17:
220:
G. C. Mangalindan, M. T. Talaue, L. J. Cruz, S. G. Franzblau, L. B. Adams, A. D. Richardson, C. M. Ireland and G. P. Conception, Planta Med., 2000, 66, 364
47:. At the present time a total of eleven 9-methyladeninium salts, agelasine A–I, epiagelasine C and agelin B, are known. All compounds carry a di
236:
184:
E. Piers and J. Y. Roberge, Tetrahedron Lett., 1992, 33, 6923; (b) H. Iio, K. Asao and T. Tokoroyama, J. Chem. Soc., Chem. Commun., 1985, 774
241:
65:
Chemists have reproduced (−)-agelasine A, (−)-agelasine B, (−)-agelasine E, (−)-agelasine F, and (+)-agelasine D by
93:
139:
H. Wu, H. Nakamura, J. Kobayashi, M. Kobayashi, Y. Ohizumi and Y. Hirata, Bull. Chem. Soc. Jpn., 1986, 59, 2495
175:
E. Piers, M. L. Livain, Y. Han, G. L. Plourde, L. Guy and W.-L. Yeh, J. Chem. Soc., Perkin Trans. 1, 1995, 963
193:
A. K. Bakkestuen, L.-L. Gundersen, D. Petersen, B. Utenova and A. Vik, Org. Biomol. Chem., 2005, 3, 1025
40:
148:
K. Ishida, M. Ishibashi, H. Shigemori, T. Sasaki and J. Kobayashi, Chem. Pharm. Bull., 1992, 40, 766
66:
246:
28:
81:
230:
73:
44:
166:
X. Fu, F. J. Schmitz, R. S. Tanner and M. Kelly-Borges, J. Nat. Prod., 1998, 61, 548
43:. Their contribution to the sponge is assumed to be some sort of protection against
59:
121:
H. Wu, H. Nakamura, J. Kobayashi and Y. Ohizumi, Tetrahedron Lett., 1984, 25, 3719
112:
H. Nakamura, H. Wu, Y. Ohizumi and Y. Hirata, Tetrahedron Lett., 1984, 25, 2989
51:
32:
85:
77:
48:
89:
16:
55:
58:
7-position. The agelasines are closely related in structure with the
211:
B. T. Utenova and L.-L. Gundersen, Tetrahedron Lett., 2004, 45, 4233
202:
K. Asao, H. Iio and T. Tokoroyama, Tetrahedron Lett., 1989, 30, 6401
157:
T. Hattori, K. Adachi and Y. Shizuri, J. Nat. Prod., 1997, 60, 411
130:
R. J. Capon and D. J. Faulkner, J. Am. Chem. Soc., 1984, 106, 1819
15:
72:
Agelasines are associated with bioactivities such as
80:effects, as well as contractive responses of
8:
105:
7:
14:
20:Chemical structure of agelasine A
84:and inhibition of Na/K-ATPase (
1:
237:Quaternary ammonium compounds
96:is reported for agelasine F.
263:
94:Mycobacterium tuberculosis
39:sp.). They are considered
27:are 7,9-dialkylpurinium
21:
41:secondary metabolites
31:isolated from marine
19:
242:Diterpene alkaloids
22:
92:activity against
67:organic synthesis
254:
221:
218:
212:
209:
203:
200:
194:
191:
185:
182:
176:
173:
167:
164:
158:
155:
149:
146:
140:
137:
131:
128:
122:
119:
113:
110:
88:). Furthermore,
262:
261:
257:
256:
255:
253:
252:
251:
227:
226:
225:
224:
219:
215:
210:
206:
201:
197:
192:
188:
183:
179:
174:
170:
165:
161:
156:
152:
147:
143:
138:
134:
129:
125:
120:
116:
111:
107:
102:
12:
11:
5:
260:
258:
250:
249:
244:
239:
229:
228:
223:
222:
213:
204:
195:
186:
177:
168:
159:
150:
141:
132:
123:
114:
104:
103:
101:
98:
82:smooth muscles
45:microorganisms
13:
10:
9:
6:
4:
3:
2:
259:
248:
245:
243:
240:
238:
235:
234:
232:
217:
214:
208:
205:
199:
196:
190:
187:
181:
178:
172:
169:
163:
160:
154:
151:
145:
142:
136:
133:
127:
124:
118:
115:
109:
106:
99:
97:
95:
91:
87:
83:
79:
75:
74:antimicrobial
70:
68:
63:
61:
57:
53:
50:
46:
42:
38:
34:
30:
26:
18:
216:
207:
198:
189:
180:
171:
162:
153:
144:
135:
126:
117:
108:
71:
64:
60:agelasimines
36:
24:
23:
231:Categories
100:References
52:side chain
25:Agelasines
86:NaKATPase
78:cytotoxic
49:terpenoid
90:in vitro
247:Purines
56:adenine
54:in the
33:sponges
37:Agelas
29:salts
76:and
69:.
233::
62:.
35:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
