42:
587:(EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Seffalair Spiromax, intended for the treatment of asthma. The applicant for this medicinal product is Teva B.V. The CHMP also recommended the granting of a marketing authorization for the duplicate product BroPair Spiromax. Seffalair Spiromax and BroPair Spiromax were both approved for medical use in the European Union in March 2021.
2683:
506:
of inhaled steroids. Other side effects from this drug combination may include increased blood pressure, change in heart rate, an irregular heartbeat, increased risk of osteoporosis, cataracts, and glaucoma. Studies have demonstrated the safety of inhaled fluticasone propionate in children. A systematic review published in 2013 found no significant adverse effect on the function of the
2711:
505:
While the use of inhaled steroids and long-acting beta2‑adrenergic agonists are recommended for the resulting improvement in control of symptoms of asthma, concerns have been raised that salmeterol may increase the risk of death due to asthma, and this additional risk is not reduced by the addition
489:
component of the combination which decreases inflammation in the lungs. This leads to improvement in breathing. Salmeterol, a long-acting beta-adrenoceptor agonist, treats constriction of the airways. The combination of both is meant to be used as maintenance therapy and not as a rescue therapy for
611:(GSK) and the United States, in which GSK agreed to pay $ 1.043 billion; the United States said that GSK promoted off-label uses of Advair and paid kickbacks to healthcare professionals to sell this drug, among others.
1196:
243:
198:
1833:
1189:
566:. Increased cyclic AMP levels lead to a relaxation of bronchial smooth muscles. Additionally, cyclic AMP inhibits the release of mediators of immediate hypersensitivity.
2620:
1818:
1182:
580:
1858:
96:
990:
507:
1828:
1164:
1023:
502:, commonly known as yeast infection or thrush. Rinsing the mouth with water after inhaling the medication decreases the risk of developing this condition.
466:
version was approved in the United States in 2019. In 2022, it was the 59th most commonly prescribed medication in the United States, with more than 11
2088:
628:
498:
The common side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with
2613:
1912:
1697:
1362:
1316:
1214:
452:
429:
74:
2746:
2230:
2003:
554:
all of which contribute to inflammation, a large component in the pathogenesis of asthma. Salmeterol works by stimulating intracellular
1853:
147:
952:
Muley P, Shah M, Muley A (July 2013). "Safety of inhaled fluticasone propionate therapy for pediatric asthma - a systematic review".
2736:
2627:
1848:
1843:
732:
893:
2634:
693:
662:
2741:
2651:
2560:
1898:
1715:
808:
228:
128:
2606:
1868:
1838:
846:
1968:
1808:
2701:
2731:
814:
2148:
1929:
1165:"GlaxoSmithKline to Plead Guilty and Pay $ 3 Billion to Resolve Fraud Allegations and Failure to Report Safety Data"
1001:
1480:
1206:
456:
1034:
510:, growth, and bone mineral density in asthmatic children when inhaled fluticasone is used for up to three months.
