245:. Once in the host genome, these introns went through a degeneration sequence, but promptly proliferated in large amounts after this degeneration. This allowed for the creation of an intron rich environment. Lambowitz and colleagues were able to determine that group 2 introns specifically were a longer form of intron, especially in ancestral form. This is specific to group 2 introns and is thought to be a result of their self-splicing mechanisms. Lambowitz furthered his research into group 2 introns, specifically exploring how these introns could help tell the story of ancestral bacterial lines using
169:. A majority of his work here centered around mitochondrial plasmid DNA found within fungal strains. Upon returning to St. Louis, Lambowitz promptly began studying splicing mechanisms of ribosomal RNA processing systems. Although he's not responsible for the discovery of splicing, the research that follows this within the bacterial community can largely be attributed to him, especially when regarding groups 2 introns. Lambowitz made the move to
249:. Along with colleagues, Lambowitz discovered that group 2 introns use a specific intron encoded protein in order to self-splice out of RNA. After understanding that these proteins serve to splice introns out of RNA, Lambowitz also discovered that the protein is capable of reverse transcriptase type functions in order to insert introns into host DNA. This discovery was crucial in understanding how these introns carried through
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After laying the foundation for group 2 introns and the functions they provide, Lambowitz has branched off into using these mechanisms in order to discover ancestral lineage of bacteria, as well as to pursue research surrounding RNA Diagnostic approaches to disease identification. These aspects are
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are a specific type of intron that is able to self-spice out of RNA segments and also are able to facilitate splicing and insertion into DNA in order to be replicated and passed on through ancestral pathways. These particular introns are especially important in understanding a variety of concepts
240:
Lambowitz focuses on a variety of these concepts while in the lab, such as Group ll Intron reverse transcriptase mechanisms or RNA sequencing. One of the first concepts surrounding group 2 introns that
Lambowitz began studying was their size and proliferation within cells. Group 2 introns
153:. After a stint at Rockefeller University, Lambowitz pursued a fellowship at the National Institute of Mental Health, followed by an acceptance of a faculty position at St Louis University School of Medicine under the department of biochemistry. Here he took part in work surrounding
253:. Also, an important connection to know was the relationship between intron encoded proteins and the size of group 2 introns seen in host cells. When these introns are capable of encoding for their own intron encoded proteins the introns tend to be much longer.
241:
specifically are often found in bacterial genomes, as well as in chloroplasts and mitochondrial genomes of eukaryotes. It was hypothesized that group 2 introns originated from proteobacteria that were incorporated into host genomes through the process of
173:
in 1997 becoming the director of The
Institute for Cellular and Molecular Biology there. Here he has cultivated a group of professionals that work on molecular biological research and received multiple merit awards in the process.
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951:
González-Delgado, Alejandro (2020-05-22). "Spacer acquisition from RNA mediated by a natural reverse transcriptase-Cas1 fusion protein associated with a type III-D CRISPR-Cas system in Vibrio vulnificus YJ016".
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220:, or common bread mold. Through utilizing this bacteria as a research specimen, Lambowitz has helped pioneer many new theories as well as discount some older, incorrect theories.
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where he continued his love for science in the laboratory. He received a Ph.D. from Yale and then decided to move his work to the
Johnson Research Foundation at the
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strains and examining the mitochondrial DNA that exists within them. In 1986 Lambowitz took a position with the Ohio
Eminent Scholar and Professor of
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is still unknown to the scientific community today. This is precisely why
Lambowitz focuses a majority of his research surrounding group 2 introns.
1141:
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Yao, Jun; Wu, Douglas C; Nottingham, Ryan M; Lambowitz, Alan M (2020-09-02). Nilsen, Timothy W; Manley, James L; Garcia-Blanco, Mariano A (eds.).
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869:"Template-switching mechanism of a group II intron-encoded reverse transcriptase and its implications for biological function and RNA-Seq"
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1042:"Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching"
30:
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347:"Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling"
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by Yale
University for his outstanding achievements in scholarship, teaching, academic administration, and public service.
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1009:"Decision letter: Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes"
142:
520:
660:; V. Derbyshire; M. Parker; B. Cousineau; A. Lambowitz (2002-01-01). "Mobile Introns: Pathways and Proteins".
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crucial in developing faster disease recognition techniques, therefore saving more lives in the long run.
