335:
360:
402:
349:
414:
31:
678:
vegetables and fruits are significantly protective against SCC risk. On the other hand, consumption of whole milk, yogurt, and cheese may increase SCC risk in susceptible people. In addition, meat and fat dietary pattern can increase the risk of SCC in people without a history of SCC, but the association is again more prominent in people with a history of skin cancer. Tobacco smoking and a dietary pattern characterized by high beer and liquor intake also increase the risk of SCC significantly.
108:
659:
647:
635:
623:
426:
198:
450:, which are flat cells that line many areas of the body. Some of which are keratinocytes. Accumulation of these cancer cells causes a microscopic focus of abnormal cells that are, at least initially, locally confined within the specific tissue in which the progenitor cell resided. This condition is called squamous-cell
401:
677:
Studies have found evidences for an association between diet and skin cancers, including SCC. The consumption of high-fat dairy foods increases SCC tumor risk in people with previous skin cancer. Green leafy vegetables may help prevent development of subsequent SCC and multiple studies found that raw
1450:
Sinha S, Su S, Workentine M, Agabalyan N, Cheng M, Gabriel V, Biernaskie J (January 2017). "Transcriptional
Analysis Reveals Evidence of Chronically Impeded ECM Turnover and Epithelium-to-Mesenchyme Transition in Scar Tissue Giving Rise to Marjolin's Ulcer".
441:
Cancer can be considered a very large and exceptionally heterogeneous family of malignant diseases, with squamous-cell carcinomas comprising one of the largest subsets. All SCC lesions are thought to begin via the repeated, uncontrolled division of cancer
479:
363:
Cytopathology of squamous-cell carcinoma, nonkeratinizing variant, with typical features. Pap stain. Yet, these findings are overall less specific than for keratinizing squamous-cell carcinoma, and most can be seen in other cancers such as
1575:
Chen YK, Lee CH, Wu IC, Liu JS, Wu DC, Lee JM, Goan YG, Chou SH, Huang CT, Lee CY, Hung HC, Yang JF, Wu MT (July 2009). "Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in
Taiwanese men".
1693:
Bahmanyar S, Ye W (2006). "Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden".
461:
or other delimiting structure to invade adjacent tissues. Once the lesion has grown and progressed to the point where it has breached, penetrated, and infiltrated adjacent structures, it is referred to as
600:
signet ring-cell squamous-cell carcinoma (occasionally rendered as signet ring-cell squamous-cell carcinoma) is a histological variant characterized by concentric rings composed of keratin and large
341:
of a highly differentiated squamous-cell carcinoma of the mouth. Typical squamous-cell carcinoma cells are large with abundant eosinophilic cytoplasm and large, often vesicular, nuclei.
395:
staining is the main histological marker for squamous-cell carcinoma. In addition, TP63 is an essential transcription factor to establish identity of the squamous cells.
413:
1155:
1119:
1080:
837:
Syed MI, Stewart M, Syed S, Dahill S, Adams C, McLellan DR, Clark LJ (January 2011). "Squamous cell carcinoma of the thyroid gland: primary or secondary disease?".
201:
Photograph of a squamous-cell carcinoma. The tumour is on the left, obstructing the bronchus (lung); beyond the tumour, the bronchus is inflamed and contains mucus.
522:
spindle-cell squamous-cell carcinoma (code 8074/3) It is also known as spindle-cell carcinoma, and is a subtype characterized by spindle-shaped atypical cells.
1324:
593:
clear-cell squamous-cell carcinoma (also known as clear-cell carcinoma of the skin) is characterized by keratinocytes that appear clear as a result of
425:
784:
145:
576:
adenoid squamous-cell carcinoma (also known as pseudoglandular squamous-cell carcinoma) is characterized by a tubular microscopic pattern and
1507:
1434:
1402:
1337:
942:
917:
587:
277:
323:
214:
192:
1526:
De
Stefani E, Deneo-Pellegrini H, Ronco AL, Boffetta P, Brennan P, Muñoz N, Castellsagué X, Correa P, Mendilaharsu M (October 2003).