2325:
1090:
1061:
1028:
995:
584:
530:
receptor agonist. Fluticasone works as a potent anti-inflammatory agent, inhibiting multiple cell types such as
2662:
2555:
2329:
2212:
2098:
1998:
1813:
1428:
1240:
2108:
913:"Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths"
2093:
1917:
184:
1174:
41:
2379:
2168:
1883:
1863:
1669:
1624:
1543:
1505:
1414:
1139:
1114:
519:
417:
413:
57:
2656:
2083:
1878:
1873:
1823:
1530:
1056:
755:
106:
2008:
1573:
1563:
1085:
2053:
1548:
896:. British Thoracic Society & Scottish Intercollegiate Guidelines Network (SIGN). Archived from
307:
1558:
1553:
1538:
1510:
158:
1352:
2412:
1961:
969:
934:
780:
728:
486:
280:
267:
255:
86:
929:
912:
868:
361:
2686:
2511:
2399:
1581:
961:
924:
756:"Fluticasone and Salmeterol inhalation - FDA prescribing information, side effects and uses"
499:
436:
316:
897:
2715:
2539:
2501:
2496:
2163:
2018:
1525:
1448:
1227:
608:
527:
2575:
2521:
2486:
2320:
1923:
1739:
1472:
1296:
555:
448:
447:, and heart problems. Safety in pregnancy and breastfeeding is unclear. Fluticasone, a
62:
33:
27:
Formulation used in the management of asthma and chronic obstructive pulmonary disease
2725:
2570:
2491:
2158:
2153:
2058:
1644:
1639:
1614:
1515:
1485:
1453:
1438:
120:
341:
2580:
2565:
2516:
2285:
1954:
1777:
1649:
1634:
1609:
1458:
1443:
1342:
1218:
463:
211:
206:
838:
965:
2529:
2506:
2178:
1752:
1728:
1687:
1677:
1629:
1619:
1500:
1495:
1384:
1333:
1306:
1301:
440:
114:
2585:
2534:
2442:
2394:
2208:
2198:
2193:
2183:
2063:
1792:
1787:
1723:
1682:
1659:
1604:
1586:
1490:
1433:
1394:
1389:
1379:
1374:
1347:
1338:
1328:
1292:
1282:
1277:
1272:
1267:
1257:
1252:
694:"Advair HFA- fluticasone propionate and salmeterol xinafoate aerosol, metered"
563:
551:
547:
543:
535:
523:
421:
352:
191:
69:
462:
The combination was approved for medical use in the United States in 2000. A
17:
2668:
2452:
2432:
2389:
2384:
2364:
2359:
2300:
2270:
2250:
2203:
2188:
2173:
1782:
1772:
1747:
1410:
1287:
1262:
531:
479:
100:
973:
938:
869:"Fluticasone; Salmeterol Drug Usage Statistics, United States, 2013 - 2022"
985:
983:
439:, headache, and cough. Serious side effects may include worsening asthma,
424:, a long-acting beta2‑adrenergic agonist. It is used in the management of
2437:
2427:
2422:
2417:
2374:
2310:
2305:
2280:
2260:
2245:
2240:
2143:
1705:
1596:
1231:
559:
539:
142:
607:
In 2012, Advair was part of a larger civil settlement agreement between
2407:
2369:
2351:
2315:
2275:
2255:
2235:
2103:
2078:
2073:
2068:
1977:
444:
327:
2447:
2295:
2290:
2265:
2033:
2013:
1893:
1418:
1210:
425:
381:
1888:
1422:
596:
2457:
372:
286:
261:
1950:
1178:
1167:. Department of Justice: Office of Public Affairs. 2 July 2012.
911:
Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE (June 2006).
781:"Fluticasone / salmeterol Pregnancy and Breastfeeding Warnings"
274:
137:
894:"Guideline 101: British Guideline on the Management of Asthma"
432:(COPD). It is used by inhaling the medication into the lungs.
727:(76 ed.). Pharmaceutical Press. 2018. pp. 263–264.
663:"Advair Diskus- fluticasone propionate and salmeterol powder"
237:
169:
657:
655:
653:
651:
649:
250:
451:, works by decreasing inflammation while salmeterol, a
395:
1946:
688:
686:
684:
2699:
46:
Fluticasone propionate (top) and salmeterol (bottom)
2644:
2598:
2548:
2477:
2470:
2344:
2223:
2131:
2124:
2117:
2044:
2028:
1991:
1984:
1834:
Fluticasone furoate/umeclidinium bromide/vilanterol
1801:
1765:
1737:
1714:
1696:
1668:
1658:
1595:
1572:
1524:
1471:
1403:
1361:
1315:
1239:
1226:
371:
351:
326:
306:
301:
227:
222:
197:
183:
157:
127:
113:
95:
85:
80:
68:
56:
51:
803:
801:
340:
2621:GlaxoSmithKline Services Unlimited v Commission
1819:Beclometasone/formoterol/glycopyrronium bromide
315:
629:"Seroflo Multihaler (Cipla Australia Pty Ltd)"
599:the first generic approval for Advair Diskus.
