395:
the
Immunodot technology for IgE-based detection of allergies and other diseases such as HIV using low-cost cellulose strips and optical density measurements. He subsequently founded the Centre Medical des Grand-Places (CMG) company with a number of investors, including the Japanese pharmaceutical firm Nippon Zoki. One of Alain de Weck's main collaborators during this time was Dr. Michael Derer. CMG successfully developed, manufactured and sold a series of diagnostic allergy screening tests under the name "TOP SCREEN" to test for the presence of specific IgEs to a variety of about 40 of the most common allergens. In 1994-1995 CMG added diagnostic tests for dog allergy and was subsequently acquired by Heska of Fort Collins, Colorado, in 1997.
317:. From 1961 to 1971 he ran a successful clinical immunology and allergy program under Prof. Hans Kuske in the Department of Dermatology at the Inselspital Bern, the university hospital. During this time he investigated a growing variety of topics such as hapten-antibody interactions, contact dermatitis, immunological tolerance to simple chemicals, delayed (type IV)
394:
In his entrepreneurial activities Alain de Weck focused initially on the immunological aspects of aging and was co-founder of an unsuccessful clinic called CLIMARLY (1978-1982). His second more successful venture resulted from research on cellular assays for low cost in-vitro allergy testing using
325:
proliferation, among others. On
October 1, 1971, he became the founding chairman of the Institute of Clinical Immunology and Allergy at the University of Bern, a position he held until his retirement in 1993. One of the noteworthy contributions was the first description of the now well-known
385:
such as HIV. The
Institute offered a full curriculum in Immunology and Allergy at the University and also collaborated on textbooks of this rapidly evolving field. The Institute hosted a large number of foreign researchers and visitors starting in the 1970s.
160:
from 1971 to 1993 and authored or co-authored over 600 peer-reviewed publications. He is the recipient of a number of patents that led to commercial allergy products and services. He served as president of international scientific organizations such as the
601:"Method for the determination of sulfidoleukotrienes in tissues and biological fluids and its application in diagnosis of allergies and other inflammatory diseases.", United States Patent 5,487,977, issued January 30, 1996
337:
Prof. Alain de Weck was a specialist at translating immunological theory into new medical applications for both diagnosis and treatment. His main contributions range from the characterization of the molecular causes of
1099:
169:) and was founder and later CEO of the Centre MĂ©dical des Grand-Places (CMG) company, acquired by Heska of Fort Collins (Nasdaq: HSKA) in 1997. In later years he continued his research at the
910:
Sanz, M. L.; et al. (2002). "Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics".
1141:
412:
888:
WĂĽhtrich B.; Wydler B. (1999). "Zur spezifischen IgE-Diagnostik: Vergleich zweier In-Vitro
Streifentests (IgE-Quick und Immunodot) mit CAP-FEIA System und den Proktests".
777:
de Weck A.L.; Gutersohn G.; Buetikofer E. (1969). "La maladie des laveurs de fromage ("Kaesewascherkrankheit"), une forme particuliere du syndrome du poumon du fermier".
480:
for immunological testing, as well as a frequent columnist in newspapers voicing his opinion on a wide variety of topics such as the distinction between true science and
152:, (July 26, 1928 – April 8, 2013), was a Swiss immunologist and allergist. His main scientific contributions were in the area of characterization and prevention of
404:
253:. Starting in 1954, he came under the tutelage of Professor Werner Jadassohn, then the head of the Department of Dermatology in Geneva, the son of dermatologist,
162:
250:
31:
309:
Starting in 1961, after his return to
Switzerland, he established himself as an independent researcher and eventually full professor (Ordinarius) at the
1146:
1151:
431:. One of the highlights of these activities was his chairmanship of the XIIIth IAACI Congress in Montreux in 1988 with 5,600 participants
453:
403:
Alain de Weck was well known for was his leadership in and of international scientific organizations. He served as president of IUIS, the
104:
238:
290:
1015:
314:
1057:
945:
de Weck, A. (1984). "An
Explanation of the Mode of Action of Gynatren/SolcoTrichovac Based on Immunological Considerations".
485:
178:
1126:
1005:
Beda M. Stadler et al. (Eds.): From
Allergy to Immunology: Anniversary Symposium in Honour of Professor Alain de Weck.
297:. During this time, Alain de Weck made initial contributions to what later became one of his signature research areas:
1131:
354:(IgE) synthesis and associated receptors, and the development of new diagnostics techniques such as in-vitro cellular
589:"Strip for immunological analysis and method for its preparation." European Patent EP 0174247, issued June 5, 1991.
408:
166:
416:
643:"The Preparation and Some Properties of Penicillenic Acid Derivatives Relevant to Penicillin Hypersensitivity"
301:. In particular he developed penicilloyl-polylysine (PPL) as a test reagent for detecting penicillin allergy.