1377:
359:
133:
96:
615:
toward the cell membrane, giving the cell a distinctive superficial resemblance to a "signet ring" when viewed under a microscope.
334:
1126:- Source image by Ravi Mehrotra, Anurag Gupta, Mamta Singh and Rahela Ibrahim (Creative Commons Attribution 2.0 Generic license.)
658:
466:" squamous-cell carcinoma. Once a carcinoma becomes invasive, it is able to spread to other organs and cause the formation of a
348:
292:
646:
229:
92:
634:
622:
280:
spreads slowly and usually stays near the vagina, but may spread to the lungs and liver. This is the most common type of
221:, but paraneoplastic syndrome is more commonly associated with small-cell lung cancer. It is primarily due to smoking.
498:
61:. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the
206:
73:
1613:"Food intake and risk of squamous cell carcinoma of the skin in a community: the Nambour skin cancer cohort study"
958:
912:(1st Canadian ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 660.
266:
232:(HPV), primarily HPV 16 and 18, are strongly implicated in the development of SCC of the penis. Three carcinomas
725:"Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China"
30:
586:
basaloid squamous-cell carcinoma is mostly found in or near the tongue, tonsils, or larynx, but may also occur
548:
246:
1343:
697:
210:
136:
is the second most common skin cancer, accounting for over 1 million cases in the United States each year.
605:
1368:
Van Holten, Valerie; World Health
Organization (1990). Muir, C.S.; Percy, C.L.; Van Holten, V. (eds.).
1137:
72:
The squamous-cell carcinomas of different body sites can show differences in their presented symptoms,
560:
or burn wound. More recent evidence, however, suggests that genetic differences exist between SCC and
483:
407:
SCC well-differentiated, left upper paraspinal back marked for biopsy with adjacent actinic keratosis
376:
122:
116:
1528:"Food groups and risk of squamous cell carcinoma of the oesophagus: a case-control study in Uruguay"
265:, squamous-cell carcinoma is very aggressive in nature. It is difficult to detect as no increase in
1752:
561:
557:
553:
125:(cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to SCC.
1040:
167:(EAC). SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach.
1719:
1476:
862:
463:
1170:
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, et al. (April 2020).
240:
107:
252:
Bowenoid papulosis, which histologically resembles Bowen disease, presents as reddish papules.
17:
1747:
1711:
1675:
1654:"Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study"
1634:
1593:
1557:
1503:
1468:
1430:
1398:
1373:
1333:
1305:
1254:
1203:
1149:
1113:
1074:
1021:
1003:
938:
913:
907:
854:
814:
746:
594:
458:
451:
160:
156:
62:
1495:
1703:
1665:
1624:
1585:
1547:
1539:
1460:
1295:
1285:
1244:
1234:
1193:
1183:
1011:
995:
846:
736:
81:
1742:
536:
380:
372:
312:
66:
1101:
1062:
326:
and corneal intraepithelial neoplasia comprise ocular surface squamous neoplasia (OSSN).
1136:
Authors: Caroline I.M. Underwood, M.D., Alexis Musick, B.S., Carolyn Glass, M.D., Ph.D.
1552:
1527:
1198:
1172:"Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells"
1171:
1016:
983:
880:
609:
388:
365:
300:
281:
164:
35:
1300:
1273:
1249:
1222:
205:
When associated with the lung, it is typically a centrally located large-cell cancer (
1736:
1652:
Ibiebele TI, van der Pols JC, Hughes MC, Marks GC, Williams GM, Green AC (May 2007).
999:
447:
352:
218:
176:
866:
1723:
1480:
612:
580:
577:
355:
of squamous-cell carcinoma, keratinizing variant, with typical features. Pap stain.
180:
148:
shows an aggressive biological phenotype resulting in poor prognosis for patients.
342:
1464:
269:
levels is seen, meaning that the cancer is often diagnosed at an advanced stage.
111:
A large head and neck squamous-cell carcinoma of the tongue as seen on CT imaging
172:
806:
243:
presents as leukoplakia on the shaft. Around a third of cases progress to SCC.