581:Committee for Medicinal Products for Human Use
1962:
1859:Indacaterol/glycopyrronium bromide/mometasone
1190:
8:
1829:Budesonide/glycopyrronium bromide/formoterol
146:
32:
750:
748:
746:
744:
294:In general: â„ž (Prescription only)
2474:
2128:
2121:
1988:
1969:
1955:
1947:
1665:
1236:
1197:
1183:
1175:
809:"FDA approves first generic Advair Diskus"
360:
991:"Seffalair Spiromax: Pending EC decision"
928:
1115:"Seffalair Spiromax Product information"
930:10.7326/0003-4819-144-12-200606200-00126
725:British national formulary : BNF 76
2706:
2614:Christopher v. SmithKline Beecham Corp.
1024:"BroPair Spiromax: Pending EC decision"
719:
717:
715:
620:
119:
1698:Arachidonate 5-lipoxygenase inhibitors
1140:"BroPair Spiromax Product information"
485:Fluticasone, a corticosteroid, is the
31:
2089:Recherche et Industrie Thérapeutiques
453:long-acting beta-adrenoceptor agonist
430:chronic obstructive pulmonary disease
105:
75:Long-acting beta-adrenoceptor agonist
7:
1894:Theophylline/ephedrine/phenobarbital
1144:Union Register of medicinal products
1119:Union Register of medicinal products
210:
2004:GlaxoSmithKline Pharmaceuticals Ltd
849:from the original on 30 August 2024
508:hypothalamic–pituitary–adrenal axis
380:
331:
1889:Theophylline/ephedrine/hydroxyzine
1854:Indacaterol/glycopyrronium bromide
633:Department of Health and Ages Care
522:, a synthetic corticosteroid, and
25:
2628:United States v. Glaxo Group Ltd.
1879:Salbutamol (albuterol)/budesonide
1849:Glycopyrronium bromide/formoterol
1844:Fluticasone propionate/salmeterol
1033:. 1 February 2021. Archived from
1000:. 1 February 2021. Archived from
595:In January 2019, the FDA granted
420:, an inhaled corticosteroid; and
107:FDA Professional Drug Information
2709:
2682:
2681:
2635:United States v. GlaxoSmithKline
1716:Thromboxane receptor antagonists
518:Fluticasone/salmeterol contains
91:Advair, Seretide, Cyplos, others
40:
2652:Drug Industry Documents Archive
1899:Umeclidinium bromide/vilanterol
2607:Canada v. GlaxoSmithKline Inc.
1869:Ipratropium bromide/salbutamol
1839:Fluticasone furoate/vilanterol
1454:Orciprenaline (metaproterenol)
1:
1809:Aclidinium bromide/formoterol
1297:Levosalbutamol (levalbuterol)
482:for the treatment of asthma.
1444:Isoprenaline (isoproterenol)
966:10.2174/15748863113089990038
815:Food and Drug Administration
455:(LABA), works by activating
435:Common side effects include
408:, sold under the brand name
1419:+theophylline/phenobarbital
1207:obstructive airway diseases
457:beta-2 adrenergic receptors
2763:
2747:Drugs developed by GSK plc
526:, a selective long-acting
478:Fluticasone/salmeterol is
148:Fluticasone and salmeterol
2677:
2109:Smith, Kline & French
1907:
1091:European Medicines Agency
1062:European Medicines Agency
1057:"Seffalair Spiromax EPAR"
1029:European Medicines Agency
996:European Medicines Agency
585:European Medicines Agency
391:
39:
2737:Combination asthma drugs
2099:S. E. Massengill Company
1999:GlaxoSmithKline Pakistan
1814:Beclometasone/formoterol
1423:theophylline/hydroxyzine
1363:Ultra-long-acting β
2094:Reliant Pharmaceuticals
1670:Leukotriene antagonists
1086:"BroPair Spiromax EPAR"
470:million prescriptions.
