297:
274:
171:
196:
303:
202:
2009:
1385:
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of
1564:
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity".
50:
1183:
oxidation and glucose uptake by adiponectin. In 2016, the
University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called
1437:
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif".
310:
209:
1725:
1176:
1487:
802:
783:
132:
1919:
1505:
Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014).
2083:
2054:
2073:
1362:
1344:
1983:
1718:
1685:
296:
1045:
1038:
273:
1827:
1711:
1331:
1310:
1950:
1691:
195:
170:
1327:
47:
1988:
1306:
1116:
1960:
1172:
112:
309:
208:
1945:
1775:
302:
201:
2047:
1955:
1750:
1132:
1625:"Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay"
1780:
1924:
1893:
851:
120:
1790:
1738:
832:
828:
2078:
1911:
1769:
1283:
2040:
1742:
184:
1703:
1244:
1973:
1843:
1636:
1574:
1518:
1446:
1395:
1278:
1185:
1160:
1136:
99:
1901:
1785:
1765:
1697:
1021:
996:
992:
988:
958:
933:
929:
925:
1488:
University of Tokyo to investigate data manipulation charges against six prominent research groups
1795:
1598:
1470:
1419:
144:
1017:
984:
954:
921:
1929:
1811:
1664:
1590:
1546:
1507:"Development of second generation peptides modulating cellular adiponectin receptor responses"
1462:
1411:
92:
40:
2024:
1266:
1217:
1212:
140:
1734:
1654:
1644:
1582:
1536:
1526:
1454:
1403:
1234:
389:
320:
264:
219:
364:
1139:. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic
1640:
1578:
1522:
1450:
1399:
1659:
1624:
1541:
1506:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
636:
631:
626:
621:
605:
600:
595:
590:
585:
580:
2067:
2020:
1859:
567:
1474:
1423:
1602:
1239:
382:
161:
124:
1649:
1623:
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013).
148:
1367:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1349:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1207:
1168:
465:
1968:
1879:
1458:
1249:
1180:
1144:
1140:
281:
178:
128:
1531:
1307:
ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070
1148:
747:
525:
403:
348:
335:
247:
234:
136:
1668:
1594:
1550:
1466:
1415:
1085:
1875:
1229:
1069:
896:
877:
1586:
1407:
1080:
1164:
1105:
863:
814:
69:
1053:
769:
2008:
1386:
adiponectin receptors that mediate antidiabetic metabolic effects".
732:
728:
2016:
1978:
1112:
116:
1707:
1167:
and AdipoR2, serve as receptors for globular and full-length
372:
2028:
537:
1938:
1910:
1892:
1868:
1852:
1836:
1820:
1804:
1758:
1749:
1010:
977:
947:
914:
1323:
1321:
1319:
1302:
1300:
1298:
718:positive regulation of cold-induced thermogenesis
319:
218:
1618:
1616:
1614:
1612:
16:Protein-coding gene in the species Homo sapiens
1500:
1498:
1496:
1380:
1378:
1376:
1328:GRCm38: Ensembl release 89: ENSMUSG00000030168
2048:
1719:
713:regulation of fatty acid biosynthetic process
8:
1490:ScienceInsider, Dennis Normile, Sep 20, 2016
2055:
2041:
1755:
1726:
1712:
1704:
743:
563:
484:transitional epithelium of urinary bladder
360:
259:
156:
58:
1658:
1648:
1540:
1530:
1920:Serine/threonine-specific protein kinase
1294:
678:adiponectin-activated signaling pathway
103:, adiponectin receptor 2, ACDCR2, PAQR2
632:intrinsic component of plasma membrane
581:adipokinetic hormone receptor activity
18:
653:positive regulation of glucose import
324:
285:
280:
223:
182:
177:
7:
2005:
2003:
1984:Lipoprotein receptor-related protein
1119:(PAQR) family, and is also known as
488:vestibular membrane of cochlear duct
601:protein heterodimerization activity
2027:. You can help Knowledge (XXG) by
1135:(GPCRs), AdipoR2 also possesses 7
1108:which in humans is encoded by the
1007:
974:
944:
911:
887:
868:
842:
819:
793:
774:
708:hormone-mediated signaling pathway
698:negative regulation of cell growth
542:
460:
398:
377:
14:
2007:
308:
301:
295:
272:
207:
200:
194:
169:
1828:Metabotropic glutamate receptor