1707:
1589:
982:
Srivastava, Himsweta; Shree, Sneha; Guleria, Kiran; Singh, Usha R (May 2017).
850:
467:
443:
58:
1670:
1653:
1007:
764:
311:
Most bladder cancer is transitional cell, but bladder cancer associated with
1188:
569:
487:
168:
77:
1715:
1679:
1638:
1597:
1561:
1543:
1472:
1309:
1290:
1258:
1239:
1207:
1025:
858:
818:
750:
1223:"Tumor taxonomy for the developmental lineage classification of neoplasms"
785:"Types of head and neck cancer - Understanding - Macmillan Cancer Support"
1332:. World Health Organization Classification of Tumours. Lyon: IARC Press.
608:. These vacuoles grow to such an extent that they radically displace the
491:
262:
249:, a variation of Bowen's disease, presents as erythroplakia on the glans.
741:
724:
197:
1326:
Pathology and
Genetics of Tumours of the Lung, Pleura, Thymus and Heart
1124:
Last author update: 24 September 2020. Last staff update: 4 April 2022.
1085:
Last author update: 24 September 2020. Last staff update: 4 April 2022.
601:
1629:
1612:
1323:
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, eds. (2004).
384:
338:
54:
984:"Pure Primary Squamous Cell Carcinoma of Ovary – A Rare Case Report"
535:
Other variants of SCCs are recognized under other systems, such as
333:
196:
106:
29:
1372:(2nd ed.). Geneva, Switzerland: World Health Organization.
516:
large-cell nonkeratinizing squamous-cell carcinoma (code 8072/3)
457:, and it is diagnosed when the tumor has not yet penetrated the
392:
179:
may offer the possibility of a cure. If the disease has spread,
1611:
Hughes MC, van der Pols JC, Marks GC, Green AC (October 2006).
568:
One method of classifying squamous-cell carcinomas is by their
937:(8th ed.). Philadelphia: Saunders/Elsevier. p. 688.
1087:- Source image from National Cancer Institute (Public Domain)
525:
adenoid/pseudoglandular squamous-cell carcinoma (code 8075/3)
519:
small-cell keratinizing squamous-cell carcinoma (code 8073/3)
513:
large-cell keratinizing squamous-cell carcinoma (code 8071/3)
1370:
1039:
Dr
Nicholas Turnbull, A/Prof Patrick Emanual (2014-05-03).
1274:"Tumor classification: molecular analysis meets Aristotle"
446:
of epithelial lineage or characteristics. SCCs arise from
175:
are common initial symptoms. If the disease is localized,
765:"Recurrent Squamous Cell Carcinoma In Situ of the Finger"
1429:(6th ed.). New York, NY: McGraw-Hill. p. 743.
909:
Porth pathophysiology: concepts of altered health states
368:
as well (which, however, tends to have fine chromatin).
171:(difficulty swallowing, solids worse than liquids) and
480:
27:
Carcinoma that derives from squamous epithelial cells
528:
intraepidermal squamous-cell carcinoma (code 8081/3)
1102:"Cervix - Squamous cell carcinoma and variants"
1063:"Cervix - Squamous cell carcinoma and variants"
906:Pooler C, Hannon RA, Porth C, Matfin G (2010).
813:, Treasure Island (FL): StatPearls Publishing,
556:is a type of SCC that arises from a nonhealing
507:papillary squamous-cell carcinoma (code 8052/3)
504:verrucous squamous-cell carcinoma (code 8051/3)
933:Robbins S, Kumar V, Abbas A, Fausto N (2007).
299:(SOC) is a rare tumor that accounts for 1% of
1427:Fitzpatrick's dermatology in general medicine
805:Howell, Jesse Y.; Ramsey, Michael L. (2022),
383:may suggest a squamous-cell carcinoma, but a
8:
1154:: CS1 maint: multiple names: authors list (
1118:: CS1 maint: multiple names: authors list (
1079:: CS1 maint: multiple names: authors list (
692:
690:
1425:Fitzpatrick TB, Freedberg IM, eds. (2003).