2742:Combination COPD drugs
1884:Theophylline/ephedrine
1864:Indacaterol/mometasone
1625:Choline theophyllinate
1544:Glycopyrronium bromide
1506:Fluticasone propionate
1293:Salbutamol (albuterol)
520:fluticasone propionate
418:fluticasone propionate
416:medication containing
414:fixed-dose combination
406:Fluticasone/salmeterol
58:Fluticasone propionate
34:Fluticasone/salmeterol
2657:GlaxoSmithKline Prize
2084:Human Genome Sciences
1874:Mometasone/formoterol
1824:Budesonide/formoterol
1574:Mast cell stabilizers
1531:muscarinic antagonist
839:"The Top 300 of 2022"
579:In January 2021, the
562:in the production of
2054:Allen & Hanburys
2009:Stiefel Laboratories
1802:Combination products
1564:Umeclidinium bromide
2732:Antiasthmatic drugs
1549:Ipratropium bromide
1241:Short-acting β
1004:on 10 February 2021
954:Current Drug Safety
591:Generic equivalents
570:Society and culture
514:Mechanism of action
412:among others, is a
270:(Prescription only)
246:(Prescription only)
36:
2561:Silas M. Burroughs
2104:SmithKline Beecham
2069:Burroughs Wellcome
1934:Never to phase III
1559:Tiotropium bromide
1554:Oxitropium bromide
1539:Aclidinium bromide
1317:Long-acting β
558:, which acts as a
2697:
2696:
2594:
2593:
2466:
2465:
2340:
2339:
2040:
2039:
1944:
1943:
1761:
1760:
1467:
1466:
1095:. 25 January 2021
1066:. 25 January 2021
900:on 18 April 2015.
603:Civil settlements
490:sudden symptoms.
487:anti-inflammatory
403:
402:
290:
278:
265:
253:
241:
173:
140:
16:(Redirected from
2754:
2714:
2713:
2712:
2705:
2685:
2684:
2512:Patrick Vallance
2475:
2204:Wellbutrin/Zyban
2129:
2122:
1989:
1971:
1964:
1957:
1948:
1666:
1526:Anticholinergics
1237:
1199:
1192:
1185:
1176:
1169:
1168:
1161:
1155:
1154:
1152:
1150:
1136:
1130:
1129:
1127:
1125:
1111:
1105:
1104:
1102:
1100:
1082:
1076:
1075:
1073:
1071:
1053:
1047:
1046:
1044:
1042:
1037:on 13 April 2021
1020:
1014:
1013:
1011:
1009:
987:
978:
977:
949:
943:
942:
932:
917:Ann. Intern. Med
908:
902:
901:
890:
884:
883:
881:
879:
865:
859:
858:
856:
854:
835:
829:
828:
826:
824:
805:
796:
795:
793:
791:
777:
771:
770:
768:
766:
752:
739:
738:
721:
710:
709:
707:
705:
690:
679:
678:
676:
674:
659:
644:
643:
641:
639:
625:
500:oral candidiasis
469:
399:
398:
384:
364:
344:
334:
333:
319:
288:
285:
276:
273:
263:
260:
252:
249:
239:
236:
214:
171:
168:
150:
139:
136:
123:
109:
44:
37:
35:
21:
2762:
2761:
2757:
2756:
2755:
2753:
2752:
2751:
2722:
2721:
2720:
2710:
2708:
2700:
2698:
2693:
2673:
2640:
2590:
2544:
2540:Laurie Glimcher
2507:Manvinder Banga
2502:Roy M. Anderson
2497:Simon Dingemans
2479:
2462:
2336:
2219:
2113:
2046:
2036:
2024:
2019:ViiV Healthcare
1980:
1975:
1945:
1940:
1939:
1924:Clinical trials
1903:
1797:
1757:
1740:PDE4 inhibitors
1733:
1710:
1692:
1654:
1591:
1568:
1529:
1520:
1473:Glucocorticoids
1463:
1449:Methylephedrine
1399:
1366:
1357:
1320:
1311:
1244:
1222:
1203:
1173:
1172:
1163:
1162:
1158:
1148:
1146:
1138:
1137:
1133:
1123:
1121:
1113:
1112:
1108:
1098:
1096:
1084:
1083:
1079:
1069:
1067:
1055:
1054:
1050:
1040:
1038:
1022:
1021:
1017:
1007:
1005:
989:
988:
981:
951:
950:
946:
910:
909:
905:
892:
891:
887:
877:
875:
867:
866:
862:
852:
850:
837:
836:
832:
822:
820:
819:(Press release)
807:
806:
799:
789:
787:
779:
778:
774:
764:
762:
754:
753:
742:
735:
723:
722:
713:
703:
701:
692:
691:
682:
672:
670:
661:
660:
647:
637:
635:
627:
626:
622:
617:
609:GlaxoSmithKline
605:
593:
577:
572:
528:beta-adrenergic
516:
496:
476:
467:
394:
392:
387:
367:
347:
330:
322:
297:
218:
186:
179:
160:
153:
47:
28:
23:
22:
15:
12:
11:
5:
2760:
2758:
2750:
2749:
2744:
2739:
2734:
2724:
2723:
2719:
2718:
2695:
2694:
2692:
2691:
2678:
2675:
2674:
2672:
2671:
2666:
2659:
2654:
2648:
2646:
2642:
2641:
2639:
2638:
2631:
2624:
2617:
2610:
2602:
2600:
2596:
2595:
2592:
2591:
2589:
2588:
2583:
2578:
2576:Henry Wellcome
2573:
2568:
2563:
2558:
2556:Thomas Beecham
2552:
2550:
2546:
2545:
2543:
2542:
2537:
2532:
2527:
2524:
2522:Lynn Elsenhans
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2487:Philip Hampton
2483:
2481:
2472:
2468:
2467:
2464:
2463:
2461:
2460:
2455:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2413:Goody's Powder
2410:
2405:
2402:
2397:
2392:
2387:
2382:
2377:
2372:
2367:
2362:
2357:
2354:
2348:
2346:
2342:
2341:
2338:
2337:
2335:
2334:
2323:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2273:
2268:
2263:
2258:
2253:
2248:
2243:
2238:
2233:
2227:
2225:
2221:
2220:
2218:
2217:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2171:
2166:
2161:
2156:
2151:
2146:
2141:
2135:
2133:
2126:
2119:
2115:
2114:
2112:
2111:
2106:
2101:
2096:
2091:
2086:
2081:
2079:Glaxo Wellcome
2076:
2071:
2066:
2061:
2056:
2050:
2048:
2042:
2041:
2038:
2037:
2032:
2030:
2026:
2025:
2023:
2022:
2016:
2011:
2006:
2001:
1995:
1993:
1986:
1982:
1981:
1976:
1974:
1973:
1966:
1959:
1951:
1942:
1941:
1938:
1937:
1936:
1935:
1932:
1921:
1915:
1909:
1908:
1905:
1904:
1902:
1901:
1896:
1891:
1886:
1881:
1876:
1871:
1866:
1861:
1856:
1851:
1846:
1841:
1836:
1831:
1826:
1821:
1816:
1811:
1805:
1803:
1799:
1798:
1796:
1795:
1790:
1785:
1780:
1775:
1769:
1767:
1766:Others/unknown
1763:
1762:
1759:
1758:
1756:
1755:
1750:
1744:
1742:
1735:
1734:
1732:
1731:
1726:
1720:
1718:
1712:
1711:
1709:
1708:
1702:
1700:
1694:
1693:
1691:
1690:
1685:
1680:
1674:
1672:
1663:
1656:
1655:
1653:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1601:
1599:
1593:
1592:
1590:
1589:
1584:
1578:
1576:
1570:
1569:
1567:
1566:
1561:
1556:
1551:
1546:
1541:
1535:
1533:
1522:
1521:
1519:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1477:
1475:
1469:
1468:
1465:
1464:
1462:
1461:
1456:
1451:
1446:
1441:
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1407:
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1400:
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1387:
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1369:
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1325:
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1299:
1290:
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1260:
1255:
1249:
1247:
1242:
1234:
1224:
1223:
1204:
1202:
1201:
1194:
1187:
1179:
1171:
1170:
1156:
1131:
1106:
1077:
1048:
1015:
979:
960:(3): 186–194.