2084:Human chromosome 12 gene stubs
1951:Tumor necrosis factor receptor
1439:Journal of Molecular Evolution
1179:ligand activities, as well as
1147:) and does not associate with
622:integral component of membrane
526:More reference expression data
1:
1989:Progestin and adipoQ receptor
1117:progestin and adipoQ receptor
492:epithelium of small intestine
293:
192:
2074:Genes on human chromosome 12
1650:10.1371/journal.pone.0063354
683:fatty acid metabolic process
1964:-Acetylglucosamine receptor
1946:Asialoglycoprotein receptor
1776:Protease-activated receptor
1133:G protein-coupled receptors
606:signaling receptor activity
2100:
2002:
1956:Immunoglobulin superfamily
1751:G protein-coupled receptor
1696:gene details page in the
512:tunica adventitia of aorta
1781:Neurotransmitter receptor
1459:10.1007/s00239-004-0375-2
1363:"Mouse PubMed Reference:"
1345:"Human PubMed Reference:"
1084:
1079:
1075:
1068:
1052:
1046:Chr 6: 119.33 – 119.39 Mb
1033:
1014:
981:
970:
951:
918:
907:
894:
890:
875:
871:
862:
849:
845:
826:
822:
813:
800:
796:
781:
777:
768:
753:
746:
742:
726:
596:identical protein binding
566:
562:
550:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1925:Receptor tyrosine kinase
1894:Ligand-gated ion channel
1532:10.3389/fchem.2014.00093
1115:. It is a member of the
1791:Biogenic amine receptor
1912:Enzyme-linked receptor
1770:Prostaglandin receptor
1743:cell surface receptors
1511:Frontiers in Chemistry
1284:Adiponectin receptor 1
1171:and mediate increased
1098:Adiponectin receptor 2
1039:Chr 12: 1.69 – 1.79 Mb
688:vascular wound healing
1161:adiponectin receptors
1137:transmembrane domains
496:epithelium of stomach
185:Chromosome 12 (human)
1974:Transferrin receptor
1690:genome location and
1279:Adiponectin receptor
1186:Ordinary_researchers
703:fatty acid oxidation
663:response to nutrient
508:white adipose tissue
480:brown adipose tissue
422:right adrenal cortex
326:6 F1|6 56.78 cM
287:Chromosome 6 (mouse)
62:List of PDB id codes
35:Available structures
1902:Purinergic receptor
1786:Purinergic receptor
1766:Eicosanoid receptor
1698:UCSC Genome Browser
1641:2013PLoSO...863354S
1587:10.1038/nature12656
1579:2013Natur.503..493O
1523:2014FrCh....2...93O
1451:2005JMolE..61..372T
1408:10.1038/nature01705
1400:2003Natur.423..762Y
658:glucose homeostasis
586:adiponectin binding
446:epithelium of colon
434:left adrenal cortex
149:ADIPOR2 - orthologs
2015:This article on a
1844:Pheromone receptor
1796:Olfactory receptor
852:ENSMUSG00000030168
646:Biological process
615:Cellular component
574:Molecular function
504:left lobe of liver
450:hippocampus proper
430:left adrenal gland
2036:
2035:
1997:
1996:
1930:Guanylate cyclase
1888:
1887:
1812:Secretin receptor
1735:Membrane proteins
1095:
1094:
1091:
1090:
1064:
1063:
1029:
1028:
1004:
1003:
966:
965:
941:
940:
903:
902:
884:
883:
858:
857:
839:
838:
809:
808:
790:
789:
738:
737:
693:heart development
591:metal ion binding
558:
557:
554:
553:
532:
531:
519:
518:
476:lactiferous gland
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
2091:
2057:
2050:
2043:
2011:
2004:
1756:
1728:
1721:
1714:
1705:
1673:
1672:
1662:
1652:
1620:
1607:
1606:
1561:
1555:
1554:
1544:
1534:
1502:
1491:
1485:
1479:
1478:
1434:
1428:
1427:
1382:
1371:
1370:
1359:
1353:
1352:
1341:
1335:
1325:
1314:
1304:
1235:Deoxyschizandrin
1143:, extracellular
1077:
1076:
1048:
1041:
1024:
1008:
999:
975:
971:RefSeq (protein)
961:
945:
936:
912:
888:
869:
843:
820:
794:
775:
744:
673:female pregnancy
668:lipid metabolism
564:
543:
528:
468:
466:Top expressed in
461:
438:substantia nigra
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
2099:
2098:
2094:
2093:
2092:
2090:
2089:
2088:
2064:
2063:
2062:
2061:
2000:
1998:
1993:
1939:Other/ungrouped
1934:
1906:
1884:
1864:
1848:
1832:
1816:
1800:
1745:
1732:
1681:
1676:
1622:
1621:
1610:
1573:(7477): 493–9.