1393:Rapini RP, Bolognia JL, Jorizzo JL (2007).
988:Journal of Clinical and Diagnostic Research
419:SCC, left lateral canthus marked for biopsy
53:, comprises a number of different types of
1658:The American Journal of Clinical Nutrition
177:surgical removal of the affected esophagus
1669:
1628:
1551:
1299:
1289:
1248:
1238:
1197:
1187:
1015:
740:
564:, which were previously underappreciated.
531:lymphoepithelial carcinoma (code 8082/3).
1420:
1418:
1416:
1414:
358:
347:
99:, lung, fingers, and anogenital region.
1502:. Rijeka, Croatia: InTech. p. 68.
959:"Squamous-cell Carcinoma of the Vagina"
723:Yu Y, Yang A, Hu S, Yan H (June 2009).
686:
618:
397:
236:are associated with SCCs of the penis:
1147:
1111:
1072:
839:The Journal of Laryngology and Otology
146:squamous-cell carcinoma of the thyroid
1521:
1519:
1096:- Image annotated by Mikael Häggström
1057:- Image annotated by Mikael Häggström
510:squamous-cell carcinoma (code 8070/3)
391:generally establishes the diagnosis.
278:Squamous cell carcinoma of the vagina
95:has been associated with SCCs of the
7:
885:The Lecturio Medical Concept Library
664:Spindle-cell squamous-cell carcinoma
324:Conjunctival squamous cell carcinoma
183:and radiotherapy are commonly used.
1453:Journal of Burn Care & Research
1041:"Squamous cell carcinoma pathology"
215:parathyroid hormone-related protein
193:Squamous-cell carcinoma of the lung
38:features of squamous-cell carcinoma
1496:"Basaloid Squamous Cell Carcinoma"
652:Clear-cell squamous-cell carcinoma
604:corresponding to markedly dilated
161:esophageal squamous-cell carcinoma
25:
482:(ICD-O) system lists a number of
134:Cutaneous squamous-cell carcinoma
698:"NCI Dictionary of Cancer Terms"
657:
645:
640:Basaloid squamous-cell carcinoma
633:
621:
424:
412:
400:
1617:International Journal of Cancer
1160:Last staff update: 19 July 2022
1100:Gulisa Turashvili, M.D., Ph.D.
1061:Gulisa Turashvili, M.D., Ph.D.
628:Adenoid squamous-cell carcinoma
293:Ovarian squamous cell carcinoma
18:Adenoid squamous cell carcinoma
543:Other histopathologic subtypes
343:Haematoxylin & eosin stain
213:causing ectopic production of
93:Human papillomavirus infection
1:
1465:10.1097/BCR.0000000000000432
1000:10.7860/JCDR/2017/16899.9771
1221:Berman JJ (November 2004).
807:"Squamous Cell Skin Cancer"
570:appearance under microscope
499:papillary thyroid carcinoma
1769:
297:squamous ovarian carcinoma
207:non-small-cell lung cancer
190:
114:
1708:10.1207/s15327914nc5402_3
1590:10.1016/j.nut.2009.02.002
1532:British Journal of Cancer
1498:. In Li, Xiaoming (ed.).
1395:Dermatology: 2-Volume Set
1138:"Adenocarcinoma overview"
1098:- Reference for entries:
1059:- Reference for entries:
851:10.1017/S0022215110002070
702:National Cancer Institute
486:subtypes and variants of
431:SCC, left ventral forearm
267:prostate-specific antigen
261:When associated with the
1272:Berman JJ (March 2004).
572:. Subtypes may include:
549:Erythroplasia of Queyrat
470:, or "secondary tumor".
247:Erythroplasia of Queyrat
1500:Squamous Cell Carcinoma
1189:10.15252/emmm.201911101
1176:EMBO Molecular Medicine
935:Robbins Basic Pathology
211:paraneoplastic syndrome
43:Squamous-cell carcinoma
1671:10.1093/ajcn/85.5.1401
1544:10.1038/sj.bjc.6601239
1291:10.1186/1471-2407-4-10
1240:10.1186/1471-2407-4-88
369:
356:
345:
202:
121:About 90% of cases of
112:
39:
1494:Radhi, Jasim (2012).