1075:
1136:
407:
from 1983-1986 as well as the
International Association of Allergology and Clinical Immunology (IAACI), now
206:
613:
Ruby
Pawankar, MD, PhD, FAAAAI, "A Tribute to Alain de Weck", World Allergy Organization, April 15, 2013,
369:
Clinical activities included services such as allergy diagnostics using allergen-specific IgE antibodies (
286:
469:
434:
Alain de Weck received several awards and recognitions for his scientific work including, among others:
363:
282:
170:
133:
690:
de Weck, A. L. (1964). "Penicillin
Allergy: Its Detection by an Improved Hæmagglutination Technique".
1121:
1116:
382:
214:
423:
was to bring new countries and scientists into these organizations, including those from the former
377:(mainly kidney and liver), as well as cellular immunology testing particularly for the diagnosis of
446:
411:(WAO) from 1985-1988. Other societies like the Collegium Internationale Allergologicum (CIA), the
100:
465:
339:
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274:
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nipple as a model for the human skin. This led to the first histopathological demonstration that
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157:
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30:
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165:(IUIS) and the International Association for Allergy and Clinical Immunology (IAACI) (now the
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254:
1028:
de Weck AL. Farewell Address: “40 Years of allegro-immunology: from the nipple unto milk",
242:
798:
Allergy to penicillin and related antibiotics: antigenic and immunochemical mechanisms".
173:
in Spain and wrote on a wide range of topics such as the distinction between science and
811:
862:
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in 1993 Alain de Weck remained active as an Extraordinary Professor at the pontifical
1110:
923:
853:
373:) and mediator analyses, leukocyte histocompatibility antigen (HLA group) typing for
194:
424:
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258:
246:
153:
1071:
Alain de Weck served as president of IAACI, the precursor of WAO, from 1985-1988.
753:
973:
Atlas of Immuno-Allergology: An Illustrated Primer for Health Care Professionals
489:
278:
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156:. He was the founding director of the Institute of Clinical Immunology at the
51:
1089:
HESKA is a firm specializing in veterinary diagnostic products and services.
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419:(WHO) also benefitted from his leadership. One of his accomplishments in
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996:, Universität Bern : ein Bericht, self published, Bern, Switzerland
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476:, Spain where he collaborated on further development and validation of
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355:
226:
202:
88:
drug allergy, in-vitro immunological testing, cheese washer's disease
257:. There he started investigating the occurrence and root causes of
1076:
Official Website of the current University Institute of Immunology
230:
1093:
542:
Oesterische Gesellschaft fuer Allergologie und Immunologie (Ă–GAI)
205:
and later completed his Baccalauréat in classical studies at the
1066:
137:
615:
http://www.worldallergy.org/UserFiles/Tribute_AlaindeWeck.pdf
641:
Parker, C. W.; de Weck, A.L.; Kern, M.; Eisen, H.N. (1962).
569:
Pichler W., Zum Gedenken an Alain L. de Weck (1928 – 2013),
1062:
Alain de Weck served as president of IUIS from 1983-1986.
366:
used in recurrent nonspecific gynaecological infections.
1048:
984:
25 Jahre Allergie und klinische Immunologie: 1967-1971,
330:(in German: "Kaesewascherkrankheit"), a special form of
1084:
545:
415:(EAACI), the Swiss Society, the German Society and the
1100:
Association française pour l'information scientifique
285:
funded foreign research fellow from Switzerland - at
986:
Abteilung fĂĽr Allergologie und klinische Immunologie
838:"Dust mite allergens and asthma—A worldwide problem"
975:. Hogrefe & Huber Publishing, 3rd Edition, 1995
413:
European Academy of Allergy and Clinical Immunology
241:. During this time he was an early resident at the
125:
117:
92:
84:
62:
37:
21:
1067:Official Website of the World Allergy Organization
399:International scientific organizations and awards
629:Heska Acquires CMG Centre Medical of Switzerland
362:tests. He elucidated the mechanism of action of
738:"Memories: Failures and Dreams · A Book Review"
631:, Press Release, PR Newswire, September 3, 1997
544:, Wissenschaftliche Veranstaltungen der Ă–GAI,
540:Notice of Award of Clemens von Pirquet Medal,
513:Blut Zeitschrift fĂĽr die Gesamte Blutforschung
405:International Union of Immunological Societies
342:, the suppression of allergic reactions using
293:from 1958 to 1960 under the guidance of Prof.
213:in 1947. He obtained his M.D. degree from the
163:International Union of Immunological Societies
779:Schweizerische Medizinische Wochenzeitschrift
8:
988:, Klinik fĂĽr Dermatologie : 1971-1992,
16:Swiss immunologist and allergist (1928–2013)
1098:published by the French organisation AFIS (
1142:Washington University in St. Louis fellows
905:
903:
883:
881:
842:Journal of Allergy and Clinical Immunology
715:
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624:
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251:Cité Internationale Universitaire de Paris
217:in November 1953 after medical studies in
18:
1049:Foundation of the de Weck family (French)
861:
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947:Gynäkologisch-geburtshilfliche Rundschau
720:Dinosaurier der Immunologie tritt zurĂĽck
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500:
346:, the international standardization of
836:Platts-Mills, T.; et al. (1989).