1563:
1562:
1558:
1504:
1503:
1494:
1486:
1482:
1436:
1435:
1431:
1394:(6941): 762–9.
1384:
1383:
1374:
1361:
1360:
1356:
1343:
1342:
1338:
1326:
1317:
1305:
1296:
1292:
1275:
1263:
1258:
1226:
1204:
1199:
1194:
1157:
1129:
1086:View/Edit Mouse
1081:View/Edit Human
1044:
1037:
1034:Location (UCSC)
1020:
1016:
995:
991:
987:
983:
957:
953:
932:
928:
924:
920:
833:ENSG00000285070
831:
829:ENSG00000006831
722:
641:
637:plasma membrane
610:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
416:
414:corpus callosum
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
2097:
2095:
2087:
2086:
2081:
2076:
2066:
2065:
2060:
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2052:
2045:
2037:
2034:
2033:
2012:
1995:
1994:
1992:
1991:
1986:
1981:
1976:
1971:
1966:
1958:
1953:
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1935:
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1927:
1922:
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1679:External links
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500:pyloric antrum
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365:RNA expression
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15:
13:
10:
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3:
2:
2096:
2085:
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2079:7TM receptors
2077:
2075:
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2069:
2058:
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2021:chromosome 12
2018:
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1899:
1897:
1895:
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1881:
1877:
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1873:
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1867:
1861:
1860:cAMP receptor
1858:
1857:
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1688:
1683:
1682:
1678:
1670:
1666:
1661:
1656:
1651:
1646:
1642:
1638:
1635:(5): e63354.
1634:
1630:
1626:
1619:
1617:
1615:
1613:
1609:
1604:
1600:
1596:
1592:
1588:
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1460:
1456:
1452:
1448:
1445:(3): 372–80.
1444:
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1409:
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1401:
1397:
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1201:
1196:
1191:
1189:
1187:
1182:
1178:
1174:
1170:
1166:
1162:
1154:
1152:
1150:
1146:
1142:
1138:
1134:
1126:
1124:
1122:
1118:
1114:
1111:
1107:
1103:
1099:
1087:
1082:
1078:
1074:
1071:
1067:
1060:
1058:
1055:
1051:
1047:
1043:
1040:
1036:
1032:
1025:
1023:
1019:
1013:
1009:
1006:
1000:
998:
994:
990:
986:
980:
976:
973:
969:
962:
960:
956:
950:
946:
943:
937:
935:
931:
927:
923:
917:
913:
910:
908:RefSeq (mRNA)
906:
899:
898:
893:
889:
886:
880:
879:
874:
870:
867:
865:
861:
854:
853:
848:
844:
841:
835:
834:
830:
825:
821:
818:
816:
812:
805:
804:
799:
795:
792:
786:
785:
780:
776:
773:
771:
767:
764:
761:
759:
756:
752:
749:
745:
741:
734:
730:
725:
719:
716:
714:
711:
709:
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704:
701:
699:
696:
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689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
650:
648:
645:
644:
638:
635:
633:
630:
628:
625:
623:
620:
619:
617:
614:
613:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
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412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