606:endoplasmic reticulum
362:
351:
337:
200:
159:may be due to either
110:
33:
1696:Nutrition and Cancer
1397:. St. Louis: Mosby.
377:physical examination
230:Human papillomavirus
123:head and neck cancer
117:Head and neck cancer
103:Head and neck cancer
51:epidermoid carcinoma
881:"Esophageal Cancer"
742:10.3892/or_00000397
1142:Pathology Outlines
1106:Pathology Outlines
1067:Pathology Outlines
370:
357:
346:
209:). It often has a
203:
173:painful swallowing
113:
80:, and response to
49:), also known as
40:
1630:10.1002/ijc.22061
1509:978-953-51-0024-9
1436:978-0-07-138076-8
1404:978-1-4160-2999-1
1349:on 23 August 2009
1339:978-92-832-2418-1
944:978-1-4160-2973-1
919:978-1-60547-781-7
887:. 26 October 2020
595:hydropic swelling
459:basement membrane
273:Vagina and cervix
157:Esophageal cancer
16:(Redirected from
1760:
1728:
1727:
1690:
1684:
1683:
1673:
1649:
1643:
1642:
1632:
1608:
1602:
1601:
1572:
1566:
1565:
1555:
1523:
1514:
1513:
1491:
1485:
1484:
1447:
1441:
1440:
1422:
1409:
1408:
1390:
1384:
1383:
1365:
1359:
1358:
1356:
1354:
1348:
1342:. Archived from
1331:
1320:
1314:
1313:
1303:
1293:
1269:
1263:
1262:
1252:
1242:
1218:
1212:
1211:
1201:
1191:
1167:
1161:
1159:
1153:
1145:
1133:
1127:
1123:
1117:
1109:
1094:
1088:
1084:
1078:
1070:
1055:
1049:
1048:
1036:
1030:
1029:
1019:
994:(5): QD01–QD02.
979:
973:
972:
970:
969:
955:
949:
948:
930:
924:
923:
903:
897:
896:
894:
892:
877:
871:
870:
834:
828:
827:
826:
825:
802:
796:
795:
793:
791:
781:
775:
774:
772:
771:
761:
755:
754:
744:
729:Oncology Reports
720:
714:
713:
711:
709:
694:
661:
649:
637:
625:
562:Marjolin's ulcer
554:Marjolin's ulcer
474:Tissue of origin
428:
416:
404:
88:By body location
67:digestive tracts
21:
1768:
1767:
1763:
1762:
1761:
1759:
1758:
1757:
1733:
1732:
1731:
1692:
1691:
1687:
1651:
1650:
1646:
1610:
1609:
1605:
1584:(7–8): 753–61.
1574:
1573:
1569:
1525:
1524:
1517:
1510:
1493:
1492:
1488:
1449:
1448:
1444:
1437:
1424:
1423:
1412:
1405:
1392:
1391:
1387:
1380:
1367:
1366:
1362:
1352:
1350:
1346:
1340:
1329:
1322:
1321:
1317:
1271:
1270:
1266:
1220:
1219:
1215:
1169:
1168:
1164:
1146:
1135:
1134:
1130:
1125:
1110:
1099:
1097:
1095:
1091:
1086:
1071:
1060:
1058:
1056:
1052:
1038:
1037:
1033:
990:(Case report).
981:
980:
976:
967:
965:
963:www.dynamed.com
957:
956:
952:
945:
932:
931:
927:
920:
905:
904:
900:
890:
888:
879:
878:
874:
836:
835:
831:
823:
821:
804:
803:
799:
789:
787:
783:
782:
778:
769:
767:
763:
762:
758:
722:
721:
717:
707:
705:
696:
695:
688:
684:
675:
669:
665:
662:
653:
650:
641:
638:
629:
626:
545:
537:keratoacanthoma
476:
439:
432:
429:
420:
417:
408:
405:
381:medical imaging
373:Medical history
332:
321:
313:schistosomiasis
309:
301:ovarian cancers
290:
275:
259:
241:Bowen's disease
227:
217:, resulting in
195:
189:
154:
142:
131:
119:
105:
90:
74:natural history
28:
23:
22:
15:
12:
11:
5:
1766:
1764:
1756:
1755:
1750:
1745:
1735:
1734:
1730:
1729:
1685:
1644:
1623:(8): 1953–60.