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194:. In 2004, he was named a Fellow of the American Academy for Microbiology and named a Member of both the
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496:"Wilbur Cross Medal for Alumni Achievement | Yale Graduate School of Arts & Sciences"
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Lambowitz has spent a majority of his career focusing on a very common bacteria known as
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and discovered that the mechanism was incorrect. Lambowitz once again moved in 1973 to
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125:. Upon completing this degree in 1968, Lambowitz promptly began graduate school at
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Lentzsch, Alfred M.; Yao, Jun; Russell, Rick; Lambowitz, Alan M. (December 2019).
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Pfeffer, Suzanne R (2019-05-07). Pfeffer, Suzanne R; Settleman, Jeffrey (eds.).
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and has been instrumental in many bio-molecular processes and concepts, such as
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During his postdoctoral work, Lambowitz investigated a common mechanism of
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with honors from
Brooklyn College. In 1995 he was named a Fellow of the
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117:, a school specialized in science. Following high school, he attended
984:"Scientists find missing evolutionary link using tiny fungus crystal"
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Fellows of the
American Association for the Advancement of Science
812:"Extraction of tentative mobile introns in fungal histone genes"
190:. Following this in 2001 he was named a Fellow within the
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Members of the United States
National Academy of Sciences
755:"Origin of Spliceosomal Introns and Alternative Splicing"
257:
Viral and
Disease Utilization of Group ll Intron Splicing
664:. American Society of Microbiology. pp. 761–783.
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Academy of Medicine, Engineering and Science of Texas
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Fellows of the American Academy of Arts and Sciences
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American Association for the Advancement of Science
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37:
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1040:Wu, Douglas C.; Lambowitz, Alan M. (2017-08-21).
927:"Are heat-loving bacteria the key to biofuels?"
410:Proceedings of the National Academy of Sciences
810:Nishida, Hiromi; Yun, Choong-Soo (May 2011).
113:on December 24, 1947. Growing up he attended
8:
962:10.26226/morressier.5ebd45acffea6f735881b0f6
557:: CS1 maint: multiple names: authors list (
519:Lambowitz , Alan, Zimmerly, Steven (2004).
759:Cold Spring Harbor Perspectives in Biology
702:Cold Spring Harbor Perspectives in Biology
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202:. Most recently he was awarded with the
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954:25th Annual Meeting of the RNA Society
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237:within the microbiological community.
97:and mitochondrial ribosomal assembly.
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753:Irimia, M.; Roy, S. W. (2014-06-01).
188:American Academy of Arts and Sciences
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54:Brooklyn, New York, United States
121:for his undergraduate degree in
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873:Journal of Biological Chemistry
572:Saldanha, Roland; Mohr, Georg;
1142:Rockefeller University faculty
578:"Group I and group II introns"
406:"Profile of Alan M. Lambowitz"
1:
1147:Ohio State University faculty
1127:Stuyvesant High School alumni
576:; Lambowitz, Alan M. (1993).
404:Zagorski, Nick (2006-02-07).
89:in Molecular Biosciences and
87:University of Texas at Austin
472:"Lambowitz Wins MERIT Award"
196:National Academy of Sciences
771:10.1101/cshperspect.a016071
714:10.1101/cshperspect.a032375
547:– via Annual Reviews.
105:Alan Lambowitz was born in
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670:10.1128/9781555817954.ch31
595:10.1096/fasebj.7.1.8422962
476:Lambowitz Wins MERIT Award
131:University of Pennsylvania
525:Annual Review of Genetics
521:"Mobile Group ll Introns"
143:oxidative phosphorylation
28:
886:10.1074/jbc.ra119.011337
228:Much of the function of
224:Group ll Intron Research
1132:Brooklyn College alumni
1122:Academics from Brooklyn
1026:10.7554/elife.47544.030
816:Mobile Genetic Elements
431:10.1073/pnas.0508183103
85:is a professor for the
1137:Yale University alumni
147:Rockefeller University
115:Stuyvesant High School
828:10.4161/mge.1.1.15431
167:Ohio State University
323:sites.cns.utexas.edu
299:sites.cns.utexas.edu
182:Lambowitz graduated
1058:2017NatSR...7.8421W
879:(51): 19764–19784.
422:2006PNAS..103.1669Z
364:10.7554/eLife.60743
1046:Scientific Reports
204:Wilbur Cross Medal
159:Molecular Genetics
679:978-1-55581-209-6
638:www.nasonline.org
582:The FASEB Journal
251:ancestral lineage
217:Neurospora Crassa
178:Honors and awards
151:mitochondrial DNA
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357:: e60743.
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304:2021-04-13
266:References
155:Neurospora
44:1947-12-24
1074:2045-2322
970:240862843
895:0021-9258
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123:Chemistry
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107:Brooklyn
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