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350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
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197:
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176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2029:expanding it
2014:
1999:
1961:
1692:
1686:
1632:
1628:
1570:
1566:
1559:
1514:
1510:
1483:
1442:
1438:
1432:
1391:
1387:
1366:
1357:
1348:
1339:
1240:Parthenolide
1158:
1130:
1120:
1109:
1101:
1097:
1096:
1022:NP_001342621
1015:
997:NP_001362294
993:NP_001362293
989:NP_001362292
982:
959:NM_001355692
952:
934:NM_001375365
930:NM_001375364
926:NM_001375363
919:
895:
876:
850:
827:
801:
782:
762:
757:
388:
381:
347:119,394,665
334:119,330,111
108:External IDs
67:
1969:Neuropilins
1256:Antagonists
1224:Non-peptide
1208:Adiponectin
1169:adiponectin
1131:Similar to
86:Identifiers
2068:Categories
1880:smoothened
1334:, May 2017
1313:, May 2017
1290:References
1250:Taxifoliol
1181:fatty acid
1149:G proteins
1145:C-terminus
1141:N-terminus
426:right lung
418:C1 segment
392:(ortholog)
246:1,788,674
233:1,688,574
129:HomoloGene
2019:on human
1739:receptors
1245:Syringing
1127:Structure
1018:NP_932102
985:NP_078827
955:NM_197985
922:NM_024551
748:Orthologs
137:GeneCards
1876:Frizzled
1669:23691032
1629:PLOS ONE
1595:24172895
1551:25368867
1475:31473802
1467:16044242
1424:52860797
1416:12802337
1330:–
1309:–
1273:See also
1230:AdipoRon
1197:Agonists
1155:Function
1070:Wikidata
727:Sources:
627:membrane
225:12p13.33
1869:Class F
1853:Class E
1837:Class D
1821:Class C
1805:Class B
1759:Class A
1693:ADIPOR2
1687:ADIPOR2
1660:3653934
1637:Bibcode
1603:4447039
1575:Bibcode
1542:4201147
1519:Bibcode
1447:Bibcode
1396:Bibcode
1332:Ensembl
1311:Ensembl
1267:ADP-400
1261:Peptide
1218:ADP-399
1213:ADP-355
1202:Peptide
1192:Ligands
1165:AdipoR1
1110:ADIPOR2
1106:protein
1104:) is a
1102:AdipoR2
864:UniProt
815:Ensembl
754:Species
733:QuickGO
367:pattern
141:ADIPOR2
100:ADIPOR2
93:Aliases
22:ADIPOR2
1684:Human
1667:
1657:
1601:
1593:
1567:Nature
1549:
1539:
1517:: 93.
1473:
1465:
1422:
1414:
1388:Nature
1177:PPAR-α
1056:search
1054:PubMed
897:Q8BQS5
878:Q86V24
770:Entrez
538:BioGPS
117:607946
2023:is a
1599:S2CID
1471:S2CID
1420:S2CID
1121:PAQR2
803:68465
784:79602
763:Mouse
758:Human
729:Amigo
442:liver
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:56119
125:93830
2025:stub
2017:gene
1979:EDAR
1665:PMID
1591:PMID
1547:PMID
1463:PMID
1412:PMID
1175:and
1173:AMPK
1159:The
1113:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:3WXW
51:RCSB
48:PDBe
1655:PMC
1645:doi
1583:doi
1571:503
1537:PMC
1527:doi
1455:doi
1404:doi
1392:423
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
2070::
1741::
1737:,
1663:.
1653:.
1643:.
1631:.
1627:.
1611:^
1597:.
1589:.
1581:.
1569:.
1545:.
1535:.
1525:.
1513:.
1509:.
1495:^
1469:.
1461:.
1453:.
1443:61
1441:.
1418:.
1410:.
1402:.
1390:.
1375:^
1365:.
1347:.
1318:^
1297:^
1188:.
1163:,
1151:.
1123:.
731:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
2056:e
2049:t
2042:v
2031:.
1962:N
1878:/
1772:)
1768:(
1727:e
1720:t
1713:v
1700:.
1671:.
1647::
1639::
1633:8
1605:.
1585::
1577::
1553:.
1529::
1521::
1515:2
1477:.
1457::
1449::
1426:.
1406::
1398::
1369:.
1351:.
1100:(
267:)
164:)
147::
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