1603:
1567:
1538:(7): 1209–14.
1515:
1508:
1486:
1459:(1): e14–e22.
1442:
1435:
1410:
1403:
1385:
1378:
1360:
1338:
1315:
1264:
1213:
1162:
1128:
1089:
1050:
1031:
974:
950:
943:
925:
918:
898:
872:
829:
797:
776:
756:
735:(6): 1627–32.
715:
685:
683:
680:
674:
671:
667:
666:
663:
656:
654:
651:
644:
642:
639:
632:
630:
627:
620:
617:
616:
598:
591:
584:
566:
565:
551:
544:
541:
533:
532:
529:
526:
523:
520:
517:
514:
511:
508:
505:
502:
490:squamous-cell
475:
472:
448:squamous cells
438:
437:Classification
435:
434:
433:
430:
423:
421:
418:
411:
409:
406:
399:
389:histopathology
366:adenocarcinoma
331:
328:
320:
317:
315:is often SCC.
308:
305:
289:
286:
282:vaginal cancer
274:
271:
258:
255:
254:
253:
250:
244:
226:
223:
191:Main article:
188:
185:
165:adenocarcinoma
153:
150:
141:
138:
130:
127:
115:Main article:
104:
101:
89:
86:
59:squamous cells
57:that begin in
36:histopathology
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1765:
1754:
1751:
1749:
1746:
1744:
1741:
1740:
1738:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1689:
1686:
1681:
1677:
1672:
1667:
1664:(5): 1401–8.
1663:
1659:
1655:
1648:
1645:
1640:
1636:
1631:
1626:
1622:
1618:
1614:
1607:
1604:
1599:
1595:
1591:
1587:
1583:
1579:
1571:
1568:
1563:
1559:
1554:
1549:
1545:
1541:
1537:
1533:
1529:
1522:
1520:
1516:
1511:
1505:
1501:
1497:
1490:
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63:respiratory
1753:Epithelium
1737:Categories
1278:BMC Cancer
1227:BMC Cancer
968:2018-02-20
845:(1): 3–9.
824:2022-03-09
811:StatPearls
770:2010-09-22
708:9 November
682:References
673:Prevention
468:metastasis
452:carcinoma
444:stem cells
295:(oSCC) or
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1578:Nutrition
1284:(1): 10.
1233:(1): 88.
1008:2249-782X
492:neoplasms
488:malignant
330:Diagnosis
169:Dysphagia
152:Esophagus
82:treatment
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1748:Oncology
1716:16898861
1680:17490979
1639:16721782
1598:19394796
1562:14520448
1473:27679957
1353:27 March
1310:15113444
1259:15571625
1208:32128997
1150:cite web
1114:cite web
1075:cite web
1045:DermNetz
1026:28658855
891:6 August
867:28225556
859:20950510
819:28722968
790:15 March
751:19424646
602:vacuoles
464:invasive
263:prostate
257:Prostate
144:Primary
1724:1959103
1553:2394307
1481:3702018
1199:7136964
1017:5483757
613:nucleus
454:in situ
307:Bladder
234:in situ
140:Thyroid
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339:Biopsy
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1720:S2CID
1477:S2CID
1347:(PDF)
1330:(PDF)
863:S2CID
558:ulcer
288:Ovary
225:Penis
34:Main
1712:PMID
1676:PMID
1635:PMID
1594:PMID
1558:PMID
1504:ISBN
1469:PMID
1431:ISBN
1399:ISBN
1374:ISBN
1355:2010
1334:ISBN
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710:2016
610:cell
478:The
393:TP63
387:for
379:and
187:Lung
129:Skin
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1666:doi
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