:
740:
735:
729:
725:
718:
715:
709:
707:
705:
701:
696:
691:
689:
685:
681:
677:
673:
669:
665:
661:
657:
652:
650:
646:
642:
638:
634:
630:
628:
624:
620:
616:
612:
608:
604:
601:IL-10 in the
600:
596:
591:
589:
585:
581:
577:
573:
570:cascades and
569:
566:
562:
558:
555:
551:
547:
543:
541:
537:
533:
529:
525:
521:
517:
514:
510:
509:
504:
503:
499:
495:
491:
490:
485:
484:
479:
478:
473:
469:
465:
461:
459:
456:
452:
448:
444:
436:
434:
432:
428:
424:
420:
419:
413:
409:
405:
400:
398:
397:state microbe
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
347:
345:
343:
339:
335:
330:
328:
324:
320:
316:
311:
307:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
267:
263:
259:
251:
243:
239:
235:
231:
227:
223:
219:
215:
212:
211:gram-positive
208:
207:
198:
197:
196:L. l. tructae
193:
189:
185:
181:
176:
171:
166:
160:
154:
152:
146:
143:
142:Binomial name
139:
135:
134:
129:
126:
125:
122:
121:
117:
114:
113:
110:
107:
104:
103:
100:
97:
94:
93:
90:
87:
84:
83:
80:
77:
74:
73:
70:
67:
64:
63:
58:
53:
49:
45:
40:
37:
33:
30:
19:
2762:
2741:
2737:
2691:
2687:
2677:
2652:
2648:
2642:
2625:
2621:
2615:
2560:
2554:
2532:(1): 37–41.
2529:
2525:
2519:
2493:10.2741/1824
2484:
2480:
2470:
2435:
2431:
2421:
2389:(1): 52–67.
2386:
2382:
2372:
2350:(1): 29–36.
2347:
2343:
2337:
2300:
2296:
2286:
2253:
2249:
2243:
2216:
2212:
2202:
2177:
2173:
2167:
2132:
2128:
2118:
2083:
2079:
2069:
2034:
2031:Microbiology
2030:
2020:
1995:
1991:
1984:
1941:
1937:
1927:
1894:
1890:
1884:
1847:
1843:
1833:
1798:
1794:
1784:
1741:
1737:
1731:
1723:
1712:. Retrieved
1708:
1684:. Retrieved
1679:
1670:
1658:. Retrieved
1652:
1642:
1609:
1605:
1571:
1567:
1554:
1511:
1507:
1497:
1462:
1458:
1452:
1444:
1399:
1395:
1389:
1381:
1344:
1340:
1334:
1326:
1283:
1279:
1273:
1265:
1222:
1218:
1208:
1163:
1159:
1149:
1114:
1110:
1100:
1075:
1071:
1067:
1031:
1027:
1017:
1006:. Retrieved
1002:
992:
984:the original
979:
970:
948:(3): 317–8.
945:
941:
935:
925:
900:
896:
890:
873:
869:
863:
851:. Retrieved
840:
829:
804:
800:
794:
778:
753:
749:
742:
723:
717:
699:
694:
692:
675:
672:angiogenesis
655:
653:
644:
636:
632:
631:
627:inflammation
614:
597:may produce
594:
592:
579:
568:inflammatory
549:
545:
544:
539:
535:
523:
519:
512:
506:
500:
493:
487:
481:
475:
471:
470:produced by
468:fermentation
463:
462:
455:heterologous
450:
446:
440:
431:Siphoviridae
426:
422:
416:
411:
410:specific to
403:
401:
360:
356:
352:
351:
337:
331:
326:
309:
308:
303:
279:
275:
271:
270:
261:
257:
233:
225:
205:
204:
203:
195:
191:
188:L. l. lactis
187:
183:
179:
178:
164:
150:
148:
132:
131:
119:
35:
29:
2867:iNaturalist
2787:Wikispecies
2622:Int Dairy J
2487:: 647–659.
2432:Amino Acids
2129:J Bacteriol
2080:J Bacteriol
1508:RNA Biology
588:recombinant
516:supernatant
477:Pseudomonas
402:The use of
250:lactic acid
173:Subspecies
120:Lactococcus
18:ActoBiotics
2951:Categories
2688:BMC Cancer
2303:(1): 102.
1714:2017-11-29
1686:28 October
1117:: 729–44.
1008:2024-01-14
710:References
684:metastasis
668:tumor cell
664:metastasis
649:inhibition
607:epithelium
536:Salmonella
520:Salmonella
508:Salmonella
502:Salmonella
489:Leptospira
359:(formerly
342:metabolism
334:small RNAs
218:buttermilk
163:Schleifer
2605:ignored (
2595:cite book
1660:April 19,
1588:0723-2020
1528:1547-6286
942:J. Infect
700:L. lactis
695:L. lactis
676:L. lactis
656:L. lactis
645:L. lactis
637:L. lactis
615:L. lactis
595:L. lactis
586:(TNF) or
580:L. lactis
550:L. lactis
540:L. lactis
526:produces
524:L. lactis
513:L. lactis
498:flagellar
494:L. lactis
472:L. lactis
451:L. lactis
412:L. lactis
404:L. lactis
393:Wisconsin
389:Roquefort
369:camembert
353:L. lactis
327:L. lactis
310:L. lactis
304:L. lactis
276:L. lactis
262:L. lactis
258:L. lactis
242:nonmotile
234:L. lactis
226:L. lactis
214:bacterium
127:Species:
79:Bacillota
2885:10599288
2772:Wikidata
2720:25260785
2669:11252513
2587:10532395
2511:16146758
2462:20640864
2413:20371345
2364:22020293
2329:27287327
2278:10958782
2053:25573770
2012:23664884
1976:15466535
1919:24151938
1911:16088349
1825:25750046
1776:15574937
1626:12369198
1546:26950529
1489:22080491
1436:16754859
1373:15543133
1318:18039825
1257:17890345
1200:21179431
1160:PLOS ONE
1141:20847124
1092:16517150
1050:15936843
930:1990:127
821:46383610
770:16716759
688:dormancy
554:cytokine
496:. Using
385:Parmesan
286:), from
105:Family:
75:Phylum:
69:Bacteria
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