597:
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281:. He then stayed - as the first U.S.
7:
452:Election as a foreign member of the
1030:Clinical & Experimental Allergy
812:10.1146/annurev.pa.13.040173.001521
233:at various hospitals including the
990:Institut fĂĽr klinische Immunologie
742:World Allergy Organization Journal
291:Washington University in St. Louis
14:
912:Clinical and Experimental Allergy
315:Swiss National Science Foundation
924:10.1046/j.1365-2222.2002.01305.x
647:Journal of Experimental Medicine
29:
492:policy in different countries.
484:, the immunological aspects of
313:with initial support from the
1094:Website of pseudo-sciences.org
486:genetically modified organisms
464:After his retirement from the
454:Académie Nationale de Médecine
179:genetically modified organisms
105:Académie Nationale de Médecine
1:
800:Annual Review of Pharmacology
854:10.1016/0091-6749(89)90128-0
754:10.1097/WOX.0b013e3181a5d3a1
121:Clinical Immunology, Allergy
1152:University of Geneva alumni
1147:Collège Saint-Michel alumni
1168:
558:World Who’s Who in Science
409:World Allergy Organization
245:designed by the architect
239:Pitié-Salpêtrière Hospital
229:. He did his residency in
167:World Allergy Organization
488:(GMOs) and the future of
417:World Health Organization
193:Alain de Weck grew up in
143:
110:
28:
1058:Official website of IUIS
1019:(Symposium Proceedings).
971:Centner, Jacques et al.
305:Scientific contributions
328:Cheese Washer's Disease
181:(GMOs) and comparative
796:Stewart G.T. (1973). "
364:lactobacillus vaccines
23:Alain Ladislas de Weck
1080:in Bern, Switzerland.
722:, Newspaper Article,
659:10.1084/jem.115.4.803
470:University of Navarra
283:Public Health Service
277:is due to sensitized
171:University of Navarra
134:University of Navarra
103:Medal (1990), Member
726:, September 10, 1993
577:, Nr. 5/2013, S. 1–2
546:http://www.oegai.org
519:(6): 407–408. 1973.
383:autoimmune disorders
215:University of Geneva
207:Collège Saint-Michel
1127:Swiss immunologists
447:Clemens von Pirquet
177:, the emergence of
101:Clemens von Pirquet
1132:People from Valais
525:10.1007/BF01632756
466:University of Bern
340:penicillin allergy
311:University of Bern
299:penicillin allergy
275:contact dermatitis
263:contact dermatitis
158:University of Bern
130:University of Bern
959:10.1159/000269922
736:Ring, J. (2009).
698:(4936): 975–977.
440:Robert Koch Prize
421:science diplomacy
344:hapten inhibition
147:
146:
112:Scientific career
97:Robert Koch Prize
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442:in Life Sciences
390:Entrepreneurship
375:organ transplant
352:Immunoglobulin E
350:to the study of
319:hypersensitivity
255:Joseph Jadassohn
150:Alain L. de Weck
69:
47:
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560:. 1968, p. 454.
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243:Pavillon Suisse
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1043:External links
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295:Herman Eisen
259:inflammation
247:Le Corbusier
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154:drug allergy
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126:Institutions
111:
68:(2013-04-08)
1122:2013 deaths
1117:1928 births
994:Inselspital
806:: 309–324.
573:, Jahrgang
490:health care
358:as well as
279:lymphocytes
267:lymphocytes
261:as well as
183:health care
78:Switzerland
1111:Categories
1007:Hans Huber
896:: 215–222.
496:References
460:Retirement
334:syndrome.
323:lymphocyte
271:guinea pig
269:using the
237:, and the
52:Les Avants
44:1928-07-26
748:(5): 62.
381:and some
371:RAST test
348:allergens
189:Education
932:11929494
724:Der Bund
677:14483914
474:Pamplona
223:Lausanne
219:Fribourg
211:Fribourg
185:policy.
99:(1972),
74:Fribourg
56:Montreux
872:2645343
863:2491145
820:4581913
763:3651007
668:2137523
265:due to
249:at the
54:, near
1036:490-6.
1014:
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860:
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692:Nature
675:
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429:Taiwan
356:assays
227:Geneva
203:Geneva
118:Fields
93:Awards
1085:HESKA
449:Medal
445:1990
438:1972
231:Paris
1034:(5):
1012:ISBN
928:PMID
868:PMID
816:PMID
673:PMID
427:and
321:and
225:and
63:Died
38:Born
1096:—
1087:—
1060:—
955:doi
920:doi
858:PMC
850:doi
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758:PMC
750:doi
700:doi
696:202
663:PMC
655:doi
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521:doi
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289:at
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