944:
923:(12): 904–12.
903:
885:
860:
830:
797:
772:
740:
733:
711:
680:
669:. 30 June 2023
645:
619:
618:
616:
613:
604:
601:
592:
589:
583:(CHMP) of the
576:
573:
571:
568:
556:adenyl cyclase
515:
512:
495:
492:
475:
472:
449:corticosteroid
401:
400:
389:
388:
386:
385:
377:
375:
369:
368:
366:
365:
357:
355:
349:
348:
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258:
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233:
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201:
195:
194:
189:
187:administration
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165:
163:
155:
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151:
133:
131:
125:
124:
117:
111:
110:
103:
93:
92:
89:
83:
82:
78:
77:
72:
66:
65:
63:Glucocorticoid
60:
54:
53:
52:Combination of
49:
48:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2759:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2729:
2727:
2717:
2707:
2703:
2690:
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2676:
2670:
2667:
2665:
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2637:
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2632:
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2625:
2623:
2622:
2618:
2616:
2615:
2611:
2609:
2608:
2604:
2603:
2601:
2597:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2571:John K. Smith
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2553:
2551:
2547:
2541:
2538:
2536:
2533:
2531:
2528:
2526:Jesse Goodman
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2492:Emma Walmsley
2490:
2488:
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2484:
2482:
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2459:
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2239:
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2234:
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2229:
2228:
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2222:
2216:
2215:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2190:
2187:
2185:
2184:Paxil/Seroxat
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2136:
2134:
2130:
2127:
2123:
2120:
2116:
2110:
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2065:
2062:
2060:
2059:Beecham Group
2057:
2055:
2052:
2051:
2049:
2045:Predecessors,
2043:
2035:
2031:
2027:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
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1994:
1990:
1987:
1983:
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1972:
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1933:
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1925:
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1916:
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1900:
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1800:
1794:
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1779:
1776:
1774:
1771:
1770:
1768:
1764:
1754:
1751:
1749:
1746:
1745:
1743:
1741:
1738:Non-xanthine
1736:
1730:
1727:
1725:
1722:
1721:
1719:
1717:
1713:
1707:
1704:
1703:
1701:
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1679:
1676:
1675:
1673:
1671:
1667:
1664:
1661:
1657:
1651:
1648:
1646:
1645:Proxyphylline
1643:
1641:
1640:Etamiphylline
1638:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1616:
1615:Aminophylline
1613:
1611:
1608:
1606:
1603:
1602:
1600:
1598:
1594:
1588:
1585:
1583:
1580:
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1565:
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1547:
1545:
1542:
1540:
1537:
1536:
1534:
1532:
1527:
1523:
1517:
1516:Triamcinolone
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1486:Betamethasone
1484:
1482:
1481:Beclometasone
1479:
1478:
1476:
1474:
1470:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1439:Hexoprenaline
1437:
1435:
1432:
1430:
1427:
1424:
1420:
1416:
1415:+theophylline
1412:
1409:
1408:
1406:
1402:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
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751:
749:
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745:
741:
736:
734:9780857113382
730:
726:
720:
718:
716:
712:
700:. 23 May 2024
699:
695:
689:
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343:
339:
338:
336:
329:
325:
318:
314:
313:
311:
309:
305:
300:
293:
291: Rx-only
284:
282:
272:
269:
259:
257:
248:
245:
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230:
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213:
208:
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196:
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156:
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135:
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130:
126:
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118:
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108:
104:
102:
98:
94:
90:
88:
84:
81:Clinical data
79:
76:
73:
71:
67:
64:
61:
59:
55:
50:
43:
38:
30:
19:
18:Advair Diskus
2687:
2663:Side Effects
2661:
2633:
2626:
2619:
2612:
2605:
2581:Andrew Witty
2566:Mahlon Kline
2517:Vivienne Cox
2330:
2286:H5N1 vaccine
2213:
2138:
2047:acquisitions
1985:Subsidiaries
1778:Ensifentrine
1650:Theophylline
1635:Enprofylline
1610:Ambuphylline
1582:Cromoglicate
1459:Racephedrine
1343:Arformoterol
1159:
1147:. Retrieved
1143:
1134:
1122:. Retrieved
1118:
1109:
1097:. Retrieved
1089:
1080:
1068:. Retrieved
1060:
1051:
1039:. Retrieved
1035:the original
1027:
1018:
1006:. Retrieved
1002:the original
994:
957:
953:
947:
920:
916:
906:
898:the original
888:
876:. Retrieved
872:
863:
851:. Retrieved
842:
833:
821:. Retrieved
812:
788:. Retrieved
784:
775:
763:. Retrieved
759:
724:
702:. Retrieved
697:
671:. Retrieved
666:
636:. Retrieved
632:
623:
606:
594:
578:
575:Legal status
517:
504:
497:
494:Side effects
484:
477:
474:Medical uses
461:
434:
409:
405:
404:
393:
229:Legal status
223:Legal status
129:License data
29:
2530:Judy Lewent
1920:from market
1753:Roflumilast
1729:Seratrodast
1688:Zafirlukast
1678:Montelukast
1630:Doxofylline
1620:Bamifylline
1501:Flunisolide
1496:Ciclesonide
1429:Epinephrine
1385:Indacaterol
1334:Clenbuterol
1307:Tulobuterol
1302:Terbutaline
1228:Adrenergics
704:8 September
673:8 September
552:neutrophils
548:macrophages
544:lymphocytes
536:eosinophils
441:anaphylaxis
317:136112-01-1
302:Identifiers
115:MedlinePlus
87:Trade names
2726:Categories
2599:Litigation
2586:Chris Gent
2535:Urs Rohner
2443:Parodontax
2251:Engerix-B
2064:Block Drug
1793:Omalizumab
1788:Fenspiride
1724:Ramatroban
1683:Pranlukast
1662:inhibition
1660:Eicosanoid
1605:Acefylline
1587:Nedocromil
1511:Mometasone
1491:Budesonide
1434:Etafedrine
1395:Vilanterol
1390:Olodaterol
1380:Carmoterol
1375:Abediterol
1353:Salmefamol
1348:Salmeterol
1339:Formoterol
1329:Bambuterol
1283:Reproterol
1278:Procaterol
1273:Pirbuterol
1268:Isoetarine
1258:Carbuterol
1253:Bitolterol
1205:Drugs for
1041:1 February
1008:1 February
823:30 January
615:References
564:cyclic AMP
532:mast cells
524:salmeterol
422:salmeterol
353:ChemSpider
308:CAS Number
192:Inhalation
70:Salmeterol
2669:Study 329
2480:Directors
2478:Board of
2453:Sensodyne
2433:Nicorette
2390:Emergen-C
2385:ChapStick
2365:BC Powder
2360:Aquafresh
2301:Pandemrix
2271:Hepatyrix
2169:Flixonase
2149:Augmentin
1930:Phase III
1918:Withdrawn
1783:Eprozinol
1773:Amlexanox
1748:Ibudilast
1597:Xanthines
1411:Ephedrine
1288:Rimiterol
1263:Fenoterol
1232:inhalants
1099:23 August
1070:23 August
878:30 August
853:30 August
785:Drugs.com
760:Drugs.com
540:basophils
480:indicated
185:Routes of
159:Pregnancy
101:Drugs.com
2716:Medicine
2688:Category
2438:NiQuitin
2428:Nicoderm
2423:Lucozade
2418:Horlicks
2400:Excedrin
2375:Caltrate
2321:Shingrix
2311:Rabavert
2306:Pediarix
2281:Infanrix
2261:FluLaval
2246:Cervarix
2241:Boostrix
2224:Vaccines
2199:Ventolin
2189:Serlipet
2179:Lamictal
2174:Hycamtin
2159:Beconase
2118:Products
1706:Zileuton
1367:agonists
1321:agonists
1245:agonists
974:23859431
939:16754916
873:ClinCalc
847:Archived
843:ClinCalc
698:DailyMed
667:DailyMed
560:catalyst
445:seizures
396:(verify)
199:ATC code
174: B3
161:category
143:DailyMed
2408:Geritol
2404:Flonase
2380:Centrum
2370:Biotene
2352:Actifed
2326:Twinrix
2316:Rotarix
2276:Hiberix
2256:Fluarix
2236:Bexsero
2194:Tagamet
2154:Avandia
2125:Current
1992:Current
1149:3 March
1124:3 March
790:3 March
765:4 March
638:1 April
464:generic
362:7987322
342:9811567
328:PubChem
254::
215:)
209: (
207:R03AK06
145::
121:a699063
2702:Portal
2471:People
2448:Ribena
2345:Former
2296:Menveo
2291:Kinrix
2266:Havrix
2231:Arexvy
2209:Zantac
2164:Boniva
2139:Advair
2132:Pharma
2034:Haleon
2029:Former
2014:Tesaro
1913:WHO-EM
1211:asthma
972:
937:
731:
550:, and
468:
437:thrush
426:asthma
410:Advair
382:D08699
281:â„ž-only
279:
266:
256:â„ž-only
242:
141:
2645:Other
2549:Other
2356:Advil
2074:Glaxo
2021:(85%)
1404:Other
1093:(EMA)
1064:(EMA)
1031:(EMA)
998:(EMA)
817:(FDA)
813:U.S.
597:Mylan
2458:Tums
2331:more
2214:more
2144:Alli
1215:COPD
1151:2023
1126:2023
1101:2021
1072:2021
1043:2021
1010:2021
970:PMID
935:PMID
880:2024
855:2024
825:2019
792:2019
767:2019
729:ISBN
706:2024
675:2024
640:2023
428:and
373:KEGG
97:AHFS
2395:Eno
1978:GSK
1219:R03
962:doi
925:doi
921:144
332:CID
268:POM
212:WHO
2728::
2328:…
2211:…
1926::
1421:,
1417:,
1230:,
1209::
1142:.
1117:.
1088:.
1059:.
1026:.
993:.
982:^
968:.
956:.
933:.
919:.
915:.
871:.
845:.
841:.
811:.
800:^
783:.
758:.
743:^
714:^
696:.
683:^
665:.
648:^
631:.
546:,
542:,
538:,
534:,
459:.
443:,
287:EU
275:US
262:UK
251:CA
244:S4
238:AU
170:AU
138:US
2704::
1970:e
1963:t
1956:v
1528:/
1425:)
1413:(
1365:2
1341:/
1319:2
1295:/
1243:2
1221:)
1217:(
1213:/
1198:e
1191:t
1184:v
1153:.
1128:.
1103:.
1074:.
1045:.
1012:.
976:.
964::
958:8
941:.
927::
882:.
857:.
827:.
794:.
769:.
737:.
708:.
677:.
642:.
289::
277::
264::
240::
172::
99:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
